Investigación

2023

• 
  1.

  Richardson-Parry A, Baas C, Donde S, Ferraiolo B, Karmo M, Maravic Z, Münter L, Ricci-Cabello I, Silva M, Tinianov S, Valderas JM, Woodruff S, van Vugt J. Interventions to reduce cancer screening inequities: the perspective and role of patients, advocacy groups, and empowerment organizations. Int J Equity Health. 2023;22(1):19.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Health inequities lead to low rates of cancer screening in certain populations, such as low-income and ethnic minority groups. Different interventions to address this have been developed with mixed results. However, interventions are not always developed in collaboration with the people they target. The aim of our article is to present the viewpoint of patients, survivors, advocates, and lay persons on interventions to increase cancer screening from a health inequity perspective. METHODS: We prepared talking points to guide discussions between coauthors, who included representatives from nine patient and survivor advocacy groups, organizations working for citizen/patient empowerment, and health equity experts. Perspectives and opinions were first collected through video conferencing meetings and a first draft of the paper was prepared. All authors, read through, revised, and discussed the contents to reach an agreement on the final perspectives to be presented. RESULTS: Several themes were identified: it is important to not view screening as a discrete event; barriers underlying an individual's access and willingness to undergo screening span across a continuum; individually tailored interventions are likely to be more effective than a one-size fits-all approach because they may better accommodate the person's personal beliefs, knowledge, behaviors, and preferences; targeting people who are unknown to medical services and largely unreachable is a major challenge; including professional patient advocacy groups and relevant lay persons in the cocreation of interventions at all stages of design, implementation, and evaluation is essential along with relevant stakeholders (healthcare professionals, researchers, local government and community organizations etc). CONCLUSIONS: Interventions to address cancer screening inequity currently do not adequately solve the issue, especially from the viewpoint of patients, survivors, and lay persons. Several core pathways should be focused on when designing and implementing interventions: advancing individually tailored interventions; digital tools and social media; peer-based approaches; empowerment; addressing policy and system barriers; better design of interventions; and collaboration, including the involvement of patients and patient advocacy organizations.

  @article{RN129,
  abstract = {BACKGROUND: Health inequities lead to low rates of cancer screening in certain populations, such as low-income and ethnic minority groups. Different interventions to address this have been developed with mixed results. However, interventions are not always developed in collaboration with the people they target. The aim of our article is to present the viewpoint of patients, survivors, advocates, and lay persons on interventions to increase cancer screening from a health inequity perspective. METHODS: We prepared talking points to guide discussions between coauthors, who included representatives from nine patient and survivor advocacy groups, organizations working for citizen/patient empowerment, and health equity experts. Perspectives and opinions were first collected through video conferencing meetings and a first draft of the paper was prepared. All authors, read through, revised, and discussed the contents to reach an agreement on the final perspectives to be presented. RESULTS: Several themes were identified: it is important to not view screening as a discrete event; barriers underlying an individual's access and willingness to undergo screening span across a continuum; individually tailored interventions are likely to be more effective than a one-size fits-all approach because they may better accommodate the person's personal beliefs, knowledge, behaviors, and preferences; targeting people who are unknown to medical services and largely unreachable is a major challenge; including professional patient advocacy groups and relevant lay persons in the cocreation of interventions at all stages of design, implementation, and evaluation is essential along with relevant stakeholders (healthcare professionals, researchers, local government and community organizations etc). CONCLUSIONS: Interventions to address cancer screening inequity currently do not adequately solve the issue, especially from the viewpoint of patients, survivors, and lay persons. Several core pathways should be focused on when designing and implementing interventions: advancing individually tailored interventions; digital tools and social media; peer-based approaches; empowerment; addressing policy and system barriers; better design of interventions; and collaboration, including the involvement of patients and patient advocacy organizations.},
  author = {Richardson-Parry, A. and Baas, C. and Donde, S. and Ferraiolo, B. and Karmo, M. and Maravic, Z. and Münter, L. and Ricci-Cabello, I. and Silva, M. and Tinianov, S. and Valderas, J. M. and Woodruff, S. and van Vugt, J.},
  journal = {Int J Equity Health},
  keywords = {grapp-caib},
  number = 1,
  pages = 19,
  title = {Interventions to reduce cancer screening inequities: the perspective and role of patients, advocacy groups, and empowerment organizations},
  type = {Journal Article},
  volume = 22,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN129
  %A Richardson-Parry, A.
  %A Baas, C.
  %A Donde, S.
  %A Ferraiolo, B.
  %A Karmo, M.
  %A Maravic, Z.
  %A Münter, L.
  %A Ricci-Cabello, I.
  %A Silva, M.
  %A Tinianov, S.
  %A Valderas, J. M.
  %A Woodruff, S.
  %A van Vugt, J.
  %D 2023
  %J Int J Equity Health
  %N 1
  %P 19
  %R 10.1186/s12939-023-01841-6
  %T Interventions to reduce cancer screening inequities: the perspective and role of patients, advocacy groups, and empowerment organizations
  %V 22
  %X BACKGROUND: Health inequities lead to low rates of cancer screening in certain populations, such as low-income and ethnic minority groups. Different interventions to address this have been developed with mixed results. However, interventions are not always developed in collaboration with the people they target. The aim of our article is to present the viewpoint of patients, survivors, advocates, and lay persons on interventions to increase cancer screening from a health inequity perspective. METHODS: We prepared talking points to guide discussions between coauthors, who included representatives from nine patient and survivor advocacy groups, organizations working for citizen/patient empowerment, and health equity experts. Perspectives and opinions were first collected through video conferencing meetings and a first draft of the paper was prepared. All authors, read through, revised, and discussed the contents to reach an agreement on the final perspectives to be presented. RESULTS: Several themes were identified: it is important to not view screening as a discrete event; barriers underlying an individual's access and willingness to undergo screening span across a continuum; individually tailored interventions are likely to be more effective than a one-size fits-all approach because they may better accommodate the person's personal beliefs, knowledge, behaviors, and preferences; targeting people who are unknown to medical services and largely unreachable is a major challenge; including professional patient advocacy groups and relevant lay persons in the cocreation of interventions at all stages of design, implementation, and evaluation is essential along with relevant stakeholders (healthcare professionals, researchers, local government and community organizations etc). CONCLUSIONS: Interventions to address cancer screening inequity currently do not adequately solve the issue, especially from the viewpoint of patients, survivors, and lay persons. Several core pathways should be focused on when designing and implementing interventions: advancing individually tailored interventions; digital tools and social media; peer-based approaches; empowerment; addressing policy and system barriers; better design of interventions; and collaboration, including the involvement of patients and patient advocacy organizations.
  

• 
  1.

  Ramírez-Manent JI, Jover AM, Martinez CS, Tomás-Gil P, Martí-Lliteras P, López-González Á A. Waist Circumference Is an Essential Factor in Predicting Insulin Resistance and Early Detection of Metabolic Syndrome in Adults. Nutrients. 2023;15(2).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Metabolic syndrome (Met-S) is considered one of the most important health problems of the 21st century. It includes a group of metabolic disorders that increase the risk of cardiovascular diseases such as overweight and obesity, elevated lipid profile and blood pressure and insulin resistance (IR). Based on the information mentioned above in which there seems to be a relationship between IR and Met-S, the objective of this work was twofold: on the one hand, to assess the relationship between the values of different insulin resistance risk scales and Met-S determined with three different scales, and on the other, to determine whether any of the components of Met-S predispose more to the appearance of IR. METHODS: A descriptive cross-sectional study of 418,343 workers. Waist circumference was measured and evaluated together with six formulas to assess the insulin resistance index. Categorical variables were evaluated by calculating the frequency and distribution of each one. For quantitative variables, mean and standard deviation were determined, and Student's t-test was applied, while for qualitative variables, the chi-square test was performed. The usefulness of the different risk scales for insulin resistance for predicting metabolic syndrome was evaluated using ROC curves, the area under the curve (AUC), as well as their cut-off points for sensitivity, specificity, and the Youden index. RESULTS: People with metabolic syndrome applying any criteria had higher values in the IR risk scales. The different IR scales made it possible to adequately classify people with metabolic syndrome. Of the three definitions of Met-S, the one that showed the greatest relationship with IR was IDF. CONCLUSIONS: Most risk scales for insulin resistance enable the presence of metabolic syndrome to be adequately classified, finding the best ones if the International Diabetes Federation (IDF) criteria are applied. Of the elements included in the Met-S, the one that seems to increase the risk of presenting IR the most is waist circumference; hence, the Met-S definition that is most related to IR is that of the IDF, which is the only one of the three in which a high value of waist circumference is necessary to be able to diagnose Met-S. Waist circumference can be considered the central essential component for detecting insulin resistance and, therefore, the early detection of metabolic syndrome.

  @article{RN126,
  abstract = {BACKGROUND: Metabolic syndrome (Met-S) is considered one of the most important health problems of the 21st century. It includes a group of metabolic disorders that increase the risk of cardiovascular diseases such as overweight and obesity, elevated lipid profile and blood pressure and insulin resistance (IR). Based on the information mentioned above in which there seems to be a relationship between IR and Met-S, the objective of this work was twofold: on the one hand, to assess the relationship between the values of different insulin resistance risk scales and Met-S determined with three different scales, and on the other, to determine whether any of the components of Met-S predispose more to the appearance of IR. METHODS: A descriptive cross-sectional study of 418,343 workers. Waist circumference was measured and evaluated together with six formulas to assess the insulin resistance index. Categorical variables were evaluated by calculating the frequency and distribution of each one. For quantitative variables, mean and standard deviation were determined, and Student's t-test was applied, while for qualitative variables, the chi-square test was performed. The usefulness of the different risk scales for insulin resistance for predicting metabolic syndrome was evaluated using ROC curves, the area under the curve (AUC), as well as their cut-off points for sensitivity, specificity, and the Youden index. RESULTS: People with metabolic syndrome applying any criteria had higher values in the IR risk scales. The different IR scales made it possible to adequately classify people with metabolic syndrome. Of the three definitions of Met-S, the one that showed the greatest relationship with IR was IDF. CONCLUSIONS: Most risk scales for insulin resistance enable the presence of metabolic syndrome to be adequately classified, finding the best ones if the International Diabetes Federation (IDF) criteria are applied. Of the elements included in the Met-S, the one that seems to increase the risk of presenting IR the most is waist circumference; hence, the Met-S definition that is most related to IR is that of the IDF, which is the only one of the three in which a high value of waist circumference is necessary to be able to diagnose Met-S. Waist circumference can be considered the central essential component for detecting insulin resistance and, therefore, the early detection of metabolic syndrome.},
  author = {Ramírez-Manent, J. I. and Jover, A. M. and Martinez, C. S. and Tomás-Gil, P. and Martí-Lliteras, P. and López-González Á, A.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  number = 2,
  title = {Waist Circumference Is an Essential Factor in Predicting Insulin Resistance and Early Detection of Metabolic Syndrome in Adults},
  type = {Journal Article},
  volume = 15,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN126
  %A Ramírez-Manent, J. I.
  %A Jover, A. M.
  %A Martinez, C. S.
  %A Tomás-Gil, P.
  %A Martí-Lliteras, P.
  %A López-González Á, A.
  %D 2023
  %J Nutrients
  %N 2
  %R 10.3390/nu15020257
  %T Waist Circumference Is an Essential Factor in Predicting Insulin Resistance and Early Detection of Metabolic Syndrome in Adults
  %V 15
  %X BACKGROUND: Metabolic syndrome (Met-S) is considered one of the most important health problems of the 21st century. It includes a group of metabolic disorders that increase the risk of cardiovascular diseases such as overweight and obesity, elevated lipid profile and blood pressure and insulin resistance (IR). Based on the information mentioned above in which there seems to be a relationship between IR and Met-S, the objective of this work was twofold: on the one hand, to assess the relationship between the values of different insulin resistance risk scales and Met-S determined with three different scales, and on the other, to determine whether any of the components of Met-S predispose more to the appearance of IR. METHODS: A descriptive cross-sectional study of 418,343 workers. Waist circumference was measured and evaluated together with six formulas to assess the insulin resistance index. Categorical variables were evaluated by calculating the frequency and distribution of each one. For quantitative variables, mean and standard deviation were determined, and Student's t-test was applied, while for qualitative variables, the chi-square test was performed. The usefulness of the different risk scales for insulin resistance for predicting metabolic syndrome was evaluated using ROC curves, the area under the curve (AUC), as well as their cut-off points for sensitivity, specificity, and the Youden index. RESULTS: People with metabolic syndrome applying any criteria had higher values in the IR risk scales. The different IR scales made it possible to adequately classify people with metabolic syndrome. Of the three definitions of Met-S, the one that showed the greatest relationship with IR was IDF. CONCLUSIONS: Most risk scales for insulin resistance enable the presence of metabolic syndrome to be adequately classified, finding the best ones if the International Diabetes Federation (IDF) criteria are applied. Of the elements included in the Met-S, the one that seems to increase the risk of presenting IR the most is waist circumference; hence, the Met-S definition that is most related to IR is that of the IDF, which is the only one of the three in which a high value of waist circumference is necessary to be able to diagnose Met-S. Waist circumference can be considered the central essential component for detecting insulin resistance and, therefore, the early detection of metabolic syndrome.
  

2022

• 
  1.

  Gómez-Sánchez L, Rodr’iguez-Sánchez E, Ramos R, Marti-Lluch R, Gómez-Sánchez M, Lugones-Sánchez C, Tamayo-Morales O, Llamas-Ramos I, Rigo F, Garc’ia-Ortiz L, Gómez-Marcos MA. The Association of Dietary Intake with Arterial Stiffness and Vascular Ageing in a Population with Intermediate Cardiovascular RisktextemdashA MARK Study. Nutrients [Internet]. MDPI AG; 2022 Jan.;14(2):244. https://doi.org/10.3390%2Fnu14020244

  URLBibTeXEndNoteDOIBibSonomyDownload

  @article{G_mez_S_nchez_2022,
  author = {Gómez-Sánchez, Leticia and Rodr'iguez-Sánchez, Emiliano and Ramos, Rafel and Marti-Lluch, Ruth and Gómez-Sánchez, Marta and Lugones-Sánchez, Cristina and Tamayo-Morales, Olaya and Llamas-Ramos, Ines and Rigo, Fernando and Garc'ia-Ortiz, Luis and Gómez-Marcos, Manuel A.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {jan},
  number = 2,
  pages = 244,
  publisher = {MDPI AG},
  title = {The Association of Dietary Intake with Arterial Stiffness and Vascular Ageing in a Population with Intermediate Cardiovascular RisktextemdashA MARK Study},
  volume = 14,
  year = 2022
  }
  

  %0 Journal Article
  %1 G_mez_S_nchez_2022
  %A Gómez-Sánchez, Leticia
  %A Rodr'iguez-Sánchez, Emiliano
  %A Ramos, Rafel
  %A Marti-Lluch, Ruth
  %A Gómez-Sánchez, Marta
  %A Lugones-Sánchez, Cristina
  %A Tamayo-Morales, Olaya
  %A Llamas-Ramos, Ines
  %A Rigo, Fernando
  %A Garc'ia-Ortiz, Luis
  %A Gómez-Marcos, Manuel A.
  %D 2022
  %I MDPI AG
  %J Nutrients
  %N 2
  %P 244
  %R 10.3390/nu14020244
  %T The Association of Dietary Intake with Arterial Stiffness and Vascular Ageing in a Population with Intermediate Cardiovascular RisktextemdashA MARK Study
  %U https://doi.org/10.3390%2Fnu14020244
  %V 14
  

• 
  1.

  Zamanillo-Campos R, Chaplin A, Romaguera D, Abete I, Salas-Salvadó J, Martín V, Estruch R, Vidal J, Ruiz-Canela M, Babio N, Fiol F, de Paz JA, Casas R, Olbeyra R, Martínez-González MA, García-Gavilán JF, Goday A, Fernandez-Lazaro CI, Martínez JA, Hu FB, Konieczna J. Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators. Clin Nutr. 2022;41(10):2264-7.

  AbstractBibTeXEndNoteDOIBibSonomy

  BACKGROUND & AIMS: The quality of dietary carbohydrates rather than total carbohydrate intake may determine the accumulation of visceral fat; however, to date, few studies have examined the impact of diet on adiposity using specific imaging techniques. Thus, the aim of this prospective study was to investigate the association between concurrent changes in carbohydrate quality index (CQI) and objectively-quantified adiposity distribution over a year. METHODS: We analyzed a cohort of 1476 participants aged 55-75 years with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus randomized controlled trial. Dietary intake information was obtained at baseline, 6- and 12-months from a validated 143-item semi-quantitative food-frequency questionnaire, and CQI (range: 4 to 20) was calculated based on four dietary criteria: total dietary fibre, glycemic index, wholegrain/total grain carbohydrate ratio, and solid/total carbohydrate ratio. Overall and regional adiposity (total body fat, visceral fat and android-to-gynoid fat ratio) was quantified using dual-energy X-ray absorptiometry at all three time points. Multiple adjusted linear mixed-effects models were used to assess associations between concurrent changes in repeatedly measured CQI and adiposity over time. RESULTS: After controlling for potential confounding factors, a 3-point increment in CQI over 12-month follow-up was associated with a decrease in visceral fat (β -0.067 z-score, 95% CI -0.088; -0.046, p < 0.001), android-to-gynoid fat ratio (-0.038, -0.059; -0.017, p < 0.001), and total fat (-0.064, -0.080; -0.047, p < 0.001). Fibre intake and the ratio of wholegrain/total grain showed the strongest inverse associations with all adiposity indicators. CONCLUSIONS: In this prospective cohort of older adults with overweight/obesity and MetS, we found that improvements in dietary carbohydrate quality over a year were associated with concurrent favorable changes in visceral and overall fat deposition. These associations were mostly driven by dietary fibre and the wholegrain/total grain ratio. TRIAL REGISTRATION: The trial was registered at the International Standard Randomized. CONTROLLED TRIAL: (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

  @article{RN110,
  abstract = {BACKGROUND & AIMS: The quality of dietary carbohydrates rather than total carbohydrate intake may determine the accumulation of visceral fat; however, to date, few studies have examined the impact of diet on adiposity using specific imaging techniques. Thus, the aim of this prospective study was to investigate the association between concurrent changes in carbohydrate quality index (CQI) and objectively-quantified adiposity distribution over a year. METHODS: We analyzed a cohort of 1476 participants aged 55-75 years with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus randomized controlled trial. Dietary intake information was obtained at baseline, 6- and 12-months from a validated 143-item semi-quantitative food-frequency questionnaire, and CQI (range: 4 to 20) was calculated based on four dietary criteria: total dietary fibre, glycemic index, wholegrain/total grain carbohydrate ratio, and solid/total carbohydrate ratio. Overall and regional adiposity (total body fat, visceral fat and android-to-gynoid fat ratio) was quantified using dual-energy X-ray absorptiometry at all three time points. Multiple adjusted linear mixed-effects models were used to assess associations between concurrent changes in repeatedly measured CQI and adiposity over time. RESULTS: After controlling for potential confounding factors, a 3-point increment in CQI over 12-month follow-up was associated with a decrease in visceral fat (β -0.067 z-score, 95% CI -0.088; -0.046, p < 0.001), android-to-gynoid fat ratio (-0.038, -0.059; -0.017, p < 0.001), and total fat (-0.064, -0.080; -0.047, p < 0.001). Fibre intake and the ratio of wholegrain/total grain showed the strongest inverse associations with all adiposity indicators. CONCLUSIONS: In this prospective cohort of older adults with overweight/obesity and MetS, we found that improvements in dietary carbohydrate quality over a year were associated with concurrent favorable changes in visceral and overall fat deposition. These associations were mostly driven by dietary fibre and the wholegrain/total grain ratio. TRIAL REGISTRATION: The trial was registered at the International Standard Randomized. CONTROLLED TRIAL: (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.},
  author = {Zamanillo-Campos, R. and Chaplin, A. and Romaguera, D. and Abete, I. and Salas-Salvadó, J. and Martín, V. and Estruch, R. and Vidal, J. and Ruiz-Canela, M. and Babio, N. and Fiol, F. and de Paz, J. A. and Casas, R. and Olbeyra, R. and Martínez-González, M. A. and García-Gavilán, J. F. and Goday, A. and Fernandez-Lazaro, C. I. and Martínez, J. A. and Hu, F. B. and Konieczna, J.},
  journal = {Clin Nutr},
  keywords = {grapp-caib},
  number = 10,
  pages = {2264-2274},
  title = {Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators},
  type = {Journal Article},
  volume = 41,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN110
  %A Zamanillo-Campos, R.
  %A Chaplin, A.
  %A Romaguera, D.
  %A Abete, I.
  %A Salas-Salvadó, J.
  %A Martín, V.
  %A Estruch, R.
  %A Vidal, J.
  %A Ruiz-Canela, M.
  %A Babio, N.
  %A Fiol, F.
  %A de Paz, J. A.
  %A Casas, R.
  %A Olbeyra, R.
  %A Martínez-González, M. A.
  %A García-Gavilán, J. F.
  %A Goday, A.
  %A Fernandez-Lazaro, C. I.
  %A Martínez, J. A.
  %A Hu, F. B.
  %A Konieczna, J.
  %D 2022
  %J Clin Nutr
  %N 10
  %P 2264-2274
  %R 10.1016/j.clnu.2022.08.008
  %T Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators
  %V 41
  %X BACKGROUND & AIMS: The quality of dietary carbohydrates rather than total carbohydrate intake may determine the accumulation of visceral fat; however, to date, few studies have examined the impact of diet on adiposity using specific imaging techniques. Thus, the aim of this prospective study was to investigate the association between concurrent changes in carbohydrate quality index (CQI) and objectively-quantified adiposity distribution over a year. METHODS: We analyzed a cohort of 1476 participants aged 55-75 years with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus randomized controlled trial. Dietary intake information was obtained at baseline, 6- and 12-months from a validated 143-item semi-quantitative food-frequency questionnaire, and CQI (range: 4 to 20) was calculated based on four dietary criteria: total dietary fibre, glycemic index, wholegrain/total grain carbohydrate ratio, and solid/total carbohydrate ratio. Overall and regional adiposity (total body fat, visceral fat and android-to-gynoid fat ratio) was quantified using dual-energy X-ray absorptiometry at all three time points. Multiple adjusted linear mixed-effects models were used to assess associations between concurrent changes in repeatedly measured CQI and adiposity over time. RESULTS: After controlling for potential confounding factors, a 3-point increment in CQI over 12-month follow-up was associated with a decrease in visceral fat (β -0.067 z-score, 95% CI -0.088; -0.046, p < 0.001), android-to-gynoid fat ratio (-0.038, -0.059; -0.017, p < 0.001), and total fat (-0.064, -0.080; -0.047, p < 0.001). Fibre intake and the ratio of wholegrain/total grain showed the strongest inverse associations with all adiposity indicators. CONCLUSIONS: In this prospective cohort of older adults with overweight/obesity and MetS, we found that improvements in dietary carbohydrate quality over a year were associated with concurrent favorable changes in visceral and overall fat deposition. These associations were mostly driven by dietary fibre and the wholegrain/total grain ratio. TRIAL REGISTRATION: The trial was registered at the International Standard Randomized. CONTROLLED TRIAL: (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.
  

• 
  1.

  Gómez-Sánchez L, Rodríguez-Sánchez E, Ramos R, Marti R, Gómez-Sánchez M, Lugones-Sánchez C, Tamayo-Morales O, Sánchez SG, Rigo F, García-Ortiz L, Gómez-Marcos MA. Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study. Biol Sex Differ. 2022;13(1):46.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: The aim of this study was to analyze the association of physical activity and its intensity with arterial stiffness and vascular aging and differences by sex in a Spanish population with intermediate cardiovascular risk. METHODS: Cross-sectional study. A total of 2475 individuals aged 35-75 years participated in the study. Brachial-ankle pulse wave velocity (baPWV) was measured using a VaSera VS-1500(®) device. Based on the age and sex percentile presented by the participants, the latter were classified as follows: those with a percentile above 90 and presenting established cardiovascular disease were classified as early vascular aging (EVA); those with a percentile between 10 and 90 were classified as normal vascular aging (NVA) and those with a percentile below 10 were classified as healthy vascular aging (HVA). Physical activity was analyzed through the short version of the Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ). RESULTS: The mean age of the participants was 61.34 ± 7.70 years, with 61.60% men. Of the total sample, 86% were sedentary (83% men vs 90% women). The total physical activity showed a negative association with baPWV (β = - 0.045; 95% CI - 0.080 to - 0.009). Intense physical activity showed a negative relationship with baPWV (β = - 0.084; 95% CI - 0.136 to - 0.032). The OR of the total physical activity and the intense physical activity carried out by the subjects classified as NVA with respect to those classified as HVA was OR = 0.946; (95% CI 0.898 to 0.997) and OR = 0.903; (95% CI 0.840 to 0.971), and of those classified as EVA it was OR = 0.916; (95% CI 0.852 to 0.986) and OR = 0.905; (95% CI 0.818 to 1.000). No association was found with moderate- or low-intensity physical activity. CONCLUSIONS: The results of this study suggest that, when intense physical activity is performed, the probability of presenting vascular aging is lower. In the analysis by sex, this association is only observed in men.

  @article{RN97,
  abstract = {BACKGROUND: The aim of this study was to analyze the association of physical activity and its intensity with arterial stiffness and vascular aging and differences by sex in a Spanish population with intermediate cardiovascular risk. METHODS: Cross-sectional study. A total of 2475 individuals aged 35-75 years participated in the study. Brachial-ankle pulse wave velocity (baPWV) was measured using a VaSera VS-1500(®) device. Based on the age and sex percentile presented by the participants, the latter were classified as follows: those with a percentile above 90 and presenting established cardiovascular disease were classified as early vascular aging (EVA); those with a percentile between 10 and 90 were classified as normal vascular aging (NVA) and those with a percentile below 10 were classified as healthy vascular aging (HVA). Physical activity was analyzed through the short version of the Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ). RESULTS: The mean age of the participants was 61.34 ± 7.70 years, with 61.60% men. Of the total sample, 86% were sedentary (83% men vs 90% women). The total physical activity showed a negative association with baPWV (β = - 0.045; 95% CI - 0.080 to - 0.009). Intense physical activity showed a negative relationship with baPWV (β = - 0.084; 95% CI - 0.136 to - 0.032). The OR of the total physical activity and the intense physical activity carried out by the subjects classified as NVA with respect to those classified as HVA was OR = 0.946; (95% CI 0.898 to 0.997) and OR = 0.903; (95% CI 0.840 to 0.971), and of those classified as EVA it was OR = 0.916; (95% CI 0.852 to 0.986) and OR = 0.905; (95% CI 0.818 to 1.000). No association was found with moderate- or low-intensity physical activity. CONCLUSIONS: The results of this study suggest that, when intense physical activity is performed, the probability of presenting vascular aging is lower. In the analysis by sex, this association is only observed in men.},
  author = {Gómez-Sánchez, L. and Rodríguez-Sánchez, E. and Ramos, R. and Marti, R. and Gómez-Sánchez, M. and Lugones-Sánchez, C. and Tamayo-Morales, O. and Sánchez, S. G. and Rigo, F. and García-Ortiz, L. and Gómez-Marcos, M. A.},
  journal = {Biol Sex Differ},
  keywords = {grapp-caib},
  number = 1,
  pages = 46,
  title = {Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study},
  type = {Journal Article},
  volume = 13,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN97
  %A Gómez-Sánchez, L.
  %A Rodríguez-Sánchez, E.
  %A Ramos, R.
  %A Marti, R.
  %A Gómez-Sánchez, M.
  %A Lugones-Sánchez, C.
  %A Tamayo-Morales, O.
  %A Sánchez, S. G.
  %A Rigo, F.
  %A García-Ortiz, L.
  %A Gómez-Marcos, M. A.
  %D 2022
  %J Biol Sex Differ
  %N 1
  %P 46
  %R 10.1186/s13293-022-00456-w
  %T Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study
  %V 13
  %X BACKGROUND: The aim of this study was to analyze the association of physical activity and its intensity with arterial stiffness and vascular aging and differences by sex in a Spanish population with intermediate cardiovascular risk. METHODS: Cross-sectional study. A total of 2475 individuals aged 35-75 years participated in the study. Brachial-ankle pulse wave velocity (baPWV) was measured using a VaSera VS-1500(®) device. Based on the age and sex percentile presented by the participants, the latter were classified as follows: those with a percentile above 90 and presenting established cardiovascular disease were classified as early vascular aging (EVA); those with a percentile between 10 and 90 were classified as normal vascular aging (NVA) and those with a percentile below 10 were classified as healthy vascular aging (HVA). Physical activity was analyzed through the short version of the Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ). RESULTS: The mean age of the participants was 61.34 ± 7.70 years, with 61.60% men. Of the total sample, 86% were sedentary (83% men vs 90% women). The total physical activity showed a negative association with baPWV (β = - 0.045; 95% CI - 0.080 to - 0.009). Intense physical activity showed a negative relationship with baPWV (β = - 0.084; 95% CI - 0.136 to - 0.032). The OR of the total physical activity and the intense physical activity carried out by the subjects classified as NVA with respect to those classified as HVA was OR = 0.946; (95% CI 0.898 to 0.997) and OR = 0.903; (95% CI 0.840 to 0.971), and of those classified as EVA it was OR = 0.916; (95% CI 0.852 to 0.986) and OR = 0.905; (95% CI 0.818 to 1.000). No association was found with moderate- or low-intensity physical activity. CONCLUSIONS: The results of this study suggest that, when intense physical activity is performed, the probability of presenting vascular aging is lower. In the analysis by sex, this association is only observed in men.
  

• 
  1.

  Aguilar-Latorre A, Pérez Algorta G, Navarro-Guzmán C, Serrano-Ripoll MJ, Oliván-Blázquez B. Effectiveness of a lifestyle modification programme in the treatment of depression symptoms in primary care. Front Med (Lausanne). 2022;9:954644.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Depression symptoms are prevalent in the general population, and their onset and continuation may be related to biological and psychosocial factors, many of which are related to lifestyle aspects. Health promotion and lifestyle modification programmes (LMPs) may be effective on reducing the symptoms. The objective of this study was to analyse the clinical effectiveness of a LMP and a LMP plus Information and Communication Technologies, when compared to Treatment as Usual (TAU) over 6 months. The interventions were offered as an adjuvant treatment delivered in Primary Healthcare Centers (PHCs) for people with depression symptoms. METHODS: We conducted an open-label, multicentre, pragmatic, randomized clinical trial. Participants were recruited from several PHCs. Those participants visiting general practitioner for any reason, who also met the inclusion criteria (scoring 10 to 30 points on the Beck II Self-Applied Depression Inventory) were invited to take part in the study. TAU+LMP consisted of six weekly 90-min group sessions focused on improving lifestyle. TAU+LMP + ICTs replicated the TAU+LMP format, plus the addition of a wearable smartwatch to measure daily minutes walked and sleep patterns. A total of 188 participants consented to participate in the study and were randomized. We used linear mixed models, with a random intercept and an unstructured covariance to evaluate the impact of the interventions compared to TAU. RESULTS: Both interventions showed a statistically significant reduction on depressive symptoms compared to TAU (TAU+LMP vs. TAU slope difference, b = -3.38, 95% CI= [-5.286, -1.474] p = 0.001 and TAU+LMP+ICTs vs. TAU slope difference, b = -4.05, 95% CI = [-5.919, -2.197], p < 0.001). These reductions imply a moderate effect size. In the TAU+LMP+ICTs there was a significant increase regarding minutes walking per week (b = 99.77) and adherence to Mediterranean diet (b = 0.702). In the TAU+LMP there was a significant decrease regarding bad sleep quality (b = -1.24). CONCLUSION: TAU+LMPs administered in PHCs to people experiencing depression symptoms were effective on reducing these symptoms compared to TAU. They also have a positive impact on changing several lifestyle factors. These findings indicate that these interventions can be promising strategies for PHCs.

  @article{RN199,
  abstract = {BACKGROUND: Depression symptoms are prevalent in the general population, and their onset and continuation may be related to biological and psychosocial factors, many of which are related to lifestyle aspects. Health promotion and lifestyle modification programmes (LMPs) may be effective on reducing the symptoms. The objective of this study was to analyse the clinical effectiveness of a LMP and a LMP plus Information and Communication Technologies, when compared to Treatment as Usual (TAU) over 6 months. The interventions were offered as an adjuvant treatment delivered in Primary Healthcare Centers (PHCs) for people with depression symptoms. METHODS: We conducted an open-label, multicentre, pragmatic, randomized clinical trial. Participants were recruited from several PHCs. Those participants visiting general practitioner for any reason, who also met the inclusion criteria (scoring 10 to 30 points on the Beck II Self-Applied Depression Inventory) were invited to take part in the study. TAU+LMP consisted of six weekly 90-min group sessions focused on improving lifestyle. TAU+LMP + ICTs replicated the TAU+LMP format, plus the addition of a wearable smartwatch to measure daily minutes walked and sleep patterns. A total of 188 participants consented to participate in the study and were randomized. We used linear mixed models, with a random intercept and an unstructured covariance to evaluate the impact of the interventions compared to TAU. RESULTS: Both interventions showed a statistically significant reduction on depressive symptoms compared to TAU (TAU+LMP vs. TAU slope difference, b = -3.38, 95% CI= [-5.286, -1.474] p = 0.001 and TAU+LMP+ICTs vs. TAU slope difference, b = -4.05, 95% CI = [-5.919, -2.197], p < 0.001). These reductions imply a moderate effect size. In the TAU+LMP+ICTs there was a significant increase regarding minutes walking per week (b = 99.77) and adherence to Mediterranean diet (b = 0.702). In the TAU+LMP there was a significant decrease regarding bad sleep quality (b = -1.24). CONCLUSION: TAU+LMPs administered in PHCs to people experiencing depression symptoms were effective on reducing these symptoms compared to TAU. They also have a positive impact on changing several lifestyle factors. These findings indicate that these interventions can be promising strategies for PHCs.},
  author = {Aguilar-Latorre, A. and Pérez Algorta, G. and Navarro-Guzmán, C. and Serrano-Ripoll, M. J. and Oliván-Blázquez, B.},
  journal = {Front Med (Lausanne)},
  keywords = {grapp-caib},
  pages = 954644,
  title = {Effectiveness of a lifestyle modification programme in the treatment of depression symptoms in primary care},
  type = {Journal Article},
  volume = 9,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN199
  %A Aguilar-Latorre, A.
  %A Pérez Algorta, G.
  %A Navarro-Guzmán, C.
  %A Serrano-Ripoll, M. J.
  %A Oliván-Blázquez, B.
  %D 2022
  %J Front Med (Lausanne)
  %P 954644
  %R 10.3389/fmed.2022.954644
  %T Effectiveness of a lifestyle modification programme in the treatment of depression symptoms in primary care
  %V 9
  %X BACKGROUND: Depression symptoms are prevalent in the general population, and their onset and continuation may be related to biological and psychosocial factors, many of which are related to lifestyle aspects. Health promotion and lifestyle modification programmes (LMPs) may be effective on reducing the symptoms. The objective of this study was to analyse the clinical effectiveness of a LMP and a LMP plus Information and Communication Technologies, when compared to Treatment as Usual (TAU) over 6 months. The interventions were offered as an adjuvant treatment delivered in Primary Healthcare Centers (PHCs) for people with depression symptoms. METHODS: We conducted an open-label, multicentre, pragmatic, randomized clinical trial. Participants were recruited from several PHCs. Those participants visiting general practitioner for any reason, who also met the inclusion criteria (scoring 10 to 30 points on the Beck II Self-Applied Depression Inventory) were invited to take part in the study. TAU+LMP consisted of six weekly 90-min group sessions focused on improving lifestyle. TAU+LMP + ICTs replicated the TAU+LMP format, plus the addition of a wearable smartwatch to measure daily minutes walked and sleep patterns. A total of 188 participants consented to participate in the study and were randomized. We used linear mixed models, with a random intercept and an unstructured covariance to evaluate the impact of the interventions compared to TAU. RESULTS: Both interventions showed a statistically significant reduction on depressive symptoms compared to TAU (TAU+LMP vs. TAU slope difference, b = -3.38, 95% CI= [-5.286, -1.474] p = 0.001 and TAU+LMP+ICTs vs. TAU slope difference, b = -4.05, 95% CI = [-5.919, -2.197], p < 0.001). These reductions imply a moderate effect size. In the TAU+LMP+ICTs there was a significant increase regarding minutes walking per week (b = 99.77) and adherence to Mediterranean diet (b = 0.702). In the TAU+LMP there was a significant decrease regarding bad sleep quality (b = -1.24). CONCLUSION: TAU+LMPs administered in PHCs to people experiencing depression symptoms were effective on reducing these symptoms compared to TAU. They also have a positive impact on changing several lifestyle factors. These findings indicate that these interventions can be promising strategies for PHCs.
  

• 
  1.

  Esteva M, Leiva A, Ramos-Monserrat M, Espí A, González-Luján L, Macià F, Murta-Nascimento C, Sánchez-Calavera MA, Magallón R, Balboa-Barreiro V, Seoane-Pillado T, Pertega-Díaz S. Relationship between time from symptom’s onset to diagnosis and prognosis in patients with symptomatic colorectal cancer. BMC Cancer. 2022;22(1):910.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Controversy exists regarding the relationship of the outcome of patients with colorectal cancer (CRC) with the time from symptom onset to diagnosis. The aim of this study is to investigate this association, with the assumption that this relationship was nonlinear and with adjustment for multiple confounders, such as tumor grade, symptoms, or admission to an emergency department. METHODS: This multicenter study with prospective follow-up was performed in five regions of Spain from 2010 to 2012. Symptomatic cases of incident CRC from a previous study were examined. At the time of diagnosis, each patient was interviewed, and the associated hospital and clinical records were reviewed. During follow-up, the clinical records were reviewed again to assess survival. Cox survival analysis with a restricted cubic spline was used to model overall and CRC-specific survival, with adjustment for variables related to the patient, health service, and tumor. RESULTS: A total of 795 patients had symptomatic CRC and 769 of them had complete data on diagnostic delay and survival. Univariate analysis indicated a lower HR for death in patients who had diagnostic intervals less than 4.2 months. However, after adjustment for variables related to the patient, tumor, and utilized health service, there was no relationship of the diagnostic delay with survival of patients with colon and rectal cancer, colon cancer alone, or rectal cancer alone. Cubic spline analysis indicated an inverse association of the diagnostic delay with 5-year survival. However, this association was not statistically significant. CONCLUSIONS: Our results indicated that the duration of diagnostic delay had no significant effect on the outcome of patients with CRC. We suggest that the most important determinant of the duration of diagnostic delay is the biological profile of the tumor. However, it remains the responsibility of community health centers and authorities to minimize diagnostic delays in patients with CRC and to implement initiatives that improve early diagnosis and provide better outcomes.

  @article{RN99,
  abstract = {BACKGROUND: Controversy exists regarding the relationship of the outcome of patients with colorectal cancer (CRC) with the time from symptom onset to diagnosis. The aim of this study is to investigate this association, with the assumption that this relationship was nonlinear and with adjustment for multiple confounders, such as tumor grade, symptoms, or admission to an emergency department. METHODS: This multicenter study with prospective follow-up was performed in five regions of Spain from 2010 to 2012. Symptomatic cases of incident CRC from a previous study were examined. At the time of diagnosis, each patient was interviewed, and the associated hospital and clinical records were reviewed. During follow-up, the clinical records were reviewed again to assess survival. Cox survival analysis with a restricted cubic spline was used to model overall and CRC-specific survival, with adjustment for variables related to the patient, health service, and tumor. RESULTS: A total of 795 patients had symptomatic CRC and 769 of them had complete data on diagnostic delay and survival. Univariate analysis indicated a lower HR for death in patients who had diagnostic intervals less than 4.2 months. However, after adjustment for variables related to the patient, tumor, and utilized health service, there was no relationship of the diagnostic delay with survival of patients with colon and rectal cancer, colon cancer alone, or rectal cancer alone. Cubic spline analysis indicated an inverse association of the diagnostic delay with 5-year survival. However, this association was not statistically significant. CONCLUSIONS: Our results indicated that the duration of diagnostic delay had no significant effect on the outcome of patients with CRC. We suggest that the most important determinant of the duration of diagnostic delay is the biological profile of the tumor. However, it remains the responsibility of community health centers and authorities to minimize diagnostic delays in patients with CRC and to implement initiatives that improve early diagnosis and provide better outcomes.},
  author = {Esteva, M. and Leiva, A. and Ramos-Monserrat, M. and Espí, A. and González-Luján, L. and Macià, F. and Murta-Nascimento, C. and Sánchez-Calavera, M. A. and Magallón, R. and Balboa-Barreiro, V. and Seoane-Pillado, T. and Pertega-Díaz, S.},
  journal = {BMC Cancer},
  keywords = {grapp-caib},
  number = 1,
  pages = 910,
  title = {Relationship between time from symptom's onset to diagnosis and prognosis in patients with symptomatic colorectal cancer},
  type = {Journal Article},
  volume = 22,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN99
  %A Esteva, M.
  %A Leiva, A.
  %A Ramos-Monserrat, M.
  %A Espí, A.
  %A González-Luján, L.
  %A Macià, F.
  %A Murta-Nascimento, C.
  %A Sánchez-Calavera, M. A.
  %A Magallón, R.
  %A Balboa-Barreiro, V.
  %A Seoane-Pillado, T.
  %A Pertega-Díaz, S.
  %D 2022
  %J BMC Cancer
  %N 1
  %P 910
  %R 10.1186/s12885-022-09990-7
  %T Relationship between time from symptom's onset to diagnosis and prognosis in patients with symptomatic colorectal cancer
  %V 22
  %X BACKGROUND: Controversy exists regarding the relationship of the outcome of patients with colorectal cancer (CRC) with the time from symptom onset to diagnosis. The aim of this study is to investigate this association, with the assumption that this relationship was nonlinear and with adjustment for multiple confounders, such as tumor grade, symptoms, or admission to an emergency department. METHODS: This multicenter study with prospective follow-up was performed in five regions of Spain from 2010 to 2012. Symptomatic cases of incident CRC from a previous study were examined. At the time of diagnosis, each patient was interviewed, and the associated hospital and clinical records were reviewed. During follow-up, the clinical records were reviewed again to assess survival. Cox survival analysis with a restricted cubic spline was used to model overall and CRC-specific survival, with adjustment for variables related to the patient, health service, and tumor. RESULTS: A total of 795 patients had symptomatic CRC and 769 of them had complete data on diagnostic delay and survival. Univariate analysis indicated a lower HR for death in patients who had diagnostic intervals less than 4.2 months. However, after adjustment for variables related to the patient, tumor, and utilized health service, there was no relationship of the diagnostic delay with survival of patients with colon and rectal cancer, colon cancer alone, or rectal cancer alone. Cubic spline analysis indicated an inverse association of the diagnostic delay with 5-year survival. However, this association was not statistically significant. CONCLUSIONS: Our results indicated that the duration of diagnostic delay had no significant effect on the outcome of patients with CRC. We suggest that the most important determinant of the duration of diagnostic delay is the biological profile of the tumor. However, it remains the responsibility of community health centers and authorities to minimize diagnostic delays in patients with CRC and to implement initiatives that improve early diagnosis and provide better outcomes.
  

• 
  1.

  López-González AA, Jover AM, Martínez CS, Artal PM, Bote SA, Jané BA, Ramírez-Manent JI. The CUN-BAE, Deurenberg Fat Mass, and visceral adiposity index as confident anthropometric indices for early detection of metabolic syndrome components in adults. Sci Rep. 2022;12(1):15486.

  AbstractBibTeXEndNoteDOIBibSonomy

  There is no definition for the metabolic syndrome; visceral obesity, elevated lipids and glucose, and hypertension coexist. The aim of the study is to determine which anthropometric indicators best determine it. Cross-sectional study in 418,343 Spanish workers. Metabolic syndrome was determined using the NCEP-ATPIII, IDF and JIS criteria. The anthropometric variables studied were: body mass index, waist circumference, waist-to-height ratio, CUNBAE, Deuremberg formula, body fat index, body surface index, normalized weight adjusted index, body roundness index, body shape index, visceral adiposity index (VAI), dysfunctional adiposity index, conicity index, metabolic score for visceral fat (METS-VF), waist triglyceride index. In men, the anthropometric indices with the largest areas under the ROC curve are VAI with ATPIII criteria and JIS. If we use the IDF criteria: waist circumference and METS-VF, with the same result. In women, the largest areas under the curve were observed with the Deuremberg formula in both ATPIII and JIS while with the IDF criteria it is METS-VF. The most useful anthropometric indices for identifying metabolic syndrome are CUN-BAE and Deuremberg, followed by the VAI. A single definition of metabolic syndrome should be agreed to determine the best anthropometric index with predictive capacity for its diagnosis.

  @article{RN1,
  abstract = {There is no definition for the metabolic syndrome; visceral obesity, elevated lipids and glucose, and hypertension coexist. The aim of the study is to determine which anthropometric indicators best determine it. Cross-sectional study in 418,343 Spanish workers. Metabolic syndrome was determined using the NCEP-ATPIII, IDF and JIS criteria. The anthropometric variables studied were: body mass index, waist circumference, waist-to-height ratio, CUNBAE, Deuremberg formula, body fat index, body surface index, normalized weight adjusted index, body roundness index, body shape index, visceral adiposity index (VAI), dysfunctional adiposity index, conicity index, metabolic score for visceral fat (METS-VF), waist triglyceride index. In men, the anthropometric indices with the largest areas under the ROC curve are VAI with ATPIII criteria and JIS. If we use the IDF criteria: waist circumference and METS-VF, with the same result. In women, the largest areas under the curve were observed with the Deuremberg formula in both ATPIII and JIS while with the IDF criteria it is METS-VF. The most useful anthropometric indices for identifying metabolic syndrome are CUN-BAE and Deuremberg, followed by the VAI. A single definition of metabolic syndrome should be agreed to determine the best anthropometric index with predictive capacity for its diagnosis.},
  author = {López-González, A. A. and Jover, A. M. and Martínez, C. S. and Artal, P. M. and Bote, S. A. and Jané, B. A. and Ramírez-Manent, J. I.},
  journal = {Sci Rep},
  keywords = {grapp-caib},
  number = 1,
  pages = 15486,
  title = {The CUN-BAE, Deurenberg Fat Mass, and visceral adiposity index as confident anthropometric indices for early detection of metabolic syndrome components in adults},
  type = {Journal Article},
  volume = 12,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN1
  %A López-González, A. A.
  %A Jover, A. M.
  %A Martínez, C. S.
  %A Artal, P. M.
  %A Bote, S. A.
  %A Jané, B. A.
  %A Ramírez-Manent, J. I.
  %D 2022
  %J Sci Rep
  %N 1
  %P 15486
  %R 10.1038/s41598-022-19343-w
  %T The CUN-BAE, Deurenberg Fat Mass, and visceral adiposity index as confident anthropometric indices for early detection of metabolic syndrome components in adults
  %V 12
  %X There is no definition for the metabolic syndrome; visceral obesity, elevated lipids and glucose, and hypertension coexist. The aim of the study is to determine which anthropometric indicators best determine it. Cross-sectional study in 418,343 Spanish workers. Metabolic syndrome was determined using the NCEP-ATPIII, IDF and JIS criteria. The anthropometric variables studied were: body mass index, waist circumference, waist-to-height ratio, CUNBAE, Deuremberg formula, body fat index, body surface index, normalized weight adjusted index, body roundness index, body shape index, visceral adiposity index (VAI), dysfunctional adiposity index, conicity index, metabolic score for visceral fat (METS-VF), waist triglyceride index. In men, the anthropometric indices with the largest areas under the ROC curve are VAI with ATPIII criteria and JIS. If we use the IDF criteria: waist circumference and METS-VF, with the same result. In women, the largest areas under the curve were observed with the Deuremberg formula in both ATPIII and JIS while with the IDF criteria it is METS-VF. The most useful anthropometric indices for identifying metabolic syndrome are CUN-BAE and Deuremberg, followed by the VAI. A single definition of metabolic syndrome should be agreed to determine the best anthropometric index with predictive capacity for its diagnosis.
  

• 
  1.

  Ramírez-Manent JI, Altisench Jané B, Tomás Salvà M, Arroyo Bote S, González San Miguel HM, López-González Á A. Influence of Educational Level and Healthy Habits on the Prevalence of Diabesity in a Spanish Working Population. Nutrients. 2022;14(19).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Diabesity is a growing problem internationally. Taking into account the importance of physical activity and diet in its prevention and treatment, the objective of this study was to delve into the impact of healthy habits on diabesity. METHODS: A descriptive, cross-sectional study was carried out in 386,924 Spanish adult workers. Obesity was determined according to eleven different formulas. Life habits were also valued; sociodemographic variables; and educational level; as well as analytical and clinical variables such as blood pressure and blood glucose levels. The association between the different variables was performed using the chi-square and the Student's t-tests when the samples were independent. A multivariate analysis was performed using the multinomial logistic regression test by calculating the odds ratio and a 95% confidence interval. The Hosmer-Lemeshow goodness-of-fit test was also performed. RESULTS: The overall prevalence of diabesity ranged between 0.3% (95% CI 0.3-0.4) when obesity was assessed according to the abdominal volume index and 8.3% (95% CI 8.2-8.4) when evaluated according to the CUN-BAE (Clínica Universitaria de Navarra Body Adiposity Estimator) formula. The prevalence of diabesity was also higher in workers with a non-heart-healthy diet and in those who did not exercise regularly. CONCLUSIONS: The most disadvantaged socioeconomic classes are those with the highest prevalence of diabesity. It is important to prioritise prevention in populations and communities with the most unfavourable social and environmental conditions to reduce the burden of diabesity.

  @article{RN112,
  abstract = {BACKGROUND: Diabesity is a growing problem internationally. Taking into account the importance of physical activity and diet in its prevention and treatment, the objective of this study was to delve into the impact of healthy habits on diabesity. METHODS: A descriptive, cross-sectional study was carried out in 386,924 Spanish adult workers. Obesity was determined according to eleven different formulas. Life habits were also valued; sociodemographic variables; and educational level; as well as analytical and clinical variables such as blood pressure and blood glucose levels. The association between the different variables was performed using the chi-square and the Student's t-tests when the samples were independent. A multivariate analysis was performed using the multinomial logistic regression test by calculating the odds ratio and a 95% confidence interval. The Hosmer-Lemeshow goodness-of-fit test was also performed. RESULTS: The overall prevalence of diabesity ranged between 0.3% (95% CI 0.3-0.4) when obesity was assessed according to the abdominal volume index and 8.3% (95% CI 8.2-8.4) when evaluated according to the CUN-BAE (Clínica Universitaria de Navarra Body Adiposity Estimator) formula. The prevalence of diabesity was also higher in workers with a non-heart-healthy diet and in those who did not exercise regularly. CONCLUSIONS: The most disadvantaged socioeconomic classes are those with the highest prevalence of diabesity. It is important to prioritise prevention in populations and communities with the most unfavourable social and environmental conditions to reduce the burden of diabesity.},
  author = {Ramírez-Manent, J. I. and Altisench Jané, B. and Tomás Salvà, M. and Arroyo Bote, S. and González San Miguel, H. M. and López-González Á, A.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  number = 19,
  title = {Influence of Educational Level and Healthy Habits on the Prevalence of Diabesity in a Spanish Working Population},
  type = {Journal Article},
  volume = 14,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN112
  %A Ramírez-Manent, J. I.
  %A Altisench Jané, B.
  %A Tomás Salvà, M.
  %A Arroyo Bote, S.
  %A González San Miguel, H. M.
  %A López-González Á, A.
  %D 2022
  %J Nutrients
  %N 19
  %R 10.3390/nu14194101
  %T Influence of Educational Level and Healthy Habits on the Prevalence of Diabesity in a Spanish Working Population
  %V 14
  %X BACKGROUND: Diabesity is a growing problem internationally. Taking into account the importance of physical activity and diet in its prevention and treatment, the objective of this study was to delve into the impact of healthy habits on diabesity. METHODS: A descriptive, cross-sectional study was carried out in 386,924 Spanish adult workers. Obesity was determined according to eleven different formulas. Life habits were also valued; sociodemographic variables; and educational level; as well as analytical and clinical variables such as blood pressure and blood glucose levels. The association between the different variables was performed using the chi-square and the Student's t-tests when the samples were independent. A multivariate analysis was performed using the multinomial logistic regression test by calculating the odds ratio and a 95% confidence interval. The Hosmer-Lemeshow goodness-of-fit test was also performed. RESULTS: The overall prevalence of diabesity ranged between 0.3% (95% CI 0.3-0.4) when obesity was assessed according to the abdominal volume index and 8.3% (95% CI 8.2-8.4) when evaluated according to the CUN-BAE (Clínica Universitaria de Navarra Body Adiposity Estimator) formula. The prevalence of diabesity was also higher in workers with a non-heart-healthy diet and in those who did not exercise regularly. CONCLUSIONS: The most disadvantaged socioeconomic classes are those with the highest prevalence of diabesity. It is important to prioritise prevention in populations and communities with the most unfavourable social and environmental conditions to reduce the burden of diabesity.
  

• 
  1.

  León-Salas B, Álvarez-Pérez Y, Ramos-García V, Del Mar Trujillo-Martín M, de Pascual YMAM, Esteva M, Brito-García N, González-Hernández N, Bohn-Sarmiento U, Biurrun-Martínez MC, Serrano-Aguilar P. Information needs and research priorities in long-term survivorship of breast cancer: Patients and health professionals’ perspectives. Eur J Cancer Care (Engl). 2022;:e13730.

  AbstractBibTeXEndNoteDOIBibSonomy

  OBJECTIVE: The objective of this work is to identify unmet information needs of long-term-survivors of breast cancer (BC) and future research needs from the perspectives of patients and health care professionals. METHODS: Two online Delphi surveys were conducted. Participants in Survey 1 were patients. Participants in Survey 2 were health care professionals from both primary and secondary care involved in BC care. Both surveys included three successive rounds. The first round aimed to identify research and information needs; the second round aimed to rank the relative importance of those needs; the third round aimed to find consensus. RESULTS: The most important information needs were self-management recommendations of common health problems after treatment and complications of breast reconstruction after 5 years. The most important research priorities were related to interventions and tools to increase information provision by professionals about certain tests, diet, and coordinated action between primary and specialised care during follow-up, and indications and safety issues of pregnancy in survivors. CONCLUSIONS: Two fundamental ideas were identified: (1) Patients request information about self-management common health problems after treatment and breast reconstruction complications. (2) Health care professionals emphasise the need for a standardised approach based on protocols, recommendations, and coordinated actions in the provision of information. IMPLICATIONS FOR CANCER SURVIVORS: Given the increasing number of BC survivors, it is essential to identify information and research needs to improve their care and health outcomes.

  @article{RN113,
  abstract = {OBJECTIVE: The objective of this work is to identify unmet information needs of long-term-survivors of breast cancer (BC) and future research needs from the perspectives of patients and health care professionals. METHODS: Two online Delphi surveys were conducted. Participants in Survey 1 were patients. Participants in Survey 2 were health care professionals from both primary and secondary care involved in BC care. Both surveys included three successive rounds. The first round aimed to identify research and information needs; the second round aimed to rank the relative importance of those needs; the third round aimed to find consensus. RESULTS: The most important information needs were self-management recommendations of common health problems after treatment and complications of breast reconstruction after 5 years. The most important research priorities were related to interventions and tools to increase information provision by professionals about certain tests, diet, and coordinated action between primary and specialised care during follow-up, and indications and safety issues of pregnancy in survivors. CONCLUSIONS: Two fundamental ideas were identified: (1) Patients request information about self-management common health problems after treatment and breast reconstruction complications. (2) Health care professionals emphasise the need for a standardised approach based on protocols, recommendations, and coordinated actions in the provision of information. IMPLICATIONS FOR CANCER SURVIVORS: Given the increasing number of BC survivors, it is essential to identify information and research needs to improve their care and health outcomes.},
  author = {León-Salas, B. and Álvarez-Pérez, Y. and Ramos-García, V. and Del Mar Trujillo-Martín, M. and de Pascual, Y. Medina A. M. and Esteva, M. and Brito-García, N. and González-Hernández, N. and Bohn-Sarmiento, U. and Biurrun-Martínez, M. C. and Serrano-Aguilar, P.},
  journal = {Eur J Cancer Care (Engl)},
  keywords = {grapp-caib},
  pages = {e13730},
  title = {Information needs and research priorities in long-term survivorship of breast cancer: Patients and health professionals' perspectives},
  type = {Journal Article},
  year = 2022
  }
  

  %0 Journal Article
  %1 RN113
  %A León-Salas, B.
  %A Álvarez-Pérez, Y.
  %A Ramos-García, V.
  %A Del Mar Trujillo-Martín, M.
  %A de Pascual, Y. Medina A. M.
  %A Esteva, M.
  %A Brito-García, N.
  %A González-Hernández, N.
  %A Bohn-Sarmiento, U.
  %A Biurrun-Martínez, M. C.
  %A Serrano-Aguilar, P.
  %D 2022
  %J Eur J Cancer Care (Engl)
  %P e13730
  %R 10.1111/ecc.13730
  %T Information needs and research priorities in long-term survivorship of breast cancer: Patients and health professionals' perspectives
  %X OBJECTIVE: The objective of this work is to identify unmet information needs of long-term-survivors of breast cancer (BC) and future research needs from the perspectives of patients and health care professionals. METHODS: Two online Delphi surveys were conducted. Participants in Survey 1 were patients. Participants in Survey 2 were health care professionals from both primary and secondary care involved in BC care. Both surveys included three successive rounds. The first round aimed to identify research and information needs; the second round aimed to rank the relative importance of those needs; the third round aimed to find consensus. RESULTS: The most important information needs were self-management recommendations of common health problems after treatment and complications of breast reconstruction after 5 years. The most important research priorities were related to interventions and tools to increase information provision by professionals about certain tests, diet, and coordinated action between primary and specialised care during follow-up, and indications and safety issues of pregnancy in survivors. CONCLUSIONS: Two fundamental ideas were identified: (1) Patients request information about self-management common health problems after treatment and breast reconstruction complications. (2) Health care professionals emphasise the need for a standardised approach based on protocols, recommendations, and coordinated actions in the provision of information. IMPLICATIONS FOR CANCER SURVIVORS: Given the increasing number of BC survivors, it is essential to identify information and research needs to improve their care and health outcomes.
  

• 
  1.

  Gómez-Gómez I, Benítez I, Bellón J, Moreno-Peral P, Oliván-Blázquez B, Clavería A, Zabaleta-Del-Olmo E, Llobera J, Serrano-Ripoll MJ, Tamayo-Morales O, Motrico E. Utility of PHQ-2, PHQ-8 and PHQ-9 for detecting major depression in primary health care: a validation study in Spain. Psychol Med. 2022;:1-11.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Primary health care (PHC) professionals may play a crucial role in improving early diagnosis of depressive disorders. However, only 50% of cases are detected in PHC. The most widely used screening instrument for major depression is the Patient Health Questionnaire (PHQ), including the two-, eight- and nine-item versions. Surprisingly, there is neither enough evidence about the validity of PHQ in PHC patients in Spain nor indications about how to interpret the total scores. This study aimed to gather validity evidence to support the use of the three PHQ versions to screen for major depression in PHC in Spain. Additionally, the present study provided information for helping professionals to choose the best PHQ version according to the context. METHODS: The sample was composed of 2579 participants from 22 Spanish PHC centers participating in the EIRA-3 study. The reliability and validity of the three PHQ versions for Spanish PHC patients were assessed based on responses to the questionnaire. RESULTS: The PHQ-8 and PHQ-9 showed high internal consistency. The results obtained confirm the theoretically expected relationship between PHQ results and anxiety, social support and health-related QoL. A single-factor solution was confirmed. Regarding to the level of agreement with the CIDI interview (used as the criterion), our results indicate that the PHQ has a good discrimination power. The optimal cut-off values were: ⩾2 for PHQ-2, ⩾7 for PHQ-8 and ⩾8 for PHQ-9. CONCLUSIONS: PHQ is a good and valuable tool for detecting major depression in PHC patients in Spain.

  @article{RN115,
  abstract = {BACKGROUND: Primary health care (PHC) professionals may play a crucial role in improving early diagnosis of depressive disorders. However, only 50% of cases are detected in PHC. The most widely used screening instrument for major depression is the Patient Health Questionnaire (PHQ), including the two-, eight- and nine-item versions. Surprisingly, there is neither enough evidence about the validity of PHQ in PHC patients in Spain nor indications about how to interpret the total scores. This study aimed to gather validity evidence to support the use of the three PHQ versions to screen for major depression in PHC in Spain. Additionally, the present study provided information for helping professionals to choose the best PHQ version according to the context. METHODS: The sample was composed of 2579 participants from 22 Spanish PHC centers participating in the EIRA-3 study. The reliability and validity of the three PHQ versions for Spanish PHC patients were assessed based on responses to the questionnaire. RESULTS: The PHQ-8 and PHQ-9 showed high internal consistency. The results obtained confirm the theoretically expected relationship between PHQ results and anxiety, social support and health-related QoL. A single-factor solution was confirmed. Regarding to the level of agreement with the CIDI interview (used as the criterion), our results indicate that the PHQ has a good discrimination power. The optimal cut-off values were: ⩾2 for PHQ-2, ⩾7 for PHQ-8 and ⩾8 for PHQ-9. CONCLUSIONS: PHQ is a good and valuable tool for detecting major depression in PHC patients in Spain.},
  author = {Gómez-Gómez, I. and Benítez, I. and Bellón, J. and Moreno-Peral, P. and Oliván-Blázquez, B. and Clavería, A. and Zabaleta-Del-Olmo, E. and Llobera, J. and Serrano-Ripoll, M. J. and Tamayo-Morales, O. and Motrico, E.},
  journal = {Psychol Med},
  keywords = {grapp-caib},
  pages = {1-11},
  title = {Utility of PHQ-2, PHQ-8 and PHQ-9 for detecting major depression in primary health care: a validation study in Spain},
  type = {Journal Article},
  year = 2022
  }
  

  %0 Journal Article
  %1 RN115
  %A Gómez-Gómez, I.
  %A Benítez, I.
  %A Bellón, J.
  %A Moreno-Peral, P.
  %A Oliván-Blázquez, B.
  %A Clavería, A.
  %A Zabaleta-Del-Olmo, E.
  %A Llobera, J.
  %A Serrano-Ripoll, M. J.
  %A Tamayo-Morales, O.
  %A Motrico, E.
  %D 2022
  %J Psychol Med
  %P 1-11
  %R 10.1017/s0033291722002835
  %T Utility of PHQ-2, PHQ-8 and PHQ-9 for detecting major depression in primary health care: a validation study in Spain
  %X BACKGROUND: Primary health care (PHC) professionals may play a crucial role in improving early diagnosis of depressive disorders. However, only 50% of cases are detected in PHC. The most widely used screening instrument for major depression is the Patient Health Questionnaire (PHQ), including the two-, eight- and nine-item versions. Surprisingly, there is neither enough evidence about the validity of PHQ in PHC patients in Spain nor indications about how to interpret the total scores. This study aimed to gather validity evidence to support the use of the three PHQ versions to screen for major depression in PHC in Spain. Additionally, the present study provided information for helping professionals to choose the best PHQ version according to the context. METHODS: The sample was composed of 2579 participants from 22 Spanish PHC centers participating in the EIRA-3 study. The reliability and validity of the three PHQ versions for Spanish PHC patients were assessed based on responses to the questionnaire. RESULTS: The PHQ-8 and PHQ-9 showed high internal consistency. The results obtained confirm the theoretically expected relationship between PHQ results and anxiety, social support and health-related QoL. A single-factor solution was confirmed. Regarding to the level of agreement with the CIDI interview (used as the criterion), our results indicate that the PHQ has a good discrimination power. The optimal cut-off values were: ⩾2 for PHQ-2, ⩾7 for PHQ-8 and ⩾8 for PHQ-9. CONCLUSIONS: PHQ is a good and valuable tool for detecting major depression in PHC patients in Spain.
  

• 
  1.

  Moliner-Calderón E, Verd S, Leiva A, Ponce-Taylor J, Ginovart G, Moll-McCarthy P, Gelabert C, Figueras-Aloy J. Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy. Children (Basel). 2022;9(10).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. METHODS: All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. RESULTS: The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. CONCLUSION: Human milk feeding may minimize exposure to mechanical ventilation.

  @article{RN117,
  abstract = {BACKGROUND: It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. METHODS: All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. RESULTS: The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. CONCLUSION: Human milk feeding may minimize exposure to mechanical ventilation.},
  author = {Moliner-Calderón, E. and Verd, S. and Leiva, A. and Ponce-Taylor, J. and Ginovart, G. and Moll-McCarthy, P. and Gelabert, C. and Figueras-Aloy, J.},
  journal = {Children (Basel)},
  keywords = {grapp-caib},
  number = 10,
  title = {Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy},
  type = {Journal Article},
  volume = 9,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN117
  %A Moliner-Calderón, E.
  %A Verd, S.
  %A Leiva, A.
  %A Ponce-Taylor, J.
  %A Ginovart, G.
  %A Moll-McCarthy, P.
  %A Gelabert, C.
  %A Figueras-Aloy, J.
  %D 2022
  %J Children (Basel)
  %N 10
  %R 10.3390/children9101450
  %T Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
  %V 9
  %X BACKGROUND: It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. METHODS: All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. RESULTS: The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. CONCLUSION: Human milk feeding may minimize exposure to mechanical ventilation.
  

• 
  1.

  Jané BA, Ramírez-Manent JI, Bote SA, Sbert PR, González San Mıguel HM, Lopez González Á A. Determination of cardiovascular risk in 192,711 underweight and normal weight workers. Turk J Med Sci. 2022;52(4):926-33.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: The aim of this study was to determine the prevalence of cardiovascular risk factors (CVRF) and the level of cardiovascular risk (CVR), determined with different scales (REGICOR, SCORE, ERICE, vascular age...) in people with low and normal weight. METHODS: A total of 192,711 underweight and normal weight Spanish workers participated. CVR parameters included were weight, abdominal circumference, blood pressure, glycemia (high >125 mg/dL or under hypoglycemic treatment) and lipids (cutoff points: total cholesterol 200 mg/dL, LDL 130 mg/dL, triglycerides 150 mg/dL) were obtained by automated enzymatic methods. Body mass index (BMI) was calculated, considering underweight 18.5 and normal weight 18.5-24.9. A descriptive analysis of the categorical variables was carried out. RESULTS: The values of analytical, anthropometric and clinical parameters were more unfavorable in the normal weight group. Also, the prevalence of alterated values of CVR seen with different scales show higher risk in this group and in all cases the values in men are worse. It was seen that the variable with the greatest influence on the appearance of altered values of the cardiovascular risk scales (CVRS), influencing all of them was the age. DISCUSSION: All the CVRS analyzed showed higher values in the group of people with normal weight compared to those with underweight. Age, followed by sex, were the variables that most influence the appearance of high CVR values.

  @article{RN1,
  abstract = {BACKGROUND: The aim of this study was to determine the prevalence of cardiovascular risk factors (CVRF) and the level of cardiovascular risk (CVR), determined with different scales (REGICOR, SCORE, ERICE, vascular age...) in people with low and normal weight. METHODS: A total of 192,711 underweight and normal weight Spanish workers participated. CVR parameters included were weight, abdominal circumference, blood pressure, glycemia (high >125 mg/dL or under hypoglycemic treatment) and lipids (cutoff points: total cholesterol 200 mg/dL, LDL 130 mg/dL, triglycerides 150 mg/dL) were obtained by automated enzymatic methods. Body mass index (BMI) was calculated, considering underweight 18.5 and normal weight 18.5-24.9. A descriptive analysis of the categorical variables was carried out. RESULTS: The values of analytical, anthropometric and clinical parameters were more unfavorable in the normal weight group. Also, the prevalence of alterated values of CVR seen with different scales show higher risk in this group and in all cases the values in men are worse. It was seen that the variable with the greatest influence on the appearance of altered values of the cardiovascular risk scales (CVRS), influencing all of them was the age. DISCUSSION: All the CVRS analyzed showed higher values in the group of people with normal weight compared to those with underweight. Age, followed by sex, were the variables that most influence the appearance of high CVR values.},
  author = {Jané, B. A. and Ramírez-Manent, J. I. and Bote, S. A. and Sbert, P. R. and González San Mıguel, H. M. and Lopez González Á, A.},
  journal = {Turk J Med Sci},
  keywords = {grapp-caib},
  number = 4,
  pages = {926-933},
  title = {Determination of cardiovascular risk in 192,711 underweight and normal weight workers},
  type = {Journal Article},
  volume = 52,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN1
  %A Jané, B. A.
  %A Ramírez-Manent, J. I.
  %A Bote, S. A.
  %A Sbert, P. R.
  %A González San Mıguel, H. M.
  %A Lopez González Á, A.
  %D 2022
  %J Turk J Med Sci
  %N 4
  %P 926-933
  %R 10.55730/1300-0144.5392
  %T Determination of cardiovascular risk in 192,711 underweight and normal weight workers
  %V 52
  %X BACKGROUND: The aim of this study was to determine the prevalence of cardiovascular risk factors (CVRF) and the level of cardiovascular risk (CVR), determined with different scales (REGICOR, SCORE, ERICE, vascular age...) in people with low and normal weight. METHODS: A total of 192,711 underweight and normal weight Spanish workers participated. CVR parameters included were weight, abdominal circumference, blood pressure, glycemia (high >125 mg/dL or under hypoglycemic treatment) and lipids (cutoff points: total cholesterol 200 mg/dL, LDL 130 mg/dL, triglycerides 150 mg/dL) were obtained by automated enzymatic methods. Body mass index (BMI) was calculated, considering underweight 18.5 and normal weight 18.5-24.9. A descriptive analysis of the categorical variables was carried out. RESULTS: The values of analytical, anthropometric and clinical parameters were more unfavorable in the normal weight group. Also, the prevalence of alterated values of CVR seen with different scales show higher risk in this group and in all cases the values in men are worse. It was seen that the variable with the greatest influence on the appearance of altered values of the cardiovascular risk scales (CVRS), influencing all of them was the age. DISCUSSION: All the CVRS analyzed showed higher values in the group of people with normal weight compared to those with underweight. Age, followed by sex, were the variables that most influence the appearance of high CVR values.
  

• 
  1.

  Reus X, Sastre ML, Leiva A, Sánchez B, García-Serra C, Ioakeim-Skoufa I, Vicens C. LESS-PHARMA Study: Identifying and Deprescribing Potentially Inappropriate Medication in the Elderly Population with Excessive Polypharmacy in Primary Care. Int J Environ Res Public Health. 2022;19(20).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  Potentially inappropriate medication (PIM) increases adverse drug reactions and mortality, especially in excessively polymedicated patients. General practitioners are often in charge of this process. Some tools have been created to support them in this matter. This study aimed to measure the amount of potentially inappropriate medication among excessively polymedicated patients using several supporting tools and assess the feasibility of these tools in primary care. Several explicit deprescribing criteria were used to identify potentially inappropriate medications. The level of agreement between all the criteria and the acceptance by the general practitioner (GP) was also measured. We analysed whether the drugs proposed for deprescribing were eventually withdrawn after twelve months. The total number of drugs prescribed was 2038. Six hundred and forty-nine drugs (31.8%) were considered potentially inappropriate by at least one of the tools. GPs agreed with the tools in 56.7% of the cases. In a 12-month period, 109 drugs, representing 29.6% of the drugs that GPs agreed to deprescribe, were withdrawn. Elderly excessively polymedicated patients accumulated a great number of PIMs. The use of deprescribing supporting tools, such as explicit criteria, is feasible in primary care, and these tools are well accepted by the GPs. However, eventual withdrawal was carried out in less than half of the cases.

  @article{RN116,
  abstract = {Potentially inappropriate medication (PIM) increases adverse drug reactions and mortality, especially in excessively polymedicated patients. General practitioners are often in charge of this process. Some tools have been created to support them in this matter. This study aimed to measure the amount of potentially inappropriate medication among excessively polymedicated patients using several supporting tools and assess the feasibility of these tools in primary care. Several explicit deprescribing criteria were used to identify potentially inappropriate medications. The level of agreement between all the criteria and the acceptance by the general practitioner (GP) was also measured. We analysed whether the drugs proposed for deprescribing were eventually withdrawn after twelve months. The total number of drugs prescribed was 2038. Six hundred and forty-nine drugs (31.8%) were considered potentially inappropriate by at least one of the tools. GPs agreed with the tools in 56.7% of the cases. In a 12-month period, 109 drugs, representing 29.6% of the drugs that GPs agreed to deprescribe, were withdrawn. Elderly excessively polymedicated patients accumulated a great number of PIMs. The use of deprescribing supporting tools, such as explicit criteria, is feasible in primary care, and these tools are well accepted by the GPs. However, eventual withdrawal was carried out in less than half of the cases.},
  author = {Reus, X. and Sastre, M. L. and Leiva, A. and Sánchez, B. and García-Serra, C. and Ioakeim-Skoufa, I. and Vicens, C.},
  journal = {Int J Environ Res Public Health},
  keywords = {grapp-caib},
  number = 20,
  title = {LESS-PHARMA Study: Identifying and Deprescribing Potentially Inappropriate Medication in the Elderly Population with Excessive Polypharmacy in Primary Care},
  type = {Journal Article},
  volume = 19,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN116
  %A Reus, X.
  %A Sastre, M. L.
  %A Leiva, A.
  %A Sánchez, B.
  %A García-Serra, C.
  %A Ioakeim-Skoufa, I.
  %A Vicens, C.
  %D 2022
  %J Int J Environ Res Public Health
  %N 20
  %R 10.3390/ijerph192013241
  %T LESS-PHARMA Study: Identifying and Deprescribing Potentially Inappropriate Medication in the Elderly Population with Excessive Polypharmacy in Primary Care
  %V 19
  %X Potentially inappropriate medication (PIM) increases adverse drug reactions and mortality, especially in excessively polymedicated patients. General practitioners are often in charge of this process. Some tools have been created to support them in this matter. This study aimed to measure the amount of potentially inappropriate medication among excessively polymedicated patients using several supporting tools and assess the feasibility of these tools in primary care. Several explicit deprescribing criteria were used to identify potentially inappropriate medications. The level of agreement between all the criteria and the acceptance by the general practitioner (GP) was also measured. We analysed whether the drugs proposed for deprescribing were eventually withdrawn after twelve months. The total number of drugs prescribed was 2038. Six hundred and forty-nine drugs (31.8%) were considered potentially inappropriate by at least one of the tools. GPs agreed with the tools in 56.7% of the cases. In a 12-month period, 109 drugs, representing 29.6% of the drugs that GPs agreed to deprescribe, were withdrawn. Elderly excessively polymedicated patients accumulated a great number of PIMs. The use of deprescribing supporting tools, such as explicit criteria, is feasible in primary care, and these tools are well accepted by the GPs. However, eventual withdrawal was carried out in less than half of the cases.
  

• 
  1.

  Recio-Rodriguez JI, Garcia-Ortiz L, Garcia-Yu IA, Lugones-Sanchez C, Olmo EZ, Bolibar B, Casajuana-Closas M, Lopez-Jimenez T, Llobera J, Ramos R, Pombo H, Motrico E, Gil-Girbau M, Lopez-Mendez F, Represas-Carrera F, Maderuelo-Fernandez JA. Effectiveness of a multiple health-behaviour-change intervention in increasing adherence to the Mediterranean Diet in adults (EIRA study): a randomized controlled hybrid trial. BMC Public Health. 2022;22(1):2127.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: The present study describes the effectiveness of a complex intervention that addresses multiple lifestyles to promote healthy behaviours in increasing adherence to the Mediterranean diet (MD).  METHODS: Cluster-randomised, hybrid clinical trial controlled with two parallel groups. The study was carried out in 26 primary Spanish healthcare centres. People aged 45-75 years who presented at least two of the following criteria were included: smoker, low adherence to the MD or insufficient level of physical activity. The intervention group (IG) had three different levels of action: individual, group, and community, with the aim of acting on the behaviours related to smoking, diet and physical activity at the same time. The individual intervention included personalised recommendations and agreements on the objectives to attain. Group sessions were adapted to the context of each healthcare centre. The community intervention was focused on the social prescription of resources and activities performed in the environment of the community of each healthcare centre. Control group (CG) received brief advice given in the usual visits to the doctor's office. The primary outcome was the change, after 12 months, in the number of participants in each group with good adherence to the MD pattern. Secondary outcomes included the change in the total score of the MD adherence score (MEDAS) and the change in some cardiovascular risk factors. RESULTS: Three thousand sixty-two participants were included (IG = 1,481, CG = 1,581). Low adherence to the MD was present in 1,384 (93.5%) participants, of whom 1,233 initiated the intervention and conducted at least one individual visit with a healthcare professional. A greater increase (13.7%; 95% CI, 9.9-17.5; p < 0.001) was obtained by IG in the number of participants who reached 9 points or more (good adherence) in the MEDAS at the final visit. Moreover, the effect attributable to the intervention obtained a greater increase (0.50 points; 95% CI, 0.35 to 0.66; p < 0.001) in IG. CONCLUSIONS: A complex intervention modelled and carried out by primary healthcare professionals, within a real clinical healthcare context, achieved a global increase in the adherence to the MD compared to the brief advice. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03136211. Retrospectively registered on 02/05/2017 https://clinicaltrials.gov/ct2/show/NCT03136211.

  @article{RN36,
  abstract = {BACKGROUND: The present study describes the effectiveness of a complex intervention that addresses multiple lifestyles to promote healthy behaviours in increasing adherence to the Mediterranean diet (MD).  METHODS: Cluster-randomised, hybrid clinical trial controlled with two parallel groups. The study was carried out in 26 primary Spanish healthcare centres. People aged 45-75 years who presented at least two of the following criteria were included: smoker, low adherence to the MD or insufficient level of physical activity. The intervention group (IG) had three different levels of action: individual, group, and community, with the aim of acting on the behaviours related to smoking, diet and physical activity at the same time. The individual intervention included personalised recommendations and agreements on the objectives to attain. Group sessions were adapted to the context of each healthcare centre. The community intervention was focused on the social prescription of resources and activities performed in the environment of the community of each healthcare centre. Control group (CG) received brief advice given in the usual visits to the doctor's office. The primary outcome was the change, after 12 months, in the number of participants in each group with good adherence to the MD pattern. Secondary outcomes included the change in the total score of the MD adherence score (MEDAS) and the change in some cardiovascular risk factors. RESULTS: Three thousand sixty-two participants were included (IG = 1,481, CG = 1,581). Low adherence to the MD was present in 1,384 (93.5%) participants, of whom 1,233 initiated the intervention and conducted at least one individual visit with a healthcare professional. A greater increase (13.7%; 95% CI, 9.9-17.5; p < 0.001) was obtained by IG in the number of participants who reached 9 points or more (good adherence) in the MEDAS at the final visit. Moreover, the effect attributable to the intervention obtained a greater increase (0.50 points; 95% CI, 0.35 to 0.66; p < 0.001) in IG. CONCLUSIONS: A complex intervention modelled and carried out by primary healthcare professionals, within a real clinical healthcare context, achieved a global increase in the adherence to the MD compared to the brief advice. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03136211. Retrospectively registered on 02/05/2017 https://clinicaltrials.gov/ct2/show/NCT03136211.},
  author = {Recio-Rodriguez, J. I. and Garcia-Ortiz, L. and Garcia-Yu, I. A. and Lugones-Sanchez, C. and Olmo, E. Z. and Bolibar, B. and Casajuana-Closas, M. and Lopez-Jimenez, T. and Llobera, J. and Ramos, R. and Pombo, H. and Motrico, E. and Gil-Girbau, M. and Lopez-Mendez, F. and Represas-Carrera, F. and Maderuelo-Fernandez, J. A.},
  journal = {BMC Public Health},
  keywords = {grapp-caib},
  number = 1,
  pages = 2127,
  title = {Effectiveness of a multiple health-behaviour-change intervention in increasing adherence to the Mediterranean Diet in adults (EIRA study): a randomized controlled hybrid trial},
  type = {Journal Article},
  volume = 22,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN36
  %A Recio-Rodriguez, J. I.
  %A Garcia-Ortiz, L.
  %A Garcia-Yu, I. A.
  %A Lugones-Sanchez, C.
  %A Olmo, E. Z.
  %A Bolibar, B.
  %A Casajuana-Closas, M.
  %A Lopez-Jimenez, T.
  %A Llobera, J.
  %A Ramos, R.
  %A Pombo, H.
  %A Motrico, E.
  %A Gil-Girbau, M.
  %A Lopez-Mendez, F.
  %A Represas-Carrera, F.
  %A Maderuelo-Fernandez, J. A.
  %D 2022
  %J BMC Public Health
  %N 1
  %P 2127
  %R 10.1186/s12889-022-14590-y
  %T Effectiveness of a multiple health-behaviour-change intervention in increasing adherence to the Mediterranean Diet in adults (EIRA study): a randomized controlled hybrid trial
  %V 22
  %X BACKGROUND: The present study describes the effectiveness of a complex intervention that addresses multiple lifestyles to promote healthy behaviours in increasing adherence to the Mediterranean diet (MD).  METHODS: Cluster-randomised, hybrid clinical trial controlled with two parallel groups. The study was carried out in 26 primary Spanish healthcare centres. People aged 45-75 years who presented at least two of the following criteria were included: smoker, low adherence to the MD or insufficient level of physical activity. The intervention group (IG) had three different levels of action: individual, group, and community, with the aim of acting on the behaviours related to smoking, diet and physical activity at the same time. The individual intervention included personalised recommendations and agreements on the objectives to attain. Group sessions were adapted to the context of each healthcare centre. The community intervention was focused on the social prescription of resources and activities performed in the environment of the community of each healthcare centre. Control group (CG) received brief advice given in the usual visits to the doctor's office. The primary outcome was the change, after 12 months, in the number of participants in each group with good adherence to the MD pattern. Secondary outcomes included the change in the total score of the MD adherence score (MEDAS) and the change in some cardiovascular risk factors. RESULTS: Three thousand sixty-two participants were included (IG = 1,481, CG = 1,581). Low adherence to the MD was present in 1,384 (93.5%) participants, of whom 1,233 initiated the intervention and conducted at least one individual visit with a healthcare professional. A greater increase (13.7%; 95% CI, 9.9-17.5; p < 0.001) was obtained by IG in the number of participants who reached 9 points or more (good adherence) in the MEDAS at the final visit. Moreover, the effect attributable to the intervention obtained a greater increase (0.50 points; 95% CI, 0.35 to 0.66; p < 0.001) in IG. CONCLUSIONS: A complex intervention modelled and carried out by primary healthcare professionals, within a real clinical healthcare context, achieved a global increase in the adherence to the MD compared to the brief advice. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03136211. Retrospectively registered on 02/05/2017 https://clinicaltrials.gov/ct2/show/NCT03136211.
  

• 
  1.

  Ramírez-Manent JI, Altisench Jané B, Arroyo Bote S, López Roig C, González San Miguel H, López-González AA. Cardiometabolic profile of 15057 elderly Spanish workers: association of sociodemographic variables and tobacco consumption. BMC Geriatr. 2022;22(1):872.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Aging of the world population is one of the most significant demographic changes of our time. Populations older than 60 years are heterogeneous, and age is an independent cardiovascular risk factor aggravated by frailty, obesity, and diabetes, and influenced by several factors, including sex and socioeconomic status. The objective of this study was to calculate cardiovascular risk in workers of both sexes over 60 years of age and to assess whether there are difference s by sex, social class, smoking, and type of job. METHODS: A cross-sectional study was carried out in 15,057 elderly Spanish workers from different autonomous communities in Spain and with different labor occupations. Anthropometric, sociodemographic, clinical, and laboratory values were determined. People were classified according to age from 60 to 64 years inclusive and from 65 to 69 years, smokers and non-smokers, and both blue-collar and white-collar workers. Subsequently, a multivariate analysis was carried out. RESULTS: Men, blue-collar workers, smokers, and aging were factors that influenced cardiovascular risk: with an OR of 3.27 (95% CI: 2.64-4.05) in people 65 years of age or older versus the younger group, and an OR of 3.15 (95% CI: 2.69-3.69) in smokers versus non-smokers. A stronger independent association was found between smoking, age, and cardiovascular risk. The risk of developing non-alcoholic fatty liver and liver fibrosis was much higher in men than in women, with an OR of 4.06 (95% CI: 3.66-4.50) for the former and an OR of 2.10 (95% CI: 1.95-2.26) for the BARD index. CONCLUSIONS: The highest risk groups were observed in male subjects with a history of smoking and blue-collar workers and, as such, should be considered for cardiovascular risk screening programs.

  @article{RN37,
  abstract = {BACKGROUND: Aging of the world population is one of the most significant demographic changes of our time. Populations older than 60 years are heterogeneous, and age is an independent cardiovascular risk factor aggravated by frailty, obesity, and diabetes, and influenced by several factors, including sex and socioeconomic status. The objective of this study was to calculate cardiovascular risk in workers of both sexes over 60 years of age and to assess whether there are difference s by sex, social class, smoking, and type of job. METHODS: A cross-sectional study was carried out in 15,057 elderly Spanish workers from different autonomous communities in Spain and with different labor occupations. Anthropometric, sociodemographic, clinical, and laboratory values were determined. People were classified according to age from 60 to 64 years inclusive and from 65 to 69 years, smokers and non-smokers, and both blue-collar and white-collar workers. Subsequently, a multivariate analysis was carried out. RESULTS: Men, blue-collar workers, smokers, and aging were factors that influenced cardiovascular risk: with an OR of 3.27 (95% CI: 2.64-4.05) in people 65 years of age or older versus the younger group, and an OR of 3.15 (95% CI: 2.69-3.69) in smokers versus non-smokers. A stronger independent association was found between smoking, age, and cardiovascular risk. The risk of developing non-alcoholic fatty liver and liver fibrosis was much higher in men than in women, with an OR of 4.06 (95% CI: 3.66-4.50) for the former and an OR of 2.10 (95% CI: 1.95-2.26) for the BARD index. CONCLUSIONS: The highest risk groups were observed in male subjects with a history of smoking and blue-collar workers and, as such, should be considered for cardiovascular risk screening programs.},
  author = {Ramírez-Manent, J. I. and Altisench Jané, B. and Arroyo Bote, S. and López Roig, C. and González San Miguel, H. and López-González, A. A.},
  journal = {BMC Geriatr},
  keywords = {grapp-caib},
  number = 1,
  pages = 872,
  title = {Cardiometabolic profile of 15057 elderly Spanish workers: association of sociodemographic variables and tobacco consumption},
  type = {Journal Article},
  volume = 22,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN37
  %A Ramírez-Manent, J. I.
  %A Altisench Jané, B.
  %A Arroyo Bote, S.
  %A López Roig, C.
  %A González San Miguel, H.
  %A López-González, A. A.
  %D 2022
  %J BMC Geriatr
  %N 1
  %P 872
  %R 10.1186/s12877-022-03547-w
  %T Cardiometabolic profile of 15057 elderly Spanish workers: association of sociodemographic variables and tobacco consumption
  %V 22
  %X BACKGROUND: Aging of the world population is one of the most significant demographic changes of our time. Populations older than 60 years are heterogeneous, and age is an independent cardiovascular risk factor aggravated by frailty, obesity, and diabetes, and influenced by several factors, including sex and socioeconomic status. The objective of this study was to calculate cardiovascular risk in workers of both sexes over 60 years of age and to assess whether there are difference s by sex, social class, smoking, and type of job. METHODS: A cross-sectional study was carried out in 15,057 elderly Spanish workers from different autonomous communities in Spain and with different labor occupations. Anthropometric, sociodemographic, clinical, and laboratory values were determined. People were classified according to age from 60 to 64 years inclusive and from 65 to 69 years, smokers and non-smokers, and both blue-collar and white-collar workers. Subsequently, a multivariate analysis was carried out. RESULTS: Men, blue-collar workers, smokers, and aging were factors that influenced cardiovascular risk: with an OR of 3.27 (95% CI: 2.64-4.05) in people 65 years of age or older versus the younger group, and an OR of 3.15 (95% CI: 2.69-3.69) in smokers versus non-smokers. A stronger independent association was found between smoking, age, and cardiovascular risk. The risk of developing non-alcoholic fatty liver and liver fibrosis was much higher in men than in women, with an OR of 4.06 (95% CI: 3.66-4.50) for the former and an OR of 2.10 (95% CI: 1.95-2.26) for the BARD index. CONCLUSIONS: The highest risk groups were observed in male subjects with a history of smoking and blue-collar workers and, as such, should be considered for cardiovascular risk screening programs.
  

• 
  1.

  Córdoba García R, Camarelles Guillem F, Muñoz Seco E, Gómez Puente JM, San José Arango J, Ramírez Manent JI, Martín Cantera C, Del Campo Giménez M, Revenga Frauca J, Egea Ronda A, Cervigón Portaencasa R, Rodríguez Benito L. [PAPPS expert group: Lifestyle recommendations]. Aten Primaria. 2022;54 Suppl 1:102442.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  We present the recommendations of the Preventive Activities and Health Promotion Programme (PAPPS) of the semFYC (Spanish Society of Family and Community Medicine) to promote healthy lifestyles using intervention methodology, and preventive actions against tobacco and alcohol use, healthy eating, physical activity in leisure time, prevention of traffic accidents, and child restraint systems. The recommendations have been updated, and new aspects highlighted, such as the definition of low-risk alcohol consumption, and the references have been updated. For the main recommendations, we include specific tables showing the quality of the evidence and the strength of the recommendation.

  @article{RN43,
  abstract = {We present the recommendations of the Preventive Activities and Health Promotion Programme (PAPPS) of the semFYC (Spanish Society of Family and Community Medicine) to promote healthy lifestyles using intervention methodology, and preventive actions against tobacco and alcohol use, healthy eating, physical activity in leisure time, prevention of traffic accidents, and child restraint systems. The recommendations have been updated, and new aspects highlighted, such as the definition of low-risk alcohol consumption, and the references have been updated. For the main recommendations, we include specific tables showing the quality of the evidence and the strength of the recommendation.},
  author = {Córdoba García, R. and Camarelles Guillem, F. and Muñoz Seco, E. and Gómez Puente, J. M. and San José Arango, J. and Ramírez Manent, J. I. and Martín Cantera, C. and Del Campo Giménez, M. and Revenga Frauca, J. and Egea Ronda, A. and Cervigón Portaencasa, R. and Rodríguez Benito, L.},
  journal = {Aten Primaria},
  keywords = {grapp-caib},
  pages = 102442,
  title = {[PAPPS expert group: Lifestyle recommendations]},
  type = {Journal Article},
  volume = {54 Suppl 1},
  year = 2022
  }
  

  %0 Journal Article
  %1 RN43
  %A Córdoba García, R.
  %A Camarelles Guillem, F.
  %A Muñoz Seco, E.
  %A Gómez Puente, J. M.
  %A San José Arango, J.
  %A Ramírez Manent, J. I.
  %A Martín Cantera, C.
  %A Del Campo Giménez, M.
  %A Revenga Frauca, J.
  %A Egea Ronda, A.
  %A Cervigón Portaencasa, R.
  %A Rodríguez Benito, L.
  %D 2022
  %J Aten Primaria
  %P 102442
  %R 10.1016/j.aprim.2022.102442
  %T [PAPPS expert group: Lifestyle recommendations]
  %V 54 Suppl 1
  %X We present the recommendations of the Preventive Activities and Health Promotion Programme (PAPPS) of the semFYC (Spanish Society of Family and Community Medicine) to promote healthy lifestyles using intervention methodology, and preventive actions against tobacco and alcohol use, healthy eating, physical activity in leisure time, prevention of traffic accidents, and child restraint systems. The recommendations have been updated, and new aspects highlighted, such as the definition of low-risk alcohol consumption, and the references have been updated. For the main recommendations, we include specific tables showing the quality of the evidence and the strength of the recommendation.
  

• 
  1.

  Galmes-Panades AM, Angullo E, Mira-Martínez S, Bennasar-Veny M, Zamanillo-Campos R, Gómez-Juanes R, Konieczna J, Jiménez R, Serrano-Ripoll MJ, Fiol deRoque MA, Miralles J, Yañez AM, Romaguera D, Vidal-Thomas MC, Llobera-Canaves J, García-Toro M, Vicens C, Gervilla-García E, Oña JI, Malih N, Leiva A, Bulilete O, Montaño JJ, Gili M, Roca M, Ricci-Cabello I. Development and Evaluation of a Digital Health Intervention to Prevent Type 2 Diabetes in Primary Care: The PREDIABETEXT Study Protocol for a Randomised Clinical Trial. Int J Environ Res Public Health. 2022;19(22).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease associated with an increased risk of comorbidities, premature death, and health costs. Prediabetes is a stage of glucose alteration previous to T2DM, that can be reversed. The aim of the study is to develop and evaluate a low-intensity, multifaceted, digital intervention to prevent T2DM. The intervention comprises: (1) the use of mobile health technology to send tailored text messages promoting lifestyle changes to people at risk of T2DM and (2) the provision of online education to primary healthcare physicians and nurses about management of prediabetes. METHODS: In stages 1-4 we will design, develop and pilot-test the intervention. In Stage 5 we will conduct a phase II, six-month, three-arm, cluster randomized, clinical trial with 42 primary care professionals and 420 patients at risk of T2DM. Patients will be allocated to a control group (usual care), intervention A (patient messaging intervention), or intervention B (patient messaging intervention plus online education to their primary healthcare professionals). The primary outcome will be glycated haemoglobin. All the procedures obtained ethical approval in June 2021 (CEI-IB Ref No: IB4495/21PI). DISCUSSION: Digital health interventions can effectively prevent T2DM and reduce important T2DM risk factors such as overweight or hypertension. In Spain, this type of intervention is understudied. Moreover, there is controversy regarding the type of digital health interventions that are more effective. Findings from this study may contribute to address T2DM prevention, through a low-cost and easily implementable intervention.

  @article{RN41,
  abstract = {BACKGROUND: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease associated with an increased risk of comorbidities, premature death, and health costs. Prediabetes is a stage of glucose alteration previous to T2DM, that can be reversed. The aim of the study is to develop and evaluate a low-intensity, multifaceted, digital intervention to prevent T2DM. The intervention comprises: (1) the use of mobile health technology to send tailored text messages promoting lifestyle changes to people at risk of T2DM and (2) the provision of online education to primary healthcare physicians and nurses about management of prediabetes. METHODS: In stages 1-4 we will design, develop and pilot-test the intervention. In Stage 5 we will conduct a phase II, six-month, three-arm, cluster randomized, clinical trial with 42 primary care professionals and 420 patients at risk of T2DM. Patients will be allocated to a control group (usual care), intervention A (patient messaging intervention), or intervention B (patient messaging intervention plus online education to their primary healthcare professionals). The primary outcome will be glycated haemoglobin. All the procedures obtained ethical approval in June 2021 (CEI-IB Ref No: IB4495/21PI). DISCUSSION: Digital health interventions can effectively prevent T2DM and reduce important T2DM risk factors such as overweight or hypertension. In Spain, this type of intervention is understudied. Moreover, there is controversy regarding the type of digital health interventions that are more effective. Findings from this study may contribute to address T2DM prevention, through a low-cost and easily implementable intervention.},
  author = {Galmes-Panades, A. M. and Angullo, E. and Mira-Martínez, S. and Bennasar-Veny, M. and Zamanillo-Campos, R. and Gómez-Juanes, R. and Konieczna, J. and Jiménez, R. and Serrano-Ripoll, M. J. and Fiol deRoque, M. A. and Miralles, J. and Yañez, A. M. and Romaguera, D. and Vidal-Thomas, M. C. and Llobera-Canaves, J. and García-Toro, M. and Vicens, C. and Gervilla-García, E. and Oña, J. I. and Malih, N. and Leiva, A. and Bulilete, O. and Montaño, J. J. and Gili, M. and Roca, M. and Ricci-Cabello, I.},
  journal = {Int J Environ Res Public Health},
  keywords = {grapp-caib},
  number = 22,
  title = {Development and Evaluation of a Digital Health Intervention to Prevent Type 2 Diabetes in Primary Care: The PREDIABETEXT Study Protocol for a Randomised Clinical Trial},
  type = {Journal Article},
  volume = 19,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN41
  %A Galmes-Panades, A. M.
  %A Angullo, E.
  %A Mira-Martínez, S.
  %A Bennasar-Veny, M.
  %A Zamanillo-Campos, R.
  %A Gómez-Juanes, R.
  %A Konieczna, J.
  %A Jiménez, R.
  %A Serrano-Ripoll, M. J.
  %A Fiol deRoque, M. A.
  %A Miralles, J.
  %A Yañez, A. M.
  %A Romaguera, D.
  %A Vidal-Thomas, M. C.
  %A Llobera-Canaves, J.
  %A García-Toro, M.
  %A Vicens, C.
  %A Gervilla-García, E.
  %A Oña, J. I.
  %A Malih, N.
  %A Leiva, A.
  %A Bulilete, O.
  %A Montaño, J. J.
  %A Gili, M.
  %A Roca, M.
  %A Ricci-Cabello, I.
  %D 2022
  %J Int J Environ Res Public Health
  %N 22
  %R 10.3390/ijerph192214706
  %T Development and Evaluation of a Digital Health Intervention to Prevent Type 2 Diabetes in Primary Care: The PREDIABETEXT Study Protocol for a Randomised Clinical Trial
  %V 19
  %X BACKGROUND: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease associated with an increased risk of comorbidities, premature death, and health costs. Prediabetes is a stage of glucose alteration previous to T2DM, that can be reversed. The aim of the study is to develop and evaluate a low-intensity, multifaceted, digital intervention to prevent T2DM. The intervention comprises: (1) the use of mobile health technology to send tailored text messages promoting lifestyle changes to people at risk of T2DM and (2) the provision of online education to primary healthcare physicians and nurses about management of prediabetes. METHODS: In stages 1-4 we will design, develop and pilot-test the intervention. In Stage 5 we will conduct a phase II, six-month, three-arm, cluster randomized, clinical trial with 42 primary care professionals and 420 patients at risk of T2DM. Patients will be allocated to a control group (usual care), intervention A (patient messaging intervention), or intervention B (patient messaging intervention plus online education to their primary healthcare professionals). The primary outcome will be glycated haemoglobin. All the procedures obtained ethical approval in June 2021 (CEI-IB Ref No: IB4495/21PI). DISCUSSION: Digital health interventions can effectively prevent T2DM and reduce important T2DM risk factors such as overweight or hypertension. In Spain, this type of intervention is understudied. Moreover, there is controversy regarding the type of digital health interventions that are more effective. Findings from this study may contribute to address T2DM prevention, through a low-cost and easily implementable intervention.
  

• 
  1.

  Gómez-Sánchez L, Gómez-Sánchez M, Lugones-Sánchez C, Rodríguez-Sánchez E, Tamayo-Morales O, Gonzalez-Sánchez S, Magallón-Botaya R, Ramirez-Manent JI, Recio-Rodriguez JI, Agudo-Conde C, García-Ortiz L, Gómez-Marcos MA. Long-Term Effectiveness of a Smartphone App and a Smart Band on Arterial Stiffness and Central Hemodynamic Parameters in a Population with Overweight and Obesity (Evident 3 Study): Randomised Controlled Trial. Nutrients. 2022;14(22).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: mHealth technologies could help to improve cardiovascular health; however, their effect on arterial stiffness and hemodynamic parameters has not been explored to date. OBJECTIVE: To evaluate the effect of a mHealth intervention, at 3 and 12 months, on arterial stiffness and central hemodynamic parameters in a sedentary population with overweight and obesity. METHODS: Randomised controlled clinical trial (Evident 3 study). 253 subjects were included: 127 in the intervention group (IG) and 126 in the control group (CG). The IG subjects were briefed on the use of the Evident 3 app and a smart band (Mi Band 2, Xiaomi) for 3 months to promote healthy lifestyles. All measurements were recorded in the baseline visit and at 3 and 12 months. The carotid-femoral pulse wave velocity (cfPWV) and the central hemodynamic parameters were measured using a SphigmoCor System(®) device, whereas the brachial-ankle pulse wave velocity (baPWV) and the Cardio Ankle Vascular Index (CAVI) were measured using a VaSera VS-2000(®) device. RESULTS: Of the 253 subjects who attended the initial visit, 237 (93.7%) completed the visit at 3 months of the intervention, and 217 (85.3%) completed the visit at 12 months of the intervention. At 12 months, IG showed a decrease in peripheral augmentation index (PAIx) (-3.60; 95% CI -7.22 to -0.00) and ejection duration (ED) (-0.82; 95% CI -1.36 to -0.27), and an increase in subendocardial viability ratio (SEVR) (5.31; 95% CI 1.18 to 9.44). In CG, cfPWV decreased at 3 months (-0.28 m/s; 95% CI -0.54 to -0.02) and at 12 months (-0.30 m/s, 95% CI -0.54 to -0.05), central diastolic pressure (cDBP) decreased at 12 months (-1.64 mm/Hg; 95% CI -3.19 to -0.10). When comparing the groups we found no differences between any variables analyzed. CONCLUSIONS: In sedentary adults with overweight or obesity, the multicomponent intervention (Smartphone app and an activity-tracking band) for 3 months did not modify arterial stiffness or the central hemodynamic parameters, with respect to the control group. However, at 12 months, CG presented a decrease of cfPWV and cDBP, whereas IG showed a decrease of PAIx and ED and an increase of SEVR.

  @article{RN42,
  abstract = {BACKGROUND: mHealth technologies could help to improve cardiovascular health; however, their effect on arterial stiffness and hemodynamic parameters has not been explored to date. OBJECTIVE: To evaluate the effect of a mHealth intervention, at 3 and 12 months, on arterial stiffness and central hemodynamic parameters in a sedentary population with overweight and obesity. METHODS: Randomised controlled clinical trial (Evident 3 study). 253 subjects were included: 127 in the intervention group (IG) and 126 in the control group (CG). The IG subjects were briefed on the use of the Evident 3 app and a smart band (Mi Band 2, Xiaomi) for 3 months to promote healthy lifestyles. All measurements were recorded in the baseline visit and at 3 and 12 months. The carotid-femoral pulse wave velocity (cfPWV) and the central hemodynamic parameters were measured using a SphigmoCor System(®) device, whereas the brachial-ankle pulse wave velocity (baPWV) and the Cardio Ankle Vascular Index (CAVI) were measured using a VaSera VS-2000(®) device. RESULTS: Of the 253 subjects who attended the initial visit, 237 (93.7%) completed the visit at 3 months of the intervention, and 217 (85.3%) completed the visit at 12 months of the intervention. At 12 months, IG showed a decrease in peripheral augmentation index (PAIx) (-3.60; 95% CI -7.22 to -0.00) and ejection duration (ED) (-0.82; 95% CI -1.36 to -0.27), and an increase in subendocardial viability ratio (SEVR) (5.31; 95% CI 1.18 to 9.44). In CG, cfPWV decreased at 3 months (-0.28 m/s; 95% CI -0.54 to -0.02) and at 12 months (-0.30 m/s, 95% CI -0.54 to -0.05), central diastolic pressure (cDBP) decreased at 12 months (-1.64 mm/Hg; 95% CI -3.19 to -0.10). When comparing the groups we found no differences between any variables analyzed. CONCLUSIONS: In sedentary adults with overweight or obesity, the multicomponent intervention (Smartphone app and an activity-tracking band) for 3 months did not modify arterial stiffness or the central hemodynamic parameters, with respect to the control group. However, at 12 months, CG presented a decrease of cfPWV and cDBP, whereas IG showed a decrease of PAIx and ED and an increase of SEVR.},
  author = {Gómez-Sánchez, L. and Gómez-Sánchez, M. and Lugones-Sánchez, C. and Rodríguez-Sánchez, E. and Tamayo-Morales, O. and Gonzalez-Sánchez, S. and Magallón-Botaya, R. and Ramirez-Manent, J. I. and Recio-Rodriguez, J. I. and Agudo-Conde, C. and García-Ortiz, L. and Gómez-Marcos, M. A.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  number = 22,
  title = {Long-Term Effectiveness of a Smartphone App and a Smart Band on Arterial Stiffness and Central Hemodynamic Parameters in a Population with Overweight and Obesity (Evident 3 Study): Randomised Controlled Trial},
  type = {Journal Article},
  volume = 14,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN42
  %A Gómez-Sánchez, L.
  %A Gómez-Sánchez, M.
  %A Lugones-Sánchez, C.
  %A Rodríguez-Sánchez, E.
  %A Tamayo-Morales, O.
  %A Gonzalez-Sánchez, S.
  %A Magallón-Botaya, R.
  %A Ramirez-Manent, J. I.
  %A Recio-Rodriguez, J. I.
  %A Agudo-Conde, C.
  %A García-Ortiz, L.
  %A Gómez-Marcos, M. A.
  %D 2022
  %J Nutrients
  %N 22
  %R 10.3390/nu14224758
  %T Long-Term Effectiveness of a Smartphone App and a Smart Band on Arterial Stiffness and Central Hemodynamic Parameters in a Population with Overweight and Obesity (Evident 3 Study): Randomised Controlled Trial
  %V 14
  %X BACKGROUND: mHealth technologies could help to improve cardiovascular health; however, their effect on arterial stiffness and hemodynamic parameters has not been explored to date. OBJECTIVE: To evaluate the effect of a mHealth intervention, at 3 and 12 months, on arterial stiffness and central hemodynamic parameters in a sedentary population with overweight and obesity. METHODS: Randomised controlled clinical trial (Evident 3 study). 253 subjects were included: 127 in the intervention group (IG) and 126 in the control group (CG). The IG subjects were briefed on the use of the Evident 3 app and a smart band (Mi Band 2, Xiaomi) for 3 months to promote healthy lifestyles. All measurements were recorded in the baseline visit and at 3 and 12 months. The carotid-femoral pulse wave velocity (cfPWV) and the central hemodynamic parameters were measured using a SphigmoCor System(®) device, whereas the brachial-ankle pulse wave velocity (baPWV) and the Cardio Ankle Vascular Index (CAVI) were measured using a VaSera VS-2000(®) device. RESULTS: Of the 253 subjects who attended the initial visit, 237 (93.7%) completed the visit at 3 months of the intervention, and 217 (85.3%) completed the visit at 12 months of the intervention. At 12 months, IG showed a decrease in peripheral augmentation index (PAIx) (-3.60; 95% CI -7.22 to -0.00) and ejection duration (ED) (-0.82; 95% CI -1.36 to -0.27), and an increase in subendocardial viability ratio (SEVR) (5.31; 95% CI 1.18 to 9.44). In CG, cfPWV decreased at 3 months (-0.28 m/s; 95% CI -0.54 to -0.02) and at 12 months (-0.30 m/s, 95% CI -0.54 to -0.05), central diastolic pressure (cDBP) decreased at 12 months (-1.64 mm/Hg; 95% CI -3.19 to -0.10). When comparing the groups we found no differences between any variables analyzed. CONCLUSIONS: In sedentary adults with overweight or obesity, the multicomponent intervention (Smartphone app and an activity-tracking band) for 3 months did not modify arterial stiffness or the central hemodynamic parameters, with respect to the control group. However, at 12 months, CG presented a decrease of cfPWV and cDBP, whereas IG showed a decrease of PAIx and ED and an increase of SEVR.
  

• 
  1.

  Chela-Alvarez X, Bulilete O, Garcia-Illan E, Vidal-Thomàs M, Llobera J. Hotel housekeepers and occupational health: experiences and perceived risks. Ann Occup Environ Med. 2022;34:e29.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Hotel housekeepers are one of the most important occupational group within tourism hotel sector; various health problems related to their job have been described, above all musculoskeletal disorders. The objective of this study is to understand the experiences and perceptions of hotel housekeepers and key informants from the Balearic Islands (Spain) regarding occupational health conditions and the strategies employed to mitigate them. METHODS: A qualitative study was carried out. Six focus groups with hotel housekeepers and 10 semi-structured interviews with key informants were conducted. Next, we carried out a content analysis. RESULTS: Hotel housekeepers reported musculoskeletal disorders, anxiety and stress as main occupational health problems; health professionals underscored the physical problems. Hotel housekeepers perceived that their work (physically demanding and with repetitive movements) caused their health conditions. To solve health issues, they used medication (anti-inflammatory agents, painkillers, sedatives and anxiolytics), which allowed them to continue working; health public services, generally rated as satisfactory; individual protective equipment; ergonomics (with difficulties due to high work pace and hotel facilities) and physical activity. Two contrasting attitudes were identified regarding sick leave: HHs who refused to accept a doctor-prescribed sick leave (due to fear of being fired, sense of responsibility, ...), and those who accepted it (because they could not continue working, they prioritised health before work). CONCLUSIONS: Our results might contribute to plan improvement strategies and programs to address health problems among hotel housekeepers. These programs should include interventions, such as coping strategies for the work-related risk factors (i.e., stress) and strategies to reduce medicine consumption. Additionally, hotel facilities should adopt policies focused on making workplaces more ergonomic (i.e., furniture) and to diminish the work pace.

  @article{RN121,
  abstract = {BACKGROUND: Hotel housekeepers are one of the most important occupational group within tourism hotel sector; various health problems related to their job have been described, above all musculoskeletal disorders. The objective of this study is to understand the experiences and perceptions of hotel housekeepers and key informants from the Balearic Islands (Spain) regarding occupational health conditions and the strategies employed to mitigate them. METHODS: A qualitative study was carried out. Six focus groups with hotel housekeepers and 10 semi-structured interviews with key informants were conducted. Next, we carried out a content analysis. RESULTS: Hotel housekeepers reported musculoskeletal disorders, anxiety and stress as main occupational health problems; health professionals underscored the physical problems. Hotel housekeepers perceived that their work (physically demanding and with repetitive movements) caused their health conditions. To solve health issues, they used medication (anti-inflammatory agents, painkillers, sedatives and anxiolytics), which allowed them to continue working; health public services, generally rated as satisfactory; individual protective equipment; ergonomics (with difficulties due to high work pace and hotel facilities) and physical activity. Two contrasting attitudes were identified regarding sick leave: HHs who refused to accept a doctor-prescribed sick leave (due to fear of being fired, sense of responsibility, ...), and those who accepted it (because they could not continue working, they prioritised health before work). CONCLUSIONS: Our results might contribute to plan improvement strategies and programs to address health problems among hotel housekeepers. These programs should include interventions, such as coping strategies for the work-related risk factors (i.e., stress) and strategies to reduce medicine consumption. Additionally, hotel facilities should adopt policies focused on making workplaces more ergonomic (i.e., furniture) and to diminish the work pace.},
  author = {Chela-Alvarez, X. and Bulilete, O. and Garcia-Illan, E. and Vidal-Thomàs, M. and Llobera, J.},
  journal = {Ann Occup Environ Med},
  keywords = {grapp-caib},
  pages = {e29},
  title = {Hotel housekeepers and occupational health: experiences and perceived risks},
  type = {Journal Article},
  volume = 34,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN121
  %A Chela-Alvarez, X.
  %A Bulilete, O.
  %A Garcia-Illan, E.
  %A Vidal-Thomàs, M.
  %A Llobera, J.
  %D 2022
  %J Ann Occup Environ Med
  %P e29
  %R 10.35371/aoem.2022.34.e29
  %T Hotel housekeepers and occupational health: experiences and perceived risks
  %V 34
  %X BACKGROUND: Hotel housekeepers are one of the most important occupational group within tourism hotel sector; various health problems related to their job have been described, above all musculoskeletal disorders. The objective of this study is to understand the experiences and perceptions of hotel housekeepers and key informants from the Balearic Islands (Spain) regarding occupational health conditions and the strategies employed to mitigate them. METHODS: A qualitative study was carried out. Six focus groups with hotel housekeepers and 10 semi-structured interviews with key informants were conducted. Next, we carried out a content analysis. RESULTS: Hotel housekeepers reported musculoskeletal disorders, anxiety and stress as main occupational health problems; health professionals underscored the physical problems. Hotel housekeepers perceived that their work (physically demanding and with repetitive movements) caused their health conditions. To solve health issues, they used medication (anti-inflammatory agents, painkillers, sedatives and anxiolytics), which allowed them to continue working; health public services, generally rated as satisfactory; individual protective equipment; ergonomics (with difficulties due to high work pace and hotel facilities) and physical activity. Two contrasting attitudes were identified regarding sick leave: HHs who refused to accept a doctor-prescribed sick leave (due to fear of being fired, sense of responsibility, ...), and those who accepted it (because they could not continue working, they prioritised health before work). CONCLUSIONS: Our results might contribute to plan improvement strategies and programs to address health problems among hotel housekeepers. These programs should include interventions, such as coping strategies for the work-related risk factors (i.e., stress) and strategies to reduce medicine consumption. Additionally, hotel facilities should adopt policies focused on making workplaces more ergonomic (i.e., furniture) and to diminish the work pace.
  

• 
  1.

  Garcia A, Yáñez AM, Bennasar-Veny M, Navarro C, Salva J, Ibarra O, Gomez-Juanes R, Serrano-Ripoll MJ, Oliván B, Gili M, Roca M, Riera-Serra P, Aguilar-Latorre A, Montero-Marin J, Garcia-Toro M. Efficacy of an adjuvant non-face-to-face multimodal lifestyle modification program for patients with treatment-resistant major depression: A randomized controlled trial. Psychiatry Res. 2022;319:114975.

  AbstractBibTeXEndNoteDOIBibSonomy

  BACKGROUND: The high prevalence of depression is partly attributable to the poor response of patients to first-line antidepressants. Multimodal programs that promote a healthy lifestyle are successful in treating depression when used as a complementary therapy, but their medium- and long-term benefits have not been demonstrated for patients with treatment-resistant depression (TRD). The main aim of this study was to compare the effectiveness of a lifestyle modification program (LMP) with mindfulness-based cognitive therapy (MBCT) and a placebo-control (written suggestions for lifestyle changes) in Spanish patients with TRD. METHODS: This controlled clinical trial randomized 94 patients with TRD into 3 arms. The primary outcome was the Beck Depression Inventory-II (BDI-II) score at baseline, 2, 6 and 12 months. The secondary outcomes were changes in scores that evaluated quality-of-life, adherence to the Mediterranean diet, physical activity, and social support. RESULTS: Relative to the placebo group, the LMP and MBCT groups had significantly better quality of life (p = 0.017; p = 0.027), and the LMP group had significantly better adherence to the Mediterranean diet (p<0.001) and reduced use of antidepressants (p = 0.036). However, the three groups showed no significant differences in BDI-II score. LIMITATIONS: Only about half of the planned 180 patients were recruited, in part due to the COVID-19 pandemic. CONCLUSIONS: There was no evidence that the LMP treatment significantly reduced symptoms of depression relative to the other groups during the COVID-19 lockdown.

  @article{RN122,
  abstract = {BACKGROUND: The high prevalence of depression is partly attributable to the poor response of patients to first-line antidepressants. Multimodal programs that promote a healthy lifestyle are successful in treating depression when used as a complementary therapy, but their medium- and long-term benefits have not been demonstrated for patients with treatment-resistant depression (TRD). The main aim of this study was to compare the effectiveness of a lifestyle modification program (LMP) with mindfulness-based cognitive therapy (MBCT) and a placebo-control (written suggestions for lifestyle changes) in Spanish patients with TRD. METHODS: This controlled clinical trial randomized 94 patients with TRD into 3 arms. The primary outcome was the Beck Depression Inventory-II (BDI-II) score at baseline, 2, 6 and 12 months. The secondary outcomes were changes in scores that evaluated quality-of-life, adherence to the Mediterranean diet, physical activity, and social support. RESULTS: Relative to the placebo group, the LMP and MBCT groups had significantly better quality of life (p = 0.017; p = 0.027), and the LMP group had significantly better adherence to the Mediterranean diet (p<0.001) and reduced use of antidepressants (p = 0.036). However, the three groups showed no significant differences in BDI-II score. LIMITATIONS: Only about half of the planned 180 patients were recruited, in part due to the COVID-19 pandemic. CONCLUSIONS: There was no evidence that the LMP treatment significantly reduced symptoms of depression relative to the other groups during the COVID-19 lockdown.},
  author = {Garcia, A. and Yáñez, A. M. and Bennasar-Veny, M. and Navarro, C. and Salva, J. and Ibarra, O. and Gomez-Juanes, R. and Serrano-Ripoll, M. J. and Oliván, B. and Gili, M. and Roca, M. and Riera-Serra, P. and Aguilar-Latorre, A. and Montero-Marin, J. and Garcia-Toro, M.},
  journal = {Psychiatry Res},
  keywords = {grapp-caib},
  pages = 114975,
  title = {Efficacy of an adjuvant non-face-to-face multimodal lifestyle modification program for patients with treatment-resistant major depression: A randomized controlled trial},
  type = {Journal Article},
  volume = 319,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN122
  %A Garcia, A.
  %A Yáñez, A. M.
  %A Bennasar-Veny, M.
  %A Navarro, C.
  %A Salva, J.
  %A Ibarra, O.
  %A Gomez-Juanes, R.
  %A Serrano-Ripoll, M. J.
  %A Oliván, B.
  %A Gili, M.
  %A Roca, M.
  %A Riera-Serra, P.
  %A Aguilar-Latorre, A.
  %A Montero-Marin, J.
  %A Garcia-Toro, M.
  %D 2022
  %J Psychiatry Res
  %P 114975
  %R 10.1016/j.psychres.2022.114975
  %T Efficacy of an adjuvant non-face-to-face multimodal lifestyle modification program for patients with treatment-resistant major depression: A randomized controlled trial
  %V 319
  %X BACKGROUND: The high prevalence of depression is partly attributable to the poor response of patients to first-line antidepressants. Multimodal programs that promote a healthy lifestyle are successful in treating depression when used as a complementary therapy, but their medium- and long-term benefits have not been demonstrated for patients with treatment-resistant depression (TRD). The main aim of this study was to compare the effectiveness of a lifestyle modification program (LMP) with mindfulness-based cognitive therapy (MBCT) and a placebo-control (written suggestions for lifestyle changes) in Spanish patients with TRD. METHODS: This controlled clinical trial randomized 94 patients with TRD into 3 arms. The primary outcome was the Beck Depression Inventory-II (BDI-II) score at baseline, 2, 6 and 12 months. The secondary outcomes were changes in scores that evaluated quality-of-life, adherence to the Mediterranean diet, physical activity, and social support. RESULTS: Relative to the placebo group, the LMP and MBCT groups had significantly better quality of life (p = 0.017; p = 0.027), and the LMP group had significantly better adherence to the Mediterranean diet (p<0.001) and reduced use of antidepressants (p = 0.036). However, the three groups showed no significant differences in BDI-II score. LIMITATIONS: Only about half of the planned 180 patients were recruited, in part due to the COVID-19 pandemic. CONCLUSIONS: There was no evidence that the LMP treatment significantly reduced symptoms of depression relative to the other groups during the COVID-19 lockdown.
  

• 
  1.

  Ramírez-Manent JI, Martínez-Almoyna E, López C, Busquets-Cortés C, González San Miguel H, López-González Á A. Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers. Metabolites. 2022;12(11).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  Insulin resistance (IR) has been identified as a key factor in the appearance of non-alcoholic fatty liver disease (NAFLD) as it is related through a complex molecular biochemical and immunological mechanism. Our aim was to evaluate the relationship between different scales that estimate the risk of IR and scales that determine the risk of NAFLD. This descriptive and cross-sectional study was performed in 219,477 Spanish workers from different sectors and Spanish regions. The prevalence of high values of all the IR scales increases as the values of the NAFLD and liver fibrosis scales increase. In the multivariate analysis, the risk of presenting high values in the IR scales increases greatly as the values of the NAFLD and hepatic fibrosis scales increase, with particularly high OR values when using the Metabolic Score for Insulin Resistance (METS-IR) scale (LAP high OR 42.20 (95% CI (39.10-45.56) and FLI high OR 32.35 (95% CI 31.10-33.61)). We can conclude that there is a direct relationship between the values of the IR scales and the NAFLD and liver fibrosis scales in our population.

  @article{RN2,
  abstract = {Insulin resistance (IR) has been identified as a key factor in the appearance of non-alcoholic fatty liver disease (NAFLD) as it is related through a complex molecular biochemical and immunological mechanism. Our aim was to evaluate the relationship between different scales that estimate the risk of IR and scales that determine the risk of NAFLD. This descriptive and cross-sectional study was performed in 219,477 Spanish workers from different sectors and Spanish regions. The prevalence of high values of all the IR scales increases as the values of the NAFLD and liver fibrosis scales increase. In the multivariate analysis, the risk of presenting high values in the IR scales increases greatly as the values of the NAFLD and hepatic fibrosis scales increase, with particularly high OR values when using the Metabolic Score for Insulin Resistance (METS-IR) scale (LAP high OR 42.20 (95% CI (39.10-45.56) and FLI high OR 32.35 (95% CI 31.10-33.61)). We can conclude that there is a direct relationship between the values of the IR scales and the NAFLD and liver fibrosis scales in our population.},
  author = {Ramírez-Manent, J. I. and Martínez-Almoyna, E. and López, C. and Busquets-Cortés, C. and González San Miguel, H. and López-González Á, A.},
  journal = {Metabolites},
  keywords = {grapp-caib},
  number = 11,
  title = {Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers},
  type = {Journal Article},
  volume = 12,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN2
  %A Ramírez-Manent, J. I.
  %A Martínez-Almoyna, E.
  %A López, C.
  %A Busquets-Cortés, C.
  %A González San Miguel, H.
  %A López-González Á, A.
  %D 2022
  %J Metabolites
  %N 11
  %R 10.3390/metabo12111093
  %T Relationship between Insulin Resistance Risk Scales and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Scales in 219,477 Spanish Workers
  %V 12
  %X Insulin resistance (IR) has been identified as a key factor in the appearance of non-alcoholic fatty liver disease (NAFLD) as it is related through a complex molecular biochemical and immunological mechanism. Our aim was to evaluate the relationship between different scales that estimate the risk of IR and scales that determine the risk of NAFLD. This descriptive and cross-sectional study was performed in 219,477 Spanish workers from different sectors and Spanish regions. The prevalence of high values of all the IR scales increases as the values of the NAFLD and liver fibrosis scales increase. In the multivariate analysis, the risk of presenting high values in the IR scales increases greatly as the values of the NAFLD and hepatic fibrosis scales increase, with particularly high OR values when using the Metabolic Score for Insulin Resistance (METS-IR) scale (LAP high OR 42.20 (95% CI (39.10-45.56) and FLI high OR 32.35 (95% CI 31.10-33.61)). We can conclude that there is a direct relationship between the values of the IR scales and the NAFLD and liver fibrosis scales in our population.
  

• 
  1.

  Busquets-Cortés C, López C, Paublini H, Arroyo Bote S, López-González Á A, Ramírez-Manent JI. Relationship between Atherogenic Dyslipidaemia and Lipid Triad with Different Scales of Overweight and Obesity in 418,343 Spanish Workers. J Nutr Metab. 2022;2022:9946255.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  Obesity induces alterations in lipid biochemistry, evolving toward dyslipidaemia atherogenesis, a critical factor in the development of cardiovascular events. Two relevant forms of lipid abnormalities are atherogenic dyslipidaemia (AD) and lipid triad (LT), which involve alterations in triglyceride levels, HDL-c, and LDL-c. The aim of this study was to assess the linkage of atherogenic AD and LT with different scales of overweight and obesity. We carried out a cross-sectional study including 418,343 Spanish adult workers, recruited from workplace health assessments. Atherogenic dyslipidaemia was defined as triglyceride levels ≥ 150 mg/dL, HDL values < 40 mg/dL in men and <45 mg/dL in women, and normal LDL. Additionally, if LDL levels were >160 mg/dL, LT was considered. Subjects affected by AD and LT in the study exhibited significantly higher mean values than those without AD and LT in all overweight, obesity, and body fat related scales studied. VAI (visceral adiposity index) was the strongest predictor of AD (AUC = 0.934, 95% CI: 0.933 to 0.936) and LT (AUC = 0.926, 95% CI: 0.923 to 0.928). Atherogenic dyslipidaemia and LT positively correlate with different scales of overweight and obesity. Further studies should aim to identify other contributory factors. Our obtained data might be useful in laying the groundwork for future works on AD and LT.

  @article{RN98,
  abstract = {Obesity induces alterations in lipid biochemistry, evolving toward dyslipidaemia atherogenesis, a critical factor in the development of cardiovascular events. Two relevant forms of lipid abnormalities are atherogenic dyslipidaemia (AD) and lipid triad (LT), which involve alterations in triglyceride levels, HDL-c, and LDL-c. The aim of this study was to assess the linkage of atherogenic AD and LT with different scales of overweight and obesity. We carried out a cross-sectional study including 418,343 Spanish adult workers, recruited from workplace health assessments. Atherogenic dyslipidaemia was defined as triglyceride levels ≥ 150 mg/dL, HDL values < 40 mg/dL in men and <45 mg/dL in women, and normal LDL. Additionally, if LDL levels were >160 mg/dL, LT was considered. Subjects affected by AD and LT in the study exhibited significantly higher mean values than those without AD and LT in all overweight, obesity, and body fat related scales studied. VAI (visceral adiposity index) was the strongest predictor of AD (AUC = 0.934, 95% CI: 0.933 to 0.936) and LT (AUC = 0.926, 95% CI: 0.923 to 0.928). Atherogenic dyslipidaemia and LT positively correlate with different scales of overweight and obesity. Further studies should aim to identify other contributory factors. Our obtained data might be useful in laying the groundwork for future works on AD and LT.},
  author = {Busquets-Cortés, C. and López, C. and Paublini, H. and Arroyo Bote, S. and López-González Á, A. and Ramírez-Manent, J. I.},
  journal = {J Nutr Metab},
  keywords = {grapp-caib},
  pages = 9946255,
  title = {Relationship between Atherogenic Dyslipidaemia and Lipid Triad with Different Scales of Overweight and Obesity in 418,343 Spanish Workers},
  type = {Journal Article},
  volume = 2022,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN98
  %A Busquets-Cortés, C.
  %A López, C.
  %A Paublini, H.
  %A Arroyo Bote, S.
  %A López-González Á, A.
  %A Ramírez-Manent, J. I.
  %D 2022
  %J J Nutr Metab
  %P 9946255
  %R 10.1155/2022/9946255
  %T Relationship between Atherogenic Dyslipidaemia and Lipid Triad with Different Scales of Overweight and Obesity in 418,343 Spanish Workers
  %V 2022
  %X Obesity induces alterations in lipid biochemistry, evolving toward dyslipidaemia atherogenesis, a critical factor in the development of cardiovascular events. Two relevant forms of lipid abnormalities are atherogenic dyslipidaemia (AD) and lipid triad (LT), which involve alterations in triglyceride levels, HDL-c, and LDL-c. The aim of this study was to assess the linkage of atherogenic AD and LT with different scales of overweight and obesity. We carried out a cross-sectional study including 418,343 Spanish adult workers, recruited from workplace health assessments. Atherogenic dyslipidaemia was defined as triglyceride levels ≥ 150 mg/dL, HDL values < 40 mg/dL in men and <45 mg/dL in women, and normal LDL. Additionally, if LDL levels were >160 mg/dL, LT was considered. Subjects affected by AD and LT in the study exhibited significantly higher mean values than those without AD and LT in all overweight, obesity, and body fat related scales studied. VAI (visceral adiposity index) was the strongest predictor of AD (AUC = 0.934, 95% CI: 0.933 to 0.936) and LT (AUC = 0.926, 95% CI: 0.923 to 0.928). Atherogenic dyslipidaemia and LT positively correlate with different scales of overweight and obesity. Further studies should aim to identify other contributory factors. Our obtained data might be useful in laying the groundwork for future works on AD and LT.
  

• 
  1.

  López-González Á A, Altisench Jané B, Masmiquel Comas L, Arroyo Bote S, González San Miguel HM, Ramírez Manent JI. Impact of COVID-19 Lockdown on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in Adults: A before and after Pandemic Lockdown Longitudinal Study. Nutrients [Internet]. MDPI AG; 2022 Jul.;14(14):2795. https://doi.org/10.3390%2Fnu14142795

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Non-alcoholic fatty liver disease is a chronic disease caused by the accumulation of fat in the liver related to overweight and obesity, insulin resistance, hyperglycemia, and high levels of triglycerides and leads to an increased cardiovascular risk. It is considered a global pandemic, coinciding with the pandemic in 2020 caused by the "coronavirus disease 2019" (COVID-19). Due to COVID-19, the population was placed under lockdown. The aim of our study was to evaluate how these unhealthy lifestyle modifications influenced the appearance of metabolic alterations and the increase in non-alcoholic fatty liver disease. METHODS: A prospective study was carried out on 6236 workers in a Spanish population between March 2019 and March 2021. RESULTS: Differences in the mean values of anthropometric and clinical parameters before and after lockdown were revealed. There was a statistically significant worsening in non-alcoholic fatty liver disease (NAFLD) and in the insulin resistance scales, with increased body weight, BMI, cholesterol levels with higher LDL levels, and glucose and a reduction in HDL levels. CONCLUSIONS: Lockdown caused a worsening of cardiovascular risk factors due to an increase in liver fat estimation scales and an increased risk of presenting with NAFLD and changes in insulin resistance.

  @article{lopezgonzaleza2022impact,
  abstract = {BACKGROUND: Non-alcoholic fatty liver disease is a chronic disease caused by the accumulation of fat in the liver related to overweight and obesity, insulin resistance, hyperglycemia, and high levels of triglycerides and leads to an increased cardiovascular risk. It is considered a global pandemic, coinciding with the pandemic in 2020 caused by the "coronavirus disease 2019" (COVID-19). Due to COVID-19, the population was placed under lockdown. The aim of our study was to evaluate how these unhealthy lifestyle modifications influenced the appearance of metabolic alterations and the increase in non-alcoholic fatty liver disease. METHODS: A prospective study was carried out on 6236 workers in a Spanish population between March 2019 and March 2021. RESULTS: Differences in the mean values of anthropometric and clinical parameters before and after lockdown were revealed. There was a statistically significant worsening in non-alcoholic fatty liver disease (NAFLD) and in the insulin resistance scales, with increased body weight, BMI, cholesterol levels with higher LDL levels, and glucose and a reduction in HDL levels. CONCLUSIONS: Lockdown caused a worsening of cardiovascular risk factors due to an increase in liver fat estimation scales and an increased risk of presenting with NAFLD and changes in insulin resistance.},
  author = {López-González Á, A. and Altisench Jané, B. and Masmiquel Comas, L. and Arroyo Bote, S. and González San Miguel, H. M. and Ramírez Manent, J. I.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {jul},
  number = 14,
  pages = 2795,
  publisher = {MDPI AG},
  title = {Impact of COVID-19 Lockdown on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in Adults: A before and after Pandemic Lockdown Longitudinal Study},
  volume = 14,
  year = 2022
  }
  

  %0 Journal Article
  %1 lopezgonzaleza2022impact
  %A López-González Á, A.
  %A Altisench Jané, B.
  %A Masmiquel Comas, L.
  %A Arroyo Bote, S.
  %A González San Miguel, H. M.
  %A Ramírez Manent, J. I.
  %D 2022
  %I MDPI AG
  %J Nutrients
  %N 14
  %P 2795
  %R 10.3390/nu14142795
  %T Impact of COVID-19 Lockdown on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in Adults: A before and after Pandemic Lockdown Longitudinal Study
  %U https://doi.org/10.3390%2Fnu14142795
  %V 14
  %X BACKGROUND: Non-alcoholic fatty liver disease is a chronic disease caused by the accumulation of fat in the liver related to overweight and obesity, insulin resistance, hyperglycemia, and high levels of triglycerides and leads to an increased cardiovascular risk. It is considered a global pandemic, coinciding with the pandemic in 2020 caused by the "coronavirus disease 2019" (COVID-19). Due to COVID-19, the population was placed under lockdown. The aim of our study was to evaluate how these unhealthy lifestyle modifications influenced the appearance of metabolic alterations and the increase in non-alcoholic fatty liver disease. METHODS: A prospective study was carried out on 6236 workers in a Spanish population between March 2019 and March 2021. RESULTS: Differences in the mean values of anthropometric and clinical parameters before and after lockdown were revealed. There was a statistically significant worsening in non-alcoholic fatty liver disease (NAFLD) and in the insulin resistance scales, with increased body weight, BMI, cholesterol levels with higher LDL levels, and glucose and a reduction in HDL levels. CONCLUSIONS: Lockdown caused a worsening of cardiovascular risk factors due to an increase in liver fat estimation scales and an increased risk of presenting with NAFLD and changes in insulin resistance.
  

• 
  1.

  García-Pazo P, Guillén-Solà M, Santos-Sopena OO, García-Avelló M, Bauzà-Amengual ML. The impact of COVID-19 on migrant women in son Gotleu (Palma) and the development of outreach tools to improve health and social care. J Adv Nurs [Internet]. 2022;78(5):1493-502. https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jan.15169?download=true

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  AIMS: The objectives of this research protocol are as follows: to examine the influence of the COVID-19 pandemic on health and social care for migrant women in the Son Gotleu district of Palma de Mallorca, Spain, and to develop outreach tools to target this specific group. DESIGN: This is a qualitative study that uses content analysis to obtain in-depth knowledge of personal experience (manifest content) and contextual experience (latent content) in a specific social setting. METHODS: The study population are migrant women living in Son Gotleu district, who are segmented by their age and experience of COVID-19, defined as positive or negative according to whether or not they have been infected with the disease. RESULTS: The shortcomings and needs relating to communication and health care that affect this group's current and future quality of life will be identified. CONCLUSION: The study of migrant women offers a gateway allowing vulnerability in health care to be detected. An awareness of their needs will allow prototype tools to be developed to facilitate communication and care for general and acute health needs between the scientific community and the vulnerable population.

  @article{RN11,
  abstract = {AIMS: The objectives of this research protocol are as follows: to examine the influence of the COVID-19 pandemic on health and social care for migrant women in the Son Gotleu district of Palma de Mallorca, Spain, and to develop outreach tools to target this specific group. DESIGN: This is a qualitative study that uses content analysis to obtain in-depth knowledge of personal experience (manifest content) and contextual experience (latent content) in a specific social setting. METHODS: The study population are migrant women living in Son Gotleu district, who are segmented by their age and experience of COVID-19, defined as positive or negative according to whether or not they have been infected with the disease. RESULTS: The shortcomings and needs relating to communication and health care that affect this group's current and future quality of life will be identified. CONCLUSION: The study of migrant women offers a gateway allowing vulnerability in health care to be detected. An awareness of their needs will allow prototype tools to be developed to facilitate communication and care for general and acute health needs between the scientific community and the vulnerable population.},
  author = {García-Pazo, P. and Guillén-Solà, M. and Santos-Sopena, O. O. and García-Avelló, M. and Bauzà-Amengual, M. L.},
  journal = {J Adv Nurs},
  keywords = {grapp-caib},
  number = 5,
  pages = {1493-1502},
  title = {The impact of COVID-19 on migrant women in son Gotleu (Palma) and the development of outreach tools to improve health and social care},
  type = {Journal Article},
  volume = 78,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN11
  %A García-Pazo, P.
  %A Guillén-Solà, M.
  %A Santos-Sopena, O. O.
  %A García-Avelló, M.
  %A Bauzà-Amengual, M. L.
  %D 2022
  %J J Adv Nurs
  %N 5
  %P 1493-1502
  %R 10.1111/jan.15169
  %T The impact of COVID-19 on migrant women in son Gotleu (Palma) and the development of outreach tools to improve health and social care
  %U https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jan.15169?download=true
  %V 78
  %X AIMS: The objectives of this research protocol are as follows: to examine the influence of the COVID-19 pandemic on health and social care for migrant women in the Son Gotleu district of Palma de Mallorca, Spain, and to develop outreach tools to target this specific group. DESIGN: This is a qualitative study that uses content analysis to obtain in-depth knowledge of personal experience (manifest content) and contextual experience (latent content) in a specific social setting. METHODS: The study population are migrant women living in Son Gotleu district, who are segmented by their age and experience of COVID-19, defined as positive or negative according to whether or not they have been infected with the disease. RESULTS: The shortcomings and needs relating to communication and health care that affect this group's current and future quality of life will be identified. CONCLUSION: The study of migrant women offers a gateway allowing vulnerability in health care to be detected. An awareness of their needs will allow prototype tools to be developed to facilitate communication and care for general and acute health needs between the scientific community and the vulnerable population.
  

• 
  1.

  Oliva-Fanlo B, March S, Gadea-Ruiz C, Stolper E, Esteva M, group O behalf of the C. Prospective Observational Study on the Prevalence and Diagnostic Value of General Practitioners’ Gut Feelings for Cancer and Serious Diseases. Journal of General Internal Medicine [Internet]. 2022 Jan. 27;. https://doi.org/10.1007/s11606-021-07352-w

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  General practitioners (GPs) have recognized the presence of gut feelings in their diagnostic process. However, little is known about the frequency or determinants of gut feelings or the diagnostic value of gut feelings for cancer and other serious diseases.

  @article{Oliva-Fanlo2022,
  abstract = {General practitioners (GPs) have recognized the presence of gut feelings in their diagnostic process. However, little is known about the frequency or determinants of gut feelings or the diagnostic value of gut feelings for cancer and other serious diseases.},
  author = {Oliva-Fanlo, Bernardino and March, Sebastià and Gadea-Ruiz, Cristina and Stolper, Erik and Esteva, Magdalena and On behalf of the CORap group},
  journal = {Journal of General Internal Medicine},
  keywords = {grapp-caib},
  month = {jan},
  title = {Prospective Observational Study on the Prevalence and Diagnostic Value of General Practitioners' Gut Feelings for Cancer and Serious Diseases},
  year = 2022
  }
  

  %0 Journal Article
  %1 Oliva-Fanlo2022
  %A Oliva-Fanlo, Bernardino
  %A March, Sebastià
  %A Gadea-Ruiz, Cristina
  %A Stolper, Erik
  %A Esteva, Magdalena
  %A group, On behalf of the CORap
  %D 2022
  %J Journal of General Internal Medicine
  %R 10.1007/s11606-021-07352-w
  %T Prospective Observational Study on the Prevalence and Diagnostic Value of General Practitioners' Gut Feelings for Cancer and Serious Diseases
  %U https://doi.org/10.1007/s11606-021-07352-w
  %X General practitioners (GPs) have recognized the presence of gut feelings in their diagnostic process. However, little is known about the frequency or determinants of gut feelings or the diagnostic value of gut feelings for cancer and other serious diseases.
  

• 
  1.

  León Salas B, de Pascual YMAM, Bilbao González A, Esteva Cantó M, de la Cruz Troca JJ, de la Cruz Troca JJ. [Content validation of the spanish version of the Long-term Quality of Life Instrument for long-term female breast cancer survivors.]. Rev Esp Salud Publica. 2022;96.

  AbstractBibTeXEndNoteBibSonomyDownload

  OBJECTIVE: The quality of life of women affected by breast cancer diagnosed 5 or more years ago has been relatively unexplored in Spain; there are no instruments for its measurement validated. The objective of the study is to translate into Spanish, culturally adapt and examine the content validity of the Spanish version of the Long-Term Quality of Life Instrument (LTQL). METHODS: The initial translation was performed by two translators with Spanish as their mother tongue carried out the translation of the questionnaire, obtaining two initial versions in Spanish (T1 and T2). An analysis of the results and elaboration of a single preliminary version in Spanish (T-1-2) were performed. The retro-translation was performed by two translators with English as their mother tongue not familiar with the original version translated the joint version (T-1-2) back into the original language (RT1 and RT2) to identify inconsistencies. Finally, a final version of the questionnaire was obtained. For content validation a committee of experts (seven women affected by breast cancer) assessed the degree of clarity, accuracy and understanding of each of the items in the questionnaire translated into Spanish, and calculated the content validity index (CVI) of the questionnaire according to Lawshe and Tristán. RESULTS: The LTQL questionnaire was translated into Spanish with a low discrepancy between translators. An adequate CVI higher than 0.58 was obtained in clarity (0.95), precision (0.93), comprehension (0.91) and relevance (0.72). CONCLUSIONS: The LTQL is a useful questionnaire in the health field for the assessment of quality of life of women survivors of long-term breast cancer.

  @article{RN13,
  abstract = {OBJECTIVE: The quality of life of women affected by breast cancer diagnosed 5 or more years ago has been relatively unexplored in Spain; there are no instruments for its measurement validated. The objective of the study is to translate into Spanish, culturally adapt and examine the content validity of the Spanish version of the Long-Term Quality of Life Instrument (LTQL). METHODS: The initial translation was performed by two translators with Spanish as their mother tongue carried out the translation of the questionnaire, obtaining two initial versions in Spanish (T1 and T2). An analysis of the results and elaboration of a single preliminary version in Spanish (T-1-2) were performed. The retro-translation was performed by two translators with English as their mother tongue not familiar with the original version translated the joint version (T-1-2) back into the original language (RT1 and RT2) to identify inconsistencies. Finally, a final version of the questionnaire was obtained. For content validation a committee of experts (seven women affected by breast cancer) assessed the degree of clarity, accuracy and understanding of each of the items in the questionnaire translated into Spanish, and calculated the content validity index (CVI) of the questionnaire according to Lawshe and Tristán. RESULTS: The LTQL questionnaire was translated into Spanish with a low discrepancy between translators. An adequate CVI higher than 0.58 was obtained in clarity (0.95), precision (0.93), comprehension (0.91) and relevance (0.72). CONCLUSIONS: The LTQL is a useful questionnaire in the health field for the assessment of quality of life of women survivors of long-term breast cancer.},
  author = {León Salas, B. and de Pascual, Y. Medina A. M. and Bilbao González, A. and Esteva Cantó, M. and de la Cruz Troca, J. J. and de la Cruz Troca, J. J.},
  journal = {Rev Esp Salud Publica},
  keywords = {grapp-caib},
  title = {[Content validation of the spanish version of the Long-term Quality of Life Instrument for long-term female breast cancer survivors.]},
  type = {Journal Article},
  volume = 96,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN13
  %A León Salas, B.
  %A de Pascual, Y. Medina A. M.
  %A Bilbao González, A.
  %A Esteva Cantó, M.
  %A de la Cruz Troca, J. J.
  %A de la Cruz Troca, J. J.
  %D 2022
  %J Rev Esp Salud Publica
  %T [Content validation of the spanish version of the Long-term Quality of Life Instrument for long-term female breast cancer survivors.]
  %V 96
  %X OBJECTIVE: The quality of life of women affected by breast cancer diagnosed 5 or more years ago has been relatively unexplored in Spain; there are no instruments for its measurement validated. The objective of the study is to translate into Spanish, culturally adapt and examine the content validity of the Spanish version of the Long-Term Quality of Life Instrument (LTQL). METHODS: The initial translation was performed by two translators with Spanish as their mother tongue carried out the translation of the questionnaire, obtaining two initial versions in Spanish (T1 and T2). An analysis of the results and elaboration of a single preliminary version in Spanish (T-1-2) were performed. The retro-translation was performed by two translators with English as their mother tongue not familiar with the original version translated the joint version (T-1-2) back into the original language (RT1 and RT2) to identify inconsistencies. Finally, a final version of the questionnaire was obtained. For content validation a committee of experts (seven women affected by breast cancer) assessed the degree of clarity, accuracy and understanding of each of the items in the questionnaire translated into Spanish, and calculated the content validity index (CVI) of the questionnaire according to Lawshe and Tristán. RESULTS: The LTQL questionnaire was translated into Spanish with a low discrepancy between translators. An adequate CVI higher than 0.58 was obtained in clarity (0.95), precision (0.93), comprehension (0.91) and relevance (0.72). CONCLUSIONS: The LTQL is a useful questionnaire in the health field for the assessment of quality of life of women survivors of long-term breast cancer.
  

• 
  1.

  López-González Á A, Manzanero Z, González San Miguel HM, Arroyo Bote S, Riutord Sbert P, Rigo Vives MDM, Ramírez Manent JI. Differences in cardiovascular risk levels between cleaning staff and hotel housekeepers. J Occup Health [Internet]. 2022;64(1):e12320. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886290/pdf/JOH2-64-e12320.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND AND OBJECTIVE: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, with a greater incidence in the most disadvantaged social classes. In this study, we aimed to evaluate the level of cardiovascular risk in cleaning workers. METHODS: This was a descriptive, cross-sectional study in 46.632 cleaning workers (40.169 women and 6.463 men). Thirty-one different scales related to cardiovascular risk were studied (14 assessing overweight and obesity, 5 determining the risk of nonalcoholic fatty liver disease, 5 scales of cardiovascular risk, 4 atherogenic indices, and 3 scales of metabolic syndrome, among others). The results obtained were divided between personnel who perform their cleaning tasks in the hotel and catering industry and those in other sectors. RESULTS: The prevalence of obesity and arterial hypertension in cleaning workers was over 20% in both sexes. A similar amount was observed in moderate or high values on the REGICOR (Registre GIroní del COR) scale. More than 15% presented metabolic syndrome according to the NCEP ATPIII (National Cholesterol Education Program-Adult Treatment Program III) criteria, while over 10% of women and 20% of men had a high risk of nonalcoholic fatty liver disease assessed with the fatty liver index. CONCLUSION: Cardiovascular risk is higher, in both sexes, in the group of cleaning workers who work in companies other than hotels.

  @article{RN10,
  abstract = {BACKGROUND AND OBJECTIVE: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, with a greater incidence in the most disadvantaged social classes. In this study, we aimed to evaluate the level of cardiovascular risk in cleaning workers. METHODS: This was a descriptive, cross-sectional study in 46.632 cleaning workers (40.169 women and 6.463 men). Thirty-one different scales related to cardiovascular risk were studied (14 assessing overweight and obesity, 5 determining the risk of nonalcoholic fatty liver disease, 5 scales of cardiovascular risk, 4 atherogenic indices, and 3 scales of metabolic syndrome, among others). The results obtained were divided between personnel who perform their cleaning tasks in the hotel and catering industry and those in other sectors. RESULTS: The prevalence of obesity and arterial hypertension in cleaning workers was over 20% in both sexes. A similar amount was observed in moderate or high values on the REGICOR (Registre GIroní del COR) scale. More than 15% presented metabolic syndrome according to the NCEP ATPIII (National Cholesterol Education Program-Adult Treatment Program III) criteria, while over 10% of women and 20% of men had a high risk of nonalcoholic fatty liver disease assessed with the fatty liver index. CONCLUSION: Cardiovascular risk is higher, in both sexes, in the group of cleaning workers who work in companies other than hotels.},
  author = {López-González Á, A. and Manzanero, Z. and González San Miguel, H. M. and Arroyo Bote, S. and Riutord Sbert, P. and Rigo Vives, M. D. M. and Ramírez Manent, J. I.},
  journal = {J Occup Health},
  keywords = {grapp-caib},
  number = 1,
  pages = {e12320},
  title = {Differences in cardiovascular risk levels between cleaning staff and hotel housekeepers},
  type = {Journal Article},
  volume = 64,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN10
  %A López-González Á, A.
  %A Manzanero, Z.
  %A González San Miguel, H. M.
  %A Arroyo Bote, S.
  %A Riutord Sbert, P.
  %A Rigo Vives, M. D. M.
  %A Ramírez Manent, J. I.
  %D 2022
  %J J Occup Health
  %N 1
  %P e12320
  %R 10.1002/1348-9585.12320
  %T Differences in cardiovascular risk levels between cleaning staff and hotel housekeepers
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886290/pdf/JOH2-64-e12320.pdf
  %V 64
  %X BACKGROUND AND OBJECTIVE: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, with a greater incidence in the most disadvantaged social classes. In this study, we aimed to evaluate the level of cardiovascular risk in cleaning workers. METHODS: This was a descriptive, cross-sectional study in 46.632 cleaning workers (40.169 women and 6.463 men). Thirty-one different scales related to cardiovascular risk were studied (14 assessing overweight and obesity, 5 determining the risk of nonalcoholic fatty liver disease, 5 scales of cardiovascular risk, 4 atherogenic indices, and 3 scales of metabolic syndrome, among others). The results obtained were divided between personnel who perform their cleaning tasks in the hotel and catering industry and those in other sectors. RESULTS: The prevalence of obesity and arterial hypertension in cleaning workers was over 20% in both sexes. A similar amount was observed in moderate or high values on the REGICOR (Registre GIroní del COR) scale. More than 15% presented metabolic syndrome according to the NCEP ATPIII (National Cholesterol Education Program-Adult Treatment Program III) criteria, while over 10% of women and 20% of men had a high risk of nonalcoholic fatty liver disease assessed with the fatty liver index. CONCLUSION: Cardiovascular risk is higher, in both sexes, in the group of cleaning workers who work in companies other than hotels.
  

• 
  1.

  Lugones-Sanchez C, Recio-Rodriguez JI, Agudo-Conde C, Repiso-Gento I, E GA, Ramirez-Manent JI, Sanchez-Calavera MA, Rodriguez-Sanchez E, Gomez-Marcos MA, Garcia-Ortiz L. Long-term Effectiveness of a Smartphone App Combined With a Smart Band on Weight Loss, Physical Activity, and Caloric Intake in a Population With Overweight and Obesity (Evident 3 Study): Randomized Controlled Trial. J Med Internet Res. 2022;24(2):e30416.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Multicomponent mobile health approaches can improve lifestyle intervention results, although little is known about their long-term effectiveness. OBJECTIVE: This study aims to evaluate the long-term effectiveness (12 months) of a multicomponent mobile health intervention-combining a smartphone app, an activity tracker wristband, and brief counseling, compared with a brief counseling group only-on weight loss and improving body composition, physical activity, and caloric intake in Spanish sedentary adults with overweight or obesity. METHODS: We conducted a randomized controlled, multicenter clinical trial (Evident 3). A total of 650 participants were recruited from 5 primary care centers, with 318 participants in the intervention group (IG) and 332 in the control group (CG). All participants were briefly counseled about a healthy diet and physical activity at the baseline visit. For the 3-month intervention period, the IG received training to use the app to promote healthy lifestyles and the smart band (Mi Band 2, Xiaomi). All measurements were performed at baseline and at 3 and 12 months. Physical activity was measured using the International Physical Activity Questionnaire-Short Form. Nutritional habits were assessed using the Food Frequency Questionnaire and Adherence to Mediterranean diet questionnaire. RESULTS: Of the 650 participants included, 563 (86.6%) completed the 3-month visit and 443 (68.2%) completed the 12-month visit. After 12 months, the IG showed net differences in weight (-0.26, 95% CI -1.21 to 0.70 kg; P=.02), BMI (-0.06, 95% CI -0.41 to 0.28 points; P=.01), waist-height ratio (-0.25, 95% CI -0.94 to 0.44; P=.03), body adiposity index (-0.33, 95% CI -0.77 to 0.11; P=.03), waist circumference (-0.48, 95% CI -1.62 to 0.66 cm, P=.04) and hip circumference (-0.69, 95% CI -1.62 to 0.25 cm; P=.03). Both groups lowered daily caloric intake and increased adherence to the Mediterranean diet, with no differences between the groups. The IG increased light physical activity time (32.6, 95% CI -30.3 to 95.04 min/week; P=.02) compared with the CG. Analyses by subgroup showed changes in body composition variables in women, people aged >50 years, and married people. CONCLUSIONS: The low-intensity intervention of the Evident 3 study showed, in the IG, benefits in weight loss, some body composition variables, and time spent in light physical activity compared with the CG at 3 months, but once the devices were collected, the downward trend was not maintained at the 12-month follow-up. No differences in nutritional outcomes were observed between the groups. TRIAL REGISTRATION: ClinicalTrials.gov NCT03175614; https://clinicaltrials.gov/ct2/show/NCT03175614. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1097/MD.0000000000009633.

  @article{RN14,
  abstract = {BACKGROUND: Multicomponent mobile health approaches can improve lifestyle intervention results, although little is known about their long-term effectiveness. OBJECTIVE: This study aims to evaluate the long-term effectiveness (12 months) of a multicomponent mobile health intervention-combining a smartphone app, an activity tracker wristband, and brief counseling, compared with a brief counseling group only-on weight loss and improving body composition, physical activity, and caloric intake in Spanish sedentary adults with overweight or obesity. METHODS: We conducted a randomized controlled, multicenter clinical trial (Evident 3). A total of 650 participants were recruited from 5 primary care centers, with 318 participants in the intervention group (IG) and 332 in the control group (CG). All participants were briefly counseled about a healthy diet and physical activity at the baseline visit. For the 3-month intervention period, the IG received training to use the app to promote healthy lifestyles and the smart band (Mi Band 2, Xiaomi). All measurements were performed at baseline and at 3 and 12 months. Physical activity was measured using the International Physical Activity Questionnaire-Short Form. Nutritional habits were assessed using the Food Frequency Questionnaire and Adherence to Mediterranean diet questionnaire. RESULTS: Of the 650 participants included, 563 (86.6%) completed the 3-month visit and 443 (68.2%) completed the 12-month visit. After 12 months, the IG showed net differences in weight (-0.26, 95% CI -1.21 to 0.70 kg; P=.02), BMI (-0.06, 95% CI -0.41 to 0.28 points; P=.01), waist-height ratio (-0.25, 95% CI -0.94 to 0.44; P=.03), body adiposity index (-0.33, 95% CI -0.77 to 0.11; P=.03), waist circumference (-0.48, 95% CI -1.62 to 0.66 cm, P=.04) and hip circumference (-0.69, 95% CI -1.62 to 0.25 cm; P=.03). Both groups lowered daily caloric intake and increased adherence to the Mediterranean diet, with no differences between the groups. The IG increased light physical activity time (32.6, 95% CI -30.3 to 95.04 min/week; P=.02) compared with the CG. Analyses by subgroup showed changes in body composition variables in women, people aged >50 years, and married people. CONCLUSIONS: The low-intensity intervention of the Evident 3 study showed, in the IG, benefits in weight loss, some body composition variables, and time spent in light physical activity compared with the CG at 3 months, but once the devices were collected, the downward trend was not maintained at the 12-month follow-up. No differences in nutritional outcomes were observed between the groups. TRIAL REGISTRATION: ClinicalTrials.gov NCT03175614; https://clinicaltrials.gov/ct2/show/NCT03175614. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1097/MD.0000000000009633.},
  author = {Lugones-Sanchez, C. and Recio-Rodriguez, J. I. and Agudo-Conde, C. and Repiso-Gento, I. and E, G. Adalia and Ramirez-Manent, J. I. and Sanchez-Calavera, M. A. and Rodriguez-Sanchez, E. and Gomez-Marcos, M. A. and Garcia-Ortiz, L.},
  journal = {J Med Internet Res},
  keywords = {grapp-caib},
  number = 2,
  pages = {e30416},
  title = {Long-term Effectiveness of a Smartphone App Combined With a Smart Band on Weight Loss, Physical Activity, and Caloric Intake in a Population With Overweight and Obesity (Evident 3 Study): Randomized Controlled Trial},
  type = {Journal Article},
  volume = 24,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN14
  %A Lugones-Sanchez, C.
  %A Recio-Rodriguez, J. I.
  %A Agudo-Conde, C.
  %A Repiso-Gento, I.
  %A E, G. Adalia
  %A Ramirez-Manent, J. I.
  %A Sanchez-Calavera, M. A.
  %A Rodriguez-Sanchez, E.
  %A Gomez-Marcos, M. A.
  %A Garcia-Ortiz, L.
  %D 2022
  %J J Med Internet Res
  %N 2
  %P e30416
  %R 10.2196/30416
  %T Long-term Effectiveness of a Smartphone App Combined With a Smart Band on Weight Loss, Physical Activity, and Caloric Intake in a Population With Overweight and Obesity (Evident 3 Study): Randomized Controlled Trial
  %V 24
  %X BACKGROUND: Multicomponent mobile health approaches can improve lifestyle intervention results, although little is known about their long-term effectiveness. OBJECTIVE: This study aims to evaluate the long-term effectiveness (12 months) of a multicomponent mobile health intervention-combining a smartphone app, an activity tracker wristband, and brief counseling, compared with a brief counseling group only-on weight loss and improving body composition, physical activity, and caloric intake in Spanish sedentary adults with overweight or obesity. METHODS: We conducted a randomized controlled, multicenter clinical trial (Evident 3). A total of 650 participants were recruited from 5 primary care centers, with 318 participants in the intervention group (IG) and 332 in the control group (CG). All participants were briefly counseled about a healthy diet and physical activity at the baseline visit. For the 3-month intervention period, the IG received training to use the app to promote healthy lifestyles and the smart band (Mi Band 2, Xiaomi). All measurements were performed at baseline and at 3 and 12 months. Physical activity was measured using the International Physical Activity Questionnaire-Short Form. Nutritional habits were assessed using the Food Frequency Questionnaire and Adherence to Mediterranean diet questionnaire. RESULTS: Of the 650 participants included, 563 (86.6%) completed the 3-month visit and 443 (68.2%) completed the 12-month visit. After 12 months, the IG showed net differences in weight (-0.26, 95% CI -1.21 to 0.70 kg; P=.02), BMI (-0.06, 95% CI -0.41 to 0.28 points; P=.01), waist-height ratio (-0.25, 95% CI -0.94 to 0.44; P=.03), body adiposity index (-0.33, 95% CI -0.77 to 0.11; P=.03), waist circumference (-0.48, 95% CI -1.62 to 0.66 cm, P=.04) and hip circumference (-0.69, 95% CI -1.62 to 0.25 cm; P=.03). Both groups lowered daily caloric intake and increased adherence to the Mediterranean diet, with no differences between the groups. The IG increased light physical activity time (32.6, 95% CI -30.3 to 95.04 min/week; P=.02) compared with the CG. Analyses by subgroup showed changes in body composition variables in women, people aged >50 years, and married people. CONCLUSIONS: The low-intensity intervention of the Evident 3 study showed, in the IG, benefits in weight loss, some body composition variables, and time spent in light physical activity compared with the CG at 3 months, but once the devices were collected, the downward trend was not maintained at the 12-month follow-up. No differences in nutritional outcomes were observed between the groups. TRIAL REGISTRATION: ClinicalTrials.gov NCT03175614; https://clinicaltrials.gov/ct2/show/NCT03175614. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1097/MD.0000000000009633.
  

• 
  1.

  Sarabia-Cobo C, Taltavull JM, Lladó-Jordan G, González S, Molina-Mula J, Ortego-Mate C, Fernández-Peña R. Comparison between attention and experiences of chronic complex patients: A multicentric study. Health Soc Care Community [Internet]. 2022;30(3):976-87. https://onlinelibrary.wiley.com/doi/10.1111/hsc.13269

  AbstractURLBibTeXEndNoteDOIBibSonomy

  The aim of this research is to explore and analyse the functional status and experiences of complex patients located at levels 3-4 of the risk pyramid of the chronic care model in primary care, within the hospital system of two regions in Spain. The design was a mixed design (COREQ). The participants were enrolled in programs for chronic complex patients and their caregivers. Sociodemographic variables were gathered, together with the following measures: the Barthel test, the Mini mental test, the Zarit questionnaire, the IEXPAC scale and the Braden scale. A semi-structured interview was conducted individually with patients in order to explore their experiences and narrative on the process of their illness and the support they had received. The sample comprised 206 chronic pluripathological patients, of whom 103 were from Cantabria and a further 103 were from Mallorca. The patient profile in both regions was very similar. There was an equal distribution across both gender and the patients were over 78 years old. They all had a basic (primary) education, an average income and required moderate physical dependence, receiving assistance primarily from their children. The qualitative analysis highlighted patients' awareness of the illness and their concern for the future, noting that, overall, patients were satisfied with the care provided by their caregivers and the health system. We can conclude that is the first multicentric study of these characteristics conducted in Spain, despite it being the country with the second largest ageing population in the world. It is important to test new organisational models with differentiating areas of advanced clinical practice in primary care, whereby both patients and their caregivers can be co-responsible within the care process.

  @article{RN4,
  abstract = {The aim of this research is to explore and analyse the functional status and experiences of complex patients located at levels 3-4 of the risk pyramid of the chronic care model in primary care, within the hospital system of two regions in Spain. The design was a mixed design (COREQ). The participants were enrolled in programs for chronic complex patients and their caregivers. Sociodemographic variables were gathered, together with the following measures: the Barthel test, the Mini mental test, the Zarit questionnaire, the IEXPAC scale and the Braden scale. A semi-structured interview was conducted individually with patients in order to explore their experiences and narrative on the process of their illness and the support they had received. The sample comprised 206 chronic pluripathological patients, of whom 103 were from Cantabria and a further 103 were from Mallorca. The patient profile in both regions was very similar. There was an equal distribution across both gender and the patients were over 78 years old. They all had a basic (primary) education, an average income and required moderate physical dependence, receiving assistance primarily from their children. The qualitative analysis highlighted patients' awareness of the illness and their concern for the future, noting that, overall, patients were satisfied with the care provided by their caregivers and the health system. We can conclude that is the first multicentric study of these characteristics conducted in Spain, despite it being the country with the second largest ageing population in the world. It is important to test new organisational models with differentiating areas of advanced clinical practice in primary care, whereby both patients and their caregivers can be co-responsible within the care process.},
  author = {Sarabia-Cobo, C. and Taltavull, J. M. and Lladó-Jordan, G. and González, S. and Molina-Mula, J. and Ortego-Mate, C. and Fernández-Peña, R.},
  journal = {Health Soc Care Community},
  keywords = {grapp-caib},
  number = 3,
  pages = {976-987},
  title = {Comparison between attention and experiences of chronic complex patients: A multicentric study},
  type = {Journal Article},
  volume = 30,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN4
  %A Sarabia-Cobo, C.
  %A Taltavull, J. M.
  %A Lladó-Jordan, G.
  %A González, S.
  %A Molina-Mula, J.
  %A Ortego-Mate, C.
  %A Fernández-Peña, R.
  %D 2022
  %J Health Soc Care Community
  %N 3
  %P 976-987
  %R 10.1111/hsc.13269
  %T Comparison between attention and experiences of chronic complex patients: A multicentric study
  %U https://onlinelibrary.wiley.com/doi/10.1111/hsc.13269
  %V 30
  %X The aim of this research is to explore and analyse the functional status and experiences of complex patients located at levels 3-4 of the risk pyramid of the chronic care model in primary care, within the hospital system of two regions in Spain. The design was a mixed design (COREQ). The participants were enrolled in programs for chronic complex patients and their caregivers. Sociodemographic variables were gathered, together with the following measures: the Barthel test, the Mini mental test, the Zarit questionnaire, the IEXPAC scale and the Braden scale. A semi-structured interview was conducted individually with patients in order to explore their experiences and narrative on the process of their illness and the support they had received. The sample comprised 206 chronic pluripathological patients, of whom 103 were from Cantabria and a further 103 were from Mallorca. The patient profile in both regions was very similar. There was an equal distribution across both gender and the patients were over 78 years old. They all had a basic (primary) education, an average income and required moderate physical dependence, receiving assistance primarily from their children. The qualitative analysis highlighted patients' awareness of the illness and their concern for the future, noting that, overall, patients were satisfied with the care provided by their caregivers and the health system. We can conclude that is the first multicentric study of these characteristics conducted in Spain, despite it being the country with the second largest ageing population in the world. It is important to test new organisational models with differentiating areas of advanced clinical practice in primary care, whereby both patients and their caregivers can be co-responsible within the care process.
  

• 
  1.

  Serrano-Ripoll MJ, Fiol deRoque MA, Valderas JM, Zamanillo-Campos R, Llobera J, de Labry Lima AO, Pastor-Moreno G, Ricci-Cabello I. Feasibility of the SINERGIAPS ("Sinergias entre profesionales y pacientes para una Atención Primaria Segura") intervention for improving patient safety in primary care. Fam Pract [Internet]. 2022;. https://academic.oup.com/fampra/advance-article-abstract/doi/10.1093/fampra/cmac015/6543662?redirectedFrom=fulltext

  AbstractURLBibTeXEndNoteDOIBibSonomy

  AIM: The primary aim was to examine the feasibility of intervention delivery and of trial procedures. Secondary aims were to study the intervention uptake; its acceptability and perceived utility; and its potential to improve safety culture and avoidable hospital admissions. METHODS: We conducted a 3-month, single-arm feasibility study in 10 primary care (PC) centres in Spain. Centres received information regarding patients' experiences of safety (through the Patient Reported Experiences and Outcomes of Safety in Primary Care [PREOS-PC] questionnaire), and were instructed to plan safety improvements based on that feedback. We used a bespoke online tool to recruit PC professionals, collect patient feedback, and deliver it to the centres, and to collect outcome data (patient safety culture [Medical Office Survey on Patient Safety Culture, MOSPSC questionnaire]). We measured recruitment and follow-up rates and intervention uptake (based on the number of safety improvement plans registered). We conducted semistructured interviews with 9 professionals to explore the intervention acceptability and perceived utility. RESULTS: Of 256 professionals invited, 120 (47%) agreed to participate, and 97 completed baseline and postintervention measures. Of 780 patients invited, 585 (75%) completed the PREOS-PC questionnaire. Five of 10 centres (50%) designed an improvement plan, providing 27 plans in total (range per centre, 1-14). The intervention was perceived as a novel strategy for improving safety, although the healthcare professionals identified several factors limiting its acceptability and utility: lack of feedback at the individual professional level; potentially unrepresentative sample of patients providing feedback; and number of educational materials deemed overwhelming. DISCUSSION: It is feasible to deliver the proposed intervention so long as the identified limitations are addressed.

  @article{RN9,
  abstract = {AIM: The primary aim was to examine the feasibility of intervention delivery and of trial procedures. Secondary aims were to study the intervention uptake; its acceptability and perceived utility; and its potential to improve safety culture and avoidable hospital admissions. METHODS: We conducted a 3-month, single-arm feasibility study in 10 primary care (PC) centres in Spain. Centres received information regarding patients' experiences of safety (through the Patient Reported Experiences and Outcomes of Safety in Primary Care [PREOS-PC] questionnaire), and were instructed to plan safety improvements based on that feedback. We used a bespoke online tool to recruit PC professionals, collect patient feedback, and deliver it to the centres, and to collect outcome data (patient safety culture [Medical Office Survey on Patient Safety Culture, MOSPSC questionnaire]). We measured recruitment and follow-up rates and intervention uptake (based on the number of safety improvement plans registered). We conducted semistructured interviews with 9 professionals to explore the intervention acceptability and perceived utility. RESULTS: Of 256 professionals invited, 120 (47%) agreed to participate, and 97 completed baseline and postintervention measures. Of 780 patients invited, 585 (75%) completed the PREOS-PC questionnaire. Five of 10 centres (50%) designed an improvement plan, providing 27 plans in total (range per centre, 1-14). The intervention was perceived as a novel strategy for improving safety, although the healthcare professionals identified several factors limiting its acceptability and utility: lack of feedback at the individual professional level; potentially unrepresentative sample of patients providing feedback; and number of educational materials deemed overwhelming. DISCUSSION: It is feasible to deliver the proposed intervention so long as the identified limitations are addressed.},
  author = {Serrano-Ripoll, M. J. and Fiol deRoque, M. A. and Valderas, J. M. and Zamanillo-Campos, R. and Llobera, J. and de Labry Lima, A. O. and Pastor-Moreno, G. and Ricci-Cabello, I.},
  journal = {Fam Pract},
  keywords = {grapp-caib myown},
  title = {Feasibility of the SINERGIAPS ("Sinergias entre profesionales y pacientes para una Atención Primaria Segura") intervention for improving patient safety in primary care},
  type = {Journal Article},
  year = 2022
  }
  

  %0 Journal Article
  %1 RN9
  %A Serrano-Ripoll, M. J.
  %A Fiol deRoque, M. A.
  %A Valderas, J. M.
  %A Zamanillo-Campos, R.
  %A Llobera, J.
  %A de Labry Lima, A. O.
  %A Pastor-Moreno, G.
  %A Ricci-Cabello, I.
  %D 2022
  %J Fam Pract
  %R 10.1093/fampra/cmac015
  %T Feasibility of the SINERGIAPS ("Sinergias entre profesionales y pacientes para una Atención Primaria Segura") intervention for improving patient safety in primary care
  %U https://academic.oup.com/fampra/advance-article-abstract/doi/10.1093/fampra/cmac015/6543662?redirectedFrom=fulltext
  %X AIM: The primary aim was to examine the feasibility of intervention delivery and of trial procedures. Secondary aims were to study the intervention uptake; its acceptability and perceived utility; and its potential to improve safety culture and avoidable hospital admissions. METHODS: We conducted a 3-month, single-arm feasibility study in 10 primary care (PC) centres in Spain. Centres received information regarding patients' experiences of safety (through the Patient Reported Experiences and Outcomes of Safety in Primary Care [PREOS-PC] questionnaire), and were instructed to plan safety improvements based on that feedback. We used a bespoke online tool to recruit PC professionals, collect patient feedback, and deliver it to the centres, and to collect outcome data (patient safety culture [Medical Office Survey on Patient Safety Culture, MOSPSC questionnaire]). We measured recruitment and follow-up rates and intervention uptake (based on the number of safety improvement plans registered). We conducted semistructured interviews with 9 professionals to explore the intervention acceptability and perceived utility. RESULTS: Of 256 professionals invited, 120 (47%) agreed to participate, and 97 completed baseline and postintervention measures. Of 780 patients invited, 585 (75%) completed the PREOS-PC questionnaire. Five of 10 centres (50%) designed an improvement plan, providing 27 plans in total (range per centre, 1-14). The intervention was perceived as a novel strategy for improving safety, although the healthcare professionals identified several factors limiting its acceptability and utility: lack of feedback at the individual professional level; potentially unrepresentative sample of patients providing feedback; and number of educational materials deemed overwhelming. DISCUSSION: It is feasible to deliver the proposed intervention so long as the identified limitations are addressed.
  

• 
  1.

  Serrano-Ripoll MJ, Zamanillo-Campos R, Fiol-DeRoque MA, Castro A, Ricci-Cabello I. Impact of Smartphone App-Based Psychological Interventions for Reducing Depressive Symptoms in People With Depression: Systematic Literature Review and Meta-analysis of Randomized Controlled Trials. JMIR Mhealth Uhealth. 2022;10(1):e29621.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Depression is a serious, disabling mental disorder that severely affects quality of life. Patients with depression often do not receive adequate treatment. App-based psychotherapy is considered to have great potential to treat depression owing to its reach and easy accessibility. OBJECTIVE: We aim to analyze the impact of app-based psychological interventions for reducing depressive symptoms in people with depression. METHODS: We conducted a systematic literature review and meta-analysis. We searched Medline, Embase, PsycINFO, Web of Science, and Cochrane Central Register of Controlled Trials from inception to December 23, 2020. We selected randomized controlled trials to examine the impact of app-based psychological interventions for reducing depressive symptoms in people with depression. Study selection, data extraction, and critical appraisal (using the Cochrane Risk of Bias tool for randomized studies and the ROBINS-I tool for nonrandomized studies) were conducted independently by 2 reviewers. Where possible, we pooled data using random effects meta-analyses to obtain estimates of the effect size of the intervention. We conducted post hoc meta-regression analyses to explore the factors associated with intervention success. RESULTS: After screening 3468 unique references retrieved from bibliographic searches and assessing the eligibility of 79 full texts, we identified 12 trials (2859 participants) evaluating 14 different interventions. Of 14 trials, 7 (58%) were conducted in the United States; 3 (25%) trials, in Asia (Japan, South Korea, and China); 1 (8%) trial, in Australia; and 1 (8%) trial, in Germany. Of the 12 trials, 5 (42%) trials presented a low risk of bias. The mean duration of the interventions was 6.6 (SD 2.8) weeks. Two-thirds of the interventions were based on cognitive behavioral therapy alone or included it in combination with cognitive control therapy, positive psychology, brief behavioral activation, or mindfulness- and acceptance-based therapy. With no evidence of publication bias, a pooled analysis of 83% (10/12) of the trials and 86% (12/14) of the interventions showed that app-based interventions, compared with a control group receiving usual care or minimal intervention, produced a moderate reduction in depressive symptoms (standardized mean difference [SMD] -0.51, 95% CI -0.69 to -0.33; 2018/2859, 70.58% of the participants; I(2)=70%). Our meta-regression analyses indicated that there was a greater reduction in symptoms of depression (P=.04) in trials that included participants with moderate to severe depression (SMD -0.67, 95% CI -0.79 to -0.55), compared with trials with participants exhibiting mild to moderate depression (SMD -0.15, 95% CI -0.43 to -0.12). CONCLUSIONS: App-based interventions targeted at people with depression produce moderate reductions in the symptoms of depression. More methodologically robust trials are needed to confirm our findings, determine which intervention features are associated with greater improvements, and identify those populations most likely to benefit from this type of intervention. TRIAL REGISTRATION: PROSPERO CRD42019145689; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=145689.

  @article{RN16,
  abstract = {BACKGROUND: Depression is a serious, disabling mental disorder that severely affects quality of life. Patients with depression often do not receive adequate treatment. App-based psychotherapy is considered to have great potential to treat depression owing to its reach and easy accessibility. OBJECTIVE: We aim to analyze the impact of app-based psychological interventions for reducing depressive symptoms in people with depression. METHODS: We conducted a systematic literature review and meta-analysis. We searched Medline, Embase, PsycINFO, Web of Science, and Cochrane Central Register of Controlled Trials from inception to December 23, 2020. We selected randomized controlled trials to examine the impact of app-based psychological interventions for reducing depressive symptoms in people with depression. Study selection, data extraction, and critical appraisal (using the Cochrane Risk of Bias tool for randomized studies and the ROBINS-I tool for nonrandomized studies) were conducted independently by 2 reviewers. Where possible, we pooled data using random effects meta-analyses to obtain estimates of the effect size of the intervention. We conducted post hoc meta-regression analyses to explore the factors associated with intervention success. RESULTS: After screening 3468 unique references retrieved from bibliographic searches and assessing the eligibility of 79 full texts, we identified 12 trials (2859 participants) evaluating 14 different interventions. Of 14 trials, 7 (58%) were conducted in the United States; 3 (25%) trials, in Asia (Japan, South Korea, and China); 1 (8%) trial, in Australia; and 1 (8%) trial, in Germany. Of the 12 trials, 5 (42%) trials presented a low risk of bias. The mean duration of the interventions was 6.6 (SD 2.8) weeks. Two-thirds of the interventions were based on cognitive behavioral therapy alone or included it in combination with cognitive control therapy, positive psychology, brief behavioral activation, or mindfulness- and acceptance-based therapy. With no evidence of publication bias, a pooled analysis of 83% (10/12) of the trials and 86% (12/14) of the interventions showed that app-based interventions, compared with a control group receiving usual care or minimal intervention, produced a moderate reduction in depressive symptoms (standardized mean difference [SMD] -0.51, 95% CI -0.69 to -0.33; 2018/2859, 70.58% of the participants; I(2)=70%). Our meta-regression analyses indicated that there was a greater reduction in symptoms of depression (P=.04) in trials that included participants with moderate to severe depression (SMD -0.67, 95% CI -0.79 to -0.55), compared with trials with participants exhibiting mild to moderate depression (SMD -0.15, 95% CI -0.43 to -0.12). CONCLUSIONS: App-based interventions targeted at people with depression produce moderate reductions in the symptoms of depression. More methodologically robust trials are needed to confirm our findings, determine which intervention features are associated with greater improvements, and identify those populations most likely to benefit from this type of intervention. TRIAL REGISTRATION: PROSPERO CRD42019145689; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=145689.},
  author = {Serrano-Ripoll, M. J. and Zamanillo-Campos, R. and Fiol-DeRoque, M. A. and Castro, A. and Ricci-Cabello, I.},
  journal = {JMIR Mhealth Uhealth},
  keywords = {grapp-caib myown},
  number = 1,
  pages = {e29621},
  title = {Impact of Smartphone App-Based Psychological Interventions for Reducing Depressive Symptoms in People With Depression: Systematic Literature Review and Meta-analysis of Randomized Controlled Trials},
  type = {Journal Article},
  volume = 10,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN16
  %A Serrano-Ripoll, M. J.
  %A Zamanillo-Campos, R.
  %A Fiol-DeRoque, M. A.
  %A Castro, A.
  %A Ricci-Cabello, I.
  %D 2022
  %J JMIR Mhealth Uhealth
  %N 1
  %P e29621
  %R 10.2196/29621
  %T Impact of Smartphone App-Based Psychological Interventions for Reducing Depressive Symptoms in People With Depression: Systematic Literature Review and Meta-analysis of Randomized Controlled Trials
  %V 10
  %X BACKGROUND: Depression is a serious, disabling mental disorder that severely affects quality of life. Patients with depression often do not receive adequate treatment. App-based psychotherapy is considered to have great potential to treat depression owing to its reach and easy accessibility. OBJECTIVE: We aim to analyze the impact of app-based psychological interventions for reducing depressive symptoms in people with depression. METHODS: We conducted a systematic literature review and meta-analysis. We searched Medline, Embase, PsycINFO, Web of Science, and Cochrane Central Register of Controlled Trials from inception to December 23, 2020. We selected randomized controlled trials to examine the impact of app-based psychological interventions for reducing depressive symptoms in people with depression. Study selection, data extraction, and critical appraisal (using the Cochrane Risk of Bias tool for randomized studies and the ROBINS-I tool for nonrandomized studies) were conducted independently by 2 reviewers. Where possible, we pooled data using random effects meta-analyses to obtain estimates of the effect size of the intervention. We conducted post hoc meta-regression analyses to explore the factors associated with intervention success. RESULTS: After screening 3468 unique references retrieved from bibliographic searches and assessing the eligibility of 79 full texts, we identified 12 trials (2859 participants) evaluating 14 different interventions. Of 14 trials, 7 (58%) were conducted in the United States; 3 (25%) trials, in Asia (Japan, South Korea, and China); 1 (8%) trial, in Australia; and 1 (8%) trial, in Germany. Of the 12 trials, 5 (42%) trials presented a low risk of bias. The mean duration of the interventions was 6.6 (SD 2.8) weeks. Two-thirds of the interventions were based on cognitive behavioral therapy alone or included it in combination with cognitive control therapy, positive psychology, brief behavioral activation, or mindfulness- and acceptance-based therapy. With no evidence of publication bias, a pooled analysis of 83% (10/12) of the trials and 86% (12/14) of the interventions showed that app-based interventions, compared with a control group receiving usual care or minimal intervention, produced a moderate reduction in depressive symptoms (standardized mean difference [SMD] -0.51, 95% CI -0.69 to -0.33; 2018/2859, 70.58% of the participants; I(2)=70%). Our meta-regression analyses indicated that there was a greater reduction in symptoms of depression (P=.04) in trials that included participants with moderate to severe depression (SMD -0.67, 95% CI -0.79 to -0.55), compared with trials with participants exhibiting mild to moderate depression (SMD -0.15, 95% CI -0.43 to -0.12). CONCLUSIONS: App-based interventions targeted at people with depression produce moderate reductions in the symptoms of depression. More methodologically robust trials are needed to confirm our findings, determine which intervention features are associated with greater improvements, and identify those populations most likely to benefit from this type of intervention. TRIAL REGISTRATION: PROSPERO CRD42019145689; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=145689.
  

• 
  1.

  Lugones-Sánchez C, Recio-Rodríguez JI, Menéndez-Suárez M, Saz-Lara A, Ramirez-Manent JI, Sánchez-Calavera MA, Gómez-Sánchez L, Rodríguez-Sánchez E, García-Ortiz L, Evident Investigators G. Effect of a Multicomponent mHealth Intervention on the Composition of Diet in a Population with Overweight and ObesitytextemdashRandomized Clinical Trial EVIDENT 3. Nutrients [Internet]. MDPI AG; 2022 Jan.;14(2):270. https://doi.org/10.3390%2Fnu14020270

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  A balanced diet can help in the prevention of chronic diseases. The aim of this study was to evaluate the effect of an mHealth intervention on the distribution of macronutrients and the intake of food groups. A total of 650 participants were included in this multi-center, clinical, randomized, controlled trial (Evident 3 study). All participants were given brief advice about diet and exercise. The intervention group received, in addition, an app (Evident 3) for the self-recording of their diet and an activity tracker wristband for 3 months. Follow-up visits were performed at 3 and 12 months to collect the diet composition using the Food Frequency Questionnaire. There were decreases in the intake of total calories, fat, protein and carbohydrates in both groups throughout the study, without significant differences between them. The intervention group reduced the intake of cholesterol (−30.8; 95% CI −59.9, −1.7) and full-fat dairies (−23.3; 95% CI −42.8, −3.8) and increased the intake of wholemeal bread (3.3; 95% CI −6.7, 13.3) and whole-grain cereals (3.4; 95% CI −6.8, 13.7) with respect to the control group. No differences were found in the rest of the nutritional parameters. The brief advice is useful to promote a healthier diet, and the app can be a support tool to obtain changes in relevant foods, such as integral foods, and the intake of cholesterol. Trial registration: ClinicalTrials.gov with identifier NCT03175614

  @article{Lugones_S_nchez_2022,
  abstract = {A balanced diet can help in the prevention of chronic diseases. The aim of this study was to evaluate the effect of an mHealth intervention on the distribution of macronutrients and the intake of food groups. A total of 650 participants were included in this multi-center, clinical, randomized, controlled trial (Evident 3 study). All participants were given brief advice about diet and exercise. The intervention group received, in addition, an app (Evident 3) for the self-recording of their diet and an activity tracker wristband for 3 months. Follow-up visits were performed at 3 and 12 months to collect the diet composition using the Food Frequency Questionnaire. There were decreases in the intake of total calories, fat, protein and carbohydrates in both groups throughout the study, without significant differences between them. The intervention group reduced the intake of cholesterol (−30.8; 95% CI −59.9, −1.7) and full-fat dairies (−23.3; 95% CI −42.8, −3.8) and increased the intake of wholemeal bread (3.3; 95% CI −6.7, 13.3) and whole-grain cereals (3.4; 95% CI −6.8, 13.7) with respect to the control group. No differences were found in the rest of the nutritional parameters. The brief advice is useful to promote a healthier diet, and the app can be a support tool to obtain changes in relevant foods, such as integral foods, and the intake of cholesterol. Trial registration: ClinicalTrials.gov with identifier NCT03175614},
  author = {Lugones-Sánchez, C. and Recio-Rodríguez, J. I. and Menéndez-Suárez, M. and Saz-Lara, A. and Ramirez-Manent, J. I. and Sánchez-Calavera, M. A. and Gómez-Sánchez, L. and Rodríguez-Sánchez, E. and García-Ortiz, L. and Evident Investigators, Group},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {jan},
  number = 2,
  pages = 270,
  publisher = {MDPI AG},
  title = {Effect of a Multicomponent mHealth Intervention on the Composition of Diet in a Population with Overweight and ObesitytextemdashRandomized Clinical Trial EVIDENT 3},
  volume = 14,
  year = 2022
  }
  

  %0 Journal Article
  %1 Lugones_S_nchez_2022
  %A Lugones-Sánchez, C.
  %A Recio-Rodríguez, J. I.
  %A Menéndez-Suárez, M.
  %A Saz-Lara, A.
  %A Ramirez-Manent, J. I.
  %A Sánchez-Calavera, M. A.
  %A Gómez-Sánchez, L.
  %A Rodríguez-Sánchez, E.
  %A García-Ortiz, L.
  %A Evident Investigators, Group
  %D 2022
  %I MDPI AG
  %J Nutrients
  %N 2
  %P 270
  %R 10.3390/nu14020270
  %T Effect of a Multicomponent mHealth Intervention on the Composition of Diet in a Population with Overweight and ObesitytextemdashRandomized Clinical Trial EVIDENT 3
  %U https://doi.org/10.3390%2Fnu14020270
  %V 14
  %X A balanced diet can help in the prevention of chronic diseases. The aim of this study was to evaluate the effect of an mHealth intervention on the distribution of macronutrients and the intake of food groups. A total of 650 participants were included in this multi-center, clinical, randomized, controlled trial (Evident 3 study). All participants were given brief advice about diet and exercise. The intervention group received, in addition, an app (Evident 3) for the self-recording of their diet and an activity tracker wristband for 3 months. Follow-up visits were performed at 3 and 12 months to collect the diet composition using the Food Frequency Questionnaire. There were decreases in the intake of total calories, fat, protein and carbohydrates in both groups throughout the study, without significant differences between them. The intervention group reduced the intake of cholesterol (−30.8; 95% CI −59.9, −1.7) and full-fat dairies (−23.3; 95% CI −42.8, −3.8) and increased the intake of wholemeal bread (3.3; 95% CI −6.7, 13.3) and whole-grain cereals (3.4; 95% CI −6.8, 13.7) with respect to the control group. No differences were found in the rest of the nutritional parameters. The brief advice is useful to promote a healthier diet, and the app can be a support tool to obtain changes in relevant foods, such as integral foods, and the intake of cholesterol. Trial registration: ClinicalTrials.gov with identifier NCT03175614
  

• 
  1.

  Galmes-Panades AM, Abbate M, Bennasar-Veny M, López-González AA, Vicente-Herrero MT, Busquets-Cortés C, Leiva A, Yañez AM. Occupational and Leisure Physical Activity on Cardiovascular Risk and Body Composition Among Courier Workers. Biol Res Nurs. 2022;:10998004221105535.

  AbstractBibTeXEndNoteDOIBibSonomy

  OBJECTIVE: There is some controversy about the beneficial effects of occupational physical activity (OPA) on cardiovascular risk (CVR). The main aim of this study was to explore the effect of the combination of different frequencies of leisure-time physical activity (LTPA) and two types of OPA on CVR and body composition, and whether the association between physical activity (PA) and CVR was mediated by visceral adipose tissue (VAT). METHODS: This cross-sectional study included data from 2516 couriers living in Spain, delivering either by motorbike or foot, and practicing LTPA never, occasionally, or regularly. Couriers were classified into six categories according to LTPA and OPA; body composition was assessed by Bioelectrical Impedance, and CVR by the Framingham equation. General linear models were performed to explore the association between different categories with each outcome (CVR and body composition) and the possible role of VAT as a mediator between PA and CVR. RESULTS: Compared with the most sedentary group (motorbike couriers that never practice PA), walking couriers who practice regular PA presented the lowest CVR [β -1.58 (95% CI -2.31; -0.85)] and the lowest VAT [β -2.86 (95% CI -3.74; -1.98) followed by the motorbike couriers who practiced regular PA [β -0.51 (95% CI -1.00; -0.03) for CVR and β -2.33 (95% CI -2.91; -1.75) for VAT]. The association between PA and CVR was partially mediated by VAT. CONCLUSION: The present results indicated that both OPA and LTPA are protective factors for CVR and play an important role on VAT accumulation.

  @article{RN190,
  abstract = {OBJECTIVE: There is some controversy about the beneficial effects of occupational physical activity (OPA) on cardiovascular risk (CVR). The main aim of this study was to explore the effect of the combination of different frequencies of leisure-time physical activity (LTPA) and two types of OPA on CVR and body composition, and whether the association between physical activity (PA) and CVR was mediated by visceral adipose tissue (VAT). METHODS: This cross-sectional study included data from 2516 couriers living in Spain, delivering either by motorbike or foot, and practicing LTPA never, occasionally, or regularly. Couriers were classified into six categories according to LTPA and OPA; body composition was assessed by Bioelectrical Impedance, and CVR by the Framingham equation. General linear models were performed to explore the association between different categories with each outcome (CVR and body composition) and the possible role of VAT as a mediator between PA and CVR. RESULTS: Compared with the most sedentary group (motorbike couriers that never practice PA), walking couriers who practice regular PA presented the lowest CVR [β -1.58 (95% CI -2.31; -0.85)] and the lowest VAT [β -2.86 (95% CI -3.74; -1.98) followed by the motorbike couriers who practiced regular PA [β -0.51 (95% CI -1.00; -0.03) for CVR and β -2.33 (95% CI -2.91; -1.75) for VAT]. The association between PA and CVR was partially mediated by VAT. CONCLUSION: The present results indicated that both OPA and LTPA are protective factors for CVR and play an important role on VAT accumulation.},
  author = {Galmes-Panades, A. M. and Abbate, M. and Bennasar-Veny, M. and López-González, A. A. and Vicente-Herrero, M. T. and Busquets-Cortés, C. and Leiva, A. and Yañez, A. M.},
  journal = {Biol Res Nurs},
  keywords = {grapp-caib},
  pages = 10998004221105535,
  title = {Occupational and Leisure Physical Activity on Cardiovascular Risk and Body Composition Among Courier Workers},
  type = {Journal Article},
  year = 2022
  }
  

  %0 Journal Article
  %1 RN190
  %A Galmes-Panades, A. M.
  %A Abbate, M.
  %A Bennasar-Veny, M.
  %A López-González, A. A.
  %A Vicente-Herrero, M. T.
  %A Busquets-Cortés, C.
  %A Leiva, A.
  %A Yañez, A. M.
  %D 2022
  %J Biol Res Nurs
  %P 10998004221105535
  %R 10.1177/10998004221105535
  %T Occupational and Leisure Physical Activity on Cardiovascular Risk and Body Composition Among Courier Workers
  %X OBJECTIVE: There is some controversy about the beneficial effects of occupational physical activity (OPA) on cardiovascular risk (CVR). The main aim of this study was to explore the effect of the combination of different frequencies of leisure-time physical activity (LTPA) and two types of OPA on CVR and body composition, and whether the association between physical activity (PA) and CVR was mediated by visceral adipose tissue (VAT). METHODS: This cross-sectional study included data from 2516 couriers living in Spain, delivering either by motorbike or foot, and practicing LTPA never, occasionally, or regularly. Couriers were classified into six categories according to LTPA and OPA; body composition was assessed by Bioelectrical Impedance, and CVR by the Framingham equation. General linear models were performed to explore the association between different categories with each outcome (CVR and body composition) and the possible role of VAT as a mediator between PA and CVR. RESULTS: Compared with the most sedentary group (motorbike couriers that never practice PA), walking couriers who practice regular PA presented the lowest CVR [β -1.58 (95% CI -2.31; -0.85)] and the lowest VAT [β -2.86 (95% CI -3.74; -1.98) followed by the motorbike couriers who practiced regular PA [β -0.51 (95% CI -1.00; -0.03) for CVR and β -2.33 (95% CI -2.91; -1.75) for VAT]. The association between PA and CVR was partially mediated by VAT. CONCLUSION: The present results indicated that both OPA and LTPA are protective factors for CVR and play an important role on VAT accumulation.
  

• 
  1.

  Zamanillo-Campos R, Serrano-Ripoll MJ, Taltavull-Aparicio JM, Gervilla-Garc’ia E, Ripoll J, Fiol deRoque MA, Boylan A-M, Ricci-Cabello I. Patients’ Views on the Design of DiabeText, a New mHealth Intervention to Improve Adherence to Oral Antidiabetes Medication in Spain: A Qualitative Study. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2022 Feb.;19(3):1902. https://doi.org/10.3390%2Fijerph19031902

  URLBibTeXEndNoteDOIBibSonomyDownload

  @article{Zamanillo_Campos_2022,
  author = {Zamanillo-Campos, Rocío and Serrano-Ripoll, Maria Jesús and Taltavull-Aparicio, Joana Maria and Gervilla-Garc'ia, Elena and Ripoll, Joana and Fiol deRoque, Maria Antonia and Boylan, Anne-Marie and Ricci-Cabello, Ignacio},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {feb},
  number = 3,
  pages = 1902,
  publisher = {MDPI AG},
  title = {Patients' Views on the Design of DiabeText, a New mHealth Intervention to Improve Adherence to Oral Antidiabetes Medication in Spain: A Qualitative Study},
  volume = 19,
  year = 2022
  }
  

  %0 Journal Article
  %1 Zamanillo_Campos_2022
  %A Zamanillo-Campos, Rocío
  %A Serrano-Ripoll, Maria Jesús
  %A Taltavull-Aparicio, Joana Maria
  %A Gervilla-Garc'ia, Elena
  %A Ripoll, Joana
  %A Fiol deRoque, Maria Antonia
  %A Boylan, Anne-Marie
  %A Ricci-Cabello, Ignacio
  %D 2022
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 3
  %P 1902
  %R 10.3390/ijerph19031902
  %T Patients' Views on the Design of DiabeText, a New mHealth Intervention to Improve Adherence to Oral Antidiabetes Medication in Spain: A Qualitative Study
  %U https://doi.org/10.3390%2Fijerph19031902
  %V 19
  

• 
  1.

  Zamanillo-Campos R, Serrano-Ripoll MJ, Taltavull-Aparicio JM, Gervilla-Garc’ia E, Ripoll J, Fiol deRoque MA, Boylan A-M, Ricci-Cabello I. Perspectives and Views of Primary Care Professionals Regarding DiabeText, a New mHealth Intervention to Support Adherence to Antidiabetic Medication in Spain: A Qualitative Study. SDFSDF, editor. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2022 Apr.;19(7):4237. https://doi.org/10.3390%2Fijerph19074237

  URLBibTeXEndNoteDOIBibSonomyDownload

  @article{Zamanillo_Campos_2022,
  author = {Zamanillo-Campos, Rocío and Serrano-Ripoll, Maria Jesús and Taltavull-Aparicio, Joana Maria and Gervilla-Garc'ia, Elena and Ripoll, Joana and Fiol deRoque, Maria Antonia and Boylan, Anne-Marie and Ricci-Cabello, Ignacio},
  editor = {SDFSDF},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {myown},
  month = {apr},
  number = 7,
  pages = 4237,
  publisher = {MDPI AG},
  title = {Perspectives and Views of Primary Care Professionals Regarding DiabeText, a New mHealth Intervention to Support Adherence to Antidiabetic Medication in Spain: A Qualitative Study},
  volume = 19,
  year = 2022
  }
  

  %0 Journal Article
  %1 Zamanillo_Campos_2022
  %A Zamanillo-Campos, Rocío
  %A Serrano-Ripoll, Maria Jesús
  %A Taltavull-Aparicio, Joana Maria
  %A Gervilla-Garc'ia, Elena
  %A Ripoll, Joana
  %A Fiol deRoque, Maria Antonia
  %A Boylan, Anne-Marie
  %A Ricci-Cabello, Ignacio
  %D 2022
  %E SDFSDF,
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 7
  %P 4237
  %R 10.3390/ijerph19074237
  %T Perspectives and Views of Primary Care Professionals Regarding DiabeText, a New mHealth Intervention to Support Adherence to Antidiabetic Medication in Spain: A Qualitative Study
  %U https://doi.org/10.3390%2Fijerph19074237
  %V 19
  

• 
  1.

  Sánchez Rodríguez C, Bulilete O, Chela-Alvarez X, Velasco-Roldán O, Llobera-Canaves J. Chronic Pain and Work Conditions of Hotel Housekeepers: A Descriptive Study. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2022 Mar.;19(6):3383. https://doi.org/10.3390%2Fijerph19063383

  URLBibTeXEndNoteDOIBibSonomyDownload

  @article{S_nchez_Rodr_guez_2022,
  author = {Sánchez Rodríguez, Cristian and Bulilete, Oana and Chela-Alvarez, Xenia and Velasco-Roldán, Olga and Llobera-Canaves, Joan},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {mar},
  number = 6,
  pages = 3383,
  publisher = {MDPI AG},
  title = {Chronic Pain and Work Conditions of Hotel Housekeepers: A Descriptive Study},
  volume = 19,
  year = 2022
  }
  

  %0 Journal Article
  %1 S_nchez_Rodr_guez_2022
  %A Sánchez Rodríguez, Cristian
  %A Bulilete, Oana
  %A Chela-Alvarez, Xenia
  %A Velasco-Roldán, Olga
  %A Llobera-Canaves, Joan
  %D 2022
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 6
  %P 3383
  %R 10.3390/ijerph19063383
  %T Chronic Pain and Work Conditions of Hotel Housekeepers: A Descriptive Study
  %U https://doi.org/10.3390%2Fijerph19063383
  %V 19
  

• 
  1.

  Manent JIR, Jané BA, Cortés PS, Busquets-Cortés C, Bote SA, Comas LM, González Ángel AL. Impact of COVID-19 Lockdown on Anthropometric Variables, Blood Pressure, and Glucose and Lipid Profile in Healthy Adults: A before and after Pandemic Lockdown Longitudinal Study. Nutrients [Internet]. MDPI AG; 2022 Mar.;14(6):1237. https://doi.org/10.3390%2Fnu14061237

  URLBibTeXEndNoteDOIBibSonomyDownload

  @article{Ram_rez_Manent_2022,
  author = {Manent, José Ignacio Ram'irez and Jané, Bárbara Altisench and Cortés, Pilar Sanch'is and Busquets-Cortés, Carla and Bote, Sebastiana Arroyo and Comas, Luis Masmiquel and González, Ángel Arturo López},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {mar},
  number = 6,
  pages = 1237,
  publisher = {MDPI AG},
  title = {Impact of COVID-19 Lockdown on Anthropometric Variables, Blood Pressure, and Glucose and Lipid Profile in Healthy Adults: A before and after Pandemic Lockdown Longitudinal Study},
  volume = 14,
  year = 2022
  }
  

  %0 Journal Article
  %1 Ram_rez_Manent_2022
  %A Manent, José Ignacio Ram'irez
  %A Jané, Bárbara Altisench
  %A Cortés, Pilar Sanch'is
  %A Busquets-Cortés, Carla
  %A Bote, Sebastiana Arroyo
  %A Comas, Luis Masmiquel
  %A González, Ángel Arturo López
  %D 2022
  %I MDPI AG
  %J Nutrients
  %N 6
  %P 1237
  %R 10.3390/nu14061237
  %T Impact of COVID-19 Lockdown on Anthropometric Variables, Blood Pressure, and Glucose and Lipid Profile in Healthy Adults: A before and after Pandemic Lockdown Longitudinal Study
  %U https://doi.org/10.3390%2Fnu14061237
  %V 14
  

• 
  1.

  Aguilar-Latorre A, Serrano-Ripoll MJ, Oliván-Blázquez B, Gervilla E, Navarro C. Associations Between Severity of Depression, Lifestyle Patterns, and Personal Factors Related to Health Behavior: Secondary Data Analysis From a Randomized Controlled Trial. Frontiers in Psychology [Internet]. Frontiers Media SA; 2022 Mar.;13. https://doi.org/10.3389%2Ffpsyg.2022.856139

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Depression is a prevalent condition that has a significant impact on psychosocial functioning and quality of life. The onset and persistence of depression have been linked to a variety of biological and psychosocial variables. Many of these variables are associated with specific lifestyle characteristics, such as physical activity, diet, and sleep patterns. Some psychosocial determinants have an impact on people' health-related behavior change. These include personal factors such as sense of coherence, patient activation, health literacy, self-efficacy, and procrastination. This study aims to analyze the association between the severity of depression, lifestyle patterns, and personal factors related to health behavior. It also aims to analyze whether personal factors moderate the relationship between lifestyles and depression. METHODS: This study is a secondary data analysis (SDA) of baseline data collected at the start of a randomized controlled trial (RCT). A sample of 226 patients with subclinical, mild, or moderate depression from primary healthcare centers in two sites in Spain (Zaragoza and Mallorca) was used, and descriptive, bivariate, multivariate, and moderation analyses were performed. Depression was the primary outcome, measured by Beck II Self-Applied Depression Inventory. Lifestyle variables such as physical exercise, adherence to Mediterranean diet and sleep quality, social support, and personal factors such as self-efficacy, patient activation in their own health, sense of coherence, health literacy, and procrastination were considered secondary outcomes. RESULTS: Low sense of coherence (β = -0.172; p < 0.001), poor sleep quality (β = 0.179; p = 0.008), low patient activation (β = -0.119; p = 0.019), and sedentarism (more minutes seated per day; β = 0.003; p = 0.025) are predictors of having more depressive symptoms. Moderation analyses were not significant. DISCUSSION: Lifestyle and personal factors are related to depressive symptomatology. Our findings reveal that sense of coherence, patient's activation level, sedentarism, and sleep quality are associated with depression. Further research is needed regarding adherence to Mediterranean diet, minutes walking per week and the interrelationship between lifestyles, personal factors, and depression.

  @article{Aguilar_Latorre_2022,
  abstract = {BACKGROUND: Depression is a prevalent condition that has a significant impact on psychosocial functioning and quality of life. The onset and persistence of depression have been linked to a variety of biological and psychosocial variables. Many of these variables are associated with specific lifestyle characteristics, such as physical activity, diet, and sleep patterns. Some psychosocial determinants have an impact on people' health-related behavior change. These include personal factors such as sense of coherence, patient activation, health literacy, self-efficacy, and procrastination. This study aims to analyze the association between the severity of depression, lifestyle patterns, and personal factors related to health behavior. It also aims to analyze whether personal factors moderate the relationship between lifestyles and depression. METHODS: This study is a secondary data analysis (SDA) of baseline data collected at the start of a randomized controlled trial (RCT). A sample of 226 patients with subclinical, mild, or moderate depression from primary healthcare centers in two sites in Spain (Zaragoza and Mallorca) was used, and descriptive, bivariate, multivariate, and moderation analyses were performed. Depression was the primary outcome, measured by Beck II Self-Applied Depression Inventory. Lifestyle variables such as physical exercise, adherence to Mediterranean diet and sleep quality, social support, and personal factors such as self-efficacy, patient activation in their own health, sense of coherence, health literacy, and procrastination were considered secondary outcomes. RESULTS: Low sense of coherence (β = -0.172; p < 0.001), poor sleep quality (β = 0.179; p = 0.008), low patient activation (β = -0.119; p = 0.019), and sedentarism (more minutes seated per day; β = 0.003; p = 0.025) are predictors of having more depressive symptoms. Moderation analyses were not significant. DISCUSSION: Lifestyle and personal factors are related to depressive symptomatology. Our findings reveal that sense of coherence, patient's activation level, sedentarism, and sleep quality are associated with depression. Further research is needed regarding adherence to Mediterranean diet, minutes walking per week and the interrelationship between lifestyles, personal factors, and depression.},
  author = {Aguilar-Latorre, Alejandra and Serrano-Ripoll, Maria J. and Oliván-Blázquez, Bárbara and Gervilla, Elena and Navarro, Capilla},
  journal = {Frontiers in Psychology},
  keywords = {grapp-caib},
  month = {mar},
  publisher = {Frontiers Media SA},
  title = {Associations Between Severity of Depression, Lifestyle Patterns, and Personal Factors Related to Health Behavior: Secondary Data Analysis From a Randomized Controlled Trial},
  volume = 13,
  year = 2022
  }
  

  %0 Journal Article
  %1 Aguilar_Latorre_2022
  %A Aguilar-Latorre, Alejandra
  %A Serrano-Ripoll, Maria J.
  %A Oliván-Blázquez, Bárbara
  %A Gervilla, Elena
  %A Navarro, Capilla
  %D 2022
  %I Frontiers Media SA
  %J Frontiers in Psychology
  %R 10.3389/fpsyg.2022.856139
  %T Associations Between Severity of Depression, Lifestyle Patterns, and Personal Factors Related to Health Behavior: Secondary Data Analysis From a Randomized Controlled Trial
  %U https://doi.org/10.3389%2Ffpsyg.2022.856139
  %V 13
  %X BACKGROUND: Depression is a prevalent condition that has a significant impact on psychosocial functioning and quality of life. The onset and persistence of depression have been linked to a variety of biological and psychosocial variables. Many of these variables are associated with specific lifestyle characteristics, such as physical activity, diet, and sleep patterns. Some psychosocial determinants have an impact on people' health-related behavior change. These include personal factors such as sense of coherence, patient activation, health literacy, self-efficacy, and procrastination. This study aims to analyze the association between the severity of depression, lifestyle patterns, and personal factors related to health behavior. It also aims to analyze whether personal factors moderate the relationship between lifestyles and depression. METHODS: This study is a secondary data analysis (SDA) of baseline data collected at the start of a randomized controlled trial (RCT). A sample of 226 patients with subclinical, mild, or moderate depression from primary healthcare centers in two sites in Spain (Zaragoza and Mallorca) was used, and descriptive, bivariate, multivariate, and moderation analyses were performed. Depression was the primary outcome, measured by Beck II Self-Applied Depression Inventory. Lifestyle variables such as physical exercise, adherence to Mediterranean diet and sleep quality, social support, and personal factors such as self-efficacy, patient activation in their own health, sense of coherence, health literacy, and procrastination were considered secondary outcomes. RESULTS: Low sense of coherence (β = -0.172; p < 0.001), poor sleep quality (β = 0.179; p = 0.008), low patient activation (β = -0.119; p = 0.019), and sedentarism (more minutes seated per day; β = 0.003; p = 0.025) are predictors of having more depressive symptoms. Moderation analyses were not significant. DISCUSSION: Lifestyle and personal factors are related to depressive symptomatology. Our findings reveal that sense of coherence, patient's activation level, sedentarism, and sleep quality are associated with depression. Further research is needed regarding adherence to Mediterranean diet, minutes walking per week and the interrelationship between lifestyles, personal factors, and depression.
  

• 
  1.

  Juan-Clar M, Torrent M, Santandreu P, Arejola E, Ibarra J, Tubau A. Effectiveness of Ultrasound Screening for a Placenta Accreta Spectrum Using Standard Ultrasound Criteria in a Secondary Care Setting. Fetal Diagnosis and Therapy [Internet]. 2022;49(1):52-9. https://www.karger.com/DOI/10.1159/000521738

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Objectives: Ultrasound detection of a placenta accreta spectrum (PAS) among women at risk is a key goal to reduce obstetric morbidity, but there is scarce information on its performance in real clinical settings. We report the effectiveness of a standardized ultrasound protocol to detect PAS in women with placenta previa (PP) in a secondary-level hospital. Methods: A retrospective analysis, including a cohort of 126 women with persistent PP among 27,975 pregnancies between 2008 and 2020, was performed. All 126 women underwent standardized transabdominal and transvaginal ultrasound scan that assessed 5 criteria: (1) loss of hypoechoic retroplacental zone and/or myometrial thinning <1 mm; (2) lacunar images with a flow of >15 cm/s; (3) thick and bulging placenta; (4) thinning or interruption of the uterine-bladder serous interface; and (5) placental or uterovesical hypervascularity. The presence of at least one criterion was considered a high risk for PAS. Diagnosis of PAS was confirmed during the caesarean section and by histopathological analysis. Results: Among 126 women with PP, 11 (8.7%) cases of PAS were diagnosed, of which 10 were detected prenatally by ultrasound scan. This resulted in a sensitivity of 90.9%, a specificity of 98.3%, a positive predictive value of 83.3%, and a negative predictive value of 99.1%. Histopathological assessment showed 6 placenta increta (54.5%), 4 percreta (36.4%), and 1 accreta (9.1%). All 10 cases of invasive placenta presented more than 3 ultrasound criteria. Conclusions: Standardized ultrasound screening protocol in women at risk due to PP in the third trimester was highly effective in detecting PAS in a secondary-level hospital setting.

  @article{juanclar2022effectiveness,
  abstract = {Objectives: Ultrasound detection of a placenta accreta spectrum (PAS) among women at risk is a key goal to reduce obstetric morbidity, but there is scarce information on its performance in real clinical settings. We report the effectiveness of a standardized ultrasound protocol to detect PAS in women with placenta previa (PP) in a secondary-level hospital. Methods: A retrospective analysis, including a cohort of 126 women with persistent PP among 27,975 pregnancies between 2008 and 2020, was performed. All 126 women underwent standardized transabdominal and transvaginal ultrasound scan that assessed 5 criteria: (1) loss of hypoechoic retroplacental zone and/or myometrial thinning <1 mm; (2) lacunar images with a flow of >15 cm/s; (3) thick and bulging placenta; (4) thinning or interruption of the uterine-bladder serous interface; and (5) placental or uterovesical hypervascularity. The presence of at least one criterion was considered a high risk for PAS. Diagnosis of PAS was confirmed during the caesarean section and by histopathological analysis. Results: Among 126 women with PP, 11 (8.7%) cases of PAS were diagnosed, of which 10 were detected prenatally by ultrasound scan. This resulted in a sensitivity of 90.9%, a specificity of 98.3%, a positive predictive value of 83.3%, and a negative predictive value of 99.1%. Histopathological assessment showed 6 placenta increta (54.5%), 4 percreta (36.4%), and 1 accreta (9.1%). All 10 cases of invasive placenta presented more than 3 ultrasound criteria. Conclusions: Standardized ultrasound screening protocol in women at risk due to PP in the third trimester was highly effective in detecting PAS in a secondary-level hospital setting.},
  author = {Juan-Clar, M. and Torrent, M. and Santandreu, P. and Arejola, E. and Ibarra, J. and Tubau, A.},
  journal = {Fetal Diagnosis and Therapy},
  keywords = {grapp-caib},
  number = 1,
  pages = {52--59},
  title = {Effectiveness of Ultrasound Screening for a Placenta Accreta Spectrum Using Standard Ultrasound Criteria in a Secondary Care Setting},
  volume = 49,
  year = 2022
  }
  

  %0 Journal Article
  %1 juanclar2022effectiveness
  %A Juan-Clar, M.
  %A Torrent, M.
  %A Santandreu, P.
  %A Arejola, E.
  %A Ibarra, J.
  %A Tubau, A.
  %D 2022
  %J Fetal Diagnosis and Therapy
  %N 1
  %P 52--59
  %R 10.1159/000521738
  %T Effectiveness of Ultrasound Screening for a Placenta Accreta Spectrum Using Standard Ultrasound Criteria in a Secondary Care Setting
  %U https://www.karger.com/DOI/10.1159/000521738
  %V 49
  %X Objectives: Ultrasound detection of a placenta accreta spectrum (PAS) among women at risk is a key goal to reduce obstetric morbidity, but there is scarce information on its performance in real clinical settings. We report the effectiveness of a standardized ultrasound protocol to detect PAS in women with placenta previa (PP) in a secondary-level hospital. Methods: A retrospective analysis, including a cohort of 126 women with persistent PP among 27,975 pregnancies between 2008 and 2020, was performed. All 126 women underwent standardized transabdominal and transvaginal ultrasound scan that assessed 5 criteria: (1) loss of hypoechoic retroplacental zone and/or myometrial thinning <1 mm; (2) lacunar images with a flow of >15 cm/s; (3) thick and bulging placenta; (4) thinning or interruption of the uterine-bladder serous interface; and (5) placental or uterovesical hypervascularity. The presence of at least one criterion was considered a high risk for PAS. Diagnosis of PAS was confirmed during the caesarean section and by histopathological analysis. Results: Among 126 women with PP, 11 (8.7%) cases of PAS were diagnosed, of which 10 were detected prenatally by ultrasound scan. This resulted in a sensitivity of 90.9%, a specificity of 98.3%, a positive predictive value of 83.3%, and a negative predictive value of 99.1%. Histopathological assessment showed 6 placenta increta (54.5%), 4 percreta (36.4%), and 1 accreta (9.1%). All 10 cases of invasive placenta presented more than 3 ultrasound criteria. Conclusions: Standardized ultrasound screening protocol in women at risk due to PP in the third trimester was highly effective in detecting PAS in a secondary-level hospital setting.
  

• 
  1.

  Vicens C, Leiva A, Bejarano F, Sempere-Verdú E, Rodríguez-Rincón RM, Fiol F, Mengual M, Ajenjo-Navarro A, Do Pazo F, Mateu C, Folch S, Alegret S, Coll JM, Martín-Rabadán M, Socias I. Evaluation of a multicomponent intervention consisting of education and feedback to reduce benzodiazepine prescriptions by general practitioners: The BENZORED hybrid type 1 cluster randomized controlled trial. PLOS Medicine [Internet]. Public Library of Science; 2022 May;19(5):1-16. https://doi.org/10.1371/journal.pmed.1003983

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Background Current benzodiazepine (BZD) prescription guidelines recommend short-term use to minimize the risk of dependence, cognitive impairment, and falls and fractures. However, many clinicians overprescribe BZDs and chronic use by patients is common. There is limited evidence on the effectiveness of interventions delivered by general practitioners (GPs) on reducing prescriptions and long-term use of BZDs. We aimed to evaluate the effectiveness of a multicomponent intervention for GPs that seeks to reduce BZD prescriptions and the prevalence of long-term users. Methods and findings We conducted a multicenter two-arm, cluster randomized controlled trial in 3 health districts in Spain (primary health centers [PHCs] in Balearic Islands, Catalonia, and Valencian Community) from September 2016 to May 2018. The 81 PHCs were randomly allocated to the intervention group (n = 41; 372 GPs) or the control group (n = 40; 377 GPs). GPs were not blinded to the allocation; however, pharmacists, researchers, and trial statisticians were blinded to the allocation arm. The intervention consisted of a workshop about the appropriate prescribing of BZDs and tapering-off long-term BZD use using a tailored stepped dose reduction with monthly BZD prescription feedback and access to a support web page. The primary outcome, based on 700 GPs (351 in the control group and 349 in the intervention group), compared changes in BZD prescriptions in defined daily doses (DDDs) per 1,000 inhabitants per day after 12 months. The 2 secondary outcomes were the proportion of long-term users (≥6 months) and the proportion of long-term users over age 65 years. Intention-to-treat (ITT) analysis was used to assess all clinical outcomes. Forty-nine GPs (21 intervention group and 28 control group) were lost to follow-up. However, all GPs were included in the ITT analysis. After 12 months, there were a statistically significant decline in total BZD prescription in the intervention group compared to the control group (mean difference: −3.24 DDDs per 1,000 inhabitants per day, 95% confidence interval (CI): −4.96, −1.53, p < 0.001). The intervention group also had a smaller number of long-term users. The adjusted absolute difference overall was −0.36 (95% CI: −0.55, −0.16, p > 0.001), and the adjusted absolute difference in long-term users over age 65 years was −0.87 (95% CI: −1.44, −0.30, p = 0.003). A key limitation of this clustered design clinical trial is the imbalance of some baseline characteristics. The control groups have a higher rate of baseline BZD prescription, and more GPs in the intervention group were women, GPs with a doctorate degree, and trainers of GP residents. Conclusions A multicomponent intervention that targeted GPs and included educational meeting, feedback about BZD prescriptions, and a support web page led to a statistically significant reduction of BZD prescriptions and fewer long-term users. Although the effect size was small, the high prevalence of BZD use in the general population suggests that large-scale implementation of this intervention could have positive effects on the health of many patients. Trial registration ISRCTN ISRCTN28272199.

  @article{10.1371/journal.pmed.1003983,
  abstract = {Background Current benzodiazepine (BZD) prescription guidelines recommend short-term use to minimize the risk of dependence, cognitive impairment, and falls and fractures. However, many clinicians overprescribe BZDs and chronic use by patients is common. There is limited evidence on the effectiveness of interventions delivered by general practitioners (GPs) on reducing prescriptions and long-term use of BZDs. We aimed to evaluate the effectiveness of a multicomponent intervention for GPs that seeks to reduce BZD prescriptions and the prevalence of long-term users. Methods and findings We conducted a multicenter two-arm, cluster randomized controlled trial in 3 health districts in Spain (primary health centers [PHCs] in Balearic Islands, Catalonia, and Valencian Community) from September 2016 to May 2018. The 81 PHCs were randomly allocated to the intervention group (n = 41; 372 GPs) or the control group (n = 40; 377 GPs). GPs were not blinded to the allocation; however, pharmacists, researchers, and trial statisticians were blinded to the allocation arm. The intervention consisted of a workshop about the appropriate prescribing of BZDs and tapering-off long-term BZD use using a tailored stepped dose reduction with monthly BZD prescription feedback and access to a support web page. The primary outcome, based on 700 GPs (351 in the control group and 349 in the intervention group), compared changes in BZD prescriptions in defined daily doses (DDDs) per 1,000 inhabitants per day after 12 months. The 2 secondary outcomes were the proportion of long-term users (≥6 months) and the proportion of long-term users over age 65 years. Intention-to-treat (ITT) analysis was used to assess all clinical outcomes. Forty-nine GPs (21 intervention group and 28 control group) were lost to follow-up. However, all GPs were included in the ITT analysis. After 12 months, there were a statistically significant decline in total BZD prescription in the intervention group compared to the control group (mean difference: −3.24 DDDs per 1,000 inhabitants per day, 95% confidence interval (CI): −4.96, −1.53, p < 0.001). The intervention group also had a smaller number of long-term users. The adjusted absolute difference overall was −0.36 (95% CI: −0.55, −0.16, p > 0.001), and the adjusted absolute difference in long-term users over age 65 years was −0.87 (95% CI: −1.44, −0.30, p = 0.003). A key limitation of this clustered design clinical trial is the imbalance of some baseline characteristics. The control groups have a higher rate of baseline BZD prescription, and more GPs in the intervention group were women, GPs with a doctorate degree, and trainers of GP residents. Conclusions A multicomponent intervention that targeted GPs and included educational meeting, feedback about BZD prescriptions, and a support web page led to a statistically significant reduction of BZD prescriptions and fewer long-term users. Although the effect size was small, the high prevalence of BZD use in the general population suggests that large-scale implementation of this intervention could have positive effects on the health of many patients. Trial registration ISRCTN ISRCTN28272199.},
  author = {Vicens, Caterina and Leiva, Alfonso and Bejarano, Ferran and Sempere-Verdú, Ermengol and Rodríguez-Rincón, Raquel María and Fiol, Francisca and Mengual, Marta and Ajenjo-Navarro, Asunción and Do Pazo, Fernando and Mateu, Catalina and Folch, Silvia and Alegret, Santiago and Coll, Jose Maria and Martín-Rabadán, María and Socias, Isabel},
  journal = {PLOS Medicine},
  keywords = {grapp-caib},
  month = {05},
  number = 5,
  pages = {1-16},
  publisher = {Public Library of Science},
  title = {Evaluation of a multicomponent intervention consisting of education and feedback to reduce benzodiazepine prescriptions by general practitioners: The BENZORED hybrid type 1 cluster randomized controlled trial},
  volume = 19,
  year = 2022
  }
  

  %0 Journal Article
  %1 10.1371/journal.pmed.1003983
  %A Vicens, Caterina
  %A Leiva, Alfonso
  %A Bejarano, Ferran
  %A Sempere-Verdú, Ermengol
  %A Rodríguez-Rincón, Raquel María
  %A Fiol, Francisca
  %A Mengual, Marta
  %A Ajenjo-Navarro, Asunción
  %A Do Pazo, Fernando
  %A Mateu, Catalina
  %A Folch, Silvia
  %A Alegret, Santiago
  %A Coll, Jose Maria
  %A Martín-Rabadán, María
  %A Socias, Isabel
  %D 2022
  %I Public Library of Science
  %J PLOS Medicine
  %N 5
  %P 1-16
  %R 10.1371/journal.pmed.1003983
  %T Evaluation of a multicomponent intervention consisting of education and feedback to reduce benzodiazepine prescriptions by general practitioners: The BENZORED hybrid type 1 cluster randomized controlled trial
  %U https://doi.org/10.1371/journal.pmed.1003983
  %V 19
  %X Background Current benzodiazepine (BZD) prescription guidelines recommend short-term use to minimize the risk of dependence, cognitive impairment, and falls and fractures. However, many clinicians overprescribe BZDs and chronic use by patients is common. There is limited evidence on the effectiveness of interventions delivered by general practitioners (GPs) on reducing prescriptions and long-term use of BZDs. We aimed to evaluate the effectiveness of a multicomponent intervention for GPs that seeks to reduce BZD prescriptions and the prevalence of long-term users. Methods and findings We conducted a multicenter two-arm, cluster randomized controlled trial in 3 health districts in Spain (primary health centers [PHCs] in Balearic Islands, Catalonia, and Valencian Community) from September 2016 to May 2018. The 81 PHCs were randomly allocated to the intervention group (n = 41; 372 GPs) or the control group (n = 40; 377 GPs). GPs were not blinded to the allocation; however, pharmacists, researchers, and trial statisticians were blinded to the allocation arm. The intervention consisted of a workshop about the appropriate prescribing of BZDs and tapering-off long-term BZD use using a tailored stepped dose reduction with monthly BZD prescription feedback and access to a support web page. The primary outcome, based on 700 GPs (351 in the control group and 349 in the intervention group), compared changes in BZD prescriptions in defined daily doses (DDDs) per 1,000 inhabitants per day after 12 months. The 2 secondary outcomes were the proportion of long-term users (≥6 months) and the proportion of long-term users over age 65 years. Intention-to-treat (ITT) analysis was used to assess all clinical outcomes. Forty-nine GPs (21 intervention group and 28 control group) were lost to follow-up. However, all GPs were included in the ITT analysis. After 12 months, there were a statistically significant decline in total BZD prescription in the intervention group compared to the control group (mean difference: −3.24 DDDs per 1,000 inhabitants per day, 95% confidence interval (CI): −4.96, −1.53, p < 0.001). The intervention group also had a smaller number of long-term users. The adjusted absolute difference overall was −0.36 (95% CI: −0.55, −0.16, p > 0.001), and the adjusted absolute difference in long-term users over age 65 years was −0.87 (95% CI: −1.44, −0.30, p = 0.003). A key limitation of this clustered design clinical trial is the imbalance of some baseline characteristics. The control groups have a higher rate of baseline BZD prescription, and more GPs in the intervention group were women, GPs with a doctorate degree, and trainers of GP residents. Conclusions A multicomponent intervention that targeted GPs and included educational meeting, feedback about BZD prescriptions, and a support web page led to a statistically significant reduction of BZD prescriptions and fewer long-term users. Although the effect size was small, the high prevalence of BZD use in the general population suggests that large-scale implementation of this intervention could have positive effects on the health of many patients. Trial registration ISRCTN ISRCTN28272199.
  

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  1.

  Zamanillo-Campos R, Coto Alonso L, Fuentes Martín MJ, Nevot Escusa P, Tejón Fernández M. Nutritional counseling for cow’s milk protein allergy in infants from birth to 2 y of ages: Scoping review. Nutrition [Internet]. 2022;98:111633. https://www.sciencedirect.com/science/article/pii/S0899900722000466

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Objectives Cow's milk protein allergy (CMPA) is a clinical condition that requires appropriate nutritional counseling during breastfeeding and the introduction of complementary feeding. Using evidence-based dietetic advice is critical for correct growth and development during childhood. The aim of this study was to review the most recent literature on nutritional counseling aimed at infants between 0 and 2 y of age diagnosed with CMPA. Methods Six databases were searched and updated on August 22, 2020. Retrieved articles were screened in duplicate and independently by all the authors, and these were selected according to the following inclusion criteria: clinical trials, reviews, meta-analyses, and clinical practice guidelines published since 2013 on any dietetic intervention aimed at infant populations between 0 and 2 y of age with CMPA. Critical appraisal through the AGREE instrument and CASP tools enabled the risk of bias assessment. Results We obtained 2874 results, of which 40 were included for reviewing. The retrieved information enabled us to answer all the research questions, including aspects of the nutritional counseling aimed at mothers who breastfeed infants with CMPA, as well as infants during breastfeeding and the introduction of complementary feeding. We also reviewed the specific nutritional requirements of infants with CMPA to assess nutritional supplementation and the evidence available on the use of probiotics, prebiotics, and symbiotics. Conclusions This scoping review collected, in a structured and comprehensive way, the most recent available information regarding nutritional counseling in CMPA for a successful dietetic intervention of the casuistry that may arise during early infancy.

  @article{ZAMANILLOCAMPOS2022111633,
  abstract = {Objectives Cow's milk protein allergy (CMPA) is a clinical condition that requires appropriate nutritional counseling during breastfeeding and the introduction of complementary feeding. Using evidence-based dietetic advice is critical for correct growth and development during childhood. The aim of this study was to review the most recent literature on nutritional counseling aimed at infants between 0 and 2 y of age diagnosed with CMPA. Methods Six databases were searched and updated on August 22, 2020. Retrieved articles were screened in duplicate and independently by all the authors, and these were selected according to the following inclusion criteria: clinical trials, reviews, meta-analyses, and clinical practice guidelines published since 2013 on any dietetic intervention aimed at infant populations between 0 and 2 y of age with CMPA. Critical appraisal through the AGREE instrument and CASP tools enabled the risk of bias assessment. Results We obtained 2874 results, of which 40 were included for reviewing. The retrieved information enabled us to answer all the research questions, including aspects of the nutritional counseling aimed at mothers who breastfeed infants with CMPA, as well as infants during breastfeeding and the introduction of complementary feeding. We also reviewed the specific nutritional requirements of infants with CMPA to assess nutritional supplementation and the evidence available on the use of probiotics, prebiotics, and symbiotics. Conclusions This scoping review collected, in a structured and comprehensive way, the most recent available information regarding nutritional counseling in CMPA for a successful dietetic intervention of the casuistry that may arise during early infancy.},
  author = {Zamanillo-Campos, Rocío and Coto Alonso, Laura and Fuentes Martín, María Jesús and Nevot Escusa, Patricia and Tejón Fernández, Marta},
  journal = {Nutrition},
  keywords = {grapp-caib},
  pages = 111633,
  title = {Nutritional counseling for cow's milk protein allergy in infants from birth to 2 y of ages: Scoping review},
  volume = 98,
  year = 2022
  }
  

  %0 Journal Article
  %1 ZAMANILLOCAMPOS2022111633
  %A Zamanillo-Campos, Rocío
  %A Coto Alonso, Laura
  %A Fuentes Martín, María Jesús
  %A Nevot Escusa, Patricia
  %A Tejón Fernández, Marta
  %D 2022
  %J Nutrition
  %P 111633
  %R https://doi.org/10.1016/j.nut.2022.111633
  %T Nutritional counseling for cow's milk protein allergy in infants from birth to 2 y of ages: Scoping review
  %U https://www.sciencedirect.com/science/article/pii/S0899900722000466
  %V 98
  %X Objectives Cow's milk protein allergy (CMPA) is a clinical condition that requires appropriate nutritional counseling during breastfeeding and the introduction of complementary feeding. Using evidence-based dietetic advice is critical for correct growth and development during childhood. The aim of this study was to review the most recent literature on nutritional counseling aimed at infants between 0 and 2 y of age diagnosed with CMPA. Methods Six databases were searched and updated on August 22, 2020. Retrieved articles were screened in duplicate and independently by all the authors, and these were selected according to the following inclusion criteria: clinical trials, reviews, meta-analyses, and clinical practice guidelines published since 2013 on any dietetic intervention aimed at infant populations between 0 and 2 y of age with CMPA. Critical appraisal through the AGREE instrument and CASP tools enabled the risk of bias assessment. Results We obtained 2874 results, of which 40 were included for reviewing. The retrieved information enabled us to answer all the research questions, including aspects of the nutritional counseling aimed at mothers who breastfeed infants with CMPA, as well as infants during breastfeeding and the introduction of complementary feeding. We also reviewed the specific nutritional requirements of infants with CMPA to assess nutritional supplementation and the evidence available on the use of probiotics, prebiotics, and symbiotics. Conclusions This scoping review collected, in a structured and comprehensive way, the most recent available information regarding nutritional counseling in CMPA for a successful dietetic intervention of the casuistry that may arise during early infancy.
  

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  1.

  Chela-Alvarez X, Leiva A, Gallardo-Alfaro L, Bulilete O, Vidal-Thomas M, Llobera J. Anxiety, Depression, and Concern About Employment Status of Hotel Housekeepers in the Balearic Islands During the COVID-19 Pandemic: A Longitudinal Study. Frontiers in Psychology [Internet]. Frontiers Media SA; 2022 Apr.;13. https://doi.org/10.3389%2Ffpsyg.2022.842335

  URLBibTeXEndNoteDOIBibSonomyDownload

  @article{Chela_Alvarez_2022,
  author = {Chela-Alvarez, Xenia and Leiva, Alfonso and Gallardo-Alfaro, Laura and Bulilete, Oana and Vidal-Thomas, MClara and Llobera, Joan},
  journal = {Frontiers in Psychology},
  keywords = {grapp-caib myown},
  month = {apr},
  publisher = {Frontiers Media SA},
  title = {Anxiety, Depression, and Concern About Employment Status of Hotel Housekeepers in the Balearic Islands During the COVID-19 Pandemic: A Longitudinal Study},
  volume = 13,
  year = 2022
  }
  

  %0 Journal Article
  %1 Chela_Alvarez_2022
  %A Chela-Alvarez, Xenia
  %A Leiva, Alfonso
  %A Gallardo-Alfaro, Laura
  %A Bulilete, Oana
  %A Vidal-Thomas, MClara
  %A Llobera, Joan
  %D 2022
  %I Frontiers Media SA
  %J Frontiers in Psychology
  %R 10.3389/fpsyg.2022.842335
  %T Anxiety, Depression, and Concern About Employment Status of Hotel Housekeepers in the Balearic Islands During the COVID-19 Pandemic: A Longitudinal Study
  %U https://doi.org/10.3389%2Ffpsyg.2022.842335
  %V 13
  

• 
  1.

  López-González AA, Ramírez Manent JI, Vicente-Herrero MT, García Ruiz E, Albaladejo Blanco M, López Safont N. Prevalence of diabesity in the Spanish working population: influence of sociodemographic variables and tobacco consumption. Anales del Sistema Sanitario de Navarra [Internet]. Gobierno de Navarra; 2022 Nov.;. https://doi.org/10.23938%2Fassn.0977

  URLBibTeXEndNoteDOIBibSonomyDownload

  @article{L_pez_Gonz_lez_2021,
  author = {López-González, A. A. and Ramírez Manent, J. I. and Vicente-Herrero, M. T. and García Ruiz, E. and Albaladejo Blanco, M. and López Safont, N.},
  journal = {Anales del Sistema Sanitario de Navarra},
  keywords = {grapp-caib},
  month = {nov},
  publisher = {Gobierno de Navarra},
  title = {Prevalence of diabesity in the Spanish working population: influence of sociodemographic variables and tobacco consumption},
  year = 2022
  }
  

  %0 Journal Article
  %1 L_pez_Gonz_lez_2021
  %A López-González, A. A.
  %A Ramírez Manent, J. I.
  %A Vicente-Herrero, M. T.
  %A García Ruiz, E.
  %A Albaladejo Blanco, M.
  %A López Safont, N.
  %D 2022
  %I Gobierno de Navarra
  %J Anales del Sistema Sanitario de Navarra
  %R 10.23938/assn.0977
  %T Prevalence of diabesity in the Spanish working population: influence of sociodemographic variables and tobacco consumption
  %U https://doi.org/10.23938%2Fassn.0977
  

• 
  1.

  Galmes-Panades AM, Bennasar-Veny M, Oliver P, Garcia-Coll N, Chaplin A, Fresneda S, Gallardo-Alfaro L, García-Ruano C, Konieczna J, Leiva A, Masmiquel L, Pico C, Ricci-Cabello I, Romaguera D, Rivera R, Sanchis P, Vidal-Conti J, Yañez AM. Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial). Metabolites. 2022;12(12).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes. A two-phase, parallel, randomised, controlled clinical trial will be carried out, in 210 participants. In phase 1, 120 participants will be randomized into four arms: (1) aerobic exercise, (2) aerobic exercise combined with resistance, (3) high-intensity intervallic exercise and (4) control group. In phase 2, 90 new participants will be randomized into three arms, using the exercise modality that showed the best glycaemic control in phase 1 in the following manner: (1) frequency of 5 days/week, (2) frequency of 3 days/week and (3) frequency of 2 days/week. The control group (n = 30) will be included in phase 1 to evaluate the effect of any type of intervention versus no intervention. Data collection will be performed at baseline and after 15 weeks of follow up. Sociodemographic data, medication, comorbidity, blood biochemical parameters, blood pressure, anthropometric measurements, body composition, physical activity, sedentary lifestyle, diet, smoking, alcohol consumption, quality of life and sleep questionnaires will be collected. Physical activity, sedentary behaviour and sleep will be further determined with an accelerometer, and continuous glycaemia will be determined with a glycaemic monitor, both during seven days, at two time points. The main dependent variable will be the reduction in the mean amplitude of glycaemic excursions. The impact of these interventions on health will also be evaluated through gene expression analysis in peripheral blood cells. The results of this study will contribute to a better understanding of the mechanisms behind the glucose response to physical exercise in a population with prediabetes as well as improve physical exercise prescriptions for diabetes prevention. Increasing glycaemic control in people with prediabetes through physical exercise offers an opportunity to prevent diabetes and reduce associated comorbidities and health costs.

  @article{RN1,
  abstract = {To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes. A two-phase, parallel, randomised, controlled clinical trial will be carried out, in 210 participants. In phase 1, 120 participants will be randomized into four arms: (1) aerobic exercise, (2) aerobic exercise combined with resistance, (3) high-intensity intervallic exercise and (4) control group. In phase 2, 90 new participants will be randomized into three arms, using the exercise modality that showed the best glycaemic control in phase 1 in the following manner: (1) frequency of 5 days/week, (2) frequency of 3 days/week and (3) frequency of 2 days/week. The control group (n = 30) will be included in phase 1 to evaluate the effect of any type of intervention versus no intervention. Data collection will be performed at baseline and after 15 weeks of follow up. Sociodemographic data, medication, comorbidity, blood biochemical parameters, blood pressure, anthropometric measurements, body composition, physical activity, sedentary lifestyle, diet, smoking, alcohol consumption, quality of life and sleep questionnaires will be collected. Physical activity, sedentary behaviour and sleep will be further determined with an accelerometer, and continuous glycaemia will be determined with a glycaemic monitor, both during seven days, at two time points. The main dependent variable will be the reduction in the mean amplitude of glycaemic excursions. The impact of these interventions on health will also be evaluated through gene expression analysis in peripheral blood cells. The results of this study will contribute to a better understanding of the mechanisms behind the glucose response to physical exercise in a population with prediabetes as well as improve physical exercise prescriptions for diabetes prevention. Increasing glycaemic control in people with prediabetes through physical exercise offers an opportunity to prevent diabetes and reduce associated comorbidities and health costs.},
  author = {Galmes-Panades, A. M. and Bennasar-Veny, M. and Oliver, P. and Garcia-Coll, N. and Chaplin, A. and Fresneda, S. and Gallardo-Alfaro, L. and García-Ruano, C. and Konieczna, J. and Leiva, A. and Masmiquel, L. and Pico, C. and Ricci-Cabello, I. and Romaguera, D. and Rivera, R. and Sanchis, P. and Vidal-Conti, J. and Yañez, A. M.},
  journal = {Metabolites},
  keywords = {grapp-caib},
  number = 12,
  title = {Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial)},
  type = {Journal Article},
  volume = 12,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN1
  %A Galmes-Panades, A. M.
  %A Bennasar-Veny, M.
  %A Oliver, P.
  %A Garcia-Coll, N.
  %A Chaplin, A.
  %A Fresneda, S.
  %A Gallardo-Alfaro, L.
  %A García-Ruano, C.
  %A Konieczna, J.
  %A Leiva, A.
  %A Masmiquel, L.
  %A Pico, C.
  %A Ricci-Cabello, I.
  %A Romaguera, D.
  %A Rivera, R.
  %A Sanchis, P.
  %A Vidal-Conti, J.
  %A Yañez, A. M.
  %D 2022
  %J Metabolites
  %N 12
  %R 10.3390/metabo12121286
  %T Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial)
  %V 12
  %X To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes. A two-phase, parallel, randomised, controlled clinical trial will be carried out, in 210 participants. In phase 1, 120 participants will be randomized into four arms: (1) aerobic exercise, (2) aerobic exercise combined with resistance, (3) high-intensity intervallic exercise and (4) control group. In phase 2, 90 new participants will be randomized into three arms, using the exercise modality that showed the best glycaemic control in phase 1 in the following manner: (1) frequency of 5 days/week, (2) frequency of 3 days/week and (3) frequency of 2 days/week. The control group (n = 30) will be included in phase 1 to evaluate the effect of any type of intervention versus no intervention. Data collection will be performed at baseline and after 15 weeks of follow up. Sociodemographic data, medication, comorbidity, blood biochemical parameters, blood pressure, anthropometric measurements, body composition, physical activity, sedentary lifestyle, diet, smoking, alcohol consumption, quality of life and sleep questionnaires will be collected. Physical activity, sedentary behaviour and sleep will be further determined with an accelerometer, and continuous glycaemia will be determined with a glycaemic monitor, both during seven days, at two time points. The main dependent variable will be the reduction in the mean amplitude of glycaemic excursions. The impact of these interventions on health will also be evaluated through gene expression analysis in peripheral blood cells. The results of this study will contribute to a better understanding of the mechanisms behind the glucose response to physical exercise in a population with prediabetes as well as improve physical exercise prescriptions for diabetes prevention. Increasing glycaemic control in people with prediabetes through physical exercise offers an opportunity to prevent diabetes and reduce associated comorbidities and health costs.
  

2021

• 
  1.

  Xu C-J, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A, Mason D, Chatzi L, Porta D, Lodrup Carlsen KC, Baïz N, Madore A-M, Alenius H, van Rijkom B, Jankipersadsing SA, van der Vlies P, Kull I, van Hage M, Bustamante M, Lertxundi A, Torrent M, Santorelli G, Fantini MP, Hovland V, Pesce G, Fyhrquist N, Laatikainen T, Nawijn MC, Li Y, Wijmenga C, Netea MG, Bousquet J, Anto JM, Laprise C, Haahtela T, Annesi-Maesano I, Carlsen K-H, Gori D, Kogevinas M, Wright J, Söderhäll C, Vonk JM, Sunyer J, Melén E, Koppelman GH. Shared DNA methylation signatures in childhood allergy: The MeDALL study. Journal of Allergy and Clinical Immunology [Internet]. 2021;147(3):1031-40. https://www.sciencedirect.com/science/article/pii/S0091674920317668

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Background Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. Objective We sought to identify DNA methylation profiles associated with childhood allergy. Methods Within the European Mechanisms of the Development of Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional design. Allergy was defined as having symptoms from at least 1 allergic disease (asthma, rhinitis, or eczema) and positive serum-specific IgE to common aeroallergens. The discovery study included 219 case patients and 417 controls at age 4 years and 228 case patients and 593 controls at age 8 years from 3 birth cohorts, with replication analyses in 325 case patients and 1111 controls. We performed additional analyses on 21 replicated sites in 785 case patients and 2124 controls by allergic symptoms only from 8 cohorts, 3 of which were not previously included in analyses. Results We identified 80 differentially methylated CpG sites that showed a 1% to 3% methylation difference in the discovery phase, of which 21 (including 5 novel CpG sites) passed genome-wide significance after meta-analysis. All 21 CpG sites were also significantly differentially methylated with allergic symptoms and shared between asthma, rhinitis, and eczema. The 21 CpG sites mapped to relevant genes, including ACOT7, LMAN3, and CLDN23. All 21 CpG sties were differently methylated in asthma in isolated eosinophils, and 10 were replicated in respiratory epithelium. Conclusion Reduced whole blood DNA methylation at 21 CpG sites was significantly associated with childhood allergy. The findings provide novel insights into the shared molecular mechanisms underlying asthma, rhinitis, and eczema.

  @article{XU20211031,
  abstract = {Background Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. Objective We sought to identify DNA methylation profiles associated with childhood allergy. Methods Within the European Mechanisms of the Development of Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional design. Allergy was defined as having symptoms from at least 1 allergic disease (asthma, rhinitis, or eczema) and positive serum-specific IgE to common aeroallergens. The discovery study included 219 case patients and 417 controls at age 4 years and 228 case patients and 593 controls at age 8 years from 3 birth cohorts, with replication analyses in 325 case patients and 1111 controls. We performed additional analyses on 21 replicated sites in 785 case patients and 2124 controls by allergic symptoms only from 8 cohorts, 3 of which were not previously included in analyses. Results We identified 80 differentially methylated CpG sites that showed a 1% to 3% methylation difference in the discovery phase, of which 21 (including 5 novel CpG sites) passed genome-wide significance after meta-analysis. All 21 CpG sites were also significantly differentially methylated with allergic symptoms and shared between asthma, rhinitis, and eczema. The 21 CpG sites mapped to relevant genes, including ACOT7, LMAN3, and CLDN23. All 21 CpG sties were differently methylated in asthma in isolated eosinophils, and 10 were replicated in respiratory epithelium. Conclusion Reduced whole blood DNA methylation at 21 CpG sites was significantly associated with childhood allergy. The findings provide novel insights into the shared molecular mechanisms underlying asthma, rhinitis, and eczema.},
  author = {Xu, Cheng-Jian and Gruzieva, Olena and Qi, Cancan and Esplugues, Ana and Gehring, Ulrike and Bergström, Anna and Mason, Dan and Chatzi, Leda and Porta, Daniela and Lodrup Carlsen, Karin C. and Baïz, Nour and Madore, Anne-Marie and Alenius, Harri and van Rijkom, Bianca and Jankipersadsing, Soesma A. and van der Vlies, Pieter and Kull, Inger and van Hage, Marianne and Bustamante, Mariona and Lertxundi, Aitana and Torrent, Matias and Santorelli, Gillian and Fantini, Maria Pia and Hovland, Vegard and Pesce, Giancarlo and Fyhrquist, Nanna and Laatikainen, Tiina and Nawijn, Martijn C. and Li, Yang and Wijmenga, Cisca and Netea, Mihai G. and Bousquet, Jean and Anto, Josep M. and Laprise, Catherine and Haahtela, Tari and Annesi-Maesano, Isabella and Carlsen, Kai-Håkon and Gori, Davide and Kogevinas, Manolis and Wright, John and Söderhäll, Cilla and Vonk, Judith M. and Sunyer, Jordi and Melén, Erik and Koppelman, Gerard H.},
  journal = {Journal of Allergy and Clinical Immunology},
  keywords = {grapp-caib},
  number = 3,
  pages = {1031-1040},
  title = {Shared DNA methylation signatures in childhood allergy: The MeDALL study},
  volume = 147,
  year = 2021
  }
  

  %0 Journal Article
  %1 XU20211031
  %A Xu, Cheng-Jian
  %A Gruzieva, Olena
  %A Qi, Cancan
  %A Esplugues, Ana
  %A Gehring, Ulrike
  %A Bergström, Anna
  %A Mason, Dan
  %A Chatzi, Leda
  %A Porta, Daniela
  %A Lodrup Carlsen, Karin C.
  %A Baïz, Nour
  %A Madore, Anne-Marie
  %A Alenius, Harri
  %A van Rijkom, Bianca
  %A Jankipersadsing, Soesma A.
  %A van der Vlies, Pieter
  %A Kull, Inger
  %A van Hage, Marianne
  %A Bustamante, Mariona
  %A Lertxundi, Aitana
  %A Torrent, Matias
  %A Santorelli, Gillian
  %A Fantini, Maria Pia
  %A Hovland, Vegard
  %A Pesce, Giancarlo
  %A Fyhrquist, Nanna
  %A Laatikainen, Tiina
  %A Nawijn, Martijn C.
  %A Li, Yang
  %A Wijmenga, Cisca
  %A Netea, Mihai G.
  %A Bousquet, Jean
  %A Anto, Josep M.
  %A Laprise, Catherine
  %A Haahtela, Tari
  %A Annesi-Maesano, Isabella
  %A Carlsen, Kai-Håkon
  %A Gori, Davide
  %A Kogevinas, Manolis
  %A Wright, John
  %A Söderhäll, Cilla
  %A Vonk, Judith M.
  %A Sunyer, Jordi
  %A Melén, Erik
  %A Koppelman, Gerard H.
  %D 2021
  %J Journal of Allergy and Clinical Immunology
  %N 3
  %P 1031-1040
  %R https://doi.org/10.1016/j.jaci.2020.11.044
  %T Shared DNA methylation signatures in childhood allergy: The MeDALL study
  %U https://www.sciencedirect.com/science/article/pii/S0091674920317668
  %V 147
  %X Background Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. Objective We sought to identify DNA methylation profiles associated with childhood allergy. Methods Within the European Mechanisms of the Development of Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional design. Allergy was defined as having symptoms from at least 1 allergic disease (asthma, rhinitis, or eczema) and positive serum-specific IgE to common aeroallergens. The discovery study included 219 case patients and 417 controls at age 4 years and 228 case patients and 593 controls at age 8 years from 3 birth cohorts, with replication analyses in 325 case patients and 1111 controls. We performed additional analyses on 21 replicated sites in 785 case patients and 2124 controls by allergic symptoms only from 8 cohorts, 3 of which were not previously included in analyses. Results We identified 80 differentially methylated CpG sites that showed a 1% to 3% methylation difference in the discovery phase, of which 21 (including 5 novel CpG sites) passed genome-wide significance after meta-analysis. All 21 CpG sites were also significantly differentially methylated with allergic symptoms and shared between asthma, rhinitis, and eczema. The 21 CpG sites mapped to relevant genes, including ACOT7, LMAN3, and CLDN23. All 21 CpG sties were differently methylated in asthma in isolated eosinophils, and 10 were replicated in respiratory epithelium. Conclusion Reduced whole blood DNA methylation at 21 CpG sites was significantly associated with childhood allergy. The findings provide novel insights into the shared molecular mechanisms underlying asthma, rhinitis, and eczema.
  

• 
  1.

  Zabaleta-Del-Olmo E, Casajuana-Closas M, López-Jiménez T, Pombo H, Pons-Vigués M, Pujol-Ribera E, Cabezas-Peña C, Llobera J, Martí-Lluch R, Vicens C, Motrico E, Gómez-Gómez I, Maderuelo-Fernández J, Recio-Rodriguez JI, Masluk B, Contreras-Martos S, Jacques-Aviñó C, Aznar-Lou I, Gil-Girbau M, Clavería A, Magallón-Botaya R, Bellón J, Ramos R, Sanchez-Perez A, Moreno-Peral P, Leiva A, González-Formoso C, Bolíbar B. Multiple health behaviour change primary care intervention for smoking cessation, physical activity and healthy diet in adults 45 to 75 years old (EIRA study): a hybrid effectiveness-implementation cluster randomised trial. BMC Public Health [Internet]. 2021;21(1):2208. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642878/pdf/12889_2021_Article_11982.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: This study aimed to evaluate the effectiveness of a) a Multiple Health Behaviour Change (MHBC) intervention on reducing smoking, increasing physical activity and adherence to a Mediterranean dietary pattern in people aged 45-75 years compared to usual care; and b) an implementation strategy. METHODS: A cluster randomised effectiveness-implementation hybrid trial-type 2 with two parallel groups was conducted in 25 Spanish Primary Health Care (PHC) centres (3062 participants): 12 centres (1481 participants) were randomised to the intervention and 13 (1581 participants) to the control group (usual care). The intervention was based on the Transtheoretical Model and focused on all target behaviours using individual, group and community approaches. PHC professionals made it during routine care. The implementation strategy was based on the Consolidated Framework for Implementation Research (CFIR). Data were analysed using generalised linear mixed models, accounting for clustering. A mixed-methods data analysis was used to evaluate implementation outcomes (adoption, acceptability, appropriateness, feasibility and fidelity) and determinants of implementation success. RESULTS: 14.5% of participants in the intervention group and 8.9% in the usual care group showed a positive change in two or all the target behaviours. Intervention was more effective in promoting dietary behaviour change (31.9% vs 21.4%). The overall adoption rate by professionals was 48.7%. Early and final appropriateness were perceived by professionals as moderate. Early acceptability was high, whereas final acceptability was only moderate. Initial and final acceptability as perceived by the participants was high, and appropriateness moderate. Consent and recruitment rates were 82.0% and 65.5%, respectively, intervention uptake was 89.5% and completion rate 74.7%. The global value of the percentage of approaches with fidelity ≥50% was 16.7%. Eight CFIR constructs distinguished between high and low implementation, five corresponding to the Inner Setting domain. CONCLUSIONS: Compared to usual care, the EIRA intervention was more effective in promoting MHBC and dietary behaviour change. Implementation outcomes were satisfactory except for the fidelity to the planned intervention, which was low. The organisational and structural contexts of the centres proved to be significant determinants of implementation effectiveness. TRIAL REGISTRATION: ClinicalTrials.gov , NCT03136211 . Registered 2 May 2017, "retrospectively registered".

  @article{RN30,
  abstract = {BACKGROUND: This study aimed to evaluate the effectiveness of a) a Multiple Health Behaviour Change (MHBC) intervention on reducing smoking, increasing physical activity and adherence to a Mediterranean dietary pattern in people aged 45-75 years compared to usual care; and b) an implementation strategy. METHODS: A cluster randomised effectiveness-implementation hybrid trial-type 2 with two parallel groups was conducted in 25 Spanish Primary Health Care (PHC) centres (3062 participants): 12 centres (1481 participants) were randomised to the intervention and 13 (1581 participants) to the control group (usual care). The intervention was based on the Transtheoretical Model and focused on all target behaviours using individual, group and community approaches. PHC professionals made it during routine care. The implementation strategy was based on the Consolidated Framework for Implementation Research (CFIR). Data were analysed using generalised linear mixed models, accounting for clustering. A mixed-methods data analysis was used to evaluate implementation outcomes (adoption, acceptability, appropriateness, feasibility and fidelity) and determinants of implementation success. RESULTS: 14.5% of participants in the intervention group and 8.9% in the usual care group showed a positive change in two or all the target behaviours. Intervention was more effective in promoting dietary behaviour change (31.9% vs 21.4%). The overall adoption rate by professionals was 48.7%. Early and final appropriateness were perceived by professionals as moderate. Early acceptability was high, whereas final acceptability was only moderate. Initial and final acceptability as perceived by the participants was high, and appropriateness moderate. Consent and recruitment rates were 82.0% and 65.5%, respectively, intervention uptake was 89.5% and completion rate 74.7%. The global value of the percentage of approaches with fidelity ≥50% was 16.7%. Eight CFIR constructs distinguished between high and low implementation, five corresponding to the Inner Setting domain. CONCLUSIONS: Compared to usual care, the EIRA intervention was more effective in promoting MHBC and dietary behaviour change. Implementation outcomes were satisfactory except for the fidelity to the planned intervention, which was low. The organisational and structural contexts of the centres proved to be significant determinants of implementation effectiveness. TRIAL REGISTRATION: ClinicalTrials.gov , NCT03136211 . Registered 2 May 2017, "retrospectively registered".},
  author = {Zabaleta-Del-Olmo, E. and Casajuana-Closas, M. and López-Jiménez, T. and Pombo, H. and Pons-Vigués, M. and Pujol-Ribera, E. and Cabezas-Peña, C. and Llobera, J. and Martí-Lluch, R. and Vicens, C. and Motrico, E. and Gómez-Gómez, I. and Maderuelo-Fernández, JÁ and Recio-Rodriguez, J. I. and Masluk, B. and Contreras-Martos, S. and Jacques-Aviñó, C. and Aznar-Lou, I. and Gil-Girbau, M. and Clavería, A. and Magallón-Botaya, R. and Bellón, JÁ and Ramos, R. and Sanchez-Perez, A. and Moreno-Peral, P. and Leiva, A. and González-Formoso, C. and Bolíbar, B.},
  journal = {BMC Public Health},
  keywords = {grapp-caib},
  number = 1,
  pages = 2208,
  title = {Multiple health behaviour change primary care intervention for smoking cessation, physical activity and healthy diet in adults 45 to 75 years old (EIRA study): a hybrid effectiveness-implementation cluster randomised trial},
  type = {Journal Article},
  volume = 21,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN30
  %A Zabaleta-Del-Olmo, E.
  %A Casajuana-Closas, M.
  %A López-Jiménez, T.
  %A Pombo, H.
  %A Pons-Vigués, M.
  %A Pujol-Ribera, E.
  %A Cabezas-Peña, C.
  %A Llobera, J.
  %A Martí-Lluch, R.
  %A Vicens, C.
  %A Motrico, E.
  %A Gómez-Gómez, I.
  %A Maderuelo-Fernández, JÁ
  %A Recio-Rodriguez, J. I.
  %A Masluk, B.
  %A Contreras-Martos, S.
  %A Jacques-Aviñó, C.
  %A Aznar-Lou, I.
  %A Gil-Girbau, M.
  %A Clavería, A.
  %A Magallón-Botaya, R.
  %A Bellón, JÁ
  %A Ramos, R.
  %A Sanchez-Perez, A.
  %A Moreno-Peral, P.
  %A Leiva, A.
  %A González-Formoso, C.
  %A Bolíbar, B.
  %D 2021
  %J BMC Public Health
  %N 1
  %P 2208
  %R 10.1186/s12889-021-11982-4
  %T Multiple health behaviour change primary care intervention for smoking cessation, physical activity and healthy diet in adults 45 to 75 years old (EIRA study): a hybrid effectiveness-implementation cluster randomised trial
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642878/pdf/12889_2021_Article_11982.pdf
  %V 21
  %X BACKGROUND: This study aimed to evaluate the effectiveness of a) a Multiple Health Behaviour Change (MHBC) intervention on reducing smoking, increasing physical activity and adherence to a Mediterranean dietary pattern in people aged 45-75 years compared to usual care; and b) an implementation strategy. METHODS: A cluster randomised effectiveness-implementation hybrid trial-type 2 with two parallel groups was conducted in 25 Spanish Primary Health Care (PHC) centres (3062 participants): 12 centres (1481 participants) were randomised to the intervention and 13 (1581 participants) to the control group (usual care). The intervention was based on the Transtheoretical Model and focused on all target behaviours using individual, group and community approaches. PHC professionals made it during routine care. The implementation strategy was based on the Consolidated Framework for Implementation Research (CFIR). Data were analysed using generalised linear mixed models, accounting for clustering. A mixed-methods data analysis was used to evaluate implementation outcomes (adoption, acceptability, appropriateness, feasibility and fidelity) and determinants of implementation success. RESULTS: 14.5% of participants in the intervention group and 8.9% in the usual care group showed a positive change in two or all the target behaviours. Intervention was more effective in promoting dietary behaviour change (31.9% vs 21.4%). The overall adoption rate by professionals was 48.7%. Early and final appropriateness were perceived by professionals as moderate. Early acceptability was high, whereas final acceptability was only moderate. Initial and final acceptability as perceived by the participants was high, and appropriateness moderate. Consent and recruitment rates were 82.0% and 65.5%, respectively, intervention uptake was 89.5% and completion rate 74.7%. The global value of the percentage of approaches with fidelity ≥50% was 16.7%. Eight CFIR constructs distinguished between high and low implementation, five corresponding to the Inner Setting domain. CONCLUSIONS: Compared to usual care, the EIRA intervention was more effective in promoting MHBC and dietary behaviour change. Implementation outcomes were satisfactory except for the fidelity to the planned intervention, which was low. The organisational and structural contexts of the centres proved to be significant determinants of implementation effectiveness. TRIAL REGISTRATION: ClinicalTrials.gov , NCT03136211 . Registered 2 May 2017, "retrospectively registered".
  

• 
  1.

  Garcia-Sangenís A, Morros R, Aguilar-Sánchez M, Medina-Perucha L, Leiva A, Ripoll J, Martínez-Pecharromán M, Bartolomé-Moreno CB, Magallon Botaya R, Marín-Cañada J, Molero JM, Moragas A, Troncoso A, Monfà R, Llor C. Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical textellipsis. BMJ Open [Internet]. British Medical Journal Publishing Group; 2021;11(11). https://bmjopen.bmj.com/content/11/11/e055898

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Introduction Uncomplicated lower urinary tract infections (uLUTI) are a common problem in primary care. Current local guidelines recommend the use of a single 3 g dose of fosfomycin. However, most general practitioners (GP) prefer short-course therapies to single-dose therapy. No study has compared head-to-head short-course antimicrobial agents for uLUTIs. Therefore, the aim of this randomised clinical trial is to compare three different short-course antibiotic therapies with a single-dose of fosfomycin for these infections.Methods and analysis This will be a pragmatic, multicentre, parallel group, open trial. Women aged 18 or older and with symptoms of uLUTI and a positive urine dipstick analysis will be randomised to one of the following four groups: a single dose of 3 g of fosfomycin, 2 days of 3 g of fosfomycin o.d., 3 days of pivmecillinam 400 mg three times per day (t.i.d) or 5 days of nitrofurantoin 100 mg t.i.d. A total sample of 1120 patients was calculated. The primary endpoint is clinical effectiveness at day 7, defined as cure of symptoms reported by the patients in a diary including four symptoms: dysuria, urgency, frequency and suprapubic pain, which will be scored on a 4-point severity scale (not present/mild/moderate/severe). Follow-up visits are scheduled at days 7 (phone call), 14 and 28 for assessing evolution. Urine samples will be collected in the three on-site visits and urine cultures performed. If positive, antibiograms for the three antibiotics studied will be performed. Bacterial eradication will be measured at days 14 and 28.Ethics and dissemination The study was approved by the Ethical Board of IDIAP Jordi Gol (reference number: 21/173-AC) and Spanish Agency of Medicines and Medical Devices. The findings of this trial will be disseminated through research conferences and peer-review journals.Trial registration number NCT04959331; EudraCT Number: 2021-001332-26.Time schedule January 2022 to April 2023.

  @article{Garcia-Sangen'ise055898,
  abstract = {Introduction Uncomplicated lower urinary tract infections (uLUTI) are a common problem in primary care. Current local guidelines recommend the use of a single 3 g dose of fosfomycin. However, most general practitioners (GP) prefer short-course therapies to single-dose therapy. No study has compared head-to-head short-course antimicrobial agents for uLUTIs. Therefore, the aim of this randomised clinical trial is to compare three different short-course antibiotic therapies with a single-dose of fosfomycin for these infections.Methods and analysis This will be a pragmatic, multicentre, parallel group, open trial. Women aged 18 or older and with symptoms of uLUTI and a positive urine dipstick analysis will be randomised to one of the following four groups: a single dose of 3 g of fosfomycin, 2 days of 3 g of fosfomycin o.d., 3 days of pivmecillinam 400 mg three times per day (t.i.d) or 5 days of nitrofurantoin 100 mg t.i.d. A total sample of 1120 patients was calculated. The primary endpoint is clinical effectiveness at day 7, defined as cure of symptoms reported by the patients in a diary including four symptoms: dysuria, urgency, frequency and suprapubic pain, which will be scored on a 4-point severity scale (not present/mild/moderate/severe). Follow-up visits are scheduled at days 7 (phone call), 14 and 28 for assessing evolution. Urine samples will be collected in the three on-site visits and urine cultures performed. If positive, antibiograms for the three antibiotics studied will be performed. Bacterial eradication will be measured at days 14 and 28.Ethics and dissemination The study was approved by the Ethical Board of IDIAP Jordi Gol (reference number: 21/173-AC) and Spanish Agency of Medicines and Medical Devices. The findings of this trial will be disseminated through research conferences and peer-review journals.Trial registration number NCT04959331; EudraCT Number: 2021-001332-26.Time schedule January 2022 to April 2023.},
  author = {Garcia-Sangenís, A. and Morros, R. and Aguilar-Sánchez, M. and Medina-Perucha, L. and Leiva, A. and Ripoll, J. and Martínez-Pecharromán, M. and Bartolomé-Moreno, C. B. and Magallon Botaya, R. and Marín-Cañada, J. and Molero, J. M. and Moragas, A. and Troncoso, A. and Monfà, R. and Llor, C.},
  journal = {BMJ Open},
  keywords = {grapp-caib myown},
  number = 11,
  publisher = {British Medical Journal Publishing Group},
  title = {Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical textellipsis},
  volume = 11,
  year = 2021
  }
  

  %0 Journal Article
  %1 Garcia-Sangen'ise055898
  %A Garcia-Sangenís, A.
  %A Morros, R.
  %A Aguilar-Sánchez, M.
  %A Medina-Perucha, L.
  %A Leiva, A.
  %A Ripoll, J.
  %A Martínez-Pecharromán, M.
  %A Bartolomé-Moreno, C. B.
  %A Magallon Botaya, R.
  %A Marín-Cañada, J.
  %A Molero, J. M.
  %A Moragas, A.
  %A Troncoso, A.
  %A Monfà, R.
  %A Llor, C.
  %D 2021
  %I British Medical Journal Publishing Group
  %J BMJ Open
  %N 11
  %R 10.1136/bmjopen-2021-055898
  %T Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical textellipsis
  %U https://bmjopen.bmj.com/content/11/11/e055898
  %V 11
  %X Introduction Uncomplicated lower urinary tract infections (uLUTI) are a common problem in primary care. Current local guidelines recommend the use of a single 3 g dose of fosfomycin. However, most general practitioners (GP) prefer short-course therapies to single-dose therapy. No study has compared head-to-head short-course antimicrobial agents for uLUTIs. Therefore, the aim of this randomised clinical trial is to compare three different short-course antibiotic therapies with a single-dose of fosfomycin for these infections.Methods and analysis This will be a pragmatic, multicentre, parallel group, open trial. Women aged 18 or older and with symptoms of uLUTI and a positive urine dipstick analysis will be randomised to one of the following four groups: a single dose of 3 g of fosfomycin, 2 days of 3 g of fosfomycin o.d., 3 days of pivmecillinam 400 mg three times per day (t.i.d) or 5 days of nitrofurantoin 100 mg t.i.d. A total sample of 1120 patients was calculated. The primary endpoint is clinical effectiveness at day 7, defined as cure of symptoms reported by the patients in a diary including four symptoms: dysuria, urgency, frequency and suprapubic pain, which will be scored on a 4-point severity scale (not present/mild/moderate/severe). Follow-up visits are scheduled at days 7 (phone call), 14 and 28 for assessing evolution. Urine samples will be collected in the three on-site visits and urine cultures performed. If positive, antibiograms for the three antibiotics studied will be performed. Bacterial eradication will be measured at days 14 and 28.Ethics and dissemination The study was approved by the Ethical Board of IDIAP Jordi Gol (reference number: 21/173-AC) and Spanish Agency of Medicines and Medical Devices. The findings of this trial will be disseminated through research conferences and peer-review journals.Trial registration number NCT04959331; EudraCT Number: 2021-001332-26.Time schedule January 2022 to April 2023.
  

• 
  1.

  Fiol deRoque MA, Serrano-Ripol MJ, Gens-Barberà M, Sánchez E, Mayer MA, Martín-Luján F, Valderas JM, Ricci-Cabello I. Impacto de la pandemia de COVID-19 en la seguridad del paciente percibida por los pacientes en Atención Primaria. Atención Primaria [Internet]. 2021;53:102222. https://www.sciencedirect.com/science/article/pii/S0212656721002560

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Resumen Objetivo Evaluar el impacto de los cambios introducidos en respuesta a la pandemia sobre la seguridad del paciente (SP) percibida por los pacientes en Atención Primaria. Diseño Estudio observacional prospectivo de panel (centro de salud [CS]) basado en dos encuestas transversales. Emplazamiento 29 CS de tres regiones sanitarias de España (Mallorca, Cataluña Central y Camp de Tarragona). Participantes Muestreo aleatorio de pacientes que consultaron los CS antes (n=2.199) y durante (n=1.955) la pandemia. Mediciones principales Se administró el cuestionario validado PREOS-PC, que evalúa la SP experimentada por los pacientes atendidos en Atención Primaria. Se compararon las puntuaciones medias en las escalas «experiencias de errores» y «daño» en ambos períodos y se realizaron análisis de regresión multinivel para estudiar las variaciones en las características de los pacientes y de los CS asociadas a la percepción de peores niveles de seguridad. Se realizó un análisis cualitativo de contenido sobre las experiencias de los pacientes durante la pandemia. Resultados Las puntuaciones de «errores» y «daño» empeoraron significativamente durante el período de COVID-19 (92,65 a 88,81 [d de Cohen=0,27]; y 96,92 a 79,97 [d=0,70], respectivamente). Se observó un mayor empeoramiento en mujeres, personas con menor nivel educativo, peor estado de salud y con más años adscritos al centro. También se observaron diferencias en función de la región sanitaria. Conclusiones Durante la pandemia ha empeorado la SP percibida por los pacientes atendidos en Atención Primaria, siendo el impacto desigual según las características sociodemográficas de los pacientes y el perfil de los centros de salud. Objective To evaluate the impact of the changes introduced in response to the pandemic on patient-reported patient safety in Primary Care. Design Prospective observational panel study (health center) based on two cross-sectional surveys. Setting 29 Primary Health Care centers from three Spanish health regions (Mallorca, Catalunya Central and Camp de Tarragona). Participants Random sample of patients visiting their centers before (n=2199 patients) and during the pandemic (n=1955 patients) Main measurements We used the PREOS-PC questionnaire, a validated instrument which assesses patient-reported patient safety in Primary Care. We compared mean scores of the “experiences of errors” and “harm” scales in both periods, and built multilevel regression analyzes to study the variations in patient and center characteristics associated with worse levels of safety. A qualitative (content) analysis of patients’ experiences during the pandemic was also performed. Results The “experiences of errors” and “harm” scales scores significantly worsened during the COVID-19 period (92.65 to 88.81 (Cohen's d=0.27); and 96.92 to 79.97 (d=0.70), respectively). Patient and center characteristics associated to worsened scores were: women, people with a lower educational level, worse health status, more years assigned to the center, and health region. Conclusions During the pandemic, a perceptible worsening in patient safety perceived by patients treated in Primary Care has been observed, which has differentially affected patients according to their sociodemographic characteristics or health center profiles.

  @article{FIOLDEROQUE2021102222,
  abstract = {Resumen Objetivo Evaluar el impacto de los cambios introducidos en respuesta a la pandemia sobre la seguridad del paciente (SP) percibida por los pacientes en Atención Primaria. Diseño Estudio observacional prospectivo de panel (centro de salud [CS]) basado en dos encuestas transversales. Emplazamiento 29 CS de tres regiones sanitarias de España (Mallorca, Cataluña Central y Camp de Tarragona). Participantes Muestreo aleatorio de pacientes que consultaron los CS antes (n=2.199) y durante (n=1.955) la pandemia. Mediciones principales Se administró el cuestionario validado PREOS-PC, que evalúa la SP experimentada por los pacientes atendidos en Atención Primaria. Se compararon las puntuaciones medias en las escalas «experiencias de errores» y «daño» en ambos períodos y se realizaron análisis de regresión multinivel para estudiar las variaciones en las características de los pacientes y de los CS asociadas a la percepción de peores niveles de seguridad. Se realizó un análisis cualitativo de contenido sobre las experiencias de los pacientes durante la pandemia. Resultados Las puntuaciones de «errores» y «daño» empeoraron significativamente durante el período de COVID-19 (92,65 a 88,81 [d de Cohen=0,27]; y 96,92 a 79,97 [d=0,70], respectivamente). Se observó un mayor empeoramiento en mujeres, personas con menor nivel educativo, peor estado de salud y con más años adscritos al centro. También se observaron diferencias en función de la región sanitaria. Conclusiones Durante la pandemia ha empeorado la SP percibida por los pacientes atendidos en Atención Primaria, siendo el impacto desigual según las características sociodemográficas de los pacientes y el perfil de los centros de salud. Objective To evaluate the impact of the changes introduced in response to the pandemic on patient-reported patient safety in Primary Care. Design Prospective observational panel study (health center) based on two cross-sectional surveys. Setting 29 Primary Health Care centers from three Spanish health regions (Mallorca, Catalunya Central and Camp de Tarragona). Participants Random sample of patients visiting their centers before (n=2199 patients) and during the pandemic (n=1955 patients) Main measurements We used the PREOS-PC questionnaire, a validated instrument which assesses patient-reported patient safety in Primary Care. We compared mean scores of the “experiences of errors” and “harm” scales in both periods, and built multilevel regression analyzes to study the variations in patient and center characteristics associated with worse levels of safety. A qualitative (content) analysis of patients’ experiences during the pandemic was also performed. Results The “experiences of errors” and “harm” scales scores significantly worsened during the COVID-19 period (92.65 to 88.81 (Cohen's d=0.27); and 96.92 to 79.97 (d=0.70), respectively). Patient and center characteristics associated to worsened scores were: women, people with a lower educational level, worse health status, more years assigned to the center, and health region. Conclusions During the pandemic, a perceptible worsening in patient safety perceived by patients treated in Primary Care has been observed, which has differentially affected patients according to their sociodemographic characteristics or health center profiles.},
  author = {Fiol deRoque, Maria A. and Serrano-Ripol, Maria J. and Gens-Barberà, Montserrat and Sánchez, Encarna and Mayer, Miguel A. and Martín-Luján, Francisco and Valderas, José M. and Ricci-Cabello, Ignacio},
  journal = {Atención Primaria},
  keywords = {grapp-caib myown},
  note = {Seguridad del Paciente en Atencion Primaria},
  pages = 102222,
  title = {Impacto de la pandemia de COVID-19 en la seguridad del paciente percibida por los pacientes en Atención Primaria},
  volume = 53,
  year = 2021
  }
  

  %0 Journal Article
  %1 FIOLDEROQUE2021102222
  %A Fiol deRoque, Maria A.
  %A Serrano-Ripol, Maria J.
  %A Gens-Barberà, Montserrat
  %A Sánchez, Encarna
  %A Mayer, Miguel A.
  %A Martín-Luján, Francisco
  %A Valderas, José M.
  %A Ricci-Cabello, Ignacio
  %D 2021
  %J Atención Primaria
  %P 102222
  %R https://doi.org/10.1016/j.aprim.2021.102222
  %T Impacto de la pandemia de COVID-19 en la seguridad del paciente percibida por los pacientes en Atención Primaria
  %U https://www.sciencedirect.com/science/article/pii/S0212656721002560
  %V 53
  %X Resumen Objetivo Evaluar el impacto de los cambios introducidos en respuesta a la pandemia sobre la seguridad del paciente (SP) percibida por los pacientes en Atención Primaria. Diseño Estudio observacional prospectivo de panel (centro de salud [CS]) basado en dos encuestas transversales. Emplazamiento 29 CS de tres regiones sanitarias de España (Mallorca, Cataluña Central y Camp de Tarragona). Participantes Muestreo aleatorio de pacientes que consultaron los CS antes (n=2.199) y durante (n=1.955) la pandemia. Mediciones principales Se administró el cuestionario validado PREOS-PC, que evalúa la SP experimentada por los pacientes atendidos en Atención Primaria. Se compararon las puntuaciones medias en las escalas «experiencias de errores» y «daño» en ambos períodos y se realizaron análisis de regresión multinivel para estudiar las variaciones en las características de los pacientes y de los CS asociadas a la percepción de peores niveles de seguridad. Se realizó un análisis cualitativo de contenido sobre las experiencias de los pacientes durante la pandemia. Resultados Las puntuaciones de «errores» y «daño» empeoraron significativamente durante el período de COVID-19 (92,65 a 88,81 [d de Cohen=0,27]; y 96,92 a 79,97 [d=0,70], respectivamente). Se observó un mayor empeoramiento en mujeres, personas con menor nivel educativo, peor estado de salud y con más años adscritos al centro. También se observaron diferencias en función de la región sanitaria. Conclusiones Durante la pandemia ha empeorado la SP percibida por los pacientes atendidos en Atención Primaria, siendo el impacto desigual según las características sociodemográficas de los pacientes y el perfil de los centros de salud. Objective To evaluate the impact of the changes introduced in response to the pandemic on patient-reported patient safety in Primary Care. Design Prospective observational panel study (health center) based on two cross-sectional surveys. Setting 29 Primary Health Care centers from three Spanish health regions (Mallorca, Catalunya Central and Camp de Tarragona). Participants Random sample of patients visiting their centers before (n=2199 patients) and during the pandemic (n=1955 patients) Main measurements We used the PREOS-PC questionnaire, a validated instrument which assesses patient-reported patient safety in Primary Care. We compared mean scores of the “experiences of errors” and “harm” scales in both periods, and built multilevel regression analyzes to study the variations in patient and center characteristics associated with worse levels of safety. A qualitative (content) analysis of patients’ experiences during the pandemic was also performed. Results The “experiences of errors” and “harm” scales scores significantly worsened during the COVID-19 period (92.65 to 88.81 (Cohen's d=0.27); and 96.92 to 79.97 (d=0.70), respectively). Patient and center characteristics associated to worsened scores were: women, people with a lower educational level, worse health status, more years assigned to the center, and health region. Conclusions During the pandemic, a perceptible worsening in patient safety perceived by patients treated in Primary Care has been observed, which has differentially affected patients according to their sociodemographic characteristics or health center profiles.
  

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  1.

  Castro A, Roca M, Ricci-Cabello I, García-Toro M, Riera-Serra P, Coronado-Simsic V, Pérez-Ara M, Gili M. Adherence to Lifestyle Interventions for Treatment of Adults with Depression: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2021 Dec.;18(24):13268. https://doi.org/10.3390%2Fijerph182413268

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  The aim of this systematic review was to determine the adherence to lifestyle interventions for adults with depression and to estimate the dropout rates in trials examining the impact of these interventions. A bibliographic search was conducted in PubMed, Embase, PsycINFO, the Cochrane library, and several sources of grey literature. We included randomised controlled trials examining the impact of multiple lifestyle interventions on depressive symptomatology in adults when compared to control or other active treatments. Two reviewers independently screened citations, extracted the relevant data, and assessed the risk of bias using Cochrane tools. A random effects meta-analysis of proportions was used to summarise the proportion of participants who completed the intervention and to determine the proportion of dropouts at post-treatment assessment. Multiple subgroup analyses were also carried out. We identified six trials. The meta-analysis of proportions showed that 53% (95%CI 49% to 58%) of the participants assigned to the intervention group fully adhered to the intervention program. The weighted mean proportion of completed intervention sessions was 66%. The pooled trial dropout rate was 22% (95%CI 20% to 24%). Around half of adults with depression adhere to lifestyle interventions. Future research is needed to develop interventions to support adherence to lifestyle interventions in depressive patients.

  @article{Castro_2021,
  abstract = {The aim of this systematic review was to determine the adherence to lifestyle interventions for adults with depression and to estimate the dropout rates in trials examining the impact of these interventions. A bibliographic search was conducted in PubMed, Embase, PsycINFO, the Cochrane library, and several sources of grey literature. We included randomised controlled trials examining the impact of multiple lifestyle interventions on depressive symptomatology in adults when compared to control or other active treatments. Two reviewers independently screened citations, extracted the relevant data, and assessed the risk of bias using Cochrane tools. A random effects meta-analysis of proportions was used to summarise the proportion of participants who completed the intervention and to determine the proportion of dropouts at post-treatment assessment. Multiple subgroup analyses were also carried out. We identified six trials. The meta-analysis of proportions showed that 53% (95%CI 49% to 58%) of the participants assigned to the intervention group fully adhered to the intervention program. The weighted mean proportion of completed intervention sessions was 66%. The pooled trial dropout rate was 22% (95%CI 20% to 24%). Around half of adults with depression adhere to lifestyle interventions. Future research is needed to develop interventions to support adherence to lifestyle interventions in depressive patients.},
  author = {Castro, A. and Roca, M. and Ricci-Cabello, I. and García-Toro, M. and Riera-Serra, P. and Coronado-Simsic, V. and Pérez-Ara, MÁ and Gili, M.},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib myown},
  month = {dec},
  number = 24,
  pages = 13268,
  publisher = {MDPI AG},
  title = {Adherence to Lifestyle Interventions for Treatment of Adults with Depression: A Systematic Review and Meta-Analysis},
  volume = 18,
  year = 2021
  }
  

  %0 Journal Article
  %1 Castro_2021
  %A Castro, A.
  %A Roca, M.
  %A Ricci-Cabello, I.
  %A García-Toro, M.
  %A Riera-Serra, P.
  %A Coronado-Simsic, V.
  %A Pérez-Ara, MÁ
  %A Gili, M.
  %D 2021
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 24
  %P 13268
  %R 10.3390/ijerph182413268
  %T Adherence to Lifestyle Interventions for Treatment of Adults with Depression: A Systematic Review and Meta-Analysis
  %U https://doi.org/10.3390%2Fijerph182413268
  %V 18
  %X The aim of this systematic review was to determine the adherence to lifestyle interventions for adults with depression and to estimate the dropout rates in trials examining the impact of these interventions. A bibliographic search was conducted in PubMed, Embase, PsycINFO, the Cochrane library, and several sources of grey literature. We included randomised controlled trials examining the impact of multiple lifestyle interventions on depressive symptomatology in adults when compared to control or other active treatments. Two reviewers independently screened citations, extracted the relevant data, and assessed the risk of bias using Cochrane tools. A random effects meta-analysis of proportions was used to summarise the proportion of participants who completed the intervention and to determine the proportion of dropouts at post-treatment assessment. Multiple subgroup analyses were also carried out. We identified six trials. The meta-analysis of proportions showed that 53% (95%CI 49% to 58%) of the participants assigned to the intervention group fully adhered to the intervention program. The weighted mean proportion of completed intervention sessions was 66%. The pooled trial dropout rate was 22% (95%CI 20% to 24%). Around half of adults with depression adhere to lifestyle interventions. Future research is needed to develop interventions to support adherence to lifestyle interventions in depressive patients.
  

• 
  1.

  del Carmen Carrascosa M, Navas A, Artigues C, Ortas S, Portells E, Soler A, Bennasar-Veny M, Leiva A. Effect of aerobic water exercise during pregnancy on epidural use and pain: A multi-centre, randomised, controlled trial. Midwifery [Internet]. 2021;103:103105. https://www.sciencedirect.com/science/article/pii/S0266613821001856

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Objective The physical and psychological benefits of exercise during pregnancy are well established. However, the impact of exercise on pain during labour and the use of epidural analgesia has been less explored. The main aim of this study was to analyse the effectiveness and safety of moderate aerobic water exercise by pregnant women on the subsequent use of epidural analgesia during labour, induction of labour, mode of delivery, and pain perception. Design A multi-centre, parallel, randomised, evaluator blinded, controlled trial in a primary care setting. Setting Primary care centres in a health district of a tertiary obstetric metropolitan hospital in Mallorca, Spain. Participants Pregnant women (14 to 20 weeks’ gestation) who had low risk of complications. Methods Three hundred and twenty pregnant women were randomly assigned to two groups: women who practiced moderate aquatic aerobic exercise with usual antenatal care, and those who received usual prenatal care alone. The gynaecologist, anaesthesiologist and midwife who assisted the women during labour were blinded to group allocations. Principal outcome: use of epidural analgesia during labour. Other outcomes: use of epidural analgesia before 6 cm cervical dilation, labour pain, type of delivery, time of active labour, episiotomy or perineal tear, and induction of labour. Results The exercise program did not affect the use of epidural analgesia (OR = 0.79, 95% CI = 0.44 to 1.40), vaginal delivery (OR = 1.35, 95% CI = 0.73 to 2.41), or caesarean section (OR = 0.94, 95% CI = 0.47 to 1.89). However, women in the exercise group reported less pain during labour (mean difference: –0.6, 95% CI = –1.11 to –0.09). The two groups (moderate aquatic aerobic exercise versus usual antenatal care) showed no significant differences in maternal or newborn adverse events. Conclusion Aquatic aerobic exercise during pregnancy had no effect on the use of epidural analgesia during labour, whereas pain perception was lower after aquatic exercise compared to usual care in pregnancy. The intervention was safe for pregnant women and their newborns.

  @article{CARRASCOSA2021103105,
  abstract = {Objective The physical and psychological benefits of exercise during pregnancy are well established. However, the impact of exercise on pain during labour and the use of epidural analgesia has been less explored. The main aim of this study was to analyse the effectiveness and safety of moderate aerobic water exercise by pregnant women on the subsequent use of epidural analgesia during labour, induction of labour, mode of delivery, and pain perception. Design A multi-centre, parallel, randomised, evaluator blinded, controlled trial in a primary care setting. Setting Primary care centres in a health district of a tertiary obstetric metropolitan hospital in Mallorca, Spain. Participants Pregnant women (14 to 20 weeks’ gestation) who had low risk of complications. Methods Three hundred and twenty pregnant women were randomly assigned to two groups: women who practiced moderate aquatic aerobic exercise with usual antenatal care, and those who received usual prenatal care alone. The gynaecologist, anaesthesiologist and midwife who assisted the women during labour were blinded to group allocations. Principal outcome: use of epidural analgesia during labour. Other outcomes: use of epidural analgesia before 6 cm cervical dilation, labour pain, type of delivery, time of active labour, episiotomy or perineal tear, and induction of labour. Results The exercise program did not affect the use of epidural analgesia (OR = 0.79, 95% CI = 0.44 to 1.40), vaginal delivery (OR = 1.35, 95% CI = 0.73 to 2.41), or caesarean section (OR = 0.94, 95% CI = 0.47 to 1.89). However, women in the exercise group reported less pain during labour (mean difference: –0.6, 95% CI = –1.11 to –0.09). The two groups (moderate aquatic aerobic exercise versus usual antenatal care) showed no significant differences in maternal or newborn adverse events. Conclusion Aquatic aerobic exercise during pregnancy had no effect on the use of epidural analgesia during labour, whereas pain perception was lower after aquatic exercise compared to usual care in pregnancy. The intervention was safe for pregnant women and their newborns.},
  author = {del Carmen Carrascosa, María and Navas, Araceli and Artigues, Catalina and Ortas, Silvia and Portells, Elena and Soler, Aina and Bennasar-Veny, Miquel and Leiva, Alfonso},
  journal = {Midwifery},
  keywords = {grapp-caib},
  pages = 103105,
  title = {Effect of aerobic water exercise during pregnancy on epidural use and pain: A multi-centre, randomised, controlled trial},
  volume = 103,
  year = 2021
  }
  

  %0 Journal Article
  %1 CARRASCOSA2021103105
  %A del Carmen Carrascosa, María
  %A Navas, Araceli
  %A Artigues, Catalina
  %A Ortas, Silvia
  %A Portells, Elena
  %A Soler, Aina
  %A Bennasar-Veny, Miquel
  %A Leiva, Alfonso
  %D 2021
  %J Midwifery
  %P 103105
  %R https://doi.org/10.1016/j.midw.2021.103105
  %T Effect of aerobic water exercise during pregnancy on epidural use and pain: A multi-centre, randomised, controlled trial
  %U https://www.sciencedirect.com/science/article/pii/S0266613821001856
  %V 103
  %X Objective The physical and psychological benefits of exercise during pregnancy are well established. However, the impact of exercise on pain during labour and the use of epidural analgesia has been less explored. The main aim of this study was to analyse the effectiveness and safety of moderate aerobic water exercise by pregnant women on the subsequent use of epidural analgesia during labour, induction of labour, mode of delivery, and pain perception. Design A multi-centre, parallel, randomised, evaluator blinded, controlled trial in a primary care setting. Setting Primary care centres in a health district of a tertiary obstetric metropolitan hospital in Mallorca, Spain. Participants Pregnant women (14 to 20 weeks’ gestation) who had low risk of complications. Methods Three hundred and twenty pregnant women were randomly assigned to two groups: women who practiced moderate aquatic aerobic exercise with usual antenatal care, and those who received usual prenatal care alone. The gynaecologist, anaesthesiologist and midwife who assisted the women during labour were blinded to group allocations. Principal outcome: use of epidural analgesia during labour. Other outcomes: use of epidural analgesia before 6 cm cervical dilation, labour pain, type of delivery, time of active labour, episiotomy or perineal tear, and induction of labour. Results The exercise program did not affect the use of epidural analgesia (OR = 0.79, 95% CI = 0.44 to 1.40), vaginal delivery (OR = 1.35, 95% CI = 0.73 to 2.41), or caesarean section (OR = 0.94, 95% CI = 0.47 to 1.89). However, women in the exercise group reported less pain during labour (mean difference: –0.6, 95% CI = –1.11 to –0.09). The two groups (moderate aquatic aerobic exercise versus usual antenatal care) showed no significant differences in maternal or newborn adverse events. Conclusion Aquatic aerobic exercise during pregnancy had no effect on the use of epidural analgesia during labour, whereas pain perception was lower after aquatic exercise compared to usual care in pregnancy. The intervention was safe for pregnant women and their newborns.
  

• 
  1.

  Abbate M, Fresneda S, Yañez A, Ricci-Cabello I, Galmes-Panades AM, Aguilo A, Bennasar-Veny M. Nurse-led telephone intervention for lifestyle changes on glycaemic control in people with prediabetes: Study protocol for a randomized controlled trial. J Adv Nurs. 2021;77(7):3204-17.

  AbstractBibTeXEndNoteDOIBibSonomy

  AIM: To evaluate the effectiveness of a nurse-led personalized telephone lifestyle intervention versus automated SMSs in the reduction of fasting plasma glucose in adults with prediabetes. DESIGN: The PREDIPHONE is a randomized controlled, parallel, two arms, superiority trial with 15 months of follow-up. Participants will be randomized to either the intervention group (teleconsultations) or the active control group (SMSs). METHODS: A total of 428 participants will be randomized in a 1:1 ratio to one of the two arms and followed up during 9 months. The teleconsultations group will receive nurse-led personalized advice, while the SMSs group will receive 4-5 brief SMSs a week. Participants in both groups will receive evidence-based recommendations for diet and physical activity (PA). Outcome measures will be collected at baseline, months 4 and 9 and at month 15, to evaluate post-intervention effects. DISCUSSION: Prevention of diabetes through the implementation of lifestyle interventions remains an important priority. The current pandemic situation has magnified its urgency as it heavily affected the functionality of the healthcare system. Moreover, it created the need of remotely delivering preventative interventions. This study will provide insights on the effectiveness and feasibility of a telephone-based intervention led by nurses in the amelioration of risk factors associated with diabetes. IMPACT: Findings from this study will offer health services decision-makers sound evidence regarding an alternative method to face-to-face consultations that could be practical, acceptable and inexpensive, and that concretely answers the need for easily implementable prevention strategies. TRIAL REGISTRATION: NCT04735640 (ClinicalTrials.gov identifier). PROTOCOL VERSION: V1.0, 18/02/2021.

  @article{RN154,
  abstract = {AIM: To evaluate the effectiveness of a nurse-led personalized telephone lifestyle intervention versus automated SMSs in the reduction of fasting plasma glucose in adults with prediabetes. DESIGN: The PREDIPHONE is a randomized controlled, parallel, two arms, superiority trial with 15 months of follow-up. Participants will be randomized to either the intervention group (teleconsultations) or the active control group (SMSs). METHODS: A total of 428 participants will be randomized in a 1:1 ratio to one of the two arms and followed up during 9 months. The teleconsultations group will receive nurse-led personalized advice, while the SMSs group will receive 4-5 brief SMSs a week. Participants in both groups will receive evidence-based recommendations for diet and physical activity (PA). Outcome measures will be collected at baseline, months 4 and 9 and at month 15, to evaluate post-intervention effects. DISCUSSION: Prevention of diabetes through the implementation of lifestyle interventions remains an important priority. The current pandemic situation has magnified its urgency as it heavily affected the functionality of the healthcare system. Moreover, it created the need of remotely delivering preventative interventions. This study will provide insights on the effectiveness and feasibility of a telephone-based intervention led by nurses in the amelioration of risk factors associated with diabetes. IMPACT: Findings from this study will offer health services decision-makers sound evidence regarding an alternative method to face-to-face consultations that could be practical, acceptable and inexpensive, and that concretely answers the need for easily implementable prevention strategies. TRIAL REGISTRATION: NCT04735640 (ClinicalTrials.gov identifier). PROTOCOL VERSION: V1.0, 18/02/2021.},
  author = {Abbate, M. and Fresneda, S. and Yañez, A. and Ricci-Cabello, I. and Galmes-Panades, A. M. and Aguilo, A. and Bennasar-Veny, M.},
  journal = {J Adv Nurs},
  keywords = {grapp-caib myown},
  number = 7,
  pages = {3204-3217},
  title = {Nurse-led telephone intervention for lifestyle changes on glycaemic control in people with prediabetes: Study protocol for a randomized controlled trial},
  type = {Journal Article},
  volume = 77,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN154
  %A Abbate, M.
  %A Fresneda, S.
  %A Yañez, A.
  %A Ricci-Cabello, I.
  %A Galmes-Panades, A. M.
  %A Aguilo, A.
  %A Bennasar-Veny, M.
  %D 2021
  %J J Adv Nurs
  %N 7
  %P 3204-3217
  %R 10.1111/jan.14842
  %T Nurse-led telephone intervention for lifestyle changes on glycaemic control in people with prediabetes: Study protocol for a randomized controlled trial
  %V 77
  %X AIM: To evaluate the effectiveness of a nurse-led personalized telephone lifestyle intervention versus automated SMSs in the reduction of fasting plasma glucose in adults with prediabetes. DESIGN: The PREDIPHONE is a randomized controlled, parallel, two arms, superiority trial with 15 months of follow-up. Participants will be randomized to either the intervention group (teleconsultations) or the active control group (SMSs). METHODS: A total of 428 participants will be randomized in a 1:1 ratio to one of the two arms and followed up during 9 months. The teleconsultations group will receive nurse-led personalized advice, while the SMSs group will receive 4-5 brief SMSs a week. Participants in both groups will receive evidence-based recommendations for diet and physical activity (PA). Outcome measures will be collected at baseline, months 4 and 9 and at month 15, to evaluate post-intervention effects. DISCUSSION: Prevention of diabetes through the implementation of lifestyle interventions remains an important priority. The current pandemic situation has magnified its urgency as it heavily affected the functionality of the healthcare system. Moreover, it created the need of remotely delivering preventative interventions. This study will provide insights on the effectiveness and feasibility of a telephone-based intervention led by nurses in the amelioration of risk factors associated with diabetes. IMPACT: Findings from this study will offer health services decision-makers sound evidence regarding an alternative method to face-to-face consultations that could be practical, acceptable and inexpensive, and that concretely answers the need for easily implementable prevention strategies. TRIAL REGISTRATION: NCT04735640 (ClinicalTrials.gov identifier). PROTOCOL VERSION: V1.0, 18/02/2021.
  

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  1.

  Bulilete O, Lorente P, Leiva A, Carandell E, Oliver A, Rojo E, Pericas P, Llobera J. Panbio™ rapid antigen test for SARS-CoV-2 has acceptable accuracy in symptomatic patients in primary health care. Journal of Infection [Internet]. 2021;82(3):391-8. https://www.sciencedirect.com/science/article/pii/S0163445321000803

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Summary Objectives We aimed to evaluate the accuracy of the Panbio™ Ag-RDT at primary health care (PHC) centers and test sites in symptomatic patients and close contacts, using the Reverse-Transcription Polymerase Chain Reaction (RT-PCR) test as the gold standard. Methods The study was conducted in four PHC centers and two test sites in Mallorca, Spain. Consecutive patients older than 18 years, attending the sites for RT-PCR testing were included. Two nasopharyngeal samples were collected, one for RT-PCR and the other was processed on-site using the Panbio™ rapid antigen test kit for SARS-CoV-2. The sensitivity and specificity were calculated using RT-PCR as the reference, and the predictive values using the pretest probability results for each analyzed group. Findings A total of 1369 participants were included; mean age 42.5 ± 14.9 years and 54.3% women. The overall prevalence was 10.2%. Most participants (70.6%) presented within 5 days of the onset of symptoms. The overall sensitivity was of 71.4% (95% CI: 63.1%, 78.7%), the specificity of 99.8% (95% CI: 99.4%, 99.9%), the positive predictive value of 98.0% (95% CI: 93.0%, 99.7%) and a negative predictive value of 96.8% (95% CI: 95.7%, 97.7%). The sensitivity was higher in symptomatic patients, in those arriving within 5 days since symptom onset and in those with high viral load. Interpretation Ag-RDT had relatively good performance characteristics in suspected symptomatic patients within five days since the onset of symptoms. However, our data do not support the sole use of Panbio™ Ag-RDT in asymptomatic individuals. Funding None

  @article{BULILETE2021391,
  abstract = {Summary Objectives We aimed to evaluate the accuracy of the Panbio™ Ag-RDT at primary health care (PHC) centers and test sites in symptomatic patients and close contacts, using the Reverse-Transcription Polymerase Chain Reaction (RT-PCR) test as the gold standard. Methods The study was conducted in four PHC centers and two test sites in Mallorca, Spain. Consecutive patients older than 18 years, attending the sites for RT-PCR testing were included. Two nasopharyngeal samples were collected, one for RT-PCR and the other was processed on-site using the Panbio™ rapid antigen test kit for SARS-CoV-2. The sensitivity and specificity were calculated using RT-PCR as the reference, and the predictive values using the pretest probability results for each analyzed group. Findings A total of 1369 participants were included; mean age 42.5 ± 14.9 years and 54.3% women. The overall prevalence was 10.2%. Most participants (70.6%) presented within 5 days of the onset of symptoms. The overall sensitivity was of 71.4% (95% CI: 63.1%, 78.7%), the specificity of 99.8% (95% CI: 99.4%, 99.9%), the positive predictive value of 98.0% (95% CI: 93.0%, 99.7%) and a negative predictive value of 96.8% (95% CI: 95.7%, 97.7%). The sensitivity was higher in symptomatic patients, in those arriving within 5 days since symptom onset and in those with high viral load. Interpretation Ag-RDT had relatively good performance characteristics in suspected symptomatic patients within five days since the onset of symptoms. However, our data do not support the sole use of Panbio™ Ag-RDT in asymptomatic individuals. Funding None},
  author = {Bulilete, Oana and Lorente, Patricia and Leiva, Alfonso and Carandell, Eugenia and Oliver, Antonio and Rojo, Estrella and Pericas, Pau and Llobera, Joan},
  journal = {Journal of Infection},
  keywords = {grapp-caib},
  number = 3,
  pages = {391-398},
  title = {Panbio™ rapid antigen test for SARS-CoV-2 has acceptable accuracy in symptomatic patients in primary health care},
  volume = 82,
  year = 2021
  }
  

  %0 Journal Article
  %1 BULILETE2021391
  %A Bulilete, Oana
  %A Lorente, Patricia
  %A Leiva, Alfonso
  %A Carandell, Eugenia
  %A Oliver, Antonio
  %A Rojo, Estrella
  %A Pericas, Pau
  %A Llobera, Joan
  %D 2021
  %J Journal of Infection
  %N 3
  %P 391-398
  %R https://doi.org/10.1016/j.jinf.2021.02.014
  %T Panbio™ rapid antigen test for SARS-CoV-2 has acceptable accuracy in symptomatic patients in primary health care
  %U https://www.sciencedirect.com/science/article/pii/S0163445321000803
  %V 82
  %X Summary Objectives We aimed to evaluate the accuracy of the Panbio™ Ag-RDT at primary health care (PHC) centers and test sites in symptomatic patients and close contacts, using the Reverse-Transcription Polymerase Chain Reaction (RT-PCR) test as the gold standard. Methods The study was conducted in four PHC centers and two test sites in Mallorca, Spain. Consecutive patients older than 18 years, attending the sites for RT-PCR testing were included. Two nasopharyngeal samples were collected, one for RT-PCR and the other was processed on-site using the Panbio™ rapid antigen test kit for SARS-CoV-2. The sensitivity and specificity were calculated using RT-PCR as the reference, and the predictive values using the pretest probability results for each analyzed group. Findings A total of 1369 participants were included; mean age 42.5 ± 14.9 years and 54.3% women. The overall prevalence was 10.2%. Most participants (70.6%) presented within 5 days of the onset of symptoms. The overall sensitivity was of 71.4% (95% CI: 63.1%, 78.7%), the specificity of 99.8% (95% CI: 99.4%, 99.9%), the positive predictive value of 98.0% (95% CI: 93.0%, 99.7%) and a negative predictive value of 96.8% (95% CI: 95.7%, 97.7%). The sensitivity was higher in symptomatic patients, in those arriving within 5 days since symptom onset and in those with high viral load. Interpretation Ag-RDT had relatively good performance characteristics in suspected symptomatic patients within five days since the onset of symptoms. However, our data do not support the sole use of Panbio™ Ag-RDT in asymptomatic individuals. Funding None
  

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  1.

  Gil-Girbau M, Pons-Vigués M, Rubio-Valera M, Murrugarra G, Masluk B, Rodríguez-Martín B, García Pineda A, Vidal Thomás C, Conejo-Cerón S, Recio JI, Martínez C, Pujol-Ribera E, Berenguera A. Modelos teóricos de promoción de la salud en la práctica habitual en atención primaria de salud. Gaceta Sanitaria [Internet]. 2021;35(1):48-59. https://www.sciencedirect.com/science/article/pii/S0213911119302158

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Resumen Objetivo Comprender a qué modelos teóricos se ajusta la práctica actual de la prevención primaria y promoción de la salud en atención primaria de salud en diferentes centros de salud de siete comunidades autónomas de España, según los/las profesionales de distintas disciplinas de este ámbito asistencial. Método Investigación cualitativa descriptiva en la que participaron 145 profesionales de 14 centros de salud de siete comunidades autónomas de España. El muestreo fue teórico. Se realizaron 14 grupos de discusión. El análisis de datos se realizó siguiendo procedimientos del análisis de contenido temático y de acuerdo con siete modelos teóricos de promoción de la salud a nivel micro, meso y macro. Resultados Las prácticas de los profesionales de los centros participantes en relación con las actividades de prevención primaria y promoción de la salud se adhieren principalmente a modelos intrapersonales, centrándose en ayudar a que las personas se empoderen aumentando la conciencia de riesgo y de los beneficios del cambio en los comportamientos, y guiándolas en la implementación de un comportamiento saludable. Algunos/as profesionales realizan actividades que encajan en modelos interpersonales, implicando a la familia y al propio profesional en las estrategias. Solo en algunos casos las prácticas actuales encajan en modelos comunitarios de promoción de la salud. Conclusiones Las prácticas de prevención primaria y promoción de la salud de los profesionales de atención primaria siguen principalmente modelos intrapersonales, en algunos casos modelos interpersonales y más puntualmente modelos comunitarios. Es necesario potenciar la participación de la ciudadanía y la orientación comunitaria de los servicios de atención primaria de salud. Objective To understand which theoretical models apply to current primary care practice of primary prevention and health promotion in a sample of primary health centres of seven autonomous regions in Spain according to the various professionals involved. Method Descriptive qualitative research with the participation of 145 professionals from 14 primary health centres of seven autonomous regions in Spain. Theoretical sampling was used and 14 discussion groups were carried out. Data analysis followed thematic contents analysis procedures and was based on seven health promotion theoretical models at micro-, meso- and macro-level. Results Current practice of primary prevention and health promotion activities mainly follow intrapersonal models, which focus on assisting the empowerment of patients by means of raising awareness of risk and benefits of behavioural change and on guiding the adoption of the new healthy behaviour. To a lesser degree, the activities of some professionals adhere to interpersonal models, which involve also the family and the health professional. In only a few instances community models of health promotion were used. Conclusions Primary prevention and health promotion practice of primary healthcare professionals follow mainly intrapersonal models, few cases use interpersonal models and community models are only occasionally employed. Advance of public participation and community orientation in primary healthcare services is needed.

  @article{GILGIRBAU202148,
  abstract = {Resumen Objetivo Comprender a qué modelos teóricos se ajusta la práctica actual de la prevención primaria y promoción de la salud en atención primaria de salud en diferentes centros de salud de siete comunidades autónomas de España, según los/las profesionales de distintas disciplinas de este ámbito asistencial. Método Investigación cualitativa descriptiva en la que participaron 145 profesionales de 14 centros de salud de siete comunidades autónomas de España. El muestreo fue teórico. Se realizaron 14 grupos de discusión. El análisis de datos se realizó siguiendo procedimientos del análisis de contenido temático y de acuerdo con siete modelos teóricos de promoción de la salud a nivel micro, meso y macro. Resultados Las prácticas de los profesionales de los centros participantes en relación con las actividades de prevención primaria y promoción de la salud se adhieren principalmente a modelos intrapersonales, centrándose en ayudar a que las personas se empoderen aumentando la conciencia de riesgo y de los beneficios del cambio en los comportamientos, y guiándolas en la implementación de un comportamiento saludable. Algunos/as profesionales realizan actividades que encajan en modelos interpersonales, implicando a la familia y al propio profesional en las estrategias. Solo en algunos casos las prácticas actuales encajan en modelos comunitarios de promoción de la salud. Conclusiones Las prácticas de prevención primaria y promoción de la salud de los profesionales de atención primaria siguen principalmente modelos intrapersonales, en algunos casos modelos interpersonales y más puntualmente modelos comunitarios. Es necesario potenciar la participación de la ciudadanía y la orientación comunitaria de los servicios de atención primaria de salud. Objective To understand which theoretical models apply to current primary care practice of primary prevention and health promotion in a sample of primary health centres of seven autonomous regions in Spain according to the various professionals involved. Method Descriptive qualitative research with the participation of 145 professionals from 14 primary health centres of seven autonomous regions in Spain. Theoretical sampling was used and 14 discussion groups were carried out. Data analysis followed thematic contents analysis procedures and was based on seven health promotion theoretical models at micro-, meso- and macro-level. Results Current practice of primary prevention and health promotion activities mainly follow intrapersonal models, which focus on assisting the empowerment of patients by means of raising awareness of risk and benefits of behavioural change and on guiding the adoption of the new healthy behaviour. To a lesser degree, the activities of some professionals adhere to interpersonal models, which involve also the family and the health professional. In only a few instances community models of health promotion were used. Conclusions Primary prevention and health promotion practice of primary healthcare professionals follow mainly intrapersonal models, few cases use interpersonal models and community models are only occasionally employed. Advance of public participation and community orientation in primary healthcare services is needed.},
  author = {Gil-Girbau, Montse and Pons-Vigués, Mariona and Rubio-Valera, Maria and Murrugarra, Gabriela and Masluk, Barbara and Rodríguez-Martín, Beatriz and García Pineda, Atanasio and Vidal Thomás, Clara and Conejo-Cerón, Sonia and Recio, José Ignacio and Martínez, Catalina and Pujol-Ribera, Enriqueta and Berenguera, Anna},
  journal = {Gaceta Sanitaria},
  keywords = {grapp-caib},
  number = 1,
  pages = {48-59},
  title = {Modelos teóricos de promoción de la salud en la práctica habitual en atención primaria de salud},
  volume = 35,
  year = 2021
  }
  

  %0 Journal Article
  %1 GILGIRBAU202148
  %A Gil-Girbau, Montse
  %A Pons-Vigués, Mariona
  %A Rubio-Valera, Maria
  %A Murrugarra, Gabriela
  %A Masluk, Barbara
  %A Rodríguez-Martín, Beatriz
  %A García Pineda, Atanasio
  %A Vidal Thomás, Clara
  %A Conejo-Cerón, Sonia
  %A Recio, José Ignacio
  %A Martínez, Catalina
  %A Pujol-Ribera, Enriqueta
  %A Berenguera, Anna
  %D 2021
  %J Gaceta Sanitaria
  %N 1
  %P 48-59
  %R https://doi.org/10.1016/j.gaceta.2019.06.011
  %T Modelos teóricos de promoción de la salud en la práctica habitual en atención primaria de salud
  %U https://www.sciencedirect.com/science/article/pii/S0213911119302158
  %V 35
  %X Resumen Objetivo Comprender a qué modelos teóricos se ajusta la práctica actual de la prevención primaria y promoción de la salud en atención primaria de salud en diferentes centros de salud de siete comunidades autónomas de España, según los/las profesionales de distintas disciplinas de este ámbito asistencial. Método Investigación cualitativa descriptiva en la que participaron 145 profesionales de 14 centros de salud de siete comunidades autónomas de España. El muestreo fue teórico. Se realizaron 14 grupos de discusión. El análisis de datos se realizó siguiendo procedimientos del análisis de contenido temático y de acuerdo con siete modelos teóricos de promoción de la salud a nivel micro, meso y macro. Resultados Las prácticas de los profesionales de los centros participantes en relación con las actividades de prevención primaria y promoción de la salud se adhieren principalmente a modelos intrapersonales, centrándose en ayudar a que las personas se empoderen aumentando la conciencia de riesgo y de los beneficios del cambio en los comportamientos, y guiándolas en la implementación de un comportamiento saludable. Algunos/as profesionales realizan actividades que encajan en modelos interpersonales, implicando a la familia y al propio profesional en las estrategias. Solo en algunos casos las prácticas actuales encajan en modelos comunitarios de promoción de la salud. Conclusiones Las prácticas de prevención primaria y promoción de la salud de los profesionales de atención primaria siguen principalmente modelos intrapersonales, en algunos casos modelos interpersonales y más puntualmente modelos comunitarios. Es necesario potenciar la participación de la ciudadanía y la orientación comunitaria de los servicios de atención primaria de salud. Objective To understand which theoretical models apply to current primary care practice of primary prevention and health promotion in a sample of primary health centres of seven autonomous regions in Spain according to the various professionals involved. Method Descriptive qualitative research with the participation of 145 professionals from 14 primary health centres of seven autonomous regions in Spain. Theoretical sampling was used and 14 discussion groups were carried out. Data analysis followed thematic contents analysis procedures and was based on seven health promotion theoretical models at micro-, meso- and macro-level. Results Current practice of primary prevention and health promotion activities mainly follow intrapersonal models, which focus on assisting the empowerment of patients by means of raising awareness of risk and benefits of behavioural change and on guiding the adoption of the new healthy behaviour. To a lesser degree, the activities of some professionals adhere to interpersonal models, which involve also the family and the health professional. In only a few instances community models of health promotion were used. Conclusions Primary prevention and health promotion practice of primary healthcare professionals follow mainly intrapersonal models, few cases use interpersonal models and community models are only occasionally employed. Advance of public participation and community orientation in primary healthcare services is needed.
  

• 
  1.

  Socias I, Leiva A, Pombo-Ramos H, Bejarano F, Sempere-Verdú E, Rodr’iguez-Rincón RM, Fiol F, Mengual M, Ajenjo-Navarro A, Pazo FD, Mateu C, Folch S, Alegret S, Coll JM, Mart’in-Rabadán M, Vicens C. Evaluating the Implementation of a Multicomponent Intervention Consisting of Education and Feedback on Reducing Benzodiazepine Prescriptions by General Practitioners: BENZORED Hybrid Type I Cluster Randomized Controlled Trial. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2021 Jul.;18(15):7964. https://doi.org/10.3390%2Fijerph18157964

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: General practitioners (GPs) in developed countries widely prescribe benzodiazepines (BZDs) for their anxiolytic, hypnotic, and muscle-relaxant effects. Treatment duration, however, is rarely limited, and this results in a significant number of chronic users. Long-term BZD use is associated with cognitive impairment, falls with hip fractures, traffic accidents, and increased mortality. The BENZORED IV trial was a hybrid type-1 trial conducted to evaluate the effectiveness and implementation of an intervention to reduce BZD prescription in primary care. The purpose of this qualitative study was to analyze the facilitators and barriers regarding the implementation of the intervention in primary care settings. METHODS: A qualitative interview study with 40 GPs from three Spanish health districts. Focus group meetings with GPs from the intervention arm of the BENZORED IV trial were held at primary healthcare centers in the three districts. For sampling purposes, the GPs were classified as high or low implementers according to the success of the intervention measured at 12 months. The Consolidated Framework for Implementation Research (CFIR) was used to conduct the meetings and to code, rate, and analyze the data. RESULTS: Three of the 41 CFIR constructs strongly distinguished between high and low implementers: the complexity of the intervention, the individual Stage of Change, and the key stakeholder's engagement. Seven constructs weakly discriminated between the two groups: adaptability in the intervention, external policy and incentives, implementation climate, relative priority, self-efficacy, compatibility, and engaging a formally appointed implementation leader. Fourteen constructs did not discriminate between the two groups, six had insufficient data for evaluation, and eleven had no data for evaluation. CONCLUSIONS: We identified constructs that could explain differences in the efficacy in implementation of the intervention. This information is relevant for the design of successful strategies for implementation of the intervention.

  @article{Socias_2021,
  abstract = {BACKGROUND: General practitioners (GPs) in developed countries widely prescribe benzodiazepines (BZDs) for their anxiolytic, hypnotic, and muscle-relaxant effects. Treatment duration, however, is rarely limited, and this results in a significant number of chronic users. Long-term BZD use is associated with cognitive impairment, falls with hip fractures, traffic accidents, and increased mortality. The BENZORED IV trial was a hybrid type-1 trial conducted to evaluate the effectiveness and implementation of an intervention to reduce BZD prescription in primary care. The purpose of this qualitative study was to analyze the facilitators and barriers regarding the implementation of the intervention in primary care settings. METHODS: A qualitative interview study with 40 GPs from three Spanish health districts. Focus group meetings with GPs from the intervention arm of the BENZORED IV trial were held at primary healthcare centers in the three districts. For sampling purposes, the GPs were classified as high or low implementers according to the success of the intervention measured at 12 months. The Consolidated Framework for Implementation Research (CFIR) was used to conduct the meetings and to code, rate, and analyze the data. RESULTS: Three of the 41 CFIR constructs strongly distinguished between high and low implementers: the complexity of the intervention, the individual Stage of Change, and the key stakeholder's engagement. Seven constructs weakly discriminated between the two groups: adaptability in the intervention, external policy and incentives, implementation climate, relative priority, self-efficacy, compatibility, and engaging a formally appointed implementation leader. Fourteen constructs did not discriminate between the two groups, six had insufficient data for evaluation, and eleven had no data for evaluation. CONCLUSIONS: We identified constructs that could explain differences in the efficacy in implementation of the intervention. This information is relevant for the design of successful strategies for implementation of the intervention.},
  author = {Socias, Isabel and Leiva, Alfonso and Pombo-Ramos, Haizea and Bejarano, Ferran and Sempere-Verdú, Ermengol and Rodr'iguez-Rincón, Raquel Mar'ia and Fiol, Francisca and Mengual, Marta and Ajenjo-Navarro, Asunción and Pazo, Fernando Do and Mateu, Catalina and Folch, Silvia and Alegret, Santiago and Coll, Jose Maria and Mart'in-Rabadán, Mar'ia and Vicens, Caterina},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {jul},
  number = 15,
  pages = 7964,
  publisher = {MDPI AG},
  title = {Evaluating the Implementation of a Multicomponent Intervention Consisting of Education and Feedback on Reducing Benzodiazepine Prescriptions by General Practitioners: BENZORED Hybrid Type I Cluster Randomized Controlled Trial},
  volume = 18,
  year = 2021
  }
  

  %0 Journal Article
  %1 Socias_2021
  %A Socias, Isabel
  %A Leiva, Alfonso
  %A Pombo-Ramos, Haizea
  %A Bejarano, Ferran
  %A Sempere-Verdú, Ermengol
  %A Rodr'iguez-Rincón, Raquel Mar'ia
  %A Fiol, Francisca
  %A Mengual, Marta
  %A Ajenjo-Navarro, Asunción
  %A Pazo, Fernando Do
  %A Mateu, Catalina
  %A Folch, Silvia
  %A Alegret, Santiago
  %A Coll, Jose Maria
  %A Mart'in-Rabadán, Mar'ia
  %A Vicens, Caterina
  %D 2021
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 15
  %P 7964
  %R 10.3390/ijerph18157964
  %T Evaluating the Implementation of a Multicomponent Intervention Consisting of Education and Feedback on Reducing Benzodiazepine Prescriptions by General Practitioners: BENZORED Hybrid Type I Cluster Randomized Controlled Trial
  %U https://doi.org/10.3390%2Fijerph18157964
  %V 18
  %X BACKGROUND: General practitioners (GPs) in developed countries widely prescribe benzodiazepines (BZDs) for their anxiolytic, hypnotic, and muscle-relaxant effects. Treatment duration, however, is rarely limited, and this results in a significant number of chronic users. Long-term BZD use is associated with cognitive impairment, falls with hip fractures, traffic accidents, and increased mortality. The BENZORED IV trial was a hybrid type-1 trial conducted to evaluate the effectiveness and implementation of an intervention to reduce BZD prescription in primary care. The purpose of this qualitative study was to analyze the facilitators and barriers regarding the implementation of the intervention in primary care settings. METHODS: A qualitative interview study with 40 GPs from three Spanish health districts. Focus group meetings with GPs from the intervention arm of the BENZORED IV trial were held at primary healthcare centers in the three districts. For sampling purposes, the GPs were classified as high or low implementers according to the success of the intervention measured at 12 months. The Consolidated Framework for Implementation Research (CFIR) was used to conduct the meetings and to code, rate, and analyze the data. RESULTS: Three of the 41 CFIR constructs strongly distinguished between high and low implementers: the complexity of the intervention, the individual Stage of Change, and the key stakeholder's engagement. Seven constructs weakly discriminated between the two groups: adaptability in the intervention, external policy and incentives, implementation climate, relative priority, self-efficacy, compatibility, and engaging a formally appointed implementation leader. Fourteen constructs did not discriminate between the two groups, six had insufficient data for evaluation, and eleven had no data for evaluation. CONCLUSIONS: We identified constructs that could explain differences in the efficacy in implementation of the intervention. This information is relevant for the design of successful strategies for implementation of the intervention.
  

• 
  1.

  Oliván-Blázquez B, Aguilar-Latorre A, Motrico E, Gómez-Gómez I, Zabaleta-Del-Olmo E, Couso-Viana S, Clavería A, Maderuelo-Fernandez JA, Recio-Rodríguez JI, Moreno-Peral P, Casajuana-Closas M, López-Jiménez T, Bolíbar B, Llobera J, Sarasa-Bosque C, Sanchez-Perez Á, Bellón J, Magallón-Botaya R. The Relationship between Adherence to the Mediterranean Diet, Intake of Specific Foods and Depression in an Adult Population (45\textendash75 Years) in Primary Health Care. A Cross-Sectional Descriptive Study. Nutrients [Internet]. MDPI AG; 2021 Aug.;13(8):2724. https://doi.org/10.3390%2Fnu13082724

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: The relationship between the quality of the diet and the adherence to the Mediterranean diet with the presence of persistent or recurrent depressive symptoms have been described. The objective of this study is to analyze the relationship between adherence to the Mediterranean diet and the intake of specific foods in primary care patients aged 45 to 75, having subclinical or major depression. The study also specifically analyzes this relationship in individuals suffering from chronic diseases. METHODS: A cross-sectional descriptive study was conducted. 3062 subjects met the inclusion criteria from the EIRA study. Sociodemographic variables, clinical morbidity, depression symptomatology (PHQ-9) and adherence to Mediterranean diet (MEDAS) were collected. RESULTS: Being female, younger, with a higher BMI, consuming more than 1 serving of red meat a day and drinking more than one carbonated or sugary drink daily, not consuming 3 servings of nuts a week and not eating 2 vegetables cooked in olive oil a week are predictors of having higher depressive symptomatology. CONCLUSIONS: Assessing the type of diet of patients presenting depressive symptoms and promoting adherence to a healthy diet is important, especially in patients with chronic diseases. However, depression is a very complex issue and the relationship between nutrition and depression must be further examined.

  @article{Oliv_n_Bl_zquez_2021,
  abstract = {BACKGROUND: The relationship between the quality of the diet and the adherence to the Mediterranean diet with the presence of persistent or recurrent depressive symptoms have been described. The objective of this study is to analyze the relationship between adherence to the Mediterranean diet and the intake of specific foods in primary care patients aged 45 to 75, having subclinical or major depression. The study also specifically analyzes this relationship in individuals suffering from chronic diseases. METHODS: A cross-sectional descriptive study was conducted. 3062 subjects met the inclusion criteria from the EIRA study. Sociodemographic variables, clinical morbidity, depression symptomatology (PHQ-9) and adherence to Mediterranean diet (MEDAS) were collected. RESULTS: Being female, younger, with a higher BMI, consuming more than 1 serving of red meat a day and drinking more than one carbonated or sugary drink daily, not consuming 3 servings of nuts a week and not eating 2 vegetables cooked in olive oil a week are predictors of having higher depressive symptomatology. CONCLUSIONS: Assessing the type of diet of patients presenting depressive symptoms and promoting adherence to a healthy diet is important, especially in patients with chronic diseases. However, depression is a very complex issue and the relationship between nutrition and depression must be further examined.},
  author = {Oliván-Blázquez, B. and Aguilar-Latorre, A. and Motrico, E. and Gómez-Gómez, I. and Zabaleta-Del-Olmo, E. and Couso-Viana, S. and Clavería, A. and Maderuelo-Fernandez, J. A. and Recio-Rodríguez, J. I. and Moreno-Peral, P. and Casajuana-Closas, M. and López-Jiménez, T. and Bolíbar, B. and Llobera, J. and Sarasa-Bosque, C. and Sanchez-Perez, Á and Bellón, JÁ and Magallón-Botaya, R.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {aug},
  number = 8,
  pages = 2724,
  publisher = {MDPI AG},
  title = {The Relationship between Adherence to the Mediterranean Diet, Intake of Specific Foods and Depression in an Adult Population (45\textendash75 Years) in Primary Health Care. A Cross-Sectional Descriptive Study},
  volume = 13,
  year = 2021
  }
  

  %0 Journal Article
  %1 Oliv_n_Bl_zquez_2021
  %A Oliván-Blázquez, B.
  %A Aguilar-Latorre, A.
  %A Motrico, E.
  %A Gómez-Gómez, I.
  %A Zabaleta-Del-Olmo, E.
  %A Couso-Viana, S.
  %A Clavería, A.
  %A Maderuelo-Fernandez, J. A.
  %A Recio-Rodríguez, J. I.
  %A Moreno-Peral, P.
  %A Casajuana-Closas, M.
  %A López-Jiménez, T.
  %A Bolíbar, B.
  %A Llobera, J.
  %A Sarasa-Bosque, C.
  %A Sanchez-Perez, Á
  %A Bellón, JÁ
  %A Magallón-Botaya, R.
  %D 2021
  %I MDPI AG
  %J Nutrients
  %N 8
  %P 2724
  %R 10.3390/nu13082724
  %T The Relationship between Adherence to the Mediterranean Diet, Intake of Specific Foods and Depression in an Adult Population (45\textendash75 Years) in Primary Health Care. A Cross-Sectional Descriptive Study
  %U https://doi.org/10.3390%2Fnu13082724
  %V 13
  %X BACKGROUND: The relationship between the quality of the diet and the adherence to the Mediterranean diet with the presence of persistent or recurrent depressive symptoms have been described. The objective of this study is to analyze the relationship between adherence to the Mediterranean diet and the intake of specific foods in primary care patients aged 45 to 75, having subclinical or major depression. The study also specifically analyzes this relationship in individuals suffering from chronic diseases. METHODS: A cross-sectional descriptive study was conducted. 3062 subjects met the inclusion criteria from the EIRA study. Sociodemographic variables, clinical morbidity, depression symptomatology (PHQ-9) and adherence to Mediterranean diet (MEDAS) were collected. RESULTS: Being female, younger, with a higher BMI, consuming more than 1 serving of red meat a day and drinking more than one carbonated or sugary drink daily, not consuming 3 servings of nuts a week and not eating 2 vegetables cooked in olive oil a week are predictors of having higher depressive symptomatology. CONCLUSIONS: Assessing the type of diet of patients presenting depressive symptoms and promoting adherence to a healthy diet is important, especially in patients with chronic diseases. However, depression is a very complex issue and the relationship between nutrition and depression must be further examined.
  

• 
  1.

  Represas-Carrera F, Couso-Viana S, Méndez-López F, Masluk B, Magallón-Botaya R, Recio-Rodr’iguez JI, Pombo H, Leiva-Rus A, Gil-Girbau M, Motrico E, Mart’i-Lluch R, Gude F, Claver’ia A. Effectiveness of a Multicomponent Intervention in Primary Care That Addresses Patients with Diabetes Mellitus with Two or More Unhealthy Habits, Such as Diet, Physical Activity or Smoking: Multicenter Randomized Cluster Trial (EIRA Study). International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2021 May;18(11):5788. https://doi.org/10.3390%2Fijerph18115788

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Introduction: We evaluated the effectiveness of an individual, group and community intervention to improve the glycemic control of patients with diabetes mellitus aged 45-75 years with two or three unhealthy life habits. As secondary endpoints, we evaluated the inverventions' effectiveness on adhering to Mediterranean diet, physical activity, sedentary lifestyle, smoking and quality of life. Method: A randomized clinical cluster (health centers) trial with two parallel groups in Spain from January 2016 to December 2019 was used. Patients with diabetes mellitus aged 45-75 years with two unhealthy life habits or more (smoking, not adhering to Mediterranean diet or little physical activity) participated. Centers were randomly assigned. The sample size was estimated to be 420 people for the main outcome variable. Educational intervention was done to improve adherence to Mediterranean diet, physical activity and smoking cessation by individual, group and community interventions for 12 months. Controls received the usual health care. The outcome variables were: HbA1c (main), the Mediterranean diet adherence score (MEDAS), the international diet quality index (DQI-I), the international physical activity questionnaire (IPAQ), sedentary lifestyle, smoking ≥1 cigarette/day and the EuroQuol questionnaire (EVA-EuroQol5D5L). Results: In total, 13 control centers (n = 356) and 12 intervention centers (n = 338) were included with similar baseline conditions. An analysis for intention-to-treat was done by applying multilevel mixed models fitted by basal values and the health center: the HbA1c adjusted mean difference = -0.09 (95% CI: -0.29-0.10), the DQI-I adjusted mean difference = 0.25 (95% CI: -0.32-0.82), the MEDAS adjusted mean difference = 0.45 (95% CI: 0.01-0.89), moderate/high physical activity OR = 1.09 (95% CI: 0.64-1.86), not living a sedentary lifestyle OR = 0.97 (95% CI: 0.55-1.73), no smoking OR = 0.61 (95% CI: 0.54-1.06), EVA adjusted mean difference = -1.26 (95% CI: -4.98-2.45). Conclusions: No statistically significant changes were found for either glycemic control or physical activity, sedentary lifestyle, smoking and quality of life. The multicomponent individual, group and community interventions only showed a statistically significant improvement in adhering to Mediterranean diet. Such innovative interventions need further research to demonstrate their effectiveness in patients with poor glycemic control.

  @article{Represas_Carrera_2021,
  abstract = {Introduction: We evaluated the effectiveness of an individual, group and community intervention to improve the glycemic control of patients with diabetes mellitus aged 45-75 years with two or three unhealthy life habits. As secondary endpoints, we evaluated the inverventions' effectiveness on adhering to Mediterranean diet, physical activity, sedentary lifestyle, smoking and quality of life. Method: A randomized clinical cluster (health centers) trial with two parallel groups in Spain from January 2016 to December 2019 was used. Patients with diabetes mellitus aged 45-75 years with two unhealthy life habits or more (smoking, not adhering to Mediterranean diet or little physical activity) participated. Centers were randomly assigned. The sample size was estimated to be 420 people for the main outcome variable. Educational intervention was done to improve adherence to Mediterranean diet, physical activity and smoking cessation by individual, group and community interventions for 12 months. Controls received the usual health care. The outcome variables were: HbA1c (main), the Mediterranean diet adherence score (MEDAS), the international diet quality index (DQI-I), the international physical activity questionnaire (IPAQ), sedentary lifestyle, smoking ≥1 cigarette/day and the EuroQuol questionnaire (EVA-EuroQol5D5L). Results: In total, 13 control centers (n = 356) and 12 intervention centers (n = 338) were included with similar baseline conditions. An analysis for intention-to-treat was done by applying multilevel mixed models fitted by basal values and the health center: the HbA1c adjusted mean difference = -0.09 (95% CI: -0.29-0.10), the DQI-I adjusted mean difference = 0.25 (95% CI: -0.32-0.82), the MEDAS adjusted mean difference = 0.45 (95% CI: 0.01-0.89), moderate/high physical activity OR = 1.09 (95% CI: 0.64-1.86), not living a sedentary lifestyle OR = 0.97 (95% CI: 0.55-1.73), no smoking OR = 0.61 (95% CI: 0.54-1.06), EVA adjusted mean difference = -1.26 (95% CI: -4.98-2.45). Conclusions: No statistically significant changes were found for either glycemic control or physical activity, sedentary lifestyle, smoking and quality of life. The multicomponent individual, group and community interventions only showed a statistically significant improvement in adhering to Mediterranean diet. Such innovative interventions need further research to demonstrate their effectiveness in patients with poor glycemic control.},
  author = {Represas-Carrera, Francisco and Couso-Viana, Sabela and Méndez-López, Fátima and Masluk, Bárbara and Magallón-Botaya, Rosa and Recio-Rodr'iguez, Jose I. and Pombo, Haizea and Leiva-Rus, Alfonso and Gil-Girbau, Montserrat and Motrico, Emma and Mart'i-Lluch, Ruth and Gude, Francisco and Claver'ia, Ana},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {may},
  number = 11,
  pages = 5788,
  publisher = {MDPI AG},
  title = {Effectiveness of a Multicomponent Intervention in Primary Care That Addresses Patients with Diabetes Mellitus with Two or More Unhealthy Habits, Such as Diet, Physical Activity or Smoking: Multicenter Randomized Cluster Trial (EIRA Study)},
  volume = 18,
  year = 2021
  }
  

  %0 Journal Article
  %1 Represas_Carrera_2021
  %A Represas-Carrera, Francisco
  %A Couso-Viana, Sabela
  %A Méndez-López, Fátima
  %A Masluk, Bárbara
  %A Magallón-Botaya, Rosa
  %A Recio-Rodr'iguez, Jose I.
  %A Pombo, Haizea
  %A Leiva-Rus, Alfonso
  %A Gil-Girbau, Montserrat
  %A Motrico, Emma
  %A Mart'i-Lluch, Ruth
  %A Gude, Francisco
  %A Claver'ia, Ana
  %D 2021
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 11
  %P 5788
  %R 10.3390/ijerph18115788
  %T Effectiveness of a Multicomponent Intervention in Primary Care That Addresses Patients with Diabetes Mellitus with Two or More Unhealthy Habits, Such as Diet, Physical Activity or Smoking: Multicenter Randomized Cluster Trial (EIRA Study)
  %U https://doi.org/10.3390%2Fijerph18115788
  %V 18
  %X Introduction: We evaluated the effectiveness of an individual, group and community intervention to improve the glycemic control of patients with diabetes mellitus aged 45-75 years with two or three unhealthy life habits. As secondary endpoints, we evaluated the inverventions' effectiveness on adhering to Mediterranean diet, physical activity, sedentary lifestyle, smoking and quality of life. Method: A randomized clinical cluster (health centers) trial with two parallel groups in Spain from January 2016 to December 2019 was used. Patients with diabetes mellitus aged 45-75 years with two unhealthy life habits or more (smoking, not adhering to Mediterranean diet or little physical activity) participated. Centers were randomly assigned. The sample size was estimated to be 420 people for the main outcome variable. Educational intervention was done to improve adherence to Mediterranean diet, physical activity and smoking cessation by individual, group and community interventions for 12 months. Controls received the usual health care. The outcome variables were: HbA1c (main), the Mediterranean diet adherence score (MEDAS), the international diet quality index (DQI-I), the international physical activity questionnaire (IPAQ), sedentary lifestyle, smoking ≥1 cigarette/day and the EuroQuol questionnaire (EVA-EuroQol5D5L). Results: In total, 13 control centers (n = 356) and 12 intervention centers (n = 338) were included with similar baseline conditions. An analysis for intention-to-treat was done by applying multilevel mixed models fitted by basal values and the health center: the HbA1c adjusted mean difference = -0.09 (95% CI: -0.29-0.10), the DQI-I adjusted mean difference = 0.25 (95% CI: -0.32-0.82), the MEDAS adjusted mean difference = 0.45 (95% CI: 0.01-0.89), moderate/high physical activity OR = 1.09 (95% CI: 0.64-1.86), not living a sedentary lifestyle OR = 0.97 (95% CI: 0.55-1.73), no smoking OR = 0.61 (95% CI: 0.54-1.06), EVA adjusted mean difference = -1.26 (95% CI: -4.98-2.45). Conclusions: No statistically significant changes were found for either glycemic control or physical activity, sedentary lifestyle, smoking and quality of life. The multicomponent individual, group and community interventions only showed a statistically significant improvement in adhering to Mediterranean diet. Such innovative interventions need further research to demonstrate their effectiveness in patients with poor glycemic control.
  

• 
  1.

  Ricci-Cabello I, Gangannagaripalli J, Mounce LTA, Valderas JM. Identifying Factors Leading to Harm in English General Practices: A Mixed-Methods Study Based on Patient Experiences Integrating Structural Equation Modeling and Qualitative Content Analysis. Journal of Patient Safety [Internet]. Ovid Technologies (Wolters Kluwer Health); 2021 Jan.;17(1):e20-e27. https://doi.org/10.1097%2Fpts.0000000000000669

  AbstractURLBibTeXEndNoteDOIBibSonomy

  OBJECTIVE: The aim of the study was to identify the main factors leading to harm in primary care based on the experiences reported by patients. METHODS: We conducted a mixed-methods, cross-sectional study in 45 primary care centers in England. A random sample of 6736 patients was invited to complete the Patient-Reported Experiences and Outcomes of Safety in Primary Care questionnaire. We fitted structural equation modeling on the quantitative data (n = 1244 respondents) to identify contributory factors and primary incidents leading to harm. We conducted content analyses of responses to seven open-ended questions (n = 386) to obtain deeper insight into patient perceptions of the causes of harm experienced. Results from quantitative and qualitative analyses were triangulated. RESULTS: Patients reported harm related to physical health (13%), pain (11%), and mental health (19%) and harm that increased limitations in social activities (14%). Physical harm was associated with incidents affecting diagnosis (β = 0.43; delayed and wrong), and treatment (0.12; delayed, wrong treatment, or dose), which were in turn associated with incidents with patient-provider communication, coordination between providers, appointments, and laboratory tests. Pain was associated with laboratory tests (0.21; caused when collecting blood or tissue samples) and with problems booking an appointment when needed (0.13; delaying treatment for pain). Harm to mental health was associated with incidents related to the following: diagnosis (0.28), patient-provider communication (0.18), appointments (0.17), coordination between different providers (0.14), and laboratory tests (0.12). Harm increasing limitations in social activities was associated with incidents related to diagnosis (0.42) and diagnostic and monitoring procedures (0.20). CONCLUSIONS: Our findings suggest the need for patient-centered strategies to reduce harm in primary care focusing on the improvement of the quality of diagnosis and patient-provider communication.

  @article{Ricci_Cabello_2021,
  abstract = {OBJECTIVE: The aim of the study was to identify the main factors leading to harm in primary care based on the experiences reported by patients. METHODS: We conducted a mixed-methods, cross-sectional study in 45 primary care centers in England. A random sample of 6736 patients was invited to complete the Patient-Reported Experiences and Outcomes of Safety in Primary Care questionnaire. We fitted structural equation modeling on the quantitative data (n = 1244 respondents) to identify contributory factors and primary incidents leading to harm. We conducted content analyses of responses to seven open-ended questions (n = 386) to obtain deeper insight into patient perceptions of the causes of harm experienced. Results from quantitative and qualitative analyses were triangulated. RESULTS: Patients reported harm related to physical health (13%), pain (11%), and mental health (19%) and harm that increased limitations in social activities (14%). Physical harm was associated with incidents affecting diagnosis (β = 0.43; delayed and wrong), and treatment (0.12; delayed, wrong treatment, or dose), which were in turn associated with incidents with patient-provider communication, coordination between providers, appointments, and laboratory tests. Pain was associated with laboratory tests (0.21; caused when collecting blood or tissue samples) and with problems booking an appointment when needed (0.13; delaying treatment for pain). Harm to mental health was associated with incidents related to the following: diagnosis (0.28), patient-provider communication (0.18), appointments (0.17), coordination between different providers (0.14), and laboratory tests (0.12). Harm increasing limitations in social activities was associated with incidents related to diagnosis (0.42) and diagnostic and monitoring procedures (0.20). CONCLUSIONS: Our findings suggest the need for patient-centered strategies to reduce harm in primary care focusing on the improvement of the quality of diagnosis and patient-provider communication.},
  author = {Ricci-Cabello, Ignacio and Gangannagaripalli, Jaheeda and Mounce, Luke T. A. and Valderas, Jose Mar'ia},
  journal = {Journal of Patient Safety},
  keywords = {grapp-caib},
  month = {jan},
  number = 1,
  pages = {e20--e27},
  publisher = {Ovid Technologies (Wolters Kluwer Health)},
  title = {Identifying Factors Leading to Harm in English General Practices: A Mixed-Methods Study Based on Patient Experiences Integrating Structural Equation Modeling and Qualitative Content Analysis},
  volume = 17,
  year = 2021
  }
  

  %0 Journal Article
  %1 Ricci_Cabello_2021
  %A Ricci-Cabello, Ignacio
  %A Gangannagaripalli, Jaheeda
  %A Mounce, Luke T. A.
  %A Valderas, Jose Mar'ia
  %D 2021
  %I Ovid Technologies (Wolters Kluwer Health)
  %J Journal of Patient Safety
  %N 1
  %P e20--e27
  %R 10.1097/pts.0000000000000669
  %T Identifying Factors Leading to Harm in English General Practices: A Mixed-Methods Study Based on Patient Experiences Integrating Structural Equation Modeling and Qualitative Content Analysis
  %U https://doi.org/10.1097%2Fpts.0000000000000669
  %V 17
  %X OBJECTIVE: The aim of the study was to identify the main factors leading to harm in primary care based on the experiences reported by patients. METHODS: We conducted a mixed-methods, cross-sectional study in 45 primary care centers in England. A random sample of 6736 patients was invited to complete the Patient-Reported Experiences and Outcomes of Safety in Primary Care questionnaire. We fitted structural equation modeling on the quantitative data (n = 1244 respondents) to identify contributory factors and primary incidents leading to harm. We conducted content analyses of responses to seven open-ended questions (n = 386) to obtain deeper insight into patient perceptions of the causes of harm experienced. Results from quantitative and qualitative analyses were triangulated. RESULTS: Patients reported harm related to physical health (13%), pain (11%), and mental health (19%) and harm that increased limitations in social activities (14%). Physical harm was associated with incidents affecting diagnosis (β = 0.43; delayed and wrong), and treatment (0.12; delayed, wrong treatment, or dose), which were in turn associated with incidents with patient-provider communication, coordination between providers, appointments, and laboratory tests. Pain was associated with laboratory tests (0.21; caused when collecting blood or tissue samples) and with problems booking an appointment when needed (0.13; delaying treatment for pain). Harm to mental health was associated with incidents related to the following: diagnosis (0.28), patient-provider communication (0.18), appointments (0.17), coordination between different providers (0.14), and laboratory tests (0.12). Harm increasing limitations in social activities was associated with incidents related to diagnosis (0.42) and diagnostic and monitoring procedures (0.20). CONCLUSIONS: Our findings suggest the need for patient-centered strategies to reduce harm in primary care focusing on the improvement of the quality of diagnosis and patient-provider communication.
  

• 
  1.

  Rodr’iguez-Barragán M, Fernández-San-Mart’in MI, Claver’ia-Fontán A, Aldecoa-Landesa S, Casajuana-Closas M, Llobera J, Oliván-Blázquez B, Peguero-Rodr’iguez E. Validation and Psychometric Properties of the Spanish Version of the Hopkins Symptom Checklist-25 Scale for Depression Detection in Primary Care. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2021 Jul.;18(15):7843. https://doi.org/10.3390%2Fijerph18157843

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Depression constitutes a major public health problem due to its high prevalence and difficulty in diagnosis. The Hopkins Symptom Checklist-25 (HSCL-25) scale has been identified as valid, reproducible, effective, and easy to use in primary care (PC). The purpose of the study was to assess the psychometric properties of the HSCL-25 and validate its Spanish version. A multicenter cross-sectional study was carried out at six PC centers in Spain. Validity and reliability were assessed against the structured Composite International Diagnostic Interview (CIDI). Out of the 790 patients, 769 completed the HSCL-25; 738 answered all the items. Global Cronbach's alpha was 0.92 (0.88 as calculated for the depression dimension and 0.83 for the anxiety one). Confirmatory factor analysis (CFA) showed one global factor and two correlated factors with a correlation of 0.84. Area under the curve (AUC) was 0.89 (CI 95%, 0.86-0.93%). For a 1.75 cutoff point, sensibility was 88.1% (CI 95%, 77.1-95.1%) and specificity was 76.7% (CI 95%, 73.3-79.8%). The Spanish version of the HSCL-25 has a high response percentage, validity, and reliability and is well-accepted by PC patients.

  @article{Rodr_guez_Barrag_n_2021,
  abstract = {Depression constitutes a major public health problem due to its high prevalence and difficulty in diagnosis. The Hopkins Symptom Checklist-25 (HSCL-25) scale has been identified as valid, reproducible, effective, and easy to use in primary care (PC). The purpose of the study was to assess the psychometric properties of the HSCL-25 and validate its Spanish version. A multicenter cross-sectional study was carried out at six PC centers in Spain. Validity and reliability were assessed against the structured Composite International Diagnostic Interview (CIDI). Out of the 790 patients, 769 completed the HSCL-25; 738 answered all the items. Global Cronbach's alpha was 0.92 (0.88 as calculated for the depression dimension and 0.83 for the anxiety one). Confirmatory factor analysis (CFA) showed one global factor and two correlated factors with a correlation of 0.84. Area under the curve (AUC) was 0.89 (CI 95%, 0.86-0.93%). For a 1.75 cutoff point, sensibility was 88.1% (CI 95%, 77.1-95.1%) and specificity was 76.7% (CI 95%, 73.3-79.8%). The Spanish version of the HSCL-25 has a high response percentage, validity, and reliability and is well-accepted by PC patients.},
  author = {Rodr'iguez-Barragán, Mar'ia and Fernández-San-Mart'in, Mar'ia Isabel and Claver'ia-Fontán, Ana and Aldecoa-Landesa, Susana and Casajuana-Closas, Marc and Llobera, Joan and Oliván-Blázquez, Bárbara and Peguero-Rodr'iguez, Eva},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {jul},
  number = 15,
  pages = 7843,
  publisher = {MDPI AG},
  title = {Validation and Psychometric Properties of the Spanish Version of the Hopkins Symptom Checklist-25 Scale for Depression Detection in Primary Care},
  volume = 18,
  year = 2021
  }
  

  %0 Journal Article
  %1 Rodr_guez_Barrag_n_2021
  %A Rodr'iguez-Barragán, Mar'ia
  %A Fernández-San-Mart'in, Mar'ia Isabel
  %A Claver'ia-Fontán, Ana
  %A Aldecoa-Landesa, Susana
  %A Casajuana-Closas, Marc
  %A Llobera, Joan
  %A Oliván-Blázquez, Bárbara
  %A Peguero-Rodr'iguez, Eva
  %D 2021
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 15
  %P 7843
  %R 10.3390/ijerph18157843
  %T Validation and Psychometric Properties of the Spanish Version of the Hopkins Symptom Checklist-25 Scale for Depression Detection in Primary Care
  %U https://doi.org/10.3390%2Fijerph18157843
  %V 18
  %X Depression constitutes a major public health problem due to its high prevalence and difficulty in diagnosis. The Hopkins Symptom Checklist-25 (HSCL-25) scale has been identified as valid, reproducible, effective, and easy to use in primary care (PC). The purpose of the study was to assess the psychometric properties of the HSCL-25 and validate its Spanish version. A multicenter cross-sectional study was carried out at six PC centers in Spain. Validity and reliability were assessed against the structured Composite International Diagnostic Interview (CIDI). Out of the 790 patients, 769 completed the HSCL-25; 738 answered all the items. Global Cronbach's alpha was 0.92 (0.88 as calculated for the depression dimension and 0.83 for the anxiety one). Confirmatory factor analysis (CFA) showed one global factor and two correlated factors with a correlation of 0.84. Area under the curve (AUC) was 0.89 (CI 95%, 0.86-0.93%). For a 1.75 cutoff point, sensibility was 88.1% (CI 95%, 77.1-95.1%) and specificity was 76.7% (CI 95%, 73.3-79.8%). The Spanish version of the HSCL-25 has a high response percentage, validity, and reliability and is well-accepted by PC patients.
  

• 
  1.

  Serrano-Ripoll MJ, Ricci-Cabello I, Jiménez R, Zamanillo-Campos R, Yañez-Juan AM, Bennasar-Veny M, Sitges C, Gervilla E, Leiva A, García-Campayo J, García-Buades ME, García-Toro M, Pastor-Moreno G, Ruiz-Perez I, Alonso-Coello P, Llobera J, Fiol deRoque MA. Effect of a mobile-based intervention on mental health in frontline healthcare workers against COVID-19: Protocol for a randomized controlled trial. J Adv Nurs [Internet]. 2021;77(6):2898-907. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250879/pdf/JAN-77-2898.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  AIM: To evaluate the impact of a psychoeducational, mobile health intervention based on cognitive behavioural therapy and mindfulness-based approaches on the mental health of healthcare workers at the frontline against COVID-19 in Spain. DESIGN: We will carry out a two-week, individually randomized, parallel group, controlled trial. Participants will be individually randomized to receive the PsyCovidApp intervention or control App intervention. METHODS: The PsyCovidApp intervention will include five modules: emotional skills, lifestyle behaviour, work stress and burnout, social support, and practical tools. Healthcare workers having attended patients with COVID-19 will be randomized to receive the PsyCovidApp intervention (intervention group) or a control App intervention (control group). A total of 440 healthcare workers will be necessary to assure statistical power. Measures will be collected telephonically by a team of psychologists at baseline and immediately after the 2 weeks intervention period. Measures will include stress, depression and anxiety (DASS-21 questionnaire-primary endpoint), insomnia (ISI), burnout (MBI-HSS), post-traumatic stress disorder (DTS), and self-efficacy (GSE). The study was funded in May 2020, and was ethically approved in June 2020. Trial participants, outcome assessors and data analysts will be blinded to group allocation. DISCUSSION: Despite the increasing use of mobile health interventions to deliver mental health care, this area of research is still on its infancy. This study will help increase the scientific evidence about the effectiveness of this type of intervention on this specific population and context. IMPACT: Despite the lack of solid evidence about their effectiveness, mobile-based health interventions are already being widely implemented because of their low cost and high scalability. The findings from this study will help health services and organizations to make informed decisions in relation to the development and implementation of this type of interventions, allowing them pondering not only their attractive implementability features, but also empirical data about its benefits. CLINICAL TRIAL REGISTRATION: NCT04393818 (ClinicalTrials.gov identifier). APPROVED FUNDING: May 2020.

  @article{RN28,
  abstract = {AIM: To evaluate the impact of a psychoeducational, mobile health intervention based on cognitive behavioural therapy and mindfulness-based approaches on the mental health of healthcare workers at the frontline against COVID-19 in Spain. DESIGN: We will carry out a two-week, individually randomized, parallel group, controlled trial. Participants will be individually randomized to receive the PsyCovidApp intervention or control App intervention. METHODS: The PsyCovidApp intervention will include five modules: emotional skills, lifestyle behaviour, work stress and burnout, social support, and practical tools. Healthcare workers having attended patients with COVID-19 will be randomized to receive the PsyCovidApp intervention (intervention group) or a control App intervention (control group). A total of 440 healthcare workers will be necessary to assure statistical power. Measures will be collected telephonically by a team of psychologists at baseline and immediately after the 2 weeks intervention period. Measures will include stress, depression and anxiety (DASS-21 questionnaire-primary endpoint), insomnia (ISI), burnout (MBI-HSS), post-traumatic stress disorder (DTS), and self-efficacy (GSE). The study was funded in May 2020, and was ethically approved in June 2020. Trial participants, outcome assessors and data analysts will be blinded to group allocation. DISCUSSION: Despite the increasing use of mobile health interventions to deliver mental health care, this area of research is still on its infancy. This study will help increase the scientific evidence about the effectiveness of this type of intervention on this specific population and context. IMPACT: Despite the lack of solid evidence about their effectiveness, mobile-based health interventions are already being widely implemented because of their low cost and high scalability. The findings from this study will help health services and organizations to make informed decisions in relation to the development and implementation of this type of interventions, allowing them pondering not only their attractive implementability features, but also empirical data about its benefits. CLINICAL TRIAL REGISTRATION: NCT04393818 (ClinicalTrials.gov identifier). APPROVED FUNDING: May 2020.},
  author = {Serrano-Ripoll, M. J. and Ricci-Cabello, I. and Jiménez, R. and Zamanillo-Campos, R. and Yañez-Juan, A. M. and Bennasar-Veny, M. and Sitges, C. and Gervilla, E. and Leiva, A. and García-Campayo, J. and García-Buades, M. E. and García-Toro, M. and Pastor-Moreno, G. and Ruiz-Perez, I. and Alonso-Coello, P. and Llobera, J. and Fiol deRoque, M. A.},
  journal = {J Adv Nurs},
  keywords = {grapp-caib},
  number = 6,
  pages = {2898-2907},
  title = {Effect of a mobile-based intervention on mental health in frontline healthcare workers against COVID-19: Protocol for a randomized controlled trial},
  type = {Journal Article},
  volume = 77,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN28
  %A Serrano-Ripoll, M. J.
  %A Ricci-Cabello, I.
  %A Jiménez, R.
  %A Zamanillo-Campos, R.
  %A Yañez-Juan, A. M.
  %A Bennasar-Veny, M.
  %A Sitges, C.
  %A Gervilla, E.
  %A Leiva, A.
  %A García-Campayo, J.
  %A García-Buades, M. E.
  %A García-Toro, M.
  %A Pastor-Moreno, G.
  %A Ruiz-Perez, I.
  %A Alonso-Coello, P.
  %A Llobera, J.
  %A Fiol deRoque, M. A.
  %D 2021
  %J J Adv Nurs
  %N 6
  %P 2898-2907
  %R 10.1111/jan.14813
  %T Effect of a mobile-based intervention on mental health in frontline healthcare workers against COVID-19: Protocol for a randomized controlled trial
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250879/pdf/JAN-77-2898.pdf
  %V 77
  %X AIM: To evaluate the impact of a psychoeducational, mobile health intervention based on cognitive behavioural therapy and mindfulness-based approaches on the mental health of healthcare workers at the frontline against COVID-19 in Spain. DESIGN: We will carry out a two-week, individually randomized, parallel group, controlled trial. Participants will be individually randomized to receive the PsyCovidApp intervention or control App intervention. METHODS: The PsyCovidApp intervention will include five modules: emotional skills, lifestyle behaviour, work stress and burnout, social support, and practical tools. Healthcare workers having attended patients with COVID-19 will be randomized to receive the PsyCovidApp intervention (intervention group) or a control App intervention (control group). A total of 440 healthcare workers will be necessary to assure statistical power. Measures will be collected telephonically by a team of psychologists at baseline and immediately after the 2 weeks intervention period. Measures will include stress, depression and anxiety (DASS-21 questionnaire-primary endpoint), insomnia (ISI), burnout (MBI-HSS), post-traumatic stress disorder (DTS), and self-efficacy (GSE). The study was funded in May 2020, and was ethically approved in June 2020. Trial participants, outcome assessors and data analysts will be blinded to group allocation. DISCUSSION: Despite the increasing use of mobile health interventions to deliver mental health care, this area of research is still on its infancy. This study will help increase the scientific evidence about the effectiveness of this type of intervention on this specific population and context. IMPACT: Despite the lack of solid evidence about their effectiveness, mobile-based health interventions are already being widely implemented because of their low cost and high scalability. The findings from this study will help health services and organizations to make informed decisions in relation to the development and implementation of this type of interventions, allowing them pondering not only their attractive implementability features, but also empirical data about its benefits. CLINICAL TRIAL REGISTRATION: NCT04393818 (ClinicalTrials.gov identifier). APPROVED FUNDING: May 2020.
  

• 
  1.

  Gibbons C, Porter I, Gonçalves-Bradley DC, Stoilov S, Ricci-Cabello I, Tsangaris E, Gangannagaripalli J, Davey A, Gibbons EJ, Kotzeva A, Evans J, van der Wees PJ, Kontopantelis E, Greenhalgh J, Bower P, Alonso J, Valderas JM. Routine provision of feedback from patient-reported outcome measurements to healthcare providers and patients in clinical practice. Cochrane Database Syst Rev. 2021;10(10):Cd011589.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Patient-reported outcomes measures (PROMs) assess a patient's subjective appraisal of health outcomes from their own perspective. Despite hypothesised benefits that feedback  on PROMs can support decision-making in clinical practice and improve outcomes, there is uncertainty surrounding the effectiveness of PROMs feedback. OBJECTIVES: To assess the effects of PROMs feedback to patients, or healthcare workers, or both on patient-reported health outcomes and processes of care. SEARCH METHODS: We searched MEDLINE, Embase, CENTRAL, two other databases and two clinical trial registries on 5 October 2020. We searched grey literature and consulted experts in the field. SELECTION CRITERIA: Two review authors independently screened and selected studies for inclusion. We included randomised trials directly comparing the effects on outcomes and processes of care of PROMs feedback to healthcare professionals and patients, or both with the impact of not providing such information. DATA COLLECTION AND ANALYSIS: Two groups of two authors independently extracted data from the included studies and evaluated study quality. We followed standard methodological procedures expected by Cochrane and EPOC. We used the GRADE approach to assess the certainty of the evidence. We conducted meta-analyses of the results where possible. MAIN RESULTS: We identified 116 randomised trials which assessed the effectiveness of PROMs feedback in improving processes or outcomes of care, or both in a broad range of disciplines including psychiatry, primary care, and oncology. Studies were conducted across diverse ambulatory primary and secondary care settings in North America, Europe and Australasia. A total of 49,785 patients were included across all the studies. The certainty of the evidence varied between very low and moderate. Many of the studies included in the review were at risk of performance and detection bias. The evidence suggests moderate certainty that PROMs feedback probably improves quality of life (standardised mean difference (SMD) 0.15, 95% confidence interval (CI) 0.05 to 0.26; 11 studies; 2687 participants), and leads to an increase in patient-physician communication (SMD 0.36, 95% CI 0.21 to 0.52; 5 studies; 658 participants), diagnosis and notation (risk ratio (RR) 1.73, 95% CI 1.44 to 2.08; 21 studies; 7223 participants), and disease control (RR 1.25, 95% CI 1.10 to 1.41; 14 studies; 2806 participants). The intervention probably makes little or no difference for general health perceptions (SMD 0.04, 95% CI -0.17 to 0.24; 2 studies, 552 participants; low-certainty evidence), social functioning (SMD 0.02, 95% CI -0.06 to 0.09; 15 studies; 2632 participants; moderate-certainty evidence), and pain (SMD 0.00, 95% CI -0.09 to 0.08; 9 studies; 2386 participants; moderate-certainty evidence). We are uncertain about the effect of PROMs feedback on physical functioning (14 studies; 2788 participants) and mental functioning (34 studies; 7782 participants), as well as fatigue (4 studies; 741 participants), as the certainty of the evidence was very low. We did not find studies reporting on adverse effects defined as distress following or related to PROM completion. AUTHORS' CONCLUSIONS: PROM feedback probably produces moderate improvements in communication between healthcare professionals and patients as well as in diagnosis and notation, and disease control, and small improvements to quality of life. Our confidence in the effects is limited by the risk of bias, heterogeneity and small number of trials conducted to assess outcomes of interest. It is unclear whether   many of these improvements are clinically meaningful or sustainable in the long term. There is a need for more high-quality studies in this area, particularly studies which employ cluster designs and utilise techniques to maintain allocation concealment.

  @article{RN163,
  abstract = {BACKGROUND: Patient-reported outcomes measures (PROMs) assess a patient's subjective appraisal of health outcomes from their own perspective. Despite hypothesised benefits that feedback  on PROMs can support decision-making in clinical practice and improve outcomes, there is uncertainty surrounding the effectiveness of PROMs feedback. OBJECTIVES: To assess the effects of PROMs feedback to patients, or healthcare workers, or both on patient-reported health outcomes and processes of care. SEARCH METHODS: We searched MEDLINE, Embase, CENTRAL, two other databases and two clinical trial registries on 5 October 2020. We searched grey literature and consulted experts in the field. SELECTION CRITERIA: Two review authors independently screened and selected studies for inclusion. We included randomised trials directly comparing the effects on outcomes and processes of care of PROMs feedback to healthcare professionals and patients, or both with the impact of not providing such information. DATA COLLECTION AND ANALYSIS: Two groups of two authors independently extracted data from the included studies and evaluated study quality. We followed standard methodological procedures expected by Cochrane and EPOC. We used the GRADE approach to assess the certainty of the evidence. We conducted meta-analyses of the results where possible. MAIN RESULTS: We identified 116 randomised trials which assessed the effectiveness of PROMs feedback in improving processes or outcomes of care, or both in a broad range of disciplines including psychiatry, primary care, and oncology. Studies were conducted across diverse ambulatory primary and secondary care settings in North America, Europe and Australasia. A total of 49,785 patients were included across all the studies. The certainty of the evidence varied between very low and moderate. Many of the studies included in the review were at risk of performance and detection bias. The evidence suggests moderate certainty that PROMs feedback probably improves quality of life (standardised mean difference (SMD) 0.15, 95% confidence interval (CI) 0.05 to 0.26; 11 studies; 2687 participants), and leads to an increase in patient-physician communication (SMD 0.36, 95% CI 0.21 to 0.52; 5 studies; 658 participants), diagnosis and notation (risk ratio (RR) 1.73, 95% CI 1.44 to 2.08; 21 studies; 7223 participants), and disease control (RR 1.25, 95% CI 1.10 to 1.41; 14 studies; 2806 participants). The intervention probably makes little or no difference for general health perceptions (SMD 0.04, 95% CI -0.17 to 0.24; 2 studies, 552 participants; low-certainty evidence), social functioning (SMD 0.02, 95% CI -0.06 to 0.09; 15 studies; 2632 participants; moderate-certainty evidence), and pain (SMD 0.00, 95% CI -0.09 to 0.08; 9 studies; 2386 participants; moderate-certainty evidence). We are uncertain about the effect of PROMs feedback on physical functioning (14 studies; 2788 participants) and mental functioning (34 studies; 7782 participants), as well as fatigue (4 studies; 741 participants), as the certainty of the evidence was very low. We did not find studies reporting on adverse effects defined as distress following or related to PROM completion. AUTHORS' CONCLUSIONS: PROM feedback probably produces moderate improvements in communication between healthcare professionals and patients as well as in diagnosis and notation, and disease control, and small improvements to quality of life. Our confidence in the effects is limited by the risk of bias, heterogeneity and small number of trials conducted to assess outcomes of interest. It is unclear whether   many of these improvements are clinically meaningful or sustainable in the long term. There is a need for more high-quality studies in this area, particularly studies which employ cluster designs and utilise techniques to maintain allocation concealment.},
  author = {Gibbons, C. and Porter, I. and Gonçalves-Bradley, D. C. and Stoilov, S. and Ricci-Cabello, I. and Tsangaris, E. and Gangannagaripalli, J. and Davey, A. and Gibbons, E. J. and Kotzeva, A. and Evans, J. and van der Wees, P. J. and Kontopantelis, E. and Greenhalgh, J. and Bower, P. and Alonso, J. and Valderas, J. M.},
  journal = {Cochrane Database Syst Rev},
  keywords = {grapp-caib myown},
  number = 10,
  pages = {Cd011589},
  title = {Routine provision of feedback from patient-reported outcome measurements to healthcare providers and patients in clinical practice},
  type = {Journal Article},
  volume = 10,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN163
  %A Gibbons, C.
  %A Porter, I.
  %A Gonçalves-Bradley, D. C.
  %A Stoilov, S.
  %A Ricci-Cabello, I.
  %A Tsangaris, E.
  %A Gangannagaripalli, J.
  %A Davey, A.
  %A Gibbons, E. J.
  %A Kotzeva, A.
  %A Evans, J.
  %A van der Wees, P. J.
  %A Kontopantelis, E.
  %A Greenhalgh, J.
  %A Bower, P.
  %A Alonso, J.
  %A Valderas, J. M.
  %D 2021
  %J Cochrane Database Syst Rev
  %N 10
  %P Cd011589
  %R 10.1002/14651858.CD011589.pub2
  %T Routine provision of feedback from patient-reported outcome measurements to healthcare providers and patients in clinical practice
  %V 10
  %X BACKGROUND: Patient-reported outcomes measures (PROMs) assess a patient's subjective appraisal of health outcomes from their own perspective. Despite hypothesised benefits that feedback  on PROMs can support decision-making in clinical practice and improve outcomes, there is uncertainty surrounding the effectiveness of PROMs feedback. OBJECTIVES: To assess the effects of PROMs feedback to patients, or healthcare workers, or both on patient-reported health outcomes and processes of care. SEARCH METHODS: We searched MEDLINE, Embase, CENTRAL, two other databases and two clinical trial registries on 5 October 2020. We searched grey literature and consulted experts in the field. SELECTION CRITERIA: Two review authors independently screened and selected studies for inclusion. We included randomised trials directly comparing the effects on outcomes and processes of care of PROMs feedback to healthcare professionals and patients, or both with the impact of not providing such information. DATA COLLECTION AND ANALYSIS: Two groups of two authors independently extracted data from the included studies and evaluated study quality. We followed standard methodological procedures expected by Cochrane and EPOC. We used the GRADE approach to assess the certainty of the evidence. We conducted meta-analyses of the results where possible. MAIN RESULTS: We identified 116 randomised trials which assessed the effectiveness of PROMs feedback in improving processes or outcomes of care, or both in a broad range of disciplines including psychiatry, primary care, and oncology. Studies were conducted across diverse ambulatory primary and secondary care settings in North America, Europe and Australasia. A total of 49,785 patients were included across all the studies. The certainty of the evidence varied between very low and moderate. Many of the studies included in the review were at risk of performance and detection bias. The evidence suggests moderate certainty that PROMs feedback probably improves quality of life (standardised mean difference (SMD) 0.15, 95% confidence interval (CI) 0.05 to 0.26; 11 studies; 2687 participants), and leads to an increase in patient-physician communication (SMD 0.36, 95% CI 0.21 to 0.52; 5 studies; 658 participants), diagnosis and notation (risk ratio (RR) 1.73, 95% CI 1.44 to 2.08; 21 studies; 7223 participants), and disease control (RR 1.25, 95% CI 1.10 to 1.41; 14 studies; 2806 participants). The intervention probably makes little or no difference for general health perceptions (SMD 0.04, 95% CI -0.17 to 0.24; 2 studies, 552 participants; low-certainty evidence), social functioning (SMD 0.02, 95% CI -0.06 to 0.09; 15 studies; 2632 participants; moderate-certainty evidence), and pain (SMD 0.00, 95% CI -0.09 to 0.08; 9 studies; 2386 participants; moderate-certainty evidence). We are uncertain about the effect of PROMs feedback on physical functioning (14 studies; 2788 participants) and mental functioning (34 studies; 7782 participants), as well as fatigue (4 studies; 741 participants), as the certainty of the evidence was very low. We did not find studies reporting on adverse effects defined as distress following or related to PROM completion. AUTHORS' CONCLUSIONS: PROM feedback probably produces moderate improvements in communication between healthcare professionals and patients as well as in diagnosis and notation, and disease control, and small improvements to quality of life. Our confidence in the effects is limited by the risk of bias, heterogeneity and small number of trials conducted to assess outcomes of interest. It is unclear whether   many of these improvements are clinically meaningful or sustainable in the long term. There is a need for more high-quality studies in this area, particularly studies which employ cluster designs and utilise techniques to maintain allocation concealment.
  

• 
  1.

  Hernández-Rodríguez M, Sempere-Verdú E, Vicens-Caldentey C, González-Rubio F, Miguel-García F, Palop-Larrea V, Orueta-Sánchez R, Esteban-Jiménez Ó, Sempere-Manuel M, Arroyo-Aniés MP, Fernández-San José B, de Juan-Roldán JI, Ioakeim-Skoufa I. Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2021 Apr.;18(9):4754. https://doi.org/10.3390%2Fijerph18094754

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15-44 years); antidepressants, PPIs, and selective β-blockers (45-64 years); selective β-blockers, biguanides, PPIs, and statins (65-79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions' appropriateness.

  @article{Hern_ndez_Rodr_guez_2021,
  abstract = {We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15-44 years); antidepressants, PPIs, and selective β-blockers (45-64 years); selective β-blockers, biguanides, PPIs, and statins (65-79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions' appropriateness.},
  author = {Hernández-Rodríguez, MÁ and Sempere-Verdú, E. and Vicens-Caldentey, C. and González-Rubio, F. and Miguel-García, F. and Palop-Larrea, V. and Orueta-Sánchez, R. and Esteban-Jiménez, Ó and Sempere-Manuel, M. and Arroyo-Aniés, M. P. and Fernández-San José, B. and de Juan-Roldán, J. I. and Ioakeim-Skoufa, I.},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {apr},
  number = 9,
  pages = 4754,
  publisher = {MDPI AG},
  title = {Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data},
  volume = 18,
  year = 2021
  }
  

  %0 Journal Article
  %1 Hern_ndez_Rodr_guez_2021
  %A Hernández-Rodríguez, MÁ
  %A Sempere-Verdú, E.
  %A Vicens-Caldentey, C.
  %A González-Rubio, F.
  %A Miguel-García, F.
  %A Palop-Larrea, V.
  %A Orueta-Sánchez, R.
  %A Esteban-Jiménez, Ó
  %A Sempere-Manuel, M.
  %A Arroyo-Aniés, M. P.
  %A Fernández-San José, B.
  %A de Juan-Roldán, J. I.
  %A Ioakeim-Skoufa, I.
  %D 2021
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 9
  %P 4754
  %R 10.3390/ijerph18094754
  %T Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data
  %U https://doi.org/10.3390%2Fijerph18094754
  %V 18
  %X We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15-44 years); antidepressants, PPIs, and selective β-blockers (45-64 years); selective β-blockers, biguanides, PPIs, and statins (65-79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions' appropriateness.
  

• 
  1.

  Ricci-Cabello I, Ya~nez-Juan AM, Fiol deRoque MA, Leiva A, Canaves JL, Parmentier FBR, Valderas JM. Assessing the Impact of Multi-Morbidity and Related Constructs on Patient Reported Safety in Primary Care: Generalized Structural Equation Modelling of Observational Data. Journal of Clinical Medicine [Internet]. MDPI AG; 2021 Apr.;10(8):1782. https://doi.org/10.3390%2Fjcm10081782

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  We aimed to examine the complex relationships between patient safety processes and outcomes and multimorbidity using a comprehensive set of constructs: multimorbidity, polypharmacy, discordant comorbidity (diseases not sharing either pathogenesis nor management), morbidity burden and patient complexity. We used cross-sectional data from 4782 patients in 69 primary care centres in Spain. We constructed generalized structural equation models to examine the associations between multimorbidity constructs and patient-reported patient safety (PREOS-PC questionnaire). These associations were modelled through direct and indirect (mediated by increased interactions with healthcare) pathways. For women, a consistent association between higher levels of the multimorbidity constructs and lower levels of patient safety was observed via either pathway. The findings for men replicated these observations for polypharmacy, morbidity burden and patient complexity via indirect pathways. However, direct pathways showed unexpected associations between higher levels of multimorbidity and better safety. The consistent association between multimorbidity constructs and worse patient safety among women makes it advisable to target this group for the development of interventions, with particular attention to the role of comorbidity discordance. Further research, particularly qualitative research, is needed for clarifying the complex associations among men.

  @article{Ricci_Cabello_2021,
  abstract = {We aimed to examine the complex relationships between patient safety processes and outcomes and multimorbidity using a comprehensive set of constructs: multimorbidity, polypharmacy, discordant comorbidity (diseases not sharing either pathogenesis nor management), morbidity burden and patient complexity. We used cross-sectional data from 4782 patients in 69 primary care centres in Spain. We constructed generalized structural equation models to examine the associations between multimorbidity constructs and patient-reported patient safety (PREOS-PC questionnaire). These associations were modelled through direct and indirect (mediated by increased interactions with healthcare) pathways. For women, a consistent association between higher levels of the multimorbidity constructs and lower levels of patient safety was observed via either pathway. The findings for men replicated these observations for polypharmacy, morbidity burden and patient complexity via indirect pathways. However, direct pathways showed unexpected associations between higher levels of multimorbidity and better safety. The consistent association between multimorbidity constructs and worse patient safety among women makes it advisable to target this group for the development of interventions, with particular attention to the role of comorbidity discordance. Further research, particularly qualitative research, is needed for clarifying the complex associations among men.},
  author = {Ricci-Cabello, Ignacio and Ya~nez-Juan, Aina Mar'ia and Fiol deRoque, Maria A. and Leiva, Alfonso and Canaves, Joan Llobera and Parmentier, Fabrice B. R. and Valderas, Jose M.},
  journal = {Journal of Clinical Medicine},
  keywords = {grapp-caib myown},
  month = {apr},
  number = 8,
  pages = 1782,
  publisher = {MDPI AG},
  title = {Assessing the Impact of Multi-Morbidity and Related Constructs on Patient Reported Safety in Primary Care: Generalized Structural Equation Modelling of Observational Data},
  volume = 10,
  year = 2021
  }
  

  %0 Journal Article
  %1 Ricci_Cabello_2021
  %A Ricci-Cabello, Ignacio
  %A Ya~nez-Juan, Aina Mar'ia
  %A Fiol deRoque, Maria A.
  %A Leiva, Alfonso
  %A Canaves, Joan Llobera
  %A Parmentier, Fabrice B. R.
  %A Valderas, Jose M.
  %D 2021
  %I MDPI AG
  %J Journal of Clinical Medicine
  %N 8
  %P 1782
  %R 10.3390/jcm10081782
  %T Assessing the Impact of Multi-Morbidity and Related Constructs on Patient Reported Safety in Primary Care: Generalized Structural Equation Modelling of Observational Data
  %U https://doi.org/10.3390%2Fjcm10081782
  %V 10
  %X We aimed to examine the complex relationships between patient safety processes and outcomes and multimorbidity using a comprehensive set of constructs: multimorbidity, polypharmacy, discordant comorbidity (diseases not sharing either pathogenesis nor management), morbidity burden and patient complexity. We used cross-sectional data from 4782 patients in 69 primary care centres in Spain. We constructed generalized structural equation models to examine the associations between multimorbidity constructs and patient-reported patient safety (PREOS-PC questionnaire). These associations were modelled through direct and indirect (mediated by increased interactions with healthcare) pathways. For women, a consistent association between higher levels of the multimorbidity constructs and lower levels of patient safety was observed via either pathway. The findings for men replicated these observations for polypharmacy, morbidity burden and patient complexity via indirect pathways. However, direct pathways showed unexpected associations between higher levels of multimorbidity and better safety. The consistent association between multimorbidity constructs and worse patient safety among women makes it advisable to target this group for the development of interventions, with particular attention to the role of comorbidity discordance. Further research, particularly qualitative research, is needed for clarifying the complex associations among men.
  

• 
  1.

  Zamanillo Campos R, Rovira Boixadera L, Rendo Urteaga T. [Common practices and beliefs in the preparation of complementary infant feeding in a Spanish sample: a cross-sectional study]. Nutr Hosp. 2021;38(5):919-34.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  Introduction: complementary feeding together with breast milk should cover the nutritional needs of children from 6 months onwards. Thus, inadequate dietary practices can lead to poor nutritional intake. The objective of this study was to examine infant food handling and cooking in Spanish households. Methodology: a cross-sectional study was carried out using an online survey in non-institutionalized adults living in Spain who usually prepare infant food for children under 2 years of age. Results: a total of 1,944 people (37.4 ± 6 years; 65.5 % women) answered the survey. Of these, 72 % prepared mainly mashed foods and 21 % used store-bought baby cereals frequently. Zucchini (39 %), chicken (62 %), hake (64 %) and banana (44 %) were the most commonly used foods. Boiling (63 %) and freezing (59 %) were the most widely used culinary and preservation practices. An inappropriate use of salt and some unsafe foods (large fish and chard) was identified, whereas olive oil and eggs were offered below the current nutritional recommendations. Conclusion: the population surveyed preferred to use mashed foods to feed children under 2 years of age. Even though they were aware that homemade food is nutritionally better, on certain occasions they offer store-bought baby cereal. Furthermore, some inappropriate feeding practices were detected, highlighting the need to implement nutritional education policies regarding infant food preparation.

  @article{RN184,
  abstract = {Introduction: complementary feeding together with breast milk should cover the nutritional needs of children from 6 months onwards. Thus, inadequate dietary practices can lead to poor nutritional intake. The objective of this study was to examine infant food handling and cooking in Spanish households. Methodology: a cross-sectional study was carried out using an online survey in non-institutionalized adults living in Spain who usually prepare infant food for children under 2 years of age. Results: a total of 1,944 people (37.4 ± 6 years; 65.5 % women) answered the survey. Of these, 72 % prepared mainly mashed foods and 21 % used store-bought baby cereals frequently. Zucchini (39 %), chicken (62 %), hake (64 %) and banana (44 %) were the most commonly used foods. Boiling (63 %) and freezing (59 %) were the most widely used culinary and preservation practices. An inappropriate use of salt and some unsafe foods (large fish and chard) was identified, whereas olive oil and eggs were offered below the current nutritional recommendations. Conclusion: the population surveyed preferred to use mashed foods to feed children under 2 years of age. Even though they were aware that homemade food is nutritionally better, on certain occasions they offer store-bought baby cereal. Furthermore, some inappropriate feeding practices were detected, highlighting the need to implement nutritional education policies regarding infant food preparation.},
  author = {Zamanillo Campos, R. and Rovira Boixadera, L. and Rendo Urteaga, T.},
  journal = {Nutr Hosp},
  keywords = {grapp-caib},
  number = 5,
  pages = {919-934},
  title = {[Common practices and beliefs in the preparation of complementary infant feeding in a Spanish sample: a cross-sectional study]},
  type = {Journal Article},
  volume = 38,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN184
  %A Zamanillo Campos, R.
  %A Rovira Boixadera, L.
  %A Rendo Urteaga, T.
  %D 2021
  %J Nutr Hosp
  %N 5
  %P 919-934
  %R 10.20960/nh.03527
  %T [Common practices and beliefs in the preparation of complementary infant feeding in a Spanish sample: a cross-sectional study]
  %V 38
  %X Introduction: complementary feeding together with breast milk should cover the nutritional needs of children from 6 months onwards. Thus, inadequate dietary practices can lead to poor nutritional intake. The objective of this study was to examine infant food handling and cooking in Spanish households. Methodology: a cross-sectional study was carried out using an online survey in non-institutionalized adults living in Spain who usually prepare infant food for children under 2 years of age. Results: a total of 1,944 people (37.4 ± 6 years; 65.5 % women) answered the survey. Of these, 72 % prepared mainly mashed foods and 21 % used store-bought baby cereals frequently. Zucchini (39 %), chicken (62 %), hake (64 %) and banana (44 %) were the most commonly used foods. Boiling (63 %) and freezing (59 %) were the most widely used culinary and preservation practices. An inappropriate use of salt and some unsafe foods (large fish and chard) was identified, whereas olive oil and eggs were offered below the current nutritional recommendations. Conclusion: the population surveyed preferred to use mashed foods to feed children under 2 years of age. Even though they were aware that homemade food is nutritionally better, on certain occasions they offer store-bought baby cereal. Furthermore, some inappropriate feeding practices were detected, highlighting the need to implement nutritional education policies regarding infant food preparation.
  

• 
  1.

  Ripoll J, Contreras-Martos S, Esteva M, Soler A, Serrano-Ripoll MJ. Mental Health and Psychological Wellbeing during the COVID-19 Lockdown: A Longitudinal Study in the Balearic Islands (Spain). Journal of Clinical Medicine [Internet]. MDPI AG; 2021 Jul.;10(14):3191. https://doi.org/10.3390%2Fjcm10143191

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Confining the entire population to a lockdown after the outbreak of SARS-CoV-2 was an unprecedented measure designed to protect the health of those living in Spain. The objective of the present study is to assess the evolution of mental health and psychological wellbeing during lockdown. To do this, we carried out a longitudinal study, via an online survey over the eight weeks of lockdown (weekly assessments). Sociodemographic variables were recorded, along with data related to COVID-19, psychological wellbeing (anxiety, depression, psychotropic drugs, consultations made to improve mood or anxiety), life satisfaction, and self-perceived health. A total of 681 individuals participated in the study, 76.8% were women; the mean age was 43 years old (SD = 12.7). Initially, high scores were reported for anxiety, depression, and the number of consultations to improve mood, but these decreased significantly over the study period. The reverse seems to be true for life satisfaction, perceived good health, and intake of psychotropic drugs. We also identified groups whose psychological wellbeing was more susceptible to the effects of lockdown. Women, those worried about their jobs after the pandemic, and those afraid of being infected were the most affected individuals. More generally, after the initial negative effect on psychological wellbeing, various indicators improved over the lockdown period.

  @article{Ripoll_2021,
  abstract = {Confining the entire population to a lockdown after the outbreak of SARS-CoV-2 was an unprecedented measure designed to protect the health of those living in Spain. The objective of the present study is to assess the evolution of mental health and psychological wellbeing during lockdown. To do this, we carried out a longitudinal study, via an online survey over the eight weeks of lockdown (weekly assessments). Sociodemographic variables were recorded, along with data related to COVID-19, psychological wellbeing (anxiety, depression, psychotropic drugs, consultations made to improve mood or anxiety), life satisfaction, and self-perceived health. A total of 681 individuals participated in the study, 76.8% were women; the mean age was 43 years old (SD = 12.7). Initially, high scores were reported for anxiety, depression, and the number of consultations to improve mood, but these decreased significantly over the study period. The reverse seems to be true for life satisfaction, perceived good health, and intake of psychotropic drugs. We also identified groups whose psychological wellbeing was more susceptible to the effects of lockdown. Women, those worried about their jobs after the pandemic, and those afraid of being infected were the most affected individuals. More generally, after the initial negative effect on psychological wellbeing, various indicators improved over the lockdown period.},
  author = {Ripoll, Joana and Contreras-Martos, Sara and Esteva, Magdalena and Soler, Aina and Serrano-Ripoll, Maria Jesús},
  journal = {Journal of Clinical Medicine},
  keywords = {grapp-caib},
  month = {jul},
  number = 14,
  pages = 3191,
  publisher = {MDPI AG},
  title = {Mental Health and Psychological Wellbeing during the COVID-19 Lockdown: A Longitudinal Study in the Balearic Islands (Spain)},
  volume = 10,
  year = 2021
  }
  

  %0 Journal Article
  %1 Ripoll_2021
  %A Ripoll, Joana
  %A Contreras-Martos, Sara
  %A Esteva, Magdalena
  %A Soler, Aina
  %A Serrano-Ripoll, Maria Jesús
  %D 2021
  %I MDPI AG
  %J Journal of Clinical Medicine
  %N 14
  %P 3191
  %R 10.3390/jcm10143191
  %T Mental Health and Psychological Wellbeing during the COVID-19 Lockdown: A Longitudinal Study in the Balearic Islands (Spain)
  %U https://doi.org/10.3390%2Fjcm10143191
  %V 10
  %X Confining the entire population to a lockdown after the outbreak of SARS-CoV-2 was an unprecedented measure designed to protect the health of those living in Spain. The objective of the present study is to assess the evolution of mental health and psychological wellbeing during lockdown. To do this, we carried out a longitudinal study, via an online survey over the eight weeks of lockdown (weekly assessments). Sociodemographic variables were recorded, along with data related to COVID-19, psychological wellbeing (anxiety, depression, psychotropic drugs, consultations made to improve mood or anxiety), life satisfaction, and self-perceived health. A total of 681 individuals participated in the study, 76.8% were women; the mean age was 43 years old (SD = 12.7). Initially, high scores were reported for anxiety, depression, and the number of consultations to improve mood, but these decreased significantly over the study period. The reverse seems to be true for life satisfaction, perceived good health, and intake of psychotropic drugs. We also identified groups whose psychological wellbeing was more susceptible to the effects of lockdown. Women, those worried about their jobs after the pandemic, and those afraid of being infected were the most affected individuals. More generally, after the initial negative effect on psychological wellbeing, various indicators improved over the lockdown period.
  

• 
  1.

  Ripoll J, Ramos M, Montaño J, Pons J, Ameijide A, Franch P. Cancer-specific survival by stage of bladder cancer and factors collected by Mallorca Cancer Registry associated to survival. BMC Cancer. 2021;21(1):676.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Information about survival by stage in bladder cancer is scarce, as well as about survival of non-invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage; 2) to determine cancer-specific survival by stage of bladder cancer; 3) to identify factors that explain and predict the likelihood of survival and the risk of dying from these cancers. METHODS: Incident bladder cancer cases diagnosed between 2006 and 2011 were identified through the Mallorca Cancer Registry. INCLUSION CRITERIA: cases with code C67 according to the ICD-O 3rd edition with any behaviour and any histology, except lymphomas and small cell carcinomas. Cases identified exclusively through the death certificate were excluded. We collected the following data: sex; age; date and method of diagnosis; histology according to the ICD-O 3rd edition; T, N, M and stage at the time of diagnosis; and date of follow-up or death. End point of follow-up was 31 December 2015. Multiple imputation (MI) was performed to estimate cases with unknown stage. Cases with benign or indeterminate behaviour were excluded for the survival analysis. Actuarial and Kaplan-Meier methods and Cox regression models were used for survival analysis. RESULTS: One thousand nine hundred fourteen cases were identified. 14% were women and 65.4% were 65 years or older. 3.9% had no stage (benign or undetermined behaviour) and 11.5% had unknown stage. After MI, 37.5% were in stage Ta (non-invasive papillary carcinoma), 3.2% in stage Tis (carcinoma in situ), 34.3% in stage I, 11.7% in Stage II, 4.3% in stage III, and 9.0% in stage IV. Survival was 76% at 5 years. Survival by stage: 98% at stage Ta, 90% at stage Tis, 85% at stage I, 45% at stage II, 35% at stage III, and 7% at stage IV. The Cox model showed that age, histology, and stage, but not sex, were associated with survival. CONCLUSION: Bladder cancer survival vary greatly with stage, among both non-invasive and invasive cases. The percentage of non-invasive cancers is high. Stage, age, and histology are associated to survival.

  @article{RN177,
  abstract = {BACKGROUND: Information about survival by stage in bladder cancer is scarce, as well as about survival of non-invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage; 2) to determine cancer-specific survival by stage of bladder cancer; 3) to identify factors that explain and predict the likelihood of survival and the risk of dying from these cancers. METHODS: Incident bladder cancer cases diagnosed between 2006 and 2011 were identified through the Mallorca Cancer Registry. INCLUSION CRITERIA: cases with code C67 according to the ICD-O 3rd edition with any behaviour and any histology, except lymphomas and small cell carcinomas. Cases identified exclusively through the death certificate were excluded. We collected the following data: sex; age; date and method of diagnosis; histology according to the ICD-O 3rd edition; T, N, M and stage at the time of diagnosis; and date of follow-up or death. End point of follow-up was 31 December 2015. Multiple imputation (MI) was performed to estimate cases with unknown stage. Cases with benign or indeterminate behaviour were excluded for the survival analysis. Actuarial and Kaplan-Meier methods and Cox regression models were used for survival analysis. RESULTS: One thousand nine hundred fourteen cases were identified. 14% were women and 65.4% were 65 years or older. 3.9% had no stage (benign or undetermined behaviour) and 11.5% had unknown stage. After MI, 37.5% were in stage Ta (non-invasive papillary carcinoma), 3.2% in stage Tis (carcinoma in situ), 34.3% in stage I, 11.7% in Stage II, 4.3% in stage III, and 9.0% in stage IV. Survival was 76% at 5 years. Survival by stage: 98% at stage Ta, 90% at stage Tis, 85% at stage I, 45% at stage II, 35% at stage III, and 7% at stage IV. The Cox model showed that age, histology, and stage, but not sex, were associated with survival. CONCLUSION: Bladder cancer survival vary greatly with stage, among both non-invasive and invasive cases. The percentage of non-invasive cancers is high. Stage, age, and histology are associated to survival.},
  author = {Ripoll, J. and Ramos, M. and Montaño, J. and Pons, J. and Ameijide, A. and Franch, P.},
  journal = {BMC Cancer},
  keywords = {grapp-caib},
  number = 1,
  pages = 676,
  title = {Cancer-specific survival by stage of bladder cancer and factors collected by Mallorca Cancer Registry associated to survival},
  type = {Journal Article},
  volume = 21,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN177
  %A Ripoll, J.
  %A Ramos, M.
  %A Montaño, J.
  %A Pons, J.
  %A Ameijide, A.
  %A Franch, P.
  %D 2021
  %J BMC Cancer
  %N 1
  %P 676
  %R 10.1186/s12885-021-08418-y
  %T Cancer-specific survival by stage of bladder cancer and factors collected by Mallorca Cancer Registry associated to survival
  %V 21
  %X BACKGROUND: Information about survival by stage in bladder cancer is scarce, as well as about survival of non-invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage; 2) to determine cancer-specific survival by stage of bladder cancer; 3) to identify factors that explain and predict the likelihood of survival and the risk of dying from these cancers. METHODS: Incident bladder cancer cases diagnosed between 2006 and 2011 were identified through the Mallorca Cancer Registry. INCLUSION CRITERIA: cases with code C67 according to the ICD-O 3rd edition with any behaviour and any histology, except lymphomas and small cell carcinomas. Cases identified exclusively through the death certificate were excluded. We collected the following data: sex; age; date and method of diagnosis; histology according to the ICD-O 3rd edition; T, N, M and stage at the time of diagnosis; and date of follow-up or death. End point of follow-up was 31 December 2015. Multiple imputation (MI) was performed to estimate cases with unknown stage. Cases with benign or indeterminate behaviour were excluded for the survival analysis. Actuarial and Kaplan-Meier methods and Cox regression models were used for survival analysis. RESULTS: One thousand nine hundred fourteen cases were identified. 14% were women and 65.4% were 65 years or older. 3.9% had no stage (benign or undetermined behaviour) and 11.5% had unknown stage. After MI, 37.5% were in stage Ta (non-invasive papillary carcinoma), 3.2% in stage Tis (carcinoma in situ), 34.3% in stage I, 11.7% in Stage II, 4.3% in stage III, and 9.0% in stage IV. Survival was 76% at 5 years. Survival by stage: 98% at stage Ta, 90% at stage Tis, 85% at stage I, 45% at stage II, 35% at stage III, and 7% at stage IV. The Cox model showed that age, histology, and stage, but not sex, were associated with survival. CONCLUSION: Bladder cancer survival vary greatly with stage, among both non-invasive and invasive cases. The percentage of non-invasive cancers is high. Stage, age, and histology are associated to survival.
  

• 
  1.

  Torrens Darder I, Argüelles-Vázquez R, Lorente-Montalvo P, Torrens-Darder MDM, Esteva M. Primary care is the frontline for help-seeking insomnia patients. Eur J Gen Pract. 2021;27(1):286-93.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Although insomnia is a very common disorder, few people seek medical help. OBJECTIVES: To determine the proportion of people who consult a healthcare professional about insomnia and examine reasons for help seeking. METHODS: Descriptive study of 99 patients diagnosed with insomnia following a telephone survey of 466 adults assigned to a primary healthcare unit in Majorca (Spain). Data were obtained from interviews and subsequent review of electronic medical records. RESULTS: Thirty-nine patients (39.8%) consulted at least once with one health care professional; 36(92.2%) consulted a general practitioner. Only 12.2% had an insomnia diagnosis registered in their medical record. Insomnia consultation was not associated with any sociodemographic variables analysed, anxiety, depression or comorbidities. Also, there was no association with sleep quality, duration, and sleep efficiency. Patients with clinical insomnia (OR, 2.48; 95% CI, 1.03-5.94), those who were more worried (OR, 2.93; 95% CI 1.08-7.95) or felt that others noticed the impact of insomnia on their quality of life (OR, 2.48; 95% CI, 1.02-19.08) are more likely to seek medical help. Patients taking sleep medication were 21.54 (95% CI, 7.34-63.20) times more likely to have asked for medical assistance. CONCLUSION: Insomnia is an under-reported problem for both patients and doctors. When patients decide to consult for insomnia problems, they first go to the GP, and the vast majority take medications for their sleep problem. Those who consult most are people with more severe insomnia and those who are more worried.

  @article{RN180,
  abstract = {BACKGROUND: Although insomnia is a very common disorder, few people seek medical help. OBJECTIVES: To determine the proportion of people who consult a healthcare professional about insomnia and examine reasons for help seeking. METHODS: Descriptive study of 99 patients diagnosed with insomnia following a telephone survey of 466 adults assigned to a primary healthcare unit in Majorca (Spain). Data were obtained from interviews and subsequent review of electronic medical records. RESULTS: Thirty-nine patients (39.8%) consulted at least once with one health care professional; 36(92.2%) consulted a general practitioner. Only 12.2% had an insomnia diagnosis registered in their medical record. Insomnia consultation was not associated with any sociodemographic variables analysed, anxiety, depression or comorbidities. Also, there was no association with sleep quality, duration, and sleep efficiency. Patients with clinical insomnia (OR, 2.48; 95% CI, 1.03-5.94), those who were more worried (OR, 2.93; 95% CI 1.08-7.95) or felt that others noticed the impact of insomnia on their quality of life (OR, 2.48; 95% CI, 1.02-19.08) are more likely to seek medical help. Patients taking sleep medication were 21.54 (95% CI, 7.34-63.20) times more likely to have asked for medical assistance. CONCLUSION: Insomnia is an under-reported problem for both patients and doctors. When patients decide to consult for insomnia problems, they first go to the GP, and the vast majority take medications for their sleep problem. Those who consult most are people with more severe insomnia and those who are more worried.},
  author = {Torrens Darder, I. and Argüelles-Vázquez, R. and Lorente-Montalvo, P. and Torrens-Darder, M. D. M. and Esteva, M.},
  journal = {Eur J Gen Pract},
  keywords = {grapp-caib},
  number = 1,
  pages = {286-293},
  title = {Primary care is the frontline for help-seeking insomnia patients},
  type = {Journal Article},
  volume = 27,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN180
  %A Torrens Darder, I.
  %A Argüelles-Vázquez, R.
  %A Lorente-Montalvo, P.
  %A Torrens-Darder, M. D. M.
  %A Esteva, M.
  %D 2021
  %J Eur J Gen Pract
  %N 1
  %P 286-293
  %R 10.1080/13814788.2021.1960308
  %T Primary care is the frontline for help-seeking insomnia patients
  %V 27
  %X BACKGROUND: Although insomnia is a very common disorder, few people seek medical help. OBJECTIVES: To determine the proportion of people who consult a healthcare professional about insomnia and examine reasons for help seeking. METHODS: Descriptive study of 99 patients diagnosed with insomnia following a telephone survey of 466 adults assigned to a primary healthcare unit in Majorca (Spain). Data were obtained from interviews and subsequent review of electronic medical records. RESULTS: Thirty-nine patients (39.8%) consulted at least once with one health care professional; 36(92.2%) consulted a general practitioner. Only 12.2% had an insomnia diagnosis registered in their medical record. Insomnia consultation was not associated with any sociodemographic variables analysed, anxiety, depression or comorbidities. Also, there was no association with sleep quality, duration, and sleep efficiency. Patients with clinical insomnia (OR, 2.48; 95% CI, 1.03-5.94), those who were more worried (OR, 2.93; 95% CI 1.08-7.95) or felt that others noticed the impact of insomnia on their quality of life (OR, 2.48; 95% CI, 1.02-19.08) are more likely to seek medical help. Patients taking sleep medication were 21.54 (95% CI, 7.34-63.20) times more likely to have asked for medical assistance. CONCLUSION: Insomnia is an under-reported problem for both patients and doctors. When patients decide to consult for insomnia problems, they first go to the GP, and the vast majority take medications for their sleep problem. Those who consult most are people with more severe insomnia and those who are more worried.
  

• 
  1.

  Torrens I, Esteva M, Vicens C, Pizá-Portell MR, Vidal-Thomàs MC, Vidal-Ribas C, Lorente-Montalvo P, Torres-Solera E. Assessing the feasibility and acceptability of a cluster-randomized study of cognitive behavioral therapy for chronic insomnia in a primary care setting. BMC Fam Pract. 2021;22(1):77.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Cognitive behavioral therapy for chronic insomnia (CBT-i) is the treatment of choice for this condition but is underutilized in patients who attend primary care. The purpose of the present feasibility-pilot study was to assess the feasibility and acceptability of a cluster-randomized study of CBT-i in a primary care setting. METHODS: This study, performed at two primary health care centers in Majorca, Spain, was a mixed methods feasibility-pilot study of a parallel cluster-randomized design comparing CBT-i and usual care (UC). Patients were included if they were 18 to 65 years-old; had diagnoses of chronic insomnia according to the Insomnia Severity Index (ISI ≥ 8); had insomnia for more than 3 months. Twenty-five GPs and nurses and 32 patients were randomly allocated to two groups. The main outcome of the intervention was improvement of dimensions of sleep quality, measured using the Spanish version of the Pittsburgh Sleep Quality Index, at baseline and at 3 months after the intervention. Other primary outcomes of the study were the feasibility and applicability of the intervention, collected through nominal groups. A thematic analysis was performed to classify primary care provider (PCP) proposals. Additionally, we assessed the recruitment process, compliance with the intervention sessions, and patient retention. RESULTS: We adapted the CBT-i approach of Morin to a primary care context. After intervention training, PCPs expressed the need for more extensive training in the different aspects of the therapy and the discussion of more cases. PCPs considered the intervention as adequate but wanted fewer but longer sessions as well as to discard the cognitive restructuring component. PCPs considered it crucial to prepare each session in advance and to establish a specific agenda for the CBT-i. Regular reminders given to PCPs and patients were suggested to improve study participation. Compared to the UC group, higher proportions of patients in the intervention group had short sleep latency, slept for longer than 5 h, and had fewer sleep disruptions. CONCLUSIONS: This feasibility-pilot study identified several key issues that must be addressed before performing a CBT-i intervention in future clinical trial in a primary care setting. TRIAL REGISTRATION: NCT04565223 . (Clinical trials.gov) Registered 1 September 2020-Retrospectively registered.

  @article{RN181,
  abstract = {BACKGROUND: Cognitive behavioral therapy for chronic insomnia (CBT-i) is the treatment of choice for this condition but is underutilized in patients who attend primary care. The purpose of the present feasibility-pilot study was to assess the feasibility and acceptability of a cluster-randomized study of CBT-i in a primary care setting. METHODS: This study, performed at two primary health care centers in Majorca, Spain, was a mixed methods feasibility-pilot study of a parallel cluster-randomized design comparing CBT-i and usual care (UC). Patients were included if they were 18 to 65 years-old; had diagnoses of chronic insomnia according to the Insomnia Severity Index (ISI ≥ 8); had insomnia for more than 3 months. Twenty-five GPs and nurses and 32 patients were randomly allocated to two groups. The main outcome of the intervention was improvement of dimensions of sleep quality, measured using the Spanish version of the Pittsburgh Sleep Quality Index, at baseline and at 3 months after the intervention. Other primary outcomes of the study were the feasibility and applicability of the intervention, collected through nominal groups. A thematic analysis was performed to classify primary care provider (PCP) proposals. Additionally, we assessed the recruitment process, compliance with the intervention sessions, and patient retention. RESULTS: We adapted the CBT-i approach of Morin to a primary care context. After intervention training, PCPs expressed the need for more extensive training in the different aspects of the therapy and the discussion of more cases. PCPs considered the intervention as adequate but wanted fewer but longer sessions as well as to discard the cognitive restructuring component. PCPs considered it crucial to prepare each session in advance and to establish a specific agenda for the CBT-i. Regular reminders given to PCPs and patients were suggested to improve study participation. Compared to the UC group, higher proportions of patients in the intervention group had short sleep latency, slept for longer than 5 h, and had fewer sleep disruptions. CONCLUSIONS: This feasibility-pilot study identified several key issues that must be addressed before performing a CBT-i intervention in future clinical trial in a primary care setting. TRIAL REGISTRATION: NCT04565223 . (Clinical trials.gov) Registered 1 September 2020-Retrospectively registered.},
  author = {Torrens, I. and Esteva, M. and Vicens, C. and Pizá-Portell, M. R. and Vidal-Thomàs, M. C. and Vidal-Ribas, C. and Lorente-Montalvo, P. and Torres-Solera, E.},
  journal = {BMC Fam Pract},
  keywords = {grapp-caib},
  number = 1,
  pages = 77,
  title = {Assessing the feasibility and acceptability of a cluster-randomized study of cognitive behavioral therapy for chronic insomnia in a primary care setting},
  type = {Journal Article},
  volume = 22,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN181
  %A Torrens, I.
  %A Esteva, M.
  %A Vicens, C.
  %A Pizá-Portell, M. R.
  %A Vidal-Thomàs, M. C.
  %A Vidal-Ribas, C.
  %A Lorente-Montalvo, P.
  %A Torres-Solera, E.
  %D 2021
  %J BMC Fam Pract
  %N 1
  %P 77
  %R 10.1186/s12875-021-01429-5
  %T Assessing the feasibility and acceptability of a cluster-randomized study of cognitive behavioral therapy for chronic insomnia in a primary care setting
  %V 22
  %X BACKGROUND: Cognitive behavioral therapy for chronic insomnia (CBT-i) is the treatment of choice for this condition but is underutilized in patients who attend primary care. The purpose of the present feasibility-pilot study was to assess the feasibility and acceptability of a cluster-randomized study of CBT-i in a primary care setting. METHODS: This study, performed at two primary health care centers in Majorca, Spain, was a mixed methods feasibility-pilot study of a parallel cluster-randomized design comparing CBT-i and usual care (UC). Patients were included if they were 18 to 65 years-old; had diagnoses of chronic insomnia according to the Insomnia Severity Index (ISI ≥ 8); had insomnia for more than 3 months. Twenty-five GPs and nurses and 32 patients were randomly allocated to two groups. The main outcome of the intervention was improvement of dimensions of sleep quality, measured using the Spanish version of the Pittsburgh Sleep Quality Index, at baseline and at 3 months after the intervention. Other primary outcomes of the study were the feasibility and applicability of the intervention, collected through nominal groups. A thematic analysis was performed to classify primary care provider (PCP) proposals. Additionally, we assessed the recruitment process, compliance with the intervention sessions, and patient retention. RESULTS: We adapted the CBT-i approach of Morin to a primary care context. After intervention training, PCPs expressed the need for more extensive training in the different aspects of the therapy and the discussion of more cases. PCPs considered the intervention as adequate but wanted fewer but longer sessions as well as to discard the cognitive restructuring component. PCPs considered it crucial to prepare each session in advance and to establish a specific agenda for the CBT-i. Regular reminders given to PCPs and patients were suggested to improve study participation. Compared to the UC group, higher proportions of patients in the intervention group had short sleep latency, slept for longer than 5 h, and had fewer sleep disruptions. CONCLUSIONS: This feasibility-pilot study identified several key issues that must be addressed before performing a CBT-i intervention in future clinical trial in a primary care setting. TRIAL REGISTRATION: NCT04565223 . (Clinical trials.gov) Registered 1 September 2020-Retrospectively registered.
  

• 
  1.

  Castro A, Garc’ia-Palacios A, López-Del-Hoyo Y, Mayoral F, Pérez-Ara M Ángeles, Ba~nos RM, Garc’ia-Campayo J, Hurtado MM, Botella C, Barceló-Soler A, Villena A, Roca M, Gili M. Predictors of Adherence in Three Low-Intensity Intervention Programs Applied by ICTs for Depression in Primary Care. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2021 Feb.;18(4):1774. https://doi.org/10.3390%2Fijerph18041774

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Depression is one of the most common disorders in psychiatric and primary care settings, and is associated with disability, loss in quality of life, and economic costs. Internet-based psychological interventions have been shown to be effective in depression treatment but present problems with a low degree of adherence. The main aim of this study is to analyze the adherence predictors in three low-intensity interventions programs applied by Information and Communication Technologies (ICTs) for depression. A multi-center, randomized, controlled clinical trial was conducted with 164 participants with depression, who were allocated to: Healthy Lifestyle Program, Positive Affect Promotion Program or Mindfulness Program. Sociodemographic characteristics, Patient Health Questionnaire-9, Visual Analog Scale, Short Form Health Survey, Positive and Negative Affect Schedule, Five Facets Mindfulness Questionnaire, Pemberton Happiness Index and Treatment Expectancy Questionnaire were used to study adherence. Results showed that positive affect resulted in a predictor variable for Healthy Lifestyle Program and Positive Affect Promotion Program. Perceived health was also a negative adherence predictor for the Positive Affect Promotion Program. Our findings demonstrate that there are differences in clinical variables between treatment completers and non-completers and we provide adherence predictors in two intervention groups. Although new additional predictors have been examined, further research is essential in order to improve tailored interventions and increase adherence treatment.

  @article{Castro_2021,
  abstract = {Depression is one of the most common disorders in psychiatric and primary care settings, and is associated with disability, loss in quality of life, and economic costs. Internet-based psychological interventions have been shown to be effective in depression treatment but present problems with a low degree of adherence. The main aim of this study is to analyze the adherence predictors in three low-intensity interventions programs applied by Information and Communication Technologies (ICTs) for depression. A multi-center, randomized, controlled clinical trial was conducted with 164 participants with depression, who were allocated to: Healthy Lifestyle Program, Positive Affect Promotion Program or Mindfulness Program. Sociodemographic characteristics, Patient Health Questionnaire-9, Visual Analog Scale, Short Form Health Survey, Positive and Negative Affect Schedule, Five Facets Mindfulness Questionnaire, Pemberton Happiness Index and Treatment Expectancy Questionnaire were used to study adherence. Results showed that positive affect resulted in a predictor variable for Healthy Lifestyle Program and Positive Affect Promotion Program. Perceived health was also a negative adherence predictor for the Positive Affect Promotion Program. Our findings demonstrate that there are differences in clinical variables between treatment completers and non-completers and we provide adherence predictors in two intervention groups. Although new additional predictors have been examined, further research is essential in order to improve tailored interventions and increase adherence treatment.},
  author = {Castro, Adoración and Garc'ia-Palacios, Azucena and López-Del-Hoyo, Yolanda and Mayoral, Ferm'in and Pérez-Ara, Mar'ia Ángeles and Ba~nos, Rosa Mtextordfeminine and Garc'ia-Campayo, Javier and Hurtado, Mar'ia M. and Botella, Cristina and Barceló-Soler, Alberto and Villena, Amelia and Roca, Miquel and Gili, Margalida},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {feb},
  number = 4,
  pages = 1774,
  publisher = {MDPI AG},
  title = {Predictors of Adherence in Three Low-Intensity Intervention Programs Applied by ICTs for Depression in Primary Care},
  volume = 18,
  year = 2021
  }
  

  %0 Journal Article
  %1 Castro_2021
  %A Castro, Adoración
  %A Garc'ia-Palacios, Azucena
  %A López-Del-Hoyo, Yolanda
  %A Mayoral, Ferm'in
  %A Pérez-Ara, Mar'ia Ángeles
  %A Ba~nos, Rosa Mtextordfeminine
  %A Garc'ia-Campayo, Javier
  %A Hurtado, Mar'ia M.
  %A Botella, Cristina
  %A Barceló-Soler, Alberto
  %A Villena, Amelia
  %A Roca, Miquel
  %A Gili, Margalida
  %D 2021
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 4
  %P 1774
  %R 10.3390/ijerph18041774
  %T Predictors of Adherence in Three Low-Intensity Intervention Programs Applied by ICTs for Depression in Primary Care
  %U https://doi.org/10.3390%2Fijerph18041774
  %V 18
  %X Depression is one of the most common disorders in psychiatric and primary care settings, and is associated with disability, loss in quality of life, and economic costs. Internet-based psychological interventions have been shown to be effective in depression treatment but present problems with a low degree of adherence. The main aim of this study is to analyze the adherence predictors in three low-intensity interventions programs applied by Information and Communication Technologies (ICTs) for depression. A multi-center, randomized, controlled clinical trial was conducted with 164 participants with depression, who were allocated to: Healthy Lifestyle Program, Positive Affect Promotion Program or Mindfulness Program. Sociodemographic characteristics, Patient Health Questionnaire-9, Visual Analog Scale, Short Form Health Survey, Positive and Negative Affect Schedule, Five Facets Mindfulness Questionnaire, Pemberton Happiness Index and Treatment Expectancy Questionnaire were used to study adherence. Results showed that positive affect resulted in a predictor variable for Healthy Lifestyle Program and Positive Affect Promotion Program. Perceived health was also a negative adherence predictor for the Positive Affect Promotion Program. Our findings demonstrate that there are differences in clinical variables between treatment completers and non-completers and we provide adherence predictors in two intervention groups. Although new additional predictors have been examined, further research is essential in order to improve tailored interventions and increase adherence treatment.
  

• 
  1.

  Zamanillo Campos R, Colomar Ferrer MT, Ruiz López RM, Sanchís Cortés MP, Urgelés Planella JR. Specific Quality of Life Assessment by the NutriQoL® Questionnaire Among Patients Receiving Home Enteral Nutrition. JPEN J Parenter Enteral Nutr. 2021;45(3):490-8.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Home enteral nutrition (HEN), including tube feeding and oral supplementation, can improve or worsen quality of life (QoL). The specific assessment of factors affecting QoL may identify the inherent problems associated with HEN. The aim of this study was to evaluate whether the validated NutriQoL® questionnaire is useful for assessing the QoL and the factors influencing it in patients receiving HEN. METHODS: A total of 78 patients receiving HEN completed both the NutriQoL and the SF-12 questionnaires during their routine visits to nutrition service at the hospital. RESULTS: Ninety percent of patients receiving HEN had cancer, 58% received oral supplements, and 42% received tube feeding. At recruitment, the mean score ± SD of the NutriQoL was 66 ± 14, whereas that of the SF-12 was 40 ± 9. A positive correlation between NutriQoL and SF-12 scores (ρ = 0.5; P < .001) was found. Multivariate analysis showed that HEN type (oral vs tube) (odds ratio [OR], 5.6; 95% CI 2.0-15.3; P = .001) and the absence of secondary effects (OR, 3.0; 95% CI, 1.2-7.9; P = .024) were both variables explaining NutriQoL results adjusted by sex and age. The SF-12 results did not show associations with nutrition factors. On visit 2, we observed significant improvements in NutriQoL results. CONCLUSION: The NutriQoL questionnaire identifies specific problems that affect the QoL of patients receiving HEN, whereas SF-12 does not. The route of entry and the occurrence of complications influence specific QoL. NutriQoL is a useful tool to identify the factors that worsen the QoL in patients receiving HEN.

  @article{RN183,
  abstract = {BACKGROUND: Home enteral nutrition (HEN), including tube feeding and oral supplementation, can improve or worsen quality of life (QoL). The specific assessment of factors affecting QoL may identify the inherent problems associated with HEN. The aim of this study was to evaluate whether the validated NutriQoL® questionnaire is useful for assessing the QoL and the factors influencing it in patients receiving HEN. METHODS: A total of 78 patients receiving HEN completed both the NutriQoL and the SF-12 questionnaires during their routine visits to nutrition service at the hospital. RESULTS: Ninety percent of patients receiving HEN had cancer, 58% received oral supplements, and 42% received tube feeding. At recruitment, the mean score ± SD of the NutriQoL was 66 ± 14, whereas that of the SF-12 was 40 ± 9. A positive correlation between NutriQoL and SF-12 scores (ρ = 0.5; P < .001) was found. Multivariate analysis showed that HEN type (oral vs tube) (odds ratio [OR], 5.6; 95% CI 2.0-15.3; P = .001) and the absence of secondary effects (OR, 3.0; 95% CI, 1.2-7.9; P = .024) were both variables explaining NutriQoL results adjusted by sex and age. The SF-12 results did not show associations with nutrition factors. On visit 2, we observed significant improvements in NutriQoL results. CONCLUSION: The NutriQoL questionnaire identifies specific problems that affect the QoL of patients receiving HEN, whereas SF-12 does not. The route of entry and the occurrence of complications influence specific QoL. NutriQoL is a useful tool to identify the factors that worsen the QoL in patients receiving HEN.},
  author = {Zamanillo Campos, R. and Colomar Ferrer, M. T. and Ruiz López, R. M. and Sanchís Cortés, M. P. and Urgelés Planella, J. R.},
  journal = {JPEN J Parenter Enteral Nutr},
  keywords = {grapp-caib},
  number = 3,
  pages = {490-498},
  title = {Specific Quality of Life Assessment by the NutriQoL® Questionnaire Among Patients Receiving Home Enteral Nutrition},
  type = {Journal Article},
  volume = 45,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN183
  %A Zamanillo Campos, R.
  %A Colomar Ferrer, M. T.
  %A Ruiz López, R. M.
  %A Sanchís Cortés, M. P.
  %A Urgelés Planella, J. R.
  %D 2021
  %J JPEN J Parenter Enteral Nutr
  %N 3
  %P 490-498
  %R 10.1002/jpen.1852
  %T Specific Quality of Life Assessment by the NutriQoL® Questionnaire Among Patients Receiving Home Enteral Nutrition
  %V 45
  %X BACKGROUND: Home enteral nutrition (HEN), including tube feeding and oral supplementation, can improve or worsen quality of life (QoL). The specific assessment of factors affecting QoL may identify the inherent problems associated with HEN. The aim of this study was to evaluate whether the validated NutriQoL® questionnaire is useful for assessing the QoL and the factors influencing it in patients receiving HEN. METHODS: A total of 78 patients receiving HEN completed both the NutriQoL and the SF-12 questionnaires during their routine visits to nutrition service at the hospital. RESULTS: Ninety percent of patients receiving HEN had cancer, 58% received oral supplements, and 42% received tube feeding. At recruitment, the mean score ± SD of the NutriQoL was 66 ± 14, whereas that of the SF-12 was 40 ± 9. A positive correlation between NutriQoL and SF-12 scores (ρ = 0.5; P < .001) was found. Multivariate analysis showed that HEN type (oral vs tube) (odds ratio [OR], 5.6; 95% CI 2.0-15.3; P = .001) and the absence of secondary effects (OR, 3.0; 95% CI, 1.2-7.9; P = .024) were both variables explaining NutriQoL results adjusted by sex and age. The SF-12 results did not show associations with nutrition factors. On visit 2, we observed significant improvements in NutriQoL results. CONCLUSION: The NutriQoL questionnaire identifies specific problems that affect the QoL of patients receiving HEN, whereas SF-12 does not. The route of entry and the occurrence of complications influence specific QoL. NutriQoL is a useful tool to identify the factors that worsen the QoL in patients receiving HEN.
  

• 
  1.

  Fiol-DeRoque MA, Serrano-Ripoll MJ, Jiménez R, Zamanillo-Campos R, Yáñez-Juan AM, Bennasar-Veny M, Leiva A, Gervilla E, García-Buades ME, García-Toro M, Alonso-Coello P, Pastor-Moreno G, Ruiz-Pérez I, Sitges C, García-Campayo J, Llobera-Cánaves J, Ricci-Cabello I. A Mobile Phone-Based Intervention to Reduce Mental Health Problems in Health Care Workers During the COVID-19 Pandemic (PsyCovidApp): Randomized Controlled Trial. JMIR Mhealth Uhealth. 2021;9(5):e27039.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: The global health emergency generated by the COVID-19 pandemic is posing an unprecedented challenge to health care workers, who are facing heavy workloads under psychologically difficult situations. Mental mobile Health (mHealth) interventions are now being widely deployed due to their attractive implementation features, despite the lack of evidence about their efficacy in this specific population and context. OBJECTIVE: The aim of this trial is to evaluate the effectiveness of a psychoeducational, mindfulness-based mHealth intervention to reduce mental health problems in health care workers during the COVID-19 pandemic. METHODS: We conducted a blinded, parallel-group, controlled trial in Spain. Health care workers providing face-to-face health care to patients with COVID-19 were randomly assigned (1:1) to receive the PsyCovidApp intervention (an app targeting emotional skills, healthy lifestyle behavior, burnout, and social support) or a control app (general recommendations about mental health care) for 2 weeks. The participants were blinded to their group allocation. Data were collected telephonically at baseline and after 2 weeks by trained health psychologists. The primary outcome was a composite of depression, anxiety, and stress (overall score on the Depression Anxiety Stress Scale-21 [DASS-21]). Secondary outcomes were insomnia (Insomnia Severity Index), burnout (Maslach Burnout Inventory Human Services Survey), posttraumatic stress (Davidson Trauma Scale), self-efficacy (General Self-Efficacy Scale), and DASS-21 individual scale scores. Differences between groups were analyzed using general linear modeling according to an intention-to-treat protocol. Additionally, we measured the usability of the PsyCovidApp (System Usability Scale). The outcome data collectors and trial statisticians were unaware of the treatment allocation. RESULTS: Between May 14 and July 25, 2020, 482 health care workers were recruited and randomly assigned to PsyCovidApp (n=248) or the control app (n=234). At 2 weeks, complete outcome data were available for 436/482 participants (90.5%). No significant differences were observed between the groups at 2 weeks in the primary outcome (standardized mean difference -0.04; 95% CI -0.11 to 0.04; P=.15) or in the other outcomes. In our prespecified subgroup analyses, we observed significant improvements among health care workers consuming psychotropic medications (n=79) in the primary outcome (-0.29; 95% CI -0.48 to -0.09; P=.004), and in posttraumatic stress, insomnia, anxiety, and stress. Similarly, among health care workers receiving psychotherapy (n=43), we observed improvements in the primary outcome (-0.25; 95% CI -0.49 to -0.02; P=.02), and in insomnia, anxiety, and stress. The mean usability score of PsyCovidApp was high (87.21/100, SD 12.65). After the trial, 208/221 participants in the intervention group (94.1%) asked to regain access to PsyCovidApp, indicating high acceptability. CONCLUSIONS: In health care workers assisting patients with COVID-19 in Spain, PsyCovidApp, compared with a control app, reduced mental health problems at 2 weeks only among health care workers receiving psychotherapy or psychotropic medications. TRIAL REGISTRATION: ClinicalTrials.gov NCT04393818; https://clinicaltrials.gov/ct2/show/NCT04393818.

  @article{RN22,
  abstract = {BACKGROUND: The global health emergency generated by the COVID-19 pandemic is posing an unprecedented challenge to health care workers, who are facing heavy workloads under psychologically difficult situations. Mental mobile Health (mHealth) interventions are now being widely deployed due to their attractive implementation features, despite the lack of evidence about their efficacy in this specific population and context. OBJECTIVE: The aim of this trial is to evaluate the effectiveness of a psychoeducational, mindfulness-based mHealth intervention to reduce mental health problems in health care workers during the COVID-19 pandemic. METHODS: We conducted a blinded, parallel-group, controlled trial in Spain. Health care workers providing face-to-face health care to patients with COVID-19 were randomly assigned (1:1) to receive the PsyCovidApp intervention (an app targeting emotional skills, healthy lifestyle behavior, burnout, and social support) or a control app (general recommendations about mental health care) for 2 weeks. The participants were blinded to their group allocation. Data were collected telephonically at baseline and after 2 weeks by trained health psychologists. The primary outcome was a composite of depression, anxiety, and stress (overall score on the Depression Anxiety Stress Scale-21 [DASS-21]). Secondary outcomes were insomnia (Insomnia Severity Index), burnout (Maslach Burnout Inventory Human Services Survey), posttraumatic stress (Davidson Trauma Scale), self-efficacy (General Self-Efficacy Scale), and DASS-21 individual scale scores. Differences between groups were analyzed using general linear modeling according to an intention-to-treat protocol. Additionally, we measured the usability of the PsyCovidApp (System Usability Scale). The outcome data collectors and trial statisticians were unaware of the treatment allocation. RESULTS: Between May 14 and July 25, 2020, 482 health care workers were recruited and randomly assigned to PsyCovidApp (n=248) or the control app (n=234). At 2 weeks, complete outcome data were available for 436/482 participants (90.5%). No significant differences were observed between the groups at 2 weeks in the primary outcome (standardized mean difference -0.04; 95% CI -0.11 to 0.04; P=.15) or in the other outcomes. In our prespecified subgroup analyses, we observed significant improvements among health care workers consuming psychotropic medications (n=79) in the primary outcome (-0.29; 95% CI -0.48 to -0.09; P=.004), and in posttraumatic stress, insomnia, anxiety, and stress. Similarly, among health care workers receiving psychotherapy (n=43), we observed improvements in the primary outcome (-0.25; 95% CI -0.49 to -0.02; P=.02), and in insomnia, anxiety, and stress. The mean usability score of PsyCovidApp was high (87.21/100, SD 12.65). After the trial, 208/221 participants in the intervention group (94.1%) asked to regain access to PsyCovidApp, indicating high acceptability. CONCLUSIONS: In health care workers assisting patients with COVID-19 in Spain, PsyCovidApp, compared with a control app, reduced mental health problems at 2 weeks only among health care workers receiving psychotherapy or psychotropic medications. TRIAL REGISTRATION: ClinicalTrials.gov NCT04393818; https://clinicaltrials.gov/ct2/show/NCT04393818.},
  author = {Fiol-DeRoque, M. A. and Serrano-Ripoll, M. J. and Jiménez, R. and Zamanillo-Campos, R. and Yáñez-Juan, A. M. and Bennasar-Veny, M. and Leiva, A. and Gervilla, E. and García-Buades, M. E. and García-Toro, M. and Alonso-Coello, P. and Pastor-Moreno, G. and Ruiz-Pérez, I. and Sitges, C. and García-Campayo, J. and Llobera-Cánaves, J. and Ricci-Cabello, I.},
  journal = {JMIR Mhealth Uhealth},
  keywords = {grapp-caib},
  number = 5,
  pages = {e27039},
  title = {A Mobile Phone-Based Intervention to Reduce Mental Health Problems in Health Care Workers During the COVID-19 Pandemic (PsyCovidApp): Randomized Controlled Trial},
  type = {Journal Article},
  volume = 9,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN22
  %A Fiol-DeRoque, M. A.
  %A Serrano-Ripoll, M. J.
  %A Jiménez, R.
  %A Zamanillo-Campos, R.
  %A Yáñez-Juan, A. M.
  %A Bennasar-Veny, M.
  %A Leiva, A.
  %A Gervilla, E.
  %A García-Buades, M. E.
  %A García-Toro, M.
  %A Alonso-Coello, P.
  %A Pastor-Moreno, G.
  %A Ruiz-Pérez, I.
  %A Sitges, C.
  %A García-Campayo, J.
  %A Llobera-Cánaves, J.
  %A Ricci-Cabello, I.
  %D 2021
  %J JMIR Mhealth Uhealth
  %N 5
  %P e27039
  %R 10.2196/27039
  %T A Mobile Phone-Based Intervention to Reduce Mental Health Problems in Health Care Workers During the COVID-19 Pandemic (PsyCovidApp): Randomized Controlled Trial
  %V 9
  %X BACKGROUND: The global health emergency generated by the COVID-19 pandemic is posing an unprecedented challenge to health care workers, who are facing heavy workloads under psychologically difficult situations. Mental mobile Health (mHealth) interventions are now being widely deployed due to their attractive implementation features, despite the lack of evidence about their efficacy in this specific population and context. OBJECTIVE: The aim of this trial is to evaluate the effectiveness of a psychoeducational, mindfulness-based mHealth intervention to reduce mental health problems in health care workers during the COVID-19 pandemic. METHODS: We conducted a blinded, parallel-group, controlled trial in Spain. Health care workers providing face-to-face health care to patients with COVID-19 were randomly assigned (1:1) to receive the PsyCovidApp intervention (an app targeting emotional skills, healthy lifestyle behavior, burnout, and social support) or a control app (general recommendations about mental health care) for 2 weeks. The participants were blinded to their group allocation. Data were collected telephonically at baseline and after 2 weeks by trained health psychologists. The primary outcome was a composite of depression, anxiety, and stress (overall score on the Depression Anxiety Stress Scale-21 [DASS-21]). Secondary outcomes were insomnia (Insomnia Severity Index), burnout (Maslach Burnout Inventory Human Services Survey), posttraumatic stress (Davidson Trauma Scale), self-efficacy (General Self-Efficacy Scale), and DASS-21 individual scale scores. Differences between groups were analyzed using general linear modeling according to an intention-to-treat protocol. Additionally, we measured the usability of the PsyCovidApp (System Usability Scale). The outcome data collectors and trial statisticians were unaware of the treatment allocation. RESULTS: Between May 14 and July 25, 2020, 482 health care workers were recruited and randomly assigned to PsyCovidApp (n=248) or the control app (n=234). At 2 weeks, complete outcome data were available for 436/482 participants (90.5%). No significant differences were observed between the groups at 2 weeks in the primary outcome (standardized mean difference -0.04; 95% CI -0.11 to 0.04; P=.15) or in the other outcomes. In our prespecified subgroup analyses, we observed significant improvements among health care workers consuming psychotropic medications (n=79) in the primary outcome (-0.29; 95% CI -0.48 to -0.09; P=.004), and in posttraumatic stress, insomnia, anxiety, and stress. Similarly, among health care workers receiving psychotherapy (n=43), we observed improvements in the primary outcome (-0.25; 95% CI -0.49 to -0.02; P=.02), and in insomnia, anxiety, and stress. The mean usability score of PsyCovidApp was high (87.21/100, SD 12.65). After the trial, 208/221 participants in the intervention group (94.1%) asked to regain access to PsyCovidApp, indicating high acceptability. CONCLUSIONS: In health care workers assisting patients with COVID-19 in Spain, PsyCovidApp, compared with a control app, reduced mental health problems at 2 weeks only among health care workers receiving psychotherapy or psychotropic medications. TRIAL REGISTRATION: ClinicalTrials.gov NCT04393818; https://clinicaltrials.gov/ct2/show/NCT04393818.
  

• 
  1.

  López-González Á A, Riutord Sbert P, Arroyo Bote S, González San Miguel H, Vidal Real C, Ramirez-Manent JI. Determination of Cardiovascular Risk in 56,262 Spanish Construction Workers. Journal of Occupational \&amp\($\mathsemicolon$\) Environmental Medicine [Internet]. Ovid Technologies (Wolters Kluwer Health); 2021 Oct.;63(12):e911-e917. https://doi.org/10.1097%2Fjom.0000000000002402

  AbstractURLBibTeXEndNoteDOIBibSonomy

  OBJECTIVE: To evaluate different cardiovascular risk scales in construction workers. METHODS: A descriptive, cross-sectional study was carried out in 56,262 Spanish construction workers. Scales of obesity and fatty liver, metabolic syndrome, atherogenic indices, and cardiovascular risk scales, among others, were assessed. RESULTS: In women, 19.6% were obese, 18.2% hypertensive, 12.6% had metabolic syndrome, 12% were at high risk of non-alcoholic fatty liver disease, and 4.3% were at moderate or high risk on the SCORE scale. In men, 20.1% were obese, 30.1% hypertensive, 17.5% had metabolic syndrome, and 27.6% had high or moderate risk on the SCORE scale. CONCLUSIONS: Knowing the cardiovascular risk of a large number of construction workers by means of a large number of scales may be of great interest to occupational health professionals, as it may enable them to establish prevention strategies.

  @article{L_pez_Gonz_lez_2021,
  abstract = {OBJECTIVE: To evaluate different cardiovascular risk scales in construction workers. METHODS: A descriptive, cross-sectional study was carried out in 56,262 Spanish construction workers. Scales of obesity and fatty liver, metabolic syndrome, atherogenic indices, and cardiovascular risk scales, among others, were assessed. RESULTS: In women, 19.6% were obese, 18.2% hypertensive, 12.6% had metabolic syndrome, 12% were at high risk of non-alcoholic fatty liver disease, and 4.3% were at moderate or high risk on the SCORE scale. In men, 20.1% were obese, 30.1% hypertensive, 17.5% had metabolic syndrome, and 27.6% had high or moderate risk on the SCORE scale. CONCLUSIONS: Knowing the cardiovascular risk of a large number of construction workers by means of a large number of scales may be of great interest to occupational health professionals, as it may enable them to establish prevention strategies.},
  author = {López-González Á, A. and Riutord Sbert, P. and Arroyo Bote, S. and González San Miguel, H. and Vidal Real, C. and Ramirez-Manent, J. I.},
  journal = {Journal of Occupational \&\($\mathsemicolon$\) Environmental Medicine},
  keywords = {grapp-caib},
  month = {oct},
  number = 12,
  pages = {e911--e917},
  publisher = {Ovid Technologies (Wolters Kluwer Health)},
  title = {Determination of Cardiovascular Risk in 56,262 Spanish Construction Workers},
  volume = 63,
  year = 2021
  }
  

  %0 Journal Article
  %1 L_pez_Gonz_lez_2021
  %A López-González Á, A.
  %A Riutord Sbert, P.
  %A Arroyo Bote, S.
  %A González San Miguel, H.
  %A Vidal Real, C.
  %A Ramirez-Manent, J. I.
  %D 2021
  %I Ovid Technologies (Wolters Kluwer Health)
  %J Journal of Occupational \&\($\mathsemicolon$\) Environmental Medicine
  %N 12
  %P e911--e917
  %R 10.1097/jom.0000000000002402
  %T Determination of Cardiovascular Risk in 56,262 Spanish Construction Workers
  %U https://doi.org/10.1097%2Fjom.0000000000002402
  %V 63
  %X OBJECTIVE: To evaluate different cardiovascular risk scales in construction workers. METHODS: A descriptive, cross-sectional study was carried out in 56,262 Spanish construction workers. Scales of obesity and fatty liver, metabolic syndrome, atherogenic indices, and cardiovascular risk scales, among others, were assessed. RESULTS: In women, 19.6% were obese, 18.2% hypertensive, 12.6% had metabolic syndrome, 12% were at high risk of non-alcoholic fatty liver disease, and 4.3% were at moderate or high risk on the SCORE scale. In men, 20.1% were obese, 30.1% hypertensive, 17.5% had metabolic syndrome, and 27.6% had high or moderate risk on the SCORE scale. CONCLUSIONS: Knowing the cardiovascular risk of a large number of construction workers by means of a large number of scales may be of great interest to occupational health professionals, as it may enable them to establish prevention strategies.
  

• 
  1.

  Contreras-Martos S, Leiva A, Sanchez Á, Motrico E, Bellón J, Aldecoa Landesa S, Magallón-Botaya R, Casajuana-Closas M, Zabaleta-Del-Olmo E, Bolíbar B, Maderuelo J, Llobera J. Implementation of the EIRA 3 Intervention by Targeting Primary Health Care Practitioners: Effectiveness in Increasing Physical Activity. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2021 Oct.;18(19):10537. https://doi.org/10.3390%2Fijerph181910537

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  The World Health Organization (WHO) estimated that physical inactivity (PI) is responsible for 20 to 30% of all non-communicable diseases. We aimed to analyze the effectiveness of a multiple health behavior change (MHBC) intervention to increase physical activity (PA) in patients 45 to 75 years old who had at least 2 of 3 unhealthy behaviors (tobacco use, reduced fruit and vegetable consumption, and insufficient PA). The MHBC intervention is based on the Transtheoretical Model and the conceptual framework of the "5 A's" and includes an individually tailored intervention, group sessions, and the use of community resources. We included 3062 participants, 1481 in the intervention group and 1581 in the control group. After 12 months, there were no differences in PA intensity measured by metabolic_equivalent_of_task_minutes/week (adjusted mean difference: 284.093, 95% CI: -298.24, 866.42) nor in the proportion of participants who increased PA levels to moderate or high (OR: 1.02, 95% CI: 0.85, 1.23; p = 0.822), and no differences in blood pressure, weight loss, or waist circumference. We found an increased proportion of patients in the intervention group who followed the WHO recommendations for PA (OR: 1.29; 95% CI: 1.04, 1.60; p = 0.02). We concluded that the intervention did not lead to a significant increase in PA.

  @article{Contreras_Martos_2021,
  abstract = {The World Health Organization (WHO) estimated that physical inactivity (PI) is responsible for 20 to 30% of all non-communicable diseases. We aimed to analyze the effectiveness of a multiple health behavior change (MHBC) intervention to increase physical activity (PA) in patients 45 to 75 years old who had at least 2 of 3 unhealthy behaviors (tobacco use, reduced fruit and vegetable consumption, and insufficient PA). The MHBC intervention is based on the Transtheoretical Model and the conceptual framework of the "5 A's" and includes an individually tailored intervention, group sessions, and the use of community resources. We included 3062 participants, 1481 in the intervention group and 1581 in the control group. After 12 months, there were no differences in PA intensity measured by metabolic_equivalent_of_task_minutes/week (adjusted mean difference: 284.093, 95% CI: -298.24, 866.42) nor in the proportion of participants who increased PA levels to moderate or high (OR: 1.02, 95% CI: 0.85, 1.23; p = 0.822), and no differences in blood pressure, weight loss, or waist circumference. We found an increased proportion of patients in the intervention group who followed the WHO recommendations for PA (OR: 1.29; 95% CI: 1.04, 1.60; p = 0.02). We concluded that the intervention did not lead to a significant increase in PA.},
  author = {Contreras-Martos, S. and Leiva, A. and Sanchez, Á and Motrico, E. and Bellón, J. and Aldecoa Landesa, S. and Magallón-Botaya, R. and Casajuana-Closas, M. and Zabaleta-Del-Olmo, E. and Bolíbar, B. and Maderuelo, JÁ and Llobera, J.},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {oct},
  number = 19,
  pages = 10537,
  publisher = {MDPI AG},
  title = {Implementation of the EIRA 3 Intervention by Targeting Primary Health Care Practitioners: Effectiveness in Increasing Physical Activity},
  volume = 18,
  year = 2021
  }
  

  %0 Journal Article
  %1 Contreras_Martos_2021
  %A Contreras-Martos, S.
  %A Leiva, A.
  %A Sanchez, Á
  %A Motrico, E.
  %A Bellón, J.
  %A Aldecoa Landesa, S.
  %A Magallón-Botaya, R.
  %A Casajuana-Closas, M.
  %A Zabaleta-Del-Olmo, E.
  %A Bolíbar, B.
  %A Maderuelo, JÁ
  %A Llobera, J.
  %D 2021
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 19
  %P 10537
  %R 10.3390/ijerph181910537
  %T Implementation of the EIRA 3 Intervention by Targeting Primary Health Care Practitioners: Effectiveness in Increasing Physical Activity
  %U https://doi.org/10.3390%2Fijerph181910537
  %V 18
  %X The World Health Organization (WHO) estimated that physical inactivity (PI) is responsible for 20 to 30% of all non-communicable diseases. We aimed to analyze the effectiveness of a multiple health behavior change (MHBC) intervention to increase physical activity (PA) in patients 45 to 75 years old who had at least 2 of 3 unhealthy behaviors (tobacco use, reduced fruit and vegetable consumption, and insufficient PA). The MHBC intervention is based on the Transtheoretical Model and the conceptual framework of the "5 A's" and includes an individually tailored intervention, group sessions, and the use of community resources. We included 3062 participants, 1481 in the intervention group and 1581 in the control group. After 12 months, there were no differences in PA intensity measured by metabolic_equivalent_of_task_minutes/week (adjusted mean difference: 284.093, 95% CI: -298.24, 866.42) nor in the proportion of participants who increased PA levels to moderate or high (OR: 1.02, 95% CI: 0.85, 1.23; p = 0.822), and no differences in blood pressure, weight loss, or waist circumference. We found an increased proportion of patients in the intervention group who followed the WHO recommendations for PA (OR: 1.29; 95% CI: 1.04, 1.60; p = 0.02). We concluded that the intervention did not lead to a significant increase in PA.
  

• 
  1.

  Aznar-Lou I, Zabaleta-Del-Olmo E, Casajuana-Closas M, Sánchez-Viñas A, Parody-Rúa E, Bolíbar B, Iracheta-Todó M, Bulilete O, López-Jiménez T, Pombo-Ramos H, Martín Miguel MV, Magallón-Botaya R, Maderuelo-Fernández J, Motrico E, Bellón J, Martí-Lluch R, Rubio-Valera M, Serrano-Blanco A. Cost-effectiveness analysis of a multiple health behaviour change intervention in people aged between 45 and 75 years: a cluster randomized controlled trial in primary care (EIRA study). Int J Behav Nutr Phys Act [Internet]. 2021;18(1):88. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254273/pdf/12966_2021_Article_1144.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Multiple health behaviour change (MHBC) interventions that promote healthy lifestyles may be an efficient approach in the prevention or treatment of chronic diseases in primary care. This study aims to evaluate the cost-utility and cost-effectiveness of the health promotion EIRA intervention in terms of MHBC and cardiovascular reduction. METHODS: An economic evaluation alongside a 12-month cluster-randomised (1:1) controlled trial conducted between 2017 and 2018 in 25 primary healthcare centres from seven Spanish regions. The study took societal and healthcare provider perspectives. Patients included were between 45 and 75 years old and had any two of these three behaviours: smoking, insufficient physical activity or low adherence to Mediterranean dietary pattern. Intervention duration was 12 months and combined three action levels (individual, group and community). MHBC, defined as a change in at least two health risk behaviours, and cardiovascular risk (expressed in % points) were the outcomes used to calculate incremental cost-effectiveness ratios (ICER). Quality-adjusted life-years (QALYs) were estimated and used to calculate incremental cost-utility ratios (ICUR). Missing data was imputed and bootstrapping with 1000 replications was used to handle uncertainty in the modelling results. RESULTS: The study included 3062 participants. Intervention costs were €295 higher than usual care costs. Five per-cent additional patients in the intervention group did a MHBC compared to usual care patients. Differences in QALYS or cardiovascular risk between-group were close to 0 (- 0.01 and 0.04 respectively). The ICER was €5598 per extra health behaviour change in one patient and €6926 per one-point reduction in cardiovascular risk from a societal perspective. The cost-utility analysis showed that the intervention increased costs and has no effect, in terms of QALYs, compared to usual care from a societal perspective. Cost-utility planes showed high uncertainty surrounding the ICUR. Sensitivity analysis showed results in line with the main analysis. CONCLUSION: The efficiency of EIRA intervention cannot be fully established and its recommendation should be conditioned by results on medium-long term effects. TRIAL REGISTRATION: Clinicaltrials.gov NCT03136211 . Registered 02 May 2017 - Retrospectively registered.

  @article{RN19,
  abstract = {BACKGROUND: Multiple health behaviour change (MHBC) interventions that promote healthy lifestyles may be an efficient approach in the prevention or treatment of chronic diseases in primary care. This study aims to evaluate the cost-utility and cost-effectiveness of the health promotion EIRA intervention in terms of MHBC and cardiovascular reduction. METHODS: An economic evaluation alongside a 12-month cluster-randomised (1:1) controlled trial conducted between 2017 and 2018 in 25 primary healthcare centres from seven Spanish regions. The study took societal and healthcare provider perspectives. Patients included were between 45 and 75 years old and had any two of these three behaviours: smoking, insufficient physical activity or low adherence to Mediterranean dietary pattern. Intervention duration was 12 months and combined three action levels (individual, group and community). MHBC, defined as a change in at least two health risk behaviours, and cardiovascular risk (expressed in % points) were the outcomes used to calculate incremental cost-effectiveness ratios (ICER). Quality-adjusted life-years (QALYs) were estimated and used to calculate incremental cost-utility ratios (ICUR). Missing data was imputed and bootstrapping with 1000 replications was used to handle uncertainty in the modelling results. RESULTS: The study included 3062 participants. Intervention costs were €295 higher than usual care costs. Five per-cent additional patients in the intervention group did a MHBC compared to usual care patients. Differences in QALYS or cardiovascular risk between-group were close to 0 (- 0.01 and 0.04 respectively). The ICER was €5598 per extra health behaviour change in one patient and €6926 per one-point reduction in cardiovascular risk from a societal perspective. The cost-utility analysis showed that the intervention increased costs and has no effect, in terms of QALYs, compared to usual care from a societal perspective. Cost-utility planes showed high uncertainty surrounding the ICUR. Sensitivity analysis showed results in line with the main analysis. CONCLUSION: The efficiency of EIRA intervention cannot be fully established and its recommendation should be conditioned by results on medium-long term effects. TRIAL REGISTRATION: Clinicaltrials.gov NCT03136211 . Registered 02 May 2017 - Retrospectively registered.},
  author = {Aznar-Lou, I. and Zabaleta-Del-Olmo, E. and Casajuana-Closas, M. and Sánchez-Viñas, A. and Parody-Rúa, E. and Bolíbar, B. and Iracheta-Todó, M. and Bulilete, O. and López-Jiménez, T. and Pombo-Ramos, H. and Martín Miguel, M. V. and Magallón-Botaya, R. and Maderuelo-Fernández, JÁ and Motrico, E. and Bellón, J. and Martí-Lluch, R. and Rubio-Valera, M. and Serrano-Blanco, A.},
  journal = {Int J Behav Nutr Phys Act},
  keywords = {grapp-caib},
  number = 1,
  pages = 88,
  title = {Cost-effectiveness analysis of a multiple health behaviour change intervention in people aged between 45 and 75 years: a cluster randomized controlled trial in primary care (EIRA study)},
  type = {Journal Article},
  volume = 18,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN19
  %A Aznar-Lou, I.
  %A Zabaleta-Del-Olmo, E.
  %A Casajuana-Closas, M.
  %A Sánchez-Viñas, A.
  %A Parody-Rúa, E.
  %A Bolíbar, B.
  %A Iracheta-Todó, M.
  %A Bulilete, O.
  %A López-Jiménez, T.
  %A Pombo-Ramos, H.
  %A Martín Miguel, M. V.
  %A Magallón-Botaya, R.
  %A Maderuelo-Fernández, JÁ
  %A Motrico, E.
  %A Bellón, J.
  %A Martí-Lluch, R.
  %A Rubio-Valera, M.
  %A Serrano-Blanco, A.
  %D 2021
  %J Int J Behav Nutr Phys Act
  %N 1
  %P 88
  %R 10.1186/s12966-021-01144-5
  %T Cost-effectiveness analysis of a multiple health behaviour change intervention in people aged between 45 and 75 years: a cluster randomized controlled trial in primary care (EIRA study)
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254273/pdf/12966_2021_Article_1144.pdf
  %V 18
  %X BACKGROUND: Multiple health behaviour change (MHBC) interventions that promote healthy lifestyles may be an efficient approach in the prevention or treatment of chronic diseases in primary care. This study aims to evaluate the cost-utility and cost-effectiveness of the health promotion EIRA intervention in terms of MHBC and cardiovascular reduction. METHODS: An economic evaluation alongside a 12-month cluster-randomised (1:1) controlled trial conducted between 2017 and 2018 in 25 primary healthcare centres from seven Spanish regions. The study took societal and healthcare provider perspectives. Patients included were between 45 and 75 years old and had any two of these three behaviours: smoking, insufficient physical activity or low adherence to Mediterranean dietary pattern. Intervention duration was 12 months and combined three action levels (individual, group and community). MHBC, defined as a change in at least two health risk behaviours, and cardiovascular risk (expressed in % points) were the outcomes used to calculate incremental cost-effectiveness ratios (ICER). Quality-adjusted life-years (QALYs) were estimated and used to calculate incremental cost-utility ratios (ICUR). Missing data was imputed and bootstrapping with 1000 replications was used to handle uncertainty in the modelling results. RESULTS: The study included 3062 participants. Intervention costs were €295 higher than usual care costs. Five per-cent additional patients in the intervention group did a MHBC compared to usual care patients. Differences in QALYS or cardiovascular risk between-group were close to 0 (- 0.01 and 0.04 respectively). The ICER was €5598 per extra health behaviour change in one patient and €6926 per one-point reduction in cardiovascular risk from a societal perspective. The cost-utility analysis showed that the intervention increased costs and has no effect, in terms of QALYs, compared to usual care from a societal perspective. Cost-utility planes showed high uncertainty surrounding the ICUR. Sensitivity analysis showed results in line with the main analysis. CONCLUSION: The efficiency of EIRA intervention cannot be fully established and its recommendation should be conditioned by results on medium-long term effects. TRIAL REGISTRATION: Clinicaltrials.gov NCT03136211 . Registered 02 May 2017 - Retrospectively registered.
  

• 
  1.

  Arias de la Torre J, Vilagut G, Ronaldson A, Dregan A, Ricci-Cabello I, Hatch SL, Serrano-Blanco A, Valderas JM, Hotopf M, Alonso J. Prevalence and age patterns of depression in the United Kingdom. A population-based study. Journal of Affective Disorders [Internet]. 2021;279:164-72. https://www.sciencedirect.com/science/article/pii/S0165032720328263

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Methods A representative sample of the UK population (n=17,152) from the European Health Interview Survey of 2014 was included in the analyses. The Patient Health Questionnaire (PHQ-8) was used to assess the prevalence of depressive symptoms and of probable depressive disorder. Prevalence estimates (95%CI) were calculated. The association between prevalence and age was assessed using multivariable multinomial logistic and logistic regression models. All analyses were carried out for the total sample and stratified by sex. Results The prevalence of depressive symptoms ranged from 11.3% (10.6-11.9) for mild, to 3.3% (3.0-3.7) for severe symptoms. The prevalence of probable depressive disorder was 7.5% (95%CI: 7.0-8.0). A significantly higher prevalence of probable depressive disorder was found in those aged 45 to 59 years old compared with those aged 16 to 29. For the prevalence of severe depressive symptoms those age differences were even higher: 2.55 times higher (5.38 for men and 1.75 for women). Limitations The cross-sectional design precludes stablishing the direction of the relationship between age and the prevalence. Conclusions The prevalence and age patterns of depression in the UK were described. A peak in the prevalence was identified during middle adulthood. These results could serve as a reference for the monitoring of depression in the UK and the development of preventive strategies, particularly in the high-risk population groups identified.

  @article{ARIASDELATORRE2021164,
  abstract = {Methods A representative sample of the UK population (n=17,152) from the European Health Interview Survey of 2014 was included in the analyses. The Patient Health Questionnaire (PHQ-8) was used to assess the prevalence of depressive symptoms and of probable depressive disorder. Prevalence estimates (95%CI) were calculated. The association between prevalence and age was assessed using multivariable multinomial logistic and logistic regression models. All analyses were carried out for the total sample and stratified by sex. Results The prevalence of depressive symptoms ranged from 11.3% (10.6-11.9) for mild, to 3.3% (3.0-3.7) for severe symptoms. The prevalence of probable depressive disorder was 7.5% (95%CI: 7.0-8.0). A significantly higher prevalence of probable depressive disorder was found in those aged 45 to 59 years old compared with those aged 16 to 29. For the prevalence of severe depressive symptoms those age differences were even higher: 2.55 times higher (5.38 for men and 1.75 for women). Limitations The cross-sectional design precludes stablishing the direction of the relationship between age and the prevalence. Conclusions The prevalence and age patterns of depression in the UK were described. A peak in the prevalence was identified during middle adulthood. These results could serve as a reference for the monitoring of depression in the UK and the development of preventive strategies, particularly in the high-risk population groups identified.},
  author = {Arias de la Torre, Jorge and Vilagut, Gemma and Ronaldson, Amy and Dregan, Alex and Ricci-Cabello, Ignacio and Hatch, Stephani L and Serrano-Blanco, Antoni and Valderas, Jose M and Hotopf, Matthew and Alonso, Jordi},
  journal = {Journal of Affective Disorders},
  keywords = {grapp-caib myown},
  pages = {164-172},
  title = {Prevalence and age patterns of depression in the United Kingdom. A population-based study},
  volume = 279,
  year = 2021
  }
  

  %0 Journal Article
  %1 ARIASDELATORRE2021164
  %A Arias de la Torre, Jorge
  %A Vilagut, Gemma
  %A Ronaldson, Amy
  %A Dregan, Alex
  %A Ricci-Cabello, Ignacio
  %A Hatch, Stephani L
  %A Serrano-Blanco, Antoni
  %A Valderas, Jose M
  %A Hotopf, Matthew
  %A Alonso, Jordi
  %D 2021
  %J Journal of Affective Disorders
  %P 164-172
  %R https://doi.org/10.1016/j.jad.2020.09.129
  %T Prevalence and age patterns of depression in the United Kingdom. A population-based study
  %U https://www.sciencedirect.com/science/article/pii/S0165032720328263
  %V 279
  %X Methods A representative sample of the UK population (n=17,152) from the European Health Interview Survey of 2014 was included in the analyses. The Patient Health Questionnaire (PHQ-8) was used to assess the prevalence of depressive symptoms and of probable depressive disorder. Prevalence estimates (95%CI) were calculated. The association between prevalence and age was assessed using multivariable multinomial logistic and logistic regression models. All analyses were carried out for the total sample and stratified by sex. Results The prevalence of depressive symptoms ranged from 11.3% (10.6-11.9) for mild, to 3.3% (3.0-3.7) for severe symptoms. The prevalence of probable depressive disorder was 7.5% (95%CI: 7.0-8.0). A significantly higher prevalence of probable depressive disorder was found in those aged 45 to 59 years old compared with those aged 16 to 29. For the prevalence of severe depressive symptoms those age differences were even higher: 2.55 times higher (5.38 for men and 1.75 for women). Limitations The cross-sectional design precludes stablishing the direction of the relationship between age and the prevalence. Conclusions The prevalence and age patterns of depression in the UK were described. A peak in the prevalence was identified during middle adulthood. These results could serve as a reference for the monitoring of depression in the UK and the development of preventive strategies, particularly in the high-risk population groups identified.
  

• 
  1.

  Martínez-Sotelo J, Pinteño-Blanco M, García-Ramos R, Llobera-Cànaves J, Cadavid-Torres MI. Pharmacist-led intervention on potentially inappropriate prescription in patients with polypharmacy: PHARM-PC clinical trial protocol. Farm Hosp. 2021;45(4):210-5.

  AbstractBibTeXEndNoteDOIBibSonomy

  OBJECTIVE: Polypharmacy and potentially inappropriate medications (that  is, those associated with an unfavorable risk-benefit ratio) are common concerns in the context of elderly patients treated in primary care as they may increase the risk of morbidity and mortality, as well as  healthcare costs. Several studies have assessed the impact of pharmacist- led systematic reviews with respect to prescription appropriateness, health outcomes and/or costs. However, no cluster-randomized controlled  trial has been identified that provides an overall assessment of these  variables. The objective is to determine the effectiveness of a pharmacist- led systematic medication review in reducing the mean number and proportion of patients on potentially inappropriate medications (primary  goal); as well as in decreasing morbidity and mortality and the cost of  medications and the use of healthcare resources (secondary goals). METHOD: An open-label, cluster-randomized controlled trial will be conducted; where primary care physicians will be randomized either to receive (intervention group) or not to receive pharmacist  recommendations to withdraw potentially inappropriate medications  detected through the combined use of explicit and implicit criteria (control  group). Primary end-points will be the proportion of patients on potentially inappropriate medications and the mean number of such medications per  patient. Secondary endpoints will be healthcare resources used, the  proportion of patients who die and the mean number of days survived, as  well as the cost of medications and cost of healthcare resources used. CONCLUSIONS: In line with similar reports and based on our study´s design, we hope to obtain statistically significant reductions in the use  of potentially inappropriate medications and in medication costs overall.  We do not however expect to obtain significant reductions in  morbimortality or the cost of health resources employed.

  @article{RN168,
  abstract = {OBJECTIVE: Polypharmacy and potentially inappropriate medications (that  is, those associated with an unfavorable risk-benefit ratio) are common concerns in the context of elderly patients treated in primary care as they may increase the risk of morbidity and mortality, as well as  healthcare costs. Several studies have assessed the impact of pharmacist- led systematic reviews with respect to prescription appropriateness, health outcomes and/or costs. However, no cluster-randomized controlled  trial has been identified that provides an overall assessment of these  variables. The objective is to determine the effectiveness of a pharmacist- led systematic medication review in reducing the mean number and proportion of patients on potentially inappropriate medications (primary  goal); as well as in decreasing morbidity and mortality and the cost of  medications and the use of healthcare resources (secondary goals). METHOD: An open-label, cluster-randomized controlled trial will be conducted; where primary care physicians will be randomized either to receive (intervention group) or not to receive pharmacist  recommendations to withdraw potentially inappropriate medications  detected through the combined use of explicit and implicit criteria (control  group). Primary end-points will be the proportion of patients on potentially inappropriate medications and the mean number of such medications per  patient. Secondary endpoints will be healthcare resources used, the  proportion of patients who die and the mean number of days survived, as  well as the cost of medications and cost of healthcare resources used. CONCLUSIONS: In line with similar reports and based on our study´s design, we hope to obtain statistically significant reductions in the use  of potentially inappropriate medications and in medication costs overall.  We do not however expect to obtain significant reductions in  morbimortality or the cost of health resources employed.},
  author = {Martínez-Sotelo, J. and Pinteño-Blanco, M. and García-Ramos, R. and Llobera-Cànaves, J. and Cadavid-Torres, M. I.},
  journal = {Farm Hosp},
  keywords = {grapp-caib},
  number = 4,
  pages = {210-215},
  title = {Pharmacist-led intervention on potentially inappropriate prescription in patients with polypharmacy: PHARM-PC clinical trial protocol},
  type = {Journal Article},
  volume = 45,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN168
  %A Martínez-Sotelo, J.
  %A Pinteño-Blanco, M.
  %A García-Ramos, R.
  %A Llobera-Cànaves, J.
  %A Cadavid-Torres, M. I.
  %D 2021
  %J Farm Hosp
  %N 4
  %P 210-215
  %R 10.7399/fh.11575
  %T Pharmacist-led intervention on potentially inappropriate prescription in patients with polypharmacy: PHARM-PC clinical trial protocol
  %V 45
  %X OBJECTIVE: Polypharmacy and potentially inappropriate medications (that  is, those associated with an unfavorable risk-benefit ratio) are common concerns in the context of elderly patients treated in primary care as they may increase the risk of morbidity and mortality, as well as  healthcare costs. Several studies have assessed the impact of pharmacist- led systematic reviews with respect to prescription appropriateness, health outcomes and/or costs. However, no cluster-randomized controlled  trial has been identified that provides an overall assessment of these  variables. The objective is to determine the effectiveness of a pharmacist- led systematic medication review in reducing the mean number and proportion of patients on potentially inappropriate medications (primary  goal); as well as in decreasing morbidity and mortality and the cost of  medications and the use of healthcare resources (secondary goals). METHOD: An open-label, cluster-randomized controlled trial will be conducted; where primary care physicians will be randomized either to receive (intervention group) or not to receive pharmacist  recommendations to withdraw potentially inappropriate medications  detected through the combined use of explicit and implicit criteria (control  group). Primary end-points will be the proportion of patients on potentially inappropriate medications and the mean number of such medications per  patient. Secondary endpoints will be healthcare resources used, the  proportion of patients who die and the mean number of days survived, as  well as the cost of medications and cost of healthcare resources used. CONCLUSIONS: In line with similar reports and based on our study´s design, we hope to obtain statistically significant reductions in the use  of potentially inappropriate medications and in medication costs overall.  We do not however expect to obtain significant reductions in  morbimortality or the cost of health resources employed.
  

• 
  1.

  Navas A, Carrascosa MDC, Artigues C, Ortas S, Portells E, Soler A, Yañez AM, Bennasar-Veny M, Leiva A. Effectiveness of Moderate-Intensity Aerobic Water Exercise during Pregnancy on Quality of Life and Postpartum Depression: A Multi-Center, Randomized Controlled Trial. J Clin Med. 2021;10(11).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: The global prevalence of postpartum depression is about 20%. This disease has serious consequences for women, their infants, and their families. The aim of this randomized clinical trial was to analyze the effectiveness and safety of a moderate-intensity aerobic water exercise program on postpartum depression, sleep problems, and quality of life in women at one month after delivery. METHODS: This was a multi-center, parallel, randomized, evaluator blinded, controlled trial in a primary care setting. Pregnant women (14-20 weeks gestational age) who had low risk of complications and were from five primary care centers in the area covered by the obstetrics unit of Son Llatzer Hospital (Mallorca, Spain) were invited to participate. A total of 320 pregnant women were randomly assigned to two groups, an intervention group (moderate aquatic aerobic exercise) and a control group (usual prenatal care). One month after birth, sleep quality (MOS sleep), quality of life (EQ-5D), and presence of anxiety or depression (EPDS) were recorded. FINDINGS: Women in the intervention group were less likely to report anxiety or depression on the EQ5D (11.5% vs. 22.7%; p < 0.05) and had a lower mean EPDS score (6.1 ± 1.9 vs. 6.8 ± 2.4, p < 0.010). The two groups had no significant differences in other outcomes, maternal adverse events, and indicators of the newborn status. CONCLUSION: Moderate-intensity aquatic exercise during pregnancy decreased postpartum anxiety and depressive symptoms in mothers and was safe for mothers and their newborns.

  @article{RN169,
  abstract = {BACKGROUND: The global prevalence of postpartum depression is about 20%. This disease has serious consequences for women, their infants, and their families. The aim of this randomized clinical trial was to analyze the effectiveness and safety of a moderate-intensity aerobic water exercise program on postpartum depression, sleep problems, and quality of life in women at one month after delivery. METHODS: This was a multi-center, parallel, randomized, evaluator blinded, controlled trial in a primary care setting. Pregnant women (14-20 weeks gestational age) who had low risk of complications and were from five primary care centers in the area covered by the obstetrics unit of Son Llatzer Hospital (Mallorca, Spain) were invited to participate. A total of 320 pregnant women were randomly assigned to two groups, an intervention group (moderate aquatic aerobic exercise) and a control group (usual prenatal care). One month after birth, sleep quality (MOS sleep), quality of life (EQ-5D), and presence of anxiety or depression (EPDS) were recorded. FINDINGS: Women in the intervention group were less likely to report anxiety or depression on the EQ5D (11.5% vs. 22.7%; p < 0.05) and had a lower mean EPDS score (6.1 ± 1.9 vs. 6.8 ± 2.4, p < 0.010). The two groups had no significant differences in other outcomes, maternal adverse events, and indicators of the newborn status. CONCLUSION: Moderate-intensity aquatic exercise during pregnancy decreased postpartum anxiety and depressive symptoms in mothers and was safe for mothers and their newborns.},
  author = {Navas, A. and Carrascosa, M. D. C. and Artigues, C. and Ortas, S. and Portells, E. and Soler, A. and Yañez, A. M. and Bennasar-Veny, M. and Leiva, A.},
  journal = {J Clin Med},
  keywords = {grapp-caib},
  number = 11,
  title = {Effectiveness of Moderate-Intensity Aerobic Water Exercise during Pregnancy on Quality of Life and Postpartum Depression: A Multi-Center, Randomized Controlled Trial},
  type = {Journal Article},
  volume = 10,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN169
  %A Navas, A.
  %A Carrascosa, M. D. C.
  %A Artigues, C.
  %A Ortas, S.
  %A Portells, E.
  %A Soler, A.
  %A Yañez, A. M.
  %A Bennasar-Veny, M.
  %A Leiva, A.
  %D 2021
  %J J Clin Med
  %N 11
  %R 10.3390/jcm10112432
  %T Effectiveness of Moderate-Intensity Aerobic Water Exercise during Pregnancy on Quality of Life and Postpartum Depression: A Multi-Center, Randomized Controlled Trial
  %V 10
  %X BACKGROUND: The global prevalence of postpartum depression is about 20%. This disease has serious consequences for women, their infants, and their families. The aim of this randomized clinical trial was to analyze the effectiveness and safety of a moderate-intensity aerobic water exercise program on postpartum depression, sleep problems, and quality of life in women at one month after delivery. METHODS: This was a multi-center, parallel, randomized, evaluator blinded, controlled trial in a primary care setting. Pregnant women (14-20 weeks gestational age) who had low risk of complications and were from five primary care centers in the area covered by the obstetrics unit of Son Llatzer Hospital (Mallorca, Spain) were invited to participate. A total of 320 pregnant women were randomly assigned to two groups, an intervention group (moderate aquatic aerobic exercise) and a control group (usual prenatal care). One month after birth, sleep quality (MOS sleep), quality of life (EQ-5D), and presence of anxiety or depression (EPDS) were recorded. FINDINGS: Women in the intervention group were less likely to report anxiety or depression on the EQ5D (11.5% vs. 22.7%; p < 0.05) and had a lower mean EPDS score (6.1 ± 1.9 vs. 6.8 ± 2.4, p < 0.010). The two groups had no significant differences in other outcomes, maternal adverse events, and indicators of the newborn status. CONCLUSION: Moderate-intensity aquatic exercise during pregnancy decreased postpartum anxiety and depressive symptoms in mothers and was safe for mothers and their newborns.
  

• 
  1.

  Serrano-Ripoll MJ, Zamanillo-Campos R, Castro A, Fiol-de Roque MA, Ricci-Cabello I. Insomnia and sleep quality in healthcare workers fighting against COVID-19: a systematic review of the literature and meta-analysis. Actas Esp Psiquiatr. 2021;49(4):155-79.

  AbstractBibTeXEndNoteBibSonomyDownload

  The COVID-19 pandemic has the potential to significant- ly affect the mental health of healthcare workers, who stand in the frontline of this crisis. Insomnia is often related to exposure to stressful situations, such as the current health crisis, as well as other mental disorders, physical conditions and work-related problems. The objectives of this systematic review were: 1) to examine the impact of the current health pandemic produced by COVID-19 on insomnia and sleep quality of health professionals, and 2) to identify risk factors associated with insomnia. After a literature search in MEDLINE, EMBASE, and PsycINFO, 18 relevant studies were identified. The prevalence of insomnia estimated by random effects meta-analysis was 38% (95%CI= 37 to 39%), being slightly higher in women (29%, 95%CI= 27% to 30%) than in men (24%, 95%CI= 21 to 27%). The main risk factor associated with insomnia was working in a high-risk environment, followed by female sex and having a lower educational level. The high figures of self-reported insomnia and poor sleep quality observed indicate the need to develop interventions aimed at mitigating and caring for the mental health of healthcare workers fighting against this pandemic.

  @article{RN179,
  abstract = {The COVID-19 pandemic has the potential to significant- ly affect the mental health of healthcare workers, who stand in the frontline of this crisis. Insomnia is often related to exposure to stressful situations, such as the current health crisis, as well as other mental disorders, physical conditions and work-related problems. The objectives of this systematic review were: 1) to examine the impact of the current health pandemic produced by COVID-19 on insomnia and sleep quality of health professionals, and 2) to identify risk factors associated with insomnia. After a literature search in MEDLINE, EMBASE, and PsycINFO, 18 relevant studies were identified. The prevalence of insomnia estimated by random effects meta-analysis was 38% (95%CI= 37 to 39%), being slightly higher in women (29%, 95%CI= 27% to 30%) than in men (24%, 95%CI= 21 to 27%). The main risk factor associated with insomnia was working in a high-risk environment, followed by female sex and having a lower educational level. The high figures of self-reported insomnia and poor sleep quality observed indicate the need to develop interventions aimed at mitigating and caring for the mental health of healthcare workers fighting against this pandemic.},
  author = {Serrano-Ripoll, M. J. and Zamanillo-Campos, R. and Castro, A. and Fiol-de Roque, M. A. and Ricci-Cabello, I.},
  journal = {Actas Esp Psiquiatr},
  keywords = {grapp-caib},
  number = 4,
  pages = {155-179},
  title = {Insomnia and sleep quality in healthcare workers fighting against COVID-19: a systematic review of the literature and meta-analysis},
  type = {Journal Article},
  volume = 49,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN179
  %A Serrano-Ripoll, M. J.
  %A Zamanillo-Campos, R.
  %A Castro, A.
  %A Fiol-de Roque, M. A.
  %A Ricci-Cabello, I.
  %D 2021
  %J Actas Esp Psiquiatr
  %N 4
  %P 155-179
  %T Insomnia and sleep quality in healthcare workers fighting against COVID-19: a systematic review of the literature and meta-analysis
  %V 49
  %X The COVID-19 pandemic has the potential to significant- ly affect the mental health of healthcare workers, who stand in the frontline of this crisis. Insomnia is often related to exposure to stressful situations, such as the current health crisis, as well as other mental disorders, physical conditions and work-related problems. The objectives of this systematic review were: 1) to examine the impact of the current health pandemic produced by COVID-19 on insomnia and sleep quality of health professionals, and 2) to identify risk factors associated with insomnia. After a literature search in MEDLINE, EMBASE, and PsycINFO, 18 relevant studies were identified. The prevalence of insomnia estimated by random effects meta-analysis was 38% (95%CI= 37 to 39%), being slightly higher in women (29%, 95%CI= 27% to 30%) than in men (24%, 95%CI= 21 to 27%). The main risk factor associated with insomnia was working in a high-risk environment, followed by female sex and having a lower educational level. The high figures of self-reported insomnia and poor sleep quality observed indicate the need to develop interventions aimed at mitigating and caring for the mental health of healthcare workers fighting against this pandemic.
  

• 
  1.

  Fraile Navarro D, López García-Franco A, Niño de Guzmán E, Rabassa M, Zamanillo Campos R, Pardo-Hernández H, Ricci-Cabello I, Canelo-Aybar C, Meneses-Echavez JF, Yepes-Nuñez JJ, Kuindersma J, Gich Saladich I, Alonso-Coello P. Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors. Int J Clin Pract. 2021;75(11):e14805.

  AbstractBibTeXEndNoteDOIBibSonomy

  BACKGROUND: Vitamin D has been widely promoted for bone health through supplementation and fortification of the general adult population. However, there is growing evidence that does not support these strategies. Our aim is to review the quality and recommendations on vitamin D nutritional and clinical practice guidelines and to explore predictive factors for their direction and strength. METHODS: We searched three databases and two guideline repositories from 2010 onwards. We performed a descriptive analysis, a quality appraisal using AGREE II scores (Appraisal of Guidelines Research and Evaluation) and a bivariate analysis evaluating the association between direction and strength of recommendations, AGREE II domains' scores and pre-specified characteristics. RESULTS: We included 34 guidelines, 44.1% recommended, 26.5% suggested and 29.4% did not recommend vitamin D supplementation. Guidelines that scored higher for "editorial independence" and "overall quality score" were less likely to recommend or suggest vitamin D supplementation (median 68.8 vs 35.4; P = .001 and 58.3 vs 37.5; P = .02). Guidance produced by government organisations and those that reported source of funding were associated with higher AGREE II scores. Unclear role of source of funding was associated with recommending or suggesting vitamin D supplementation (P = .034). Editorial independence was an independent predictor for recommending or suggesting vitamin D supplementation (OR 1.09; CI95% 1.02 to 1.16; P = .006). CONCLUSIONS: Policymakers, clinicians and patients should be aware that lower quality guidelines and those reporting conflicts of interest are more likely to promote vitamin D supplementation. Guideline organisations should improve the quality of their recommendations' development and the management of conflicts of interest. Users and editors should be aware of these findings when using and appraising guidelines.

  @article{RN160,
  abstract = {BACKGROUND: Vitamin D has been widely promoted for bone health through supplementation and fortification of the general adult population. However, there is growing evidence that does not support these strategies. Our aim is to review the quality and recommendations on vitamin D nutritional and clinical practice guidelines and to explore predictive factors for their direction and strength. METHODS: We searched three databases and two guideline repositories from 2010 onwards. We performed a descriptive analysis, a quality appraisal using AGREE II scores (Appraisal of Guidelines Research and Evaluation) and a bivariate analysis evaluating the association between direction and strength of recommendations, AGREE II domains' scores and pre-specified characteristics. RESULTS: We included 34 guidelines, 44.1% recommended, 26.5% suggested and 29.4% did not recommend vitamin D supplementation. Guidelines that scored higher for "editorial independence" and "overall quality score" were less likely to recommend or suggest vitamin D supplementation (median 68.8 vs 35.4; P = .001 and 58.3 vs 37.5; P = .02). Guidance produced by government organisations and those that reported source of funding were associated with higher AGREE II scores. Unclear role of source of funding was associated with recommending or suggesting vitamin D supplementation (P = .034). Editorial independence was an independent predictor for recommending or suggesting vitamin D supplementation (OR 1.09; CI95% 1.02 to 1.16; P = .006). CONCLUSIONS: Policymakers, clinicians and patients should be aware that lower quality guidelines and those reporting conflicts of interest are more likely to promote vitamin D supplementation. Guideline organisations should improve the quality of their recommendations' development and the management of conflicts of interest. Users and editors should be aware of these findings when using and appraising guidelines.},
  author = {Fraile Navarro, D. and López García-Franco, A. and Niño de Guzmán, E. and Rabassa, M. and Zamanillo Campos, R. and Pardo-Hernández, H. and Ricci-Cabello, I. and Canelo-Aybar, C. and Meneses-Echavez, J. F. and Yepes-Nuñez, J. J. and Kuindersma, J. and Gich Saladich, I. and Alonso-Coello, P.},
  journal = {Int J Clin Pract},
  keywords = {grapp-caib myown},
  number = 11,
  pages = {e14805},
  title = {Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors},
  type = {Journal Article},
  volume = 75,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN160
  %A Fraile Navarro, D.
  %A López García-Franco, A.
  %A Niño de Guzmán, E.
  %A Rabassa, M.
  %A Zamanillo Campos, R.
  %A Pardo-Hernández, H.
  %A Ricci-Cabello, I.
  %A Canelo-Aybar, C.
  %A Meneses-Echavez, J. F.
  %A Yepes-Nuñez, J. J.
  %A Kuindersma, J.
  %A Gich Saladich, I.
  %A Alonso-Coello, P.
  %D 2021
  %J Int J Clin Pract
  %N 11
  %P e14805
  %R 10.1111/ijcp.14805
  %T Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors
  %V 75
  %X BACKGROUND: Vitamin D has been widely promoted for bone health through supplementation and fortification of the general adult population. However, there is growing evidence that does not support these strategies. Our aim is to review the quality and recommendations on vitamin D nutritional and clinical practice guidelines and to explore predictive factors for their direction and strength. METHODS: We searched three databases and two guideline repositories from 2010 onwards. We performed a descriptive analysis, a quality appraisal using AGREE II scores (Appraisal of Guidelines Research and Evaluation) and a bivariate analysis evaluating the association between direction and strength of recommendations, AGREE II domains' scores and pre-specified characteristics. RESULTS: We included 34 guidelines, 44.1% recommended, 26.5% suggested and 29.4% did not recommend vitamin D supplementation. Guidelines that scored higher for "editorial independence" and "overall quality score" were less likely to recommend or suggest vitamin D supplementation (median 68.8 vs 35.4; P = .001 and 58.3 vs 37.5; P = .02). Guidance produced by government organisations and those that reported source of funding were associated with higher AGREE II scores. Unclear role of source of funding was associated with recommending or suggesting vitamin D supplementation (P = .034). Editorial independence was an independent predictor for recommending or suggesting vitamin D supplementation (OR 1.09; CI95% 1.02 to 1.16; P = .006). CONCLUSIONS: Policymakers, clinicians and patients should be aware that lower quality guidelines and those reporting conflicts of interest are more likely to promote vitamin D supplementation. Guideline organisations should improve the quality of their recommendations' development and the management of conflicts of interest. Users and editors should be aware of these findings when using and appraising guidelines.
  

2020

• 
  1.

  Gómez-Gómez I, Moreno-Peral P, López T, Claver’ia A, Oliván B, Marti R, Llobera J, Maderuelo-Fernández J-A, Motrico E. Multiple risk behaviour intervention to prevent depression in primary care. British Journal of General Practice [Internet]. Royal College of General Practitioners; 2020 Jun.;70(suppl 1):bjgp20X711677. https://doi.org/10.3399%2Fbjgp20x711677

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUND: Primary care is the ideal setting for promotion and prevention intervention. Multiple risk behaviour interventions present several advantages over single-risk lifestyle interventions. Multiple risk behaviour interventions could be easily implemented in primary care to prevent non-communicable disease and depression. AIM: To test the effectiveness of a multiple risk behaviour intervention to promote Mediterranean diet, physical activity, and/or smoking cessation in people attending Spanish primary health care with incidence of depression and symptoms of depression. METHOD: This was a secondary analysis of the EIRA study that aims to test the effectiveness of a multiple risk behaviour intervention to promote healthy lifestyles. Twenty-six primary care centres were randomised to receive multiple risk behaviour intervention or usual care. The multiple risk behaviour intervention included individual sessions, group sessions, communitarian activities, and SMS reception. Participants were followed for 10-14 months. The primary outcomes of this study were incidence of depression and reductions of depressive symptoms. RESULTS: Three thousand and sixty-seven participants were included. Females accounted for 45.13% and 93.88% were Spanish. Age varied between 45 and 75 years old. The effectiveness of the intervention will be calculated using the Patient Health Questionnaire (PHQ-9) and the Composite International Diagnostic Interview (‎CIDI)‎ depression section. Linear and logistic regression will be used to create predictive models. CONCLUSION: Primary care is the most accessible service in the health system for patients. Hence primary care is the ideal setting for health education, promotion, and prevention interventions. This study will provide high-quality evidence about the effectiveness of multiple risk behaviour interventions over depression prevention.

  @article{G_mez_G_mez_2020,
  abstract = {BACKGROUND: Primary care is the ideal setting for promotion and prevention intervention. Multiple risk behaviour interventions present several advantages over single-risk lifestyle interventions. Multiple risk behaviour interventions could be easily implemented in primary care to prevent non-communicable disease and depression. AIM: To test the effectiveness of a multiple risk behaviour intervention to promote Mediterranean diet, physical activity, and/or smoking cessation in people attending Spanish primary health care with incidence of depression and symptoms of depression. METHOD: This was a secondary analysis of the EIRA study that aims to test the effectiveness of a multiple risk behaviour intervention to promote healthy lifestyles. Twenty-six primary care centres were randomised to receive multiple risk behaviour intervention or usual care. The multiple risk behaviour intervention included individual sessions, group sessions, communitarian activities, and SMS reception. Participants were followed for 10-14 months. The primary outcomes of this study were incidence of depression and reductions of depressive symptoms. RESULTS: Three thousand and sixty-seven participants were included. Females accounted for 45.13% and 93.88% were Spanish. Age varied between 45 and 75 years old. The effectiveness of the intervention will be calculated using the Patient Health Questionnaire (PHQ-9) and the Composite International Diagnostic Interview (‎CIDI)‎ depression section. Linear and logistic regression will be used to create predictive models. CONCLUSION: Primary care is the most accessible service in the health system for patients. Hence primary care is the ideal setting for health education, promotion, and prevention interventions. This study will provide high-quality evidence about the effectiveness of multiple risk behaviour interventions over depression prevention.},
  author = {Gómez-Gómez, Irene and Moreno-Peral, Patricia and López, Tomás and Claver'ia, Ana and Oliván, Barbara and Marti, Ruth and Llobera, Joan and Maderuelo-Fernández, Jose-Angel and Motrico, Emma},
  journal = {British Journal of General Practice},
  keywords = {grapp-caib},
  month = {jun},
  number = {suppl 1},
  pages = {bjgp20X711677},
  publisher = {Royal College of General Practitioners},
  title = {Multiple risk behaviour intervention to prevent depression in primary care},
  volume = 70,
  year = 2020
  }
  

  %0 Journal Article
  %1 G_mez_G_mez_2020
  %A Gómez-Gómez, Irene
  %A Moreno-Peral, Patricia
  %A López, Tomás
  %A Claver'ia, Ana
  %A Oliván, Barbara
  %A Marti, Ruth
  %A Llobera, Joan
  %A Maderuelo-Fernández, Jose-Angel
  %A Motrico, Emma
  %D 2020
  %I Royal College of General Practitioners
  %J British Journal of General Practice
  %N suppl 1
  %P bjgp20X711677
  %R 10.3399/bjgp20x711677
  %T Multiple risk behaviour intervention to prevent depression in primary care
  %U https://doi.org/10.3399%2Fbjgp20x711677
  %V 70
  %X BACKGROUND: Primary care is the ideal setting for promotion and prevention intervention. Multiple risk behaviour interventions present several advantages over single-risk lifestyle interventions. Multiple risk behaviour interventions could be easily implemented in primary care to prevent non-communicable disease and depression. AIM: To test the effectiveness of a multiple risk behaviour intervention to promote Mediterranean diet, physical activity, and/or smoking cessation in people attending Spanish primary health care with incidence of depression and symptoms of depression. METHOD: This was a secondary analysis of the EIRA study that aims to test the effectiveness of a multiple risk behaviour intervention to promote healthy lifestyles. Twenty-six primary care centres were randomised to receive multiple risk behaviour intervention or usual care. The multiple risk behaviour intervention included individual sessions, group sessions, communitarian activities, and SMS reception. Participants were followed for 10-14 months. The primary outcomes of this study were incidence of depression and reductions of depressive symptoms. RESULTS: Three thousand and sixty-seven participants were included. Females accounted for 45.13% and 93.88% were Spanish. Age varied between 45 and 75 years old. The effectiveness of the intervention will be calculated using the Patient Health Questionnaire (PHQ-9) and the Composite International Diagnostic Interview (‎CIDI)‎ depression section. Linear and logistic regression will be used to create predictive models. CONCLUSION: Primary care is the most accessible service in the health system for patients. Hence primary care is the ideal setting for health education, promotion, and prevention interventions. This study will provide high-quality evidence about the effectiveness of multiple risk behaviour interventions over depression prevention.
  

• 
  1.

  Chela-Alvarez X, Bulilete O, Garc’ia-Buades ME, Ferrer-Perez VA, Llobera-Canaves J. Perceived Factors of Stress and Its Outcomes among Hotel Housekeepers in the Balearic Islands: A Qualitative Approach from a Gender Perspective. International Journal of Environmental Research and Public Health [Internet]. MDPI AG; 2020 Dec.;18(1):52. https://doi.org/10.3390%2Fijerph18010052

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Tourism is the main economic sector in the Balearic Islands (Spain) and hotel housekeepers (HHs) are a large occupational group, in which stress is becoming a major issue. This study aims at exploring in-depth factors perceived as stressors by HHs and key-informants, and their effects on work-life balance (WLB). A qualitative design with phenomenological approach was used, conducting six focus groups with 34 HHs and 10 individual interviews with key-informants. Results were analyzed adopting the job demands-resources model and a gender perspective. High demands, e.g., work overload, time pressure, physical burden…, lack of enough resources and little control, derived from role conflict, unexpected events…, were the most important factors explaining HHs' stress. Additionally, this imbalance was perceived as leading to health problems, mainly musculoskeletal disorders. Working schedule was mentioned as a facilitator to WLB, whereas an imbalance between job demands and resources led to work-home conflict, preventing them from enjoying leisure time. Multiple roles at work and at home increased their stress. HHs experienced their job as invisible and unrecognised. Regarding practical implications, our recommendations for hotel organization include reducing workload and increasing resources, which would improve the job demands-resource balance, diminish negative mental and physical outcomes and improve WLB.

  @article{Chela_Alvarez_2020,
  abstract = {Tourism is the main economic sector in the Balearic Islands (Spain) and hotel housekeepers (HHs) are a large occupational group, in which stress is becoming a major issue. This study aims at exploring in-depth factors perceived as stressors by HHs and key-informants, and their effects on work-life balance (WLB). A qualitative design with phenomenological approach was used, conducting six focus groups with 34 HHs and 10 individual interviews with key-informants. Results were analyzed adopting the job demands-resources model and a gender perspective. High demands, e.g., work overload, time pressure, physical burden…, lack of enough resources and little control, derived from role conflict, unexpected events…, were the most important factors explaining HHs' stress. Additionally, this imbalance was perceived as leading to health problems, mainly musculoskeletal disorders. Working schedule was mentioned as a facilitator to WLB, whereas an imbalance between job demands and resources led to work-home conflict, preventing them from enjoying leisure time. Multiple roles at work and at home increased their stress. HHs experienced their job as invisible and unrecognised. Regarding practical implications, our recommendations for hotel organization include reducing workload and increasing resources, which would improve the job demands-resource balance, diminish negative mental and physical outcomes and improve WLB.},
  author = {Chela-Alvarez, Xenia and Bulilete, Oana and Garc'ia-Buades, M. Esther and Ferrer-Perez, Victoria A. and Llobera-Canaves, Joan},
  journal = {International Journal of Environmental Research and Public Health},
  keywords = {grapp-caib},
  month = {dec},
  number = 1,
  pages = 52,
  publisher = {MDPI AG},
  title = {Perceived Factors of Stress and Its Outcomes among Hotel Housekeepers in the Balearic Islands: A Qualitative Approach from a Gender Perspective},
  volume = 18,
  year = 2020
  }
  

  %0 Journal Article
  %1 Chela_Alvarez_2020
  %A Chela-Alvarez, Xenia
  %A Bulilete, Oana
  %A Garc'ia-Buades, M. Esther
  %A Ferrer-Perez, Victoria A.
  %A Llobera-Canaves, Joan
  %D 2020
  %I MDPI AG
  %J International Journal of Environmental Research and Public Health
  %N 1
  %P 52
  %R 10.3390/ijerph18010052
  %T Perceived Factors of Stress and Its Outcomes among Hotel Housekeepers in the Balearic Islands: A Qualitative Approach from a Gender Perspective
  %U https://doi.org/10.3390%2Fijerph18010052
  %V 18
  %X Tourism is the main economic sector in the Balearic Islands (Spain) and hotel housekeepers (HHs) are a large occupational group, in which stress is becoming a major issue. This study aims at exploring in-depth factors perceived as stressors by HHs and key-informants, and their effects on work-life balance (WLB). A qualitative design with phenomenological approach was used, conducting six focus groups with 34 HHs and 10 individual interviews with key-informants. Results were analyzed adopting the job demands-resources model and a gender perspective. High demands, e.g., work overload, time pressure, physical burden…, lack of enough resources and little control, derived from role conflict, unexpected events…, were the most important factors explaining HHs' stress. Additionally, this imbalance was perceived as leading to health problems, mainly musculoskeletal disorders. Working schedule was mentioned as a facilitator to WLB, whereas an imbalance between job demands and resources led to work-home conflict, preventing them from enjoying leisure time. Multiple roles at work and at home increased their stress. HHs experienced their job as invisible and unrecognised. Regarding practical implications, our recommendations for hotel organization include reducing workload and increasing resources, which would improve the job demands-resource balance, diminish negative mental and physical outcomes and improve WLB.
  

• 
  1.

  Pastor-Moreno G, Ruiz-Pérez I, Henares-Montiel J, Escribà-Agüir V, Higueras-Callejón C, Ricci-Cabello I. Intimate partner violence and perinatal health: a systematic review. Bjog [Internet]. 2020;127(5):537-4. https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.16084

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUND: Physical, psychological and sexual intimate partner violence (IPV) has been described in the literature as different types of IPV experienced by women during pregnancy all over the world. OBJECTIVES: To review and summarise systematically the empirical evidence on the links between IPV during pregnancy and the perinatal health of mothers and fetuses/neonates. SEARCH STRATEGY: MEDLINE (Ovid), CINAHL, Embase, Nursing@ovid (Ovid) and LILACS were searched (2008-2018). SELECTION CRITERIA: Observational studies that examined perinatal health outcomes (i.e. pre-term birth, low birthweight, miscarriage, perinatal death and premature rupture of membranes) in pregnant women exposed to IPV. DATA COLLECTION AND ANALYSIS: Information on study characteristics, type of IPV measured, study design, methodological quality and outcome variable extracted. RESULTS: Fifty studies were included. Twenty-nine analysed undifferentiated IPV (n = 25 489), 34 included physical IPV (n = 7333), 22 analysed psychological IPV (n = 7833) and 18 examined sexual IPV (n = 2388). Fifteen studies were from Asia, 12 from North America and Oceania, and 12 from Central and South America. The studies examined the association between IPV and 39 different perinatal health outcomes. The most frequent outcomes reported were pre-term birth (50%), low birthweight (46%), miscarriage (30%), perinatal death (20%) and premature rupture of membranes (20%). A significant association with perinatal health outcomes was reported by 12 of the studies analysing undifferentiated IPV, 18 physical IPV, six psychological IPV and two sexual IPV. CONCLUSIONS: The relation between IPV and perinatal health outcomes can be seen in different epidemiological designs and countries. In all, 39 different outcomes were identified and 29 were associated with IPV. TWEETABLE ABSTRACT: A variety of poor perinatal health outcomes are associated with psychological, physical and sexual IPV.

  @article{RN37,
  abstract = {BACKGROUND: Physical, psychological and sexual intimate partner violence (IPV) has been described in the literature as different types of IPV experienced by women during pregnancy all over the world. OBJECTIVES: To review and summarise systematically the empirical evidence on the links between IPV during pregnancy and the perinatal health of mothers and fetuses/neonates. SEARCH STRATEGY: MEDLINE (Ovid), CINAHL, Embase, Nursing@ovid (Ovid) and LILACS were searched (2008-2018). SELECTION CRITERIA: Observational studies that examined perinatal health outcomes (i.e. pre-term birth, low birthweight, miscarriage, perinatal death and premature rupture of membranes) in pregnant women exposed to IPV. DATA COLLECTION AND ANALYSIS: Information on study characteristics, type of IPV measured, study design, methodological quality and outcome variable extracted. RESULTS: Fifty studies were included. Twenty-nine analysed undifferentiated IPV (n = 25 489), 34 included physical IPV (n = 7333), 22 analysed psychological IPV (n = 7833) and 18 examined sexual IPV (n = 2388). Fifteen studies were from Asia, 12 from North America and Oceania, and 12 from Central and South America. The studies examined the association between IPV and 39 different perinatal health outcomes. The most frequent outcomes reported were pre-term birth (50%), low birthweight (46%), miscarriage (30%), perinatal death (20%) and premature rupture of membranes (20%). A significant association with perinatal health outcomes was reported by 12 of the studies analysing undifferentiated IPV, 18 physical IPV, six psychological IPV and two sexual IPV. CONCLUSIONS: The relation between IPV and perinatal health outcomes can be seen in different epidemiological designs and countries. In all, 39 different outcomes were identified and 29 were associated with IPV. TWEETABLE ABSTRACT: A variety of poor perinatal health outcomes are associated with psychological, physical and sexual IPV.},
  author = {Pastor-Moreno, G. and Ruiz-Pérez, I. and Henares-Montiel, J. and Escribà-Agüir, V. and Higueras-Callejón, C. and Ricci-Cabello, I.},
  journal = {Bjog},
  keywords = {grapp-caib},
  number = 5,
  pages = {537-547},
  title = {Intimate partner violence and perinatal health: a systematic review},
  type = {Journal Article},
  volume = 127,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN37
  %A Pastor-Moreno, G.
  %A Ruiz-Pérez, I.
  %A Henares-Montiel, J.
  %A Escribà-Agüir, V.
  %A Higueras-Callejón, C.
  %A Ricci-Cabello, I.
  %D 2020
  %J Bjog
  %N 5
  %P 537-547
  %R 10.1111/1471-0528.16084
  %T Intimate partner violence and perinatal health: a systematic review
  %U https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.16084
  %V 127
  %X BACKGROUND: Physical, psychological and sexual intimate partner violence (IPV) has been described in the literature as different types of IPV experienced by women during pregnancy all over the world. OBJECTIVES: To review and summarise systematically the empirical evidence on the links between IPV during pregnancy and the perinatal health of mothers and fetuses/neonates. SEARCH STRATEGY: MEDLINE (Ovid), CINAHL, Embase, Nursing@ovid (Ovid) and LILACS were searched (2008-2018). SELECTION CRITERIA: Observational studies that examined perinatal health outcomes (i.e. pre-term birth, low birthweight, miscarriage, perinatal death and premature rupture of membranes) in pregnant women exposed to IPV. DATA COLLECTION AND ANALYSIS: Information on study characteristics, type of IPV measured, study design, methodological quality and outcome variable extracted. RESULTS: Fifty studies were included. Twenty-nine analysed undifferentiated IPV (n = 25 489), 34 included physical IPV (n = 7333), 22 analysed psychological IPV (n = 7833) and 18 examined sexual IPV (n = 2388). Fifteen studies were from Asia, 12 from North America and Oceania, and 12 from Central and South America. The studies examined the association between IPV and 39 different perinatal health outcomes. The most frequent outcomes reported were pre-term birth (50%), low birthweight (46%), miscarriage (30%), perinatal death (20%) and premature rupture of membranes (20%). A significant association with perinatal health outcomes was reported by 12 of the studies analysing undifferentiated IPV, 18 physical IPV, six psychological IPV and two sexual IPV. CONCLUSIONS: The relation between IPV and perinatal health outcomes can be seen in different epidemiological designs and countries. In all, 39 different outcomes were identified and 29 were associated with IPV. TWEETABLE ABSTRACT: A variety of poor perinatal health outcomes are associated with psychological, physical and sexual IPV.
  

• 
  1.

  Philips EM, Santos S, Trasande L, Aurrekoetxea JJ, Barros H, von Berg A, Bergström A, Bird PK, Brescianini S, Ní Chaoimh C, Charles M-A, Chatzi L, Chevrier C, Chrousos GP, Costet N, Criswell R, Crozier S, Eggesbø M, Fantini MP, Farchi S, Forastiere F, van Gelder MMHJ, Georgiu V, Godfrey KM, Gori D, Hanke W, Heude B, Hryhorczuk D, Iñiguez C, Inskip H, Karvonen AM, Kenny LC, Kull I, Lawlor DA, Lehmann I, Magnus P, Manios Y, Melén E, Mommers M, Morgen CS, Moschonis G, Murray D, Nohr EA, Nybo Andersen A-M, Oken E, Oostvogels AJJM, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Rusconi F, Santos AC, Sørensen TIA, Standl M, Stoltenberg C, Sunyer J, Thiering E, Thijs C, Torrent M, Vrijkotte TGM, Wright J, Zvinchuk O, Gaillard R, Jaddoe VWV. Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births. PLOS Medicine [Internet]. Public Library of Science; 2020 Aug.;17(8):1-25. https://doi.org/10.1371/journal.pmed.1003182

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/birth cohorts from Europe and North America. All 28 cohorts had information on maternal smoking, and 16 also had information on paternal smoking. In total, 22 cohorts were population-based, with birth years ranging from 1991 to 2015. The mothers’ median age was 30.0 years, and most mothers were medium or highly educated. We used multilevel binary logistic regression models adjusted for maternal and paternal sociodemographic and lifestyle-related characteristics. Compared with nonsmoking mothers, maternal first trimester smoking only was not associated with adverse birth outcomes but was associated with a higher risk of childhood overweight (odds ratio [OR] 1.17 [95% CI 1.02–1.35], P value = 0.030). Children from mothers who continued smoking during pregnancy had higher risks of preterm birth (OR 1.08 [95% CI 1.02–1.15], P value = 0.012), small size for gestational age (OR 2.15 [95% CI 2.07–2.23], P value < 0.001), and childhood overweight (OR 1.42 [95% CI 1.35–1.48], P value < 0.001). Mothers who reduced the number of cigarettes between the first and third trimester, without quitting, still had a higher risk of small size for gestational age. However, the corresponding risk estimates were smaller than for women who continued the same amount of cigarettes throughout pregnancy (OR 1.89 [95% CI 1.52–2.34] instead of OR 2.20 [95% CI 2.02–2.42] when reducing from 5–9 to ≤4 cigarettes/day; OR 2.79 [95% CI 2.39–3.25] and OR 1.93 [95% CI 1.46–2.57] instead of OR 2.95 [95% CI 2.75–3.15] when reducing from ≥10 to 5–9 and ≤4 cigarettes/day, respectively [P values < 0.001]). Reducing the number of cigarettes during pregnancy did not affect the risks of preterm birth and childhood overweight. Among nonsmoking mothers, paternal smoking was associated with childhood overweight (OR 1.21 [95% CI 1.16–1.27], P value < 0.001) but not with adverse birth outcomes. Limitations of this study include the self-report of parental smoking information and the possibility of residual confounding. As this study only included participants from Europe and North America, results need to be carefully interpreted regarding other populations. Conclusions We observed that as compared to nonsmoking during pregnancy, quitting smoking in the first trimester is associated with the same risk of preterm birth and small size for gestational age, but with a higher risk of childhood overweight. Reducing the number of cigarettes, without quitting, has limited beneficial effects. Paternal smoking seems to be associated, independently of maternal smoking, with the risk of childhood overweight. Population strategies should focus on parental smoking prevention before or at the start, rather than during, pregnancy.

  @article{10.1371/journal.pmed.1003182,
  abstract = {Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/birth cohorts from Europe and North America. All 28 cohorts had information on maternal smoking, and 16 also had information on paternal smoking. In total, 22 cohorts were population-based, with birth years ranging from 1991 to 2015. The mothers’ median age was 30.0 years, and most mothers were medium or highly educated. We used multilevel binary logistic regression models adjusted for maternal and paternal sociodemographic and lifestyle-related characteristics. Compared with nonsmoking mothers, maternal first trimester smoking only was not associated with adverse birth outcomes but was associated with a higher risk of childhood overweight (odds ratio [OR] 1.17 [95% CI 1.02–1.35], P value = 0.030). Children from mothers who continued smoking during pregnancy had higher risks of preterm birth (OR 1.08 [95% CI 1.02–1.15], P value = 0.012), small size for gestational age (OR 2.15 [95% CI 2.07–2.23], P value < 0.001), and childhood overweight (OR 1.42 [95% CI 1.35–1.48], P value < 0.001). Mothers who reduced the number of cigarettes between the first and third trimester, without quitting, still had a higher risk of small size for gestational age. However, the corresponding risk estimates were smaller than for women who continued the same amount of cigarettes throughout pregnancy (OR 1.89 [95% CI 1.52–2.34] instead of OR 2.20 [95% CI 2.02–2.42] when reducing from 5–9 to ≤4 cigarettes/day; OR 2.79 [95% CI 2.39–3.25] and OR 1.93 [95% CI 1.46–2.57] instead of OR 2.95 [95% CI 2.75–3.15] when reducing from ≥10 to 5–9 and ≤4 cigarettes/day, respectively [P values < 0.001]). Reducing the number of cigarettes during pregnancy did not affect the risks of preterm birth and childhood overweight. Among nonsmoking mothers, paternal smoking was associated with childhood overweight (OR 1.21 [95% CI 1.16–1.27], P value < 0.001) but not with adverse birth outcomes. Limitations of this study include the self-report of parental smoking information and the possibility of residual confounding. As this study only included participants from Europe and North America, results need to be carefully interpreted regarding other populations. Conclusions We observed that as compared to nonsmoking during pregnancy, quitting smoking in the first trimester is associated with the same risk of preterm birth and small size for gestational age, but with a higher risk of childhood overweight. Reducing the number of cigarettes, without quitting, has limited beneficial effects. Paternal smoking seems to be associated, independently of maternal smoking, with the risk of childhood overweight. Population strategies should focus on parental smoking prevention before or at the start, rather than during, pregnancy.},
  author = {Philips, Elise M. and Santos, Susana and Trasande, Leonardo and Aurrekoetxea, Juan J. and Barros, Henrique and von Berg, Andrea and Bergström, Anna and Bird, Philippa K. and Brescianini, Sonia and Ní Chaoimh, Carol and Charles, Marie-Aline and Chatzi, Leda and Chevrier, Cécile and Chrousos, George P. and Costet, Nathalie and Criswell, Rachel and Crozier, Sarah and Eggesbø, Merete and Fantini, Maria Pia and Farchi, Sara and Forastiere, Francesco and van Gelder, Marleen M. H. J. and Georgiu, Vagelis and Godfrey, Keith M. and Gori, Davide and Hanke, Wojciech and Heude, Barbara and Hryhorczuk, Daniel and Iñiguez, Carmen and Inskip, Hazel and Karvonen, Anne M. and Kenny, Louise C. and Kull, Inger and Lawlor, Debbie A. and Lehmann, Irina and Magnus, Per and Manios, Yannis and Melén, Erik and Mommers, Monique and Morgen, Camilla S. and Moschonis, George and Murray, Deirdre and Nohr, Ellen A. and Nybo Andersen, Anne-Marie and Oken, Emily and Oostvogels, Adriëtte J. J. M. and Papadopoulou, Eleni and Pekkanen, Juha and Pizzi, Costanza and Polanska, Kinga and Porta, Daniela and Richiardi, Lorenzo and Rifas-Shiman, Sheryl L. and Roeleveld, Nel and Rusconi, Franca and Santos, Ana C. and Sørensen, Thorkild I. A. and Standl, Marie and Stoltenberg, Camilla and Sunyer, Jordi and Thiering, Elisabeth and Thijs, Carel and Torrent, Maties and Vrijkotte, Tanja G. M. and Wright, John and Zvinchuk, Oleksandr and Gaillard, Romy and Jaddoe, Vincent W. V.},
  journal = {PLOS Medicine},
  keywords = {grapp-caib},
  month = {08},
  number = 8,
  pages = {1-25},
  publisher = {Public Library of Science},
  title = {Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births},
  volume = 17,
  year = 2020
  }
  

  %0 Journal Article
  %1 10.1371/journal.pmed.1003182
  %A Philips, Elise M.
  %A Santos, Susana
  %A Trasande, Leonardo
  %A Aurrekoetxea, Juan J.
  %A Barros, Henrique
  %A von Berg, Andrea
  %A Bergström, Anna
  %A Bird, Philippa K.
  %A Brescianini, Sonia
  %A Ní Chaoimh, Carol
  %A Charles, Marie-Aline
  %A Chatzi, Leda
  %A Chevrier, Cécile
  %A Chrousos, George P.
  %A Costet, Nathalie
  %A Criswell, Rachel
  %A Crozier, Sarah
  %A Eggesbø, Merete
  %A Fantini, Maria Pia
  %A Farchi, Sara
  %A Forastiere, Francesco
  %A van Gelder, Marleen M. H. J.
  %A Georgiu, Vagelis
  %A Godfrey, Keith M.
  %A Gori, Davide
  %A Hanke, Wojciech
  %A Heude, Barbara
  %A Hryhorczuk, Daniel
  %A Iñiguez, Carmen
  %A Inskip, Hazel
  %A Karvonen, Anne M.
  %A Kenny, Louise C.
  %A Kull, Inger
  %A Lawlor, Debbie A.
  %A Lehmann, Irina
  %A Magnus, Per
  %A Manios, Yannis
  %A Melén, Erik
  %A Mommers, Monique
  %A Morgen, Camilla S.
  %A Moschonis, George
  %A Murray, Deirdre
  %A Nohr, Ellen A.
  %A Nybo Andersen, Anne-Marie
  %A Oken, Emily
  %A Oostvogels, Adriëtte J. J. M.
  %A Papadopoulou, Eleni
  %A Pekkanen, Juha
  %A Pizzi, Costanza
  %A Polanska, Kinga
  %A Porta, Daniela
  %A Richiardi, Lorenzo
  %A Rifas-Shiman, Sheryl L.
  %A Roeleveld, Nel
  %A Rusconi, Franca
  %A Santos, Ana C.
  %A Sørensen, Thorkild I. A.
  %A Standl, Marie
  %A Stoltenberg, Camilla
  %A Sunyer, Jordi
  %A Thiering, Elisabeth
  %A Thijs, Carel
  %A Torrent, Maties
  %A Vrijkotte, Tanja G. M.
  %A Wright, John
  %A Zvinchuk, Oleksandr
  %A Gaillard, Romy
  %A Jaddoe, Vincent W. V.
  %D 2020
  %I Public Library of Science
  %J PLOS Medicine
  %N 8
  %P 1-25
  %R 10.1371/journal.pmed.1003182
  %T Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births
  %U https://doi.org/10.1371/journal.pmed.1003182
  %V 17
  %X Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/birth cohorts from Europe and North America. All 28 cohorts had information on maternal smoking, and 16 also had information on paternal smoking. In total, 22 cohorts were population-based, with birth years ranging from 1991 to 2015. The mothers’ median age was 30.0 years, and most mothers were medium or highly educated. We used multilevel binary logistic regression models adjusted for maternal and paternal sociodemographic and lifestyle-related characteristics. Compared with nonsmoking mothers, maternal first trimester smoking only was not associated with adverse birth outcomes but was associated with a higher risk of childhood overweight (odds ratio [OR] 1.17 [95% CI 1.02–1.35], P value = 0.030). Children from mothers who continued smoking during pregnancy had higher risks of preterm birth (OR 1.08 [95% CI 1.02–1.15], P value = 0.012), small size for gestational age (OR 2.15 [95% CI 2.07–2.23], P value < 0.001), and childhood overweight (OR 1.42 [95% CI 1.35–1.48], P value < 0.001). Mothers who reduced the number of cigarettes between the first and third trimester, without quitting, still had a higher risk of small size for gestational age. However, the corresponding risk estimates were smaller than for women who continued the same amount of cigarettes throughout pregnancy (OR 1.89 [95% CI 1.52–2.34] instead of OR 2.20 [95% CI 2.02–2.42] when reducing from 5–9 to ≤4 cigarettes/day; OR 2.79 [95% CI 2.39–3.25] and OR 1.93 [95% CI 1.46–2.57] instead of OR 2.95 [95% CI 2.75–3.15] when reducing from ≥10 to 5–9 and ≤4 cigarettes/day, respectively [P values < 0.001]). Reducing the number of cigarettes during pregnancy did not affect the risks of preterm birth and childhood overweight. Among nonsmoking mothers, paternal smoking was associated with childhood overweight (OR 1.21 [95% CI 1.16–1.27], P value < 0.001) but not with adverse birth outcomes. Limitations of this study include the self-report of parental smoking information and the possibility of residual confounding. As this study only included participants from Europe and North America, results need to be carefully interpreted regarding other populations. Conclusions We observed that as compared to nonsmoking during pregnancy, quitting smoking in the first trimester is associated with the same risk of preterm birth and small size for gestational age, but with a higher risk of childhood overweight. Reducing the number of cigarettes, without quitting, has limited beneficial effects. Paternal smoking seems to be associated, independently of maternal smoking, with the risk of childhood overweight. Population strategies should focus on parental smoking prevention before or at the start, rather than during, pregnancy.
  

• 
  1.

  Prinjha S, Ricci-Cabello I, Newhouse N, Farmer A. British South Asian Patients’ Perspectives on the Relevance and Acceptability of Mobile Health Text Messaging to Support Medication Adherence for Type 2 Diabetes: Qualitative Study. JMIR Mhealth Uhealth. 2020;8(4):e15789.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: The prevalence of type 2 diabetes (T2D) is greater in South Asian populations and health outcomes are poorer compared with other ethnic groups. British South Asians are up to six times more likely to have T2D than the general population, to develop the condition at a younger age, and to experience diabetes-related complications. Interventions to support people in managing their condition can potentially reduce debilitating complications. Evidence to support the use of digital devices in T2D management, including mobile phones, has shown positive impacts on glycemic control. There is increasing recognition that health interventions that are culturally adapted to the needs of specific groups are more likely to be relevant and acceptable, but evidence to support the effectiveness of adapted interventions is limited and inconclusive. OBJECTIVE: This formative study aimed to explore the perceptions and views of British South Asian patients with T2D on mobile health SMS text messaging to support medication adherence, aimed at the general UK population. METHODS: Eight exploratory focus groups were conducted in Leicester, the United Kingdom, between September 2017 and March 2018. A diverse sample of 67 adults took part. RESULTS: British South Asian people with T2D who use digital devices, including mobile phones, felt that short messages to support medication adherence would be acceptable and relevant, but they also wanted messages that would support other aspects of self-management too. Participants were particularly interested in content that met their information needs, including information about South Asian foods, commonly used herbs and spices, natural and herbal approaches used in the United Kingdom and in South Asia, and religious fasting. Short messages delivered in English were perceived to be acceptable, often because family members could translate for those unable to read or understand the messages. Suggestions to support patients unable to understand short messages in English included having them available in different formats, and disseminated in face-to-face groups for those who did not use digital devices. CONCLUSIONS: Exploring the views of British South Asian patients about SMS text messaging aimed at the general UK population is important in maximizing the potential of such an intervention. For such a digital system to meet the needs of UK South Asian populations, it may also have to include culturally relevant messages sent to those who opt to receive them. It is equally important to consider how to disseminate message content to patients who do not use digital devices to help reduce health inequalities.

  @article{RN41,
  abstract = {BACKGROUND: The prevalence of type 2 diabetes (T2D) is greater in South Asian populations and health outcomes are poorer compared with other ethnic groups. British South Asians are up to six times more likely to have T2D than the general population, to develop the condition at a younger age, and to experience diabetes-related complications. Interventions to support people in managing their condition can potentially reduce debilitating complications. Evidence to support the use of digital devices in T2D management, including mobile phones, has shown positive impacts on glycemic control. There is increasing recognition that health interventions that are culturally adapted to the needs of specific groups are more likely to be relevant and acceptable, but evidence to support the effectiveness of adapted interventions is limited and inconclusive. OBJECTIVE: This formative study aimed to explore the perceptions and views of British South Asian patients with T2D on mobile health SMS text messaging to support medication adherence, aimed at the general UK population. METHODS: Eight exploratory focus groups were conducted in Leicester, the United Kingdom, between September 2017 and March 2018. A diverse sample of 67 adults took part. RESULTS: British South Asian people with T2D who use digital devices, including mobile phones, felt that short messages to support medication adherence would be acceptable and relevant, but they also wanted messages that would support other aspects of self-management too. Participants were particularly interested in content that met their information needs, including information about South Asian foods, commonly used herbs and spices, natural and herbal approaches used in the United Kingdom and in South Asia, and religious fasting. Short messages delivered in English were perceived to be acceptable, often because family members could translate for those unable to read or understand the messages. Suggestions to support patients unable to understand short messages in English included having them available in different formats, and disseminated in face-to-face groups for those who did not use digital devices. CONCLUSIONS: Exploring the views of British South Asian patients about SMS text messaging aimed at the general UK population is important in maximizing the potential of such an intervention. For such a digital system to meet the needs of UK South Asian populations, it may also have to include culturally relevant messages sent to those who opt to receive them. It is equally important to consider how to disseminate message content to patients who do not use digital devices to help reduce health inequalities.},
  author = {Prinjha, S. and Ricci-Cabello, I. and Newhouse, N. and Farmer, A.},
  journal = {JMIR Mhealth Uhealth},
  keywords = {grapp-caib myown},
  number = 4,
  pages = {e15789},
  title = {British South Asian Patients' Perspectives on the Relevance and Acceptability of Mobile Health Text Messaging to Support Medication Adherence for Type 2 Diabetes: Qualitative Study},
  type = {Journal Article},
  volume = 8,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN41
  %A Prinjha, S.
  %A Ricci-Cabello, I.
  %A Newhouse, N.
  %A Farmer, A.
  %D 2020
  %J JMIR Mhealth Uhealth
  %N 4
  %P e15789
  %R 10.2196/15789
  %T British South Asian Patients' Perspectives on the Relevance and Acceptability of Mobile Health Text Messaging to Support Medication Adherence for Type 2 Diabetes: Qualitative Study
  %V 8
  %X BACKGROUND: The prevalence of type 2 diabetes (T2D) is greater in South Asian populations and health outcomes are poorer compared with other ethnic groups. British South Asians are up to six times more likely to have T2D than the general population, to develop the condition at a younger age, and to experience diabetes-related complications. Interventions to support people in managing their condition can potentially reduce debilitating complications. Evidence to support the use of digital devices in T2D management, including mobile phones, has shown positive impacts on glycemic control. There is increasing recognition that health interventions that are culturally adapted to the needs of specific groups are more likely to be relevant and acceptable, but evidence to support the effectiveness of adapted interventions is limited and inconclusive. OBJECTIVE: This formative study aimed to explore the perceptions and views of British South Asian patients with T2D on mobile health SMS text messaging to support medication adherence, aimed at the general UK population. METHODS: Eight exploratory focus groups were conducted in Leicester, the United Kingdom, between September 2017 and March 2018. A diverse sample of 67 adults took part. RESULTS: British South Asian people with T2D who use digital devices, including mobile phones, felt that short messages to support medication adherence would be acceptable and relevant, but they also wanted messages that would support other aspects of self-management too. Participants were particularly interested in content that met their information needs, including information about South Asian foods, commonly used herbs and spices, natural and herbal approaches used in the United Kingdom and in South Asia, and religious fasting. Short messages delivered in English were perceived to be acceptable, often because family members could translate for those unable to read or understand the messages. Suggestions to support patients unable to understand short messages in English included having them available in different formats, and disseminated in face-to-face groups for those who did not use digital devices. CONCLUSIONS: Exploring the views of British South Asian patients about SMS text messaging aimed at the general UK population is important in maximizing the potential of such an intervention. For such a digital system to meet the needs of UK South Asian populations, it may also have to include culturally relevant messages sent to those who opt to receive them. It is equally important to consider how to disseminate message content to patients who do not use digital devices to help reduce health inequalities.
  

• 
  1.

  Ricci-Cabello I, Vásquez-Mejía A, Canelo-Aybar C, Niño de Guzman E, Pérez-Bracchiglione J, Rabassa M, Rigau D, Solà I, Song Y, Neamtiu L, Parmelli E, Saz-Parkinson Z, Alonso-Coello P. Adherence to breast cancer guidelines is associated with better survival outcomes: a systematic review and meta-analysis of observational studies in EU countries. BMC Health Serv Res [Internet]. 2020;20(1):920. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542898/pdf/12913_2020_Article_5753.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Breast cancer (BC) clinical guidelines offer evidence-based recommendations to improve quality of healthcare for patients with or at risk of BC. Suboptimal adherence to recommendations has the potential to negatively affect population health. However, no study has systematically reviewed the impact of BC guideline adherence -as prognosis factor- on BC healthcare processes and health outcomes. The objectives are to analyse the impact of guideline adherence on health outcomes and on healthcare costs. METHODS: We searched systematic reviews and primary studies in MEDLINE and Embase, conducted in European Union (EU) countries (inception to May 2019). Eligibility assessment, data extraction, and risk of bias assessment were conducted by one author and crosschecked by a second. We used random-effects meta-analyses to examine the impact of guideline adherence on overall survival and disease-free survival, and assessed certainty of evidence using GRADE. RESULTS: We included 21 primary studies. Most were published during the last decade (90%), followed a retrospective cohort design (86%), focused on treatment guideline adherence (95%), and were at low (80%) or moderate (20%) risk of bias. Nineteen studies (95%) examined the impact of guideline adherence on health outcomes, while two (10%) on healthcare cost. Adherence to guidelines was associated with increased overall survival (HR = 0.67, 95%CI 0.59-0.76) and disease-free survival (HR = 0.35, 95%CI 0.15-0.82), representing 138 more survivors (96 more to 178 more) and 336 patients free of recurrence (73 more to 491 more) for every 1000 women receiving adherent CG treatment compared to those receiving non-adherent treatment at 5 years follow-up (moderate certainty). Adherence to treatment guidelines was associated with higher costs, but adherence to follow-up guidelines was associated with lower costs (low certainty). CONCLUSIONS: Our review of EU studies suggests that there is moderate certainty that adherence to BC guidelines is associated with an improved survival. BC guidelines should be rigorously implemented in the clinical setting. TRIAL REGISTRATION: PROSPERO ( CRD42018092884 ).

  @article{RN40,
  abstract = {BACKGROUND: Breast cancer (BC) clinical guidelines offer evidence-based recommendations to improve quality of healthcare for patients with or at risk of BC. Suboptimal adherence to recommendations has the potential to negatively affect population health. However, no study has systematically reviewed the impact of BC guideline adherence -as prognosis factor- on BC healthcare processes and health outcomes. The objectives are to analyse the impact of guideline adherence on health outcomes and on healthcare costs. METHODS: We searched systematic reviews and primary studies in MEDLINE and Embase, conducted in European Union (EU) countries (inception to May 2019). Eligibility assessment, data extraction, and risk of bias assessment were conducted by one author and crosschecked by a second. We used random-effects meta-analyses to examine the impact of guideline adherence on overall survival and disease-free survival, and assessed certainty of evidence using GRADE. RESULTS: We included 21 primary studies. Most were published during the last decade (90%), followed a retrospective cohort design (86%), focused on treatment guideline adherence (95%), and were at low (80%) or moderate (20%) risk of bias. Nineteen studies (95%) examined the impact of guideline adherence on health outcomes, while two (10%) on healthcare cost. Adherence to guidelines was associated with increased overall survival (HR = 0.67, 95%CI 0.59-0.76) and disease-free survival (HR = 0.35, 95%CI 0.15-0.82), representing 138 more survivors (96 more to 178 more) and 336 patients free of recurrence (73 more to 491 more) for every 1000 women receiving adherent CG treatment compared to those receiving non-adherent treatment at 5 years follow-up (moderate certainty). Adherence to treatment guidelines was associated with higher costs, but adherence to follow-up guidelines was associated with lower costs (low certainty). CONCLUSIONS: Our review of EU studies suggests that there is moderate certainty that adherence to BC guidelines is associated with an improved survival. BC guidelines should be rigorously implemented in the clinical setting. TRIAL REGISTRATION: PROSPERO ( CRD42018092884 ).},
  author = {Ricci-Cabello, I. and Vásquez-Mejía, A. and Canelo-Aybar, C. and Niño de Guzman, E. and Pérez-Bracchiglione, J. and Rabassa, M. and Rigau, D. and Solà, I. and Song, Y. and Neamtiu, L. and Parmelli, E. and Saz-Parkinson, Z. and Alonso-Coello, P.},
  journal = {BMC Health Serv Res},
  keywords = {grapp-caib myown},
  number = 1,
  pages = 920,
  title = {Adherence to breast cancer guidelines is associated with better survival outcomes: a systematic review and meta-analysis of observational studies in EU countries},
  type = {Journal Article},
  volume = 20,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN40
  %A Ricci-Cabello, I.
  %A Vásquez-Mejía, A.
  %A Canelo-Aybar, C.
  %A Niño de Guzman, E.
  %A Pérez-Bracchiglione, J.
  %A Rabassa, M.
  %A Rigau, D.
  %A Solà, I.
  %A Song, Y.
  %A Neamtiu, L.
  %A Parmelli, E.
  %A Saz-Parkinson, Z.
  %A Alonso-Coello, P.
  %D 2020
  %J BMC Health Serv Res
  %N 1
  %P 920
  %R 10.1186/s12913-020-05753-x
  %T Adherence to breast cancer guidelines is associated with better survival outcomes: a systematic review and meta-analysis of observational studies in EU countries
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542898/pdf/12913_2020_Article_5753.pdf
  %V 20
  %X BACKGROUND: Breast cancer (BC) clinical guidelines offer evidence-based recommendations to improve quality of healthcare for patients with or at risk of BC. Suboptimal adherence to recommendations has the potential to negatively affect population health. However, no study has systematically reviewed the impact of BC guideline adherence -as prognosis factor- on BC healthcare processes and health outcomes. The objectives are to analyse the impact of guideline adherence on health outcomes and on healthcare costs. METHODS: We searched systematic reviews and primary studies in MEDLINE and Embase, conducted in European Union (EU) countries (inception to May 2019). Eligibility assessment, data extraction, and risk of bias assessment were conducted by one author and crosschecked by a second. We used random-effects meta-analyses to examine the impact of guideline adherence on overall survival and disease-free survival, and assessed certainty of evidence using GRADE. RESULTS: We included 21 primary studies. Most were published during the last decade (90%), followed a retrospective cohort design (86%), focused on treatment guideline adherence (95%), and were at low (80%) or moderate (20%) risk of bias. Nineteen studies (95%) examined the impact of guideline adherence on health outcomes, while two (10%) on healthcare cost. Adherence to guidelines was associated with increased overall survival (HR = 0.67, 95%CI 0.59-0.76) and disease-free survival (HR = 0.35, 95%CI 0.15-0.82), representing 138 more survivors (96 more to 178 more) and 336 patients free of recurrence (73 more to 491 more) for every 1000 women receiving adherent CG treatment compared to those receiving non-adherent treatment at 5 years follow-up (moderate certainty). Adherence to treatment guidelines was associated with higher costs, but adherence to follow-up guidelines was associated with lower costs (low certainty). CONCLUSIONS: Our review of EU studies suggests that there is moderate certainty that adherence to BC guidelines is associated with an improved survival. BC guidelines should be rigorously implemented in the clinical setting. TRIAL REGISTRATION: PROSPERO ( CRD42018092884 ).
  

• 
  1.

  Sarabia-Cobo C, Taltavull-Aparicio J, Miguélez-Chamorro A, Fernández-Rodríguez A, Ortego-Mate C, Fernández-Peña R. Experiences of caregiving and quality of healthcare among caregivers of patients with complex chronic processes: A qualitative study. Applied Nursing Research [Internet]. 2020;56:151344. https://www.sciencedirect.com/science/article/pii/S0897189720300276

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Aim To explore the perceptions of main caregivers regarding caring for chronic complex patients in two different regions of Spain. Background Spain is a country with an ageing population and a high number of people with chronic diseases. It is well known that the role of the caregiver is important to ensure quality of life and appropriate care. Methods Qualitative design using focus groups. Five focus groups, from two different regions, were conducted with 22 caregivers of people with chronic complex diseases to explore their personal experience, examine the quality of care received by the patient and their family and to develop strategies for the improvement of the quality of health care. The focus groups were audio and video recorded. The transcriptions of the focus group sessions were exported to qualitative software analysis MAXQDA 2018.2. The qualitative content analysis was based on different analytical cycles. Results In general terms, caregivers would refer to accepting the care of their family members, but they highlight many negative aspects such as tiredness, lack of help and overload of care. They indicated general satisfaction with the health system but indicated that help was insufficient and that strategies to better address the situations of the complex chronic patient should be improved. The main categories observed were: Conclusions. Complex chronic illnesses are increasingly common at present, generating important consequences on the lives of patients and that of their caregivers. The design of any health strategy for facing the dilemma of chronic illnesses, must necessarily include the vision of the caregivers.

  @article{SARABIACOBO2020151344,
  abstract = {Aim To explore the perceptions of main caregivers regarding caring for chronic complex patients in two different regions of Spain. Background Spain is a country with an ageing population and a high number of people with chronic diseases. It is well known that the role of the caregiver is important to ensure quality of life and appropriate care. Methods Qualitative design using focus groups. Five focus groups, from two different regions, were conducted with 22 caregivers of people with chronic complex diseases to explore their personal experience, examine the quality of care received by the patient and their family and to develop strategies for the improvement of the quality of health care. The focus groups were audio and video recorded. The transcriptions of the focus group sessions were exported to qualitative software analysis MAXQDA 2018.2. The qualitative content analysis was based on different analytical cycles. Results In general terms, caregivers would refer to accepting the care of their family members, but they highlight many negative aspects such as tiredness, lack of help and overload of care. They indicated general satisfaction with the health system but indicated that help was insufficient and that strategies to better address the situations of the complex chronic patient should be improved. The main categories observed were: Conclusions. Complex chronic illnesses are increasingly common at present, generating important consequences on the lives of patients and that of their caregivers. The design of any health strategy for facing the dilemma of chronic illnesses, must necessarily include the vision of the caregivers.},
  author = {Sarabia-Cobo, C. and Taltavull-Aparicio, J.M. and Miguélez-Chamorro, A. and Fernández-Rodríguez, A. and Ortego-Mate, C. and Fernández-Peña, R.},
  journal = {Applied Nursing Research},
  keywords = {grapp-caib},
  pages = 151344,
  title = {Experiences of caregiving and quality of healthcare among caregivers of patients with complex chronic processes: A qualitative study.},
  volume = 56,
  year = 2020
  }
  

  %0 Journal Article
  %1 SARABIACOBO2020151344
  %A Sarabia-Cobo, C.
  %A Taltavull-Aparicio, J.M.
  %A Miguélez-Chamorro, A.
  %A Fernández-Rodríguez, A.
  %A Ortego-Mate, C.
  %A Fernández-Peña, R.
  %D 2020
  %J Applied Nursing Research
  %P 151344
  %R https://doi.org/10.1016/j.apnr.2020.151344
  %T Experiences of caregiving and quality of healthcare among caregivers of patients with complex chronic processes: A qualitative study.
  %U https://www.sciencedirect.com/science/article/pii/S0897189720300276
  %V 56
  %X Aim To explore the perceptions of main caregivers regarding caring for chronic complex patients in two different regions of Spain. Background Spain is a country with an ageing population and a high number of people with chronic diseases. It is well known that the role of the caregiver is important to ensure quality of life and appropriate care. Methods Qualitative design using focus groups. Five focus groups, from two different regions, were conducted with 22 caregivers of people with chronic complex diseases to explore their personal experience, examine the quality of care received by the patient and their family and to develop strategies for the improvement of the quality of health care. The focus groups were audio and video recorded. The transcriptions of the focus group sessions were exported to qualitative software analysis MAXQDA 2018.2. The qualitative content analysis was based on different analytical cycles. Results In general terms, caregivers would refer to accepting the care of their family members, but they highlight many negative aspects such as tiredness, lack of help and overload of care. They indicated general satisfaction with the health system but indicated that help was insufficient and that strategies to better address the situations of the complex chronic patient should be improved. The main categories observed were: Conclusions. Complex chronic illnesses are increasingly common at present, generating important consequences on the lives of patients and that of their caregivers. The design of any health strategy for facing the dilemma of chronic illnesses, must necessarily include the vision of the caregivers.
  

• 
  1.

  Serrano-Ripoll MJ, Meneses-Echavez JF, Ricci-Cabello I, Fraile-Navarro D, Fiol deRoque MA, Pastor-Moreno G, Castro A, Ruiz-Pérez I, Zamanillo Campos R, Gonçalves-Bradley DC. Impact of viral epidemic outbreaks on mental health of healthcare workers: a rapid systematic review and meta-analysis. Journal of Affective Disorders [Internet]. 2020;277:347-5. https://www.sciencedirect.com/science/article/pii/S0165032720326392

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Background: This study aimed at examining the impact of providing healthcare during health emergencies caused by viral epidemic outbreaks on healthcare workers' (HCWs) mental health; to identify factors associated with worse impact, and; to assess the available evidence base regarding interventions to reduce such impact. Method: Rapid systematic review. We searched MEDLINE, Embase, and PsycINFO (inception to August 2020). We pooled data using random-effects meta-analyses to estimate the prevalence of specific mental health problems, and used GRADE to ascertain the certainty of evidence. Results: We included 117 studies. The pooled prevalence was higher for acute stress disorder (40% (95%CI 39 to 41%)), followed by anxiety (30%, (30 to 31%)), burnout (28% (26 to 31%)), depression (24% (24 to 25%)), and post-traumatic stress disorder (13% (13 to 14%)). We identified factors associated with the likelihood of developing those problems, including sociodemographic (younger age and female gender), social (lack of social support, stigmatization), and occupational (working in a high-risk environment, specific occupational roles, and lower levels of specialised training and job experience) factors. Four studies reported interventions for frontline HCW: two educational interventions increased confidence in pandemic self-efficacy and in interpersonal problems solving (very low certainty), whereas one multifaceted intervention improved anxiety, depression, and sleep quality (very low certainty). Limitations: We only searched three databases, and the initial screening was undertaken by a single reviewer. Conclusion: Given the very limited evidence regarding the impact of interventions to tackle mental health problems in HCWs, the risk factors identified represent important targets for future interventions.

  @article{SERRANORIPOLL2020347,
  abstract = {Background: This study aimed at examining the impact of providing healthcare during health emergencies caused by viral epidemic outbreaks on healthcare workers' (HCWs) mental health; to identify factors associated with worse impact, and; to assess the available evidence base regarding interventions to reduce such impact. Method: Rapid systematic review. We searched MEDLINE, Embase, and PsycINFO (inception to August 2020). We pooled data using random-effects meta-analyses to estimate the prevalence of specific mental health problems, and used GRADE to ascertain the certainty of evidence. Results: We included 117 studies. The pooled prevalence was higher for acute stress disorder (40% (95%CI 39 to 41%)), followed by anxiety (30%, (30 to 31%)), burnout (28% (26 to 31%)), depression (24% (24 to 25%)), and post-traumatic stress disorder (13% (13 to 14%)). We identified factors associated with the likelihood of developing those problems, including sociodemographic (younger age and female gender), social (lack of social support, stigmatization), and occupational (working in a high-risk environment, specific occupational roles, and lower levels of specialised training and job experience) factors. Four studies reported interventions for frontline HCW: two educational interventions increased confidence in pandemic self-efficacy and in interpersonal problems solving (very low certainty), whereas one multifaceted intervention improved anxiety, depression, and sleep quality (very low certainty). Limitations: We only searched three databases, and the initial screening was undertaken by a single reviewer. Conclusion: Given the very limited evidence regarding the impact of interventions to tackle mental health problems in HCWs, the risk factors identified represent important targets for future interventions.},
  author = {Serrano-Ripoll, Maria J. and Meneses-Echavez, Jose F. and Ricci-Cabello, Ignacio and Fraile-Navarro, David and Fiol deRoque, Maria A. and Pastor-Moreno, Guadalupe and Castro, Adoración and Ruiz-Pérez, Isabel and Zamanillo Campos, Rocío and Gonçalves-Bradley, Daniela C.},
  journal = {Journal of Affective Disorders},
  keywords = {grapp-caib myown},
  pages = {347-357},
  title = {Impact of viral epidemic outbreaks on mental health of healthcare workers: a rapid systematic review and meta-analysis},
  volume = 277,
  year = 2020
  }
  

  %0 Journal Article
  %1 SERRANORIPOLL2020347
  %A Serrano-Ripoll, Maria J.
  %A Meneses-Echavez, Jose F.
  %A Ricci-Cabello, Ignacio
  %A Fraile-Navarro, David
  %A Fiol deRoque, Maria A.
  %A Pastor-Moreno, Guadalupe
  %A Castro, Adoración
  %A Ruiz-Pérez, Isabel
  %A Zamanillo Campos, Rocío
  %A Gonçalves-Bradley, Daniela C.
  %D 2020
  %J Journal of Affective Disorders
  %P 347-357
  %R https://doi.org/10.1016/j.jad.2020.08.034
  %T Impact of viral epidemic outbreaks on mental health of healthcare workers: a rapid systematic review and meta-analysis
  %U https://www.sciencedirect.com/science/article/pii/S0165032720326392
  %V 277
  %X Background: This study aimed at examining the impact of providing healthcare during health emergencies caused by viral epidemic outbreaks on healthcare workers' (HCWs) mental health; to identify factors associated with worse impact, and; to assess the available evidence base regarding interventions to reduce such impact. Method: Rapid systematic review. We searched MEDLINE, Embase, and PsycINFO (inception to August 2020). We pooled data using random-effects meta-analyses to estimate the prevalence of specific mental health problems, and used GRADE to ascertain the certainty of evidence. Results: We included 117 studies. The pooled prevalence was higher for acute stress disorder (40% (95%CI 39 to 41%)), followed by anxiety (30%, (30 to 31%)), burnout (28% (26 to 31%)), depression (24% (24 to 25%)), and post-traumatic stress disorder (13% (13 to 14%)). We identified factors associated with the likelihood of developing those problems, including sociodemographic (younger age and female gender), social (lack of social support, stigmatization), and occupational (working in a high-risk environment, specific occupational roles, and lower levels of specialised training and job experience) factors. Four studies reported interventions for frontline HCW: two educational interventions increased confidence in pandemic self-efficacy and in interpersonal problems solving (very low certainty), whereas one multifaceted intervention improved anxiety, depression, and sleep quality (very low certainty). Limitations: We only searched three databases, and the initial screening was undertaken by a single reviewer. Conclusion: Given the very limited evidence regarding the impact of interventions to tackle mental health problems in HCWs, the risk factors identified represent important targets for future interventions.
  

• 
  1.

  Ni~no de Guzmán E, Song Y, Alonso-Coello P, Canelo-Aybar C, Neamtiu L, Parmelli E, Pérez-Bracchiglione J, Rabassa M, Rigau D, Parkinson ZS, Solà I, Vásquez-Mejía A, Ricci-Cabello I. Healthcare providers’ adherence to breast cancer guidelines in Europe: a systematic literature review. Breast Cancer Research and Treatment [Internet]. 2020 Jun. 1;181(3):499-518. https://doi.org/10.1007/s10549-020-05657-8

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Clinical guidelines' (CGs) adherence supports high-quality care. However, healthcare providers do not always comply with CGs recommendations. This systematic literature review aims to assess the extent of healthcare providers' adherence to breast cancer CGs in Europe and to identify the factors that impact on healthcare providers' adherence.

  @article{NiñodeGuzmán2020,
  abstract = {Clinical guidelines' (CGs) adherence supports high-quality care. However, healthcare providers do not always comply with CGs recommendations. This systematic literature review aims to assess the extent of healthcare providers' adherence to breast cancer CGs in Europe and to identify the factors that impact on healthcare providers' adherence.},
  author = {Ni~no de Guzmán, Ena and Song, Yang and Alonso-Coello, Pablo and Canelo-Aybar, Carlos and Neamtiu, Luciana and Parmelli, Elena and Pérez-Bracchiglione, Javier and Rabassa, Montserrat and Rigau, David and Parkinson, Zuleika Saz and Solà, Iván and Vásquez-Mejía, Adrián and Ricci-Cabello, Ignacio},
  journal = {Breast Cancer Research and Treatment},
  keywords = {grapp-caib myown},
  month = {jun},
  number = 3,
  pages = {499--518},
  title = {Healthcare providers' adherence to breast cancer guidelines in Europe: a systematic literature review},
  volume = 181,
  year = 2020
  }
  

  %0 Journal Article
  %1 NiñodeGuzmán2020
  %A Ni~no de Guzmán, Ena
  %A Song, Yang
  %A Alonso-Coello, Pablo
  %A Canelo-Aybar, Carlos
  %A Neamtiu, Luciana
  %A Parmelli, Elena
  %A Pérez-Bracchiglione, Javier
  %A Rabassa, Montserrat
  %A Rigau, David
  %A Parkinson, Zuleika Saz
  %A Solà, Iván
  %A Vásquez-Mejía, Adrián
  %A Ricci-Cabello, Ignacio
  %D 2020
  %J Breast Cancer Research and Treatment
  %N 3
  %P 499--518
  %R 10.1007/s10549-020-05657-8
  %T Healthcare providers' adherence to breast cancer guidelines in Europe: a systematic literature review
  %U https://doi.org/10.1007/s10549-020-05657-8
  %V 181
  %X Clinical guidelines' (CGs) adherence supports high-quality care. However, healthcare providers do not always comply with CGs recommendations. This systematic literature review aims to assess the extent of healthcare providers' adherence to breast cancer CGs in Europe and to identify the factors that impact on healthcare providers' adherence.
  

• 
  1.

  Serrano-Ripoll MJ, Ripoll J, Briones-Vozmediano E, Llobera J, Fiol deRoque MA, Ricci-Cabello I. Exploring primary health care professionals’ perceptions about a patient feedback intervention to improve patient safety in Spanish primary health care centres: a qualitative study. Fam Pract [Internet]. 2020;37(6):821-7. https://watermark.silverchair.com/cmaa051.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsUwggLBBgkqhkiG9w0BBwagggKyMIICrgIBADCCAqcGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMrlmN3H5mbo-74U36AgEQgIICeGZfR2aD_EQe0sml2ZkLauhJ8fs5OJjUoC09Em0eEMrUinPcXbeY-xPKV8ry7plrn2jxRao8oca_3IWAPE7BNCA2_Torx19HQrHNANb0fBaaho49PSJnY27tKFN78-LaU5U34nS7w7bGVTCf3fv1RJerjTyJttnFuuJIhUy4B6EB0ahrmYLQLQjDa2xpVcMR4fG1CHkrBhyELPPPC3aQM9S8iVvP1T5TAeHJRCDyXGBEI5xf4KmHec3eVg3MmTtmhJpWrd7yICKuKiYtz_MHeJAO2a6IC6niorr_j_RqTkYfsos-Lc9n_t2x5_pCcouExn6lh4IPEcg76SPHhJ2nzXA3W4Ow3ZmmwzfcOM1MNTqhyJu9gPlO1T4XhMRzaqm9wtd4phQMWUux8IZ606ziK_t3L-v7yO5bVCshZuRG3_4qrBTDM6g2T-z64-7Qi9JQMl1xeuOFyR_MKp7AvDIyhYmMaK74HDHpasfEGtpYlA4TgRm_qHUJL6YWo9BYzzWVhnbYWhw-bL5E_w5wWGGDRd73f_ygYr6u8ZyqNohnnUovKVuffBpTYL6S8LAw6WWedOXezoViHh0lPM1L_PN1yhEbqPCxE7JyEHx5aEh1t9-pHDrSwTJbQUjol9GkRoj8zF4UM7gnvXOkcNyosc5yaMxBq_NCs7PN1jLN4ztGEitY4g6Ds58H94FOpOTHR9q1KO1i_Khk1tOgAsTat6Nw9zqM8CtOtwCaNU05UKhpFyeKTn2xhxeGHxaoPhI6oeRQz-KzCHL8fPybfL4EwdzEgAUGgnjN5LS66Dg7WDET4v9EUp11ZeOqslaS5sw_rEcCf6l1Nvt6D_sS

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Patient feedback interventions are receiving increasing attention given their potential to improve health care provision. However, primary health care (PHC) professionals' acceptability and perceived utility of this type of interventions remain largely unexplored. OBJECTIVES: The aim of this study was to explore PHC professionals' perceptions, opinions and suggestions about a patient feedback intervention currently being designed to improve patient safety in Spanish PHC centres. METHODS: We conducted an exploratory qualitative study with 43 PHC professionals. Information was obtained from three semi-structured interviews and four focus groups. All data were audio-recorded, transcribed and analyzed using content analysis by three analysts. RESULTS: The patient feedback intervention was acceptable to health care professionals, who perceived it as a useful strategy to improve health care processes and activate patients. A number of factors potentially limiting the acceptability and perceived utility of the intervention were identified (low patient safety culture, low patient-centred care orientation and limited credibility of patient feedback data). Recommendations for designing and implementing the proposed intervention in the Spanish PHC centres were identified in relation to the following areas: 'collection and analysis of feedback data'; 'feedback display'; 'feedback delivery' and; 'implementation of safety improvement initiatives'. CONCLUSIONS: Although the proposed intervention was generally perceived as useful and acceptable, our study identified a number of tensions about the practical aspects of using the patient-reported data and the credibility of the data and what actions would arise from its use. The intervention has been adapted to address these tensions before its formal evaluation in a randomized clinical trial.

  @article{RN34,
  abstract = {BACKGROUND: Patient feedback interventions are receiving increasing attention given their potential to improve health care provision. However, primary health care (PHC) professionals' acceptability and perceived utility of this type of interventions remain largely unexplored. OBJECTIVES: The aim of this study was to explore PHC professionals' perceptions, opinions and suggestions about a patient feedback intervention currently being designed to improve patient safety in Spanish PHC centres. METHODS: We conducted an exploratory qualitative study with 43 PHC professionals. Information was obtained from three semi-structured interviews and four focus groups. All data were audio-recorded, transcribed and analyzed using content analysis by three analysts. RESULTS: The patient feedback intervention was acceptable to health care professionals, who perceived it as a useful strategy to improve health care processes and activate patients. A number of factors potentially limiting the acceptability and perceived utility of the intervention were identified (low patient safety culture, low patient-centred care orientation and limited credibility of patient feedback data). Recommendations for designing and implementing the proposed intervention in the Spanish PHC centres were identified in relation to the following areas: 'collection and analysis of feedback data'; 'feedback display'; 'feedback delivery' and; 'implementation of safety improvement initiatives'. CONCLUSIONS: Although the proposed intervention was generally perceived as useful and acceptable, our study identified a number of tensions about the practical aspects of using the patient-reported data and the credibility of the data and what actions would arise from its use. The intervention has been adapted to address these tensions before its formal evaluation in a randomized clinical trial.},
  author = {Serrano-Ripoll, M. J. and Ripoll, J. and Briones-Vozmediano, E. and Llobera, J. and Fiol deRoque, M. A. and Ricci-Cabello, I.},
  journal = {Fam Pract},
  keywords = {grapp-caib myown},
  number = 6,
  pages = {821-827},
  title = {Exploring primary health care professionals' perceptions about a patient feedback intervention to improve patient safety in Spanish primary health care centres: a qualitative study},
  type = {Journal Article},
  volume = 37,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN34
  %A Serrano-Ripoll, M. J.
  %A Ripoll, J.
  %A Briones-Vozmediano, E.
  %A Llobera, J.
  %A Fiol deRoque, M. A.
  %A Ricci-Cabello, I.
  %D 2020
  %J Fam Pract
  %N 6
  %P 821-827
  %R 10.1093/fampra/cmaa051
  %T Exploring primary health care professionals' perceptions about a patient feedback intervention to improve patient safety in Spanish primary health care centres: a qualitative study
  %U https://watermark.silverchair.com/cmaa051.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsUwggLBBgkqhkiG9w0BBwagggKyMIICrgIBADCCAqcGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMrlmN3H5mbo-74U36AgEQgIICeGZfR2aD_EQe0sml2ZkLauhJ8fs5OJjUoC09Em0eEMrUinPcXbeY-xPKV8ry7plrn2jxRao8oca_3IWAPE7BNCA2_Torx19HQrHNANb0fBaaho49PSJnY27tKFN78-LaU5U34nS7w7bGVTCf3fv1RJerjTyJttnFuuJIhUy4B6EB0ahrmYLQLQjDa2xpVcMR4fG1CHkrBhyELPPPC3aQM9S8iVvP1T5TAeHJRCDyXGBEI5xf4KmHec3eVg3MmTtmhJpWrd7yICKuKiYtz_MHeJAO2a6IC6niorr_j_RqTkYfsos-Lc9n_t2x5_pCcouExn6lh4IPEcg76SPHhJ2nzXA3W4Ow3ZmmwzfcOM1MNTqhyJu9gPlO1T4XhMRzaqm9wtd4phQMWUux8IZ606ziK_t3L-v7yO5bVCshZuRG3_4qrBTDM6g2T-z64-7Qi9JQMl1xeuOFyR_MKp7AvDIyhYmMaK74HDHpasfEGtpYlA4TgRm_qHUJL6YWo9BYzzWVhnbYWhw-bL5E_w5wWGGDRd73f_ygYr6u8ZyqNohnnUovKVuffBpTYL6S8LAw6WWedOXezoViHh0lPM1L_PN1yhEbqPCxE7JyEHx5aEh1t9-pHDrSwTJbQUjol9GkRoj8zF4UM7gnvXOkcNyosc5yaMxBq_NCs7PN1jLN4ztGEitY4g6Ds58H94FOpOTHR9q1KO1i_Khk1tOgAsTat6Nw9zqM8CtOtwCaNU05UKhpFyeKTn2xhxeGHxaoPhI6oeRQz-KzCHL8fPybfL4EwdzEgAUGgnjN5LS66Dg7WDET4v9EUp11ZeOqslaS5sw_rEcCf6l1Nvt6D_sS
  %V 37
  %X BACKGROUND: Patient feedback interventions are receiving increasing attention given their potential to improve health care provision. However, primary health care (PHC) professionals' acceptability and perceived utility of this type of interventions remain largely unexplored. OBJECTIVES: The aim of this study was to explore PHC professionals' perceptions, opinions and suggestions about a patient feedback intervention currently being designed to improve patient safety in Spanish PHC centres. METHODS: We conducted an exploratory qualitative study with 43 PHC professionals. Information was obtained from three semi-structured interviews and four focus groups. All data were audio-recorded, transcribed and analyzed using content analysis by three analysts. RESULTS: The patient feedback intervention was acceptable to health care professionals, who perceived it as a useful strategy to improve health care processes and activate patients. A number of factors potentially limiting the acceptability and perceived utility of the intervention were identified (low patient safety culture, low patient-centred care orientation and limited credibility of patient feedback data). Recommendations for designing and implementing the proposed intervention in the Spanish PHC centres were identified in relation to the following areas: 'collection and analysis of feedback data'; 'feedback display'; 'feedback delivery' and; 'implementation of safety improvement initiatives'. CONCLUSIONS: Although the proposed intervention was generally perceived as useful and acceptable, our study identified a number of tensions about the practical aspects of using the patient-reported data and the credibility of the data and what actions would arise from its use. The intervention has been adapted to address these tensions before its formal evaluation in a randomized clinical trial.
  

• 
  1.

  Thyssen JP, Ahluwalia TS, Paternoster L, Ballardini N, Bergström A, Melén E, Chawes BL, Stokholm J, Hourihane JO, O’Sullivan DM, Bager P, Melbye M, Bustamante M, Torrent M, Esplugues A, Duijts L, Hu C, Elbert NJ, Pasmans S, Nijsten TEC, von Berg A, Standl M, Schikowski T, Herberth G, Heinrich J, Lee YA, Marenholz I, Lau S, Curtin JA, Simpson A, Custovic A, Pennell CE, Wang CA, Holt PG, Bisgaard H, Bønnelykke K. Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis. Allergy [Internet]. 2020;75(6):1481-5. https://onlinelibrary.wiley.com/doi/10.1111/all.14162

  URLBibTeXEndNoteDOIBibSonomy

  @article{RN57,
  author = {Thyssen, J. P. and Ahluwalia, T. S. and Paternoster, L. and Ballardini, N. and Bergström, A. and Melén, E. and Chawes, B. L. and Stokholm, J. and Hourihane, J. O. and O'Sullivan, D. M. and Bager, P. and Melbye, M. and Bustamante, M. and Torrent, M. and Esplugues, A. and Duijts, L. and Hu, C. and Elbert, N. J. and Pasmans, Sgma and Nijsten, T. E. C. and von Berg, A. and Standl, M. and Schikowski, T. and Herberth, G. and Heinrich, J. and Lee, Y. A. and Marenholz, I. and Lau, S. and Curtin, J. A. and Simpson, A. and Custovic, A. and Pennell, C. E. and Wang, C. A. and Holt, P. G. and Bisgaard, H. and Bønnelykke, K.},
  journal = {Allergy},
  keywords = {grapp-caib},
  number = 6,
  pages = {1481-1485},
  title = {Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis},
  type = {Journal Article},
  volume = 75,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN57
  %A Thyssen, J. P.
  %A Ahluwalia, T. S.
  %A Paternoster, L.
  %A Ballardini, N.
  %A Bergström, A.
  %A Melén, E.
  %A Chawes, B. L.
  %A Stokholm, J.
  %A Hourihane, J. O.
  %A O'Sullivan, D. M.
  %A Bager, P.
  %A Melbye, M.
  %A Bustamante, M.
  %A Torrent, M.
  %A Esplugues, A.
  %A Duijts, L.
  %A Hu, C.
  %A Elbert, N. J.
  %A Pasmans, Sgma
  %A Nijsten, T. E. C.
  %A von Berg, A.
  %A Standl, M.
  %A Schikowski, T.
  %A Herberth, G.
  %A Heinrich, J.
  %A Lee, Y. A.
  %A Marenholz, I.
  %A Lau, S.
  %A Curtin, J. A.
  %A Simpson, A.
  %A Custovic, A.
  %A Pennell, C. E.
  %A Wang, C. A.
  %A Holt, P. G.
  %A Bisgaard, H.
  %A Bønnelykke, K.
  %D 2020
  %J Allergy
  %N 6
  %P 1481-1485
  %R 10.1111/all.14162
  %T Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis
  %U https://onlinelibrary.wiley.com/doi/10.1111/all.14162
  %V 75
  

• 
  1.

  Unda Villafuerte F, Llobera Cànaves J, Lorente Montalvo P, Moreno Sancho ML, Oliver Oliver B, Bassante Flores P, Estela Mantolan A, Pou Bordoy J, Rodríguez Ruiz T, Requena Hernández A, Leiva A, Torrent Quetglas M, Coll Benejam JM, D’Agosto Forteza P, Rigo Carratalà F. Effectiveness of a multifactorial intervention, consisting of self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise, in patients with uncontrolled hypertension taking 2 or more antihypertensive drugs: The MEDICHY study. Medicine (Baltimore) [Internet]. 2020;99(17):e19769. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220514/pdf/medi-99-e19769.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: High blood pressure is the leading modifiable risk factor for cardiovascular disease, and is associated with high morbidity and mortality and with significant health care costs for individuals and society. However, fewer than half of the patients with hypertension receiving pharmacological treatment have adequate blood pressure control. The main reasons for this are therapeutic inertia, lack of adherence to treatment, and unhealthy lifestyle (i.e., excess dietary fat and salt, sedentary lifestyle, and overweight). Cardiovascular risk and mortality are greater in hypertensive patients who are receiving treatment but have suboptimal control of blood pressure. METHODS/DESIGN: This is a multicentre, parallel, 2-arm, single-blind (outcome assessor), controled, cluster-randomized clinical trial. General practitioners and nurses will be randomly allocated to the intervention group (self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise) or the control group (regular clinical practice). A total of 424 patients in primary care centers who use 2 or more antihypertensive drugs and blood pressure of at least 130/80 during 24-hambulatory blood pressure monitoring will be recruited. The primary outcome is systolic blood pressure at 12 months. The secondary outcomes are blood pressure control (<140/90 mm Hg); quality of life (EuroQol 5D); direct health care costs; adherence to use of antihypertensive medication; and cardiovascular risk (REGICOR and SCORE scales). DISCUSSION: This trial will be conducted in the primary care setting and will evaluate the impact of a multifactorial intervention consisting of self-management of blood pressure, antihypertensive medications, and lifestyle modifications (hypocaloric and low sodium diet and physical exercise).

  @article{RN48,
  abstract = {INTRODUCTION: High blood pressure is the leading modifiable risk factor for cardiovascular disease, and is associated with high morbidity and mortality and with significant health care costs for individuals and society. However, fewer than half of the patients with hypertension receiving pharmacological treatment have adequate blood pressure control. The main reasons for this are therapeutic inertia, lack of adherence to treatment, and unhealthy lifestyle (i.e., excess dietary fat and salt, sedentary lifestyle, and overweight). Cardiovascular risk and mortality are greater in hypertensive patients who are receiving treatment but have suboptimal control of blood pressure. METHODS/DESIGN: This is a multicentre, parallel, 2-arm, single-blind (outcome assessor), controled, cluster-randomized clinical trial. General practitioners and nurses will be randomly allocated to the intervention group (self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise) or the control group (regular clinical practice). A total of 424 patients in primary care centers who use 2 or more antihypertensive drugs and blood pressure of at least 130/80 during 24-hambulatory blood pressure monitoring will be recruited. The primary outcome is systolic blood pressure at 12 months. The secondary outcomes are blood pressure control (<140/90 mm Hg); quality of life (EuroQol 5D); direct health care costs; adherence to use of antihypertensive medication; and cardiovascular risk (REGICOR and SCORE scales). DISCUSSION: This trial will be conducted in the primary care setting and will evaluate the impact of a multifactorial intervention consisting of self-management of blood pressure, antihypertensive medications, and lifestyle modifications (hypocaloric and low sodium diet and physical exercise).},
  author = {Unda Villafuerte, F. and Llobera Cànaves, J. and Lorente Montalvo, P. and Moreno Sancho, M. L. and Oliver Oliver, B. and Bassante Flores, P. and Estela Mantolan, A. and Pou Bordoy, J. and Rodríguez Ruiz, T. and Requena Hernández, A. and Leiva, A. and Torrent Quetglas, M. and Coll Benejam, J. M. and D'Agosto Forteza, P. and Rigo Carratalà, F.},
  journal = {Medicine (Baltimore)},
  keywords = {grapp-caib},
  number = 17,
  pages = {e19769},
  title = {Effectiveness of a multifactorial intervention, consisting of self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise, in patients with uncontrolled hypertension taking 2 or more antihypertensive drugs: The MEDICHY study},
  type = {Journal Article},
  volume = 99,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN48
  %A Unda Villafuerte, F.
  %A Llobera Cànaves, J.
  %A Lorente Montalvo, P.
  %A Moreno Sancho, M. L.
  %A Oliver Oliver, B.
  %A Bassante Flores, P.
  %A Estela Mantolan, A.
  %A Pou Bordoy, J.
  %A Rodríguez Ruiz, T.
  %A Requena Hernández, A.
  %A Leiva, A.
  %A Torrent Quetglas, M.
  %A Coll Benejam, J. M.
  %A D'Agosto Forteza, P.
  %A Rigo Carratalà, F.
  %D 2020
  %J Medicine (Baltimore)
  %N 17
  %P e19769
  %R 10.1097/md.0000000000019769
  %T Effectiveness of a multifactorial intervention, consisting of self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise, in patients with uncontrolled hypertension taking 2 or more antihypertensive drugs: The MEDICHY study
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220514/pdf/medi-99-e19769.pdf
  %V 99
  %X INTRODUCTION: High blood pressure is the leading modifiable risk factor for cardiovascular disease, and is associated with high morbidity and mortality and with significant health care costs for individuals and society. However, fewer than half of the patients with hypertension receiving pharmacological treatment have adequate blood pressure control. The main reasons for this are therapeutic inertia, lack of adherence to treatment, and unhealthy lifestyle (i.e., excess dietary fat and salt, sedentary lifestyle, and overweight). Cardiovascular risk and mortality are greater in hypertensive patients who are receiving treatment but have suboptimal control of blood pressure. METHODS/DESIGN: This is a multicentre, parallel, 2-arm, single-blind (outcome assessor), controled, cluster-randomized clinical trial. General practitioners and nurses will be randomly allocated to the intervention group (self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise) or the control group (regular clinical practice). A total of 424 patients in primary care centers who use 2 or more antihypertensive drugs and blood pressure of at least 130/80 during 24-hambulatory blood pressure monitoring will be recruited. The primary outcome is systolic blood pressure at 12 months. The secondary outcomes are blood pressure control (<140/90 mm Hg); quality of life (EuroQol 5D); direct health care costs; adherence to use of antihypertensive medication; and cardiovascular risk (REGICOR and SCORE scales). DISCUSSION: This trial will be conducted in the primary care setting and will evaluate the impact of a multifactorial intervention consisting of self-management of blood pressure, antihypertensive medications, and lifestyle modifications (hypocaloric and low sodium diet and physical exercise).
  

• 
  1.

  Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C, Stergiakouli E, Heiskala A, Horikoshi M, Fedko IO, Vilor-Tejedor N, Cousminer DL, Standl M, Wang CA, Viikari J, Geller F, Íñiguez C, Pitkänen N, Chesi A, Bacelis J, Yengo L, Torrent M, Ntalla I, Helgeland Øyvind, Selzam S, Vonk JM, Zafarmand MH, Heude B, Farooqi IS, Alyass A, Beaumont RN, Have CT, Rzehak P, Bilbao JR, Schnurr TM, Barroso I, Bønnelykke K, Beilin LJ, Carstensen L, Charles M-A, Chawes B, Clément K, Closa-Monasterolo R, Custovic A, Eriksson JG, Escribano J, Groen-Blokhuis M, Grote V, Gruszfeld D, Hakonarson H, Hansen T, Hattersley AT, Hollensted M, Hottenga J-J, Hyppönen E, Johansson S, Joro R, Kähönen M, Karhunen V, Kiess W, Knight BA, Koletzko B, Kühnapfel A, Landgraf K, Langhendries J-P, Lehtimäki T, Leinonen JT, Li A, Lindi V, Lowry E, Bustamante M, Medina-Gomez C, Melbye M, Michaelsen KF, Morgen CS, Mori TA, Nielsen TRH, Niinikoski H, Oldehinkel AJ, Pahkala K, Panoutsopoulou K, Pedersen O, Pennell CE, Power C, Reijneveld SA, Rivadeneira F, Simpson A, Sly PD, Stokholm J, Teo KK, Thiering E, Timpson NJ, Uitterlinden AG, van Beijsterveldt CEM, van Schaik BDC, Vaudel M, Verduci E, Vinding RK, Vogel M, Zeggini E, Sebert S, Lind MV, Brown CD, Santa-Marina L, Reischl E, Frithioff-Bøjsøe C, Meyre D, Wheeler E, Ong K, Nohr EA, Vrijkotte TGM, Koppelman GH, Plomin R, Njølstad PR, Dedoussis GD, Froguel P, Sørensen TIA, Jacobsson B, Freathy RM, Zemel BS, Raitakari O, Vrijheid M, Feenstra B, Lyytikäinen L-P, Snieder H, Kirsten H, Holt PG, Heinrich J, Widén E, Sunyer J, Boomsma DI, Järvelin M-R, Körner A, Davey Smith G, Holm J-C, Atalay M, Murray C, Bisgaard H, McCarthy MI, Consortium EGG, Jaddoe VWV, Grant SFA, Felix JF. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLOS Genetics [Internet]. Public Library of Science; 2020 Oct.;16(10):1-26. https://doi.org/10.1371/journal.pgen.1008718

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.

  @article{10.1371/journal.pgen.1008718,
  abstract = {The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.},
  author = {Vogelezang, Suzanne and Bradfield, Jonathan P. and Ahluwalia, Tarunveer S. and Curtin, John A. and Lakka, Timo A. and Grarup, Niels and Scholz, Markus and van der Most, Peter J. and Monnereau, Claire and Stergiakouli, Evie and Heiskala, Anni and Horikoshi, Momoko and Fedko, Iryna O. and Vilor-Tejedor, Natalia and Cousminer, Diana L. and Standl, Marie and Wang, Carol A. and Viikari, Jorma and Geller, Frank and Íñiguez, Carmen and Pitkänen, Niina and Chesi, Alessandra and Bacelis, Jonas and Yengo, Loic and Torrent, Maties and Ntalla, Ioanna and Helgeland, Øyvind and Selzam, Saskia and Vonk, Judith M. and Zafarmand, Mohammed H. and Heude, Barbara and Farooqi, Ismaa Sadaf and Alyass, Akram and Beaumont, Robin N. and Have, Christian T. and Rzehak, Peter and Bilbao, Jose Ramon and Schnurr, Theresia M. and Barroso, Inês and Bønnelykke, Klaus and Beilin, Lawrence J. and Carstensen, Lisbeth and Charles, Marie-Aline and Chawes, Bo and Clément, Karine and Closa-Monasterolo, Ricardo and Custovic, Adnan and Eriksson, Johan G. and Escribano, Joaquin and Groen-Blokhuis, Maria and Grote, Veit and Gruszfeld, Dariusz and Hakonarson, Hakon and Hansen, Torben and Hattersley, Andrew T. and Hollensted, Mette and Hottenga, Jouke-Jan and Hyppönen, Elina and Johansson, Stefan and Joro, Raimo and Kähönen, Mika and Karhunen, Ville and Kiess, Wieland and Knight, Bridget A. and Koletzko, Berthold and Kühnapfel, Andreas and Landgraf, Kathrin and Langhendries, Jean-Paul and Lehtimäki, Terho and Leinonen, Jaakko T. and Li, Aihuali and Lindi, Virpi and Lowry, Estelle and Bustamante, Mariona and Medina-Gomez, Carolina and Melbye, Mads and Michaelsen, Kim F. and Morgen, Camilla S. and Mori, Trevor A. and Nielsen, Tenna R. H. and Niinikoski, Harri and Oldehinkel, Albertine J. and Pahkala, Katja and Panoutsopoulou, Kalliope and Pedersen, Oluf and Pennell, Craig E. and Power, Christine and Reijneveld, Sijmen A. and Rivadeneira, Fernando and Simpson, Angela and Sly, Peter D. and Stokholm, Jakob and Teo, Kook K. and Thiering, Elisabeth and Timpson, Nicholas J. and Uitterlinden, André G. and van Beijsterveldt, Catharina E. M. and van Schaik, Barbera D. C. and Vaudel, Marc and Verduci, Elvira and Vinding, Rebecca K. and Vogel, Mandy and Zeggini, Eleftheria and Sebert, Sylvain and Lind, Mads V. and Brown, Christopher D. and Santa-Marina, Loreto and Reischl, Eva and Frithioff-Bøjsøe, Christine and Meyre, David and Wheeler, Eleanor and Ong, Ken and Nohr, Ellen A. and Vrijkotte, Tanja G. M. and Koppelman, Gerard H. and Plomin, Robert and Njølstad, Pål R. and Dedoussis, George D. and Froguel, Philippe and Sørensen, Thorkild I. A. and Jacobsson, Bo and Freathy, Rachel M. and Zemel, Babette S. and Raitakari, Olli and Vrijheid, Martine and Feenstra, Bjarke and Lyytikäinen, Leo-Pekka and Snieder, Harold and Kirsten, Holger and Holt, Patrick G. and Heinrich, Joachim and Widén, Elisabeth and Sunyer, Jordi and Boomsma, Dorret I. and Järvelin, Marjo-Riitta and Körner, Antje and Davey Smith, George and Holm, Jens-Christian and Atalay, Mustafa and Murray, Clare and Bisgaard, Hans and McCarthy, Mark I. and Consortium, Early Growth Genetics and Jaddoe, Vincent W. V. and Grant, Struan F. A. and Felix, Janine F.},
  journal = {PLOS Genetics},
  keywords = {grapp-caib},
  month = 10,
  number = 10,
  pages = {1-26},
  publisher = {Public Library of Science},
  title = {Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits},
  volume = 16,
  year = 2020
  }
  

  %0 Journal Article
  %1 10.1371/journal.pgen.1008718
  %A Vogelezang, Suzanne
  %A Bradfield, Jonathan P.
  %A Ahluwalia, Tarunveer S.
  %A Curtin, John A.
  %A Lakka, Timo A.
  %A Grarup, Niels
  %A Scholz, Markus
  %A van der Most, Peter J.
  %A Monnereau, Claire
  %A Stergiakouli, Evie
  %A Heiskala, Anni
  %A Horikoshi, Momoko
  %A Fedko, Iryna O.
  %A Vilor-Tejedor, Natalia
  %A Cousminer, Diana L.
  %A Standl, Marie
  %A Wang, Carol A.
  %A Viikari, Jorma
  %A Geller, Frank
  %A Íñiguez, Carmen
  %A Pitkänen, Niina
  %A Chesi, Alessandra
  %A Bacelis, Jonas
  %A Yengo, Loic
  %A Torrent, Maties
  %A Ntalla, Ioanna
  %A Helgeland, Øyvind
  %A Selzam, Saskia
  %A Vonk, Judith M.
  %A Zafarmand, Mohammed H.
  %A Heude, Barbara
  %A Farooqi, Ismaa Sadaf
  %A Alyass, Akram
  %A Beaumont, Robin N.
  %A Have, Christian T.
  %A Rzehak, Peter
  %A Bilbao, Jose Ramon
  %A Schnurr, Theresia M.
  %A Barroso, Inês
  %A Bønnelykke, Klaus
  %A Beilin, Lawrence J.
  %A Carstensen, Lisbeth
  %A Charles, Marie-Aline
  %A Chawes, Bo
  %A Clément, Karine
  %A Closa-Monasterolo, Ricardo
  %A Custovic, Adnan
  %A Eriksson, Johan G.
  %A Escribano, Joaquin
  %A Groen-Blokhuis, Maria
  %A Grote, Veit
  %A Gruszfeld, Dariusz
  %A Hakonarson, Hakon
  %A Hansen, Torben
  %A Hattersley, Andrew T.
  %A Hollensted, Mette
  %A Hottenga, Jouke-Jan
  %A Hyppönen, Elina
  %A Johansson, Stefan
  %A Joro, Raimo
  %A Kähönen, Mika
  %A Karhunen, Ville
  %A Kiess, Wieland
  %A Knight, Bridget A.
  %A Koletzko, Berthold
  %A Kühnapfel, Andreas
  %A Landgraf, Kathrin
  %A Langhendries, Jean-Paul
  %A Lehtimäki, Terho
  %A Leinonen, Jaakko T.
  %A Li, Aihuali
  %A Lindi, Virpi
  %A Lowry, Estelle
  %A Bustamante, Mariona
  %A Medina-Gomez, Carolina
  %A Melbye, Mads
  %A Michaelsen, Kim F.
  %A Morgen, Camilla S.
  %A Mori, Trevor A.
  %A Nielsen, Tenna R. H.
  %A Niinikoski, Harri
  %A Oldehinkel, Albertine J.
  %A Pahkala, Katja
  %A Panoutsopoulou, Kalliope
  %A Pedersen, Oluf
  %A Pennell, Craig E.
  %A Power, Christine
  %A Reijneveld, Sijmen A.
  %A Rivadeneira, Fernando
  %A Simpson, Angela
  %A Sly, Peter D.
  %A Stokholm, Jakob
  %A Teo, Kook K.
  %A Thiering, Elisabeth
  %A Timpson, Nicholas J.
  %A Uitterlinden, André G.
  %A van Beijsterveldt, Catharina E. M.
  %A van Schaik, Barbera D. C.
  %A Vaudel, Marc
  %A Verduci, Elvira
  %A Vinding, Rebecca K.
  %A Vogel, Mandy
  %A Zeggini, Eleftheria
  %A Sebert, Sylvain
  %A Lind, Mads V.
  %A Brown, Christopher D.
  %A Santa-Marina, Loreto
  %A Reischl, Eva
  %A Frithioff-Bøjsøe, Christine
  %A Meyre, David
  %A Wheeler, Eleanor
  %A Ong, Ken
  %A Nohr, Ellen A.
  %A Vrijkotte, Tanja G. M.
  %A Koppelman, Gerard H.
  %A Plomin, Robert
  %A Njølstad, Pål R.
  %A Dedoussis, George D.
  %A Froguel, Philippe
  %A Sørensen, Thorkild I. A.
  %A Jacobsson, Bo
  %A Freathy, Rachel M.
  %A Zemel, Babette S.
  %A Raitakari, Olli
  %A Vrijheid, Martine
  %A Feenstra, Bjarke
  %A Lyytikäinen, Leo-Pekka
  %A Snieder, Harold
  %A Kirsten, Holger
  %A Holt, Patrick G.
  %A Heinrich, Joachim
  %A Widén, Elisabeth
  %A Sunyer, Jordi
  %A Boomsma, Dorret I.
  %A Järvelin, Marjo-Riitta
  %A Körner, Antje
  %A Davey Smith, George
  %A Holm, Jens-Christian
  %A Atalay, Mustafa
  %A Murray, Clare
  %A Bisgaard, Hans
  %A McCarthy, Mark I.
  %A Consortium, Early Growth Genetics
  %A Jaddoe, Vincent W. V.
  %A Grant, Struan F. A.
  %A Felix, Janine F.
  %D 2020
  %I Public Library of Science
  %J PLOS Genetics
  %N 10
  %P 1-26
  %R 10.1371/journal.pgen.1008718
  %T Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
  %U https://doi.org/10.1371/journal.pgen.1008718
  %V 16
  %X The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
  

• 
  1.

  Yañez AM, Bennasar-Veny M, Leiva A, García-Toro M. Implications of personality and parental education on healthy lifestyles among adolescents. Sci Rep [Internet]. 2020;10(1):7911. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220907/pdf/41598_2020_Article_64850.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Several studies have shown an association between personality and health status. The aim of this study was to evaluate the association between personality traits, parental education and health-related lifestyles in a cohort of Spanish adolescents. This is a longitudinal study with a source population of 1,123 third-year students (aged 14-15) in secondary schools in Spain. At the baseline evaluation sociodemographic variables, parental education and personality (Big Five Questionnaire for Children) were collected. At 18 months of follow-up health related lifestyles, including adherence to a healthy diet (KidMed index), tobacco and alcohol consumption, physical exercise, sleep problems and recreative screen and social network time were collected. A total of 824 adolescents (73.4%) completed the 18 months assessment and 695 (84.3%) presented valid data. Higher conscientiousness was associated to a lower risk for non-adherence to Mediterranean diet (OR = 0.7, 95% CIs=0.5-0.9), tobacco (OR = 0.5, 95% CIs=0.3-0.7) and alcohol consumption (OR = 0.6, 95% CIs=0.5-0.8), excessive use of screens (OR = 0.7, 95% CIs=0.5-0.9) and social network sites (OR = 0.7, 95% CIs=0.5-0.8). Higher levels of extraversion was significantly related to a lower risk of physical inactivity (OR = 0.7, 95% CIs=0.6-0.9), but they are at a higher risk of low adherence to Mediterranean diet (OR = 1.3, 95% CIs=1.0-1.7), tobacco (OR = 2.7, 95% CIs=1.7-4.3) and alcohol consumption (OR = 1.9, 95% CIs=1.5-2.4) and excessive use of social network sites (OR = 1.6, 95% CIs=1.3-1.9). High levels of emotional instability were associated with tobacco consumption (OR = 1.5, 95% CIs=1.0-2.2) and sleep problems (OR = 2.0, 95% CIs=1.5-2.7). Finally, we found an association with lower parental education and adolescents' low adherence to Mediterranean diet (OR = 1.6, 95% CIs=1.0-2.4) and sleep problems (OR = 1.8, 95% CIs=1.0-3.0). Cluster analysis of health-related behaviours indicated the presence of two different clusters (unhealthy and healthy adolescents) that were associated with personality traits. Conscientiousness, extraversion, emotional instability and parental education are independent factors associated with the acquisition of adolescent healthy lifestyles.

  @article{RN54,
  abstract = {Several studies have shown an association between personality and health status. The aim of this study was to evaluate the association between personality traits, parental education and health-related lifestyles in a cohort of Spanish adolescents. This is a longitudinal study with a source population of 1,123 third-year students (aged 14-15) in secondary schools in Spain. At the baseline evaluation sociodemographic variables, parental education and personality (Big Five Questionnaire for Children) were collected. At 18 months of follow-up health related lifestyles, including adherence to a healthy diet (KidMed index), tobacco and alcohol consumption, physical exercise, sleep problems and recreative screen and social network time were collected. A total of 824 adolescents (73.4%) completed the 18 months assessment and 695 (84.3%) presented valid data. Higher conscientiousness was associated to a lower risk for non-adherence to Mediterranean diet (OR = 0.7, 95% CIs=0.5-0.9), tobacco (OR = 0.5, 95% CIs=0.3-0.7) and alcohol consumption (OR = 0.6, 95% CIs=0.5-0.8), excessive use of screens (OR = 0.7, 95% CIs=0.5-0.9) and social network sites (OR = 0.7, 95% CIs=0.5-0.8). Higher levels of extraversion was significantly related to a lower risk of physical inactivity (OR = 0.7, 95% CIs=0.6-0.9), but they are at a higher risk of low adherence to Mediterranean diet (OR = 1.3, 95% CIs=1.0-1.7), tobacco (OR = 2.7, 95% CIs=1.7-4.3) and alcohol consumption (OR = 1.9, 95% CIs=1.5-2.4) and excessive use of social network sites (OR = 1.6, 95% CIs=1.3-1.9). High levels of emotional instability were associated with tobacco consumption (OR = 1.5, 95% CIs=1.0-2.2) and sleep problems (OR = 2.0, 95% CIs=1.5-2.7). Finally, we found an association with lower parental education and adolescents' low adherence to Mediterranean diet (OR = 1.6, 95% CIs=1.0-2.4) and sleep problems (OR = 1.8, 95% CIs=1.0-3.0). Cluster analysis of health-related behaviours indicated the presence of two different clusters (unhealthy and healthy adolescents) that were associated with personality traits. Conscientiousness, extraversion, emotional instability and parental education are independent factors associated with the acquisition of adolescent healthy lifestyles.},
  author = {Yañez, A. M. and Bennasar-Veny, M. and Leiva, A. and García-Toro, M.},
  journal = {Sci Rep},
  keywords = {grapp-caib},
  number = 1,
  pages = 7911,
  title = {Implications of personality and parental education on healthy lifestyles among adolescents},
  type = {Journal Article},
  volume = 10,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN54
  %A Yañez, A. M.
  %A Bennasar-Veny, M.
  %A Leiva, A.
  %A García-Toro, M.
  %D 2020
  %J Sci Rep
  %N 1
  %P 7911
  %R 10.1038/s41598-020-64850-3
  %T Implications of personality and parental education on healthy lifestyles among adolescents
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220907/pdf/41598_2020_Article_64850.pdf
  %V 10
  %X Several studies have shown an association between personality and health status. The aim of this study was to evaluate the association between personality traits, parental education and health-related lifestyles in a cohort of Spanish adolescents. This is a longitudinal study with a source population of 1,123 third-year students (aged 14-15) in secondary schools in Spain. At the baseline evaluation sociodemographic variables, parental education and personality (Big Five Questionnaire for Children) were collected. At 18 months of follow-up health related lifestyles, including adherence to a healthy diet (KidMed index), tobacco and alcohol consumption, physical exercise, sleep problems and recreative screen and social network time were collected. A total of 824 adolescents (73.4%) completed the 18 months assessment and 695 (84.3%) presented valid data. Higher conscientiousness was associated to a lower risk for non-adherence to Mediterranean diet (OR = 0.7, 95% CIs=0.5-0.9), tobacco (OR = 0.5, 95% CIs=0.3-0.7) and alcohol consumption (OR = 0.6, 95% CIs=0.5-0.8), excessive use of screens (OR = 0.7, 95% CIs=0.5-0.9) and social network sites (OR = 0.7, 95% CIs=0.5-0.8). Higher levels of extraversion was significantly related to a lower risk of physical inactivity (OR = 0.7, 95% CIs=0.6-0.9), but they are at a higher risk of low adherence to Mediterranean diet (OR = 1.3, 95% CIs=1.0-1.7), tobacco (OR = 2.7, 95% CIs=1.7-4.3) and alcohol consumption (OR = 1.9, 95% CIs=1.5-2.4) and excessive use of social network sites (OR = 1.6, 95% CIs=1.3-1.9). High levels of emotional instability were associated with tobacco consumption (OR = 1.5, 95% CIs=1.0-2.2) and sleep problems (OR = 2.0, 95% CIs=1.5-2.7). Finally, we found an association with lower parental education and adolescents' low adherence to Mediterranean diet (OR = 1.6, 95% CIs=1.0-2.4) and sleep problems (OR = 1.8, 95% CIs=1.0-3.0). Cluster analysis of health-related behaviours indicated the presence of two different clusters (unhealthy and healthy adolescents) that were associated with personality traits. Conscientiousness, extraversion, emotional instability and parental education are independent factors associated with the acquisition of adolescent healthy lifestyles.
  

• 
  1.

  Aguilar-Latorre A, Navarro C, Oliván-Blázquez B, Gervilla E, Magallón Botaya R, Calafat-Villalonga C, Garc’ia-Toro M, Boira S, Serrano-Ripoll MJ. Effectiveness and cost-effectiveness of a lifestyle modification programme in the prevention and treatment of subclinical, mild and moderate depression in primary care: a randomised clinical trial protocol. BMJ Open [Internet]. British Medical Journal Publishing Group; 2020;10(12). https://bmjopen.bmj.com/content/10/12/e038457

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Introduction Major depression is a highly prevalent pathology that is currently the second most common cause of disease-induced disability in our society. The onset and continuation of depression may be related to a wide variety of biological and psychosocial factors, many of which are linked to different lifestyle aspects. Therefore, health systems must design and implement health promotion and lifestyle modification programmes (LMPs), taking into account personal factors and facilitators. The main objective of this protocol is to analyse the clinical effectiveness, cost-effectiveness and cost utility of an LMP and an LMP with information and communication technologies (ICTs) as adjunctive treatment for depression in primary care patients. The secondary objectives are to analyse the clinical effectiveness in the subgroup that presents comorbidity and to analyse the correlation between personal factors on health behaviour and lifestyle patterns.Methods and analysis A randomised, multicenter pragmatic clinical trial with three parallel groups consisting of primary healthcare patients suffering from subclinical, mild or moderate depression. The following interventions will be used: (1) Usual antidepressant treatment with psychological advice and/or psychotropic drugs prescribed by the general practitioner (treatment as usual (TAU)). (2) TAU+LMP. A programme to be imparted in six weekly 90-minute group sessions, intended to improve the following aspects: behavioural activation+daily physical activity+adherence to the Mediterranean diet pattern+sleep hygiene+careful exposure to sunlight. (3) TAU+LMP+ICTs: healthy lifestyle recommendations (TAU+LMP)+monitoring using ICTs (a wearable smartwatch). The primary outcome will be the depressive symptomatology and the secondary outcomes will be the quality of life, the use of health and social resources, personal factors on health behaviour, social support, lifestyle patterns and chronic comorbid pathology. Data will be collected before and after the intervention, with 6-month and 12-month follow-ups.Ethics and dissemination This study has been approved by the Clinical Research Ethics Committee of Aragón (approval number: C.P.-C.I. PI18/286) and the Research Ethics Committee of the Balearic Islands (IB3950/19 PI). Data distribution will be anonymous. Results will be disseminated via conferences and papers published in peer-reviewed, open-access journals.Trial registration number ClinicalTrials.gov Registry (NCT03951350).

  @article{Aguilar-Latorree038457,
  abstract = {Introduction Major depression is a highly prevalent pathology that is currently the second most common cause of disease-induced disability in our society. The onset and continuation of depression may be related to a wide variety of biological and psychosocial factors, many of which are linked to different lifestyle aspects. Therefore, health systems must design and implement health promotion and lifestyle modification programmes (LMPs), taking into account personal factors and facilitators. The main objective of this protocol is to analyse the clinical effectiveness, cost-effectiveness and cost utility of an LMP and an LMP with information and communication technologies (ICTs) as adjunctive treatment for depression in primary care patients. The secondary objectives are to analyse the clinical effectiveness in the subgroup that presents comorbidity and to analyse the correlation between personal factors on health behaviour and lifestyle patterns.Methods and analysis A randomised, multicenter pragmatic clinical trial with three parallel groups consisting of primary healthcare patients suffering from subclinical, mild or moderate depression. The following interventions will be used: (1) Usual antidepressant treatment with psychological advice and/or psychotropic drugs prescribed by the general practitioner (treatment as usual (TAU)). (2) TAU+LMP. A programme to be imparted in six weekly 90-minute group sessions, intended to improve the following aspects: behavioural activation+daily physical activity+adherence to the Mediterranean diet pattern+sleep hygiene+careful exposure to sunlight. (3) TAU+LMP+ICTs: healthy lifestyle recommendations (TAU+LMP)+monitoring using ICTs (a wearable smartwatch). The primary outcome will be the depressive symptomatology and the secondary outcomes will be the quality of life, the use of health and social resources, personal factors on health behaviour, social support, lifestyle patterns and chronic comorbid pathology. Data will be collected before and after the intervention, with 6-month and 12-month follow-ups.Ethics and dissemination This study has been approved by the Clinical Research Ethics Committee of Aragón (approval number: C.P.-C.I. PI18/286) and the Research Ethics Committee of the Balearic Islands (IB3950/19 PI). Data distribution will be anonymous. Results will be disseminated via conferences and papers published in peer-reviewed, open-access journals.Trial registration number ClinicalTrials.gov Registry (NCT03951350).},
  author = {Aguilar-Latorre, Alejandra and Navarro, Capilla and Oliván-Blázquez, Bárbara and Gervilla, Elena and Magallón Botaya, Rosa and Calafat-Villalonga, Catalina and Garc'ia-Toro, Mauro and Boira, Santiago and Serrano-Ripoll, Mar'ia Jesús},
  journal = {BMJ Open},
  keywords = {grapp-caib},
  number = 12,
  publisher = {British Medical Journal Publishing Group},
  title = {Effectiveness and cost-effectiveness of a lifestyle modification programme in the prevention and treatment of subclinical, mild and moderate depression in primary care: a randomised clinical trial protocol},
  volume = 10,
  year = 2020
  }
  

  %0 Journal Article
  %1 Aguilar-Latorree038457
  %A Aguilar-Latorre, Alejandra
  %A Navarro, Capilla
  %A Oliván-Blázquez, Bárbara
  %A Gervilla, Elena
  %A Magallón Botaya, Rosa
  %A Calafat-Villalonga, Catalina
  %A Garc'ia-Toro, Mauro
  %A Boira, Santiago
  %A Serrano-Ripoll, Mar'ia Jesús
  %D 2020
  %I British Medical Journal Publishing Group
  %J BMJ Open
  %N 12
  %R 10.1136/bmjopen-2020-038457
  %T Effectiveness and cost-effectiveness of a lifestyle modification programme in the prevention and treatment of subclinical, mild and moderate depression in primary care: a randomised clinical trial protocol
  %U https://bmjopen.bmj.com/content/10/12/e038457
  %V 10
  %X Introduction Major depression is a highly prevalent pathology that is currently the second most common cause of disease-induced disability in our society. The onset and continuation of depression may be related to a wide variety of biological and psychosocial factors, many of which are linked to different lifestyle aspects. Therefore, health systems must design and implement health promotion and lifestyle modification programmes (LMPs), taking into account personal factors and facilitators. The main objective of this protocol is to analyse the clinical effectiveness, cost-effectiveness and cost utility of an LMP and an LMP with information and communication technologies (ICTs) as adjunctive treatment for depression in primary care patients. The secondary objectives are to analyse the clinical effectiveness in the subgroup that presents comorbidity and to analyse the correlation between personal factors on health behaviour and lifestyle patterns.Methods and analysis A randomised, multicenter pragmatic clinical trial with three parallel groups consisting of primary healthcare patients suffering from subclinical, mild or moderate depression. The following interventions will be used: (1) Usual antidepressant treatment with psychological advice and/or psychotropic drugs prescribed by the general practitioner (treatment as usual (TAU)). (2) TAU+LMP. A programme to be imparted in six weekly 90-minute group sessions, intended to improve the following aspects: behavioural activation+daily physical activity+adherence to the Mediterranean diet pattern+sleep hygiene+careful exposure to sunlight. (3) TAU+LMP+ICTs: healthy lifestyle recommendations (TAU+LMP)+monitoring using ICTs (a wearable smartwatch). The primary outcome will be the depressive symptomatology and the secondary outcomes will be the quality of life, the use of health and social resources, personal factors on health behaviour, social support, lifestyle patterns and chronic comorbid pathology. Data will be collected before and after the intervention, with 6-month and 12-month follow-ups.Ethics and dissemination This study has been approved by the Clinical Research Ethics Committee of Aragón (approval number: C.P.-C.I. PI18/286) and the Research Ethics Committee of the Balearic Islands (IB3950/19 PI). Data distribution will be anonymous. Results will be disseminated via conferences and papers published in peer-reviewed, open-access journals.Trial registration number ClinicalTrials.gov Registry (NCT03951350).
  

• 
  1.

  Sheppard JP, Tucker KL, Davison WJ, Stevens R, Aekplakorn W, Bosworth HB, Bove A, Earle K, Godwin M, Green BB, Hebert P, Heneghan C, Hill N, Hobbs FDR, Kantola I, Kerry SM, Leiva A, Magid DJ, Mant J, Margolis KL, McKinstry B, McLaughlin MA, McNamara K, Omboni S, Ogedegbe O, Parati G, Varis J, Verberk WJ, Wakefield BJ, McManus RJ. Self-monitoring of Blood Pressure in Patients With Hypertension-Related Multi-morbidity: Systematic Review and Individual Patient Data Meta-analysis. Am J Hypertens [Internet]. 2020;33(3):243-51. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162426/pdf/hpz182.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Studies have shown that self-monitoring of blood pressure (BP) is effective when combined with co-interventions, but its efficacy varies in the presence of some co-morbidities. This study examined whether self-monitoring can reduce clinic BP in patients with hypertension-related co-morbidity. METHODS: A systematic review was conducted of articles published in Medline, Embase, and the Cochrane Library up to January 2018. Randomized controlled trials of self-monitoring of BP were selected and individual patient data (IPD) were requested. Contributing studies were prospectively categorized by whether they examined a low/high-intensity co-intervention. Change in BP and likelihood of uncontrolled BP at 12 months were examined according to number and type of hypertension-related co-morbidity in a one-stage IPD meta-analysis. RESULTS: A total of 22 trials were eligible, 16 of which were able to provide IPD for the primary outcome, including 6,522 (89%) participants with follow-up data. Self-monitoring was associated with reduced clinic systolic BP compared to usual care at 12-month follow-up, regardless of the number of hypertension-related co-morbidities (-3.12 mm Hg, [95% confidence intervals -4.78, -1.46 mm Hg]; P value for interaction with number of morbidities = 0.260). Intense interventions were more effective than low-intensity interventions in patients with obesity (P < 0.001 for all outcomes), and possibly stroke (P < 0.004 for BP control outcome only), but this effect was not observed in patients with coronary heart disease, diabetes, or chronic kidney disease. CONCLUSIONS: Self-monitoring lowers BP regardless of the number of hypertension-related co-morbidities, but may only be effective in conditions such obesity or stroke when combined with high-intensity co-interventions.

  @article{RN66,
  abstract = {BACKGROUND: Studies have shown that self-monitoring of blood pressure (BP) is effective when combined with co-interventions, but its efficacy varies in the presence of some co-morbidities. This study examined whether self-monitoring can reduce clinic BP in patients with hypertension-related co-morbidity. METHODS: A systematic review was conducted of articles published in Medline, Embase, and the Cochrane Library up to January 2018. Randomized controlled trials of self-monitoring of BP were selected and individual patient data (IPD) were requested. Contributing studies were prospectively categorized by whether they examined a low/high-intensity co-intervention. Change in BP and likelihood of uncontrolled BP at 12 months were examined according to number and type of hypertension-related co-morbidity in a one-stage IPD meta-analysis. RESULTS: A total of 22 trials were eligible, 16 of which were able to provide IPD for the primary outcome, including 6,522 (89%) participants with follow-up data. Self-monitoring was associated with reduced clinic systolic BP compared to usual care at 12-month follow-up, regardless of the number of hypertension-related co-morbidities (-3.12 mm Hg, [95% confidence intervals -4.78, -1.46 mm Hg]; P value for interaction with number of morbidities = 0.260). Intense interventions were more effective than low-intensity interventions in patients with obesity (P < 0.001 for all outcomes), and possibly stroke (P < 0.004 for BP control outcome only), but this effect was not observed in patients with coronary heart disease, diabetes, or chronic kidney disease. CONCLUSIONS: Self-monitoring lowers BP regardless of the number of hypertension-related co-morbidities, but may only be effective in conditions such obesity or stroke when combined with high-intensity co-interventions.},
  author = {Sheppard, J. P. and Tucker, K. L. and Davison, W. J. and Stevens, R. and Aekplakorn, W. and Bosworth, H. B. and Bove, A. and Earle, K. and Godwin, M. and Green, B. B. and Hebert, P. and Heneghan, C. and Hill, N. and Hobbs, F. D. R. and Kantola, I. and Kerry, S. M. and Leiva, A. and Magid, D. J. and Mant, J. and Margolis, K. L. and McKinstry, B. and McLaughlin, M. A. and McNamara, K. and Omboni, S. and Ogedegbe, O. and Parati, G. and Varis, J. and Verberk, W. J. and Wakefield, B. J. and McManus, R. J.},
  journal = {Am J Hypertens},
  keywords = {grapp-caib},
  number = 3,
  pages = {243-251},
  title = {Self-monitoring of Blood Pressure in Patients With Hypertension-Related Multi-morbidity: Systematic Review and Individual Patient Data Meta-analysis},
  type = {Journal Article},
  volume = 33,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN66
  %A Sheppard, J. P.
  %A Tucker, K. L.
  %A Davison, W. J.
  %A Stevens, R.
  %A Aekplakorn, W.
  %A Bosworth, H. B.
  %A Bove, A.
  %A Earle, K.
  %A Godwin, M.
  %A Green, B. B.
  %A Hebert, P.
  %A Heneghan, C.
  %A Hill, N.
  %A Hobbs, F. D. R.
  %A Kantola, I.
  %A Kerry, S. M.
  %A Leiva, A.
  %A Magid, D. J.
  %A Mant, J.
  %A Margolis, K. L.
  %A McKinstry, B.
  %A McLaughlin, M. A.
  %A McNamara, K.
  %A Omboni, S.
  %A Ogedegbe, O.
  %A Parati, G.
  %A Varis, J.
  %A Verberk, W. J.
  %A Wakefield, B. J.
  %A McManus, R. J.
  %D 2020
  %J Am J Hypertens
  %N 3
  %P 243-251
  %R 10.1093/ajh/hpz182
  %T Self-monitoring of Blood Pressure in Patients With Hypertension-Related Multi-morbidity: Systematic Review and Individual Patient Data Meta-analysis
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162426/pdf/hpz182.pdf
  %V 33
  %X BACKGROUND: Studies have shown that self-monitoring of blood pressure (BP) is effective when combined with co-interventions, but its efficacy varies in the presence of some co-morbidities. This study examined whether self-monitoring can reduce clinic BP in patients with hypertension-related co-morbidity. METHODS: A systematic review was conducted of articles published in Medline, Embase, and the Cochrane Library up to January 2018. Randomized controlled trials of self-monitoring of BP were selected and individual patient data (IPD) were requested. Contributing studies were prospectively categorized by whether they examined a low/high-intensity co-intervention. Change in BP and likelihood of uncontrolled BP at 12 months were examined according to number and type of hypertension-related co-morbidity in a one-stage IPD meta-analysis. RESULTS: A total of 22 trials were eligible, 16 of which were able to provide IPD for the primary outcome, including 6,522 (89%) participants with follow-up data. Self-monitoring was associated with reduced clinic systolic BP compared to usual care at 12-month follow-up, regardless of the number of hypertension-related co-morbidities (-3.12 mm Hg, [95% confidence intervals -4.78, -1.46 mm Hg]; P value for interaction with number of morbidities = 0.260). Intense interventions were more effective than low-intensity interventions in patients with obesity (P < 0.001 for all outcomes), and possibly stroke (P < 0.004 for BP control outcome only), but this effect was not observed in patients with coronary heart disease, diabetes, or chronic kidney disease. CONCLUSIONS: Self-monitoring lowers BP regardless of the number of hypertension-related co-morbidities, but may only be effective in conditions such obesity or stroke when combined with high-intensity co-interventions.
  

• 
  1.

  León-Salas B, Zabaleta-Del-Olmo E, Llobera J, Bolíbar-Ribas B, López-Jiménez T, Casajuana-Closas M, Esteva M. Health status, lifestyle habits, and perceived social support in long-term cancer survivors: a cross-sectional study. BMC Res Notes [Internet]. 2020;13(1):376. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414741/pdf/13104_2020_Article_5218.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  OBJECTIVE: To compare the presence of comorbidities and self-perceived health and social support between long-term cancer survivors and people without a history of cancer from a clinical trial examining the effects of a multiple risk behavior intervention. RESULTS: Of the 4259 people studied, 190 (4.46%) were cancer survivors. They had a mean ± SD age of 62.8 ± 7 years vs. 58.7 ± 8 years (P < 0.01) for non-cancer people and were more likely to be on long-term sick leave (11.9 vs. 3.5%, P < 0.001). No differences were observed for smoking, adherence to the Mediterranean diet, physical activity, obesity, or social support. Cancer survivors were more likely to have worse self-perceived health (OR 1.82; 95% CI 1.02-2.75), more comorbidities (OR 1.68; 95% CI 1.18-2.39), COPD (OR 2.17; 95% CI 1.25-3.78), and depression (OR 1.65; 95% CI 1.06-2.57). Older age and worse self-perceived health were independent predictors of survivorship in the adjusted analysis.

  @article{RN52,
  abstract = {OBJECTIVE: To compare the presence of comorbidities and self-perceived health and social support between long-term cancer survivors and people without a history of cancer from a clinical trial examining the effects of a multiple risk behavior intervention. RESULTS: Of the 4259 people studied, 190 (4.46%) were cancer survivors. They had a mean ± SD age of 62.8 ± 7 years vs. 58.7 ± 8 years (P < 0.01) for non-cancer people and were more likely to be on long-term sick leave (11.9 vs. 3.5%, P < 0.001). No differences were observed for smoking, adherence to the Mediterranean diet, physical activity, obesity, or social support. Cancer survivors were more likely to have worse self-perceived health (OR 1.82; 95% CI 1.02-2.75), more comorbidities (OR 1.68; 95% CI 1.18-2.39), COPD (OR 2.17; 95% CI 1.25-3.78), and depression (OR 1.65; 95% CI 1.06-2.57). Older age and worse self-perceived health were independent predictors of survivorship in the adjusted analysis.},
  author = {León-Salas, B. and Zabaleta-Del-Olmo, E. and Llobera, J. and Bolíbar-Ribas, B. and López-Jiménez, T. and Casajuana-Closas, M. and Esteva, M.},
  journal = {BMC Res Notes},
  keywords = {grapp-caib},
  number = 1,
  pages = 376,
  title = {Health status, lifestyle habits, and perceived social support in long-term cancer survivors: a cross-sectional study},
  type = {Journal Article},
  volume = 13,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN52
  %A León-Salas, B.
  %A Zabaleta-Del-Olmo, E.
  %A Llobera, J.
  %A Bolíbar-Ribas, B.
  %A López-Jiménez, T.
  %A Casajuana-Closas, M.
  %A Esteva, M.
  %D 2020
  %J BMC Res Notes
  %N 1
  %P 376
  %R 10.1186/s13104-020-05218-8
  %T Health status, lifestyle habits, and perceived social support in long-term cancer survivors: a cross-sectional study
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414741/pdf/13104_2020_Article_5218.pdf
  %V 13
  %X OBJECTIVE: To compare the presence of comorbidities and self-perceived health and social support between long-term cancer survivors and people without a history of cancer from a clinical trial examining the effects of a multiple risk behavior intervention. RESULTS: Of the 4259 people studied, 190 (4.46%) were cancer survivors. They had a mean ± SD age of 62.8 ± 7 years vs. 58.7 ± 8 years (P < 0.01) for non-cancer people and were more likely to be on long-term sick leave (11.9 vs. 3.5%, P < 0.001). No differences were observed for smoking, adherence to the Mediterranean diet, physical activity, obesity, or social support. Cancer survivors were more likely to have worse self-perceived health (OR 1.82; 95% CI 1.02-2.75), more comorbidities (OR 1.68; 95% CI 1.18-2.39), COPD (OR 2.17; 95% CI 1.25-3.78), and depression (OR 1.65; 95% CI 1.06-2.57). Older age and worse self-perceived health were independent predictors of survivorship in the adjusted analysis.
  

• 
  1.

  Navarro C, Yáñez AM, Garcia A, Seguí A, Gazquez F, Marino JA, Ibarra O, Serrano-Ripoll MJ, Gomez-Juanes R, Bennasar-Veny M, Salva J, Oliván B, Roca M, Gili M, Garcia-Toro M. Effectiveness of a healthy lifestyle promotion program as adjunctive teletherapy for treatment-resistant major depression during COVID 19 pandemic. Medicine [Internet]. Ovid Technologies (Wolters Kluwer Health); 2020 Nov.;99(45):e22958. https://doi.org/10.1097%2Fmd.0000000000022958

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: Treatment-resistant depression (TRD) has a high prevalence and can be exacerbated by poor physical health and economic hardships, which have become common stressors during the current COVID-19 pandemic. The therapeutic approaches used to treat these patients are not always available, may be not be accepted by some patients, and often require face-to-face interactions. OBJECTIVE: The main aim of this study will be to evaluate the effectiveness of an Internet-based adjuvant lifestyle-based intervention for patients with TRD. METHODS: This will be a parallel, randomized, and controlled clinical trial. A total of 180 patients with TRD will be randomly allocated (1:1:1) to 1 of 3 groups: treatment prescribed by the mental health team and written suggestions for lifestyle changes (placebo control group); treatment prescribed by the mental health team, written suggestions for lifestyle changes, and an 8-week mindfulness-based cognitive therapy program (active control group); or treatment prescribed by the mental health team, written suggestions for lifestyle changes, and an 8-week lifestyle change promotion program (intervention group). We will perform this study during the COVID-19 pandemic, and will administer interventions by teletherapy, and contact participants by telephone calls, text messages, and/or teleconferences. We will collect patient data using questionnaires administered at baseline, immediately after the intervention, and after 6 and 12 months. The primary outcome will be score on the Beck Depression Inventory-II. The secondary outcomes will be score on the Clinical Global Impressions Scale (used to quantify and track patient progress and treatment response over time) and health-related quality of life measured using the European Quality of Life-5 Dimensions Questionnaire. DISCUSSION: Patients with TRD are especially vulnerable when face-to-face psychotherapy is unavailable. The main strength of the proposed study is the novelty of the intervention to be used as an adjuvant therapy. Our results may provide guidance for treatment of patients with TRD in future situations that require lockdown measures. CLINICALTRIALS REGISTRATION NUMBER: NCT04428099.

  @article{Navarro_2020,
  abstract = {INTRODUCTION: Treatment-resistant depression (TRD) has a high prevalence and can be exacerbated by poor physical health and economic hardships, which have become common stressors during the current COVID-19 pandemic. The therapeutic approaches used to treat these patients are not always available, may be not be accepted by some patients, and often require face-to-face interactions. OBJECTIVE: The main aim of this study will be to evaluate the effectiveness of an Internet-based adjuvant lifestyle-based intervention for patients with TRD. METHODS: This will be a parallel, randomized, and controlled clinical trial. A total of 180 patients with TRD will be randomly allocated (1:1:1) to 1 of 3 groups: treatment prescribed by the mental health team and written suggestions for lifestyle changes (placebo control group); treatment prescribed by the mental health team, written suggestions for lifestyle changes, and an 8-week mindfulness-based cognitive therapy program (active control group); or treatment prescribed by the mental health team, written suggestions for lifestyle changes, and an 8-week lifestyle change promotion program (intervention group). We will perform this study during the COVID-19 pandemic, and will administer interventions by teletherapy, and contact participants by telephone calls, text messages, and/or teleconferences. We will collect patient data using questionnaires administered at baseline, immediately after the intervention, and after 6 and 12 months. The primary outcome will be score on the Beck Depression Inventory-II. The secondary outcomes will be score on the Clinical Global Impressions Scale (used to quantify and track patient progress and treatment response over time) and health-related quality of life measured using the European Quality of Life-5 Dimensions Questionnaire. DISCUSSION: Patients with TRD are especially vulnerable when face-to-face psychotherapy is unavailable. The main strength of the proposed study is the novelty of the intervention to be used as an adjuvant therapy. Our results may provide guidance for treatment of patients with TRD in future situations that require lockdown measures. CLINICALTRIALS REGISTRATION NUMBER: NCT04428099.},
  author = {Navarro, C. and Yáñez, A. M. and Garcia, A. and Seguí, A. and Gazquez, F. and Marino, J. A. and Ibarra, O. and Serrano-Ripoll, M. J. and Gomez-Juanes, R. and Bennasar-Veny, M. and Salva, J. and Oliván, B. and Roca, M. and Gili, M. and Garcia-Toro, M.},
  journal = {Medicine},
  keywords = {grapp-caib},
  month = {nov},
  number = 45,
  pages = {e22958},
  publisher = {Ovid Technologies (Wolters Kluwer Health)},
  title = {Effectiveness of a healthy lifestyle promotion program as adjunctive teletherapy for treatment-resistant major depression during COVID 19 pandemic},
  volume = 99,
  year = 2020
  }
  

  %0 Journal Article
  %1 Navarro_2020
  %A Navarro, C.
  %A Yáñez, A. M.
  %A Garcia, A.
  %A Seguí, A.
  %A Gazquez, F.
  %A Marino, J. A.
  %A Ibarra, O.
  %A Serrano-Ripoll, M. J.
  %A Gomez-Juanes, R.
  %A Bennasar-Veny, M.
  %A Salva, J.
  %A Oliván, B.
  %A Roca, M.
  %A Gili, M.
  %A Garcia-Toro, M.
  %D 2020
  %I Ovid Technologies (Wolters Kluwer Health)
  %J Medicine
  %N 45
  %P e22958
  %R 10.1097/md.0000000000022958
  %T Effectiveness of a healthy lifestyle promotion program as adjunctive teletherapy for treatment-resistant major depression during COVID 19 pandemic
  %U https://doi.org/10.1097%2Fmd.0000000000022958
  %V 99
  %X INTRODUCTION: Treatment-resistant depression (TRD) has a high prevalence and can be exacerbated by poor physical health and economic hardships, which have become common stressors during the current COVID-19 pandemic. The therapeutic approaches used to treat these patients are not always available, may be not be accepted by some patients, and often require face-to-face interactions. OBJECTIVE: The main aim of this study will be to evaluate the effectiveness of an Internet-based adjuvant lifestyle-based intervention for patients with TRD. METHODS: This will be a parallel, randomized, and controlled clinical trial. A total of 180 patients with TRD will be randomly allocated (1:1:1) to 1 of 3 groups: treatment prescribed by the mental health team and written suggestions for lifestyle changes (placebo control group); treatment prescribed by the mental health team, written suggestions for lifestyle changes, and an 8-week mindfulness-based cognitive therapy program (active control group); or treatment prescribed by the mental health team, written suggestions for lifestyle changes, and an 8-week lifestyle change promotion program (intervention group). We will perform this study during the COVID-19 pandemic, and will administer interventions by teletherapy, and contact participants by telephone calls, text messages, and/or teleconferences. We will collect patient data using questionnaires administered at baseline, immediately after the intervention, and after 6 and 12 months. The primary outcome will be score on the Beck Depression Inventory-II. The secondary outcomes will be score on the Clinical Global Impressions Scale (used to quantify and track patient progress and treatment response over time) and health-related quality of life measured using the European Quality of Life-5 Dimensions Questionnaire. DISCUSSION: Patients with TRD are especially vulnerable when face-to-face psychotherapy is unavailable. The main strength of the proposed study is the novelty of the intervention to be used as an adjuvant therapy. Our results may provide guidance for treatment of patients with TRD in future situations that require lockdown measures. CLINICALTRIALS REGISTRATION NUMBER: NCT04428099.
  

• 
  1.

  Pérula de Torres LA, Moscosio Cuevas JI, Bartolomé Moreno C, Martín-Carrillo P, Martín-Rabadán M, Jiménez García C. [Knowledge, conduct and attitude before the European Code against Cancer by health professionals of primary care]. Aten Primaria [Internet]. 2020;52(2):67-76. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025965/pdf/main.pdf

  AbstractURLBibTeXEndNoteDOIBibSonomy

  OBJECTIVE: To decide if Primary Care (PC) professionals know the European Code against Cancer (CECC) and if this relates to practice the recommendations with themselves and with their patients. DESIGN: descriptive, observational study. SETTING: Spanish Health Centers. PARTICIPANTS: Health professionals. INTERVENTIONS: self-administered questionnaire. MAIN MEASUREMENTS: cancer protective and risk factors, screening for colorectal, breast, cervix and prostate cancer, level of knowledge of the ECAC. RESULTS: 1734 participants (10.5%), mean age 47.4 years (SD: 8.6), 71.5% female. 50.0% do not know the CECC; tutors (OR=1.61), assigned to the PAPPS (OR=1.51) and who have been working in AP for more time (OR=2.62) are the ones who know it most. 7.2% smoke and 79.1% drink alcohol. 64.1% presented normal weight and 19% performed physical activity. They avoid exposing themselves to the sun 52.7% and use protectors 53.8%. 85.2% have never had a colorectal screening, 11% never had a cytology, and 12% had a mammogram. There is a relationship between knowing the CECC and smoking (P<.001), overweight/obesity (P=.024), physical activity (P=.003), meat intake (P<.001), mammography (P<.001), cytology (P=.022), PSA (P=.045), as well as the promotion of their advice among patients. CONCLUSIONS: The CECC is unknown by half of the AP professionals. The practice of its recommendations is uneven, with the prevalence of low smoking, and sun protection a little extended behavior. Those who know him are the ones who most practice his recommendations.

  @article{RN58,
  abstract = {OBJECTIVE: To decide if Primary Care (PC) professionals know the European Code against Cancer (CECC) and if this relates to practice the recommendations with themselves and with their patients. DESIGN: descriptive, observational study. SETTING: Spanish Health Centers. PARTICIPANTS: Health professionals. INTERVENTIONS: self-administered questionnaire. MAIN MEASUREMENTS: cancer protective and risk factors, screening for colorectal, breast, cervix and prostate cancer, level of knowledge of the ECAC. RESULTS: 1734 participants (10.5%), mean age 47.4 years (SD: 8.6), 71.5% female. 50.0% do not know the CECC; tutors (OR=1.61), assigned to the PAPPS (OR=1.51) and who have been working in AP for more time (OR=2.62) are the ones who know it most. 7.2% smoke and 79.1% drink alcohol. 64.1% presented normal weight and 19% performed physical activity. They avoid exposing themselves to the sun 52.7% and use protectors 53.8%. 85.2% have never had a colorectal screening, 11% never had a cytology, and 12% had a mammogram. There is a relationship between knowing the CECC and smoking (P<.001), overweight/obesity (P=.024), physical activity (P=.003), meat intake (P<.001), mammography (P<.001), cytology (P=.022), PSA (P=.045), as well as the promotion of their advice among patients. CONCLUSIONS: The CECC is unknown by half of the AP professionals. The practice of its recommendations is uneven, with the prevalence of low smoking, and sun protection a little extended behavior. Those who know him are the ones who most practice his recommendations.},
  author = {Pérula de Torres, L. A. and Moscosio Cuevas, J. I. and Bartolomé Moreno, C. and Martín-Carrillo, P. and Martín-Rabadán, M. and Jiménez García, C.},
  journal = {Aten Primaria},
  keywords = {grapp-caib},
  number = 2,
  pages = {67-76},
  title = {[Knowledge, conduct and attitude before the European Code against Cancer by health professionals of primary care]},
  type = {Journal Article},
  volume = 52,
  year = 2020
  }
  

  %0 Journal Article
  %1 RN58
  %A Pérula de Torres, L. A.
  %A Moscosio Cuevas, J. I.
  %A Bartolomé Moreno, C.
  %A Martín-Carrillo, P.
  %A Martín-Rabadán, M.
  %A Jiménez García, C.
  %D 2020
  %J Aten Primaria
  %N 2
  %P 67-76
  %R 10.1016/j.aprim.2018.11.002
  %T [Knowledge, conduct and attitude before the European Code against Cancer by health professionals of primary care]
  %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025965/pdf/main.pdf
  %V 52
  %X OBJECTIVE: To decide if Primary Care (PC) professionals know the European Code against Cancer (CECC) and if this relates to practice the recommendations with themselves and with their patients. DESIGN: descriptive, observational study. SETTING: Spanish Health Centers. PARTICIPANTS: Health professionals. INTERVENTIONS: self-administered questionnaire. MAIN MEASUREMENTS: cancer protective and risk factors, screening for colorectal, breast, cervix and prostate cancer, level of knowledge of the ECAC. RESULTS: 1734 participants (10.5%), mean age 47.4 years (SD: 8.6), 71.5% female. 50.0% do not know the CECC; tutors (OR=1.61), assigned to the PAPPS (OR=1.51) and who have been working in AP for more time (OR=2.62) are the ones who know it most. 7.2% smoke and 79.1% drink alcohol. 64.1% presented normal weight and 19% performed physical activity. They avoid exposing themselves to the sun 52.7% and use protectors 53.8%. 85.2% have never had a colorectal screening, 11% never had a cytology, and 12% had a mammogram. There is a relationship between knowing the CECC and smoking (P<.001), overweight/obesity (P=.024), physical activity (P=.003), meat intake (P<.001), mammography (P<.001), cytology (P=.022), PSA (P=.045), as well as the promotion of their advice among patients. CONCLUSIONS: The CECC is unknown by half of the AP professionals. The practice of its recommendations is uneven, with the prevalence of low smoking, and sun protection a little extended behavior. Those who know him are the ones who most practice his recommendations.
  

• 
  1.

  Molina-Mula J, Miguélez-Chamorro A, Taltavull-Aparicio JM, Miralles-Xamena J, del Carmen Ortego-Mate M. Quality of Life and Dependence Degree of Chronic Patients in a Chronicity Care Model. Healthcare [Internet]. MDPI AG; 2020 Aug.;8(3):293. https://doi.org/10.3390%2Fhealthcare8030293

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Molina-Mula, J. Miguélez-Chamorro, A. Taltavull-Aparicio, J. M. Miralles-Xamena, J. Ortego-Mate, M. D. C.

  @article{Molina_Mula_2020,
  abstract = {Molina-Mula, J. Miguélez-Chamorro, A. Taltavull-Aparicio, J. M. Miralles-Xamena, J. Ortego-Mate, M. D. C.},
  author = {Molina-Mula, Jesús and Miguélez-Chamorro, Angélica and Taltavull-Aparicio, Joana Mar'ia and Miralles-Xamena, Jerónima and del Carmen Ortego-Mate, Mar'ia},
  journal = {Healthcare},
  keywords = {grapp-caib},
  month = {aug},
  number = 3,
  pages = 293,
  publisher = {MDPI AG},
  title = {Quality of Life and Dependence Degree of Chronic Patients in a Chronicity Care Model},
  volume = 8,
  year = 2020
  }
  

  %0 Journal Article
  %1 Molina_Mula_2020
  %A Molina-Mula, Jesús
  %A Miguélez-Chamorro, Angélica
  %A Taltavull-Aparicio, Joana Mar'ia
  %A Miralles-Xamena, Jerónima
  %A del Carmen Ortego-Mate, Mar'ia
  %D 2020
  %I MDPI AG
  %J Healthcare
  %N 3
  %P 293
  %R 10.3390/healthcare8030293
  %T Quality of Life and Dependence Degree of Chronic Patients in a Chronicity Care Model
  %U https://doi.org/10.3390%2Fhealthcare8030293
  %V 8
  %X Molina-Mula, J. Miguélez-Chamorro, A. Taltavull-Aparicio, J. M. Miralles-Xamena, J. Ortego-Mate, M. D. C.
  

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  (NCD-RisC) NRFC. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. Int J Epidemiol [Internet]. 2020;49(1):173-92. https://watermark.silverchair.com/dyz099.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArowggK2BgkqhkiG9w0BBwagggKnMIICowIBADCCApwGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM_bmGah0qXJ3QZy3tAgEQgIICbTA-OcaA-F4KNJGCgAsHpDCTA6wCBab0V66NEeCq1SH1CEFzHwNif5uZvdBA0xqx_kT1EYjXRLs81jlF1lQD93MpFLLVR6_L8jfQNccBLn79aAil03FxoqnHokhqz45Le96yZbFpa5TbZUC5NiWOzAriu_YZvNJIZGAsywWbUUjyG_d3apjUE8synC633oC5Nk7MIS0KC1q9bv2QfaLqMofUd352V3pp_CkCFM3rUl_kMH-CdPtu0ZUT-APYeNnyIWJBwu3F3HmgaK32mmq_fe7ss16Mq10IYL09xhCRdyPeydI7XlNwZgMh1OK7uDM5YcihQ7ZebP0ODlyOpbKrYS6zBwZYFzEGwgeJn2ydzKlfqdmUyqVhjW8fFuABhwhylFLe3ujfnFvZfUGImunZDIMHyhR66thstISP3glb1a73T344V5mSerV8SVTZzXm9btiwAbhenCtqe-TsLsxWjfMRiRIMu37iYcwi6WpF4mpUAeTZUCLM7Gx-AfPqiIcov4qzKJknJcmadgzu4GbsyKlbh3dAwZS-q0Fe5Dmbqao4MVfxwdnI7zuSUjZBiFqea3C1N6AZ9h8zQg8JbacJr1uT_DBMDMGR_7y7lbWUUe55b3yQcm0vF-Na78n6-L0grkDK3T0ikYaSMc-FukRoNDb1CoBlMT8aOBqlzNlPzcw3eMMSGuU8WWi3B3wr636wMC4B-U5ROakmUvbQM0PERnyEtspEhYArrbm6V6kHsIbU5EuhqAh6lJ9-q0DBkp5bIYCkBNGczFGPmKp4evgEGT89U0hx2dfyVsPCTz5OnSg1ICYt2nT1CCm0AuIvmg

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  BACKGROUND: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. METHODS: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. RESULTS: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. CONCLUSIONS: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.

  @article{RN60,
  abstract = {BACKGROUND: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. METHODS: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. RESULTS: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. CONCLUSIONS: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.},
  author = {(NCD-RisC), NCD Risk Factor Collaboration},
  journal = {Int J Epidemiol},
  keywords = {grapp-caib},
  number = 1,
  pages = {173-192},
  title = {National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries},
  type =