2026

• 
  1.

  Riera-Serra P, Serrano-Ripoll MJ, Fiol deRoque MA, García-Pazo P, Bennasar-Veny M, Yánez-Juan A, Leiva-Rus A, Ginard-Puigserver M, García-Toro M, Sitges C, Balle M, Gervilla E, Gonzalez-Garcia X, García-Buades ME, Blanes MW, Zamanillo-Campos R, Andreu-Rodrigo P, Ricci-Cabello I. Evaluation of the effectiveness of SOM-RIU, a multifaceted, school-based, suicide prevention intervention targeted to Spanish adolescents: study protocol for a cluster-randomised controlled trial. BMC Psychiatry. 2026;26(1):56.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Adolescent suicide is a major public health concern and the third leading cause of death among young people worldwide. Schools are widely recognized as effective settings for universal mental health promotion and suicide prevention. This study aims to evaluate the effectiveness of SOM-RIU, a multifaceted school-based intervention involving pupils and gatekeepers (teachers and parents) in preventing suicidal behaviour and promoting adolescent mental health. METHODS: We will conduct a six-month, two-arm, cluster-randomised controlled trial. We will recruit 2,280 pupils from 114 classrooms in 38 secondary schools across the Balearic Islands (Spain). Eligible pupils will be aged 12–16 and enrolled in the 2nd and 3rd years of compulsory secondary education. Schools will be randomly assigned (1:1) to either the intervention or control group. Schools in the intervention group will implement the SOM-RIU programme, which includes four weekly psychoeducational sessions for pupils, delivered by trained educational psychologists. These sessions focus on mental health literacy, emotional regulation, suicide risk detection and management, and help-seeking strategies. In parallel, gatekeepers (teachers and parents) will receive a digital educational co-intervention consisting in four multimedia modules to strengthen their role in suicide prevention. Schools in the control group will receive a minimal intervention consisting of educational posters on mental health and suicide prevention displayed within school premises. The primary outcome will be suicidal ideation (Paykel Suicide Scale). Secondary outcomes will include suicide attempts, depression symptoms, well-being, self-harm, substance use, internet addiction, bullying, and cognitive disconnection. Teachers and parents will report on suicide-related knowledge, self-efficacy, and student referrals. Data will be collected at baseline and six-month follow-up. Analyses will be conducted using generalized linear mixed models to account for clustering, and multiple imputation will be used for missing data. A qualitative process evaluation will explore implementation, acceptability, and perceived impact of the intervention, while also examining contextual factors and potential mechanisms of action that may have influenced the outcomes. DISCUSSION: This trial will generate evidence on the effectiveness of multifaceted, school-based suicide prevention interventions for adolescents. If effective, the SOM-RIU programme could serve as a practical model for enhancing mental health support within educational settings in Spain. TRIAL REGISTRATION: NCT06996054 (clinicaltrials.gov). Registration date: 2025-05-30. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-025-07570-0.

  @article{RN7,
  abstract = {BACKGROUND: Adolescent suicide is a major public health concern and the third leading cause of death among young people worldwide. Schools are widely recognized as effective settings for universal mental health promotion and suicide prevention. This study aims to evaluate the effectiveness of SOM-RIU, a multifaceted school-based intervention involving pupils and gatekeepers (teachers and parents) in preventing suicidal behaviour and promoting adolescent mental health. METHODS: We will conduct a six-month, two-arm, cluster-randomised controlled trial. We will recruit 2,280 pupils from 114 classrooms in 38 secondary schools across the Balearic Islands (Spain). Eligible pupils will be aged 12–16 and enrolled in the 2nd and 3rd years of compulsory secondary education. Schools will be randomly assigned (1:1) to either the intervention or control group. Schools in the intervention group will implement the SOM-RIU programme, which includes four weekly psychoeducational sessions for pupils, delivered by trained educational psychologists. These sessions focus on mental health literacy, emotional regulation, suicide risk detection and management, and help-seeking strategies. In parallel, gatekeepers (teachers and parents) will receive a digital educational co-intervention consisting in four multimedia modules to strengthen their role in suicide prevention. Schools in the control group will receive a minimal intervention consisting of educational posters on mental health and suicide prevention displayed within school premises. The primary outcome will be suicidal ideation (Paykel Suicide Scale). Secondary outcomes will include suicide attempts, depression symptoms, well-being, self-harm, substance use, internet addiction, bullying, and cognitive disconnection. Teachers and parents will report on suicide-related knowledge, self-efficacy, and student referrals. Data will be collected at baseline and six-month follow-up. Analyses will be conducted using generalized linear mixed models to account for clustering, and multiple imputation will be used for missing data. A qualitative process evaluation will explore implementation, acceptability, and perceived impact of the intervention, while also examining contextual factors and potential mechanisms of action that may have influenced the outcomes. DISCUSSION: This trial will generate evidence on the effectiveness of multifaceted, school-based suicide prevention interventions for adolescents. If effective, the SOM-RIU programme could serve as a practical model for enhancing mental health support within educational settings in Spain. TRIAL REGISTRATION: NCT06996054 (clinicaltrials.gov). Registration date: 2025-05-30. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-025-07570-0.},
  author = {Riera-Serra, P. and Serrano-Ripoll, M. J. and Fiol deRoque, M. A. and García-Pazo, P. and Bennasar-Veny, M. and Yánez-Juan, A. and Leiva-Rus, A. and Ginard-Puigserver, M. and García-Toro, M. and Sitges, C. and Balle, M. and Gervilla, E. and Gonzalez-Garcia, X. and García-Buades, M. E. and Blanes, M. W. and Zamanillo-Campos, R. and Andreu-Rodrigo, P. and Ricci-Cabello, I.},
  journal = {BMC Psychiatry},
  keywords = {evisap},
  number = 1,
  pages = 56,
  title = {Evaluation of the effectiveness of SOM-RIU, a multifaceted, school-based, suicide prevention intervention targeted to Spanish adolescents: study protocol for a cluster-randomised controlled trial},
  type = {Journal Article},
  volume = 26,
  year = 2026
  }
  

  %0 Journal Article
  %1 RN7
  %A Riera-Serra, P.
  %A Serrano-Ripoll, M. J.
  %A Fiol deRoque, M. A.
  %A García-Pazo, P.
  %A Bennasar-Veny, M.
  %A Yánez-Juan, A.
  %A Leiva-Rus, A.
  %A Ginard-Puigserver, M.
  %A García-Toro, M.
  %A Sitges, C.
  %A Balle, M.
  %A Gervilla, E.
  %A Gonzalez-Garcia, X.
  %A García-Buades, M. E.
  %A Blanes, M. W.
  %A Zamanillo-Campos, R.
  %A Andreu-Rodrigo, P.
  %A Ricci-Cabello, I.
  %D 2026
  %J BMC Psychiatry
  %N 1
  %P 56
  %R 10.1186/s12888-025-07570-0
  %T Evaluation of the effectiveness of SOM-RIU, a multifaceted, school-based, suicide prevention intervention targeted to Spanish adolescents: study protocol for a cluster-randomised controlled trial
  %V 26
  %X BACKGROUND: Adolescent suicide is a major public health concern and the third leading cause of death among young people worldwide. Schools are widely recognized as effective settings for universal mental health promotion and suicide prevention. This study aims to evaluate the effectiveness of SOM-RIU, a multifaceted school-based intervention involving pupils and gatekeepers (teachers and parents) in preventing suicidal behaviour and promoting adolescent mental health. METHODS: We will conduct a six-month, two-arm, cluster-randomised controlled trial. We will recruit 2,280 pupils from 114 classrooms in 38 secondary schools across the Balearic Islands (Spain). Eligible pupils will be aged 12–16 and enrolled in the 2nd and 3rd years of compulsory secondary education. Schools will be randomly assigned (1:1) to either the intervention or control group. Schools in the intervention group will implement the SOM-RIU programme, which includes four weekly psychoeducational sessions for pupils, delivered by trained educational psychologists. These sessions focus on mental health literacy, emotional regulation, suicide risk detection and management, and help-seeking strategies. In parallel, gatekeepers (teachers and parents) will receive a digital educational co-intervention consisting in four multimedia modules to strengthen their role in suicide prevention. Schools in the control group will receive a minimal intervention consisting of educational posters on mental health and suicide prevention displayed within school premises. The primary outcome will be suicidal ideation (Paykel Suicide Scale). Secondary outcomes will include suicide attempts, depression symptoms, well-being, self-harm, substance use, internet addiction, bullying, and cognitive disconnection. Teachers and parents will report on suicide-related knowledge, self-efficacy, and student referrals. Data will be collected at baseline and six-month follow-up. Analyses will be conducted using generalized linear mixed models to account for clustering, and multiple imputation will be used for missing data. A qualitative process evaluation will explore implementation, acceptability, and perceived impact of the intervention, while also examining contextual factors and potential mechanisms of action that may have influenced the outcomes. DISCUSSION: This trial will generate evidence on the effectiveness of multifaceted, school-based suicide prevention interventions for adolescents. If effective, the SOM-RIU programme could serve as a practical model for enhancing mental health support within educational settings in Spain. TRIAL REGISTRATION: NCT06996054 (clinicaltrials.gov). Registration date: 2025-05-30. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-025-07570-0.
  

• 
  1.

  Gervilla-García E, García-Pazo P, Guillén-Solà M, Leguizamo F, Ricci-Cabello I, Serrano-Ripoll MJ, Bennasar-Veny M, Fiol deRoque MA, Angullo-Martínez E, Zamanillo-Campos R. Stakeholder Perspectives on Implementing DiabeText: Exploring Barriers and Facilitators for a Personalized Diabetes Self-Management SMS Intervention in Spain. Diabetology. 2026;7:17.

  AbstractBibTeXEndNoteBibSonomyDownload

  Background/Objectives: Mobile health (mHealth) interventions can enhance chronic disease management, but their integration into public healthcare systems remains complex. DiabeText is the first SMS-based intervention in Spain delivering personalized diabetes self-management support using electronic health record data. This study explored perceived barriers and facilitators to the implementation of DiabeText in the Spanish public health context from the perspective of key stakeholders. Methods: A qualitative study was conducted using semi-structured interviews with 14 purposively selected stakeholders involved in digital health, diabetes care, data protection, and healthcare management across several Spanish regions. Interviews were thematically analyzed using Braun and Clarke’s approach and guided by the Implementation Research Logic Model. Results: Participants reported several barriers, including concerns regarding data protection, uncertainty about long-term sustainability, insufficient training and engagement of healthcare professionals and low digital literacy among certain patient groups. Facilitators included favorable institutional momentum for digital innovation, funding availability, perceived clinical utility and scalability of DiabeText, and growing patient familiarity with digital tools. Recommended strategies included integration into existing healthcare systems and workflows, professional training and use of familiar communication platforms. Conclusions: Effective implementation of DiabeText requires addressing regulatory, organizational, and equity-related barriers while leveraging institutional support and readiness for innovation. Early involvement of healthcare professionals, robust data governance, and investment in digital literacy are essential to ensure sustainable and equitable adoption. These findings provide actionable insights to support the integration of mHealth tools into chronic disease care in Spain and similar settings.

  @article{gervillagarcia2026stakeholder,
  abstract = {Background/Objectives: Mobile health (mHealth) interventions can enhance chronic disease management, but their integration into public healthcare systems remains complex. DiabeText is the first SMS-based intervention in Spain delivering personalized diabetes self-management support using electronic health record data. This study explored perceived barriers and facilitators to the implementation of DiabeText in the Spanish public health context from the perspective of key stakeholders. Methods: A qualitative study was conducted using semi-structured interviews with 14 purposively selected stakeholders involved in digital health, diabetes care, data protection, and healthcare management across several Spanish regions. Interviews were thematically analyzed using Braun and Clarke’s approach and guided by the Implementation Research Logic Model. Results: Participants reported several barriers, including concerns regarding data protection, uncertainty about long-term sustainability, insufficient training and engagement of healthcare professionals and low digital literacy among certain patient groups. Facilitators included favorable institutional momentum for digital innovation, funding availability, perceived clinical utility and scalability of DiabeText, and growing patient familiarity with digital tools. Recommended strategies included integration into existing healthcare systems and workflows, professional training and use of familiar communication platforms. Conclusions: Effective implementation of DiabeText requires addressing regulatory, organizational, and equity-related barriers while leveraging institutional support and readiness for innovation. Early involvement of healthcare professionals, robust data governance, and investment in digital literacy are essential to ensure sustainable and equitable adoption. These findings provide actionable insights to support the integration of mHealth tools into chronic disease care in Spain and similar settings.},
  author = {Gervilla-García, Elena and García-Pazo, Patricia and Guillén-Solà, Mireia and Leguizamo, Federico and Ricci-Cabello, Ignacio and Serrano-Ripoll, María J. and Bennasar-Veny, Miquel and Fiol deRoque, Maria A. and Angullo-Martínez, Escarlata and Zamanillo-Campos, Rocío},
  booktitle = {Diabetology},
  keywords = {evisap telemedicine},
  pages = 17,
  series = 1,
  title = {Stakeholder Perspectives on Implementing DiabeText: Exploring Barriers and Facilitators for a Personalized Diabetes Self-Management SMS Intervention in Spain},
  volume = 7,
  year = 2026
  }
  

  %0 Journal Article
  %1 gervillagarcia2026stakeholder
  %A Gervilla-García, Elena
  %A García-Pazo, Patricia
  %A Guillén-Solà, Mireia
  %A Leguizamo, Federico
  %A Ricci-Cabello, Ignacio
  %A Serrano-Ripoll, María J.
  %A Bennasar-Veny, Miquel
  %A Fiol deRoque, Maria A.
  %A Angullo-Martínez, Escarlata
  %A Zamanillo-Campos, Rocío
  %B Diabetology
  %D 2026
  %P 17
  %T Stakeholder Perspectives on Implementing DiabeText: Exploring Barriers and Facilitators for a Personalized Diabetes Self-Management SMS Intervention in Spain
  %V 7
  %X Background/Objectives: Mobile health (mHealth) interventions can enhance chronic disease management, but their integration into public healthcare systems remains complex. DiabeText is the first SMS-based intervention in Spain delivering personalized diabetes self-management support using electronic health record data. This study explored perceived barriers and facilitators to the implementation of DiabeText in the Spanish public health context from the perspective of key stakeholders. Methods: A qualitative study was conducted using semi-structured interviews with 14 purposively selected stakeholders involved in digital health, diabetes care, data protection, and healthcare management across several Spanish regions. Interviews were thematically analyzed using Braun and Clarke’s approach and guided by the Implementation Research Logic Model. Results: Participants reported several barriers, including concerns regarding data protection, uncertainty about long-term sustainability, insufficient training and engagement of healthcare professionals and low digital literacy among certain patient groups. Facilitators included favorable institutional momentum for digital innovation, funding availability, perceived clinical utility and scalability of DiabeText, and growing patient familiarity with digital tools. Recommended strategies included integration into existing healthcare systems and workflows, professional training and use of familiar communication platforms. Conclusions: Effective implementation of DiabeText requires addressing regulatory, organizational, and equity-related barriers while leveraging institutional support and readiness for innovation. Early involvement of healthcare professionals, robust data governance, and investment in digital literacy are essential to ensure sustainable and equitable adoption. These findings provide actionable insights to support the integration of mHealth tools into chronic disease care in Spain and similar settings.
  

• 
  1.

  Vieira RJ, Gil-Mata S, Ferreira A, Riera-Serra P, Bognanni A, Duarte VH, Viegas H, Pereira AM, Ferreira-da Silva R, Ferreira-Cardoso H, Marques-Cruz M, Castro-Teles J, Campos-Lopes M, Teixeira-Ferreira A, Lourenço-Silva N, Boechat JL, Borowiack E, Sadowska E, Costa RA, Perestrelo P, Pereira MS, Pereira-Macedo J, Ierodiakonou D, Chu AWL, Calvi IP, Torres MI, Silva Ribeiro RA, Thomander T, Valiulis A, Cherrez-Ojeda I, Bedbrook A, Klimek L, Yepes Nuñez JJ, Zuberbier T, Fonseca JA, Schünemann HJ, Bousquet J, Sousa-Pinto B. Efficacy and safety of oral antihistamines for allergic rhinitis: Network meta-analysis. J Allergy Clin Immunol Pract. 2026;.

  BibTeXEndNoteDOIBibSonomyDownload

  @article{RN6,
  author = {Vieira, R. J. and Gil-Mata, S. and Ferreira, A. and Riera-Serra, P. and Bognanni, A. and Duarte, V. H. and Viegas, H. and Pereira, A. M. and Ferreira-da Silva, R. and Ferreira-Cardoso, H. and Marques-Cruz, M. and Castro-Teles, J. and Campos-Lopes, M. and Teixeira-Ferreira, A. and Lourenço-Silva, N. and Boechat, J. L. and Borowiack, E. and Sadowska, E. and Costa, R. A. and Perestrelo, P. and Pereira, M. S. and Pereira-Macedo, J. and Ierodiakonou, D. and Chu, A. W. L. and Calvi, I. P. and Torres, M. I. and Silva Ribeiro, R. A. and Thomander, T. and Valiulis, A. and Cherrez-Ojeda, I. and Bedbrook, A. and Klimek, L. and Yepes Nuñez, J. J. and Zuberbier, T. and Fonseca, J. A. and Schünemann, H. J. and Bousquet, J. and Sousa-Pinto, B.},
  journal = {J Allergy Clin Immunol Pract},
  keywords = {evisap},
  title = {Efficacy and safety of oral antihistamines for allergic rhinitis: Network meta-analysis},
  type = {Journal Article},
  year = 2026
  }
  

  %0 Journal Article
  %1 RN6
  %A Vieira, R. J.
  %A Gil-Mata, S.
  %A Ferreira, A.
  %A Riera-Serra, P.
  %A Bognanni, A.
  %A Duarte, V. H.
  %A Viegas, H.
  %A Pereira, A. M.
  %A Ferreira-da Silva, R.
  %A Ferreira-Cardoso, H.
  %A Marques-Cruz, M.
  %A Castro-Teles, J.
  %A Campos-Lopes, M.
  %A Teixeira-Ferreira, A.
  %A Lourenço-Silva, N.
  %A Boechat, J. L.
  %A Borowiack, E.
  %A Sadowska, E.
  %A Costa, R. A.
  %A Perestrelo, P.
  %A Pereira, M. S.
  %A Pereira-Macedo, J.
  %A Ierodiakonou, D.
  %A Chu, A. W. L.
  %A Calvi, I. P.
  %A Torres, M. I.
  %A Silva Ribeiro, R. A.
  %A Thomander, T.
  %A Valiulis, A.
  %A Cherrez-Ojeda, I.
  %A Bedbrook, A.
  %A Klimek, L.
  %A Yepes Nuñez, J. J.
  %A Zuberbier, T.
  %A Fonseca, J. A.
  %A Schünemann, H. J.
  %A Bousquet, J.
  %A Sousa-Pinto, B.
  %D 2026
  %J J Allergy Clin Immunol Pract
  %R 10.1016/j.jaip.2025.12.034
  %T Efficacy and safety of oral antihistamines for allergic rhinitis: Network meta-analysis
  

2025

• 
  1.

  Gordito Soler M, Ramírez-Manent JI, Tárraga López PJ, Martínez-Almoyna Rifá E, Paublini H, López González Ángel A. Usefulness of body and visceral fat determined by bioimpedancemetry versus body mass index and waist circumference in the identification of elevated values of different atherogenesis risk scales. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis [Internet]. Spain; 2025 Mar.;:500772-. https://pubmed.ncbi.nlm.nih.gov/40037953

  AbstractURLBibTeXEndNoteDOIBibSonomy

  INTRODUCTION: Obesity and atherogenesis are two highly prevalent pathological processes worldwide that also share several pathophysiological mechanisms. OBJECTIVES: Descriptive and cross-sectional study in 8,590 Spanish workers (4,104 men and 4,486 women) with an average age of 41.5years, in which the usefulness of four scales of overweight and obesity such as body mass index (BMI), waist circumference and percentages of body and visceral fat determined by bioimpedance measurement to identify high levels of atherogenic risk determined by atherogenic dyslipidemia (AD), lipid triad (LT) and several atherogenic indices is assessed. RESULTS: All the overweight and obesity scales show a predictive value between moderate and good, determined by the AUC of the ROC curves, with values ranging from 0.727 to 0.886 in women and 0.676 to 0.885 in men. Of all of them, the one with the highest AUC is visceral fat with values exceeding 0.800 and the lowest are for BMI. In all cases, the AUC is higher in women. CONCLUSIONS: The overweight and obesity scales analysed (BMI, waist circumference and percentage of body and visceral fat) show AUCs for predicting atherogenic risk between moderate and high, with visceral fat being the most useful of all.

  @article{gorditosoler2025usefulness,
  abstract = {INTRODUCTION: Obesity and atherogenesis are two highly prevalent pathological processes worldwide that also share several pathophysiological mechanisms. OBJECTIVES: Descriptive and cross-sectional study in 8,590 Spanish workers (4,104 men and 4,486 women) with an average age of 41.5years, in which the usefulness of four scales of overweight and obesity such as body mass index (BMI), waist circumference and percentages of body and visceral fat determined by bioimpedance measurement to identify high levels of atherogenic risk determined by atherogenic dyslipidemia (AD), lipid triad (LT) and several atherogenic indices is assessed. RESULTS: All the overweight and obesity scales show a predictive value between moderate and good, determined by the AUC of the ROC curves, with values ranging from 0.727 to 0.886 in women and 0.676 to 0.885 in men. Of all of them, the one with the highest AUC is visceral fat with values exceeding 0.800 and the lowest are for BMI. In all cases, the AUC is higher in women. CONCLUSIONS: The overweight and obesity scales analysed (BMI, waist circumference and percentage of body and visceral fat) show AUCs for predicting atherogenic risk between moderate and high, with visceral fat being the most useful of all.},
  address = {Spain},
  author = {Gordito Soler, María and Ramírez-Manent, José Ignacio and Tárraga López, Pedro Juan and Martínez-Almoyna Rifá, Emilio and Paublini, Hernán and López González, Ángel Arturo},
  journal = {Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis},
  keywords = {grapp-caib},
  month = {mar},
  pages = {500772--500772},
  title = {Usefulness of body and visceral fat determined by bioimpedancemetry versus body mass index and waist circumference in the identification of elevated values of different atherogenesis risk scales},
  year = 2025
  }
  

  %0 Journal Article
  %1 gorditosoler2025usefulness
  %A Gordito Soler, María
  %A Ramírez-Manent, José Ignacio
  %A Tárraga López, Pedro Juan
  %A Martínez-Almoyna Rifá, Emilio
  %A Paublini, Hernán
  %A López González, Ángel Arturo
  %C Spain
  %D 2025
  %J Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
  %P 500772--500772
  %R 10.1016/j.arteri.2025.500772
  %T Usefulness of body and visceral fat determined by bioimpedancemetry versus body mass index and waist circumference in the identification of elevated values of different atherogenesis risk scales
  %U https://pubmed.ncbi.nlm.nih.gov/40037953
  %X INTRODUCTION: Obesity and atherogenesis are two highly prevalent pathological processes worldwide that also share several pathophysiological mechanisms. OBJECTIVES: Descriptive and cross-sectional study in 8,590 Spanish workers (4,104 men and 4,486 women) with an average age of 41.5years, in which the usefulness of four scales of overweight and obesity such as body mass index (BMI), waist circumference and percentages of body and visceral fat determined by bioimpedance measurement to identify high levels of atherogenic risk determined by atherogenic dyslipidemia (AD), lipid triad (LT) and several atherogenic indices is assessed. RESULTS: All the overweight and obesity scales show a predictive value between moderate and good, determined by the AUC of the ROC curves, with values ranging from 0.727 to 0.886 in women and 0.676 to 0.885 in men. Of all of them, the one with the highest AUC is visceral fat with values exceeding 0.800 and the lowest are for BMI. In all cases, the AUC is higher in women. CONCLUSIONS: The overweight and obesity scales analysed (BMI, waist circumference and percentage of body and visceral fat) show AUCs for predicting atherogenic risk between moderate and high, with visceral fat being the most useful of all.
  

• 
  1.

  Venter C, Alonso-Coello P, Beltran J, Bracchiglione J, Fernandez-Saenz K, Riera P, Solà I, Arasi S, Berni Canani R, Fleischer D, Eguíluz-Gracia I, Meyer R, Roberts G, Roth-Walter F, Santos AF, Skypala I, Smith PK, Sokolowska M, Torres MJ, Vassilopoulou E, Walter J, O’Mahony L. Protocol: Scoping review of the association between complementary feeding, growth, and immune health in infants and toddlers-An EAACI guideline paper. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Internet]. England; 2025 Aug.;36(8):e70145-e70145. https://pubmed.ncbi.nlm.nih.gov/40747578

  AbstractURLBibTeXEndNoteDOIBibSonomy

  The European Academy of Allergy and Clinical Immunology (EAACI) is currently developing guidelines on immunomodulation and nutrition. To inform these recommendations, a scoping review will be conducted to synthesize and map the available empirical evidence on how complementary feeding affects immune health in infants and toddlers to explore the association between complementary feeding during the first year of life and immune health outcomes in children up to 3 years of age. The scoping review will be conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analysis Scoping Review Extension for scoping reviews (PRISMA-ScR) guidelines. We have developed inclusion criteria using the PCC (Population, Concept and Context) format: the population will include healthy infants; the concept refers to specific factors related to introduction of complementary feeding; and the context will focus on studies conducted in settings representative of everyday nutrition and feeding practices for infants and toddlers. Evidence sources include systematic reviews. We will search in MEDLINE and Epistemonikos. Data will be extracted using a standardized form developed in REDCap, and the findings will be synthesized narratively. Only published literature will be included in this systematic review. Therefore, no ethical approval is required. The final review paper will be published in a peer-reviewed journal. OSF registration DOI: 10.17605/OSF.IO/T5F8.

  @article{venter2025protocol,
  abstract = {The European Academy of Allergy and Clinical Immunology (EAACI) is currently developing guidelines on immunomodulation and nutrition. To inform these recommendations, a scoping review will be conducted to synthesize and map the available empirical evidence on how complementary feeding affects immune health in infants and toddlers to explore the association between complementary feeding during the first year of life and immune health outcomes in children up to 3 years of age. The scoping review will be conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analysis Scoping Review Extension for scoping reviews (PRISMA-ScR) guidelines. We have developed inclusion criteria using the PCC (Population, Concept and Context) format: the population will include healthy infants; the concept refers to specific factors related to introduction of complementary feeding; and the context will focus on studies conducted in settings representative of everyday nutrition and feeding practices for infants and toddlers. Evidence sources include systematic reviews. We will search in MEDLINE and Epistemonikos. Data will be extracted using a standardized form developed in REDCap, and the findings will be synthesized narratively. Only published literature will be included in this systematic review. Therefore, no ethical approval is required. The final review paper will be published in a peer-reviewed journal. OSF registration DOI: 10.17605/OSF.IO/T5F8.},
  address = {England},
  author = {Venter, Carina and Alonso-Coello, Pablo and Beltran, Jessica and Bracchiglione, Javier and Fernandez-Saenz, Karina and Riera, Pau and Solà, Ivan and Arasi, Stefania and Berni Canani, Roberto and Fleischer, David and Eguíluz-Gracia, Ibon and Meyer, Rosan and Roberts, Graham and Roth-Walter, Franziska and Santos, Alexandra F and Skypala, Isabel and Smith, Peter K and Sokolowska, Milena and Torres, Maria J and Vassilopoulou, Emilia and Walter, Jens and O'Mahony, Liam},
  journal = {Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology},
  keywords = {evisap},
  month = {aug},
  number = 8,
  pages = {e70145--e70145},
  title = {Protocol: Scoping review of the association between complementary feeding, growth, and immune health in infants and toddlers-An EAACI guideline paper},
  volume = 36,
  year = 2025
  }
  

  %0 Journal Article
  %1 venter2025protocol
  %A Venter, Carina
  %A Alonso-Coello, Pablo
  %A Beltran, Jessica
  %A Bracchiglione, Javier
  %A Fernandez-Saenz, Karina
  %A Riera, Pau
  %A Solà, Ivan
  %A Arasi, Stefania
  %A Berni Canani, Roberto
  %A Fleischer, David
  %A Eguíluz-Gracia, Ibon
  %A Meyer, Rosan
  %A Roberts, Graham
  %A Roth-Walter, Franziska
  %A Santos, Alexandra F
  %A Skypala, Isabel
  %A Smith, Peter K
  %A Sokolowska, Milena
  %A Torres, Maria J
  %A Vassilopoulou, Emilia
  %A Walter, Jens
  %A O'Mahony, Liam
  %C England
  %D 2025
  %J Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  %N 8
  %P e70145--e70145
  %R 10.1111/pai.70145
  %T Protocol: Scoping review of the association between complementary feeding, growth, and immune health in infants and toddlers-An EAACI guideline paper
  %U https://pubmed.ncbi.nlm.nih.gov/40747578
  %V 36
  %X The European Academy of Allergy and Clinical Immunology (EAACI) is currently developing guidelines on immunomodulation and nutrition. To inform these recommendations, a scoping review will be conducted to synthesize and map the available empirical evidence on how complementary feeding affects immune health in infants and toddlers to explore the association between complementary feeding during the first year of life and immune health outcomes in children up to 3 years of age. The scoping review will be conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analysis Scoping Review Extension for scoping reviews (PRISMA-ScR) guidelines. We have developed inclusion criteria using the PCC (Population, Concept and Context) format: the population will include healthy infants; the concept refers to specific factors related to introduction of complementary feeding; and the context will focus on studies conducted in settings representative of everyday nutrition and feeding practices for infants and toddlers. Evidence sources include systematic reviews. We will search in MEDLINE and Epistemonikos. Data will be extracted using a standardized form developed in REDCap, and the findings will be synthesized narratively. Only published literature will be included in this systematic review. Therefore, no ethical approval is required. The final review paper will be published in a peer-reviewed journal. OSF registration DOI: 10.17605/OSF.IO/T5F8.
  

• 
  1.

  Oliver LL, Peña MPA, Ricci-Cabello I. Deprescripción como estrategia de seguridad del paciente en el manejo de fármacos de tipo AINE, opioides, IBP y antiagregantes. Actualización en Medicina de Familia: AMF. 2025;21(10):606-19.

  BibTeXEndNoteBibSonomy

  @article{RN2,
  author = {Oliver, Lourdes Luzón and Peña, María Pilar Astier and Ricci-Cabello, Ignacio},
  journal = {Actualización en Medicina de Familia: AMF},
  keywords = {evisap},
  number = 10,
  pages = {606-619},
  title = {Deprescripción como estrategia de seguridad del paciente en el manejo de fármacos de tipo AINE, opioides, IBP y antiagregantes},
  type = {Journal Article},
  volume = 21,
  year = 2025
  }
  

  %0 Journal Article
  %1 RN2
  %A Oliver, Lourdes Luzón
  %A Peña, María Pilar Astier
  %A Ricci-Cabello, Ignacio
  %D 2025
  %J Actualización en Medicina de Familia: AMF
  %N 10
  %P 606-619
  %T Deprescripción como estrategia de seguridad del paciente en el manejo de fármacos de tipo AINE, opioides, IBP y antiagregantes
  %V 21
  

• 
  1.

  Benejam JMC, Herrera RB, Ricci-Cabello I. Uso inadecuado y riesgo de sobrediagnóstico en las pruebas de imagen en Atención Primaria. Actualización en Medicina de Familia: AMF. 2025;21(10):578-86.

  BibTeXEndNoteBibSonomy

  @article{RN3,
  author = {Benejam, Josep Maria Coll and Herrera, Rubén Blanco and Ricci-Cabello, Ignacio},
  journal = {Actualización en Medicina de Familia: AMF},
  keywords = {evisap},
  number = 10,
  pages = {578-586},
  title = {Uso inadecuado y riesgo de sobrediagnóstico en las pruebas de imagen en Atención Primaria},
  type = {Journal Article},
  volume = 21,
  year = 2025
  }
  

  %0 Journal Article
  %1 RN3
  %A Benejam, Josep Maria Coll
  %A Herrera, Rubén Blanco
  %A Ricci-Cabello, Ignacio
  %D 2025
  %J Actualización en Medicina de Familia: AMF
  %N 10
  %P 578-586
  %T Uso inadecuado y riesgo de sobrediagnóstico en las pruebas de imagen en Atención Primaria
  %V 21
  

• 
  1.

  Marques-Cruz M, Pinto F, Vieira RJ, Bognanni A, Perestrelo P, Gil-Mata S, Duarte VH, Barbosa JP, Cardoso-Fernandes A, Martinho-Dias D, Franco-Pego F, Germini F, Arienti C, Chu AWL, Riera-Serra P, Jemioło P, Rodrigues PP, Fonseca JA, Azevedo LF, Schünemann HJ, Cruz-Correia R, Jankin S, Sousa-Pinto B. Use of artificial intelligence to support the assessment of the methodological quality of systematic reviews. Journal of clinical epidemiology [Internet]. United States; 2025 Nov.;187:111944-. https://pubmed.ncbi.nlm.nih.gov/40865587

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  OBJECTIVES: Published systematic reviews display a heterogeneous methodological quality, which can impact decision-making. Large language models (LLMs) can support and make the assessment of the methodological quality of systematic reviews more efficient, aiding in the incorporation of their evidence in guideline recommendations. We aimed to develop an LLM-based tool for supporting the assessment of the methodological quality of systematic reviews. METHODS: We assessed the performance of 8 LLMs in evaluating the methodological quality of systematic reviews. In particular, we provided 100 systematic reviews for eight LLMs (five base models and three fine-tuned models) to evaluate their methodological quality based on a 27-item validated tool (Reported Methodological Quality (ReMarQ)). The fine-tuned models had been trained with a different sample of 300 manually assessed systematic reviews. We compared the answers provided by LLMs with those independently provided by human reviewers, computing the accuracy, kappa coefficient and F1-score for this comparison. RESULTS: The best performing LLM was a fine-tuned GPT-3.5 model (mean accuracy = 96.5% [95% CI = 89.9%-100%]; mean kappa coefficient = 0.90 [95% CI = 0.71-1.00]; mean F1-score = 0.91 [95% CI = 0.83-1.00]). This model displayed an accuracy >80% and a kappa coefficient >0.60 for all individual items. When we made this LLM assess 60 times the same set of systematic reviews, answers to 18 of 27 items were always consistent (ie, were always the same) and only 11% of assessed systematic reviews showed inconsistency. CONCLUSION: Overall, LLMs have the potential to accurately support the assessment of the methodological quality of systematic reviews based on a validated tool comprising dichotomous items.

  @article{marquescruz2025artificial,
  abstract = {OBJECTIVES: Published systematic reviews display a heterogeneous methodological quality, which can impact decision-making. Large language models (LLMs) can support and make the assessment of the methodological quality of systematic reviews more efficient, aiding in the incorporation of their evidence in guideline recommendations. We aimed to develop an LLM-based tool for supporting the assessment of the methodological quality of systematic reviews. METHODS: We assessed the performance of 8 LLMs in evaluating the methodological quality of systematic reviews. In particular, we provided 100 systematic reviews for eight LLMs (five base models and three fine-tuned models) to evaluate their methodological quality based on a 27-item validated tool (Reported Methodological Quality (ReMarQ)). The fine-tuned models had been trained with a different sample of 300 manually assessed systematic reviews. We compared the answers provided by LLMs with those independently provided by human reviewers, computing the accuracy, kappa coefficient and F1-score for this comparison. RESULTS: The best performing LLM was a fine-tuned GPT-3.5 model (mean accuracy = 96.5% [95% CI = 89.9%-100%]; mean kappa coefficient = 0.90 [95% CI = 0.71-1.00]; mean F1-score = 0.91 [95% CI = 0.83-1.00]). This model displayed an accuracy >80% and a kappa coefficient >0.60 for all individual items. When we made this LLM assess 60 times the same set of systematic reviews, answers to 18 of 27 items were always consistent (ie, were always the same) and only 11% of assessed systematic reviews showed inconsistency. CONCLUSION: Overall, LLMs have the potential to accurately support the assessment of the methodological quality of systematic reviews based on a validated tool comprising dichotomous items.},
  address = {United States},
  author = {Marques-Cruz, Manuel and Pinto, Filipe and Vieira, Rafael José and Bognanni, Antonio and Perestrelo, Paula and Gil-Mata, Sara and Duarte, Vítor Henrique and Barbosa, José Pedro and Cardoso-Fernandes, António and Martinho-Dias, Daniel and Franco-Pego, Francisco and Germini, Federico and Arienti, Chiara and Chu, Alexandro W L and Riera-Serra, Pau and Jemioło, Paweł and Rodrigues, Pedro Pereira and Fonseca, João A and Azevedo, Luís Filipe and Schünemann, Holger J and Cruz-Correia, Ricardo and Jankin, Slava and Sousa-Pinto, Bernardo},
  journal = {Journal of clinical epidemiology},
  keywords = {evisap},
  month = {nov},
  pages = {111944--111944},
  title = {Use of artificial intelligence to support the assessment of the methodological quality of systematic reviews},
  volume = 187,
  year = 2025
  }
  

  %0 Journal Article
  %1 marquescruz2025artificial
  %A Marques-Cruz, Manuel
  %A Pinto, Filipe
  %A Vieira, Rafael José
  %A Bognanni, Antonio
  %A Perestrelo, Paula
  %A Gil-Mata, Sara
  %A Duarte, Vítor Henrique
  %A Barbosa, José Pedro
  %A Cardoso-Fernandes, António
  %A Martinho-Dias, Daniel
  %A Franco-Pego, Francisco
  %A Germini, Federico
  %A Arienti, Chiara
  %A Chu, Alexandro W L
  %A Riera-Serra, Pau
  %A Jemioło, Paweł
  %A Rodrigues, Pedro Pereira
  %A Fonseca, João A
  %A Azevedo, Luís Filipe
  %A Schünemann, Holger J
  %A Cruz-Correia, Ricardo
  %A Jankin, Slava
  %A Sousa-Pinto, Bernardo
  %C United States
  %D 2025
  %J Journal of clinical epidemiology
  %P 111944--111944
  %R 10.1016/j.jclinepi.2025.111944
  %T Use of artificial intelligence to support the assessment of the methodological quality of systematic reviews
  %U https://pubmed.ncbi.nlm.nih.gov/40865587
  %V 187
  %X OBJECTIVES: Published systematic reviews display a heterogeneous methodological quality, which can impact decision-making. Large language models (LLMs) can support and make the assessment of the methodological quality of systematic reviews more efficient, aiding in the incorporation of their evidence in guideline recommendations. We aimed to develop an LLM-based tool for supporting the assessment of the methodological quality of systematic reviews. METHODS: We assessed the performance of 8 LLMs in evaluating the methodological quality of systematic reviews. In particular, we provided 100 systematic reviews for eight LLMs (five base models and three fine-tuned models) to evaluate their methodological quality based on a 27-item validated tool (Reported Methodological Quality (ReMarQ)). The fine-tuned models had been trained with a different sample of 300 manually assessed systematic reviews. We compared the answers provided by LLMs with those independently provided by human reviewers, computing the accuracy, kappa coefficient and F1-score for this comparison. RESULTS: The best performing LLM was a fine-tuned GPT-3.5 model (mean accuracy = 96.5% [95% CI = 89.9%-100%]; mean kappa coefficient = 0.90 [95% CI = 0.71-1.00]; mean F1-score = 0.91 [95% CI = 0.83-1.00]). This model displayed an accuracy >80% and a kappa coefficient >0.60 for all individual items. When we made this LLM assess 60 times the same set of systematic reviews, answers to 18 of 27 items were always consistent (ie, were always the same) and only 11% of assessed systematic reviews showed inconsistency. CONCLUSION: Overall, LLMs have the potential to accurately support the assessment of the methodological quality of systematic reviews based on a validated tool comprising dichotomous items.
  

• 
  1.

  Mira-Martínez S, Malih N, Angullo-Martínez E, Zamanillo-Campos R, Yañez AM, Bennasar-Veny M, Gómez-Juanes R, Konieczna J, Jiménez R, Serrano-Ripoll MJ, Fiol deRoque MA, Leiva A, Galmes-Panades AM, Miralles-Xamena J, Vidal-Thomàs MC, Gómez-Cobo C, Gervilla E, Oña-Gil JI, Ricci-Cabello I. A Multifaceted Digital Intervention for the Prevention of Type 2 Diabetes Mellitus in Primary Care (PREDIABETEXT): Cluster Randomized Trial. Journal of medical Internet research [Internet]. Canada; 2025 Oct.;27:e70981-e70981. https://pubmed.ncbi.nlm.nih.gov/41067715

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUND: The diabetes epidemic continues to surge worldwide, demanding urgent and innovative solutions. Digital health interventions, particularly those targeting behavior change, hold promise due to their affordability and scalability. However, research in this field remains in its early stages. OBJECTIVE: This study aimed to evaluate the effectiveness of PREDIABETEXT (Prediabetes Text Message Digital Intervention for the Prevention of Type 2 Diabetes Mellitus), a digital health intervention, in reducing glycated hemoglobin (HbA(1c)) and in improving secondary clinical, physiological, and behavioral outcomes. METHODS: We conducted a 6-month, 3-arm, pragmatic cluster randomized clinical trial. We recruited patients with prediabetes (HbA(1c) levels between 6% and 6.4% in the previous 3 months or 2 consecutive fasting plasma glucose measurements of 110-125 mg/dL) registered at primary care centers in the Balearic Islands, Spain. The PREDIABETEXT intervention consisted of 3 personalized SMS text messages per week aimed at supporting lifestyle behavior changes and online training for their primary health care professionals. A total of 58 professionals (clusters) from 16 centers participated in the study and were randomized (1:1:1) to intervention group A (patient SMS text messaging), intervention group B (patient SMS text messaging+health care professional web-based training), or the control group (usual care). Following the 6-month intervention period, we conducted individual qualitative interviews with 8 patients and 7 health care professionals to evaluate their experiences with the intervention in terms of utility, satisfaction, and implementation barriers. RESULTS: In total, 58 health care professionals (clusters) were included, allocated to the control group (n=20, 34%; 119/365, 32.6% patients), intervention group A (SMS text messaging only; n=18, 31%; 106/365, 29% patients), and intervention group B (SMS text messaging+training; n=20, 34%; 140/365, 38.4% patients). The mean age of the patients was 59.79 (SD 9.75) years, and 54.5% (199/365) were female. The results of the intention-to-treat analysis at the 6-month time point showed that intervention A led to a small, nonsignificant reduction in HbA(1c) levels compared to the control group (β=-0.05, 95% CI -0.21 to 0.10; P=.50), whereas intervention B showed a similar nonsignificant reduction (β=-0.04, 95% CI -0.12 to 0.10; P=.56). No substantial differences were observed in the remaining secondary outcomes. Interviews revealed positive feedback from patients, who appreciated the intervention's dietary messages and their frequency and practicality. Participants suggested enhancements such as increased personalization, links to recipes, and nursing follow-ups. Health care professionals valued the online training but highlighted time constraints, suggesting shorter or blended formats to improve accessibility. CONCLUSIONS: While PREDIABETEXT did not significantly improve HbA(1c) levels, it demonstrated potential benefits for patient engagement. Further studies involving more intensive interventions are warranted to confirm the clinical impact on diabetes prevention. TRIAL REGISTRATION: ClinicalTrials.gov NCT05110625; https://www.clinicaltrials.gov/study/NCT05110625. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.3390/ijerph192214706.

  @article{miramartinez2025multifaceted,
  abstract = {BACKGROUND: The diabetes epidemic continues to surge worldwide, demanding urgent and innovative solutions. Digital health interventions, particularly those targeting behavior change, hold promise due to their affordability and scalability. However, research in this field remains in its early stages. OBJECTIVE: This study aimed to evaluate the effectiveness of PREDIABETEXT (Prediabetes Text Message Digital Intervention for the Prevention of Type 2 Diabetes Mellitus), a digital health intervention, in reducing glycated hemoglobin (HbA(1c)) and in improving secondary clinical, physiological, and behavioral outcomes. METHODS: We conducted a 6-month, 3-arm, pragmatic cluster randomized clinical trial. We recruited patients with prediabetes (HbA(1c) levels between 6% and 6.4% in the previous 3 months or 2 consecutive fasting plasma glucose measurements of 110-125 mg/dL) registered at primary care centers in the Balearic Islands, Spain. The PREDIABETEXT intervention consisted of 3 personalized SMS text messages per week aimed at supporting lifestyle behavior changes and online training for their primary health care professionals. A total of 58 professionals (clusters) from 16 centers participated in the study and were randomized (1:1:1) to intervention group A (patient SMS text messaging), intervention group B (patient SMS text messaging+health care professional web-based training), or the control group (usual care). Following the 6-month intervention period, we conducted individual qualitative interviews with 8 patients and 7 health care professionals to evaluate their experiences with the intervention in terms of utility, satisfaction, and implementation barriers. RESULTS: In total, 58 health care professionals (clusters) were included, allocated to the control group (n=20, 34%; 119/365, 32.6% patients), intervention group A (SMS text messaging only; n=18, 31%; 106/365, 29% patients), and intervention group B (SMS text messaging+training; n=20, 34%; 140/365, 38.4% patients). The mean age of the patients was 59.79 (SD 9.75) years, and 54.5% (199/365) were female. The results of the intention-to-treat analysis at the 6-month time point showed that intervention A led to a small, nonsignificant reduction in HbA(1c) levels compared to the control group (β=-0.05, 95% CI -0.21 to 0.10; P=.50), whereas intervention B showed a similar nonsignificant reduction (β=-0.04, 95% CI -0.12 to 0.10; P=.56). No substantial differences were observed in the remaining secondary outcomes. Interviews revealed positive feedback from patients, who appreciated the intervention's dietary messages and their frequency and practicality. Participants suggested enhancements such as increased personalization, links to recipes, and nursing follow-ups. Health care professionals valued the online training but highlighted time constraints, suggesting shorter or blended formats to improve accessibility. CONCLUSIONS: While PREDIABETEXT did not significantly improve HbA(1c) levels, it demonstrated potential benefits for patient engagement. Further studies involving more intensive interventions are warranted to confirm the clinical impact on diabetes prevention. TRIAL REGISTRATION: ClinicalTrials.gov NCT05110625; https://www.clinicaltrials.gov/study/NCT05110625. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.3390/ijerph192214706.},
  address = {Canada},
  author = {Mira-Martínez, Sofía and Malih, Narges and Angullo-Martínez, Escarlata and Zamanillo-Campos, Rocío and Yañez, Aina M and Bennasar-Veny, Miquel and Gómez-Juanes, Rocío and Konieczna, Jadwiga and Jiménez, Rafael and Serrano-Ripoll, Maria J and Fiol deRoque, Maria Antonia and Leiva, Alfonso and Galmes-Panades, Aina M and Miralles-Xamena, Jerónima and Vidal-Thomàs, Maria Clara and Gómez-Cobo, Cristina and Gervilla, Elena and Oña-Gil, José Iván and Ricci-Cabello, Ignacio},
  journal = {Journal of medical Internet research},
  keywords = {evisap},
  month = {oct},
  pages = {e70981--e70981},
  title = {A Multifaceted Digital Intervention for the Prevention of Type 2 Diabetes Mellitus in Primary Care (PREDIABETEXT): Cluster Randomized Trial},
  volume = 27,
  year = 2025
  }
  

  %0 Journal Article
  %1 miramartinez2025multifaceted
  %A Mira-Martínez, Sofía
  %A Malih, Narges
  %A Angullo-Martínez, Escarlata
  %A Zamanillo-Campos, Rocío
  %A Yañez, Aina M
  %A Bennasar-Veny, Miquel
  %A Gómez-Juanes, Rocío
  %A Konieczna, Jadwiga
  %A Jiménez, Rafael
  %A Serrano-Ripoll, Maria J
  %A Fiol deRoque, Maria Antonia
  %A Leiva, Alfonso
  %A Galmes-Panades, Aina M
  %A Miralles-Xamena, Jerónima
  %A Vidal-Thomàs, Maria Clara
  %A Gómez-Cobo, Cristina
  %A Gervilla, Elena
  %A Oña-Gil, José Iván
  %A Ricci-Cabello, Ignacio
  %C Canada
  %D 2025
  %J Journal of medical Internet research
  %P e70981--e70981
  %R 10.2196/70981
  %T A Multifaceted Digital Intervention for the Prevention of Type 2 Diabetes Mellitus in Primary Care (PREDIABETEXT): Cluster Randomized Trial
  %U https://pubmed.ncbi.nlm.nih.gov/41067715
  %V 27
  %X BACKGROUND: The diabetes epidemic continues to surge worldwide, demanding urgent and innovative solutions. Digital health interventions, particularly those targeting behavior change, hold promise due to their affordability and scalability. However, research in this field remains in its early stages. OBJECTIVE: This study aimed to evaluate the effectiveness of PREDIABETEXT (Prediabetes Text Message Digital Intervention for the Prevention of Type 2 Diabetes Mellitus), a digital health intervention, in reducing glycated hemoglobin (HbA(1c)) and in improving secondary clinical, physiological, and behavioral outcomes. METHODS: We conducted a 6-month, 3-arm, pragmatic cluster randomized clinical trial. We recruited patients with prediabetes (HbA(1c) levels between 6% and 6.4% in the previous 3 months or 2 consecutive fasting plasma glucose measurements of 110-125 mg/dL) registered at primary care centers in the Balearic Islands, Spain. The PREDIABETEXT intervention consisted of 3 personalized SMS text messages per week aimed at supporting lifestyle behavior changes and online training for their primary health care professionals. A total of 58 professionals (clusters) from 16 centers participated in the study and were randomized (1:1:1) to intervention group A (patient SMS text messaging), intervention group B (patient SMS text messaging+health care professional web-based training), or the control group (usual care). Following the 6-month intervention period, we conducted individual qualitative interviews with 8 patients and 7 health care professionals to evaluate their experiences with the intervention in terms of utility, satisfaction, and implementation barriers. RESULTS: In total, 58 health care professionals (clusters) were included, allocated to the control group (n=20, 34%; 119/365, 32.6% patients), intervention group A (SMS text messaging only; n=18, 31%; 106/365, 29% patients), and intervention group B (SMS text messaging+training; n=20, 34%; 140/365, 38.4% patients). The mean age of the patients was 59.79 (SD 9.75) years, and 54.5% (199/365) were female. The results of the intention-to-treat analysis at the 6-month time point showed that intervention A led to a small, nonsignificant reduction in HbA(1c) levels compared to the control group (β=-0.05, 95% CI -0.21 to 0.10; P=.50), whereas intervention B showed a similar nonsignificant reduction (β=-0.04, 95% CI -0.12 to 0.10; P=.56). No substantial differences were observed in the remaining secondary outcomes. Interviews revealed positive feedback from patients, who appreciated the intervention's dietary messages and their frequency and practicality. Participants suggested enhancements such as increased personalization, links to recipes, and nursing follow-ups. Health care professionals valued the online training but highlighted time constraints, suggesting shorter or blended formats to improve accessibility. CONCLUSIONS: While PREDIABETEXT did not significantly improve HbA(1c) levels, it demonstrated potential benefits for patient engagement. Further studies involving more intensive interventions are warranted to confirm the clinical impact on diabetes prevention. TRIAL REGISTRATION: ClinicalTrials.gov NCT05110625; https://www.clinicaltrials.gov/study/NCT05110625. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.3390/ijerph192214706.
  

• 
  1.

  Navarra-Ventura G, Coronado-Simsic V, Riera-Serra P, Castro A, García-Toro M, Roca M, Gili M. Associations between unhealthy lifestyle and depression: Cross-sectional results from the Spanish National Health Survey. Spanish journal of psychiatry and mental health [Internet]. Spain; 2025;18(3):191-8. https://pubmed.ncbi.nlm.nih.gov/38591831

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: Depression usually worsens lifestyle habits, but previous evidence also suggests that an unhealthy lifestyle (UL) increases the risk of depression. Many studies have analyzed the association between lifestyle and depression in several nationally representative samples, but none have done so in the Spanish adult population. Our aim was to examine the associations between UL habits and depression in Spain. MATERIALS AND METHODS: Analysis of cross-sectional data from the latest National Health Survey published in 2018 (N=23,089). Data on depression and 4 lifestyle factors (diet, physical exercise, smoking, and alcohol consumption) were used. These factors were combined into an UL index ranging from 0 (healthiest lifestyle) to 4 (unhealthiest lifestyle). The prevalence of depression at different levels of the UL index, and the association between depression and both the cumulative UL index and the 4 UL factors was analyzed using parametric and non-parametric tests. RESULTS: Sedentarism was the most prevalent UL factor, followed by unhealthy diet, smoking and high-risk alcohol consumption. Having ≥1 UL factors was associated with a higher prevalence of depression compared to having 0 UL factors (2.5% vs. ≥5.2%), regardless of the cumulative number UL factors (1, 2, 3 or 4). Being physically inactive (OR=1.6) and a smoker (OR=1.3) increased the likelihood of depression. Being a high-risk wine drinker (OR=0.26) decreased the likelihood of depression. Dietary intake was not significant. CONCLUSIONS: The prevalence of depression changes depending on several modifiable lifestyle factors. Policy makers should therefore spare no resources in promoting strategies to encourage healthy lifestyles and prevent the acquisition of UL habits.

  @article{navarraventura2025associations,
  abstract = {INTRODUCTION: Depression usually worsens lifestyle habits, but previous evidence also suggests that an unhealthy lifestyle (UL) increases the risk of depression. Many studies have analyzed the association between lifestyle and depression in several nationally representative samples, but none have done so in the Spanish adult population. Our aim was to examine the associations between UL habits and depression in Spain. MATERIALS AND METHODS: Analysis of cross-sectional data from the latest National Health Survey published in 2018 (N=23,089). Data on depression and 4 lifestyle factors (diet, physical exercise, smoking, and alcohol consumption) were used. These factors were combined into an UL index ranging from 0 (healthiest lifestyle) to 4 (unhealthiest lifestyle). The prevalence of depression at different levels of the UL index, and the association between depression and both the cumulative UL index and the 4 UL factors was analyzed using parametric and non-parametric tests. RESULTS: Sedentarism was the most prevalent UL factor, followed by unhealthy diet, smoking and high-risk alcohol consumption. Having ≥1 UL factors was associated with a higher prevalence of depression compared to having 0 UL factors (2.5% vs. ≥5.2%), regardless of the cumulative number UL factors (1, 2, 3 or 4). Being physically inactive (OR=1.6) and a smoker (OR=1.3) increased the likelihood of depression. Being a high-risk wine drinker (OR=0.26) decreased the likelihood of depression. Dietary intake was not significant. CONCLUSIONS: The prevalence of depression changes depending on several modifiable lifestyle factors. Policy makers should therefore spare no resources in promoting strategies to encourage healthy lifestyles and prevent the acquisition of UL habits.},
  address = {Spain},
  author = {Navarra-Ventura, Guillem and Coronado-Simsic, Victoria and Riera-Serra, Pau and Castro, Adoración and García-Toro, Mauro and Roca, Miquel and Gili, Margalida},
  journal = {Spanish journal of psychiatry and mental health},
  keywords = {evisap},
  number = 3,
  pages = {191--198},
  title = {Associations between unhealthy lifestyle and depression: Cross-sectional results from the Spanish National Health Survey},
  volume = 18,
  year = 2025
  }
  

  %0 Journal Article
  %1 navarraventura2025associations
  %A Navarra-Ventura, Guillem
  %A Coronado-Simsic, Victoria
  %A Riera-Serra, Pau
  %A Castro, Adoración
  %A García-Toro, Mauro
  %A Roca, Miquel
  %A Gili, Margalida
  %C Spain
  %D 2025
  %J Spanish journal of psychiatry and mental health
  %N 3
  %P 191--198
  %R 10.1016/j.sjpmh.2023.08.001
  %T Associations between unhealthy lifestyle and depression: Cross-sectional results from the Spanish National Health Survey
  %U https://pubmed.ncbi.nlm.nih.gov/38591831
  %V 18
  %X INTRODUCTION: Depression usually worsens lifestyle habits, but previous evidence also suggests that an unhealthy lifestyle (UL) increases the risk of depression. Many studies have analyzed the association between lifestyle and depression in several nationally representative samples, but none have done so in the Spanish adult population. Our aim was to examine the associations between UL habits and depression in Spain. MATERIALS AND METHODS: Analysis of cross-sectional data from the latest National Health Survey published in 2018 (N=23,089). Data on depression and 4 lifestyle factors (diet, physical exercise, smoking, and alcohol consumption) were used. These factors were combined into an UL index ranging from 0 (healthiest lifestyle) to 4 (unhealthiest lifestyle). The prevalence of depression at different levels of the UL index, and the association between depression and both the cumulative UL index and the 4 UL factors was analyzed using parametric and non-parametric tests. RESULTS: Sedentarism was the most prevalent UL factor, followed by unhealthy diet, smoking and high-risk alcohol consumption. Having ≥1 UL factors was associated with a higher prevalence of depression compared to having 0 UL factors (2.5% vs. ≥5.2%), regardless of the cumulative number UL factors (1, 2, 3 or 4). Being physically inactive (OR=1.6) and a smoker (OR=1.3) increased the likelihood of depression. Being a high-risk wine drinker (OR=0.26) decreased the likelihood of depression. Dietary intake was not significant. CONCLUSIONS: The prevalence of depression changes depending on several modifiable lifestyle factors. Policy makers should therefore spare no resources in promoting strategies to encourage healthy lifestyles and prevent the acquisition of UL habits.
  

• 
  1.

  Marques-Cruz M, Pinto F, Vieira RJ, Bognanni A, Perestrelo P, Gil-Mata S, Duarte VH, Barbosa JP, Cardoso-Fernandes A, Martinho-Dias D, Franco-Pego F, Germini F, Arienti C, Chu AWL, Riera-Serra P, Jemioło P, Rodrigues PP, Fonseca JA, Azevedo LF, Schünemann HJ, Cruz-Correia R, Jankin S, Sousa-Pinto B. Use of artificial intelligence to support the assessment of the methodological quality of systematic reviews. Journal of clinical epidemiology [Internet]. United States; 2025 Aug.;:111944-. https://pubmed.ncbi.nlm.nih.gov/40865587

  AbstractURLBibTeXEndNoteDOIBibSonomy

  INTRODUCTION: Published systematic reviews display an heterogeneous methodological quality, which can impact decision-making. Large language models (LLMs) can support and make the assessment of the methodological quality of systematic reviews more efficient, aiding in the incorporation of their evidence in guideline recommendations. We aimed to develop a LLM-based tool for supporting the assessment of the methodological quality of systematic reviews. METHODS: We assessed the performance of eight large language models (LLMs) in evaluating the methodological quality of systematic reviews. In particular, we provided 100 systematic reviews for eight LLMs (five base models and three fine-tuned models) to evaluate their methodological quality based on a 27-item validated tool (ReMarQ). The fine-tuned models had been trained with a different sample of 300 manually assessed systematic reviews. We compared the answers provided by LLMs with those independently provided by human reviewers, computing the accuracy, kappa coefficient and F1-score for this comparison. RESULTS: The best performing LLM was a fine-tuned GPT-3.5 model (mean accuracy=96.5% [95%CI=89.9-100%]; mean kappa coefficient=0.90 [95%CI=0.71-1.00]; mean F1-score=0.91 [95%CI=0.83-1.00]). This model displayed an accuracy >80% and a kappa coefficient >0.60 for all individual items. When we made this LLM assess 60 times the same set of systematic reviews, answers to 18 of 27 items were always consistent (i.e., were always the same) and only 11% of assessed systematic reviews showed inconsistency. CONCLUSION: Overall, LLMs have the potential to accurately support the assessment of the methodological quality of systematic reviews based on a validated tool comprising dichotomous items.

  @article{marquescruz2025artificial,
  abstract = {INTRODUCTION: Published systematic reviews display an heterogeneous methodological quality, which can impact decision-making. Large language models (LLMs) can support and make the assessment of the methodological quality of systematic reviews more efficient, aiding in the incorporation of their evidence in guideline recommendations. We aimed to develop a LLM-based tool for supporting the assessment of the methodological quality of systematic reviews. METHODS: We assessed the performance of eight large language models (LLMs) in evaluating the methodological quality of systematic reviews. In particular, we provided 100 systematic reviews for eight LLMs (five base models and three fine-tuned models) to evaluate their methodological quality based on a 27-item validated tool (ReMarQ). The fine-tuned models had been trained with a different sample of 300 manually assessed systematic reviews. We compared the answers provided by LLMs with those independently provided by human reviewers, computing the accuracy, kappa coefficient and F1-score for this comparison. RESULTS: The best performing LLM was a fine-tuned GPT-3.5 model (mean accuracy=96.5% [95%CI=89.9-100%]; mean kappa coefficient=0.90 [95%CI=0.71-1.00]; mean F1-score=0.91 [95%CI=0.83-1.00]). This model displayed an accuracy >80% and a kappa coefficient >0.60 for all individual items. When we made this LLM assess 60 times the same set of systematic reviews, answers to 18 of 27 items were always consistent (i.e., were always the same) and only 11% of assessed systematic reviews showed inconsistency. CONCLUSION: Overall, LLMs have the potential to accurately support the assessment of the methodological quality of systematic reviews based on a validated tool comprising dichotomous items.},
  address = {United States},
  author = {Marques-Cruz, Manuel and Pinto, Filipe and Vieira, Rafael José and Bognanni, Antonio and Perestrelo, Paula and Gil-Mata, Sara and Duarte, Vítor Henrique and Barbosa, José Pedro and Cardoso-Fernandes, António and Martinho-Dias, Daniel and Franco-Pego, Francisco and Germini, Federico and Arienti, Chiara and Chu, Alexandro W L and Riera-Serra, Pau and Jemioło, Paweł and Rodrigues, Pedro Pereira and Fonseca, João A and Azevedo, Luís Filipe and Schünemann, Holger J and Cruz-Correia, Ricardo and Jankin, Slava and Sousa-Pinto, Bernardo},
  journal = {Journal of clinical epidemiology},
  keywords = {evisap},
  month = {aug},
  pages = {111944--111944},
  title = {Use of artificial intelligence to support the assessment of the methodological quality of systematic reviews},
  year = 2025
  }
  

  %0 Journal Article
  %1 marquescruz2025artificial
  %A Marques-Cruz, Manuel
  %A Pinto, Filipe
  %A Vieira, Rafael José
  %A Bognanni, Antonio
  %A Perestrelo, Paula
  %A Gil-Mata, Sara
  %A Duarte, Vítor Henrique
  %A Barbosa, José Pedro
  %A Cardoso-Fernandes, António
  %A Martinho-Dias, Daniel
  %A Franco-Pego, Francisco
  %A Germini, Federico
  %A Arienti, Chiara
  %A Chu, Alexandro W L
  %A Riera-Serra, Pau
  %A Jemioło, Paweł
  %A Rodrigues, Pedro Pereira
  %A Fonseca, João A
  %A Azevedo, Luís Filipe
  %A Schünemann, Holger J
  %A Cruz-Correia, Ricardo
  %A Jankin, Slava
  %A Sousa-Pinto, Bernardo
  %C United States
  %D 2025
  %J Journal of clinical epidemiology
  %P 111944--111944
  %R 10.1016/j.jclinepi.2025.111944
  %T Use of artificial intelligence to support the assessment of the methodological quality of systematic reviews
  %U https://pubmed.ncbi.nlm.nih.gov/40865587
  %X INTRODUCTION: Published systematic reviews display an heterogeneous methodological quality, which can impact decision-making. Large language models (LLMs) can support and make the assessment of the methodological quality of systematic reviews more efficient, aiding in the incorporation of their evidence in guideline recommendations. We aimed to develop a LLM-based tool for supporting the assessment of the methodological quality of systematic reviews. METHODS: We assessed the performance of eight large language models (LLMs) in evaluating the methodological quality of systematic reviews. In particular, we provided 100 systematic reviews for eight LLMs (five base models and three fine-tuned models) to evaluate their methodological quality based on a 27-item validated tool (ReMarQ). The fine-tuned models had been trained with a different sample of 300 manually assessed systematic reviews. We compared the answers provided by LLMs with those independently provided by human reviewers, computing the accuracy, kappa coefficient and F1-score for this comparison. RESULTS: The best performing LLM was a fine-tuned GPT-3.5 model (mean accuracy=96.5% [95%CI=89.9-100%]; mean kappa coefficient=0.90 [95%CI=0.71-1.00]; mean F1-score=0.91 [95%CI=0.83-1.00]). This model displayed an accuracy >80% and a kappa coefficient >0.60 for all individual items. When we made this LLM assess 60 times the same set of systematic reviews, answers to 18 of 27 items were always consistent (i.e., were always the same) and only 11% of assessed systematic reviews showed inconsistency. CONCLUSION: Overall, LLMs have the potential to accurately support the assessment of the methodological quality of systematic reviews based on a validated tool comprising dichotomous items.
  

• 
  1.

  Chaplin A, Prohens L, Wordsworth J, Obrador-Hevia A, Guillot M, Ricci-Cabello I, Romaguera D, Sesé A. Identifying the key components of a diet and lifestyle screener for people living with and beyond cancer: an e-Delphi study. BMJ open [Internet]. England; 2025 Aug.;15(8):e097084-e097084. https://pubmed.ncbi.nlm.nih.gov/40784779

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  OBJECTIVES: There are currently no validated screeners that evaluate diet and lifestyle of people living with and beyond cancer (PLWBC). The purpose of this study was to reach a consensus among an international expert panel on the essential items to include in this type of instrument. DESIGN: A scientific committee developed the initial list of items, which were presented to an expert panel in a two-round-modified electronic Delphi. Panellists were asked to rate the adequacy, relevance and feasibility of self-reporting each item. Qualitative assessments were encouraged. SETTING: Four countries (Spain, UK, USA and Portugal). PARTICIPANTS: Experts working in a cancer-related health profession or cancer-related research were recruited. MAIN OUTCOME MEASURES: Items were initially categorised into seven domains (body composition, physical activity, diet, alcohol, smoking, sleep and psychosocial distress). A content validity index per item (CVI-i) and a scale-level CVI (S-CVI) were calculated (acceptable≥0.78). All items with a CVI-i≥0.78 were submitted to a final consensus meeting. RESULTS: A total of 108 items were proposed to the panel. In Round 1, 77 items were accepted, 10 items were excluded and 6 new items were proposed. During Round 2, 4 items were accepted and 19 were excluded. Diet and alcohol were merged into one domain. The final consensus meeting decided on 61 items categorised into six domains (S-CVI:0.94): body composition, physical activity, diet and alcohol, smoking, sleep and psychosocial distress. CONCLUSIONS: We identified the main items to be considered when developing a screener to evaluate diet and lifestyle in PLWBC in a clinical setting, and the results obtained will guide the content of the screener in the following validation study.

  @article{chaplin2025identifying,
  abstract = {OBJECTIVES: There are currently no validated screeners that evaluate diet and lifestyle of people living with and beyond cancer (PLWBC). The purpose of this study was to reach a consensus among an international expert panel on the essential items to include in this type of instrument. DESIGN: A scientific committee developed the initial list of items, which were presented to an expert panel in a two-round-modified electronic Delphi. Panellists were asked to rate the adequacy, relevance and feasibility of self-reporting each item. Qualitative assessments were encouraged. SETTING: Four countries (Spain, UK, USA and Portugal). PARTICIPANTS: Experts working in a cancer-related health profession or cancer-related research were recruited. MAIN OUTCOME MEASURES: Items were initially categorised into seven domains (body composition, physical activity, diet, alcohol, smoking, sleep and psychosocial distress). A content validity index per item (CVI-i) and a scale-level CVI (S-CVI) were calculated (acceptable≥0.78). All items with a CVI-i≥0.78 were submitted to a final consensus meeting. RESULTS: A total of 108 items were proposed to the panel. In Round 1, 77 items were accepted, 10 items were excluded and 6 new items were proposed. During Round 2, 4 items were accepted and 19 were excluded. Diet and alcohol were merged into one domain. The final consensus meeting decided on 61 items categorised into six domains (S-CVI:0.94): body composition, physical activity, diet and alcohol, smoking, sleep and psychosocial distress. CONCLUSIONS: We identified the main items to be considered when developing a screener to evaluate diet and lifestyle in PLWBC in a clinical setting, and the results obtained will guide the content of the screener in the following validation study.},
  address = {England},
  author = {Chaplin, Alice and Prohens, Lara and Wordsworth, Janna and Obrador-Hevia, Antònia and Guillot, Monica and Ricci-Cabello, Ignacio and Romaguera, Dora and Sesé, Albert},
  journal = {BMJ open},
  keywords = {evisap},
  month = {aug},
  number = 8,
  pages = {e097084--e097084},
  title = {Identifying the key components of a diet and lifestyle screener for people living with and beyond cancer: an e-Delphi study},
  volume = 15,
  year = 2025
  }
  

  %0 Journal Article
  %1 chaplin2025identifying
  %A Chaplin, Alice
  %A Prohens, Lara
  %A Wordsworth, Janna
  %A Obrador-Hevia, Antònia
  %A Guillot, Monica
  %A Ricci-Cabello, Ignacio
  %A Romaguera, Dora
  %A Sesé, Albert
  %C England
  %D 2025
  %J BMJ open
  %N 8
  %P e097084--e097084
  %R 10.1136/bmjopen-2024-097084
  %T Identifying the key components of a diet and lifestyle screener for people living with and beyond cancer: an e-Delphi study
  %U https://pubmed.ncbi.nlm.nih.gov/40784779
  %V 15
  %X OBJECTIVES: There are currently no validated screeners that evaluate diet and lifestyle of people living with and beyond cancer (PLWBC). The purpose of this study was to reach a consensus among an international expert panel on the essential items to include in this type of instrument. DESIGN: A scientific committee developed the initial list of items, which were presented to an expert panel in a two-round-modified electronic Delphi. Panellists were asked to rate the adequacy, relevance and feasibility of self-reporting each item. Qualitative assessments were encouraged. SETTING: Four countries (Spain, UK, USA and Portugal). PARTICIPANTS: Experts working in a cancer-related health profession or cancer-related research were recruited. MAIN OUTCOME MEASURES: Items were initially categorised into seven domains (body composition, physical activity, diet, alcohol, smoking, sleep and psychosocial distress). A content validity index per item (CVI-i) and a scale-level CVI (S-CVI) were calculated (acceptable≥0.78). All items with a CVI-i≥0.78 were submitted to a final consensus meeting. RESULTS: A total of 108 items were proposed to the panel. In Round 1, 77 items were accepted, 10 items were excluded and 6 new items were proposed. During Round 2, 4 items were accepted and 19 were excluded. Diet and alcohol were merged into one domain. The final consensus meeting decided on 61 items categorised into six domains (S-CVI:0.94): body composition, physical activity, diet and alcohol, smoking, sleep and psychosocial distress. CONCLUSIONS: We identified the main items to be considered when developing a screener to evaluate diet and lifestyle in PLWBC in a clinical setting, and the results obtained will guide the content of the screener in the following validation study.
  

• 
  1.

  García Samuelsson M, Tárraga López PJ, López-González Ángel A, Paublini H, Martínez-Almoyna Rifá E, Ramírez-Manent JI. Assessment of the Risk of Insulin Resistance in Workers Classified as Metabolically Healthy Obese. Nutrients [Internet]. Switzerland; 2025 Apr.;17(8):1345-. https://pubmed.ncbi.nlm.nih.gov/40284209

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Introduction and Objectives: Obesity constitutes a significant public health concern and is frequently linked to metabolic dysfunctions, particularly insulin resistance (IR). Nevertheless, a subset of obese individuals, referred to as metabolically healthy obese (MHO), do not exhibit overt metabolic abnormalities. The present study aims to assess the risk of developing IR among MHO workers and to explore the determinants contributing to this risk. Methods: This cross-sectional investigation utilized data from a cohort of 68,884 obese workers across multiple occupational sectors in Spain. The classification of participants as MHO was based on the number of metabolic syndrome components, in accordance with the criteria established by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). Anthropometric, clinical, and biochemical parameters-including body mass index (BMI), waist circumference, lipid profile, glycemic levels, and blood pressure-were systematically assessed. The likelihood of developing IR was estimated through various validated risk assessment models. Results: The analysis indicates that, despite having a relatively favorable metabolic profile, individuals classified as MHO also show signs of metabolic deterioration, such as an increased risk of insulin resistance. Key risk factors such as physical inactivity, low adherence to the Mediterranean diet, and socioeconomic disparities were identified as significant contributors to the transition from the MHO phenotype to a metabolically unhealthy state. Logistic regression analyses corroborated that insufficient physical activity and suboptimal dietary habits were strongly associated with an elevated risk of IR. Conclusions: The findings underscore the dynamic and potentially transient nature of the MHO phenotype, emphasizing the necessity of proactive monitoring and early preventive strategies. Encouraging physical activity, promoting adherence to a nutritionally balanced diet, and implementing workplace health initiatives emerge as critical measures to attenuate the risk of IR and metabolic deterioration in MHO individuals. Future longitudinal studies are warranted to enhance risk stratification and to formulate tailored preventive interventions.

  @article{garciasamuelsson2025assessment,
  abstract = {Introduction and Objectives: Obesity constitutes a significant public health concern and is frequently linked to metabolic dysfunctions, particularly insulin resistance (IR). Nevertheless, a subset of obese individuals, referred to as metabolically healthy obese (MHO), do not exhibit overt metabolic abnormalities. The present study aims to assess the risk of developing IR among MHO workers and to explore the determinants contributing to this risk. Methods: This cross-sectional investigation utilized data from a cohort of 68,884 obese workers across multiple occupational sectors in Spain. The classification of participants as MHO was based on the number of metabolic syndrome components, in accordance with the criteria established by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). Anthropometric, clinical, and biochemical parameters-including body mass index (BMI), waist circumference, lipid profile, glycemic levels, and blood pressure-were systematically assessed. The likelihood of developing IR was estimated through various validated risk assessment models. Results: The analysis indicates that, despite having a relatively favorable metabolic profile, individuals classified as MHO also show signs of metabolic deterioration, such as an increased risk of insulin resistance. Key risk factors such as physical inactivity, low adherence to the Mediterranean diet, and socioeconomic disparities were identified as significant contributors to the transition from the MHO phenotype to a metabolically unhealthy state. Logistic regression analyses corroborated that insufficient physical activity and suboptimal dietary habits were strongly associated with an elevated risk of IR. Conclusions: The findings underscore the dynamic and potentially transient nature of the MHO phenotype, emphasizing the necessity of proactive monitoring and early preventive strategies. Encouraging physical activity, promoting adherence to a nutritionally balanced diet, and implementing workplace health initiatives emerge as critical measures to attenuate the risk of IR and metabolic deterioration in MHO individuals. Future longitudinal studies are warranted to enhance risk stratification and to formulate tailored preventive interventions.},
  address = {Switzerland},
  author = {García Samuelsson, Miguel and Tárraga López, Pedro Juan and López-González, Ángel Arturo and Paublini, Hernán and Martínez-Almoyna Rifá, Emilio and Ramírez-Manent, José Ignacio},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {apr},
  number = 8,
  pages = {1345--},
  title = {Assessment of the Risk of Insulin Resistance in Workers Classified as Metabolically Healthy Obese},
  volume = 17,
  year = 2025
  }
  

  %0 Journal Article
  %1 garciasamuelsson2025assessment
  %A García Samuelsson, Miguel
  %A Tárraga López, Pedro Juan
  %A López-González, Ángel Arturo
  %A Paublini, Hernán
  %A Martínez-Almoyna Rifá, Emilio
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Nutrients
  %N 8
  %P 1345--
  %R 10.3390/nu17081345
  %T Assessment of the Risk of Insulin Resistance in Workers Classified as Metabolically Healthy Obese
  %U https://pubmed.ncbi.nlm.nih.gov/40284209
  %V 17
  %X Introduction and Objectives: Obesity constitutes a significant public health concern and is frequently linked to metabolic dysfunctions, particularly insulin resistance (IR). Nevertheless, a subset of obese individuals, referred to as metabolically healthy obese (MHO), do not exhibit overt metabolic abnormalities. The present study aims to assess the risk of developing IR among MHO workers and to explore the determinants contributing to this risk. Methods: This cross-sectional investigation utilized data from a cohort of 68,884 obese workers across multiple occupational sectors in Spain. The classification of participants as MHO was based on the number of metabolic syndrome components, in accordance with the criteria established by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). Anthropometric, clinical, and biochemical parameters-including body mass index (BMI), waist circumference, lipid profile, glycemic levels, and blood pressure-were systematically assessed. The likelihood of developing IR was estimated through various validated risk assessment models. Results: The analysis indicates that, despite having a relatively favorable metabolic profile, individuals classified as MHO also show signs of metabolic deterioration, such as an increased risk of insulin resistance. Key risk factors such as physical inactivity, low adherence to the Mediterranean diet, and socioeconomic disparities were identified as significant contributors to the transition from the MHO phenotype to a metabolically unhealthy state. Logistic regression analyses corroborated that insufficient physical activity and suboptimal dietary habits were strongly associated with an elevated risk of IR. Conclusions: The findings underscore the dynamic and potentially transient nature of the MHO phenotype, emphasizing the necessity of proactive monitoring and early preventive strategies. Encouraging physical activity, promoting adherence to a nutritionally balanced diet, and implementing workplace health initiatives emerge as critical measures to attenuate the risk of IR and metabolic deterioration in MHO individuals. Future longitudinal studies are warranted to enhance risk stratification and to formulate tailored preventive interventions.
  

• 
  1.

  Arias-Alonso L, Barragán-Brun N, Elizondo-Alzola U, Boldu-Minguell A, Rocha-Calderón CA, Niño-de Guzmán E, Santandreu FM, Quesada-Carrasco F, Ricci-Cabello I, Gorrotxategi-Gorrotxategi PJ, de la Poza-Abad M, Mas-Dalmau G, Gibert-Agulló A, González-Lama J, Alonso-Coello P. Development and assessment of an online communication skills course to optimise antibiotic prescribing for children in primary care. BMC primary care [Internet]. England; 2025 Aug.;26(1):247-. https://pubmed.ncbi.nlm.nih.gov/40775754

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Antibiotic overprescription is a complex global problem that contributes to antibacterial resistance. Enhancing professionals' communication skills is one of the most promising interventions for optimising antibiotic prescription in respiratory tract infections in children. METHODS: We developed a communication skills course for primary care paediatricians, paediatric nurses and community pharmacists. We conducted: 1) A scoping review, 2) brainstorming and selection of themes, 3) design of content, 4) user testing, through a survey and semi-structured interviews. A multidisciplinary advisory group gave feedback throughout the design and development process. We conducted a descriptive analysis of the survey results, and we used a predefined analytical framework for qualitative content. RESULTS: The course comprised four modules with nineteen themes, which included communication theoretical content, clinical cases, complementary reading, videos, and a glossary. It also included a forum and webinars, after each module. Sixteen users completed several themes and a survey, and eight were interviewed. They rated a mean of 4 or higher (5-point scale), across most of the domains evaluated. The videos received the highest rating (4.81; SD = 0.39). Suggestions for improvement included incorporating a workshop, and featuring more representation of other professionals. The majority of professionals (93%) expressed interest in completing the course. CONCLUSION: We developed a comprehensive, evidence-based online communication skills training course to optimise antibiotic prescribing in paediatric primary care. Integrating key communication strategies and insights from a scoping review, the course equips healthcare professionals with practical tools to enhance shared decision-making and antimicrobial stewardship. TRIAL REGISTRATION: Not applicable.

  @article{ariasalonso2025development,
  abstract = {BACKGROUND: Antibiotic overprescription is a complex global problem that contributes to antibacterial resistance. Enhancing professionals' communication skills is one of the most promising interventions for optimising antibiotic prescription in respiratory tract infections in children. METHODS: We developed a communication skills course for primary care paediatricians, paediatric nurses and community pharmacists. We conducted: 1) A scoping review, 2) brainstorming and selection of themes, 3) design of content, 4) user testing, through a survey and semi-structured interviews. A multidisciplinary advisory group gave feedback throughout the design and development process. We conducted a descriptive analysis of the survey results, and we used a predefined analytical framework for qualitative content. RESULTS: The course comprised four modules with nineteen themes, which included communication theoretical content, clinical cases, complementary reading, videos, and a glossary. It also included a forum and webinars, after each module. Sixteen users completed several themes and a survey, and eight were interviewed. They rated a mean of 4 or higher (5-point scale), across most of the domains evaluated. The videos received the highest rating (4.81; SD = 0.39). Suggestions for improvement included incorporating a workshop, and featuring more representation of other professionals. The majority of professionals (93%) expressed interest in completing the course. CONCLUSION: We developed a comprehensive, evidence-based online communication skills training course to optimise antibiotic prescribing in paediatric primary care. Integrating key communication strategies and insights from a scoping review, the course equips healthcare professionals with practical tools to enhance shared decision-making and antimicrobial stewardship. TRIAL REGISTRATION: Not applicable.},
  address = {England},
  author = {Arias-Alonso, Lucía and Barragán-Brun, Nieves and Elizondo-Alzola, Usue and Boldu-Minguell, Andrea and Rocha-Calderón, Claudio Alfonso and Niño-de Guzmán, Ena and Santandreu, Francisca María and Quesada-Carrasco, Fermín and Ricci-Cabello, Ignacio and Gorrotxategi-Gorrotxategi, Pedro Jesús and de la Poza-Abad, Mariam and Mas-Dalmau, Gemma and Gibert-Agulló, Anna and González-Lama, Jesús and Alonso-Coello, Pablo},
  journal = {BMC primary care},
  keywords = {evisap},
  month = {aug},
  number = 1,
  pages = {247--247},
  title = {Development and assessment of an online communication skills course to optimise antibiotic prescribing for children in primary care},
  volume = 26,
  year = 2025
  }
  

  %0 Journal Article
  %1 ariasalonso2025development
  %A Arias-Alonso, Lucía
  %A Barragán-Brun, Nieves
  %A Elizondo-Alzola, Usue
  %A Boldu-Minguell, Andrea
  %A Rocha-Calderón, Claudio Alfonso
  %A Niño-de Guzmán, Ena
  %A Santandreu, Francisca María
  %A Quesada-Carrasco, Fermín
  %A Ricci-Cabello, Ignacio
  %A Gorrotxategi-Gorrotxategi, Pedro Jesús
  %A de la Poza-Abad, Mariam
  %A Mas-Dalmau, Gemma
  %A Gibert-Agulló, Anna
  %A González-Lama, Jesús
  %A Alonso-Coello, Pablo
  %C England
  %D 2025
  %J BMC primary care
  %N 1
  %P 247--247
  %R 10.1186/s12875-025-02919-6
  %T Development and assessment of an online communication skills course to optimise antibiotic prescribing for children in primary care
  %U https://pubmed.ncbi.nlm.nih.gov/40775754
  %V 26
  %X BACKGROUND: Antibiotic overprescription is a complex global problem that contributes to antibacterial resistance. Enhancing professionals' communication skills is one of the most promising interventions for optimising antibiotic prescription in respiratory tract infections in children. METHODS: We developed a communication skills course for primary care paediatricians, paediatric nurses and community pharmacists. We conducted: 1) A scoping review, 2) brainstorming and selection of themes, 3) design of content, 4) user testing, through a survey and semi-structured interviews. A multidisciplinary advisory group gave feedback throughout the design and development process. We conducted a descriptive analysis of the survey results, and we used a predefined analytical framework for qualitative content. RESULTS: The course comprised four modules with nineteen themes, which included communication theoretical content, clinical cases, complementary reading, videos, and a glossary. It also included a forum and webinars, after each module. Sixteen users completed several themes and a survey, and eight were interviewed. They rated a mean of 4 or higher (5-point scale), across most of the domains evaluated. The videos received the highest rating (4.81; SD = 0.39). Suggestions for improvement included incorporating a workshop, and featuring more representation of other professionals. The majority of professionals (93%) expressed interest in completing the course. CONCLUSION: We developed a comprehensive, evidence-based online communication skills training course to optimise antibiotic prescribing in paediatric primary care. Integrating key communication strategies and insights from a scoping review, the course equips healthcare professionals with practical tools to enhance shared decision-making and antimicrobial stewardship. TRIAL REGISTRATION: Not applicable.
  

• 
  1.

  Navarra-Ventura G, Riera-Serra P, Castro A, Montaño JJ, Roca M, Gili M. Longitudinal associations between melancholic depression and executive function in adult patients with major depressive disorder: a 12-month follow-up study. Psychiatry research [Internet]. Ireland; 2025 Jul.;351:116636-. https://pubmed.ncbi.nlm.nih.gov/40651192

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Major depressive disorder (MDD) is often associated with deficits in executive function, but the long-term cognitive impact of specific depressive subtypes, in particular melancholic depression (MelD), is underexplored. This is the first prospective study aimed at exploring longitudinal associations between MelD and executive function in adult patients with MDD. This is a secondary analysis using data from a larger project with assessments at baseline, 6 and 12 months. MelD was identified using an algorithm derived from a subset of eight items from the Inventory of Depressive Symptomatology-Self Rated, which provides a standardized framework for the identification of this specific depressive subtype. Executive function was assessed using the Cambridge Neuropsychological Test Automated Battery. Longitudinal associations between MelD and executive function, including a global domain, four subdomains (working memory, planning, response inhibition and decision-making), and eight individual variables used to calculate the composite scores of the five (sub)domains, were analyzed using linear mixed-effects models adjusted for demographic and clinical variables and psychomotor speed. One hundred and five patients (20.95 % MelD) were analyzed at baseline, 73 (17.81 % MelD) at 6 months, and 61 (19.67 % MelD) at 12 months. MelD, older age and female sex were significantly associated with worse performance in the global executive function domain, in the working memory subdomain, and in four individual variables within the working memory, planning and decision-making subdomains, independent of other demographic and clinical variables and psychomotor speed. The findings highlight MelD as a distinct risk factor for worse long-term executive function in adult patients with MDD.

  @article{navarraventura2025longitudinal,
  abstract = {Major depressive disorder (MDD) is often associated with deficits in executive function, but the long-term cognitive impact of specific depressive subtypes, in particular melancholic depression (MelD), is underexplored. This is the first prospective study aimed at exploring longitudinal associations between MelD and executive function in adult patients with MDD. This is a secondary analysis using data from a larger project with assessments at baseline, 6 and 12 months. MelD was identified using an algorithm derived from a subset of eight items from the Inventory of Depressive Symptomatology-Self Rated, which provides a standardized framework for the identification of this specific depressive subtype. Executive function was assessed using the Cambridge Neuropsychological Test Automated Battery. Longitudinal associations between MelD and executive function, including a global domain, four subdomains (working memory, planning, response inhibition and decision-making), and eight individual variables used to calculate the composite scores of the five (sub)domains, were analyzed using linear mixed-effects models adjusted for demographic and clinical variables and psychomotor speed. One hundred and five patients (20.95 % MelD) were analyzed at baseline, 73 (17.81 % MelD) at 6 months, and 61 (19.67 % MelD) at 12 months. MelD, older age and female sex were significantly associated with worse performance in the global executive function domain, in the working memory subdomain, and in four individual variables within the working memory, planning and decision-making subdomains, independent of other demographic and clinical variables and psychomotor speed. The findings highlight MelD as a distinct risk factor for worse long-term executive function in adult patients with MDD.},
  address = {Ireland},
  author = {Navarra-Ventura, Guillem and Riera-Serra, Pau and Castro, Adoración and Montaño, Juan José and Roca, Miquel and Gili, Margalida},
  journal = {Psychiatry research},
  keywords = {evisap},
  month = {jul},
  pages = {116636--116636},
  title = {Longitudinal associations between melancholic depression and executive function in adult patients with major depressive disorder: a 12-month follow-up study},
  volume = 351,
  year = 2025
  }
  

  %0 Journal Article
  %1 navarraventura2025longitudinal
  %A Navarra-Ventura, Guillem
  %A Riera-Serra, Pau
  %A Castro, Adoración
  %A Montaño, Juan José
  %A Roca, Miquel
  %A Gili, Margalida
  %C Ireland
  %D 2025
  %J Psychiatry research
  %P 116636--116636
  %R 10.1016/j.psychres.2025.116636
  %T Longitudinal associations between melancholic depression and executive function in adult patients with major depressive disorder: a 12-month follow-up study
  %U https://pubmed.ncbi.nlm.nih.gov/40651192
  %V 351
  %X Major depressive disorder (MDD) is often associated with deficits in executive function, but the long-term cognitive impact of specific depressive subtypes, in particular melancholic depression (MelD), is underexplored. This is the first prospective study aimed at exploring longitudinal associations between MelD and executive function in adult patients with MDD. This is a secondary analysis using data from a larger project with assessments at baseline, 6 and 12 months. MelD was identified using an algorithm derived from a subset of eight items from the Inventory of Depressive Symptomatology-Self Rated, which provides a standardized framework for the identification of this specific depressive subtype. Executive function was assessed using the Cambridge Neuropsychological Test Automated Battery. Longitudinal associations between MelD and executive function, including a global domain, four subdomains (working memory, planning, response inhibition and decision-making), and eight individual variables used to calculate the composite scores of the five (sub)domains, were analyzed using linear mixed-effects models adjusted for demographic and clinical variables and psychomotor speed. One hundred and five patients (20.95 % MelD) were analyzed at baseline, 73 (17.81 % MelD) at 6 months, and 61 (19.67 % MelD) at 12 months. MelD, older age and female sex were significantly associated with worse performance in the global executive function domain, in the working memory subdomain, and in four individual variables within the working memory, planning and decision-making subdomains, independent of other demographic and clinical variables and psychomotor speed. The findings highlight MelD as a distinct risk factor for worse long-term executive function in adult patients with MDD.
  

• 
  1.

  Zamanillo-Campos R, Colom-Rossello M, Rodríguez-Calero MA, Martín MI, Planas T, Núñez-Jiménez C, Ramos M. Key components of effective non-pharmacological interventions for childhood obesity: a review considering social determinants of health. European journal of pediatrics [Internet]. Germany; 2025 Jun.;184(7):449-. https://pubmed.ncbi.nlm.nih.gov/40563002

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Childhood obesity, driven by an obesogenic environment, remains a public health priority. To review the effectiveness of non-pharmacological interventions for treating childhood obesity, with a focus on weight reduction and consideration of social determinants of health (SDOH). The review included randomized and quasi-experimental studies, published between August 2016 and December 2021, that evaluated the effectiveness of interventions aimed at reducing body weight in children aged 2 to 14 years with obesity. (PROSPERO ID: CRD42022301191). A total of 59 interventions were identified, showing wide variability in design, duration, components and settings. Most included physical activity (93%) and nutrition (81%), while fewer incorporated psychological support (46%) or digital tools (25%). Despite the diversity of approaches, 56% of the interventions were effective, particularly those implemented in healthcare or school settings, involving physical activity, and delivered by multidisciplinary teams. However, only six demonstrated sustained effects beyond 6 months. Risk of bias was high in over half of the studies, and only a small proportion (22%) reported participants' social characteristics such as family structure, race, or socioeconomic status. Importantly, very few interventions were designed or evaluated with explicit consideration of SDOH. CONCLUSION: Overall, effective interventions tended to target both children and parents, include multiple components-especially physical activity-and be delivered in accessible settings such as schools or primary care. Yet, the generalizability of findings is limited, as most studies involved children from relatively advantaged backgrounds. Future interventions should integrate SDOH in both design and evaluation to ensure equity and long-term effectiveness in diverse populations. WHAT IS KNOWN: • Childhood obesity remains a critical public health issue, heavily influenced by obesogenic environments and social determinants of health (SDOH). • Non-pharmacological interventions, particularly those incorporating physical activity and nutritional guidance, have been commonly used to address childhood obesity, though with varying degrees of success. WHAT IS NEW: • This review highlights that interventions delivered in healthcare or school settings by multidisciplinary teams, and involving both physical activity and parental engagement, show higher effectiveness in reducing childhood obesity. • The study identifies a significant gap in the integration of social determinants of health in both the design and evaluation of interventions, limiting their long-term impact and equity across diverse populations.

  @article{zamanillocampos2025components,
  abstract = {Childhood obesity, driven by an obesogenic environment, remains a public health priority. To review the effectiveness of non-pharmacological interventions for treating childhood obesity, with a focus on weight reduction and consideration of social determinants of health (SDOH). The review included randomized and quasi-experimental studies, published between August 2016 and December 2021, that evaluated the effectiveness of interventions aimed at reducing body weight in children aged 2 to 14 years with obesity. (PROSPERO ID: CRD42022301191). A total of 59 interventions were identified, showing wide variability in design, duration, components and settings. Most included physical activity (93%) and nutrition (81%), while fewer incorporated psychological support (46%) or digital tools (25%). Despite the diversity of approaches, 56% of the interventions were effective, particularly those implemented in healthcare or school settings, involving physical activity, and delivered by multidisciplinary teams. However, only six demonstrated sustained effects beyond 6 months. Risk of bias was high in over half of the studies, and only a small proportion (22%) reported participants' social characteristics such as family structure, race, or socioeconomic status. Importantly, very few interventions were designed or evaluated with explicit consideration of SDOH. CONCLUSION: Overall, effective interventions tended to target both children and parents, include multiple components-especially physical activity-and be delivered in accessible settings such as schools or primary care. Yet, the generalizability of findings is limited, as most studies involved children from relatively advantaged backgrounds. Future interventions should integrate SDOH in both design and evaluation to ensure equity and long-term effectiveness in diverse populations. WHAT IS KNOWN: • Childhood obesity remains a critical public health issue, heavily influenced by obesogenic environments and social determinants of health (SDOH). • Non-pharmacological interventions, particularly those incorporating physical activity and nutritional guidance, have been commonly used to address childhood obesity, though with varying degrees of success. WHAT IS NEW: • This review highlights that interventions delivered in healthcare or school settings by multidisciplinary teams, and involving both physical activity and parental engagement, show higher effectiveness in reducing childhood obesity. • The study identifies a significant gap in the integration of social determinants of health in both the design and evaluation of interventions, limiting their long-term impact and equity across diverse populations.},
  address = {Germany},
  author = {Zamanillo-Campos, R and Colom-Rossello, M and Rodríguez-Calero, M A and Martín, M I and Planas, T and Núñez-Jiménez, C and Ramos, M},
  journal = {European journal of pediatrics},
  keywords = {evisap},
  month = {jun},
  number = 7,
  pages = {449--449},
  title = {Key components of effective non-pharmacological interventions for childhood obesity: a review considering social determinants of health},
  volume = 184,
  year = 2025
  }
  

  %0 Journal Article
  %1 zamanillocampos2025components
  %A Zamanillo-Campos, R
  %A Colom-Rossello, M
  %A Rodríguez-Calero, M A
  %A Martín, M I
  %A Planas, T
  %A Núñez-Jiménez, C
  %A Ramos, M
  %C Germany
  %D 2025
  %J European journal of pediatrics
  %N 7
  %P 449--449
  %R 10.1007/s00431-025-06279-2
  %T Key components of effective non-pharmacological interventions for childhood obesity: a review considering social determinants of health
  %U https://pubmed.ncbi.nlm.nih.gov/40563002
  %V 184
  %X Childhood obesity, driven by an obesogenic environment, remains a public health priority. To review the effectiveness of non-pharmacological interventions for treating childhood obesity, with a focus on weight reduction and consideration of social determinants of health (SDOH). The review included randomized and quasi-experimental studies, published between August 2016 and December 2021, that evaluated the effectiveness of interventions aimed at reducing body weight in children aged 2 to 14 years with obesity. (PROSPERO ID: CRD42022301191). A total of 59 interventions were identified, showing wide variability in design, duration, components and settings. Most included physical activity (93%) and nutrition (81%), while fewer incorporated psychological support (46%) or digital tools (25%). Despite the diversity of approaches, 56% of the interventions were effective, particularly those implemented in healthcare or school settings, involving physical activity, and delivered by multidisciplinary teams. However, only six demonstrated sustained effects beyond 6 months. Risk of bias was high in over half of the studies, and only a small proportion (22%) reported participants' social characteristics such as family structure, race, or socioeconomic status. Importantly, very few interventions were designed or evaluated with explicit consideration of SDOH. CONCLUSION: Overall, effective interventions tended to target both children and parents, include multiple components-especially physical activity-and be delivered in accessible settings such as schools or primary care. Yet, the generalizability of findings is limited, as most studies involved children from relatively advantaged backgrounds. Future interventions should integrate SDOH in both design and evaluation to ensure equity and long-term effectiveness in diverse populations. WHAT IS KNOWN: • Childhood obesity remains a critical public health issue, heavily influenced by obesogenic environments and social determinants of health (SDOH). • Non-pharmacological interventions, particularly those incorporating physical activity and nutritional guidance, have been commonly used to address childhood obesity, though with varying degrees of success. WHAT IS NEW: • This review highlights that interventions delivered in healthcare or school settings by multidisciplinary teams, and involving both physical activity and parental engagement, show higher effectiveness in reducing childhood obesity. • The study identifies a significant gap in the integration of social determinants of health in both the design and evaluation of interventions, limiting their long-term impact and equity across diverse populations.
  

• 
  1.

  Bennasar-Veny M, Abbate M, Colom-Rosselló M, Capitán-Moyano L, Hernández-Bermúdez IC, Ricci-Cabello I, Yañez AM, Fernandez ME, investigators A. Impact of an adapted diabetes prevention program in a spanish primary care setting: protocol for a type II hybrid effectiveness-implementation cluster-randomized trial (ALADIM). Implementation science : IS [Internet]. England; 2025 Jun.;20(1):27-. https://pubmed.ncbi.nlm.nih.gov/40457444

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Type 2 diabetes (T2D) is a global health concern affecting 10.5% of the adult population and is projected to rise significantly in the coming decades. Lifestyle modification programs, such as the Diabetes Prevention Program (DPP), can effectively reduce T2D risk among individuals with prediabetes. However, their implementation in real-world healthcare settings remains poor, particularly in Spain, where T2D prevalence is the highest in Europe. The ALADIM study aims to evaluate the effectiveness and implementation of an adapted DPP in Spanish Primary Care Centers (PCCs). The primary effectiveness outcome is weight, the co-primary implementation outcome is implementation fidelity. We will also assess the effect of DPP implementation on overall prediabetes management within the PCCs (spillover) by measuring the percentage of people with prediabetes receiving lifestyle advice. METHODS: The ALADIM trial is a hybrid type II effectiveness-implementation cluster-randomized controlled trial involving 10 PCCs of Mallorca (Balearic Islands, Spain). PCCs will be randomized to the intervention (5 PCCs) or control (5 PCCs) group in a 1:1 ratio. The intervention group will receive training and materials to implement and deliver the adapted DPP over 12 months. The control group will continue providing usual care. The DPP will be culturally adapted using the Intervention Mapping-ADAPT (IM-ADAPT) approach. The implementation strategy will be designed using Implementation Mapping. Measures of effectiveness will be assessed at the participant level at baseline, 6 and 12 months during the intervention period, and 18 months after baseline. Implementation outcomes will be assessed at the PCC level at multiple time-points throughout the study period. Spillover will be assessed at PCC level at months -1, 6 and 18. An intention-to-treat analysis will assess effectiveness and spillover effect using generalized estimating equations. Implementation outcomes will be evaluated using a mixed-methods approach. DISCUSSION: The ALADIM study has the potential to address the gap between research and practice by employing implementation science for evaluation, adaptation and implementation of an evidence-based diabetes intervention. The findings will contribute to the development of a sustainable and scalable implementation strategy for T2D prevention, with potential implications for policy and practice at regional and national levels. TRIAL REGISTRATION: ClinicalTrials.gov, NCT06871059. Registered 10 March 2025, https://clinicaltrials.gov/study/NCT06871059.

  @article{bennasarveny2025impact,
  abstract = {BACKGROUND: Type 2 diabetes (T2D) is a global health concern affecting 10.5% of the adult population and is projected to rise significantly in the coming decades. Lifestyle modification programs, such as the Diabetes Prevention Program (DPP), can effectively reduce T2D risk among individuals with prediabetes. However, their implementation in real-world healthcare settings remains poor, particularly in Spain, where T2D prevalence is the highest in Europe. The ALADIM study aims to evaluate the effectiveness and implementation of an adapted DPP in Spanish Primary Care Centers (PCCs). The primary effectiveness outcome is weight, the co-primary implementation outcome is implementation fidelity. We will also assess the effect of DPP implementation on overall prediabetes management within the PCCs (spillover) by measuring the percentage of people with prediabetes receiving lifestyle advice. METHODS: The ALADIM trial is a hybrid type II effectiveness-implementation cluster-randomized controlled trial involving 10 PCCs of Mallorca (Balearic Islands, Spain). PCCs will be randomized to the intervention (5 PCCs) or control (5 PCCs) group in a 1:1 ratio. The intervention group will receive training and materials to implement and deliver the adapted DPP over 12 months. The control group will continue providing usual care. The DPP will be culturally adapted using the Intervention Mapping-ADAPT (IM-ADAPT) approach. The implementation strategy will be designed using Implementation Mapping. Measures of effectiveness will be assessed at the participant level at baseline, 6 and 12 months during the intervention period, and 18 months after baseline. Implementation outcomes will be assessed at the PCC level at multiple time-points throughout the study period. Spillover will be assessed at PCC level at months -1, 6 and 18. An intention-to-treat analysis will assess effectiveness and spillover effect using generalized estimating equations. Implementation outcomes will be evaluated using a mixed-methods approach. DISCUSSION: The ALADIM study has the potential to address the gap between research and practice by employing implementation science for evaluation, adaptation and implementation of an evidence-based diabetes intervention. The findings will contribute to the development of a sustainable and scalable implementation strategy for T2D prevention, with potential implications for policy and practice at regional and national levels. TRIAL REGISTRATION: ClinicalTrials.gov, NCT06871059. Registered 10 March 2025, https://clinicaltrials.gov/study/NCT06871059.},
  address = {England},
  author = {Bennasar-Veny, Miquel and Abbate, Manuela and Colom-Rosselló, Miquel and Capitán-Moyano, Laura and Hernández-Bermúdez, Ivonne C and Ricci-Cabello, Ignacio and Yañez, Aina M and Fernandez, Maria E and investigators, ALADIM},
  journal = {Implementation science : IS},
  keywords = {evisap},
  month = {jun},
  number = 1,
  pages = {27--27},
  title = {Impact of an adapted diabetes prevention program in a spanish primary care setting: protocol for a type II hybrid effectiveness-implementation cluster-randomized trial (ALADIM)},
  volume = 20,
  year = 2025
  }
  

  %0 Journal Article
  %1 bennasarveny2025impact
  %A Bennasar-Veny, Miquel
  %A Abbate, Manuela
  %A Colom-Rosselló, Miquel
  %A Capitán-Moyano, Laura
  %A Hernández-Bermúdez, Ivonne C
  %A Ricci-Cabello, Ignacio
  %A Yañez, Aina M
  %A Fernandez, Maria E
  %A investigators, ALADIM
  %C England
  %D 2025
  %J Implementation science : IS
  %N 1
  %P 27--27
  %R 10.1186/s13012-025-01438-3
  %T Impact of an adapted diabetes prevention program in a spanish primary care setting: protocol for a type II hybrid effectiveness-implementation cluster-randomized trial (ALADIM)
  %U https://pubmed.ncbi.nlm.nih.gov/40457444
  %V 20
  %X BACKGROUND: Type 2 diabetes (T2D) is a global health concern affecting 10.5% of the adult population and is projected to rise significantly in the coming decades. Lifestyle modification programs, such as the Diabetes Prevention Program (DPP), can effectively reduce T2D risk among individuals with prediabetes. However, their implementation in real-world healthcare settings remains poor, particularly in Spain, where T2D prevalence is the highest in Europe. The ALADIM study aims to evaluate the effectiveness and implementation of an adapted DPP in Spanish Primary Care Centers (PCCs). The primary effectiveness outcome is weight, the co-primary implementation outcome is implementation fidelity. We will also assess the effect of DPP implementation on overall prediabetes management within the PCCs (spillover) by measuring the percentage of people with prediabetes receiving lifestyle advice. METHODS: The ALADIM trial is a hybrid type II effectiveness-implementation cluster-randomized controlled trial involving 10 PCCs of Mallorca (Balearic Islands, Spain). PCCs will be randomized to the intervention (5 PCCs) or control (5 PCCs) group in a 1:1 ratio. The intervention group will receive training and materials to implement and deliver the adapted DPP over 12 months. The control group will continue providing usual care. The DPP will be culturally adapted using the Intervention Mapping-ADAPT (IM-ADAPT) approach. The implementation strategy will be designed using Implementation Mapping. Measures of effectiveness will be assessed at the participant level at baseline, 6 and 12 months during the intervention period, and 18 months after baseline. Implementation outcomes will be assessed at the PCC level at multiple time-points throughout the study period. Spillover will be assessed at PCC level at months -1, 6 and 18. An intention-to-treat analysis will assess effectiveness and spillover effect using generalized estimating equations. Implementation outcomes will be evaluated using a mixed-methods approach. DISCUSSION: The ALADIM study has the potential to address the gap between research and practice by employing implementation science for evaluation, adaptation and implementation of an evidence-based diabetes intervention. The findings will contribute to the development of a sustainable and scalable implementation strategy for T2D prevention, with potential implications for policy and practice at regional and national levels. TRIAL REGISTRATION: ClinicalTrials.gov, NCT06871059. Registered 10 March 2025, https://clinicaltrials.gov/study/NCT06871059.
  

• 
  1.

  Chaplin A, Wordsworth J, Prohens L, Obrador-Hevia A, Guillot M, Ricci-Cabello I, Sesé A, Romaguera D. Validation and pilot feasibility study of a novel screener to assess diet, lifestyle and mental health in people living with and beyond cancer: Study protocols. PloS one [Internet]. United States; 2025 Jun.;20(6):e0323671-e0323671. https://pubmed.ncbi.nlm.nih.gov/40472046

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND AND AIM: Current clinical care may not address behavioural and psychosocial elements which can influence quality of life (QoL) and recurrence risk of people living with and beyond cancer (PLWBC). There is a lack of validated tools to assess diet, lifestyle and mental health in PLWBC. We have developed a screener to identify individuals who may need further support beyond cancer recurrence. The aim is two-fold: 1) validate the screener in PLWBC; and 2) carry out a pilot feasibility study (PFS) to explore the impact of a lifestyle complex intervention (diet, physical activity and mental health components) on the QoL of PLWBC. METHODS: The study will be carried out at the University Hospital Son Espases (Spain) in PLWBC. A face validity study (n = 15) will assess construct interpretation, completion time, and acquiescence of the screener. For construct validity and reproducibility analysis (n = 100), participants will answer the screener together with validated diet, lifestyle, and mental health questionnaires for comparison. Body composition, physical activity, strength and cortisol levels will be assessed using validated instruments. All participants will answer the screener 7-10 days later for reproducibility analysis. Participants will then be randomized (1:1) to the Low Intervention (LI) or the High Intervention (HI) for the PFS study. LI will receive general advice regarding diet, lifestyle and mental health, and HI will receive individual and group sessions with specialised health professionals. Participants will be followed for three months. Primary outcomes include: 1) validity and reproducibility of the screener; and 2) feasibility of a complex intervention to improve QoL of PLWBC. Secondary outcomes include changes in screener answers and body composition. DISCUSSION: A validated screener which detects PLWBC's needs could be used in follow-up care plans. The PFS will inform on the recruitment of participants and identify potential shortfalls of the design and efficacy. TRIAL REGISTRATION: ClinicalTrials.gov NCT06582498.

  @article{chaplin2025validation,
  abstract = {BACKGROUND AND AIM: Current clinical care may not address behavioural and psychosocial elements which can influence quality of life (QoL) and recurrence risk of people living with and beyond cancer (PLWBC). There is a lack of validated tools to assess diet, lifestyle and mental health in PLWBC. We have developed a screener to identify individuals who may need further support beyond cancer recurrence. The aim is two-fold: 1) validate the screener in PLWBC; and 2) carry out a pilot feasibility study (PFS) to explore the impact of a lifestyle complex intervention (diet, physical activity and mental health components) on the QoL of PLWBC. METHODS: The study will be carried out at the University Hospital Son Espases (Spain) in PLWBC. A face validity study (n = 15) will assess construct interpretation, completion time, and acquiescence of the screener. For construct validity and reproducibility analysis (n = 100), participants will answer the screener together with validated diet, lifestyle, and mental health questionnaires for comparison. Body composition, physical activity, strength and cortisol levels will be assessed using validated instruments. All participants will answer the screener 7-10 days later for reproducibility analysis. Participants will then be randomized (1:1) to the Low Intervention (LI) or the High Intervention (HI) for the PFS study. LI will receive general advice regarding diet, lifestyle and mental health, and HI will receive individual and group sessions with specialised health professionals. Participants will be followed for three months. Primary outcomes include: 1) validity and reproducibility of the screener; and 2) feasibility of a complex intervention to improve QoL of PLWBC. Secondary outcomes include changes in screener answers and body composition. DISCUSSION: A validated screener which detects PLWBC's needs could be used in follow-up care plans. The PFS will inform on the recruitment of participants and identify potential shortfalls of the design and efficacy. TRIAL REGISTRATION: ClinicalTrials.gov NCT06582498.},
  address = {United States},
  author = {Chaplin, Alice and Wordsworth, Janna and Prohens, Lara and Obrador-Hevia, Antònia and Guillot, Monica and Ricci-Cabello, Ignacio and Sesé, Albert and Romaguera, Dora},
  journal = {PloS one},
  keywords = {evisap},
  month = {jun},
  number = 6,
  pages = {e0323671--e0323671},
  title = {Validation and pilot feasibility study of a novel screener to assess diet, lifestyle and mental health in people living with and beyond cancer: Study protocols},
  volume = 20,
  year = 2025
  }
  

  %0 Journal Article
  %1 chaplin2025validation
  %A Chaplin, Alice
  %A Wordsworth, Janna
  %A Prohens, Lara
  %A Obrador-Hevia, Antònia
  %A Guillot, Monica
  %A Ricci-Cabello, Ignacio
  %A Sesé, Albert
  %A Romaguera, Dora
  %C United States
  %D 2025
  %J PloS one
  %N 6
  %P e0323671--e0323671
  %R 10.1371/journal.pone.0323671
  %T Validation and pilot feasibility study of a novel screener to assess diet, lifestyle and mental health in people living with and beyond cancer: Study protocols
  %U https://pubmed.ncbi.nlm.nih.gov/40472046
  %V 20
  %X BACKGROUND AND AIM: Current clinical care may not address behavioural and psychosocial elements which can influence quality of life (QoL) and recurrence risk of people living with and beyond cancer (PLWBC). There is a lack of validated tools to assess diet, lifestyle and mental health in PLWBC. We have developed a screener to identify individuals who may need further support beyond cancer recurrence. The aim is two-fold: 1) validate the screener in PLWBC; and 2) carry out a pilot feasibility study (PFS) to explore the impact of a lifestyle complex intervention (diet, physical activity and mental health components) on the QoL of PLWBC. METHODS: The study will be carried out at the University Hospital Son Espases (Spain) in PLWBC. A face validity study (n = 15) will assess construct interpretation, completion time, and acquiescence of the screener. For construct validity and reproducibility analysis (n = 100), participants will answer the screener together with validated diet, lifestyle, and mental health questionnaires for comparison. Body composition, physical activity, strength and cortisol levels will be assessed using validated instruments. All participants will answer the screener 7-10 days later for reproducibility analysis. Participants will then be randomized (1:1) to the Low Intervention (LI) or the High Intervention (HI) for the PFS study. LI will receive general advice regarding diet, lifestyle and mental health, and HI will receive individual and group sessions with specialised health professionals. Participants will be followed for three months. Primary outcomes include: 1) validity and reproducibility of the screener; and 2) feasibility of a complex intervention to improve QoL of PLWBC. Secondary outcomes include changes in screener answers and body composition. DISCUSSION: A validated screener which detects PLWBC's needs could be used in follow-up care plans. The PFS will inform on the recruitment of participants and identify potential shortfalls of the design and efficacy. TRIAL REGISTRATION: ClinicalTrials.gov NCT06582498.
  

• 
  1.

  Marques-Cruz M, Perestrelo P, Chu AWL, Gil-Mata S, Riera-Serra P, Sousa-Pinto B. Comparison between two tools assessing the methodological quality of systematic reviews: ReMarQ and AMSTAR 2. Clinical and Public Health Guidelines [Internet]. 2025;2(2):e70021. https://onlinelibrary.wiley.com/doi/abs/10.1002/gin2.70021

  URLBibTeXEndNoteDOIBibSonomyDownload

  @article{RN64,
  author = {Marques-Cruz, Manuel and Perestrelo, Paula and Chu, Alexandro W. L. and Gil-Mata, Sara and Riera-Serra, Pau and Sousa-Pinto, Bernardo},
  journal = {Clinical and Public Health Guidelines},
  keywords = {evisap},
  number = 2,
  pages = {e70021},
  title = {Comparison between two tools assessing the methodological quality of systematic reviews: ReMarQ and AMSTAR 2},
  type = {Journal Article},
  volume = 2,
  year = 2025
  }
  

  %0 Journal Article
  %1 RN64
  %A Marques-Cruz, Manuel
  %A Perestrelo, Paula
  %A Chu, Alexandro W. L.
  %A Gil-Mata, Sara
  %A Riera-Serra, Pau
  %A Sousa-Pinto, Bernardo
  %D 2025
  %J Clinical and Public Health Guidelines
  %N 2
  %P e70021
  %R https://doi.org/10.1002/gin2.70021
  %T Comparison between two tools assessing the methodological quality of systematic reviews: ReMarQ and AMSTAR 2
  %U https://onlinelibrary.wiley.com/doi/abs/10.1002/gin2.70021
  %V 2
  

• 
  1.

  Obrador de Hevia J, López-González Ángel A, Ramírez-Manent JI, Paublini H, Tárraga López PJ, Martorell Sánchez C, Riutord-Sbert P. Association Between Alcohol Consumption, Other Healthy Habits and Sociodemographic Variables and the Values of Different Insulin Resistance Risk Scales in 139,634 Spanish Workers. Healthcare (Basel, Switzerland) [Internet]. Switzerland; 2025 Apr.;13(8):921-. https://pubmed.ncbi.nlm.nih.gov/40281870

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Background: Alcohol consumption is a major public health concern, influencing metabolic health and insulin resistance (IR). While moderate alcohol intake has been associated with potential metabolic benefits, excessive consumption is linked to IR and related disorders. This study examines the association between sociodemographic variables, health habits, and IR risk using validated metabolic indices. Methods: A dual-phase study was conducted, including a cross-sectional analysis of 139,634 Spanish workers and a retrospective longitudinal follow-up of 40,431 participants (2009-2019). Data on sociodemographic factors (age, sex and socioeconomic status) and health habits (smoking, alcohol consumption, diet and physical activity) were collected through standardized occupational health assessments. IR risk was assessed using the Triglyceride-Glucose Index (TyG), Metabolic Score for Insulin Resistance (METS-IR), and Single-Point Insulin Sensitivity Estimator (SPISE-IR). Binary logistic regression was used for statistical analysis. Results: Age, male sex, lower socioeconomic status, smoking, alcohol consumption, physical inactivity and low adherence to the Mediterranean diet were significantly associated with higher IR risk across all indices (p < 0.001). Alcohol consumption exhibited a dose-dependent relationship with IR, with excessive intake significantly increasing the risk of IR. Longitudinal data revealed a worsening IR profile over time, particularly among older, low-income and physically inactive individuals. Conclusions: Sociodemographic factors and lifestyle habits strongly influence IR. Preventive strategies focused on reducing alcohol consumption, smoking cessation and promoting physical activity and dietary improvements are essential to mitigate the risk of IR, especially in vulnerable populations. Further longitudinal studies are needed to establish causal relationships and refine intervention strategies.

  @article{obradordehevia2025association,
  abstract = {Background: Alcohol consumption is a major public health concern, influencing metabolic health and insulin resistance (IR). While moderate alcohol intake has been associated with potential metabolic benefits, excessive consumption is linked to IR and related disorders. This study examines the association between sociodemographic variables, health habits, and IR risk using validated metabolic indices. Methods: A dual-phase study was conducted, including a cross-sectional analysis of 139,634 Spanish workers and a retrospective longitudinal follow-up of 40,431 participants (2009-2019). Data on sociodemographic factors (age, sex and socioeconomic status) and health habits (smoking, alcohol consumption, diet and physical activity) were collected through standardized occupational health assessments. IR risk was assessed using the Triglyceride-Glucose Index (TyG), Metabolic Score for Insulin Resistance (METS-IR), and Single-Point Insulin Sensitivity Estimator (SPISE-IR). Binary logistic regression was used for statistical analysis. Results: Age, male sex, lower socioeconomic status, smoking, alcohol consumption, physical inactivity and low adherence to the Mediterranean diet were significantly associated with higher IR risk across all indices (p < 0.001). Alcohol consumption exhibited a dose-dependent relationship with IR, with excessive intake significantly increasing the risk of IR. Longitudinal data revealed a worsening IR profile over time, particularly among older, low-income and physically inactive individuals. Conclusions: Sociodemographic factors and lifestyle habits strongly influence IR. Preventive strategies focused on reducing alcohol consumption, smoking cessation and promoting physical activity and dietary improvements are essential to mitigate the risk of IR, especially in vulnerable populations. Further longitudinal studies are needed to establish causal relationships and refine intervention strategies.},
  address = {Switzerland},
  author = {Obrador de Hevia, Joan and López-González, Ángel Arturo and Ramírez-Manent, José Ignacio and Paublini, Hernán and Tárraga López, Pedro Juan and Martorell Sánchez, Cristina and Riutord-Sbert, Pere},
  journal = {Healthcare (Basel, Switzerland)},
  keywords = {grapp-caib},
  month = {apr},
  number = 8,
  pages = {921--},
  title = {Association Between Alcohol Consumption, Other Healthy Habits and Sociodemographic Variables and the Values of Different Insulin Resistance Risk Scales in 139,634 Spanish Workers},
  volume = 13,
  year = 2025
  }
  

  %0 Journal Article
  %1 obradordehevia2025association
  %A Obrador de Hevia, Joan
  %A López-González, Ángel Arturo
  %A Ramírez-Manent, José Ignacio
  %A Paublini, Hernán
  %A Tárraga López, Pedro Juan
  %A Martorell Sánchez, Cristina
  %A Riutord-Sbert, Pere
  %C Switzerland
  %D 2025
  %J Healthcare (Basel, Switzerland)
  %N 8
  %P 921--
  %R 10.3390/healthcare13080921
  %T Association Between Alcohol Consumption, Other Healthy Habits and Sociodemographic Variables and the Values of Different Insulin Resistance Risk Scales in 139,634 Spanish Workers
  %U https://pubmed.ncbi.nlm.nih.gov/40281870
  %V 13
  %X Background: Alcohol consumption is a major public health concern, influencing metabolic health and insulin resistance (IR). While moderate alcohol intake has been associated with potential metabolic benefits, excessive consumption is linked to IR and related disorders. This study examines the association between sociodemographic variables, health habits, and IR risk using validated metabolic indices. Methods: A dual-phase study was conducted, including a cross-sectional analysis of 139,634 Spanish workers and a retrospective longitudinal follow-up of 40,431 participants (2009-2019). Data on sociodemographic factors (age, sex and socioeconomic status) and health habits (smoking, alcohol consumption, diet and physical activity) were collected through standardized occupational health assessments. IR risk was assessed using the Triglyceride-Glucose Index (TyG), Metabolic Score for Insulin Resistance (METS-IR), and Single-Point Insulin Sensitivity Estimator (SPISE-IR). Binary logistic regression was used for statistical analysis. Results: Age, male sex, lower socioeconomic status, smoking, alcohol consumption, physical inactivity and low adherence to the Mediterranean diet were significantly associated with higher IR risk across all indices (p < 0.001). Alcohol consumption exhibited a dose-dependent relationship with IR, with excessive intake significantly increasing the risk of IR. Longitudinal data revealed a worsening IR profile over time, particularly among older, low-income and physically inactive individuals. Conclusions: Sociodemographic factors and lifestyle habits strongly influence IR. Preventive strategies focused on reducing alcohol consumption, smoking cessation and promoting physical activity and dietary improvements are essential to mitigate the risk of IR, especially in vulnerable populations. Further longitudinal studies are needed to establish causal relationships and refine intervention strategies.
  

• 
  1.

  Pang Y, Szuecs A, Ricci-Cabello I, Gangannagaripalli J, Goh LH, Leong FL, Zhou LF, Valderas JM. Patient and family engagement interventions in primary care patient safety: systematic review and meta-analysis of randomised controlled trials. The British journal of general practice : the journal of the Royal College of General Practitioners [Internet]. England; 2025 May;:BJGP.2024.0369-. https://pubmed.ncbi.nlm.nih.gov/40355248

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Engaging patients and families have been promoted as a key strategy for improving patient safety of health systems. However, evidence remains scarce on the effectiveness of this approach in primary care. AIM: To assess the combined effectiveness of primary care interventions in randomised controlled trials (RCTs) promoting patient and family engagement in patient safety. DESIGN AND SETTING: Systematic review and meta-analysis. METHODS: The review followed PRISMA and Cochrane guidelines. Five electronic databases (MEDLINE, CINAHL, Embase, Web of Science, CENTRAL) were searched from inception to 18 September 2024 with keywords in four blocks (patient and family engagement; patient safety; primary care; randomised controlled trial). Patient and family engagement levels were appraised. Where feasible and advisable, results were combined into meta-analyses. RESULTS: Of the 19 included records, 12 reported on completed RCTs. Only one intervention integrated patients/families into overall care safety (high engagement); six aimed at enhancing skills and tools (intermediate), and 12 infirmed patients/families how to engage and prompted them to do it (low). RCTs primarily targeted medication safety, with meta-analyses showing no significant effects on reducing adverse drug events (OR=0.83, 95%CI [0.70,1.08]) or improving medication appropriateness measured categorically (OR=0.92, 95%CI [0.76,1.13]) or continuously (MD=0.71, 95%CI [-0.10,1.52]). Overall risk of bias was low and certainty of evidence very low to moderate. CONCLUSION: Existing randomised controlled evidence on patient and family engagement in primary care remains inconclusive and limited in scope. Future interventions should include higher levels of engagement and address more diverse patient safety outcomes relevant for primary care.

  @article{pang2025patient,
  abstract = {BACKGROUND: Engaging patients and families have been promoted as a key strategy for improving patient safety of health systems. However, evidence remains scarce on the effectiveness of this approach in primary care. AIM: To assess the combined effectiveness of primary care interventions in randomised controlled trials (RCTs) promoting patient and family engagement in patient safety. DESIGN AND SETTING: Systematic review and meta-analysis. METHODS: The review followed PRISMA and Cochrane guidelines. Five electronic databases (MEDLINE, CINAHL, Embase, Web of Science, CENTRAL) were searched from inception to 18 September 2024 with keywords in four blocks (patient and family engagement; patient safety; primary care; randomised controlled trial). Patient and family engagement levels were appraised. Where feasible and advisable, results were combined into meta-analyses. RESULTS: Of the 19 included records, 12 reported on completed RCTs. Only one intervention integrated patients/families into overall care safety (high engagement); six aimed at enhancing skills and tools (intermediate), and 12 infirmed patients/families how to engage and prompted them to do it (low). RCTs primarily targeted medication safety, with meta-analyses showing no significant effects on reducing adverse drug events (OR=0.83, 95%CI [0.70,1.08]) or improving medication appropriateness measured categorically (OR=0.92, 95%CI [0.76,1.13]) or continuously (MD=0.71, 95%CI [-0.10,1.52]). Overall risk of bias was low and certainty of evidence very low to moderate. CONCLUSION: Existing randomised controlled evidence on patient and family engagement in primary care remains inconclusive and limited in scope. Future interventions should include higher levels of engagement and address more diverse patient safety outcomes relevant for primary care.},
  address = {England},
  author = {Pang, Yan and Szuecs, Anna and Ricci-Cabello, Ignacio and Gangannagaripalli, Jaheeda and Goh, Lay Hoon and Leong, Foon Leng and Zhou, Li Fan and Valderas, Jose Maria},
  journal = {The British journal of general practice : the journal of the Royal College of General Practitioners},
  keywords = {evisap},
  month = {may},
  pages = {BJGP.2024.0369--},
  title = {Patient and family engagement interventions in primary care patient safety: systematic review and meta-analysis of randomised controlled trials},
  year = 2025
  }
  

  %0 Journal Article
  %1 pang2025patient
  %A Pang, Yan
  %A Szuecs, Anna
  %A Ricci-Cabello, Ignacio
  %A Gangannagaripalli, Jaheeda
  %A Goh, Lay Hoon
  %A Leong, Foon Leng
  %A Zhou, Li Fan
  %A Valderas, Jose Maria
  %C England
  %D 2025
  %J The British journal of general practice : the journal of the Royal College of General Practitioners
  %P BJGP.2024.0369--
  %R 10.3399/BJGP.2024.0369
  %T Patient and family engagement interventions in primary care patient safety: systematic review and meta-analysis of randomised controlled trials
  %U https://pubmed.ncbi.nlm.nih.gov/40355248
  %X BACKGROUND: Engaging patients and families have been promoted as a key strategy for improving patient safety of health systems. However, evidence remains scarce on the effectiveness of this approach in primary care. AIM: To assess the combined effectiveness of primary care interventions in randomised controlled trials (RCTs) promoting patient and family engagement in patient safety. DESIGN AND SETTING: Systematic review and meta-analysis. METHODS: The review followed PRISMA and Cochrane guidelines. Five electronic databases (MEDLINE, CINAHL, Embase, Web of Science, CENTRAL) were searched from inception to 18 September 2024 with keywords in four blocks (patient and family engagement; patient safety; primary care; randomised controlled trial). Patient and family engagement levels were appraised. Where feasible and advisable, results were combined into meta-analyses. RESULTS: Of the 19 included records, 12 reported on completed RCTs. Only one intervention integrated patients/families into overall care safety (high engagement); six aimed at enhancing skills and tools (intermediate), and 12 infirmed patients/families how to engage and prompted them to do it (low). RCTs primarily targeted medication safety, with meta-analyses showing no significant effects on reducing adverse drug events (OR=0.83, 95%CI [0.70,1.08]) or improving medication appropriateness measured categorically (OR=0.92, 95%CI [0.76,1.13]) or continuously (MD=0.71, 95%CI [-0.10,1.52]). Overall risk of bias was low and certainty of evidence very low to moderate. CONCLUSION: Existing randomised controlled evidence on patient and family engagement in primary care remains inconclusive and limited in scope. Future interventions should include higher levels of engagement and address more diverse patient safety outcomes relevant for primary care.
  

• 
  1.

  Tárraga Marcos PJ, López-González Ángel A, Martínez-Almoyna Rifá E, Paublini Oliveira H, Martorell Sánchez C, Tárraga López PJ, Ramírez-Manent JI. The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study. Life (Basel, Switzerland) [Internet]. Switzerland; 2025 Jan.;15(1):81-. https://pubmed.ncbi.nlm.nih.gov/39860021

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Introduction: Metabolic syndrome (MetS) and hypertriglyceridemic waist (HTW) are two multifactorial pathological conditions that have been increasing in prevalence worldwide. The objective of this study was to evaluate how various sociodemographic variables and healthy habits are associated with the presence or absence of MetS and HTW. Methodology: This study employed a mixed-methods approach, consisting of a retrospective longitudinal study and a cross-sectional descriptive study, analyzing 44,939 healthcare workers with MS and HTW across four professional categories to evaluate the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet using three diagnostic criteria. Descriptive analysis included categorical and quantitative variables, which were assessed through frequencies, Student's t-test, chi-square, and binary logistic regression models. Logistic regression and Cohen's kappa were used to evaluate associations and concordances. Age, sex, and lack of physical activity showed the strongest associations with MetS (OR: 2.65-2.84). The results highlight the importance of physical activity and other factors in metabolic prevention. Results: Age, sex, and physical activity were the variables most strongly associated with MetS and HTW across the three evaluated diagnostic criteria. The odds ratios revealed significant values: age (9.07-13.71 for MetS and 13.42 for HTW), sex (2.82-3.31 for MetS and 3.72 for HTW), and physical activity (2.65-2.84 for MetS and 2.40 for HTW). Conclusions: The risk of developing MetS and HTW among healthcare personnel is influenced by lifestyle habits, sex, and age, with the highest ORs observed in nursing assistants and orderlies. Future research that delves deeper into the causal relationship between lifestyle factors and the severity of MetS and HTW in healthcare personnel will improve understanding and facilitate the development of preventive activities to reduce their incidence.

  @article{tarragamarcos2025prevalence,
  abstract = {Introduction: Metabolic syndrome (MetS) and hypertriglyceridemic waist (HTW) are two multifactorial pathological conditions that have been increasing in prevalence worldwide. The objective of this study was to evaluate how various sociodemographic variables and healthy habits are associated with the presence or absence of MetS and HTW. Methodology: This study employed a mixed-methods approach, consisting of a retrospective longitudinal study and a cross-sectional descriptive study, analyzing 44,939 healthcare workers with MS and HTW across four professional categories to evaluate the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet using three diagnostic criteria. Descriptive analysis included categorical and quantitative variables, which were assessed through frequencies, Student's t-test, chi-square, and binary logistic regression models. Logistic regression and Cohen's kappa were used to evaluate associations and concordances. Age, sex, and lack of physical activity showed the strongest associations with MetS (OR: 2.65-2.84). The results highlight the importance of physical activity and other factors in metabolic prevention. Results: Age, sex, and physical activity were the variables most strongly associated with MetS and HTW across the three evaluated diagnostic criteria. The odds ratios revealed significant values: age (9.07-13.71 for MetS and 13.42 for HTW), sex (2.82-3.31 for MetS and 3.72 for HTW), and physical activity (2.65-2.84 for MetS and 2.40 for HTW). Conclusions: The risk of developing MetS and HTW among healthcare personnel is influenced by lifestyle habits, sex, and age, with the highest ORs observed in nursing assistants and orderlies. Future research that delves deeper into the causal relationship between lifestyle factors and the severity of MetS and HTW in healthcare personnel will improve understanding and facilitate the development of preventive activities to reduce their incidence.},
  address = {Switzerland},
  author = {Tárraga Marcos, Pedro Javier and López-González, Ángel Arturo and Martínez-Almoyna Rifá, Emilio and Paublini Oliveira, Hernán and Martorell Sánchez, Cristina and Tárraga López, Pedro Juan and Ramírez-Manent, José Ignacio},
  journal = {Life (Basel, Switzerland)},
  keywords = {grapp-caib},
  month = {jan},
  number = 1,
  pages = {81--},
  title = {The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study},
  volume = 15,
  year = 2025
  }
  

  %0 Journal Article
  %1 tarragamarcos2025prevalence
  %A Tárraga Marcos, Pedro Javier
  %A López-González, Ángel Arturo
  %A Martínez-Almoyna Rifá, Emilio
  %A Paublini Oliveira, Hernán
  %A Martorell Sánchez, Cristina
  %A Tárraga López, Pedro Juan
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Life (Basel, Switzerland)
  %N 1
  %P 81--
  %R 10.3390/life15010081
  %T The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study
  %U https://pubmed.ncbi.nlm.nih.gov/39860021
  %V 15
  %X Introduction: Metabolic syndrome (MetS) and hypertriglyceridemic waist (HTW) are two multifactorial pathological conditions that have been increasing in prevalence worldwide. The objective of this study was to evaluate how various sociodemographic variables and healthy habits are associated with the presence or absence of MetS and HTW. Methodology: This study employed a mixed-methods approach, consisting of a retrospective longitudinal study and a cross-sectional descriptive study, analyzing 44,939 healthcare workers with MS and HTW across four professional categories to evaluate the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet using three diagnostic criteria. Descriptive analysis included categorical and quantitative variables, which were assessed through frequencies, Student's t-test, chi-square, and binary logistic regression models. Logistic regression and Cohen's kappa were used to evaluate associations and concordances. Age, sex, and lack of physical activity showed the strongest associations with MetS (OR: 2.65-2.84). The results highlight the importance of physical activity and other factors in metabolic prevention. Results: Age, sex, and physical activity were the variables most strongly associated with MetS and HTW across the three evaluated diagnostic criteria. The odds ratios revealed significant values: age (9.07-13.71 for MetS and 13.42 for HTW), sex (2.82-3.31 for MetS and 3.72 for HTW), and physical activity (2.65-2.84 for MetS and 2.40 for HTW). Conclusions: The risk of developing MetS and HTW among healthcare personnel is influenced by lifestyle habits, sex, and age, with the highest ORs observed in nursing assistants and orderlies. Future research that delves deeper into the causal relationship between lifestyle factors and the severity of MetS and HTW in healthcare personnel will improve understanding and facilitate the development of preventive activities to reduce their incidence.
  

• 
  1.

  Fiol deRoque MA, Valderas JM, Serrano-Ripoll MJ, Gens-Barbarà M, Martín-Luján F, Sánchez-Freire E, Montaño JJ, Mira-Martínez S, Pastor-Moreno G, Zamanillo-Campos R, Riera-Serra P, Ricci-Cabello I. Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial. BMC medicine [Internet]. England; 2025 Apr.;23(1):202-. https://pubmed.ncbi.nlm.nih.gov/40189506

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Patient safety, defined by the WHO as the absence of preventable harm, is a critical component of healthcare quality and poses a significant challenge globally. This study aimed to evaluate the effectiveness of SinergiAPS, a patient-centred audit and feedback intervention, in improving patient safety in primary healthcare (PHC) centres. METHODS: We conducted a 12-month cluster randomized controlled, multicentre trial. Fifty-nine PHC centres (1053 PHC professionals) in Spain were recruited and randomly allocated (1:1) to usual care or SinergiAPS intervention. The SinergiAPS intervention comprised: a bespoke feedback report with results from audits of patient safety based on the Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) questionnaire, administered to 75 patients/centre; a set of educational materials, and a structured template to record safety improvement plans. The primary outcome (at the PHC professional level) was patient safety culture (Medical Office Survey on Patient Safety Culture (MOSPSC) questionnaire). Secondary outcomes (at the centre level) were patient-reported safety (six PREOS-PC scales), and rate of avoidable hospital admissions. After a 12-month follow-up, we conducted 15 semi-structured interviews with PHC professionals to explore their perceptions of the intervention. RESULTS: During the 12-month follow-up, 10 of the 30 centres in the intervention group held action plan team meetings and eight registered 57 safety improvement action plans. The plans aimed to improve patient activation, address treatment-related incidents, enhance communication between patients and providers, and strengthen patient safety culture. At 12 months, no significant differences were observed in MOSPSC mean score (intervention: 3.60 [95% CI 3.55 to 3.64] vs. control: 3.64 [3.60 to 3.68]). Similarly, no differences were observed in the secondary outcomes, with both groups experiencing a decline in patient-reported safety and avoidable hospital admissions. The qualitative interviews evidenced that the onset of the COVID-19 pandemic 6-9 weeks after initiating the follow-up period severely limited PHC's capacity of developing and implementing safety improvement action plans, despite high levels of acceptability and perceived utility of the SinergiAPS intervention. CONCLUSIONS: In the context of the health emergency caused by the COVID-19 pandemic, SinergiAPS did not improve patient safety in Spanish PHC centres. TRIAL REGISTRATION: ClinicalTrials.gov (NCT03837912).

  @article{fiolderoque2025evaluating,
  abstract = {BACKGROUND: Patient safety, defined by the WHO as the absence of preventable harm, is a critical component of healthcare quality and poses a significant challenge globally. This study aimed to evaluate the effectiveness of SinergiAPS, a patient-centred audit and feedback intervention, in improving patient safety in primary healthcare (PHC) centres. METHODS: We conducted a 12-month cluster randomized controlled, multicentre trial. Fifty-nine PHC centres (1053 PHC professionals) in Spain were recruited and randomly allocated (1:1) to usual care or SinergiAPS intervention. The SinergiAPS intervention comprised: a bespoke feedback report with results from audits of patient safety based on the Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) questionnaire, administered to 75 patients/centre; a set of educational materials, and a structured template to record safety improvement plans. The primary outcome (at the PHC professional level) was patient safety culture (Medical Office Survey on Patient Safety Culture (MOSPSC) questionnaire). Secondary outcomes (at the centre level) were patient-reported safety (six PREOS-PC scales), and rate of avoidable hospital admissions. After a 12-month follow-up, we conducted 15 semi-structured interviews with PHC professionals to explore their perceptions of the intervention. RESULTS: During the 12-month follow-up, 10 of the 30 centres in the intervention group held action plan team meetings and eight registered 57 safety improvement action plans. The plans aimed to improve patient activation, address treatment-related incidents, enhance communication between patients and providers, and strengthen patient safety culture. At 12 months, no significant differences were observed in MOSPSC mean score (intervention: 3.60 [95% CI 3.55 to 3.64] vs. control: 3.64 [3.60 to 3.68]). Similarly, no differences were observed in the secondary outcomes, with both groups experiencing a decline in patient-reported safety and avoidable hospital admissions. The qualitative interviews evidenced that the onset of the COVID-19 pandemic 6-9 weeks after initiating the follow-up period severely limited PHC's capacity of developing and implementing safety improvement action plans, despite high levels of acceptability and perceived utility of the SinergiAPS intervention. CONCLUSIONS: In the context of the health emergency caused by the COVID-19 pandemic, SinergiAPS did not improve patient safety in Spanish PHC centres. TRIAL REGISTRATION: ClinicalTrials.gov (NCT03837912).},
  address = {England},
  author = {Fiol deRoque, Maria Antònia and Valderas, José María and Serrano-Ripoll, María Jesús and Gens-Barbarà, Montserrat and Martín-Luján, Francisco and Sánchez-Freire, Encarna and Montaño, Juan José and Mira-Martínez, Sofía and Pastor-Moreno, Guadalupe and Zamanillo-Campos, Rocío and Riera-Serra, Pau and Ricci-Cabello, Ignacio},
  journal = {BMC medicine},
  keywords = {evisap grapp-caib},
  month = {apr},
  number = 1,
  pages = {202--202},
  title = {Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial},
  volume = 23,
  year = 2025
  }
  

  %0 Journal Article
  %1 fiolderoque2025evaluating
  %A Fiol deRoque, Maria Antònia
  %A Valderas, José María
  %A Serrano-Ripoll, María Jesús
  %A Gens-Barbarà, Montserrat
  %A Martín-Luján, Francisco
  %A Sánchez-Freire, Encarna
  %A Montaño, Juan José
  %A Mira-Martínez, Sofía
  %A Pastor-Moreno, Guadalupe
  %A Zamanillo-Campos, Rocío
  %A Riera-Serra, Pau
  %A Ricci-Cabello, Ignacio
  %C England
  %D 2025
  %J BMC medicine
  %N 1
  %P 202--202
  %R 10.1186/s12916-025-04029-7
  %T Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial
  %U https://pubmed.ncbi.nlm.nih.gov/40189506
  %V 23
  %X BACKGROUND: Patient safety, defined by the WHO as the absence of preventable harm, is a critical component of healthcare quality and poses a significant challenge globally. This study aimed to evaluate the effectiveness of SinergiAPS, a patient-centred audit and feedback intervention, in improving patient safety in primary healthcare (PHC) centres. METHODS: We conducted a 12-month cluster randomized controlled, multicentre trial. Fifty-nine PHC centres (1053 PHC professionals) in Spain were recruited and randomly allocated (1:1) to usual care or SinergiAPS intervention. The SinergiAPS intervention comprised: a bespoke feedback report with results from audits of patient safety based on the Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) questionnaire, administered to 75 patients/centre; a set of educational materials, and a structured template to record safety improvement plans. The primary outcome (at the PHC professional level) was patient safety culture (Medical Office Survey on Patient Safety Culture (MOSPSC) questionnaire). Secondary outcomes (at the centre level) were patient-reported safety (six PREOS-PC scales), and rate of avoidable hospital admissions. After a 12-month follow-up, we conducted 15 semi-structured interviews with PHC professionals to explore their perceptions of the intervention. RESULTS: During the 12-month follow-up, 10 of the 30 centres in the intervention group held action plan team meetings and eight registered 57 safety improvement action plans. The plans aimed to improve patient activation, address treatment-related incidents, enhance communication between patients and providers, and strengthen patient safety culture. At 12 months, no significant differences were observed in MOSPSC mean score (intervention: 3.60 [95% CI 3.55 to 3.64] vs. control: 3.64 [3.60 to 3.68]). Similarly, no differences were observed in the secondary outcomes, with both groups experiencing a decline in patient-reported safety and avoidable hospital admissions. The qualitative interviews evidenced that the onset of the COVID-19 pandemic 6-9 weeks after initiating the follow-up period severely limited PHC's capacity of developing and implementing safety improvement action plans, despite high levels of acceptability and perceived utility of the SinergiAPS intervention. CONCLUSIONS: In the context of the health emergency caused by the COVID-19 pandemic, SinergiAPS did not improve patient safety in Spanish PHC centres. TRIAL REGISTRATION: ClinicalTrials.gov (NCT03837912).
  

• 
  1.

  Marcos PJT, López PJT, López-González Ángel A, Rifá EM-A, Oliveira HP, Sánchez CM, Ramírez-Manent JI. Estimation of Cardiovascular Risk Using SCORE2, REGICOR and Vascular Age Scales in Spanish Healthcare Workers: A Retrospective Longitudinal Study. Healthcare (Basel, Switzerland) [Internet]. Switzerland; 2025 Feb.;13(4):375-. https://pubmed.ncbi.nlm.nih.gov/39997250

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Background/Objectives: Cardiovascular diseases (CVD) are one of the major public health concerns worldwide due to their high morbidity and mortality rates. This situation has necessitated the development of tools to assess cardiovascular risk (CVR) in order to prevent the onset of CVD. The aim of this study is to assess how sociodemographic variables and health habits are associated with the values of CVR scales, such as REGICOR, SCORE2, and vascular age. Methodology: This is a descriptive and cross-sectional study involving 44,939 Spanish healthcare workers, where the association between age, sex, type of work, smoking, physical activity, and Mediterranean diet with CVR scales such as REGICOR, SCORE2, and vascular age was evaluated. Results: All the variables analyzed showed an association with the occurrence of moderate-high values in all three CVR scales. Age was the variable that showed the highest odds ratio values: 13.446 (95% CI 11.16-14.77) for REGICOR, 13.90 (95% CI 12.01-15.81) for vascular age, and 14.12 (95% CI 12.01-16.23) for SCORE2. Conclusions: The profile of a healthcare worker with the highest risk of presenting moderate-high values on all three CVR scales would be a male over 60 years old, a nursing assistant or orderly, a smoker, sedentary, and with low adherence to the Mediterranean diet.

  @article{marcos2025estimation,
  abstract = {Background/Objectives: Cardiovascular diseases (CVD) are one of the major public health concerns worldwide due to their high morbidity and mortality rates. This situation has necessitated the development of tools to assess cardiovascular risk (CVR) in order to prevent the onset of CVD. The aim of this study is to assess how sociodemographic variables and health habits are associated with the values of CVR scales, such as REGICOR, SCORE2, and vascular age. Methodology: This is a descriptive and cross-sectional study involving 44,939 Spanish healthcare workers, where the association between age, sex, type of work, smoking, physical activity, and Mediterranean diet with CVR scales such as REGICOR, SCORE2, and vascular age was evaluated. Results: All the variables analyzed showed an association with the occurrence of moderate-high values in all three CVR scales. Age was the variable that showed the highest odds ratio values: 13.446 (95% CI 11.16-14.77) for REGICOR, 13.90 (95% CI 12.01-15.81) for vascular age, and 14.12 (95% CI 12.01-16.23) for SCORE2. Conclusions: The profile of a healthcare worker with the highest risk of presenting moderate-high values on all three CVR scales would be a male over 60 years old, a nursing assistant or orderly, a smoker, sedentary, and with low adherence to the Mediterranean diet.},
  address = {Switzerland},
  author = {Marcos, Pedro Javier Tárraga and López, Pedro Juan Tárraga and López-González, Ángel Arturo and Rifá, Emilio Martínez-Almoyna and Oliveira, Hernán Paublini and Sánchez, Cristina Martorell and Ramírez-Manent, José Ignacio},
  journal = {Healthcare (Basel, Switzerland)},
  keywords = {grapp-caib},
  month = {feb},
  number = 4,
  pages = {375--},
  title = {Estimation of Cardiovascular Risk Using SCORE2, REGICOR and Vascular Age Scales in Spanish Healthcare Workers: A Retrospective Longitudinal Study},
  volume = 13,
  year = 2025
  }
  

  %0 Journal Article
  %1 marcos2025estimation
  %A Marcos, Pedro Javier Tárraga
  %A López, Pedro Juan Tárraga
  %A López-González, Ángel Arturo
  %A Rifá, Emilio Martínez-Almoyna
  %A Oliveira, Hernán Paublini
  %A Sánchez, Cristina Martorell
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Healthcare (Basel, Switzerland)
  %N 4
  %P 375--
  %R 10.3390/healthcare13040375
  %T Estimation of Cardiovascular Risk Using SCORE2, REGICOR and Vascular Age Scales in Spanish Healthcare Workers: A Retrospective Longitudinal Study
  %U https://pubmed.ncbi.nlm.nih.gov/39997250
  %V 13
  %X Background/Objectives: Cardiovascular diseases (CVD) are one of the major public health concerns worldwide due to their high morbidity and mortality rates. This situation has necessitated the development of tools to assess cardiovascular risk (CVR) in order to prevent the onset of CVD. The aim of this study is to assess how sociodemographic variables and health habits are associated with the values of CVR scales, such as REGICOR, SCORE2, and vascular age. Methodology: This is a descriptive and cross-sectional study involving 44,939 Spanish healthcare workers, where the association between age, sex, type of work, smoking, physical activity, and Mediterranean diet with CVR scales such as REGICOR, SCORE2, and vascular age was evaluated. Results: All the variables analyzed showed an association with the occurrence of moderate-high values in all three CVR scales. Age was the variable that showed the highest odds ratio values: 13.446 (95% CI 11.16-14.77) for REGICOR, 13.90 (95% CI 12.01-15.81) for vascular age, and 14.12 (95% CI 12.01-16.23) for SCORE2. Conclusions: The profile of a healthcare worker with the highest risk of presenting moderate-high values on all three CVR scales would be a male over 60 years old, a nursing assistant or orderly, a smoker, sedentary, and with low adherence to the Mediterranean diet.
  

• 
  1.

  Martínez-Almoyna Rifá E, López González Ángel A, Tárraga López PJ, Paublini H, Vallejos D, Ramírez Manent JI. Relationship between diabesity and elevated values of metabolic-associated steatotic liver disease risk scales in Spanish workers using body mass index and the body adiposity estimator criteria of Clínica de Navarra. Nutricion hospitalaria [Internet]. Spain; 2025 Mar.;:10.20960/nh.05441-. https://pubmed.ncbi.nlm.nih.gov/40195779

  AbstractURLBibTeXEndNoteDOIBibSonomy

  INTRODUCTION: diabesity (coexistence of diabetes and obesity) and metabolic associated steatotic liver disease (MASLD) are two very frequent pathologies whose prevalence is increasing every day. OBJECTIVE: to find out how these two pathological entities are associated in a group of Spanish workers. METHODOLOGY: a descriptive, cross-sectional study was carried out in 219477 workers to assess the association between diabesity (applying a double criterion, the body mass index BMI and the Clínica Universitaria de Navarra body adiposity estimator CUN BAE) and different risk scales for MASLD and liver fibrosis. RESULTS: all MASH and liver fibrosis risk scales show higher values in people with diabesity applying the two criteria compared to people without diabesity. CONCLUSION: diabesity and MASLD and liver fibrosis risk scales show a significant association in our study.

  @article{martinezalmoynarifa2025relationship,
  abstract = {INTRODUCTION: diabesity (coexistence of diabetes and obesity) and metabolic associated steatotic liver disease (MASLD) are two very frequent pathologies whose prevalence is increasing every day. OBJECTIVE: to find out how these two pathological entities are associated in a group of Spanish workers. METHODOLOGY: a descriptive, cross-sectional study was carried out in 219477 workers to assess the association between diabesity (applying a double criterion, the body mass index BMI and the Clínica Universitaria de Navarra body adiposity estimator CUN BAE) and different risk scales for MASLD and liver fibrosis. RESULTS: all MASH and liver fibrosis risk scales show higher values in people with diabesity applying the two criteria compared to people without diabesity. CONCLUSION: diabesity and MASLD and liver fibrosis risk scales show a significant association in our study.},
  address = {Spain},
  author = {Martínez-Almoyna Rifá, Emilio and López González, Ángel Arturo and Tárraga López, Pedro Juan and Paublini, Hernán and Vallejos, Daniela and Ramírez Manent, José Ignacio},
  journal = {Nutricion hospitalaria},
  keywords = {grapp-caib},
  month = {mar},
  pages = {10.20960/nh.05441--},
  title = {Relationship between diabesity and elevated values of metabolic-associated steatotic liver disease risk scales in Spanish workers using body mass index and the body adiposity estimator criteria of Clínica de Navarra},
  year = 2025
  }
  

  %0 Journal Article
  %1 martinezalmoynarifa2025relationship
  %A Martínez-Almoyna Rifá, Emilio
  %A López González, Ángel Arturo
  %A Tárraga López, Pedro Juan
  %A Paublini, Hernán
  %A Vallejos, Daniela
  %A Ramírez Manent, José Ignacio
  %C Spain
  %D 2025
  %J Nutricion hospitalaria
  %P 10.20960/nh.05441--
  %R 10.20960/nh.05441
  %T Relationship between diabesity and elevated values of metabolic-associated steatotic liver disease risk scales in Spanish workers using body mass index and the body adiposity estimator criteria of Clínica de Navarra
  %U https://pubmed.ncbi.nlm.nih.gov/40195779
  %X INTRODUCTION: diabesity (coexistence of diabetes and obesity) and metabolic associated steatotic liver disease (MASLD) are two very frequent pathologies whose prevalence is increasing every day. OBJECTIVE: to find out how these two pathological entities are associated in a group of Spanish workers. METHODOLOGY: a descriptive, cross-sectional study was carried out in 219477 workers to assess the association between diabesity (applying a double criterion, the body mass index BMI and the Clínica Universitaria de Navarra body adiposity estimator CUN BAE) and different risk scales for MASLD and liver fibrosis. RESULTS: all MASH and liver fibrosis risk scales show higher values in people with diabesity applying the two criteria compared to people without diabesity. CONCLUSION: diabesity and MASLD and liver fibrosis risk scales show a significant association in our study.
  

• 
  1.

  Pou Bordoy J, Leiva A, Albendín Ariza MJ, Llanos RE, Rigo Carratalà F, Romaguera D, Salas-Salvadó J, Babio N, Martinez-González MA, Toledo E, Fitó M, Aros F, Estruch R, Fiol Sala M. Major abnormalities of the electrocardiogram and cardiovascular risk in a medium and high-risk Mediterranean population. Medicina clinica [Internet]. Spain; 2025 Mar.;164(6):277-86. https://pubmed.ncbi.nlm.nih.gov/39706740

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: Major electrocardiogram abnormalities (MECG) are common in middle-aged and older individuals and could be an important factor in predicting cardiovascular events. OBJECTIVE: To analyse the association between MECG (Minnesota classification) and CVE independently of classic cardiovascular risk factors (CVRF), and to assess whether they improve the prediction according to the Spanish Coronary Event Risk Function (FRESCO). METHOD: 1.752 participants included in three nodes of the PREDIMED study aged between 55 and 80 years with medium or high CVRF. Mean follow-up time was 5.1 years. Cumulative CVE incidence was estimated by sex with and without MECG, and hazard ratios by sex were estimated using multivariate Cox regressions adjusted for randomization group and CCRF (FRESCO). Harrel's C Indices, Nam d'Agostino, Net Reclassification Improvement, and Integrated Discrimination Improvement were calculated. RESULTS: At baseline, 25% of the participants shows major electrocardiogram abnormalities (AMECG). During follow-up, there were 112 cardiovascular events (16 cardiovascular deaths, 15 acute myocardial infarctions, 38 anginas, 43 strokes). MECG were significantly associated with the onset of CVE. In men, left ventricular hypertrophy (LVH) criteria were associated with T-wave inversion (HR: 17.88, 95% CI: 5.51-58.03, pvalor<.001) and QT interval prolongation (HR: 2.41, 95% CI: 1.38-4.21, pvalor=.002); in women, atrial fibrillation (HR: 5.7, 95% CI: 1.76-18.72, pvalor=.006) and ST-segment depression (HR: 3.24, 95% CI: 1.36-7.71, pvalor<.001) were associated. No significant improvement in MECG prediction compared to FRESCO was observed. CONCLUSIONS: MECG are independently associated with the occurrence of CVE, but do not improve risk prediction beyond traditional risk factors.

  @article{poubordoy2025major,
  abstract = {INTRODUCTION: Major electrocardiogram abnormalities (MECG) are common in middle-aged and older individuals and could be an important factor in predicting cardiovascular events. OBJECTIVE: To analyse the association between MECG (Minnesota classification) and CVE independently of classic cardiovascular risk factors (CVRF), and to assess whether they improve the prediction according to the Spanish Coronary Event Risk Function (FRESCO). METHOD: 1.752 participants included in three nodes of the PREDIMED study aged between 55 and 80 years with medium or high CVRF. Mean follow-up time was 5.1 years. Cumulative CVE incidence was estimated by sex with and without MECG, and hazard ratios by sex were estimated using multivariate Cox regressions adjusted for randomization group and CCRF (FRESCO). Harrel's C Indices, Nam d'Agostino, Net Reclassification Improvement, and Integrated Discrimination Improvement were calculated. RESULTS: At baseline, 25% of the participants shows major electrocardiogram abnormalities (AMECG). During follow-up, there were 112 cardiovascular events (16 cardiovascular deaths, 15 acute myocardial infarctions, 38 anginas, 43 strokes). MECG were significantly associated with the onset of CVE. In men, left ventricular hypertrophy (LVH) criteria were associated with T-wave inversion (HR: 17.88, 95% CI: 5.51-58.03, pvalor<.001) and QT interval prolongation (HR: 2.41, 95% CI: 1.38-4.21, pvalor=.002); in women, atrial fibrillation (HR: 5.7, 95% CI: 1.76-18.72, pvalor=.006) and ST-segment depression (HR: 3.24, 95% CI: 1.36-7.71, pvalor<.001) were associated. No significant improvement in MECG prediction compared to FRESCO was observed. CONCLUSIONS: MECG are independently associated with the occurrence of CVE, but do not improve risk prediction beyond traditional risk factors.},
  address = {Spain},
  author = {Pou Bordoy, Joan and Leiva, Alfonso and Albendín Ariza, Maria José and Llanos, Roberto Elosúa and Rigo Carratalà, Fernando and Romaguera, Dora and Salas-Salvadó, Jordi and Babio, Nancy and Martinez-González, Miguel Angel and Toledo, Estefanía and Fitó, Montserrat and Aros, Fernando and Estruch, Ramon and Fiol Sala, Miquel},
  journal = {Medicina clinica},
  keywords = {grapp-caib},
  month = {mar},
  number = 6,
  pages = {277--286},
  title = {Major abnormalities of the electrocardiogram and cardiovascular risk in a medium and high-risk Mediterranean population},
  volume = 164,
  year = 2025
  }
  

  %0 Journal Article
  %1 poubordoy2025major
  %A Pou Bordoy, Joan
  %A Leiva, Alfonso
  %A Albendín Ariza, Maria José
  %A Llanos, Roberto Elosúa
  %A Rigo Carratalà, Fernando
  %A Romaguera, Dora
  %A Salas-Salvadó, Jordi
  %A Babio, Nancy
  %A Martinez-González, Miguel Angel
  %A Toledo, Estefanía
  %A Fitó, Montserrat
  %A Aros, Fernando
  %A Estruch, Ramon
  %A Fiol Sala, Miquel
  %C Spain
  %D 2025
  %J Medicina clinica
  %N 6
  %P 277--286
  %R 10.1016/j.medcli.2024.10.010
  %T Major abnormalities of the electrocardiogram and cardiovascular risk in a medium and high-risk Mediterranean population
  %U https://pubmed.ncbi.nlm.nih.gov/39706740
  %V 164
  %X INTRODUCTION: Major electrocardiogram abnormalities (MECG) are common in middle-aged and older individuals and could be an important factor in predicting cardiovascular events. OBJECTIVE: To analyse the association between MECG (Minnesota classification) and CVE independently of classic cardiovascular risk factors (CVRF), and to assess whether they improve the prediction according to the Spanish Coronary Event Risk Function (FRESCO). METHOD: 1.752 participants included in three nodes of the PREDIMED study aged between 55 and 80 years with medium or high CVRF. Mean follow-up time was 5.1 years. Cumulative CVE incidence was estimated by sex with and without MECG, and hazard ratios by sex were estimated using multivariate Cox regressions adjusted for randomization group and CCRF (FRESCO). Harrel's C Indices, Nam d'Agostino, Net Reclassification Improvement, and Integrated Discrimination Improvement were calculated. RESULTS: At baseline, 25% of the participants shows major electrocardiogram abnormalities (AMECG). During follow-up, there were 112 cardiovascular events (16 cardiovascular deaths, 15 acute myocardial infarctions, 38 anginas, 43 strokes). MECG were significantly associated with the onset of CVE. In men, left ventricular hypertrophy (LVH) criteria were associated with T-wave inversion (HR: 17.88, 95% CI: 5.51-58.03, pvalor<.001) and QT interval prolongation (HR: 2.41, 95% CI: 1.38-4.21, pvalor=.002); in women, atrial fibrillation (HR: 5.7, 95% CI: 1.76-18.72, pvalor=.006) and ST-segment depression (HR: 3.24, 95% CI: 1.36-7.71, pvalor<.001) were associated. No significant improvement in MECG prediction compared to FRESCO was observed. CONCLUSIONS: MECG are independently associated with the occurrence of CVE, but do not improve risk prediction beyond traditional risk factors.
  

• 
  1.

  Gómez-Gómez I, Rodero-Cosano ML, Bellón J Á, Zabaleta-Del-Olmo E, Maderuelo-Fernandez JA, Moreno-Peral P, Magallón-Botaya R, Oliván-Blázquez B, Casajuana-Closas M, López-Jiménez T, Bolíbar B, Llobera J, Clavería A, Sanchez-Perez A, Motrico E. Examining the influence of mental health and structural determinants of health on the stage of motivational readiness for health behaviour changes: A path analysis study. Journal of health psychology [Internet]. England; 2025 Mar.;30(3):470-85. https://pubmed.ncbi.nlm.nih.gov/38605575

  AbstractURLBibTeXEndNoteDOIBibSonomy

  This study explores the influence of mental health and structural determinants of health on motivational readiness for health behaviour change in 1462 Spanish primary healthcare users. Chi-square test and structural equation modelling were performed. Results showed that depression and anxiety were negatively associated with being in the action stages of motivational readiness for a healthy diet and physical activity. This association was statistically significant only for motivational readiness for a healthy diet and depression (β =  - 0.076; p = 0.046). Furthermore, women and workers were more likely to be in the action stages of motivational readiness for a healthy diet while older adults and adults with higher health-related quality of life were more likely to be in the action stages of motivational readiness for physical activity. The present study suggests that structural (being older, being a woman and being employed) and intermediary (suffering from depression and higher health-related quality of life) determinants of health influence motivational readiness for health behaviour changes.

  @article{gomezgomez2025examining,
  abstract = {This study explores the influence of mental health and structural determinants of health on motivational readiness for health behaviour change in 1462 Spanish primary healthcare users. Chi-square test and structural equation modelling were performed. Results showed that depression and anxiety were negatively associated with being in the action stages of motivational readiness for a healthy diet and physical activity. This association was statistically significant only for motivational readiness for a healthy diet and depression (β =  - 0.076; p = 0.046). Furthermore, women and workers were more likely to be in the action stages of motivational readiness for a healthy diet while older adults and adults with higher health-related quality of life were more likely to be in the action stages of motivational readiness for physical activity. The present study suggests that structural (being older, being a woman and being employed) and intermediary (suffering from depression and higher health-related quality of life) determinants of health influence motivational readiness for health behaviour changes.},
  address = {England},
  author = {Gómez-Gómez, Irene and Rodero-Cosano, María Luisa and Bellón, Juan Á and Zabaleta-Del-Olmo, Edurne and Maderuelo-Fernandez, José A and Moreno-Peral, Patricia and Magallón-Botaya, Rosa and Oliván-Blázquez, Bárbara and Casajuana-Closas, Marc and López-Jiménez, Tomàs and Bolíbar, Bonaventura and Llobera, Joan and Clavería, Ana and Sanchez-Perez, Alvaro and Motrico, Emma},
  journal = {Journal of health psychology},
  keywords = {grapp-caib},
  month = {mar},
  number = 3,
  pages = {470--485},
  title = {Examining the influence of mental health and structural determinants of health on the stage of motivational readiness for health behaviour changes: A path analysis study},
  volume = 30,
  year = 2025
  }
  

  %0 Journal Article
  %1 gomezgomez2025examining
  %A Gómez-Gómez, Irene
  %A Rodero-Cosano, María Luisa
  %A Bellón, Juan Á
  %A Zabaleta-Del-Olmo, Edurne
  %A Maderuelo-Fernandez, José A
  %A Moreno-Peral, Patricia
  %A Magallón-Botaya, Rosa
  %A Oliván-Blázquez, Bárbara
  %A Casajuana-Closas, Marc
  %A López-Jiménez, Tomàs
  %A Bolíbar, Bonaventura
  %A Llobera, Joan
  %A Clavería, Ana
  %A Sanchez-Perez, Alvaro
  %A Motrico, Emma
  %C England
  %D 2025
  %J Journal of health psychology
  %N 3
  %P 470--485
  %R 10.1177/13591053241241015
  %T Examining the influence of mental health and structural determinants of health on the stage of motivational readiness for health behaviour changes: A path analysis study
  %U https://pubmed.ncbi.nlm.nih.gov/38605575
  %V 30
  %X This study explores the influence of mental health and structural determinants of health on motivational readiness for health behaviour change in 1462 Spanish primary healthcare users. Chi-square test and structural equation modelling were performed. Results showed that depression and anxiety were negatively associated with being in the action stages of motivational readiness for a healthy diet and physical activity. This association was statistically significant only for motivational readiness for a healthy diet and depression (β =  - 0.076; p = 0.046). Furthermore, women and workers were more likely to be in the action stages of motivational readiness for a healthy diet while older adults and adults with higher health-related quality of life were more likely to be in the action stages of motivational readiness for physical activity. The present study suggests that structural (being older, being a woman and being employed) and intermediary (suffering from depression and higher health-related quality of life) determinants of health influence motivational readiness for health behaviour changes.
  

• 
  1.

  López González Ángel A, Martínez-Almoyna Rifá E, Paublini H, Martorrel Sánchez C, Tárraga López PJ, Ramírez-Manent JI. Association between sociodemographic variables, healthy habits and stress with vascular age and SCORE2. Nutricion hospitalaria [Internet]. Spain; 2025 Mar.;:10.20960/nh.05629-. https://pubmed.ncbi.nlm.nih.gov/40066594

  AbstractURLBibTeXEndNoteDOIBibSonomy

  INTRODUCTION: Cardiovascular diseases are a global public health concern due to their high morbidity, mortality, and prevalence. Numerous scales based on different risk factors have been used to assess cardiovascular risk (CVR). The aim of this study is to evaluate how various sociodemographic variables, healthy habits, and stress are associated with the values of two CVR scales. MATERIALS AND METHODS: a descriptive cross-sectional study was conducted with 22,976 Spanish workers, analyzing the association between sociodemographic variables (age, gender, socioeconomic status), healthy habits (smoking, alcohol consumption, adherence to the Mediterranean diet, and physical activity), and stress with two CVR scales: vascular age (VA) and the Systematic Coronary Risk Evaluation-2 (SCORE2). RESULTS: all the scales analyzed show an association with elevated VA and SCORE2 values. The variables with the strongest associations (highest odds ratios) are age, type of occupation, and smoking. CONCLUSIONS: the profile of individuals most at risk of having high VA and SCORE2 values is a male over 50 years old, belonging to lower socioeconomic strata (manual laborer), a smoker, a regular alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and high stress levels.

  @article{lopezgonzalez2025association,
  abstract = {INTRODUCTION: Cardiovascular diseases are a global public health concern due to their high morbidity, mortality, and prevalence. Numerous scales based on different risk factors have been used to assess cardiovascular risk (CVR). The aim of this study is to evaluate how various sociodemographic variables, healthy habits, and stress are associated with the values of two CVR scales. MATERIALS AND METHODS: a descriptive cross-sectional study was conducted with 22,976 Spanish workers, analyzing the association between sociodemographic variables (age, gender, socioeconomic status), healthy habits (smoking, alcohol consumption, adherence to the Mediterranean diet, and physical activity), and stress with two CVR scales: vascular age (VA) and the Systematic Coronary Risk Evaluation-2 (SCORE2). RESULTS: all the scales analyzed show an association with elevated VA and SCORE2 values. The variables with the strongest associations (highest odds ratios) are age, type of occupation, and smoking. CONCLUSIONS: the profile of individuals most at risk of having high VA and SCORE2 values is a male over 50 years old, belonging to lower socioeconomic strata (manual laborer), a smoker, a regular alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and high stress levels.},
  address = {Spain},
  author = {López González, Ángel Arturo and Martínez-Almoyna Rifá, Emilio and Paublini, Hernán and Martorrel Sánchez, Cristina and Tárraga López, Pedro Juan and Ramírez-Manent, José Ignacio},
  journal = {Nutricion hospitalaria},
  keywords = {grapp-caib},
  month = {mar},
  pages = {10.20960/nh.05629--},
  title = {Association between sociodemographic variables, healthy habits and stress with vascular age and SCORE2},
  year = 2025
  }
  

  %0 Journal Article
  %1 lopezgonzalez2025association
  %A López González, Ángel Arturo
  %A Martínez-Almoyna Rifá, Emilio
  %A Paublini, Hernán
  %A Martorrel Sánchez, Cristina
  %A Tárraga López, Pedro Juan
  %A Ramírez-Manent, José Ignacio
  %C Spain
  %D 2025
  %J Nutricion hospitalaria
  %P 10.20960/nh.05629--
  %R 10.20960/nh.05629
  %T Association between sociodemographic variables, healthy habits and stress with vascular age and SCORE2
  %U https://pubmed.ncbi.nlm.nih.gov/40066594
  %X INTRODUCTION: Cardiovascular diseases are a global public health concern due to their high morbidity, mortality, and prevalence. Numerous scales based on different risk factors have been used to assess cardiovascular risk (CVR). The aim of this study is to evaluate how various sociodemographic variables, healthy habits, and stress are associated with the values of two CVR scales. MATERIALS AND METHODS: a descriptive cross-sectional study was conducted with 22,976 Spanish workers, analyzing the association between sociodemographic variables (age, gender, socioeconomic status), healthy habits (smoking, alcohol consumption, adherence to the Mediterranean diet, and physical activity), and stress with two CVR scales: vascular age (VA) and the Systematic Coronary Risk Evaluation-2 (SCORE2). RESULTS: all the scales analyzed show an association with elevated VA and SCORE2 values. The variables with the strongest associations (highest odds ratios) are age, type of occupation, and smoking. CONCLUSIONS: the profile of individuals most at risk of having high VA and SCORE2 values is a male over 50 years old, belonging to lower socioeconomic strata (manual laborer), a smoker, a regular alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and high stress levels.
  

• 
  1.

  Montero Muñoz N, Tárraga López PJ, López-González Ángel A, Paublini H, Martorell Sánchez C, Marínez-Almoyna Rifá E, Ramírez-Manent JI. Association Between Mediterranean Diet and Other Healthy Habits and Sociodemographic Variables with the Values of Vascular and Heart Age in Spanish Workers. Nutrients [Internet]. Switzerland; 2025 Mar.;17(5):903-. https://pubmed.ncbi.nlm.nih.gov/40077773

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Introduction: The assessment of cardiovascular risk has traditionally relied on validated scales designed to estimate the likelihood of experiencing a cardiovascular event within a specific timeframe. In recent years, novel methodologies have emerged, offering a more objective evaluation of this risk through indicators such as vascular age (VA) and heart age (HA). Objective: This study aimed to investigate the relationship between sociodemographic factors, lifestyle behaviors, and their impact on VA and HA. Materials and Methods: A dual study design, encompassing both cross-sectional and longitudinal retrospective approaches, was conducted among a cohort of employees. The variables assessed included sociodemographic characteristics (age, sex, and socioeconomic status) and health-related habits (smoking, physical activity, adherence to the Mediterranean diet, and alcohol consumption). Results: The findings revealed that all analyzed variables were significantly associated with elevated VA and HA values. Among these, age demonstrated the strongest association, with odds ratios (OR) of 114.91 (95% CI: 100.45-131.43) for high HA and 34.48 (95% CI: 31.41-37.56) for high VA. Conclusions: The profile of individuals most at risk for elevated VA and HA encompasses males of advanced age, characterized by low socioeconomic status, a sedentary lifestyle, poor adherence to the Mediterranean diet, and regular alcohol consumption.

  @article{monteromunoz2025association,
  abstract = {Introduction: The assessment of cardiovascular risk has traditionally relied on validated scales designed to estimate the likelihood of experiencing a cardiovascular event within a specific timeframe. In recent years, novel methodologies have emerged, offering a more objective evaluation of this risk through indicators such as vascular age (VA) and heart age (HA). Objective: This study aimed to investigate the relationship between sociodemographic factors, lifestyle behaviors, and their impact on VA and HA. Materials and Methods: A dual study design, encompassing both cross-sectional and longitudinal retrospective approaches, was conducted among a cohort of employees. The variables assessed included sociodemographic characteristics (age, sex, and socioeconomic status) and health-related habits (smoking, physical activity, adherence to the Mediterranean diet, and alcohol consumption). Results: The findings revealed that all analyzed variables were significantly associated with elevated VA and HA values. Among these, age demonstrated the strongest association, with odds ratios (OR) of 114.91 (95% CI: 100.45-131.43) for high HA and 34.48 (95% CI: 31.41-37.56) for high VA. Conclusions: The profile of individuals most at risk for elevated VA and HA encompasses males of advanced age, characterized by low socioeconomic status, a sedentary lifestyle, poor adherence to the Mediterranean diet, and regular alcohol consumption.},
  address = {Switzerland},
  author = {Montero Muñoz, Natalia and Tárraga López, Pedro Juan and López-González, Ángel Arturo and Paublini, Hernán and Martorell Sánchez, Cristina and Marínez-Almoyna Rifá, Emilio and Ramírez-Manent, José Ignacio},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {mar},
  number = 5,
  pages = {903--},
  title = {Association Between Mediterranean Diet and Other Healthy Habits and Sociodemographic Variables with the Values of Vascular and Heart Age in Spanish Workers},
  volume = 17,
  year = 2025
  }
  

  %0 Journal Article
  %1 monteromunoz2025association
  %A Montero Muñoz, Natalia
  %A Tárraga López, Pedro Juan
  %A López-González, Ángel Arturo
  %A Paublini, Hernán
  %A Martorell Sánchez, Cristina
  %A Marínez-Almoyna Rifá, Emilio
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Nutrients
  %N 5
  %P 903--
  %R 10.3390/nu17050903
  %T Association Between Mediterranean Diet and Other Healthy Habits and Sociodemographic Variables with the Values of Vascular and Heart Age in Spanish Workers
  %U https://pubmed.ncbi.nlm.nih.gov/40077773
  %V 17
  %X Introduction: The assessment of cardiovascular risk has traditionally relied on validated scales designed to estimate the likelihood of experiencing a cardiovascular event within a specific timeframe. In recent years, novel methodologies have emerged, offering a more objective evaluation of this risk through indicators such as vascular age (VA) and heart age (HA). Objective: This study aimed to investigate the relationship between sociodemographic factors, lifestyle behaviors, and their impact on VA and HA. Materials and Methods: A dual study design, encompassing both cross-sectional and longitudinal retrospective approaches, was conducted among a cohort of employees. The variables assessed included sociodemographic characteristics (age, sex, and socioeconomic status) and health-related habits (smoking, physical activity, adherence to the Mediterranean diet, and alcohol consumption). Results: The findings revealed that all analyzed variables were significantly associated with elevated VA and HA values. Among these, age demonstrated the strongest association, with odds ratios (OR) of 114.91 (95% CI: 100.45-131.43) for high HA and 34.48 (95% CI: 31.41-37.56) for high VA. Conclusions: The profile of individuals most at risk for elevated VA and HA encompasses males of advanced age, characterized by low socioeconomic status, a sedentary lifestyle, poor adherence to the Mediterranean diet, and regular alcohol consumption.
  

• 
  1.

  García-Buades ME, Montañez-Juan M, Blahopoulou J, Ortiz-Bonnin S, Chela-Alvarez X, Bulilete O, Llobera J. Psychosocial Work Factors, Job Stress, and Self-Rated Health Among Hotel Housekeepers. Workplace health & safety [Internet]. United States; 2025 Mar.;73(3):116-30. https://pubmed.ncbi.nlm.nih.gov/39475436

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Hotel housekeeping is widely recognized as a poor-quality job due to its high demands and limited resources. Hotel housekeepers (HHs) face both hard physical work and mentally demanding conditions, yet psychosocial factors in this feminized and precarious occupation remain under-researched. To address this gap, this study examines HHs' exposure to psychosocial factors at work and their impact on job stress and self-rated health. METHODS: A cross-sectional survey of a random sample of 926 HHs in the Balearic Islands (Spain) assessed job stress, self-rated health, psychosocial factors (job demands and resources), and sociodemographic variables using the Copenhagen Psychosocial Questionnaire II (COPSOQ-II) and the National Health Survey. Descriptive analysis and hierarchical linear regression models were applied. RESULTS: The prevalence of job stress was 61.1% (95% confidence interval [CI] = [57.8%, 64.1%]), while the prevalence of poor self-rated health was 59.9% (95% CI = [56.6%, 62.9%]). Hotel housekeepers were highly exposed to job demands such as intense work pace, job-specific stressors, work-life conflict, and emotional demands; highly available job resources were role clarity, task meaning, and social support. Regression models revealed work pace, work-life conflict, nationality, and weak leader support as key predictors of job stress; and work-life conflict and leadership quality as key predictors of self-rated health. CONCLUSION/APPLICATION TO PRACTICE: Although considered an eminently physical job, psychosocial work factors play a key role in explaining HHs' job stress and self-rated health. Occupational health professionals should design workplace interventions to reduce work pace, mitigate work-life conflict, and enhance resources such as leader support, sense of community, and leadership quality.

  @article{garciabuades2025psychosocial,
  abstract = {BACKGROUND: Hotel housekeeping is widely recognized as a poor-quality job due to its high demands and limited resources. Hotel housekeepers (HHs) face both hard physical work and mentally demanding conditions, yet psychosocial factors in this feminized and precarious occupation remain under-researched. To address this gap, this study examines HHs' exposure to psychosocial factors at work and their impact on job stress and self-rated health. METHODS: A cross-sectional survey of a random sample of 926 HHs in the Balearic Islands (Spain) assessed job stress, self-rated health, psychosocial factors (job demands and resources), and sociodemographic variables using the Copenhagen Psychosocial Questionnaire II (COPSOQ-II) and the National Health Survey. Descriptive analysis and hierarchical linear regression models were applied. RESULTS: The prevalence of job stress was 61.1% (95% confidence interval [CI] = [57.8%, 64.1%]), while the prevalence of poor self-rated health was 59.9% (95% CI = [56.6%, 62.9%]). Hotel housekeepers were highly exposed to job demands such as intense work pace, job-specific stressors, work-life conflict, and emotional demands; highly available job resources were role clarity, task meaning, and social support. Regression models revealed work pace, work-life conflict, nationality, and weak leader support as key predictors of job stress; and work-life conflict and leadership quality as key predictors of self-rated health. CONCLUSION/APPLICATION TO PRACTICE: Although considered an eminently physical job, psychosocial work factors play a key role in explaining HHs' job stress and self-rated health. Occupational health professionals should design workplace interventions to reduce work pace, mitigate work-life conflict, and enhance resources such as leader support, sense of community, and leadership quality.},
  address = {United States},
  author = {García-Buades, M Esther and Montañez-Juan, Maribel and Blahopoulou, Joanna and Ortiz-Bonnin, Silvia and Chela-Alvarez, Xènia and Bulilete, Oana and Llobera, Joan},
  journal = {Workplace health & safety},
  keywords = {grapp-caib},
  month = {mar},
  number = 3,
  pages = {116--130},
  title = {Psychosocial Work Factors, Job Stress, and Self-Rated Health Among Hotel Housekeepers},
  volume = 73,
  year = 2025
  }
  

  %0 Journal Article
  %1 garciabuades2025psychosocial
  %A García-Buades, M Esther
  %A Montañez-Juan, Maribel
  %A Blahopoulou, Joanna
  %A Ortiz-Bonnin, Silvia
  %A Chela-Alvarez, Xènia
  %A Bulilete, Oana
  %A Llobera, Joan
  %C United States
  %D 2025
  %J Workplace health & safety
  %N 3
  %P 116--130
  %R 10.1177/21650799241282787
  %T Psychosocial Work Factors, Job Stress, and Self-Rated Health Among Hotel Housekeepers
  %U https://pubmed.ncbi.nlm.nih.gov/39475436
  %V 73
  %X BACKGROUND: Hotel housekeeping is widely recognized as a poor-quality job due to its high demands and limited resources. Hotel housekeepers (HHs) face both hard physical work and mentally demanding conditions, yet psychosocial factors in this feminized and precarious occupation remain under-researched. To address this gap, this study examines HHs' exposure to psychosocial factors at work and their impact on job stress and self-rated health. METHODS: A cross-sectional survey of a random sample of 926 HHs in the Balearic Islands (Spain) assessed job stress, self-rated health, psychosocial factors (job demands and resources), and sociodemographic variables using the Copenhagen Psychosocial Questionnaire II (COPSOQ-II) and the National Health Survey. Descriptive analysis and hierarchical linear regression models were applied. RESULTS: The prevalence of job stress was 61.1% (95% confidence interval [CI] = [57.8%, 64.1%]), while the prevalence of poor self-rated health was 59.9% (95% CI = [56.6%, 62.9%]). Hotel housekeepers were highly exposed to job demands such as intense work pace, job-specific stressors, work-life conflict, and emotional demands; highly available job resources were role clarity, task meaning, and social support. Regression models revealed work pace, work-life conflict, nationality, and weak leader support as key predictors of job stress; and work-life conflict and leadership quality as key predictors of self-rated health. CONCLUSION/APPLICATION TO PRACTICE: Although considered an eminently physical job, psychosocial work factors play a key role in explaining HHs' job stress and self-rated health. Occupational health professionals should design workplace interventions to reduce work pace, mitigate work-life conflict, and enhance resources such as leader support, sense of community, and leadership quality.
  

• 
  1.

  Tárraga Marcos PJ, López-González Ángel A, Martínez-Almoyna Rifá E, Paublini Oliveira H, Martorell Sánchez C, Tárraga López PJ, Ramírez-Manent JI. Risk of Insulin Resistance in 44,939 Spanish Healthcare Workers: Association with Sociodemographic Variables and Healthy Habits. Diseases (Basel, Switzerland) [Internet]. Switzerland; 2025 Jan.;13(2):33-. https://pubmed.ncbi.nlm.nih.gov/39997040

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Introduction: Insulin resistance (IR) is a highly prevalent pathophysiological entity implicated in the development of a wide variety of metabolic, cardiovascular, and endocrine disorders. The aim of this study is to assess the association between sociodemographic variables and healthy habits with IR risk scales. Methodology: This dual study, incorporating both longitudinal-retrospective and cross-sectional designs, analyzed healthcare workers across four professional categories (physicians, nurses, healthcare technicians, and auxiliary personnel). It examined the association of age, sex, professional category, smoking status, physical activity, and adherence to the Mediterranean diet with elevated scores on insulin resistance risk scales. Results: All the variables analyzed were associated with the presence of elevated values of the IR scales, with age, sex, and physical activity showing the strongest association (reflected in the odds ratio values). Conclusions: The profile of an individual with a higher risk of presenting elevated values of the IR risk scales would be an elderly male auxiliary health worker who is a smoker and is physically inactive, with a low adherence to the Mediterranean diet.

  @article{tarragamarcos2025insulin,
  abstract = {Introduction: Insulin resistance (IR) is a highly prevalent pathophysiological entity implicated in the development of a wide variety of metabolic, cardiovascular, and endocrine disorders. The aim of this study is to assess the association between sociodemographic variables and healthy habits with IR risk scales. Methodology: This dual study, incorporating both longitudinal-retrospective and cross-sectional designs, analyzed healthcare workers across four professional categories (physicians, nurses, healthcare technicians, and auxiliary personnel). It examined the association of age, sex, professional category, smoking status, physical activity, and adherence to the Mediterranean diet with elevated scores on insulin resistance risk scales. Results: All the variables analyzed were associated with the presence of elevated values of the IR scales, with age, sex, and physical activity showing the strongest association (reflected in the odds ratio values). Conclusions: The profile of an individual with a higher risk of presenting elevated values of the IR risk scales would be an elderly male auxiliary health worker who is a smoker and is physically inactive, with a low adherence to the Mediterranean diet.},
  address = {Switzerland},
  author = {Tárraga Marcos, Pedro Javier and López-González, Ángel Arturo and Martínez-Almoyna Rifá, Emilio and Paublini Oliveira, Hernán and Martorell Sánchez, Cristina and Tárraga López, Pedro Juan and Ramírez-Manent, José Ignacio},
  journal = {Diseases (Basel, Switzerland)},
  keywords = {grapp-caib},
  month = {jan},
  number = 2,
  pages = {33--},
  title = {Risk of Insulin Resistance in 44,939 Spanish Healthcare Workers: Association with Sociodemographic Variables and Healthy Habits},
  volume = 13,
  year = 2025
  }
  

  %0 Journal Article
  %1 tarragamarcos2025insulin
  %A Tárraga Marcos, Pedro Javier
  %A López-González, Ángel Arturo
  %A Martínez-Almoyna Rifá, Emilio
  %A Paublini Oliveira, Hernán
  %A Martorell Sánchez, Cristina
  %A Tárraga López, Pedro Juan
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Diseases (Basel, Switzerland)
  %N 2
  %P 33--
  %R 10.3390/diseases13020033
  %T Risk of Insulin Resistance in 44,939 Spanish Healthcare Workers: Association with Sociodemographic Variables and Healthy Habits
  %U https://pubmed.ncbi.nlm.nih.gov/39997040
  %V 13
  %X Introduction: Insulin resistance (IR) is a highly prevalent pathophysiological entity implicated in the development of a wide variety of metabolic, cardiovascular, and endocrine disorders. The aim of this study is to assess the association between sociodemographic variables and healthy habits with IR risk scales. Methodology: This dual study, incorporating both longitudinal-retrospective and cross-sectional designs, analyzed healthcare workers across four professional categories (physicians, nurses, healthcare technicians, and auxiliary personnel). It examined the association of age, sex, professional category, smoking status, physical activity, and adherence to the Mediterranean diet with elevated scores on insulin resistance risk scales. Results: All the variables analyzed were associated with the presence of elevated values of the IR scales, with age, sex, and physical activity showing the strongest association (reflected in the odds ratio values). Conclusions: The profile of an individual with a higher risk of presenting elevated values of the IR risk scales would be an elderly male auxiliary health worker who is a smoker and is physically inactive, with a low adherence to the Mediterranean diet.
  

• 
  1.

  Mira-Martínez S, Zamanillo-Campos R, Malih N, Fiol deRoque MA, Angullo-Martínez E, Jimenez R, Serrano-Ripoll MJ, Leiva A, Oña JI, Galmes-Panades AM, Bennasar-Veny M, Yañez AM, Gómez-Juanes R, Konieczna J, Miralles J, Romaguera D, Vidal-Thomasa MC, Llobera-Canaves J, García-Toro M, Gervilla-García E, Vicens C, Bulilete O, Montaño JJ, Gili M, Roca M, Colom A, Ricci-Cabello I. Describing the initial results of a pragmatic, cluster randomized clinical trial to examine the impact of a multifaceted digital intervention for the prevention of type 2 diabetes mellitus in the primary care setting: intervention design, recruitment strategy and participants’ baseline characteristics of the PREDIABETEXT trial. Frontiers in endocrinology [Internet]. Switzerland; 2025 Mar.;16:1524336-. https://pubmed.ncbi.nlm.nih.gov/40230484

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: i) to describe PREDIABETEXT, a novel digital intervention for the prevention of type 2 diabetes; ii) to examine the performance of a strategy for virtual recruitment of participants in a trial to assess its impact, and; iii) to determine the baseline characteristics of the enrolled participants. METHODS: We developed PREDIABETEXT in a multistage process involving systematic literature reviews and qualitative research with end users (primary care patients and professionals). We combined multiple virtual strategies (SMS, phone calls, promotional videos) to recruit healthcare professionals and their patients. We collected baseline data from patients (sociodemographic, behavioral and clinical) and healthcare professionals (sociodemographic and professional experience). RESULTS: The intervention consisted in delivering personalized short text messages supporting lifestyle behavior changes to people at risk of type 2 diabetes; and online training to their primary healthcare professionals. We recruited 58/133 (43.6%) professionals (30 doctors; 28 nurses) from 16 centers. Most professionals (83%) were women [mean (SD) age 49.69 (10.15)]. We recruited 365/976 (37.4%) patients (54.5% women, 59.82 (9.77) years old. Around half (55.3%) presented obesity (BMI ≥25), 65% hypertension, 43.3% hypercholesterolemia, and 14.8% hypertriglyceridemia. CONCLUSIONS: The PREDIABETEX trial successfully recruited a representative sample of patients at risk of type 2 diabetes and their healthcare providers.

  @article{miramartinez2025describing,
  abstract = {INTRODUCTION: i) to describe PREDIABETEXT, a novel digital intervention for the prevention of type 2 diabetes; ii) to examine the performance of a strategy for virtual recruitment of participants in a trial to assess its impact, and; iii) to determine the baseline characteristics of the enrolled participants. METHODS: We developed PREDIABETEXT in a multistage process involving systematic literature reviews and qualitative research with end users (primary care patients and professionals). We combined multiple virtual strategies (SMS, phone calls, promotional videos) to recruit healthcare professionals and their patients. We collected baseline data from patients (sociodemographic, behavioral and clinical) and healthcare professionals (sociodemographic and professional experience). RESULTS: The intervention consisted in delivering personalized short text messages supporting lifestyle behavior changes to people at risk of type 2 diabetes; and online training to their primary healthcare professionals. We recruited 58/133 (43.6%) professionals (30 doctors; 28 nurses) from 16 centers. Most professionals (83%) were women [mean (SD) age 49.69 (10.15)]. We recruited 365/976 (37.4%) patients (54.5% women, 59.82 (9.77) years old. Around half (55.3%) presented obesity (BMI ≥25), 65% hypertension, 43.3% hypercholesterolemia, and 14.8% hypertriglyceridemia. CONCLUSIONS: The PREDIABETEX trial successfully recruited a representative sample of patients at risk of type 2 diabetes and their healthcare providers.},
  address = {Switzerland},
  author = {Mira-Martínez, Sofía and Zamanillo-Campos, Rocío and Malih, Narges and Fiol deRoque, Maria Antonia and Angullo-Martínez, Escarlata and Jimenez, Rafael and Serrano-Ripoll, Maria Jesús and Leiva, Alfonso and Oña, José Iván and Galmes-Panades, Aina M and Bennasar-Veny, Miquel and Yañez, Aina Maria and Gómez-Juanes, Rocío and Konieczna, Jadwiga and Miralles, Jerónima and Romaguera, Dora and Vidal-Thomasa, María Clara and Llobera-Canaves, Joan and García-Toro, Mauro and Gervilla-García, Elena and Vicens, Catalina and Bulilete, Oana and Montaño, Juan José and Gili, Margalida and Roca, Miquel and Colom, Antoni and Ricci-Cabello, Ignacio},
  journal = {Frontiers in endocrinology},
  keywords = {evisap grapp-caib},
  month = {mar},
  pages = {1524336--1524336},
  title = {Describing the initial results of a pragmatic, cluster randomized clinical trial to examine the impact of a multifaceted digital intervention for the prevention of type 2 diabetes mellitus in the primary care setting: intervention design, recruitment strategy and participants' baseline characteristics of the PREDIABETEXT trial},
  volume = 16,
  year = 2025
  }
  

  %0 Journal Article
  %1 miramartinez2025describing
  %A Mira-Martínez, Sofía
  %A Zamanillo-Campos, Rocío
  %A Malih, Narges
  %A Fiol deRoque, Maria Antonia
  %A Angullo-Martínez, Escarlata
  %A Jimenez, Rafael
  %A Serrano-Ripoll, Maria Jesús
  %A Leiva, Alfonso
  %A Oña, José Iván
  %A Galmes-Panades, Aina M
  %A Bennasar-Veny, Miquel
  %A Yañez, Aina Maria
  %A Gómez-Juanes, Rocío
  %A Konieczna, Jadwiga
  %A Miralles, Jerónima
  %A Romaguera, Dora
  %A Vidal-Thomasa, María Clara
  %A Llobera-Canaves, Joan
  %A García-Toro, Mauro
  %A Gervilla-García, Elena
  %A Vicens, Catalina
  %A Bulilete, Oana
  %A Montaño, Juan José
  %A Gili, Margalida
  %A Roca, Miquel
  %A Colom, Antoni
  %A Ricci-Cabello, Ignacio
  %C Switzerland
  %D 2025
  %J Frontiers in endocrinology
  %P 1524336--1524336
  %R 10.3389/fendo.2025.1524336
  %T Describing the initial results of a pragmatic, cluster randomized clinical trial to examine the impact of a multifaceted digital intervention for the prevention of type 2 diabetes mellitus in the primary care setting: intervention design, recruitment strategy and participants' baseline characteristics of the PREDIABETEXT trial
  %U https://pubmed.ncbi.nlm.nih.gov/40230484
  %V 16
  %X INTRODUCTION: i) to describe PREDIABETEXT, a novel digital intervention for the prevention of type 2 diabetes; ii) to examine the performance of a strategy for virtual recruitment of participants in a trial to assess its impact, and; iii) to determine the baseline characteristics of the enrolled participants. METHODS: We developed PREDIABETEXT in a multistage process involving systematic literature reviews and qualitative research with end users (primary care patients and professionals). We combined multiple virtual strategies (SMS, phone calls, promotional videos) to recruit healthcare professionals and their patients. We collected baseline data from patients (sociodemographic, behavioral and clinical) and healthcare professionals (sociodemographic and professional experience). RESULTS: The intervention consisted in delivering personalized short text messages supporting lifestyle behavior changes to people at risk of type 2 diabetes; and online training to their primary healthcare professionals. We recruited 58/133 (43.6%) professionals (30 doctors; 28 nurses) from 16 centers. Most professionals (83%) were women [mean (SD) age 49.69 (10.15)]. We recruited 365/976 (37.4%) patients (54.5% women, 59.82 (9.77) years old. Around half (55.3%) presented obesity (BMI ≥25), 65% hypertension, 43.3% hypercholesterolemia, and 14.8% hypertriglyceridemia. CONCLUSIONS: The PREDIABETEX trial successfully recruited a representative sample of patients at risk of type 2 diabetes and their healthcare providers.
  

• 
  1.

  Serrano-Ripoll MJ, Zamanillo-Campos R, Mira Martínez S, Fiol deRoque MA, Malih N, Angullo-Martínez E, Ricci-Cabello I. Engaging Primary Care Professionals and People at Risk of Type 2 Diabetes in the Design of PREDIABETEXT, a Multifaceted Digital Intervention Aimed at Preventing Type 2 Diabetes: A Qualitative Study. Diabetology. 2025;6.

  AbstractBibTeXEndNoteBibSonomy

  Objectives: This study aims to explore perspectives and opinions from healthcare professionals and people at risk of type 2 diabetes mellitus (T2DM) to inform the design of PREDIABETEXT, a new digital multifaceted intervention to prevent T2DM. Methods: in this qualitative study, we purposefully recruited 15 healthcare professionals (doctors and nurses) working in primary healthcare centers in Mallorca (Spain), and 15 of their patients at risk of T2DM (HbA1c 6–6.4%, and/or fasting plasma glucose 110–125 mg/dL). We collected the data through semi-structured phone interviews, using an interview guide aimed at gathering participants’ views about the two PREDIABETEXT proposed co-interventions (educational intervention targeted at professionals and delivered as an online training course, and behavioral intervention targeted at individuals at risk of T2DM and delivered using SMS short text messages). The interviews were audio-recorded, verbatim transcribed, and analyzed using a thematic analysis approach. Results: Primary healthcare professionals valued a prediabetes training course for standardizing care and supporting diabetes prevention. They preferred a blended format with content on early detection, intervention, and monitoring. They perceived SMS reminders to their patients as potentially useful for reinforcing guidelines and improving care. Individuals at risk of T2DM, who faced challenges maintaining a healthy diet and exercise routine, viewed SMS as potentially motivational and informative, offering suggestions on content, format, and frequency to enhance its intended benefits. Conclusions: This qualitative study provided valuable insights from primary care professionals and people at risk of T2DM that will inform the user-centered design of the PREDIABETEXT intervention.

  @article{serranoripoll2025engaging,
  abstract = {Objectives: This study aims to explore perspectives and opinions from healthcare professionals and people at risk of type 2 diabetes mellitus (T2DM) to inform the design of PREDIABETEXT, a new digital multifaceted intervention to prevent T2DM. Methods: in this qualitative study, we purposefully recruited 15 healthcare professionals (doctors and nurses) working in primary healthcare centers in Mallorca (Spain), and 15 of their patients at risk of T2DM (HbA1c 6–6.4%, and/or fasting plasma glucose 110–125 mg/dL). We collected the data through semi-structured phone interviews, using an interview guide aimed at gathering participants’ views about the two PREDIABETEXT proposed co-interventions (educational intervention targeted at professionals and delivered as an online training course, and behavioral intervention targeted at individuals at risk of T2DM and delivered using SMS short text messages). The interviews were audio-recorded, verbatim transcribed, and analyzed using a thematic analysis approach. Results: Primary healthcare professionals valued a prediabetes training course for standardizing care and supporting diabetes prevention. They preferred a blended format with content on early detection, intervention, and monitoring. They perceived SMS reminders to their patients as potentially useful for reinforcing guidelines and improving care. Individuals at risk of T2DM, who faced challenges maintaining a healthy diet and exercise routine, viewed SMS as potentially motivational and informative, offering suggestions on content, format, and frequency to enhance its intended benefits. Conclusions: This qualitative study provided valuable insights from primary care professionals and people at risk of T2DM that will inform the user-centered design of the PREDIABETEXT intervention.},
  author = {Serrano-Ripoll, Maria J. and Zamanillo-Campos, Rocío and Mira Martínez, Sofía and Fiol deRoque, Maria A. and Malih, Narges and Angullo-Martínez, Escarlata and Ricci-Cabello, Ignacio},
  booktitle = {Diabetology},
  keywords = {evisap},
  series = 1,
  title = {Engaging Primary Care Professionals and People at Risk of Type 2 Diabetes in the Design of PREDIABETEXT, a Multifaceted Digital Intervention Aimed at Preventing Type 2 Diabetes: A Qualitative Study},
  volume = 6,
  year = 2025
  }
  

  %0 Journal Article
  %1 serranoripoll2025engaging
  %A Serrano-Ripoll, Maria J.
  %A Zamanillo-Campos, Rocío
  %A Mira Martínez, Sofía
  %A Fiol deRoque, Maria A.
  %A Malih, Narges
  %A Angullo-Martínez, Escarlata
  %A Ricci-Cabello, Ignacio
  %B Diabetology
  %D 2025
  %T Engaging Primary Care Professionals and People at Risk of Type 2 Diabetes in the Design of PREDIABETEXT, a Multifaceted Digital Intervention Aimed at Preventing Type 2 Diabetes: A Qualitative Study
  %V 6
  %X Objectives: This study aims to explore perspectives and opinions from healthcare professionals and people at risk of type 2 diabetes mellitus (T2DM) to inform the design of PREDIABETEXT, a new digital multifaceted intervention to prevent T2DM. Methods: in this qualitative study, we purposefully recruited 15 healthcare professionals (doctors and nurses) working in primary healthcare centers in Mallorca (Spain), and 15 of their patients at risk of T2DM (HbA1c 6–6.4%, and/or fasting plasma glucose 110–125 mg/dL). We collected the data through semi-structured phone interviews, using an interview guide aimed at gathering participants’ views about the two PREDIABETEXT proposed co-interventions (educational intervention targeted at professionals and delivered as an online training course, and behavioral intervention targeted at individuals at risk of T2DM and delivered using SMS short text messages). The interviews were audio-recorded, verbatim transcribed, and analyzed using a thematic analysis approach. Results: Primary healthcare professionals valued a prediabetes training course for standardizing care and supporting diabetes prevention. They preferred a blended format with content on early detection, intervention, and monitoring. They perceived SMS reminders to their patients as potentially useful for reinforcing guidelines and improving care. Individuals at risk of T2DM, who faced challenges maintaining a healthy diet and exercise routine, viewed SMS as potentially motivational and informative, offering suggestions on content, format, and frequency to enhance its intended benefits. Conclusions: This qualitative study provided valuable insights from primary care professionals and people at risk of T2DM that will inform the user-centered design of the PREDIABETEXT intervention.
  

• 
  1.

  Tárraga Marcos PJ, López-González Ángel A, Martínez-Almoyna Rifá E, Paublini Oliveira H, Martorell Sánchez C, Tárraga López PJ, Ramírez-Manent JI. Body Fat and Visceral Fat Values in Spanish Healthcare Workers: Associated Variables. Nutrients [Internet]. Switzerland; 2025 Feb.;17(4):649-. https://pubmed.ncbi.nlm.nih.gov/40004977

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND/OBJECTIVES: Excessive body adiposity is a significant public health challenge on a global scale. This study aimed to investigate the association between various sociodemographic factors and healthy lifestyle habits and the presence or absence of elevated body adiposity levels. METHODOLOGY: Two studies were conducted, a retrospective longitudinal study and a cross-sectional descriptive study. The analysis included 44,939 healthcare workers, categorised into four professional groups, to explore the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet and body adiposity, assessed as elevated body fat (BF) and visceral fat (VF) levels. Descriptive statistics encompassed categorical and quantitative variables, analysed using frequencies, Student's t-tests, chi-square tests, and multinomial logistic regression models. Associations, concordances, and correlations were further examined using logistic regression and Cohen's and Pearson's kappa coefficients. RESULTS: Age, sex, and physical activity were the factors most strongly associated with elevated BF and VF levels. Odds ratios (ORs) indicated the following significant associations: individuals aged 60 years and older exhibited ORs of 6.71 (95% CI: 5.68-7.74) for BF and 12.18 (95% CI: 10.01-14.26) for VF; male sex was associated with ORs of 2.21 (95% CI: 2.06-2.36) for BF and 12.51 (95% CI: 11.29-13.74) for VF. Sedentary behaviour was linked to ORs of 3.69 (95% CI: 3.41-3.97) for BF and 4.20 (95% CI: 3.78-4.63) for VF. Among healthcare professionals, nursing assistants and orderlies demonstrated the highest levels of adipose tissue accumulation. CONCLUSIONS: Elevated BF and VF levels among healthcare personnel are significantly associated by lifestyle factors, sex, and age, with the most pronounced risk observed in nursing assistants and orderlies. Further research focusing on the causal relationships between lifestyle behaviours and adiposity in this population will provide valuable insights and support the design of targeted preventive strategies to mitigate its prevalence.

  @article{tarragamarcos2025visceral,
  abstract = {BACKGROUND/OBJECTIVES: Excessive body adiposity is a significant public health challenge on a global scale. This study aimed to investigate the association between various sociodemographic factors and healthy lifestyle habits and the presence or absence of elevated body adiposity levels. METHODOLOGY: Two studies were conducted, a retrospective longitudinal study and a cross-sectional descriptive study. The analysis included 44,939 healthcare workers, categorised into four professional groups, to explore the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet and body adiposity, assessed as elevated body fat (BF) and visceral fat (VF) levels. Descriptive statistics encompassed categorical and quantitative variables, analysed using frequencies, Student's t-tests, chi-square tests, and multinomial logistic regression models. Associations, concordances, and correlations were further examined using logistic regression and Cohen's and Pearson's kappa coefficients. RESULTS: Age, sex, and physical activity were the factors most strongly associated with elevated BF and VF levels. Odds ratios (ORs) indicated the following significant associations: individuals aged 60 years and older exhibited ORs of 6.71 (95% CI: 5.68-7.74) for BF and 12.18 (95% CI: 10.01-14.26) for VF; male sex was associated with ORs of 2.21 (95% CI: 2.06-2.36) for BF and 12.51 (95% CI: 11.29-13.74) for VF. Sedentary behaviour was linked to ORs of 3.69 (95% CI: 3.41-3.97) for BF and 4.20 (95% CI: 3.78-4.63) for VF. Among healthcare professionals, nursing assistants and orderlies demonstrated the highest levels of adipose tissue accumulation. CONCLUSIONS: Elevated BF and VF levels among healthcare personnel are significantly associated by lifestyle factors, sex, and age, with the most pronounced risk observed in nursing assistants and orderlies. Further research focusing on the causal relationships between lifestyle behaviours and adiposity in this population will provide valuable insights and support the design of targeted preventive strategies to mitigate its prevalence.},
  address = {Switzerland},
  author = {Tárraga Marcos, Pedro Javier and López-González, Ángel Arturo and Martínez-Almoyna Rifá, Emilio and Paublini Oliveira, Hernán and Martorell Sánchez, Cristina and Tárraga López, Pedro Juan and Ramírez-Manent, José Ignacio},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {feb},
  number = 4,
  pages = {649--},
  title = {Body Fat and Visceral Fat Values in Spanish Healthcare Workers: Associated Variables},
  volume = 17,
  year = 2025
  }
  

  %0 Journal Article
  %1 tarragamarcos2025visceral
  %A Tárraga Marcos, Pedro Javier
  %A López-González, Ángel Arturo
  %A Martínez-Almoyna Rifá, Emilio
  %A Paublini Oliveira, Hernán
  %A Martorell Sánchez, Cristina
  %A Tárraga López, Pedro Juan
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Nutrients
  %N 4
  %P 649--
  %R 10.3390/nu17040649
  %T Body Fat and Visceral Fat Values in Spanish Healthcare Workers: Associated Variables
  %U https://pubmed.ncbi.nlm.nih.gov/40004977
  %V 17
  %X BACKGROUND/OBJECTIVES: Excessive body adiposity is a significant public health challenge on a global scale. This study aimed to investigate the association between various sociodemographic factors and healthy lifestyle habits and the presence or absence of elevated body adiposity levels. METHODOLOGY: Two studies were conducted, a retrospective longitudinal study and a cross-sectional descriptive study. The analysis included 44,939 healthcare workers, categorised into four professional groups, to explore the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet and body adiposity, assessed as elevated body fat (BF) and visceral fat (VF) levels. Descriptive statistics encompassed categorical and quantitative variables, analysed using frequencies, Student's t-tests, chi-square tests, and multinomial logistic regression models. Associations, concordances, and correlations were further examined using logistic regression and Cohen's and Pearson's kappa coefficients. RESULTS: Age, sex, and physical activity were the factors most strongly associated with elevated BF and VF levels. Odds ratios (ORs) indicated the following significant associations: individuals aged 60 years and older exhibited ORs of 6.71 (95% CI: 5.68-7.74) for BF and 12.18 (95% CI: 10.01-14.26) for VF; male sex was associated with ORs of 2.21 (95% CI: 2.06-2.36) for BF and 12.51 (95% CI: 11.29-13.74) for VF. Sedentary behaviour was linked to ORs of 3.69 (95% CI: 3.41-3.97) for BF and 4.20 (95% CI: 3.78-4.63) for VF. Among healthcare professionals, nursing assistants and orderlies demonstrated the highest levels of adipose tissue accumulation. CONCLUSIONS: Elevated BF and VF levels among healthcare personnel are significantly associated by lifestyle factors, sex, and age, with the most pronounced risk observed in nursing assistants and orderlies. Further research focusing on the causal relationships between lifestyle behaviours and adiposity in this population will provide valuable insights and support the design of targeted preventive strategies to mitigate its prevalence.
  

• 
  1.

  López-González Á A, Martínez-Almoyna Rifá E, Paublini Oliveira H, Martorell Sánchez C, Tárraga López PJ, Ramírez-Manent JI. Association between sociodemographic variables, healthy habits and stress with metabolic syndrome. A descriptive, cross-sectional study. Semergen [Internet]. Spain; 2025 Feb.;51(6):102455-. https://pubmed.ncbi.nlm.nih.gov/39922044

  AbstractURLBibTeXEndNoteDOIBibSonomy

  INTRODUCTION: Metabolic syndrome (MS) is a pathological condition that encompasses various cardiometabolic risk factors, such as obesity, dyslipidemia, hyperglycemia, and elevated blood pressure levels. It is considered a multifactorial pathological condition. The aim of this study is to assess how variables such as age, sex, socioeconomic status, tobacco and alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress are associated with the prevalence of MS, determined using two different criteria. MATERIALS AND METHODS: This is a descriptive, cross-sectional study conducted on 24,224 Spanish workers, evaluating the association between sociodemographic variables, health habits, and stress with MS, determined using two criteria: the National Cholesterol Education Program, Adult Treatment Panel III (NCEP ATP-III), and the International Diabetes Federation (IDF). RESULTS: All the variables analyzed showed an association with the presence of MS when applying both criteria. Among them, the variables with the strongest association were age: odds ratio 5.55 (95% CI: 4.80-6.30) for MS using the NCEP ATP-III criteria and 6.71 (95% CI: 5.30-8.13) for IDF criteria; and type of job: odds ratio 3.42 (95% CI: 2.95-3.90) for NCEP ATP-III and 3.57 (95% CI: 3.12-4.03) for IDF. CONCLUSIONS: The profile of an individual at higher risk of developing MS under both criteria would be an older male, manual laborer, smoker, habitual alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high levels of stress.

  @article{lopezgonzalez2025association,
  abstract = {INTRODUCTION: Metabolic syndrome (MS) is a pathological condition that encompasses various cardiometabolic risk factors, such as obesity, dyslipidemia, hyperglycemia, and elevated blood pressure levels. It is considered a multifactorial pathological condition. The aim of this study is to assess how variables such as age, sex, socioeconomic status, tobacco and alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress are associated with the prevalence of MS, determined using two different criteria. MATERIALS AND METHODS: This is a descriptive, cross-sectional study conducted on 24,224 Spanish workers, evaluating the association between sociodemographic variables, health habits, and stress with MS, determined using two criteria: the National Cholesterol Education Program, Adult Treatment Panel III (NCEP ATP-III), and the International Diabetes Federation (IDF). RESULTS: All the variables analyzed showed an association with the presence of MS when applying both criteria. Among them, the variables with the strongest association were age: odds ratio 5.55 (95% CI: 4.80-6.30) for MS using the NCEP ATP-III criteria and 6.71 (95% CI: 5.30-8.13) for IDF criteria; and type of job: odds ratio 3.42 (95% CI: 2.95-3.90) for NCEP ATP-III and 3.57 (95% CI: 3.12-4.03) for IDF. CONCLUSIONS: The profile of an individual at higher risk of developing MS under both criteria would be an older male, manual laborer, smoker, habitual alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high levels of stress.},
  address = {Spain},
  author = {López-González, Á A and Martínez-Almoyna Rifá, E and Paublini Oliveira, H and Martorell Sánchez, C and Tárraga López, P J and Ramírez-Manent, J I},
  journal = {Semergen},
  keywords = {grapp-caib},
  month = {feb},
  number = 6,
  pages = {102455--102455},
  title = {Association between sociodemographic variables, healthy habits and stress with metabolic syndrome. A descriptive, cross-sectional study},
  volume = 51,
  year = 2025
  }
  

  %0 Journal Article
  %1 lopezgonzalez2025association
  %A López-González, Á A
  %A Martínez-Almoyna Rifá, E
  %A Paublini Oliveira, H
  %A Martorell Sánchez, C
  %A Tárraga López, P J
  %A Ramírez-Manent, J I
  %C Spain
  %D 2025
  %J Semergen
  %N 6
  %P 102455--102455
  %R 10.1016/j.semerg.2025.102455
  %T Association between sociodemographic variables, healthy habits and stress with metabolic syndrome. A descriptive, cross-sectional study
  %U https://pubmed.ncbi.nlm.nih.gov/39922044
  %V 51
  %X INTRODUCTION: Metabolic syndrome (MS) is a pathological condition that encompasses various cardiometabolic risk factors, such as obesity, dyslipidemia, hyperglycemia, and elevated blood pressure levels. It is considered a multifactorial pathological condition. The aim of this study is to assess how variables such as age, sex, socioeconomic status, tobacco and alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress are associated with the prevalence of MS, determined using two different criteria. MATERIALS AND METHODS: This is a descriptive, cross-sectional study conducted on 24,224 Spanish workers, evaluating the association between sociodemographic variables, health habits, and stress with MS, determined using two criteria: the National Cholesterol Education Program, Adult Treatment Panel III (NCEP ATP-III), and the International Diabetes Federation (IDF). RESULTS: All the variables analyzed showed an association with the presence of MS when applying both criteria. Among them, the variables with the strongest association were age: odds ratio 5.55 (95% CI: 4.80-6.30) for MS using the NCEP ATP-III criteria and 6.71 (95% CI: 5.30-8.13) for IDF criteria; and type of job: odds ratio 3.42 (95% CI: 2.95-3.90) for NCEP ATP-III and 3.57 (95% CI: 3.12-4.03) for IDF. CONCLUSIONS: The profile of an individual at higher risk of developing MS under both criteria would be an older male, manual laborer, smoker, habitual alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high levels of stress.
  

• 
  1.

  Gordito Soler M, López-González Ángel A, Tárraga López PJ, Martínez-Almoyna Rifá E, Martorell Sánchez C, Vicente-Herrero MT, Paublini H, Ramírez-Manent JI. Association of Sociodemographic Variables and Healthy Habits with Body and Visceral Fat Values in Spanish Workers. Medicina (Kaunas, Lithuania) [Internet]. Switzerland; 2025 Jan.;61(1):150-. https://pubmed.ncbi.nlm.nih.gov/39859131

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Background and Objectives: The accumulation of fat in the body, especially visceral fat, is associated with various cardiometabolic conditions such as diabetes mellitus and fatty liver. The reasons for the accumulation of this fat are diverse. Some studies, also in the working population, have shown a clear association between sociodemographic variables and health habits with scales that assess overweight and obesity. This study aims to determine how certain sociodemographic variables, such as age, gender, and socioeconomic level, as well as certain healthy habits like physical activity and tobacco consumption, affect the levels of body and visceral fat. Materials and Methods: We conducted a descriptive and cross-sectional study involving 8590 Spanish workers. The percentage of body and visceral fat was measured using a bioimpedance analysis with a Tanita DC 430MA device. Results: Both the average values and the prevalence of elevated body and visceral fat increase with age and decrease with social class and lower levels of physical activity. These values are higher in smokers. A multivariate analysis shows that the variables most influential in increasing the risk of high levels of both body and visceral fat are age and low levels of physical activity. Conclusions: The profile of a person at high risk of having elevated body and visceral fat levels is an older male with a low socioeconomic status who smokes and leads a sedentary lifestyle.

  @article{gorditosoler2025association,
  abstract = {Background and Objectives: The accumulation of fat in the body, especially visceral fat, is associated with various cardiometabolic conditions such as diabetes mellitus and fatty liver. The reasons for the accumulation of this fat are diverse. Some studies, also in the working population, have shown a clear association between sociodemographic variables and health habits with scales that assess overweight and obesity. This study aims to determine how certain sociodemographic variables, such as age, gender, and socioeconomic level, as well as certain healthy habits like physical activity and tobacco consumption, affect the levels of body and visceral fat. Materials and Methods: We conducted a descriptive and cross-sectional study involving 8590 Spanish workers. The percentage of body and visceral fat was measured using a bioimpedance analysis with a Tanita DC 430MA device. Results: Both the average values and the prevalence of elevated body and visceral fat increase with age and decrease with social class and lower levels of physical activity. These values are higher in smokers. A multivariate analysis shows that the variables most influential in increasing the risk of high levels of both body and visceral fat are age and low levels of physical activity. Conclusions: The profile of a person at high risk of having elevated body and visceral fat levels is an older male with a low socioeconomic status who smokes and leads a sedentary lifestyle.},
  address = {Switzerland},
  author = {Gordito Soler, María and López-González, Ángel Arturo and Tárraga López, Pedro Juan and Martínez-Almoyna Rifá, Emilio and Martorell Sánchez, Cristina and Vicente-Herrero, María Teófila and Paublini, Hernan and Ramírez-Manent, José Ignacio},
  journal = {Medicina (Kaunas, Lithuania)},
  keywords = {grapp-caib},
  month = {jan},
  number = 1,
  pages = {150--},
  title = {Association of Sociodemographic Variables and Healthy Habits with Body and Visceral Fat Values in Spanish Workers},
  volume = 61,
  year = 2025
  }
  

  %0 Journal Article
  %1 gorditosoler2025association
  %A Gordito Soler, María
  %A López-González, Ángel Arturo
  %A Tárraga López, Pedro Juan
  %A Martínez-Almoyna Rifá, Emilio
  %A Martorell Sánchez, Cristina
  %A Vicente-Herrero, María Teófila
  %A Paublini, Hernan
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Medicina (Kaunas, Lithuania)
  %N 1
  %P 150--
  %R 10.3390/medicina61010150
  %T Association of Sociodemographic Variables and Healthy Habits with Body and Visceral Fat Values in Spanish Workers
  %U https://pubmed.ncbi.nlm.nih.gov/39859131
  %V 61
  %X Background and Objectives: The accumulation of fat in the body, especially visceral fat, is associated with various cardiometabolic conditions such as diabetes mellitus and fatty liver. The reasons for the accumulation of this fat are diverse. Some studies, also in the working population, have shown a clear association between sociodemographic variables and health habits with scales that assess overweight and obesity. This study aims to determine how certain sociodemographic variables, such as age, gender, and socioeconomic level, as well as certain healthy habits like physical activity and tobacco consumption, affect the levels of body and visceral fat. Materials and Methods: We conducted a descriptive and cross-sectional study involving 8590 Spanish workers. The percentage of body and visceral fat was measured using a bioimpedance analysis with a Tanita DC 430MA device. Results: Both the average values and the prevalence of elevated body and visceral fat increase with age and decrease with social class and lower levels of physical activity. These values are higher in smokers. A multivariate analysis shows that the variables most influential in increasing the risk of high levels of both body and visceral fat are age and low levels of physical activity. Conclusions: The profile of a person at high risk of having elevated body and visceral fat levels is an older male with a low socioeconomic status who smokes and leads a sedentary lifestyle.
  

• 
  1.

  López-González Ángel A, Martínez-Almoyna Rifá E, Oliveira HP, Sánchez CM, Tárraga López PJ, Ramírez-Manent JI. Association Between Sociodemographic Variables, Healthy Habits, and Stress with Risk Scales for Liver Disease Associated with Metabolic Dysfunction. Life (Basel, Switzerland) [Internet]. Switzerland; 2025 Jan.;15(1):116-. https://pubmed.ncbi.nlm.nih.gov/39860055

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common cause of chronic liver disease worldwide, with a multifactorial etiology. This study aims to evaluate the associations between various sociodemographic variables, healthy habits, and stress with risk scale values for MAFLD. MATERIALS AND METHODS: A descriptive, cross-sectional study was conducted on 16,708 Spanish workers to assess how sociodemographic variables (age, gender, and socioeconomic status), healthy habits (smoking, Mediterranean diet adherence, and physical activity), and stress correlate with values from three MAFLD risk scales: fatty liver index (FLI), hepatic steatosis index (HSI), and lipid accumulation product (LAP). RESULTS: All analyzed variables were associated with the values of the three MAFLD risk scales. Among them, the variables showing the strongest associations (represented by odds ratio values) were age and physical activity. CONCLUSIONS: The profile of an individual at higher risk of elevated MAFLD risk scale values is a male, aged 50 or older, belonging to lower socioeconomic levels (manual laborers), a smoker, sedentary, with low adherence to the Mediterranean diet, and with high stress scale scores.

  @article{lopezgonzalez2025association,
  abstract = {Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common cause of chronic liver disease worldwide, with a multifactorial etiology. This study aims to evaluate the associations between various sociodemographic variables, healthy habits, and stress with risk scale values for MAFLD. MATERIALS AND METHODS: A descriptive, cross-sectional study was conducted on 16,708 Spanish workers to assess how sociodemographic variables (age, gender, and socioeconomic status), healthy habits (smoking, Mediterranean diet adherence, and physical activity), and stress correlate with values from three MAFLD risk scales: fatty liver index (FLI), hepatic steatosis index (HSI), and lipid accumulation product (LAP). RESULTS: All analyzed variables were associated with the values of the three MAFLD risk scales. Among them, the variables showing the strongest associations (represented by odds ratio values) were age and physical activity. CONCLUSIONS: The profile of an individual at higher risk of elevated MAFLD risk scale values is a male, aged 50 or older, belonging to lower socioeconomic levels (manual laborers), a smoker, sedentary, with low adherence to the Mediterranean diet, and with high stress scale scores.},
  address = {Switzerland},
  author = {López-González, Ángel Arturo and Martínez-Almoyna Rifá, Emilio and Oliveira, Hernán Paublini and Sánchez, Cristina Martorell and Tárraga López, Pedro Juan and Ramírez-Manent, José Ignacio},
  journal = {Life (Basel, Switzerland)},
  keywords = {grapp-caib},
  month = {jan},
  number = 1,
  pages = {116--},
  title = {Association Between Sociodemographic Variables, Healthy Habits, and Stress with Risk Scales for Liver Disease Associated with Metabolic Dysfunction},
  volume = 15,
  year = 2025
  }
  

  %0 Journal Article
  %1 lopezgonzalez2025association
  %A López-González, Ángel Arturo
  %A Martínez-Almoyna Rifá, Emilio
  %A Oliveira, Hernán Paublini
  %A Sánchez, Cristina Martorell
  %A Tárraga López, Pedro Juan
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Life (Basel, Switzerland)
  %N 1
  %P 116--
  %R 10.3390/life15010116
  %T Association Between Sociodemographic Variables, Healthy Habits, and Stress with Risk Scales for Liver Disease Associated with Metabolic Dysfunction
  %U https://pubmed.ncbi.nlm.nih.gov/39860055
  %V 15
  %X Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common cause of chronic liver disease worldwide, with a multifactorial etiology. This study aims to evaluate the associations between various sociodemographic variables, healthy habits, and stress with risk scale values for MAFLD. MATERIALS AND METHODS: A descriptive, cross-sectional study was conducted on 16,708 Spanish workers to assess how sociodemographic variables (age, gender, and socioeconomic status), healthy habits (smoking, Mediterranean diet adherence, and physical activity), and stress correlate with values from three MAFLD risk scales: fatty liver index (FLI), hepatic steatosis index (HSI), and lipid accumulation product (LAP). RESULTS: All analyzed variables were associated with the values of the three MAFLD risk scales. Among them, the variables showing the strongest associations (represented by odds ratio values) were age and physical activity. CONCLUSIONS: The profile of an individual at higher risk of elevated MAFLD risk scale values is a male, aged 50 or older, belonging to lower socioeconomic levels (manual laborers), a smoker, sedentary, with low adherence to the Mediterranean diet, and with high stress scale scores.
  

• 
  1.

  López-González Ángel A, Martínez-Almoyna Rifá E, Paublini Oliveira H, Martorell Sánchez C, Tárraga López PJ, Ramírez-Manent JI. Association between sociodemographic variables, healthy habits and stress with diabesity. Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis [Internet]. Spain; 2025 Jan.;:500754-. https://pubmed.ncbi.nlm.nih.gov/39824668

  AbstractURLBibTeXEndNoteDOIBibSonomy

  INTRODUCTION: Diabesity is a pathological condition that combines obesity and type 2 diabetes in the same individual. Due to the current rise in both conditions, the prevalence of diabesity is increasing worldwide. Its etiology is known to be multifactorial; therefore, the aim of this study is to understand how diabesity is associated with various sociodemographic variables, healthy habits, and stress. MATERIALS AND METHODS: A descriptive, cross-sectional study was conducted on 24,224 Spanish workers to evaluate the association between diabesity and various factors such as age, gender, socioeconomic status, smoking, alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress. The criteria used to define diabesity included body mass index (BMI), body fat (BF), and visceral fat (VF). RESULTS: All the aforementioned variables were found to be associated with diabesity. The highest odds ratios (OR) were observed for age, with values ranging from 5.57 (95% CI: 4.48-6.67) when BF was used as the diabesity criterion to 6.89 (95% CI: 5.60-8.19) when VF was the criterion. Similarly, elevated ORs were observed for male gender, with ORs of 6.77 (95% CI: 5.31-8.24) for VF and 3.34 (95% CI: 2.77-3.94) for BF. CONCLUSIONS: In our study, the profile of a person at highest risk of diabesity is a man over 50 years old from a lower socioeconomic status, who is a smoker, regular alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high stress levels.

  @article{lopezgonzalez2025association,
  abstract = {INTRODUCTION: Diabesity is a pathological condition that combines obesity and type 2 diabetes in the same individual. Due to the current rise in both conditions, the prevalence of diabesity is increasing worldwide. Its etiology is known to be multifactorial; therefore, the aim of this study is to understand how diabesity is associated with various sociodemographic variables, healthy habits, and stress. MATERIALS AND METHODS: A descriptive, cross-sectional study was conducted on 24,224 Spanish workers to evaluate the association between diabesity and various factors such as age, gender, socioeconomic status, smoking, alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress. The criteria used to define diabesity included body mass index (BMI), body fat (BF), and visceral fat (VF). RESULTS: All the aforementioned variables were found to be associated with diabesity. The highest odds ratios (OR) were observed for age, with values ranging from 5.57 (95% CI: 4.48-6.67) when BF was used as the diabesity criterion to 6.89 (95% CI: 5.60-8.19) when VF was the criterion. Similarly, elevated ORs were observed for male gender, with ORs of 6.77 (95% CI: 5.31-8.24) for VF and 3.34 (95% CI: 2.77-3.94) for BF. CONCLUSIONS: In our study, the profile of a person at highest risk of diabesity is a man over 50 years old from a lower socioeconomic status, who is a smoker, regular alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high stress levels.},
  address = {Spain},
  author = {López-González, Ángel Arturo and Martínez-Almoyna Rifá, Emilio and Paublini Oliveira, Hernán and Martorell Sánchez, Cristina and Tárraga López, Pedro Juan and Ramírez-Manent, José Ignacio},
  journal = {Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis},
  keywords = {grapp-caib},
  month = {jan},
  pages = {500754--500754},
  title = {Association between sociodemographic variables, healthy habits and stress with diabesity},
  year = 2025
  }
  

  %0 Journal Article
  %1 lopezgonzalez2025association
  %A López-González, Ángel Arturo
  %A Martínez-Almoyna Rifá, Emilio
  %A Paublini Oliveira, Hernán
  %A Martorell Sánchez, Cristina
  %A Tárraga López, Pedro Juan
  %A Ramírez-Manent, José Ignacio
  %C Spain
  %D 2025
  %J Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
  %P 500754--500754
  %R 10.1016/j.arteri.2024.500754
  %T Association between sociodemographic variables, healthy habits and stress with diabesity
  %U https://pubmed.ncbi.nlm.nih.gov/39824668
  %X INTRODUCTION: Diabesity is a pathological condition that combines obesity and type 2 diabetes in the same individual. Due to the current rise in both conditions, the prevalence of diabesity is increasing worldwide. Its etiology is known to be multifactorial; therefore, the aim of this study is to understand how diabesity is associated with various sociodemographic variables, healthy habits, and stress. MATERIALS AND METHODS: A descriptive, cross-sectional study was conducted on 24,224 Spanish workers to evaluate the association between diabesity and various factors such as age, gender, socioeconomic status, smoking, alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress. The criteria used to define diabesity included body mass index (BMI), body fat (BF), and visceral fat (VF). RESULTS: All the aforementioned variables were found to be associated with diabesity. The highest odds ratios (OR) were observed for age, with values ranging from 5.57 (95% CI: 4.48-6.67) when BF was used as the diabesity criterion to 6.89 (95% CI: 5.60-8.19) when VF was the criterion. Similarly, elevated ORs were observed for male gender, with ORs of 6.77 (95% CI: 5.31-8.24) for VF and 3.34 (95% CI: 2.77-3.94) for BF. CONCLUSIONS: In our study, the profile of a person at highest risk of diabesity is a man over 50 years old from a lower socioeconomic status, who is a smoker, regular alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high stress levels.
  

• 
  1.

  Bescos R, Gallardo-Alfaro L, Ashor A, Rizzolo-Brime L, Siervo M, Casas-Agustench P. Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis. Free radical biology & medicine [Internet]. United States; 2025 Jan.;226:70-83. https://pubmed.ncbi.nlm.nih.gov/39522567

  AbstractURLBibTeXEndNoteDOIBibSonomy

  In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO(3)(-)) and nitrite (NO(2)(-)) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO(3)(-) and NO(2)(-) using the chemiluminescence technique, were included. Mean plasma NO(3)(-) and NO(2)(-) concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO(3)(-) and NO(2)(-) concentrations in individuals with cardiometabolic risk (NO(3)(-): 21.2 μmol/L; 95 % CI, 13.4-29.0; NO(2)(-): 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO(3)(-): 33.9 μmol/L; 95 % CI, 29.9-37.9; NO(2)(-): 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO(3)(-): 43.0 μmol/L; 95 % CI, 13.2-72.9; NO(2)(-): 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO(3)(-) and NO(2)(-) concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO(3)(-), but no NO(2)(-), concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO(3)(-) and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO(3)(-) and NO(2)(-) concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO(3)(-) showed a significant positive association with DBP.

  @article{bescos2025nitrate,
  abstract = {In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO(3)(-)) and nitrite (NO(2)(-)) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO(3)(-) and NO(2)(-) using the chemiluminescence technique, were included. Mean plasma NO(3)(-) and NO(2)(-) concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO(3)(-) and NO(2)(-) concentrations in individuals with cardiometabolic risk (NO(3)(-): 21.2 μmol/L; 95 % CI, 13.4-29.0; NO(2)(-): 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO(3)(-): 33.9 μmol/L; 95 % CI, 29.9-37.9; NO(2)(-): 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO(3)(-): 43.0 μmol/L; 95 % CI, 13.2-72.9; NO(2)(-): 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO(3)(-) and NO(2)(-) concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO(3)(-), but no NO(2)(-), concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO(3)(-) and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO(3)(-) and NO(2)(-) concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO(3)(-) showed a significant positive association with DBP.},
  address = {United States},
  author = {Bescos, Raul and Gallardo-Alfaro, Laura and Ashor, Ammar and Rizzolo-Brime, Lucia and Siervo, Mario and Casas-Agustench, Patricia},
  journal = {Free radical biology & medicine},
  keywords = {grapp-caib},
  month = {jan},
  pages = {70--83},
  title = {Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis},
  volume = 226,
  year = 2025
  }
  

  %0 Journal Article
  %1 bescos2025nitrate
  %A Bescos, Raul
  %A Gallardo-Alfaro, Laura
  %A Ashor, Ammar
  %A Rizzolo-Brime, Lucia
  %A Siervo, Mario
  %A Casas-Agustench, Patricia
  %C United States
  %D 2025
  %J Free radical biology & medicine
  %P 70--83
  %R 10.1016/j.freeradbiomed.2024.11.010
  %T Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis
  %U https://pubmed.ncbi.nlm.nih.gov/39522567
  %V 226
  %X In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO(3)(-)) and nitrite (NO(2)(-)) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO(3)(-) and NO(2)(-) using the chemiluminescence technique, were included. Mean plasma NO(3)(-) and NO(2)(-) concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO(3)(-) and NO(2)(-) concentrations in individuals with cardiometabolic risk (NO(3)(-): 21.2 μmol/L; 95 % CI, 13.4-29.0; NO(2)(-): 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO(3)(-): 33.9 μmol/L; 95 % CI, 29.9-37.9; NO(2)(-): 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO(3)(-): 43.0 μmol/L; 95 % CI, 13.2-72.9; NO(2)(-): 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO(3)(-) and NO(2)(-) concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO(3)(-), but no NO(2)(-), concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO(3)(-) and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO(3)(-) and NO(2)(-) concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO(3)(-) showed a significant positive association with DBP.
  

• 
  1.

  Marina Arroyo M, Ramírez Gallegos I, Paublini H, López-González Ángel A, Tárraga López PJ, Martorell Sánchez C, Sastre-Alzamora T, Ramírez-Manent JI. Usefulness of the Córdoba Equation for Estimating Body Fat When Determining the Level of Risk of Developing Diabetes Type 2 or Prediabetes. Medicina (Kaunas, Lithuania) [Internet]. Switzerland; 2025 Mar.;61(4):613-. https://pubmed.ncbi.nlm.nih.gov/40282904

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Background and Objectives: Type 2 diabetes (T2D) and prediabetes represent major global health concerns, with obesity being a key risk factor. However, recent evidence suggests that the adipose tissue composition and distribution play a more critical role in metabolic dysfunction than the total body weight or body mass index (BMI). This study evaluates the predictive capacity of the Córdoba Equation for Estimating Body Fat (ECORE-BF) for identifying individuals at high risk of developing T2D and prediabetes. Materials and Methods: A cross-sectional study was carried out involving 418,343 Spanish workers. Body fat percentage was estimated using the ECORE-BF equation, and diabetes risk was assessed using validated predictive models, including the Finnish Diabetes Risk Score (FINDRISC), QDiabetes score (QD-score), and others. The discriminatory power of ECORE-BF in predicting T2D and prediabetes was assessed using receiver operating characteristic (ROC) curve analysis. Results: ECORE-BF showed a strong correlation with high-risk classifications across all diabetes risk scales. The area under the ROC curve (AUC) exceeded 0.95 for both men and women, demonstrating high predictive accuracy. Conclusions: Adipose tissue distribution, particularly visceral adiposity, is a central factor in metabolic dysfunction. ECORE-BF provides a cost-effective alternative for large-scale T2D and prediabetes risk assessment. Future research should explore the impact of visceral adipose tissue reduction on diabetes prevention and the integration of estimation scales into clinical and public health strategies.

  @article{marinaarroyo2025usefulness,
  abstract = {Background and Objectives: Type 2 diabetes (T2D) and prediabetes represent major global health concerns, with obesity being a key risk factor. However, recent evidence suggests that the adipose tissue composition and distribution play a more critical role in metabolic dysfunction than the total body weight or body mass index (BMI). This study evaluates the predictive capacity of the Córdoba Equation for Estimating Body Fat (ECORE-BF) for identifying individuals at high risk of developing T2D and prediabetes. Materials and Methods: A cross-sectional study was carried out involving 418,343 Spanish workers. Body fat percentage was estimated using the ECORE-BF equation, and diabetes risk was assessed using validated predictive models, including the Finnish Diabetes Risk Score (FINDRISC), QDiabetes score (QD-score), and others. The discriminatory power of ECORE-BF in predicting T2D and prediabetes was assessed using receiver operating characteristic (ROC) curve analysis. Results: ECORE-BF showed a strong correlation with high-risk classifications across all diabetes risk scales. The area under the ROC curve (AUC) exceeded 0.95 for both men and women, demonstrating high predictive accuracy. Conclusions: Adipose tissue distribution, particularly visceral adiposity, is a central factor in metabolic dysfunction. ECORE-BF provides a cost-effective alternative for large-scale T2D and prediabetes risk assessment. Future research should explore the impact of visceral adipose tissue reduction on diabetes prevention and the integration of estimation scales into clinical and public health strategies.},
  address = {Switzerland},
  author = {Marina Arroyo, Marta and Ramírez Gallegos, Ignacio and Paublini, Hernán and López-González, Ángel Arturo and Tárraga López, Pedro J and Martorell Sánchez, Cristina and Sastre-Alzamora, Tomás and Ramírez-Manent, José Ignacio},
  journal = {Medicina (Kaunas, Lithuania)},
  keywords = {grapp-caib},
  month = {mar},
  number = 4,
  pages = {613--},
  title = {Usefulness of the Córdoba Equation for Estimating Body Fat When Determining the Level of Risk of Developing Diabetes Type 2 or Prediabetes},
  volume = 61,
  year = 2025
  }
  

  %0 Journal Article
  %1 marinaarroyo2025usefulness
  %A Marina Arroyo, Marta
  %A Ramírez Gallegos, Ignacio
  %A Paublini, Hernán
  %A López-González, Ángel Arturo
  %A Tárraga López, Pedro J
  %A Martorell Sánchez, Cristina
  %A Sastre-Alzamora, Tomás
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2025
  %J Medicina (Kaunas, Lithuania)
  %N 4
  %P 613--
  %R 10.3390/medicina61040613
  %T Usefulness of the Córdoba Equation for Estimating Body Fat When Determining the Level of Risk of Developing Diabetes Type 2 or Prediabetes
  %U https://pubmed.ncbi.nlm.nih.gov/40282904
  %V 61
  %X Background and Objectives: Type 2 diabetes (T2D) and prediabetes represent major global health concerns, with obesity being a key risk factor. However, recent evidence suggests that the adipose tissue composition and distribution play a more critical role in metabolic dysfunction than the total body weight or body mass index (BMI). This study evaluates the predictive capacity of the Córdoba Equation for Estimating Body Fat (ECORE-BF) for identifying individuals at high risk of developing T2D and prediabetes. Materials and Methods: A cross-sectional study was carried out involving 418,343 Spanish workers. Body fat percentage was estimated using the ECORE-BF equation, and diabetes risk was assessed using validated predictive models, including the Finnish Diabetes Risk Score (FINDRISC), QDiabetes score (QD-score), and others. The discriminatory power of ECORE-BF in predicting T2D and prediabetes was assessed using receiver operating characteristic (ROC) curve analysis. Results: ECORE-BF showed a strong correlation with high-risk classifications across all diabetes risk scales. The area under the ROC curve (AUC) exceeded 0.95 for both men and women, demonstrating high predictive accuracy. Conclusions: Adipose tissue distribution, particularly visceral adiposity, is a central factor in metabolic dysfunction. ECORE-BF provides a cost-effective alternative for large-scale T2D and prediabetes risk assessment. Future research should explore the impact of visceral adipose tissue reduction on diabetes prevention and the integration of estimation scales into clinical and public health strategies.
  

2024

• 
  1.

  Ripoll J, Chela X, Briones-VozmedianoFiol-de Roque EM, Zamanillo-Campos R, Ricci-Cabello I, Llobera J, Calafat-Villalonga C, Serrano-Ripoll MJ. Impact of COVID-19 on mental health of health care workers in Spain: a mix-methods study. BMC public health [Internet]. England; 2024 Feb.;24(1):463-. https://pubmed.ncbi.nlm.nih.gov/38355471

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Spain's lockdown measures couldn't prevent the severe impact of the COVID-19 first wave, leading to high infections, deaths, and strain on healthcare workers (HCWs). This study aimed to explore the mental health impact on HCWs in the Balearic Islands during the initial months of the pandemic, the influencing factors, and the experiences of those in a COVID-19 environment. METHODS: Using a mixed-methods approach, the study encompassed quantitative and qualitative elements. Cross-sectional survey data from April to June 2020 comprised HCWs who were emailed invitations. The survey covered demographics, work, clinical and COVID-19 variables, along with psychological distress and PTSD symptoms, using validated measures. Additionally, semi-structured interviews with HCWs offered qualitative insights. RESULTS: Three hundred thirty-six HCWs averaging 46.8 years, mainly women (79.2%), primarily nurses in primary care with over 10 years of experience. Anxiety symptoms were reported by 28.8%, 65.1% noted worsened sleep quality, and 27.7% increased psychoactive drug usage. Psychological distress affected 55.2%, while 27.9% exhibited PTSD symptoms. Gender, age, experience, COVID-19 patient contact, and workload correlated with distress, PTSD symptoms, sleep quality, and psychoactive drug usage. Interviews uncovered discomfort sources, such as fear of infection and lack of control, leading to coping strategies like information avoidance and seeking support. LIMITATIONS: Static cross-sectional design, non-probabilistic sample, and telephone interviews affecting non-verbal cues, with interviews conducted during early pandemic lockdown. CONCLUSIONS: HCWs faced significant psychological distress during the pandemic's first wave, underscoring the necessity for robust support and resources to counteract its impact on mental health.

  @article{ripoll2024impact,
  abstract = {BACKGROUND: Spain's lockdown measures couldn't prevent the severe impact of the COVID-19 first wave, leading to high infections, deaths, and strain on healthcare workers (HCWs). This study aimed to explore the mental health impact on HCWs in the Balearic Islands during the initial months of the pandemic, the influencing factors, and the experiences of those in a COVID-19 environment. METHODS: Using a mixed-methods approach, the study encompassed quantitative and qualitative elements. Cross-sectional survey data from April to June 2020 comprised HCWs who were emailed invitations. The survey covered demographics, work, clinical and COVID-19 variables, along with psychological distress and PTSD symptoms, using validated measures. Additionally, semi-structured interviews with HCWs offered qualitative insights. RESULTS: Three hundred thirty-six HCWs averaging 46.8 years, mainly women (79.2%), primarily nurses in primary care with over 10 years of experience. Anxiety symptoms were reported by 28.8%, 65.1% noted worsened sleep quality, and 27.7% increased psychoactive drug usage. Psychological distress affected 55.2%, while 27.9% exhibited PTSD symptoms. Gender, age, experience, COVID-19 patient contact, and workload correlated with distress, PTSD symptoms, sleep quality, and psychoactive drug usage. Interviews uncovered discomfort sources, such as fear of infection and lack of control, leading to coping strategies like information avoidance and seeking support. LIMITATIONS: Static cross-sectional design, non-probabilistic sample, and telephone interviews affecting non-verbal cues, with interviews conducted during early pandemic lockdown. CONCLUSIONS: HCWs faced significant psychological distress during the pandemic's first wave, underscoring the necessity for robust support and resources to counteract its impact on mental health.},
  address = {England},
  author = {Ripoll, J and Chela, X and Briones-VozmedianoFiol-de Roque, E Ma and Zamanillo-Campos, R and Ricci-Cabello, I and Llobera, J and Calafat-Villalonga, C and Serrano-Ripoll, M J},
  journal = {BMC public health},
  keywords = {evisap grapp-caib},
  month = {feb},
  number = 1,
  pages = {463--463},
  title = {Impact of COVID-19 on mental health of health care workers in Spain: a mix-methods study},
  volume = 24,
  year = 2024
  }
  

  %0 Journal Article
  %1 ripoll2024impact
  %A Ripoll, J
  %A Chela, X
  %A Briones-VozmedianoFiol-de Roque, E Ma
  %A Zamanillo-Campos, R
  %A Ricci-Cabello, I
  %A Llobera, J
  %A Calafat-Villalonga, C
  %A Serrano-Ripoll, M J
  %C England
  %D 2024
  %J BMC public health
  %N 1
  %P 463--463
  %R 10.1186/s12889-024-17979-z
  %T Impact of COVID-19 on mental health of health care workers in Spain: a mix-methods study
  %U https://pubmed.ncbi.nlm.nih.gov/38355471
  %V 24
  %X BACKGROUND: Spain's lockdown measures couldn't prevent the severe impact of the COVID-19 first wave, leading to high infections, deaths, and strain on healthcare workers (HCWs). This study aimed to explore the mental health impact on HCWs in the Balearic Islands during the initial months of the pandemic, the influencing factors, and the experiences of those in a COVID-19 environment. METHODS: Using a mixed-methods approach, the study encompassed quantitative and qualitative elements. Cross-sectional survey data from April to June 2020 comprised HCWs who were emailed invitations. The survey covered demographics, work, clinical and COVID-19 variables, along with psychological distress and PTSD symptoms, using validated measures. Additionally, semi-structured interviews with HCWs offered qualitative insights. RESULTS: Three hundred thirty-six HCWs averaging 46.8 years, mainly women (79.2%), primarily nurses in primary care with over 10 years of experience. Anxiety symptoms were reported by 28.8%, 65.1% noted worsened sleep quality, and 27.7% increased psychoactive drug usage. Psychological distress affected 55.2%, while 27.9% exhibited PTSD symptoms. Gender, age, experience, COVID-19 patient contact, and workload correlated with distress, PTSD symptoms, sleep quality, and psychoactive drug usage. Interviews uncovered discomfort sources, such as fear of infection and lack of control, leading to coping strategies like information avoidance and seeking support. LIMITATIONS: Static cross-sectional design, non-probabilistic sample, and telephone interviews affecting non-verbal cues, with interviews conducted during early pandemic lockdown. CONCLUSIONS: HCWs faced significant psychological distress during the pandemic's first wave, underscoring the necessity for robust support and resources to counteract its impact on mental health.
  

• 
  1.

  Torrens-Darder MDM, Torrens-Darder I, Gonzalez Torrente S, Vicens C, Leiva A, Pizá-Portell MR, Esteva Arrom AL, Lorente P, Serrano-Ripoll M-J, Vidal-Thomas MC, Miralles-Xamena J, Ramírez Manent JI, Esteva M. Evaluation of the effectiveness of cognitive-behavioural therapy for insomnia delivered by nurses and physicians for patients in primary care (the NPD study): protocol for a cluster randomised controlled trial. BMJ open [Internet]. England; 2024 Oct.;14(10):e089158-e089158. https://pubmed.ncbi.nlm.nih.gov/39461854

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: Insomnia is the most common sleep disorder, and it adversely impacts daily living and increases the risk of chronic and acute health problems. Of the few individuals who seek treatment for insomnia, most pursue help in primary care settings. The management of insomnia most commonly focuses on the prescription of hypnotics and sleep hygiene recommendations, although these are not the most effective treatments. Conversely, cognitive-behavioural therapy for insomnia (CBT-i), which is considered to be the first-line treatment for persistent insomnia, is seldom prescribed by primary care physicians (PCPs) or primary care nurses (PCNs). The hesitancy of these professionals to provide CBT-i is mainly attributed to their heavy workloads and the difficulties in acquiring the skills needed to administer this intervention. METHODS AND ANALYSIS: A two-arm cluster-randomised study (in which patients are assigned to a PCP or PCN) will be conducted in primary health centres of Majorca Island (Spain). A total of 206 patients will be recruited. Healthcare professionals will be allocated to the intervention or control group in a 1:1 ratio. The intervention group will receive CBT-i and the control group will receive usual care. We will include patients with Insomnia Severity Index scores of 8 or more who also report that insomnia interferes with daily functioning or is noticeable to others. The CBT-i will consist of four individual structured sessions, three in person (20 min each) and one by telephone (10 min) that are administered at intervals of 2-3 weeks. An additional session will be provided for patients taking hypnotic medications. The primary outcome measure is the decrease in sleep latency, which will be measured with the Pittsburg Sleep Quality index at 6 months and 12 months. ETHICS AND DISSEMINATION: This project was approved by the Ethical Committee of the Balearic Islands (IB 4604/21 PI) and the Primary Care Research Committee of the Department of Majorca Primary Care (PI19/24). All participants are required to provide written informed consent and no study-related procedures will be performed until consent is obtained. The trial results will be published in peer-reviewed journals and presented at conferences. TRIAL REGISTRATION NUMBER: ISRCTN10144646.

  @article{torrensdarder2024evaluation,
  abstract = {INTRODUCTION: Insomnia is the most common sleep disorder, and it adversely impacts daily living and increases the risk of chronic and acute health problems. Of the few individuals who seek treatment for insomnia, most pursue help in primary care settings. The management of insomnia most commonly focuses on the prescription of hypnotics and sleep hygiene recommendations, although these are not the most effective treatments. Conversely, cognitive-behavioural therapy for insomnia (CBT-i), which is considered to be the first-line treatment for persistent insomnia, is seldom prescribed by primary care physicians (PCPs) or primary care nurses (PCNs). The hesitancy of these professionals to provide CBT-i is mainly attributed to their heavy workloads and the difficulties in acquiring the skills needed to administer this intervention. METHODS AND ANALYSIS: A two-arm cluster-randomised study (in which patients are assigned to a PCP or PCN) will be conducted in primary health centres of Majorca Island (Spain). A total of 206 patients will be recruited. Healthcare professionals will be allocated to the intervention or control group in a 1:1 ratio. The intervention group will receive CBT-i and the control group will receive usual care. We will include patients with Insomnia Severity Index scores of 8 or more who also report that insomnia interferes with daily functioning or is noticeable to others. The CBT-i will consist of four individual structured sessions, three in person (20 min each) and one by telephone (10 min) that are administered at intervals of 2-3 weeks. An additional session will be provided for patients taking hypnotic medications. The primary outcome measure is the decrease in sleep latency, which will be measured with the Pittsburg Sleep Quality index at 6 months and 12 months. ETHICS AND DISSEMINATION: This project was approved by the Ethical Committee of the Balearic Islands (IB 4604/21 PI) and the Primary Care Research Committee of the Department of Majorca Primary Care (PI19/24). All participants are required to provide written informed consent and no study-related procedures will be performed until consent is obtained. The trial results will be published in peer-reviewed journals and presented at conferences. TRIAL REGISTRATION NUMBER: ISRCTN10144646.},
  address = {England},
  author = {Torrens-Darder, Maria Del Mar and Torrens-Darder, Isabel and Gonzalez Torrente, Susana and Vicens, Caterina and Leiva, Alfonso and Pizá-Portell, Maria Rosa and Esteva Arrom, Apol Lonia and Lorente, Patricia and Serrano-Ripoll, Maria-Jesus and Vidal-Thomas, Maria Clara and Miralles-Xamena, Jerónima and Ramírez Manent, José Ignacio and Esteva, Magdalena},
  journal = {BMJ open},
  keywords = {grapp-caib},
  month = {oct},
  number = 10,
  pages = {e089158--e089158},
  title = {Evaluation of the effectiveness of cognitive-behavioural therapy for insomnia delivered by nurses and physicians for patients in primary care (the NPD study): protocol for a cluster randomised controlled trial},
  volume = 14,
  year = 2024
  }
  

  %0 Journal Article
  %1 torrensdarder2024evaluation
  %A Torrens-Darder, Maria Del Mar
  %A Torrens-Darder, Isabel
  %A Gonzalez Torrente, Susana
  %A Vicens, Caterina
  %A Leiva, Alfonso
  %A Pizá-Portell, Maria Rosa
  %A Esteva Arrom, Apol Lonia
  %A Lorente, Patricia
  %A Serrano-Ripoll, Maria-Jesus
  %A Vidal-Thomas, Maria Clara
  %A Miralles-Xamena, Jerónima
  %A Ramírez Manent, José Ignacio
  %A Esteva, Magdalena
  %C England
  %D 2024
  %J BMJ open
  %N 10
  %P e089158--e089158
  %R 10.1136/bmjopen-2024-089158
  %T Evaluation of the effectiveness of cognitive-behavioural therapy for insomnia delivered by nurses and physicians for patients in primary care (the NPD study): protocol for a cluster randomised controlled trial
  %U https://pubmed.ncbi.nlm.nih.gov/39461854
  %V 14
  %X INTRODUCTION: Insomnia is the most common sleep disorder, and it adversely impacts daily living and increases the risk of chronic and acute health problems. Of the few individuals who seek treatment for insomnia, most pursue help in primary care settings. The management of insomnia most commonly focuses on the prescription of hypnotics and sleep hygiene recommendations, although these are not the most effective treatments. Conversely, cognitive-behavioural therapy for insomnia (CBT-i), which is considered to be the first-line treatment for persistent insomnia, is seldom prescribed by primary care physicians (PCPs) or primary care nurses (PCNs). The hesitancy of these professionals to provide CBT-i is mainly attributed to their heavy workloads and the difficulties in acquiring the skills needed to administer this intervention. METHODS AND ANALYSIS: A two-arm cluster-randomised study (in which patients are assigned to a PCP or PCN) will be conducted in primary health centres of Majorca Island (Spain). A total of 206 patients will be recruited. Healthcare professionals will be allocated to the intervention or control group in a 1:1 ratio. The intervention group will receive CBT-i and the control group will receive usual care. We will include patients with Insomnia Severity Index scores of 8 or more who also report that insomnia interferes with daily functioning or is noticeable to others. The CBT-i will consist of four individual structured sessions, three in person (20 min each) and one by telephone (10 min) that are administered at intervals of 2-3 weeks. An additional session will be provided for patients taking hypnotic medications. The primary outcome measure is the decrease in sleep latency, which will be measured with the Pittsburg Sleep Quality index at 6 months and 12 months. ETHICS AND DISSEMINATION: This project was approved by the Ethical Committee of the Balearic Islands (IB 4604/21 PI) and the Primary Care Research Committee of the Department of Majorca Primary Care (PI19/24). All participants are required to provide written informed consent and no study-related procedures will be performed until consent is obtained. The trial results will be published in peer-reviewed journals and presented at conferences. TRIAL REGISTRATION NUMBER: ISRCTN10144646.
  

• 
  1.

  Sánchez-Rodríguez C, Capitán-Moyano L, Malih N, Yáñez AM, Bennasar-Veny M, Velasco-Roldán O, Bulilete O, Llobera-Canaves J. Prevalence of musculoskeletal disorders among hotel housekeepers and cleaners: A systematic review with meta-analysis. Musculoskeletal science & practice [Internet]. Netherlands; 2024 Feb.;69:102890-. https://pubmed.ncbi.nlm.nih.gov/38081106

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUND: Musculoskeletal disorders (MSD) are among the most frequent and costly occupational health problems with a rising prevalence globally. OBJECTIVE: This systematic review with meta-analysis was conducted to know and evaluate the prevalence of MSD by anatomic location among hotel housekeepers (HHs) and cleaners. METHODS: Electronic searches were conducted in PubMed, Web of Science, Scopus, Dialnet Plus, PEDro and Cochrane Database for Systematic Reviews using a search strategy to identify cross-sectional studies reporting on the prevalence of MSD in HHs or cleaners. The risk of bias was assessed with Joanna Briggs Institute tool for systematic reviews. A random-effects model was used in the meta-analysis. RESULTS: Nineteen studies were included in the systematic review, nine of them in the meta-analysis (n = 2299). The study sample sizes ranged from 24 to 1043 participants. The Standardized Nordic Musculoskeletal Questionnaire was the most common tool used to assess MSD among both HHs and cleaners (9/19 of the included studies). The three most affected anatomic locations were the low back 53.9% (95% CI: 43.3-64.6), shoulders 41.4% (95% CI: 27.1-55.8), and wrists/hands 40.1% (95% CI: 24.5-55.7). CONCLUSIONS: HHs and cleaners have a high prevalence of MSD. Low back pain is the most prevalent MSD among both HHs and cleaners affecting up to one of two people.

  @article{sanchezrodriguez2024prevalence,
  abstract = {BACKGROUND: Musculoskeletal disorders (MSD) are among the most frequent and costly occupational health problems with a rising prevalence globally. OBJECTIVE: This systematic review with meta-analysis was conducted to know and evaluate the prevalence of MSD by anatomic location among hotel housekeepers (HHs) and cleaners. METHODS: Electronic searches were conducted in PubMed, Web of Science, Scopus, Dialnet Plus, PEDro and Cochrane Database for Systematic Reviews using a search strategy to identify cross-sectional studies reporting on the prevalence of MSD in HHs or cleaners. The risk of bias was assessed with Joanna Briggs Institute tool for systematic reviews. A random-effects model was used in the meta-analysis. RESULTS: Nineteen studies were included in the systematic review, nine of them in the meta-analysis (n = 2299). The study sample sizes ranged from 24 to 1043 participants. The Standardized Nordic Musculoskeletal Questionnaire was the most common tool used to assess MSD among both HHs and cleaners (9/19 of the included studies). The three most affected anatomic locations were the low back 53.9% (95% CI: 43.3-64.6), shoulders 41.4% (95% CI: 27.1-55.8), and wrists/hands 40.1% (95% CI: 24.5-55.7). CONCLUSIONS: HHs and cleaners have a high prevalence of MSD. Low back pain is the most prevalent MSD among both HHs and cleaners affecting up to one of two people.},
  address = {Netherlands},
  author = {Sánchez-Rodríguez, Cristian and Capitán-Moyano, Laura and Malih, Narges and Yáñez, Aina M and Bennasar-Veny, Miquel and Velasco-Roldán, Olga and Bulilete, Oana and Llobera-Canaves, Joan},
  journal = {Musculoskeletal science & practice},
  keywords = {evisap},
  month = {feb},
  pages = {102890--102890},
  title = {Prevalence of musculoskeletal disorders among hotel housekeepers and cleaners: A systematic review with meta-analysis},
  volume = 69,
  year = 2024
  }
  

  %0 Journal Article
  %1 sanchezrodriguez2024prevalence
  %A Sánchez-Rodríguez, Cristian
  %A Capitán-Moyano, Laura
  %A Malih, Narges
  %A Yáñez, Aina M
  %A Bennasar-Veny, Miquel
  %A Velasco-Roldán, Olga
  %A Bulilete, Oana
  %A Llobera-Canaves, Joan
  %C Netherlands
  %D 2024
  %J Musculoskeletal science & practice
  %P 102890--102890
  %R 10.1016/j.msksp.2023.102890
  %T Prevalence of musculoskeletal disorders among hotel housekeepers and cleaners: A systematic review with meta-analysis
  %U https://pubmed.ncbi.nlm.nih.gov/38081106
  %V 69
  %X BACKGROUND: Musculoskeletal disorders (MSD) are among the most frequent and costly occupational health problems with a rising prevalence globally. OBJECTIVE: This systematic review with meta-analysis was conducted to know and evaluate the prevalence of MSD by anatomic location among hotel housekeepers (HHs) and cleaners. METHODS: Electronic searches were conducted in PubMed, Web of Science, Scopus, Dialnet Plus, PEDro and Cochrane Database for Systematic Reviews using a search strategy to identify cross-sectional studies reporting on the prevalence of MSD in HHs or cleaners. The risk of bias was assessed with Joanna Briggs Institute tool for systematic reviews. A random-effects model was used in the meta-analysis. RESULTS: Nineteen studies were included in the systematic review, nine of them in the meta-analysis (n = 2299). The study sample sizes ranged from 24 to 1043 participants. The Standardized Nordic Musculoskeletal Questionnaire was the most common tool used to assess MSD among both HHs and cleaners (9/19 of the included studies). The three most affected anatomic locations were the low back 53.9% (95% CI: 43.3-64.6), shoulders 41.4% (95% CI: 27.1-55.8), and wrists/hands 40.1% (95% CI: 24.5-55.7). CONCLUSIONS: HHs and cleaners have a high prevalence of MSD. Low back pain is the most prevalent MSD among both HHs and cleaners affecting up to one of two people.
  

• 
  1.

  Fiol deRoque MA, Mansilla GV, Maderuelo-Fernández JA, Tamayo-Morales O, Martín-Luján F, Astier-Peña P, Chacón-Docampo M, Orrego C, Gens-Barberà M, Andreu-Rodrigo P, Ricci-Cabello I, team S. Evaluation of SINERGIAPS, an intervention to improve patient safety in primary healthcare centers in Spain based on patients’ perceptions and experiences: a protocol for a hybrid type I randomized clinical trial. Frontiers in public health [Internet]. Switzerland; 2024 Mar.;12:1324940-. https://pubmed.ncbi.nlm.nih.gov/38596515

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Adverse events in the primary care setting result in a direct cost equivalent to at least 2.5% of total healthcare spending. Across OECD countries, they lead to more than seven million avoidable hospital admissions annually. In this manuscript, we describe the protocol of a trial aimed at evaluating the effectiveness of SinergiAPS (a patient-centered audit and feedback intervention) in reducing avoidable hospital admission and explore the factors that may affect its implementation. METHODS: We will conduct a 24-month, parallel, open-label, multicenter, pragmatic, hybrid type 1 randomized clinical trial. 118 primary healthcare centers with wide geographical distribution in Spain will be randomly assigned (ratio 1:1) to two groups. The intervention group will receive two audits (baseline and intermediate at 12 months) based on information collected through the administration of the PREOS-PC questionnaire (a measure of patient-reported patient safety) to a convenience sample of 100 patients per center. The intervention group will receive reports on the results of both audits, along with educational resources aimed at facilitating the design and implementation of safety improvement plans. The control group will receive care as usual. The primary outcome will be the rate of avoidable hospitalizations (administrative data). Secondary outcomes: patient-reported patient safety experiences and outcomes (PREOS-PC questionnaire); patient safety culture as perceived by professionals (MOSPSC questionnaire); adverse events reported by healthcare professionals (ad hoc questionnaire); the number of safety improvement actions which the re has implemented (ad hoc questionnaire). Outcome data will be collected at baseline and 24 months follow-up. For the evaluation of the implementation of the SinergiAPS intervention, we will draw on the Consolidated Framework for Implementation Research (CFIR). We will collect and analyze qualitative and quantitative data (30 individual interviews, implementation logbooks; questionnaires for professionals from intervention centers, and level of use of the SinergiAPS web tool). DISCUSSION: This study will expand the scarce body of evidence existing regarding the effects and implementation of interventions aimed at promoting patient and family engagement in primary healthcare, specifically for enhancing patient safety. The study has the potential to produce an impact on clinical practice, healthcare systems, and population health.Clinical Trial Registration: https://clinicaltrials.gov/study/NCT05958108?term=sinergiAPS&rank=1 (NCT05958108).

  @article{fiolderoque2024evaluation,
  abstract = {BACKGROUND: Adverse events in the primary care setting result in a direct cost equivalent to at least 2.5% of total healthcare spending. Across OECD countries, they lead to more than seven million avoidable hospital admissions annually. In this manuscript, we describe the protocol of a trial aimed at evaluating the effectiveness of SinergiAPS (a patient-centered audit and feedback intervention) in reducing avoidable hospital admission and explore the factors that may affect its implementation. METHODS: We will conduct a 24-month, parallel, open-label, multicenter, pragmatic, hybrid type 1 randomized clinical trial. 118 primary healthcare centers with wide geographical distribution in Spain will be randomly assigned (ratio 1:1) to two groups. The intervention group will receive two audits (baseline and intermediate at 12 months) based on information collected through the administration of the PREOS-PC questionnaire (a measure of patient-reported patient safety) to a convenience sample of 100 patients per center. The intervention group will receive reports on the results of both audits, along with educational resources aimed at facilitating the design and implementation of safety improvement plans. The control group will receive care as usual. The primary outcome will be the rate of avoidable hospitalizations (administrative data). Secondary outcomes: patient-reported patient safety experiences and outcomes (PREOS-PC questionnaire); patient safety culture as perceived by professionals (MOSPSC questionnaire); adverse events reported by healthcare professionals (ad hoc questionnaire); the number of safety improvement actions which the re has implemented (ad hoc questionnaire). Outcome data will be collected at baseline and 24 months follow-up. For the evaluation of the implementation of the SinergiAPS intervention, we will draw on the Consolidated Framework for Implementation Research (CFIR). We will collect and analyze qualitative and quantitative data (30 individual interviews, implementation logbooks; questionnaires for professionals from intervention centers, and level of use of the SinergiAPS web tool). DISCUSSION: This study will expand the scarce body of evidence existing regarding the effects and implementation of interventions aimed at promoting patient and family engagement in primary healthcare, specifically for enhancing patient safety. The study has the potential to produce an impact on clinical practice, healthcare systems, and population health.Clinical Trial Registration: https://clinicaltrials.gov/study/NCT05958108?term=sinergiAPS&rank=1 (NCT05958108).},
  address = {Switzerland},
  author = {Fiol deRoque, Maria A and Mansilla, Georgina Vidal and Maderuelo-Fernández, José A and Tamayo-Morales, Olaya and Martín-Luján, Francisco and Astier-Peña, Pilar and Chacón-Docampo, Macarena and Orrego, Carola and Gens-Barberà, Montserrat and Andreu-Rodrigo, Pilar and Ricci-Cabello, Ignacio and team, SinergiAPS},
  journal = {Frontiers in public health},
  keywords = {evisap myown},
  month = {mar},
  pages = {1324940--1324940},
  title = {Evaluation of SINERGIAPS, an intervention to improve patient safety in primary healthcare centers in Spain based on patients' perceptions and experiences: a protocol for a hybrid type I randomized clinical trial},
  volume = 12,
  year = 2024
  }
  

  %0 Journal Article
  %1 fiolderoque2024evaluation
  %A Fiol deRoque, Maria A
  %A Mansilla, Georgina Vidal
  %A Maderuelo-Fernández, José A
  %A Tamayo-Morales, Olaya
  %A Martín-Luján, Francisco
  %A Astier-Peña, Pilar
  %A Chacón-Docampo, Macarena
  %A Orrego, Carola
  %A Gens-Barberà, Montserrat
  %A Andreu-Rodrigo, Pilar
  %A Ricci-Cabello, Ignacio
  %A team, SinergiAPS
  %C Switzerland
  %D 2024
  %J Frontiers in public health
  %P 1324940--1324940
  %R 10.3389/fpubh.2024.1324940
  %T Evaluation of SINERGIAPS, an intervention to improve patient safety in primary healthcare centers in Spain based on patients' perceptions and experiences: a protocol for a hybrid type I randomized clinical trial
  %U https://pubmed.ncbi.nlm.nih.gov/38596515
  %V 12
  %X BACKGROUND: Adverse events in the primary care setting result in a direct cost equivalent to at least 2.5% of total healthcare spending. Across OECD countries, they lead to more than seven million avoidable hospital admissions annually. In this manuscript, we describe the protocol of a trial aimed at evaluating the effectiveness of SinergiAPS (a patient-centered audit and feedback intervention) in reducing avoidable hospital admission and explore the factors that may affect its implementation. METHODS: We will conduct a 24-month, parallel, open-label, multicenter, pragmatic, hybrid type 1 randomized clinical trial. 118 primary healthcare centers with wide geographical distribution in Spain will be randomly assigned (ratio 1:1) to two groups. The intervention group will receive two audits (baseline and intermediate at 12 months) based on information collected through the administration of the PREOS-PC questionnaire (a measure of patient-reported patient safety) to a convenience sample of 100 patients per center. The intervention group will receive reports on the results of both audits, along with educational resources aimed at facilitating the design and implementation of safety improvement plans. The control group will receive care as usual. The primary outcome will be the rate of avoidable hospitalizations (administrative data). Secondary outcomes: patient-reported patient safety experiences and outcomes (PREOS-PC questionnaire); patient safety culture as perceived by professionals (MOSPSC questionnaire); adverse events reported by healthcare professionals (ad hoc questionnaire); the number of safety improvement actions which the re has implemented (ad hoc questionnaire). Outcome data will be collected at baseline and 24 months follow-up. For the evaluation of the implementation of the SinergiAPS intervention, we will draw on the Consolidated Framework for Implementation Research (CFIR). We will collect and analyze qualitative and quantitative data (30 individual interviews, implementation logbooks; questionnaires for professionals from intervention centers, and level of use of the SinergiAPS web tool). DISCUSSION: This study will expand the scarce body of evidence existing regarding the effects and implementation of interventions aimed at promoting patient and family engagement in primary healthcare, specifically for enhancing patient safety. The study has the potential to produce an impact on clinical practice, healthcare systems, and population health.Clinical Trial Registration: https://clinicaltrials.gov/study/NCT05958108?term=sinergiAPS&rank=1 (NCT05958108).
  

• 
  1.

  Sastre-Alzamora T, Tárraga López PJ, López-González Ángel A, Vallejos D, Paublini H, Ramírez Manent JI. Usefulness of Atherogenic Indices for Predicting High Values of Avoidable Lost Life Years Heart Age in 139,634 Spanish Workers. Diagnostics (Basel, Switzerland) [Internet]. Switzerland; 2024 Oct.;14(21):2388-. https://pubmed.ncbi.nlm.nih.gov/39518356

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, accounting for one-third of all global deaths. The World Health Organization (WHO) asserts that prevention is the most effective strategy to combat CVD, emphasizing the need for non-invasive, low-cost tools to identify individuals at high risk of CVD. Atherogenic indices and heart age (HA) are valuable tools for assessing cardiovascular risk (CVR). The aim of our study was to evaluate the association between atherogenic indices and HA. METHODS: A cross-sectional study was conducted involving 139,634 Spanish workers to determine the association between three atherogenic indices and HA. ROC curves were employed to identify the cut-off values for the various atherogenic indices used to estimate high HA. The cut-off points, along with their sensitivity, specificity, and Youden index, were determined, and the area under the curve (AUC) was calculated. RESULTS: As the values of the atherogenic indices increased, so did the risk of having elevated avoidable lost life years (ALLY) HA. In the ROC curve analysis, the AUC with the best results corresponded to the total cholesterol/HDL-c atherogenic index, with an AUC of 0.803 in females and 0.790 in males. The LDL-c/HDL-c atherogenic index showed an AUC of 0.780 in women and 0.750 in men, with Youden indices around 0.4. When analyzing the AUC of the atherogenic index for triglycerides/HDL-c, the results were 0.760 in women and 0.746 in men. CONCLUSIONS: Atherogenic indices and HA show a close relationship, with an increase in these indices leading to a rise in HA values. Raising patient awareness that as their CVR levels increase, so does their HA may be useful in achieving some benefit in reducing CVR.

  @article{sastrealzamora2024usefulness,
  abstract = {BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, accounting for one-third of all global deaths. The World Health Organization (WHO) asserts that prevention is the most effective strategy to combat CVD, emphasizing the need for non-invasive, low-cost tools to identify individuals at high risk of CVD. Atherogenic indices and heart age (HA) are valuable tools for assessing cardiovascular risk (CVR). The aim of our study was to evaluate the association between atherogenic indices and HA. METHODS: A cross-sectional study was conducted involving 139,634 Spanish workers to determine the association between three atherogenic indices and HA. ROC curves were employed to identify the cut-off values for the various atherogenic indices used to estimate high HA. The cut-off points, along with their sensitivity, specificity, and Youden index, were determined, and the area under the curve (AUC) was calculated. RESULTS: As the values of the atherogenic indices increased, so did the risk of having elevated avoidable lost life years (ALLY) HA. In the ROC curve analysis, the AUC with the best results corresponded to the total cholesterol/HDL-c atherogenic index, with an AUC of 0.803 in females and 0.790 in males. The LDL-c/HDL-c atherogenic index showed an AUC of 0.780 in women and 0.750 in men, with Youden indices around 0.4. When analyzing the AUC of the atherogenic index for triglycerides/HDL-c, the results were 0.760 in women and 0.746 in men. CONCLUSIONS: Atherogenic indices and HA show a close relationship, with an increase in these indices leading to a rise in HA values. Raising patient awareness that as their CVR levels increase, so does their HA may be useful in achieving some benefit in reducing CVR.},
  address = {Switzerland},
  author = {Sastre-Alzamora, Tomás and Tárraga López, Pedro J and López-González, Ángel Arturo and Vallejos, Daniela and Paublini, Hernán and Ramírez Manent, José Ignacio},
  journal = {Diagnostics (Basel, Switzerland)},
  keywords = {grapp-caib},
  month = {oct},
  number = 21,
  pages = {2388--},
  title = {Usefulness of Atherogenic Indices for Predicting High Values of Avoidable Lost Life Years Heart Age in 139,634 Spanish Workers},
  volume = 14,
  year = 2024
  }
  

  %0 Journal Article
  %1 sastrealzamora2024usefulness
  %A Sastre-Alzamora, Tomás
  %A Tárraga López, Pedro J
  %A López-González, Ángel Arturo
  %A Vallejos, Daniela
  %A Paublini, Hernán
  %A Ramírez Manent, José Ignacio
  %C Switzerland
  %D 2024
  %J Diagnostics (Basel, Switzerland)
  %N 21
  %P 2388--
  %R 10.3390/diagnostics14212388
  %T Usefulness of Atherogenic Indices for Predicting High Values of Avoidable Lost Life Years Heart Age in 139,634 Spanish Workers
  %U https://pubmed.ncbi.nlm.nih.gov/39518356
  %V 14
  %X BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, accounting for one-third of all global deaths. The World Health Organization (WHO) asserts that prevention is the most effective strategy to combat CVD, emphasizing the need for non-invasive, low-cost tools to identify individuals at high risk of CVD. Atherogenic indices and heart age (HA) are valuable tools for assessing cardiovascular risk (CVR). The aim of our study was to evaluate the association between atherogenic indices and HA. METHODS: A cross-sectional study was conducted involving 139,634 Spanish workers to determine the association between three atherogenic indices and HA. ROC curves were employed to identify the cut-off values for the various atherogenic indices used to estimate high HA. The cut-off points, along with their sensitivity, specificity, and Youden index, were determined, and the area under the curve (AUC) was calculated. RESULTS: As the values of the atherogenic indices increased, so did the risk of having elevated avoidable lost life years (ALLY) HA. In the ROC curve analysis, the AUC with the best results corresponded to the total cholesterol/HDL-c atherogenic index, with an AUC of 0.803 in females and 0.790 in males. The LDL-c/HDL-c atherogenic index showed an AUC of 0.780 in women and 0.750 in men, with Youden indices around 0.4. When analyzing the AUC of the atherogenic index for triglycerides/HDL-c, the results were 0.760 in women and 0.746 in men. CONCLUSIONS: Atherogenic indices and HA show a close relationship, with an increase in these indices leading to a rise in HA values. Raising patient awareness that as their CVR levels increase, so does their HA may be useful in achieving some benefit in reducing CVR.
  

• 
  1.

  Navarra-Ventura G, Riera-Serra P, Roca M, Gili M, García-Toro M, Vilagut G, Alayo I, Ballester L, Blasco MJ, Castellví P, Colom J, Casajuana C, Gabilondo A, Lagares C, Almenara J, Miranda-Mendizabal A, Mortier P, Piqueras JA, Soto-Sanz V, Alonso J, study group U. Factors associated with high and low mental well-being in Spanish university students. Journal of affective disorders [Internet]. Netherlands; 2024 Jul.;356:424-35. https://pubmed.ncbi.nlm.nih.gov/38631424

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Previous studies conducted in various nationally representative samples of the general population show that positive mental health is related to social prosperity. However, specific studies in university populations are scarce. In this study, we set out to explore factors associated with mental well-being (MWB) in a representative sample of first-year university students in Spain. METHODS: MWB was assessed with the short version of the Warwick-Edinburgh Mental Well-Being Scale. Multinomial logistic regressions were performed to explore the association between different blocks of factors, including relational, adversity, stress, lifestyle, spiritual, health, and self-perceived health variables with high and low MWB, controlling for sociodemographic and university-related variables. RESULTS: Data from 2082 students (18.6 ± 1.2 years; 56.6 % females) were analysed. Being male, being born in a foreign country, "high" self-perceived support, and "high" self-perceived mental health increased the odds of high MWB. Growing up in the suburbs, stressful experiences, and anxiety disorders reduced the odds of high MWB. Mood and anxiety disorders increased the odds of low MWB. "Middle" self-perceived support, sleeping ≥8 h per day, and "high" self-perceived mental health reduced the odds of low MWB. LIMITATIONS: The cross-sectional design precludes establishing causal relationships. Data were collected in the 2014-15 academic year using self-reported online surveys. CONCLUSION: The factors associated with high and low MWB do not always mirror each other, so specific plans are needed to successfully address each of the two poles. Interventions and policies targeting these factors for health promotion and disease prevention would improve the MWB of university students.

  @article{navarraventura2024factors,
  abstract = {BACKGROUND: Previous studies conducted in various nationally representative samples of the general population show that positive mental health is related to social prosperity. However, specific studies in university populations are scarce. In this study, we set out to explore factors associated with mental well-being (MWB) in a representative sample of first-year university students in Spain. METHODS: MWB was assessed with the short version of the Warwick-Edinburgh Mental Well-Being Scale. Multinomial logistic regressions were performed to explore the association between different blocks of factors, including relational, adversity, stress, lifestyle, spiritual, health, and self-perceived health variables with high and low MWB, controlling for sociodemographic and university-related variables. RESULTS: Data from 2082 students (18.6 ± 1.2 years; 56.6 % females) were analysed. Being male, being born in a foreign country, "high" self-perceived support, and "high" self-perceived mental health increased the odds of high MWB. Growing up in the suburbs, stressful experiences, and anxiety disorders reduced the odds of high MWB. Mood and anxiety disorders increased the odds of low MWB. "Middle" self-perceived support, sleeping ≥8 h per day, and "high" self-perceived mental health reduced the odds of low MWB. LIMITATIONS: The cross-sectional design precludes establishing causal relationships. Data were collected in the 2014-15 academic year using self-reported online surveys. CONCLUSION: The factors associated with high and low MWB do not always mirror each other, so specific plans are needed to successfully address each of the two poles. Interventions and policies targeting these factors for health promotion and disease prevention would improve the MWB of university students.},
  address = {Netherlands},
  author = {Navarra-Ventura, Guillem and Riera-Serra, Pau and Roca, Miquel and Gili, Margalida and García-Toro, Mauro and Vilagut, Gemma and Alayo, Itxaso and Ballester, Laura and Blasco, Maria Jesús and Castellví, Pere and Colom, Joan and Casajuana, Cristina and Gabilondo, Andrea and Lagares, Carolina and Almenara, José and Miranda-Mendizabal, Andrea and Mortier, Philippe and Piqueras, José Antonio and Soto-Sanz, Victoria and Alonso, Jordi and study group, UNIVERSAL},
  journal = {Journal of affective disorders},
  keywords = {evisap},
  month = {jul},
  pages = {424--435},
  title = {Factors associated with high and low mental well-being in Spanish university students},
  volume = 356,
  year = 2024
  }
  

  %0 Journal Article
  %1 navarraventura2024factors
  %A Navarra-Ventura, Guillem
  %A Riera-Serra, Pau
  %A Roca, Miquel
  %A Gili, Margalida
  %A García-Toro, Mauro
  %A Vilagut, Gemma
  %A Alayo, Itxaso
  %A Ballester, Laura
  %A Blasco, Maria Jesús
  %A Castellví, Pere
  %A Colom, Joan
  %A Casajuana, Cristina
  %A Gabilondo, Andrea
  %A Lagares, Carolina
  %A Almenara, José
  %A Miranda-Mendizabal, Andrea
  %A Mortier, Philippe
  %A Piqueras, José Antonio
  %A Soto-Sanz, Victoria
  %A Alonso, Jordi
  %A study group, UNIVERSAL
  %C Netherlands
  %D 2024
  %J Journal of affective disorders
  %P 424--435
  %R 10.1016/j.jad.2024.04.056
  %T Factors associated with high and low mental well-being in Spanish university students
  %U https://pubmed.ncbi.nlm.nih.gov/38631424
  %V 356
  %X BACKGROUND: Previous studies conducted in various nationally representative samples of the general population show that positive mental health is related to social prosperity. However, specific studies in university populations are scarce. In this study, we set out to explore factors associated with mental well-being (MWB) in a representative sample of first-year university students in Spain. METHODS: MWB was assessed with the short version of the Warwick-Edinburgh Mental Well-Being Scale. Multinomial logistic regressions were performed to explore the association between different blocks of factors, including relational, adversity, stress, lifestyle, spiritual, health, and self-perceived health variables with high and low MWB, controlling for sociodemographic and university-related variables. RESULTS: Data from 2082 students (18.6 ± 1.2 years; 56.6 % females) were analysed. Being male, being born in a foreign country, "high" self-perceived support, and "high" self-perceived mental health increased the odds of high MWB. Growing up in the suburbs, stressful experiences, and anxiety disorders reduced the odds of high MWB. Mood and anxiety disorders increased the odds of low MWB. "Middle" self-perceived support, sleeping ≥8 h per day, and "high" self-perceived mental health reduced the odds of low MWB. LIMITATIONS: The cross-sectional design precludes establishing causal relationships. Data were collected in the 2014-15 academic year using self-reported online surveys. CONCLUSION: The factors associated with high and low MWB do not always mirror each other, so specific plans are needed to successfully address each of the two poles. Interventions and policies targeting these factors for health promotion and disease prevention would improve the MWB of university students.
  

• 
  1.

  Ramírez-Gallegos I, Marina-Arroyo M, López-González Ángel A, Vallejos D, Martínez-Almoyna-Rifá E, Tárraga López PJ, Ramírez-Manent JI. Associations Between Metabolic Age, Sociodemographic Variables, and Lifestyle Factors in Spanish Workers. Nutrients [Internet]. Switzerland; 2024 Dec.;16(23):4207-. https://pubmed.ncbi.nlm.nih.gov/39683600

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Metabolic age is defined as an estimation of a person's age based on their basal metabolic rate (BMR) and other physiological health indicators. Unlike chronological age, which simply measures the number of years lived since birth, metabolic age is based on various health and fitness markers that estimate the body's "true" biological age and can be assessed using various methodologies, including bioimpedance. The aim of this study was to evaluate how age, sex, social class, smoking habits, physical activity, and adherence to the Mediterranean diet influence metabolic age. METHODS: A cross-sectional, descriptive study was conducted on 8590 Spanish workers in the Balearic Islands. A series of sociodemographic variables and health-related habits were assessed, while metabolic age was measured using bioimpedance. A metabolic age exceeding chronological age by 12 years or more was considered high. A descriptive analysis of categorical variables was performed by calculating their frequency and distribution. By applying multivariate models, specifically multinomial logistic regression, we observe that all independent variables (sex, age, social class, physical activity, mediterranean diet, and smoking) show varying levels of association with the occurrence of high metabolic age values. Among these independent variables, those showing the highest degree of association, represented by odds ratios, are physical activity, adherence to the Mediterranean diet, and social class. In all cases, the observed differences demonstrate a high level of statistical significance (p < 0.001). RESULTS: The factors with the greatest influence were physical inactivity, with an OR of 5.07; and low adherence to the Mediterranean diet, with an OR of 2.8; followed by social class, with an OR of 2.51. Metabolic age increased with chronological age and was higher in males, with an OR of 1.38. Smoking also had a negative impact on metabolic age, with an OR of 1.19. CONCLUSIONS: Mediterranean diet is associated with a higher metabolic age. The most influential factors on metabolic age are physical activity and adherence to the Mediterranean diet, followed by the individual's socioeconomic class. Smoking also contributes to increased metabolic age, albeit to a lesser extent.

  @article{ramirezgallegos2024associations,
  abstract = {BACKGROUND: Metabolic age is defined as an estimation of a person's age based on their basal metabolic rate (BMR) and other physiological health indicators. Unlike chronological age, which simply measures the number of years lived since birth, metabolic age is based on various health and fitness markers that estimate the body's "true" biological age and can be assessed using various methodologies, including bioimpedance. The aim of this study was to evaluate how age, sex, social class, smoking habits, physical activity, and adherence to the Mediterranean diet influence metabolic age. METHODS: A cross-sectional, descriptive study was conducted on 8590 Spanish workers in the Balearic Islands. A series of sociodemographic variables and health-related habits were assessed, while metabolic age was measured using bioimpedance. A metabolic age exceeding chronological age by 12 years or more was considered high. A descriptive analysis of categorical variables was performed by calculating their frequency and distribution. By applying multivariate models, specifically multinomial logistic regression, we observe that all independent variables (sex, age, social class, physical activity, mediterranean diet, and smoking) show varying levels of association with the occurrence of high metabolic age values. Among these independent variables, those showing the highest degree of association, represented by odds ratios, are physical activity, adherence to the Mediterranean diet, and social class. In all cases, the observed differences demonstrate a high level of statistical significance (p < 0.001). RESULTS: The factors with the greatest influence were physical inactivity, with an OR of 5.07; and low adherence to the Mediterranean diet, with an OR of 2.8; followed by social class, with an OR of 2.51. Metabolic age increased with chronological age and was higher in males, with an OR of 1.38. Smoking also had a negative impact on metabolic age, with an OR of 1.19. CONCLUSIONS: Mediterranean diet is associated with a higher metabolic age. The most influential factors on metabolic age are physical activity and adherence to the Mediterranean diet, followed by the individual's socioeconomic class. Smoking also contributes to increased metabolic age, albeit to a lesser extent.},
  address = {Switzerland},
  author = {Ramírez-Gallegos, Ignacio and Marina-Arroyo, Marta and López-González, Ángel Arturo and Vallejos, Daniela and Martínez-Almoyna-Rifá, Emilio and Tárraga López, Pedro Juan and Ramírez-Manent, José Ignacio},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {dec},
  number = 23,
  pages = {4207--},
  title = {Associations Between Metabolic Age, Sociodemographic Variables, and Lifestyle Factors in Spanish Workers},
  volume = 16,
  year = 2024
  }
  

  %0 Journal Article
  %1 ramirezgallegos2024associations
  %A Ramírez-Gallegos, Ignacio
  %A Marina-Arroyo, Marta
  %A López-González, Ángel Arturo
  %A Vallejos, Daniela
  %A Martínez-Almoyna-Rifá, Emilio
  %A Tárraga López, Pedro Juan
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2024
  %J Nutrients
  %N 23
  %P 4207--
  %R 10.3390/nu16234207
  %T Associations Between Metabolic Age, Sociodemographic Variables, and Lifestyle Factors in Spanish Workers
  %U https://pubmed.ncbi.nlm.nih.gov/39683600
  %V 16
  %X BACKGROUND: Metabolic age is defined as an estimation of a person's age based on their basal metabolic rate (BMR) and other physiological health indicators. Unlike chronological age, which simply measures the number of years lived since birth, metabolic age is based on various health and fitness markers that estimate the body's "true" biological age and can be assessed using various methodologies, including bioimpedance. The aim of this study was to evaluate how age, sex, social class, smoking habits, physical activity, and adherence to the Mediterranean diet influence metabolic age. METHODS: A cross-sectional, descriptive study was conducted on 8590 Spanish workers in the Balearic Islands. A series of sociodemographic variables and health-related habits were assessed, while metabolic age was measured using bioimpedance. A metabolic age exceeding chronological age by 12 years or more was considered high. A descriptive analysis of categorical variables was performed by calculating their frequency and distribution. By applying multivariate models, specifically multinomial logistic regression, we observe that all independent variables (sex, age, social class, physical activity, mediterranean diet, and smoking) show varying levels of association with the occurrence of high metabolic age values. Among these independent variables, those showing the highest degree of association, represented by odds ratios, are physical activity, adherence to the Mediterranean diet, and social class. In all cases, the observed differences demonstrate a high level of statistical significance (p < 0.001). RESULTS: The factors with the greatest influence were physical inactivity, with an OR of 5.07; and low adherence to the Mediterranean diet, with an OR of 2.8; followed by social class, with an OR of 2.51. Metabolic age increased with chronological age and was higher in males, with an OR of 1.38. Smoking also had a negative impact on metabolic age, with an OR of 1.19. CONCLUSIONS: Mediterranean diet is associated with a higher metabolic age. The most influential factors on metabolic age are physical activity and adherence to the Mediterranean diet, followed by the individual's socioeconomic class. Smoking also contributes to increased metabolic age, albeit to a lesser extent.
  

• 
  1.

  Pou Bordoy J, Leiva A, Albendín Ariza MJ, Llanos RE, Rigo Carratalà F, Romaguera D, Salas-Salvadó J, Babio N, Martinez-González MA, Toledo E, Fitó M, Aros F, Estruch R, Fiol Sala M. Major abnormalities of the electrocardiogram and cardiovascular risk in a medium and high-risk Mediterranean population. Medicina clinica [Internet]. Spain; 2024 Dec.;:S0025-7753(24)00665. https://pubmed.ncbi.nlm.nih.gov/39706740

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: Major electrocardiogram abnormalities (MECG) are common in middle-aged and older individuals and could be an important factor in predicting cardiovascular events. OBJECTIVE: To analyse the association between MECG (Minnesota classification) and CVE independently of classic cardiovascular risk factors (CVRF), and to assess whether they improve the prediction according to the Spanish Coronary Event Risk Function (FRESCO). METHOD: 1.752 participants included in three nodes of the PREDIMED study aged between 55 and 80 years with medium or high CVRF. Mean follow-up time was 5.1 years. Cumulative CVE incidence was estimated by sex with and without MECG, and hazard ratios by sex were estimated using multivariate Cox regressions adjusted for randomization group and CCRF (FRESCO). Harrel's C Indices, Nam d'Agostino, Net Reclassification Improvement, and Integrated Discrimination Improvement were calculated. RESULTS: At baseline, 25% of the participants shows major electrocardiogram abnormalities (AMECG). During follow-up, there were 112 cardiovascular events (16 cardiovascular deaths, 15 acute myocardial infarctions, 38 anginas, 43 strokes). MECG were significantly associated with the onset of CVE. In men, left ventricular hypertrophy (LVH) criteria were associated with T-wave inversion (HR: 17.88, 95% CI: 5.51-58.03, pvalor<.001) and QT interval prolongation (HR: 2.41, 95% CI: 1.38-4.21, pvalor=.002); in women, atrial fibrillation (HR: 5.7, 95% CI: 1.76-18.72, pvalor=.006) and ST-segment depression (HR: 3.24, 95% CI: 1.36-7.71, pvalor<.001) were associated. No significant improvement in MECG prediction compared to FRESCO was observed. CONCLUSIONS: MECG are independently associated with the occurrence of CVE, but do not improve risk prediction beyond traditional risk factors.

  @article{poubordoy2024major,
  abstract = {INTRODUCTION: Major electrocardiogram abnormalities (MECG) are common in middle-aged and older individuals and could be an important factor in predicting cardiovascular events. OBJECTIVE: To analyse the association between MECG (Minnesota classification) and CVE independently of classic cardiovascular risk factors (CVRF), and to assess whether they improve the prediction according to the Spanish Coronary Event Risk Function (FRESCO). METHOD: 1.752 participants included in three nodes of the PREDIMED study aged between 55 and 80 years with medium or high CVRF. Mean follow-up time was 5.1 years. Cumulative CVE incidence was estimated by sex with and without MECG, and hazard ratios by sex were estimated using multivariate Cox regressions adjusted for randomization group and CCRF (FRESCO). Harrel's C Indices, Nam d'Agostino, Net Reclassification Improvement, and Integrated Discrimination Improvement were calculated. RESULTS: At baseline, 25% of the participants shows major electrocardiogram abnormalities (AMECG). During follow-up, there were 112 cardiovascular events (16 cardiovascular deaths, 15 acute myocardial infarctions, 38 anginas, 43 strokes). MECG were significantly associated with the onset of CVE. In men, left ventricular hypertrophy (LVH) criteria were associated with T-wave inversion (HR: 17.88, 95% CI: 5.51-58.03, pvalor<.001) and QT interval prolongation (HR: 2.41, 95% CI: 1.38-4.21, pvalor=.002); in women, atrial fibrillation (HR: 5.7, 95% CI: 1.76-18.72, pvalor=.006) and ST-segment depression (HR: 3.24, 95% CI: 1.36-7.71, pvalor<.001) were associated. No significant improvement in MECG prediction compared to FRESCO was observed. CONCLUSIONS: MECG are independently associated with the occurrence of CVE, but do not improve risk prediction beyond traditional risk factors.},
  address = {Spain},
  author = {Pou Bordoy, Joan and Leiva, Alfonso and Albendín Ariza, Maria José and Llanos, Roberto Elosúa and Rigo Carratalà, Fernando and Romaguera, Dora and Salas-Salvadó, Jordi and Babio, Nancy and Martinez-González, Miguel Angel and Toledo, Estefanía and Fitó, Montserrat and Aros, Fernando and Estruch, Ramon and Fiol Sala, Miquel},
  journal = {Medicina clinica},
  keywords = {grapp-caib},
  month = {dec},
  pages = {S0025-7753(24)00665-1--},
  title = {Major abnormalities of the electrocardiogram and cardiovascular risk in a medium and high-risk Mediterranean population},
  year = 2024
  }
  

  %0 Journal Article
  %1 poubordoy2024major
  %A Pou Bordoy, Joan
  %A Leiva, Alfonso
  %A Albendín Ariza, Maria José
  %A Llanos, Roberto Elosúa
  %A Rigo Carratalà, Fernando
  %A Romaguera, Dora
  %A Salas-Salvadó, Jordi
  %A Babio, Nancy
  %A Martinez-González, Miguel Angel
  %A Toledo, Estefanía
  %A Fitó, Montserrat
  %A Aros, Fernando
  %A Estruch, Ramon
  %A Fiol Sala, Miquel
  %C Spain
  %D 2024
  %J Medicina clinica
  %P S0025-7753(24)00665-1--
  %R 10.1016/j.medcli.2024.10.010
  %T Major abnormalities of the electrocardiogram and cardiovascular risk in a medium and high-risk Mediterranean population
  %U https://pubmed.ncbi.nlm.nih.gov/39706740
  %X INTRODUCTION: Major electrocardiogram abnormalities (MECG) are common in middle-aged and older individuals and could be an important factor in predicting cardiovascular events. OBJECTIVE: To analyse the association between MECG (Minnesota classification) and CVE independently of classic cardiovascular risk factors (CVRF), and to assess whether they improve the prediction according to the Spanish Coronary Event Risk Function (FRESCO). METHOD: 1.752 participants included in three nodes of the PREDIMED study aged between 55 and 80 years with medium or high CVRF. Mean follow-up time was 5.1 years. Cumulative CVE incidence was estimated by sex with and without MECG, and hazard ratios by sex were estimated using multivariate Cox regressions adjusted for randomization group and CCRF (FRESCO). Harrel's C Indices, Nam d'Agostino, Net Reclassification Improvement, and Integrated Discrimination Improvement were calculated. RESULTS: At baseline, 25% of the participants shows major electrocardiogram abnormalities (AMECG). During follow-up, there were 112 cardiovascular events (16 cardiovascular deaths, 15 acute myocardial infarctions, 38 anginas, 43 strokes). MECG were significantly associated with the onset of CVE. In men, left ventricular hypertrophy (LVH) criteria were associated with T-wave inversion (HR: 17.88, 95% CI: 5.51-58.03, pvalor<.001) and QT interval prolongation (HR: 2.41, 95% CI: 1.38-4.21, pvalor=.002); in women, atrial fibrillation (HR: 5.7, 95% CI: 1.76-18.72, pvalor=.006) and ST-segment depression (HR: 3.24, 95% CI: 1.36-7.71, pvalor<.001) were associated. No significant improvement in MECG prediction compared to FRESCO was observed. CONCLUSIONS: MECG are independently associated with the occurrence of CVE, but do not improve risk prediction beyond traditional risk factors.
  

• 
  1.

  Pranić SM, Estevão MD, Vasanthan LT, Pérez-Neri I, Pulumati A, de Lima Junior FAS, Malih N, Mishra V, Thompson J, Nnate D. Reporting of Participant Race and Ethnicity from COVID-19 Randomized Controlled Drug and Biologicals Trials: A Scoping Review. Epidemiologic reviews [Internet]. United States; 2024 Nov.;:mxae006-. https://pubmed.ncbi.nlm.nih.gov/39673248

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Racial and ethnic minorities have been disproportionally burdened by hospitalization and death due to COVID-19. Participation of individuals of diverse races and ethnicities in clinical trials according to study-level characteristics of randomized controlled trials (RCT) that test effectiveness of COVID-19 drugs could be insightful for future researchers. The objective of this scoping review was to describe frequency of race and ethnicity reported as demographic variables and specific reporting of race and ethnicity according to COVID-19 RCT characteristics. We conducted comprehensive searches in Pubmed, ProQuest, WHO Database, and Cochrane Central Register of Controlled Trials, and gray literature via preprint servers from 1/1/2020 to 5/4/2022. We included RCTs on emergency- or conditionally-approved COVID-19 drug interventions (remdesivir, baricitinib, and molnupiravir) with or without comparators. Self-reported race as American Indian/Pacific Islander, Asian, Black/African American, or White, ethnicity as Hispanic/Latinx, study design characteristics, and participant-relevant data were collected. A total of 17 RCTs with 17935 participants was included. Most (n=13, 76%) reported at least one race and ethnicity and were US-based, industry-funded RCTs. Asian, Black, Latinx, and White participants were mostly enrolled in RCTs that studied remdesivir. Native American and Hawaiian participants were mostly assessed for progression to high-flow oxygen/non-invasive ventilation. Time to recovery was assessed predominantly in Black and White participants, while hospitalization or death was mostly assessed in Asian, Latinx, and multi-race participants. Trialists should be aware of RCT-level factors and characteristics that may be associated with low participation of racial and ethnic minorities, which could inform evidence-based interventions to increase minority participation.

  @article{pranic2024reporting,
  abstract = {Racial and ethnic minorities have been disproportionally burdened by hospitalization and death due to COVID-19. Participation of individuals of diverse races and ethnicities in clinical trials according to study-level characteristics of randomized controlled trials (RCT) that test effectiveness of COVID-19 drugs could be insightful for future researchers. The objective of this scoping review was to describe frequency of race and ethnicity reported as demographic variables and specific reporting of race and ethnicity according to COVID-19 RCT characteristics. We conducted comprehensive searches in Pubmed, ProQuest, WHO Database, and Cochrane Central Register of Controlled Trials, and gray literature via preprint servers from 1/1/2020 to 5/4/2022. We included RCTs on emergency- or conditionally-approved COVID-19 drug interventions (remdesivir, baricitinib, and molnupiravir) with or without comparators. Self-reported race as American Indian/Pacific Islander, Asian, Black/African American, or White, ethnicity as Hispanic/Latinx, study design characteristics, and participant-relevant data were collected. A total of 17 RCTs with 17935 participants was included. Most (n=13, 76%) reported at least one race and ethnicity and were US-based, industry-funded RCTs. Asian, Black, Latinx, and White participants were mostly enrolled in RCTs that studied remdesivir. Native American and Hawaiian participants were mostly assessed for progression to high-flow oxygen/non-invasive ventilation. Time to recovery was assessed predominantly in Black and White participants, while hospitalization or death was mostly assessed in Asian, Latinx, and multi-race participants. Trialists should be aware of RCT-level factors and characteristics that may be associated with low participation of racial and ethnic minorities, which could inform evidence-based interventions to increase minority participation.},
  address = {United States},
  author = {Pranić, Shelly Melissa and Estevão, Maria Dulce and Vasanthan, Lenny T and Pérez-Neri, Iván and Pulumati, Anika and de Lima Junior, Fábio Antonio Serra and Malih, Narges and Mishra, Vinayak and Thompson, Jacqueline and Nnate, Daniel},
  journal = {Epidemiologic reviews},
  keywords = {evisap grapp-caib},
  month = {nov},
  pages = {mxae006--},
  title = {Reporting of Participant Race and Ethnicity from COVID-19 Randomized Controlled Drug and Biologicals Trials: A Scoping Review},
  year = 2024
  }
  

  %0 Journal Article
  %1 pranic2024reporting
  %A Pranić, Shelly Melissa
  %A Estevão, Maria Dulce
  %A Vasanthan, Lenny T
  %A Pérez-Neri, Iván
  %A Pulumati, Anika
  %A de Lima Junior, Fábio Antonio Serra
  %A Malih, Narges
  %A Mishra, Vinayak
  %A Thompson, Jacqueline
  %A Nnate, Daniel
  %C United States
  %D 2024
  %J Epidemiologic reviews
  %P mxae006--
  %R 10.1093/epirev/mxae006
  %T Reporting of Participant Race and Ethnicity from COVID-19 Randomized Controlled Drug and Biologicals Trials: A Scoping Review
  %U https://pubmed.ncbi.nlm.nih.gov/39673248
  %X Racial and ethnic minorities have been disproportionally burdened by hospitalization and death due to COVID-19. Participation of individuals of diverse races and ethnicities in clinical trials according to study-level characteristics of randomized controlled trials (RCT) that test effectiveness of COVID-19 drugs could be insightful for future researchers. The objective of this scoping review was to describe frequency of race and ethnicity reported as demographic variables and specific reporting of race and ethnicity according to COVID-19 RCT characteristics. We conducted comprehensive searches in Pubmed, ProQuest, WHO Database, and Cochrane Central Register of Controlled Trials, and gray literature via preprint servers from 1/1/2020 to 5/4/2022. We included RCTs on emergency- or conditionally-approved COVID-19 drug interventions (remdesivir, baricitinib, and molnupiravir) with or without comparators. Self-reported race as American Indian/Pacific Islander, Asian, Black/African American, or White, ethnicity as Hispanic/Latinx, study design characteristics, and participant-relevant data were collected. A total of 17 RCTs with 17935 participants was included. Most (n=13, 76%) reported at least one race and ethnicity and were US-based, industry-funded RCTs. Asian, Black, Latinx, and White participants were mostly enrolled in RCTs that studied remdesivir. Native American and Hawaiian participants were mostly assessed for progression to high-flow oxygen/non-invasive ventilation. Time to recovery was assessed predominantly in Black and White participants, while hospitalization or death was mostly assessed in Asian, Latinx, and multi-race participants. Trialists should be aware of RCT-level factors and characteristics that may be associated with low participation of racial and ethnic minorities, which could inform evidence-based interventions to increase minority participation.
  

• 
  1.

  Tosoratto J, Tárraga López PJ, López-González Ángel A, Vallejos D, Martínez-Almoyna Rifá E, Ramirez-Manent JI. Association of Shift Work, Sociodemographic Variables and Healthy Habits with Obesity Scales. Life (Basel, Switzerland) [Internet]. Switzerland; 2024 Nov.;14(11):1503-. https://pubmed.ncbi.nlm.nih.gov/39598301

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Shift work has been associated with unhealthy lifestyle habits and a higher prevalence of obesity, which negatively impacts the health of shift workers. The objective of our study was to examine the influence of shift work on obesity, as well as on sociodemographic variables, anthropometric measurements, and lifestyle habits in individuals working this type of schedule. METHODS: An observational, cross-sectional, descriptive study involving 53,053 workers from various labour sectors across several Spanish autonomous communities was conducted. It included 31,753 men (17,527 of them working shifts) and 21,300 women (11,281 of them working shifts). The relationship between shift work and obesity was examined, as well as its association with sex, age, social class, education level, smoking, alcohol consumption, sedentary behaviour, and unhealthy diet. RESULTS: Obesity showed higher prevalence and mean values among shift workers across all four formulas used (BMI obesity, WtHR high, CUN BAE obesity, METS-VF high). All variables related to unhealthy lifestyle habits revealed a significantly greater prevalence among shift workers, with high statistical significance (p < 0.001). Age, sex, and social class affected the risk of obesity, with a greater prevalence observed in shift workers compared to non-shift workers (p < 0.001). Men had a higher risk than women, with an OR ranging from 1.17 (1.12-1.21) for BMI obesity to 7.45 (6.71-8.20) for METS-VF high. CONCLUSIONS: Shift workers exhibit a higher prevalence of obesity and unhealthy lifestyle habits, with men at greater risk. The variables that most significantly increase the risk of obesity include age, physical inactivity, low adherence to the Mediterranean diet, and alcohol consumption.

  @article{tosoratto2024association,
  abstract = {BACKGROUND: Shift work has been associated with unhealthy lifestyle habits and a higher prevalence of obesity, which negatively impacts the health of shift workers. The objective of our study was to examine the influence of shift work on obesity, as well as on sociodemographic variables, anthropometric measurements, and lifestyle habits in individuals working this type of schedule. METHODS: An observational, cross-sectional, descriptive study involving 53,053 workers from various labour sectors across several Spanish autonomous communities was conducted. It included 31,753 men (17,527 of them working shifts) and 21,300 women (11,281 of them working shifts). The relationship between shift work and obesity was examined, as well as its association with sex, age, social class, education level, smoking, alcohol consumption, sedentary behaviour, and unhealthy diet. RESULTS: Obesity showed higher prevalence and mean values among shift workers across all four formulas used (BMI obesity, WtHR high, CUN BAE obesity, METS-VF high). All variables related to unhealthy lifestyle habits revealed a significantly greater prevalence among shift workers, with high statistical significance (p < 0.001). Age, sex, and social class affected the risk of obesity, with a greater prevalence observed in shift workers compared to non-shift workers (p < 0.001). Men had a higher risk than women, with an OR ranging from 1.17 (1.12-1.21) for BMI obesity to 7.45 (6.71-8.20) for METS-VF high. CONCLUSIONS: Shift workers exhibit a higher prevalence of obesity and unhealthy lifestyle habits, with men at greater risk. The variables that most significantly increase the risk of obesity include age, physical inactivity, low adherence to the Mediterranean diet, and alcohol consumption.},
  address = {Switzerland},
  author = {Tosoratto, Javier and Tárraga López, Pedro Juan and López-González, Ángel Arturo and Vallejos, Daniela and Martínez-Almoyna Rifá, Emilio and Ramirez-Manent, José Ignacio},
  journal = {Life (Basel, Switzerland)},
  keywords = {grapp-caib},
  month = {nov},
  number = 11,
  pages = {1503--},
  title = {Association of Shift Work, Sociodemographic Variables and Healthy Habits with Obesity Scales},
  volume = 14,
  year = 2024
  }
  

  %0 Journal Article
  %1 tosoratto2024association
  %A Tosoratto, Javier
  %A Tárraga López, Pedro Juan
  %A López-González, Ángel Arturo
  %A Vallejos, Daniela
  %A Martínez-Almoyna Rifá, Emilio
  %A Ramirez-Manent, José Ignacio
  %C Switzerland
  %D 2024
  %J Life (Basel, Switzerland)
  %N 11
  %P 1503--
  %R 10.3390/life14111503
  %T Association of Shift Work, Sociodemographic Variables and Healthy Habits with Obesity Scales
  %U https://pubmed.ncbi.nlm.nih.gov/39598301
  %V 14
  %X BACKGROUND: Shift work has been associated with unhealthy lifestyle habits and a higher prevalence of obesity, which negatively impacts the health of shift workers. The objective of our study was to examine the influence of shift work on obesity, as well as on sociodemographic variables, anthropometric measurements, and lifestyle habits in individuals working this type of schedule. METHODS: An observational, cross-sectional, descriptive study involving 53,053 workers from various labour sectors across several Spanish autonomous communities was conducted. It included 31,753 men (17,527 of them working shifts) and 21,300 women (11,281 of them working shifts). The relationship between shift work and obesity was examined, as well as its association with sex, age, social class, education level, smoking, alcohol consumption, sedentary behaviour, and unhealthy diet. RESULTS: Obesity showed higher prevalence and mean values among shift workers across all four formulas used (BMI obesity, WtHR high, CUN BAE obesity, METS-VF high). All variables related to unhealthy lifestyle habits revealed a significantly greater prevalence among shift workers, with high statistical significance (p < 0.001). Age, sex, and social class affected the risk of obesity, with a greater prevalence observed in shift workers compared to non-shift workers (p < 0.001). Men had a higher risk than women, with an OR ranging from 1.17 (1.12-1.21) for BMI obesity to 7.45 (6.71-8.20) for METS-VF high. CONCLUSIONS: Shift workers exhibit a higher prevalence of obesity and unhealthy lifestyle habits, with men at greater risk. The variables that most significantly increase the risk of obesity include age, physical inactivity, low adherence to the Mediterranean diet, and alcohol consumption.
  

• 
  1.

  Córdoba García R, Camarelles Guillem F, Muñoz Seco E, Gómez Puente JM, San José Arango J, Ramírez Manent JI, Martín Cantera C, Giménez MDC, Revenga Frauca J, Egea Ronda A, Cervigón Portaencasa R, Rodriguez Benito L. PAPPS expert group: Lifestyle recommendations. Atencion primaria [Internet]. Spain; 2024 Nov.;56 Suppl 1:103133-. https://pubmed.ncbi.nlm.nih.gov/39613361

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  We present the recommendations of the Preventive Activities and Health Promotion Programme (PAPPS) of the semFYC (Spanish Society of Family and Community Medicine) to promote healthy lifestyles using intervention methodology, and preventive actions against tobacco and alcohol use, healthy eating, physical activity in leisure time, prevention of traffic accidents, and child restraint systems. The recommendations have been updated, and new aspects highlighted, such as the definition of low-risk alcohol consumption, and the references have been updated. For the main recommendations, we include specific tables showing the quality of the evidence and the strength of the recommendation.

  @article{cordobagarcia2024papps,
  abstract = {We present the recommendations of the Preventive Activities and Health Promotion Programme (PAPPS) of the semFYC (Spanish Society of Family and Community Medicine) to promote healthy lifestyles using intervention methodology, and preventive actions against tobacco and alcohol use, healthy eating, physical activity in leisure time, prevention of traffic accidents, and child restraint systems. The recommendations have been updated, and new aspects highlighted, such as the definition of low-risk alcohol consumption, and the references have been updated. For the main recommendations, we include specific tables showing the quality of the evidence and the strength of the recommendation.},
  address = {Spain},
  author = {Córdoba García, Rodrigo and Camarelles Guillem, Francisco and Muñoz Seco, Elena and Gómez Puente, Juana M and San José Arango, Joaquín and Ramírez Manent, Jose Ignacio and Martín Cantera, Carlos and Giménez, María Del Campo and Revenga Frauca, Juan and Egea Ronda, Ana and Cervigón Portaencasa, Raquel and Rodriguez Benito, Laura},
  journal = {Atencion primaria},
  keywords = {grapp-caib},
  month = {nov},
  pages = {103133--103133},
  title = {PAPPS expert group: Lifestyle recommendations},
  volume = {56 Suppl 1},
  year = 2024
  }
  

  %0 Journal Article
  %1 cordobagarcia2024papps
  %A Córdoba García, Rodrigo
  %A Camarelles Guillem, Francisco
  %A Muñoz Seco, Elena
  %A Gómez Puente, Juana M
  %A San José Arango, Joaquín
  %A Ramírez Manent, Jose Ignacio
  %A Martín Cantera, Carlos
  %A Giménez, María Del Campo
  %A Revenga Frauca, Juan
  %A Egea Ronda, Ana
  %A Cervigón Portaencasa, Raquel
  %A Rodriguez Benito, Laura
  %C Spain
  %D 2024
  %J Atencion primaria
  %P 103133--103133
  %R 10.1016/j.aprim.2024.103133
  %T PAPPS expert group: Lifestyle recommendations
  %U https://pubmed.ncbi.nlm.nih.gov/39613361
  %V 56 Suppl 1
  %X We present the recommendations of the Preventive Activities and Health Promotion Programme (PAPPS) of the semFYC (Spanish Society of Family and Community Medicine) to promote healthy lifestyles using intervention methodology, and preventive actions against tobacco and alcohol use, healthy eating, physical activity in leisure time, prevention of traffic accidents, and child restraint systems. The recommendations have been updated, and new aspects highlighted, such as the definition of low-risk alcohol consumption, and the references have been updated. For the main recommendations, we include specific tables showing the quality of the evidence and the strength of the recommendation.
  

• 
  1.

  Forteza-Albertí JF, Rico Y, Leiva A, Pericas P, Gual-Capllonch F, Rivas-Catoni L, Gutiérrez García-Moreno L, Rodríguez Fernández A, Peral Disdier V. Left atrial strain in patients without cardiovascular disease: uncovering influencing and related factors. Cardiovascular ultrasound [Internet]. England; 2024 Nov.;22(1):15-. https://pubmed.ncbi.nlm.nih.gov/39511600

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Despite its proven prognostic value in different contexts, the precise implications of left atrial strain (LAS) assessment throughout different phases of the atrial cycle remain uncertain. A direct correlation between left atrial reservoir strain (LARS) and left ventricular global longitudinal strain (GLS) has been consistently demonstrated in several studies involving patients with various heart diseases. The objective of our study is to identify factors directly associated with LARS, left atrial conduction strain (LACS) and left atrial booster strain (LABS) in patients without cardiovascular (CV) disease. METHODS: Transthoracic echocardiographic examinations in patients without CV disease were prospectively selected in two tertiary hospitals echocardiography labs for clinical purposes. LAS, maximal and minimal left atrial (LA) volumes and left atrial ejection fraction (LAEF) were measured using the two-dimensional strain analysis package provided by the EchoPAC Plugging workstation (AFI LA). RESULTS: A total of 196 cases were included, median age of 54 (45-62) with 85 (43%) being men. The mean left ventricular ejection fraction (LVEF) was 61% ± 5, and the median GLS was - 18% (-17 to -20). Median indexed maximum volume of left atrium (LAVI) was 27 ml/m(2) (22-31), and LAEF was 64% (58-70). The mean LARS biplane was 35,1% ± 8. Notably, LARS was greater in the 2-chamber view (36,1% ± 10) compared to the 4-chamber view (34,1% ± 8 p < 0,05). The multivariate analysis of LARS revealed that sex, GLS, LAEF and e'(mean) are independently correlated with LARS. Multivariate analysis of LACS showed independent correlations between LACS and age, GLS, LAEF, E/A ratio and e'(mean). Conversely, the multivariate analysis of LABS demonstrated significant correlations among A wave, e'(mean), and left atrial stiffness index (LASI). CONCLUSIONS: In patients without CV disease, GLS emerges as a crucial determinant of LARS and LACS. LAEF and e'(mean) are directly and independently related to both LARS and LACS. LARS (univariate) and LACS (multivariate) exhibited a decline with older age in individuals without CV disease.

  @article{fortezaalberti2024atrial,
  abstract = {BACKGROUND: Despite its proven prognostic value in different contexts, the precise implications of left atrial strain (LAS) assessment throughout different phases of the atrial cycle remain uncertain. A direct correlation between left atrial reservoir strain (LARS) and left ventricular global longitudinal strain (GLS) has been consistently demonstrated in several studies involving patients with various heart diseases. The objective of our study is to identify factors directly associated with LARS, left atrial conduction strain (LACS) and left atrial booster strain (LABS) in patients without cardiovascular (CV) disease. METHODS: Transthoracic echocardiographic examinations in patients without CV disease were prospectively selected in two tertiary hospitals echocardiography labs for clinical purposes. LAS, maximal and minimal left atrial (LA) volumes and left atrial ejection fraction (LAEF) were measured using the two-dimensional strain analysis package provided by the EchoPAC Plugging workstation (AFI LA). RESULTS: A total of 196 cases were included, median age of 54 (45-62) with 85 (43%) being men. The mean left ventricular ejection fraction (LVEF) was 61% ± 5, and the median GLS was - 18% (-17 to -20). Median indexed maximum volume of left atrium (LAVI) was 27 ml/m(2) (22-31), and LAEF was 64% (58-70). The mean LARS biplane was 35,1% ± 8. Notably, LARS was greater in the 2-chamber view (36,1% ± 10) compared to the 4-chamber view (34,1% ± 8 p < 0,05). The multivariate analysis of LARS revealed that sex, GLS, LAEF and e'(mean) are independently correlated with LARS. Multivariate analysis of LACS showed independent correlations between LACS and age, GLS, LAEF, E/A ratio and e'(mean). Conversely, the multivariate analysis of LABS demonstrated significant correlations among A wave, e'(mean), and left atrial stiffness index (LASI). CONCLUSIONS: In patients without CV disease, GLS emerges as a crucial determinant of LARS and LACS. LAEF and e'(mean) are directly and independently related to both LARS and LACS. LARS (univariate) and LACS (multivariate) exhibited a decline with older age in individuals without CV disease.},
  address = {England},
  author = {Forteza-Albertí, José Francisco and Rico, Yolanda and Leiva, Alfonso and Pericas, Pere and Gual-Capllonch, Francisco and Rivas-Catoni, Lisandro and Gutiérrez García-Moreno, Laura and Rodríguez Fernández, Antonio and Peral Disdier, Vicente},
  journal = {Cardiovascular ultrasound},
  keywords = {grapp-caib},
  month = {nov},
  number = 1,
  pages = {15--15},
  title = {Left atrial strain in patients without cardiovascular disease: uncovering influencing and related factors},
  volume = 22,
  year = 2024
  }
  

  %0 Journal Article
  %1 fortezaalberti2024atrial
  %A Forteza-Albertí, José Francisco
  %A Rico, Yolanda
  %A Leiva, Alfonso
  %A Pericas, Pere
  %A Gual-Capllonch, Francisco
  %A Rivas-Catoni, Lisandro
  %A Gutiérrez García-Moreno, Laura
  %A Rodríguez Fernández, Antonio
  %A Peral Disdier, Vicente
  %C England
  %D 2024
  %J Cardiovascular ultrasound
  %N 1
  %P 15--15
  %R 10.1186/s12947-024-00334-y
  %T Left atrial strain in patients without cardiovascular disease: uncovering influencing and related factors
  %U https://pubmed.ncbi.nlm.nih.gov/39511600
  %V 22
  %X BACKGROUND: Despite its proven prognostic value in different contexts, the precise implications of left atrial strain (LAS) assessment throughout different phases of the atrial cycle remain uncertain. A direct correlation between left atrial reservoir strain (LARS) and left ventricular global longitudinal strain (GLS) has been consistently demonstrated in several studies involving patients with various heart diseases. The objective of our study is to identify factors directly associated with LARS, left atrial conduction strain (LACS) and left atrial booster strain (LABS) in patients without cardiovascular (CV) disease. METHODS: Transthoracic echocardiographic examinations in patients without CV disease were prospectively selected in two tertiary hospitals echocardiography labs for clinical purposes. LAS, maximal and minimal left atrial (LA) volumes and left atrial ejection fraction (LAEF) were measured using the two-dimensional strain analysis package provided by the EchoPAC Plugging workstation (AFI LA). RESULTS: A total of 196 cases were included, median age of 54 (45-62) with 85 (43%) being men. The mean left ventricular ejection fraction (LVEF) was 61% ± 5, and the median GLS was - 18% (-17 to -20). Median indexed maximum volume of left atrium (LAVI) was 27 ml/m(2) (22-31), and LAEF was 64% (58-70). The mean LARS biplane was 35,1% ± 8. Notably, LARS was greater in the 2-chamber view (36,1% ± 10) compared to the 4-chamber view (34,1% ± 8 p < 0,05). The multivariate analysis of LARS revealed that sex, GLS, LAEF and e'(mean) are independently correlated with LARS. Multivariate analysis of LACS showed independent correlations between LACS and age, GLS, LAEF, E/A ratio and e'(mean). Conversely, the multivariate analysis of LABS demonstrated significant correlations among A wave, e'(mean), and left atrial stiffness index (LASI). CONCLUSIONS: In patients without CV disease, GLS emerges as a crucial determinant of LARS and LACS. LAEF and e'(mean) are directly and independently related to both LARS and LACS. LARS (univariate) and LACS (multivariate) exhibited a decline with older age in individuals without CV disease.
  

• 
  1.

  Roldán-Espínola L, Riera-Serra P, Roca M, García-Toro M, Coronado-Simsic V, Castro A, Navarra-Ventura G, Vilagut G, Alayo I, Ballester L, Blasco MJ, Almenara J, Cebrià AI, Echeburúa E, Gabilondo A, Lagares C, Piqueras JA, Soto-Sanz V, Mortier P, Kessler RC, Alonso J, Forteza-Rey I, Gili M. Depression and lifestyle among university students: A one-year follow-up study. The European Journal of Psychiatry [Internet]. 2024;38(3):100250. https://www.sciencedirect.com/science/article/pii/S0213616324000016

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Background and objectives University stage is a risk period for development of mental disorders and major depression disorder (MDD) is one of the most prevalent disorders. There is increasing evidence about the influence of lifestyle factors on depression onset and maintenance, nevertheless there is a great heterogeneity between analyzed lifestyle factors and few longitudinal studies has been carried out. The current study aims to longitudinally assess the influence of lifestyle on MDD courses among first-year university students. Methods First-onset and persistence of MDD and lifestyle trajectories are measured using baseline and 12-months follow-up online surveys. Multivariate logistic regression analyses were performed to study longitudinal risk/protective associations between lifestyle factors and MDD. Results 1,292 participants were included. Mean age of included participants at baseline was 18.5 (SD= 1.16) and 75.7 % were female. First-onset and persistence of MDD at T2 were 10.3 % and 38.9 % respectively. Maintenance of healthy sleep (Adjusted Odds Ratio (aOR) = 0.26; 95 % CI =0.12–0.58) and physical activity (aOR = 0.24; 95 % CI = 0.10–0.58) were protectively associated against MDD first-onset. Adoption of healthy levels of social support showed a protective effect against MDD persistence (aOR = 0.17; 95 % CI = 0.07–0.44). Conclusions Lifestyle should be considered in order to improve depression prevention strategies among university students. Sleep, physical activity, and social support seem to have a crucial role in the onset and persistence of depression among this population.

  @article{RN65,
  abstract = {Background and objectives University stage is a risk period for development of mental disorders and major depression disorder (MDD) is one of the most prevalent disorders. There is increasing evidence about the influence of lifestyle factors on depression onset and maintenance, nevertheless there is a great heterogeneity between analyzed lifestyle factors and few longitudinal studies has been carried out. The current study aims to longitudinally assess the influence of lifestyle on MDD courses among first-year university students. Methods First-onset and persistence of MDD and lifestyle trajectories are measured using baseline and 12-months follow-up online surveys. Multivariate logistic regression analyses were performed to study longitudinal risk/protective associations between lifestyle factors and MDD. Results 1,292 participants were included. Mean age of included participants at baseline was 18.5 (SD= 1.16) and 75.7 % were female. First-onset and persistence of MDD at T2 were 10.3 % and 38.9 % respectively. Maintenance of healthy sleep (Adjusted Odds Ratio (aOR) = 0.26; 95 % CI =0.12–0.58) and physical activity (aOR = 0.24; 95 % CI = 0.10–0.58) were protectively associated against MDD first-onset. Adoption of healthy levels of social support showed a protective effect against MDD persistence (aOR = 0.17; 95 % CI = 0.07–0.44). Conclusions Lifestyle should be considered in order to improve depression prevention strategies among university students. Sleep, physical activity, and social support seem to have a crucial role in the onset and persistence of depression among this population.},
  author = {Roldán-Espínola, Lorenzo and Riera-Serra, Pau and Roca, Miquel and García-Toro, Mauro and Coronado-Simsic, Victoria and Castro, Adoración and Navarra-Ventura, Guillem and Vilagut, Gemma and Alayo, Itxaso and Ballester, Laura and Blasco, María Jesús and Almenara, José and Cebrià, Ana Isabel and Echeburúa, Enrique and Gabilondo, Andrea and Lagares, Carolina and Piqueras, José Antonio and Soto-Sanz, Victoria and Mortier, Philippe and Kessler, Ronald C. and Alonso, Jordi and Forteza-Rey, Inés and Gili, Margalida},
  journal = {The European Journal of Psychiatry},
  keywords = {evisap},
  number = 3,
  pages = 100250,
  title = {Depression and lifestyle among university students: A one-year follow-up study},
  type = {Journal Article},
  volume = 38,
  year = 2024
  }
  

  %0 Journal Article
  %1 RN65
  %A Roldán-Espínola, Lorenzo
  %A Riera-Serra, Pau
  %A Roca, Miquel
  %A García-Toro, Mauro
  %A Coronado-Simsic, Victoria
  %A Castro, Adoración
  %A Navarra-Ventura, Guillem
  %A Vilagut, Gemma
  %A Alayo, Itxaso
  %A Ballester, Laura
  %A Blasco, María Jesús
  %A Almenara, José
  %A Cebrià, Ana Isabel
  %A Echeburúa, Enrique
  %A Gabilondo, Andrea
  %A Lagares, Carolina
  %A Piqueras, José Antonio
  %A Soto-Sanz, Victoria
  %A Mortier, Philippe
  %A Kessler, Ronald C.
  %A Alonso, Jordi
  %A Forteza-Rey, Inés
  %A Gili, Margalida
  %D 2024
  %J The European Journal of Psychiatry
  %N 3
  %P 100250
  %R https://doi.org/10.1016/j.ejpsy.2024.100250
  %T Depression and lifestyle among university students: A one-year follow-up study
  %U https://www.sciencedirect.com/science/article/pii/S0213616324000016
  %V 38
  %X Background and objectives University stage is a risk period for development of mental disorders and major depression disorder (MDD) is one of the most prevalent disorders. There is increasing evidence about the influence of lifestyle factors on depression onset and maintenance, nevertheless there is a great heterogeneity between analyzed lifestyle factors and few longitudinal studies has been carried out. The current study aims to longitudinally assess the influence of lifestyle on MDD courses among first-year university students. Methods First-onset and persistence of MDD and lifestyle trajectories are measured using baseline and 12-months follow-up online surveys. Multivariate logistic regression analyses were performed to study longitudinal risk/protective associations between lifestyle factors and MDD. Results 1,292 participants were included. Mean age of included participants at baseline was 18.5 (SD= 1.16) and 75.7 % were female. First-onset and persistence of MDD at T2 were 10.3 % and 38.9 % respectively. Maintenance of healthy sleep (Adjusted Odds Ratio (aOR) = 0.26; 95 % CI =0.12–0.58) and physical activity (aOR = 0.24; 95 % CI = 0.10–0.58) were protectively associated against MDD first-onset. Adoption of healthy levels of social support showed a protective effect against MDD persistence (aOR = 0.17; 95 % CI = 0.07–0.44). Conclusions Lifestyle should be considered in order to improve depression prevention strategies among university students. Sleep, physical activity, and social support seem to have a crucial role in the onset and persistence of depression among this population.
  

• 
  1.

  Bescos R, Gallardo-Alfaro L, Ashor A, Rizzolo-Brime L, Siervo M, Casas-Agustench P. Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis. Free radical biology & medicine [Internet]. United States; 2024 Nov.;226:70-83. https://pubmed.ncbi.nlm.nih.gov/39522567

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO(3)(-)) and nitrite (NO(2)(-)) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO(3)(-) and NO(2)(-) using the chemiluminescence technique, were included. Mean plasma NO(3)(-) and NO(2)(-) concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO(3)(-) and NO(2)(-) concentrations in individuals with cardiometabolic risk (NO(3)(-): 21.2 μmol/L; 95 % CI, 13.4-29.0; NO(2)(-): 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO(3)(-): 33.9 μmol/L; 95 % CI, 29.9-37.9; NO(2)(-): 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO(3)(-): 43.0 μmol/L; 95 % CI, 13.2-72.9; NO(2)(-): 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO(3)(-) and NO(2)(-) concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO(3)(-), but no NO(2)(-), concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO(3)(-) and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO(3)(-) and NO(2)(-) concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO(3)(-) showed a significant positive association with DBP.

  @article{bescos2024nitrate,
  abstract = {In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO(3)(-)) and nitrite (NO(2)(-)) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO(3)(-) and NO(2)(-) using the chemiluminescence technique, were included. Mean plasma NO(3)(-) and NO(2)(-) concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO(3)(-) and NO(2)(-) concentrations in individuals with cardiometabolic risk (NO(3)(-): 21.2 μmol/L; 95 % CI, 13.4-29.0; NO(2)(-): 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO(3)(-): 33.9 μmol/L; 95 % CI, 29.9-37.9; NO(2)(-): 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO(3)(-): 43.0 μmol/L; 95 % CI, 13.2-72.9; NO(2)(-): 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO(3)(-) and NO(2)(-) concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO(3)(-), but no NO(2)(-), concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO(3)(-) and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO(3)(-) and NO(2)(-) concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO(3)(-) showed a significant positive association with DBP.},
  address = {United States},
  author = {Bescos, Raul and Gallardo-Alfaro, Laura and Ashor, Ammar and Rizzolo-Brime, Lucia and Siervo, Mario and Casas-Agustench, Patricia},
  journal = {Free radical biology & medicine},
  keywords = {grapp-caib},
  month = {nov},
  pages = {70--83},
  title = {Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis},
  volume = 226,
  year = 2024
  }
  

  %0 Journal Article
  %1 bescos2024nitrate
  %A Bescos, Raul
  %A Gallardo-Alfaro, Laura
  %A Ashor, Ammar
  %A Rizzolo-Brime, Lucia
  %A Siervo, Mario
  %A Casas-Agustench, Patricia
  %C United States
  %D 2024
  %J Free radical biology & medicine
  %P 70--83
  %R 10.1016/j.freeradbiomed.2024.11.010
  %T Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure - A systematic review and meta-analysis
  %U https://pubmed.ncbi.nlm.nih.gov/39522567
  %V 226
  %X In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO(3)(-)) and nitrite (NO(2)(-)) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO(3)(-) and NO(2)(-) using the chemiluminescence technique, were included. Mean plasma NO(3)(-) and NO(2)(-) concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO(3)(-) and NO(2)(-) concentrations in individuals with cardiometabolic risk (NO(3)(-): 21.2 μmol/L; 95 % CI, 13.4-29.0; NO(2)(-): 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO(3)(-): 33.9 μmol/L; 95 % CI, 29.9-37.9; NO(2)(-): 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO(3)(-): 43.0 μmol/L; 95 % CI, 13.2-72.9; NO(2)(-): 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO(3)(-) and NO(2)(-) concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO(3)(-), but no NO(2)(-), concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO(3)(-) and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO(3)(-) and NO(2)(-) concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO(3)(-) showed a significant positive association with DBP.
  

• 
  1.

  García-Buades ME, Montañez-Juan M, Blahopoulou J, Ortiz-Bonnin S, Chela-Alvarez X, Bulilete O, Llobera J. Psychosocial Work Factors, Job Stress, and Self-Rated Health Among Hotel Housekeepers. Workplace health & safety [Internet]. United States; 2024 Oct.;:21650799241282787-. https://pubmed.ncbi.nlm.nih.gov/39475436

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Hotel housekeeping is widely recognized as a poor-quality job due to its high demands and limited resources. Hotel housekeepers (HHs) face both hard physical work and mentally demanding conditions, yet psychosocial factors in this feminized and precarious occupation remain under-researched. To address this gap, this study examines HHs' exposure to psychosocial factors at work and their impact on job stress and self-rated health. METHODS: A cross-sectional survey of a random sample of 926 HHs in the Balearic Islands (Spain) assessed job stress, self-rated health, psychosocial factors (job demands and resources), and sociodemographic variables using the Copenhagen Psychosocial Questionnaire II (COPSOQ-II) and the National Health Survey. Descriptive analysis and hierarchical linear regression models were applied. RESULTS: The prevalence of job stress was 61.1% (95% confidence interval [CI] = [57.8%, 64.1%]), while the prevalence of poor self-rated health was 59.9% (95% CI = [56.6%, 62.9%]). Hotel housekeepers were highly exposed to job demands such as intense work pace, job-specific stressors, work-life conflict, and emotional demands; highly available job resources were role clarity, task meaning, and social support. Regression models revealed work pace, work-life conflict, nationality, and weak leader support as key predictors of job stress; and work-life conflict and leadership quality as key predictors of self-rated health. CONCLUSION/APPLICATION TO PRACTICE: Although considered an eminently physical job, psychosocial work factors play a key role in explaining HHs' job stress and self-rated health. Occupational health professionals should design workplace interventions to reduce work pace, mitigate work-life conflict, and enhance resources such as leader support, sense of community, and leadership quality.

  @article{garciabuades2024psychosocial,
  abstract = {BACKGROUND: Hotel housekeeping is widely recognized as a poor-quality job due to its high demands and limited resources. Hotel housekeepers (HHs) face both hard physical work and mentally demanding conditions, yet psychosocial factors in this feminized and precarious occupation remain under-researched. To address this gap, this study examines HHs' exposure to psychosocial factors at work and their impact on job stress and self-rated health. METHODS: A cross-sectional survey of a random sample of 926 HHs in the Balearic Islands (Spain) assessed job stress, self-rated health, psychosocial factors (job demands and resources), and sociodemographic variables using the Copenhagen Psychosocial Questionnaire II (COPSOQ-II) and the National Health Survey. Descriptive analysis and hierarchical linear regression models were applied. RESULTS: The prevalence of job stress was 61.1% (95% confidence interval [CI] = [57.8%, 64.1%]), while the prevalence of poor self-rated health was 59.9% (95% CI = [56.6%, 62.9%]). Hotel housekeepers were highly exposed to job demands such as intense work pace, job-specific stressors, work-life conflict, and emotional demands; highly available job resources were role clarity, task meaning, and social support. Regression models revealed work pace, work-life conflict, nationality, and weak leader support as key predictors of job stress; and work-life conflict and leadership quality as key predictors of self-rated health. CONCLUSION/APPLICATION TO PRACTICE: Although considered an eminently physical job, psychosocial work factors play a key role in explaining HHs' job stress and self-rated health. Occupational health professionals should design workplace interventions to reduce work pace, mitigate work-life conflict, and enhance resources such as leader support, sense of community, and leadership quality.},
  address = {United States},
  author = {García-Buades, M Esther and Montañez-Juan, Maribel and Blahopoulou, Joanna and Ortiz-Bonnin, Silvia and Chela-Alvarez, Xènia and Bulilete, Oana and Llobera, Joan},
  journal = {Workplace health & safety},
  keywords = {grapp-caib},
  month = {oct},
  pages = {21650799241282787--21650799241282787},
  title = {Psychosocial Work Factors, Job Stress, and Self-Rated Health Among Hotel Housekeepers},
  year = 2024
  }
  

  %0 Journal Article
  %1 garciabuades2024psychosocial
  %A García-Buades, M Esther
  %A Montañez-Juan, Maribel
  %A Blahopoulou, Joanna
  %A Ortiz-Bonnin, Silvia
  %A Chela-Alvarez, Xènia
  %A Bulilete, Oana
  %A Llobera, Joan
  %C United States
  %D 2024
  %J Workplace health & safety
  %P 21650799241282787--21650799241282787
  %R 10.1177/21650799241282787
  %T Psychosocial Work Factors, Job Stress, and Self-Rated Health Among Hotel Housekeepers
  %U https://pubmed.ncbi.nlm.nih.gov/39475436
  %X BACKGROUND: Hotel housekeeping is widely recognized as a poor-quality job due to its high demands and limited resources. Hotel housekeepers (HHs) face both hard physical work and mentally demanding conditions, yet psychosocial factors in this feminized and precarious occupation remain under-researched. To address this gap, this study examines HHs' exposure to psychosocial factors at work and their impact on job stress and self-rated health. METHODS: A cross-sectional survey of a random sample of 926 HHs in the Balearic Islands (Spain) assessed job stress, self-rated health, psychosocial factors (job demands and resources), and sociodemographic variables using the Copenhagen Psychosocial Questionnaire II (COPSOQ-II) and the National Health Survey. Descriptive analysis and hierarchical linear regression models were applied. RESULTS: The prevalence of job stress was 61.1% (95% confidence interval [CI] = [57.8%, 64.1%]), while the prevalence of poor self-rated health was 59.9% (95% CI = [56.6%, 62.9%]). Hotel housekeepers were highly exposed to job demands such as intense work pace, job-specific stressors, work-life conflict, and emotional demands; highly available job resources were role clarity, task meaning, and social support. Regression models revealed work pace, work-life conflict, nationality, and weak leader support as key predictors of job stress; and work-life conflict and leadership quality as key predictors of self-rated health. CONCLUSION/APPLICATION TO PRACTICE: Although considered an eminently physical job, psychosocial work factors play a key role in explaining HHs' job stress and self-rated health. Occupational health professionals should design workplace interventions to reduce work pace, mitigate work-life conflict, and enhance resources such as leader support, sense of community, and leadership quality.
  

• 
  1.

  Rico-Blazquez M, Esteban-Sepúlveda S, Sánchez-Ruano R, Aritztegui-Echenique AM, Artigues-Barbera EM, Brito-Brito PR, Casado-Ramirez E, Cidoncha-Moreno M Ángeles, Fabregat-Julve MI, Feria-Raposo I, Hernandez-Pascual M, Lozano-Hernández C, Moreno-Casbas MT, Otones-Reyes P, Palmar-Santos AM, Pedraz-Marcos A, Romero-Rodriguez EM, Solé-Agustí MC, Taltavull-Aparicio JM, Vidal-Thomas MC, Gonzalez-Chorda VM, Group C. Impact of the COVID-19 pandemic on the self-care and health condition of the older adults. CUIDAMOS+75. A mixed methods study protocol. Frontiers in public health [Internet]. Switzerland; 2024 Jun.;12:1389641-. https://pubmed.ncbi.nlm.nih.gov/38952731

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  AIMS: To assess the impact of the COVID-19 pandemic on the health condition of people ≥75 years of age and on their family caregivers in Spain. DESIGN: Multicentric, mixed method concurrent study. METHODS: This work, which will be conducted within the primary care setting in 11 administrative regions of Spain, will include three coordinated studies with different methodologies. The first is a population-based cohort study that will use real-life data to analyze the rates and evolution of health needs, care provision, and services utilization before, during, and after the pandemic. The second is a prospective cohort study with 18 months of follow-up that will evaluate the impact of COVID-19 disease on mortality, frailty, functional and cognitive capacity, and quality of life of the participants. Finally, the third will be a qualitative study with a critical social approach to understand and interpret the social, political, and economic dimensions associated with the use of health services during the pandemic. We have followed the SPIRIT Checklist to address trial protocol and related documents. This research is being funded by the Instituto de Salud Carlos III since 2021 and was approved by its ethics committee (June 2022). DISCUSSION: The study findings will reveal the long-term impact of the COVID-19 pandemic on the older adults and their caregivers. This information will serve policymakers to adapt health policies to the needs of this population in situations of maximum stress, such as that produced by the COVID-19 pandemic. TRIAL REGISTRATION: Identifier: NCT05249868 [ClinicalTrials.gov].

  @article{ricoblazquez2024impact,
  abstract = {AIMS: To assess the impact of the COVID-19 pandemic on the health condition of people ≥75 years of age and on their family caregivers in Spain. DESIGN: Multicentric, mixed method concurrent study. METHODS: This work, which will be conducted within the primary care setting in 11 administrative regions of Spain, will include three coordinated studies with different methodologies. The first is a population-based cohort study that will use real-life data to analyze the rates and evolution of health needs, care provision, and services utilization before, during, and after the pandemic. The second is a prospective cohort study with 18 months of follow-up that will evaluate the impact of COVID-19 disease on mortality, frailty, functional and cognitive capacity, and quality of life of the participants. Finally, the third will be a qualitative study with a critical social approach to understand and interpret the social, political, and economic dimensions associated with the use of health services during the pandemic. We have followed the SPIRIT Checklist to address trial protocol and related documents. This research is being funded by the Instituto de Salud Carlos III since 2021 and was approved by its ethics committee (June 2022). DISCUSSION: The study findings will reveal the long-term impact of the COVID-19 pandemic on the older adults and their caregivers. This information will serve policymakers to adapt health policies to the needs of this population in situations of maximum stress, such as that produced by the COVID-19 pandemic. TRIAL REGISTRATION: Identifier: NCT05249868 [ClinicalTrials.gov].},
  address = {Switzerland},
  author = {Rico-Blazquez, Milagros and Esteban-Sepúlveda, Silvia and Sánchez-Ruano, Raquel and Aritztegui-Echenique, Ana María and Artigues-Barbera, Eva María and Brito-Brito, Pedro Ruymán and Casado-Ramirez, Elvira and Cidoncha-Moreno, María Ángeles and Fabregat-Julve, María Inmaculada and Feria-Raposo, Isabel and Hernandez-Pascual, Montserrat and Lozano-Hernández, Cristina and Moreno-Casbas, María Teresa and Otones-Reyes, Pedro and Palmar-Santos, Ana María and Pedraz-Marcos, Azucena and Romero-Rodriguez, Esperanza María and Solé-Agustí, María Cristina and Taltavull-Aparicio, Joana María and Vidal-Thomas, María Clara and Gonzalez-Chorda, Víctor Manuel and Group, Cuidamos+75},
  journal = {Frontiers in public health},
  keywords = {grapp-caib},
  month = {jun},
  pages = {1389641--1389641},
  title = {Impact of the COVID-19 pandemic on the self-care and health condition of the older adults. CUIDAMOS+75. A mixed methods study protocol},
  volume = 12,
  year = 2024
  }
  

  %0 Journal Article
  %1 ricoblazquez2024impact
  %A Rico-Blazquez, Milagros
  %A Esteban-Sepúlveda, Silvia
  %A Sánchez-Ruano, Raquel
  %A Aritztegui-Echenique, Ana María
  %A Artigues-Barbera, Eva María
  %A Brito-Brito, Pedro Ruymán
  %A Casado-Ramirez, Elvira
  %A Cidoncha-Moreno, María Ángeles
  %A Fabregat-Julve, María Inmaculada
  %A Feria-Raposo, Isabel
  %A Hernandez-Pascual, Montserrat
  %A Lozano-Hernández, Cristina
  %A Moreno-Casbas, María Teresa
  %A Otones-Reyes, Pedro
  %A Palmar-Santos, Ana María
  %A Pedraz-Marcos, Azucena
  %A Romero-Rodriguez, Esperanza María
  %A Solé-Agustí, María Cristina
  %A Taltavull-Aparicio, Joana María
  %A Vidal-Thomas, María Clara
  %A Gonzalez-Chorda, Víctor Manuel
  %A Group, Cuidamos+75
  %C Switzerland
  %D 2024
  %J Frontiers in public health
  %P 1389641--1389641
  %R 10.3389/fpubh.2024.1389641
  %T Impact of the COVID-19 pandemic on the self-care and health condition of the older adults. CUIDAMOS+75. A mixed methods study protocol
  %U https://pubmed.ncbi.nlm.nih.gov/38952731
  %V 12
  %X AIMS: To assess the impact of the COVID-19 pandemic on the health condition of people ≥75 years of age and on their family caregivers in Spain. DESIGN: Multicentric, mixed method concurrent study. METHODS: This work, which will be conducted within the primary care setting in 11 administrative regions of Spain, will include three coordinated studies with different methodologies. The first is a population-based cohort study that will use real-life data to analyze the rates and evolution of health needs, care provision, and services utilization before, during, and after the pandemic. The second is a prospective cohort study with 18 months of follow-up that will evaluate the impact of COVID-19 disease on mortality, frailty, functional and cognitive capacity, and quality of life of the participants. Finally, the third will be a qualitative study with a critical social approach to understand and interpret the social, political, and economic dimensions associated with the use of health services during the pandemic. We have followed the SPIRIT Checklist to address trial protocol and related documents. This research is being funded by the Instituto de Salud Carlos III since 2021 and was approved by its ethics committee (June 2022). DISCUSSION: The study findings will reveal the long-term impact of the COVID-19 pandemic on the older adults and their caregivers. This information will serve policymakers to adapt health policies to the needs of this population in situations of maximum stress, such as that produced by the COVID-19 pandemic. TRIAL REGISTRATION: Identifier: NCT05249868 [ClinicalTrials.gov].
  

• 
  1.

  Unda Villafuerte F, Llobera Cànaves J, Estela Mantolan A, Bassante Flores P, Rigo Carratalà F, Requena Hernández A, Oliver Oliver B, Pou Bordoy J, Moreno Sancho ML, Leiva A, Lorente Montalvo P, Group M. Effectiveness of medication self-management, self-monitoring and a lifestyle intervention on hypertension in poorly controlled patients: The MEDICHY randomized trial. Frontiers in cardiovascular medicine [Internet]. Switzerland; 2024 May;11:1355037-. https://pubmed.ncbi.nlm.nih.gov/38836068

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Uncontrolled hypertension is a common problem worldwide, despite the availability of many effective antihypertensive drugs and lifestyle interventions. We assessed the efficacy of a multi-component intervention in individuals with uncontrolled hypertension in a primary care setting. METHODS: This study was a randomized, multicenter, parallel, two-arm, single-blind controlled trial performed in primary healthcare centers in Mallorca (Spain). All participants were 35 to 75-years-old and had poorly controlled hypertension. Patients were randomly assigned in a 1:1 ratio to a control group (usual care) or an intervention group (self-monitoring of blood pressure, self-titration of hypertensive medications, dietary interventions, and physical activity interventions). The primary outcome was decrease in the mean SBP at 6 months relative to baseline. RESULTS: A total of 153 participants were randomized to an intervention group (77) or a control group (76). After 6 months, the intervention group had a significantly lower systolic blood pressure (135.1 mmHg [±14.8] vs. 142.7 mmHg [±15.0], adjusted mean difference: 8.7 mmHg [95% CI: 3.4, 13.9], p < 0.001) and a significantly lower diastolic blood pressure (83.5 mmHg [±8.8] vs. 87.00 mmHg [±9.0], adjusted mean difference: 5.4 [95% CI: 2.9, 7.8], p < 0.0001). The intervention group also had significantly more patients who achieved successful blood pressure control (<140/90 mmHg; 54.4% vs. 32.9%, p = 0.011). DISCUSSION: Self-monitoring of blood pressure in combination with self-management of hypertensive medications, diet, and physical activity in a primary care setting leads to significantly lower blood pressure in patients with poorly controlled hypertension.Clinical Trial Registration: ClinicalTrials.gov, identifier ISRCTN14433778.

  @article{undavillafuerte2024effectiveness,
  abstract = {BACKGROUND: Uncontrolled hypertension is a common problem worldwide, despite the availability of many effective antihypertensive drugs and lifestyle interventions. We assessed the efficacy of a multi-component intervention in individuals with uncontrolled hypertension in a primary care setting. METHODS: This study was a randomized, multicenter, parallel, two-arm, single-blind controlled trial performed in primary healthcare centers in Mallorca (Spain). All participants were 35 to 75-years-old and had poorly controlled hypertension. Patients were randomly assigned in a 1:1 ratio to a control group (usual care) or an intervention group (self-monitoring of blood pressure, self-titration of hypertensive medications, dietary interventions, and physical activity interventions). The primary outcome was decrease in the mean SBP at 6 months relative to baseline. RESULTS: A total of 153 participants were randomized to an intervention group (77) or a control group (76). After 6 months, the intervention group had a significantly lower systolic blood pressure (135.1 mmHg [±14.8] vs. 142.7 mmHg [±15.0], adjusted mean difference: 8.7 mmHg [95% CI: 3.4, 13.9], p < 0.001) and a significantly lower diastolic blood pressure (83.5 mmHg [±8.8] vs. 87.00 mmHg [±9.0], adjusted mean difference: 5.4 [95% CI: 2.9, 7.8], p < 0.0001). The intervention group also had significantly more patients who achieved successful blood pressure control (<140/90 mmHg; 54.4% vs. 32.9%, p = 0.011). DISCUSSION: Self-monitoring of blood pressure in combination with self-management of hypertensive medications, diet, and physical activity in a primary care setting leads to significantly lower blood pressure in patients with poorly controlled hypertension.Clinical Trial Registration: ClinicalTrials.gov, identifier ISRCTN14433778.},
  address = {Switzerland},
  author = {Unda Villafuerte, Fabián and Llobera Cànaves, Joan and Estela Mantolan, Andreu and Bassante Flores, Patricia and Rigo Carratalà, Fernando and Requena Hernández, Ana and Oliver Oliver, Bartolomé and Pou Bordoy, Joan and Moreno Sancho, María Lucía and Leiva, Alfonso and Lorente Montalvo, Patricia and Group, MEDICHY},
  journal = {Frontiers in cardiovascular medicine},
  keywords = {grapp-caib},
  month = {may},
  pages = {1355037--1355037},
  title = {Effectiveness of medication self-management, self-monitoring and a lifestyle intervention on hypertension in poorly controlled patients: The MEDICHY randomized trial},
  volume = 11,
  year = 2024
  }
  

  %0 Journal Article
  %1 undavillafuerte2024effectiveness
  %A Unda Villafuerte, Fabián
  %A Llobera Cànaves, Joan
  %A Estela Mantolan, Andreu
  %A Bassante Flores, Patricia
  %A Rigo Carratalà, Fernando
  %A Requena Hernández, Ana
  %A Oliver Oliver, Bartolomé
  %A Pou Bordoy, Joan
  %A Moreno Sancho, María Lucía
  %A Leiva, Alfonso
  %A Lorente Montalvo, Patricia
  %A Group, MEDICHY
  %C Switzerland
  %D 2024
  %J Frontiers in cardiovascular medicine
  %P 1355037--1355037
  %R 10.3389/fcvm.2024.1355037
  %T Effectiveness of medication self-management, self-monitoring and a lifestyle intervention on hypertension in poorly controlled patients: The MEDICHY randomized trial
  %U https://pubmed.ncbi.nlm.nih.gov/38836068
  %V 11
  %X BACKGROUND: Uncontrolled hypertension is a common problem worldwide, despite the availability of many effective antihypertensive drugs and lifestyle interventions. We assessed the efficacy of a multi-component intervention in individuals with uncontrolled hypertension in a primary care setting. METHODS: This study was a randomized, multicenter, parallel, two-arm, single-blind controlled trial performed in primary healthcare centers in Mallorca (Spain). All participants were 35 to 75-years-old and had poorly controlled hypertension. Patients were randomly assigned in a 1:1 ratio to a control group (usual care) or an intervention group (self-monitoring of blood pressure, self-titration of hypertensive medications, dietary interventions, and physical activity interventions). The primary outcome was decrease in the mean SBP at 6 months relative to baseline. RESULTS: A total of 153 participants were randomized to an intervention group (77) or a control group (76). After 6 months, the intervention group had a significantly lower systolic blood pressure (135.1 mmHg [±14.8] vs. 142.7 mmHg [±15.0], adjusted mean difference: 8.7 mmHg [95% CI: 3.4, 13.9], p < 0.001) and a significantly lower diastolic blood pressure (83.5 mmHg [±8.8] vs. 87.00 mmHg [±9.0], adjusted mean difference: 5.4 [95% CI: 2.9, 7.8], p < 0.0001). The intervention group also had significantly more patients who achieved successful blood pressure control (<140/90 mmHg; 54.4% vs. 32.9%, p = 0.011). DISCUSSION: Self-monitoring of blood pressure in combination with self-management of hypertensive medications, diet, and physical activity in a primary care setting leads to significantly lower blood pressure in patients with poorly controlled hypertension.Clinical Trial Registration: ClinicalTrials.gov, identifier ISRCTN14433778.
  

• 
  1.

  Abad-Corpa E, Rich-Ruiz M, Sánchez-López D, Solano Ruiz C, Casado-Ramírez E, Arregui-Gallego B, Moreno-Casbas MT, Muñoz-Jiménez D, Vidal-Thomàs MC, Company-Sancho MC, Orts-Cortés MI. Learning, internalisation and integration of the COVID-19 pandemic in healthcare workers: A qualitative document analysis. Nursing inquiry [Internet]. Australia; 2024 Oct.;31(4):e12673-e12673. https://pubmed.ncbi.nlm.nih.gov/39297396

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  The COVID-19 pandemic triggered an unprecedented health crisis that impacted healthcare systems worldwide. This study explores how Spanish healthcare workers learned, internalised and integrated values and work behaviours during the COVID-19 pandemic and their impact on the personal sphere. This documentary research, using images, narratives and audiovisual content, was framed within the interpretative hermeneutic paradigm. Categories and subcategories emerged after a final theoretical sampling that focused on the analysis. Data triangulation between researchers favoured theoretical saturation. A total of 117 images and 27 texts were selected. The analysis identified three stages: bewilderment, seeking functionality in the chaos and integrating chaos into care. The data reflects how the need for security and knowledge, and the exhaustion and frustration caused by the initial working conditions, prompted adaptive responses. These responses involved focusing on problem-solving and strengthening group sentiments and solidarity. Subsequently, the data indicates the acceptance of new structural, organisational and communication aspects. The findings of the analysis will contribute towards finding a framework that can help understand community health crisis events.

  @article{abadcorpa2024learning,
  abstract = {The COVID-19 pandemic triggered an unprecedented health crisis that impacted healthcare systems worldwide. This study explores how Spanish healthcare workers learned, internalised and integrated values and work behaviours during the COVID-19 pandemic and their impact on the personal sphere. This documentary research, using images, narratives and audiovisual content, was framed within the interpretative hermeneutic paradigm. Categories and subcategories emerged after a final theoretical sampling that focused on the analysis. Data triangulation between researchers favoured theoretical saturation. A total of 117 images and 27 texts were selected. The analysis identified three stages: bewilderment, seeking functionality in the chaos and integrating chaos into care. The data reflects how the need for security and knowledge, and the exhaustion and frustration caused by the initial working conditions, prompted adaptive responses. These responses involved focusing on problem-solving and strengthening group sentiments and solidarity. Subsequently, the data indicates the acceptance of new structural, organisational and communication aspects. The findings of the analysis will contribute towards finding a framework that can help understand community health crisis events.},
  address = {Australia},
  author = {Abad-Corpa, Eva and Rich-Ruiz, Manuel and Sánchez-López, Dolores and Solano Ruiz, Carmen and Casado-Ramírez, Elvira and Arregui-Gallego, Beatriz and Moreno-Casbas, María Teresa and Muñoz-Jiménez, Daniel and Vidal-Thomàs, M Clara and Company-Sancho, M Consuelo and Orts-Cortés, María Isabel},
  journal = {Nursing inquiry},
  keywords = {grapp-caib},
  month = {oct},
  number = 4,
  pages = {e12673--e12673},
  title = {Learning, internalisation and integration of the COVID-19 pandemic in healthcare workers: A qualitative document analysis},
  volume = 31,
  year = 2024
  }
  

  %0 Journal Article
  %1 abadcorpa2024learning
  %A Abad-Corpa, Eva
  %A Rich-Ruiz, Manuel
  %A Sánchez-López, Dolores
  %A Solano Ruiz, Carmen
  %A Casado-Ramírez, Elvira
  %A Arregui-Gallego, Beatriz
  %A Moreno-Casbas, María Teresa
  %A Muñoz-Jiménez, Daniel
  %A Vidal-Thomàs, M Clara
  %A Company-Sancho, M Consuelo
  %A Orts-Cortés, María Isabel
  %C Australia
  %D 2024
  %J Nursing inquiry
  %N 4
  %P e12673--e12673
  %R 10.1111/nin.12673
  %T Learning, internalisation and integration of the COVID-19 pandemic in healthcare workers: A qualitative document analysis
  %U https://pubmed.ncbi.nlm.nih.gov/39297396
  %V 31
  %X The COVID-19 pandemic triggered an unprecedented health crisis that impacted healthcare systems worldwide. This study explores how Spanish healthcare workers learned, internalised and integrated values and work behaviours during the COVID-19 pandemic and their impact on the personal sphere. This documentary research, using images, narratives and audiovisual content, was framed within the interpretative hermeneutic paradigm. Categories and subcategories emerged after a final theoretical sampling that focused on the analysis. Data triangulation between researchers favoured theoretical saturation. A total of 117 images and 27 texts were selected. The analysis identified three stages: bewilderment, seeking functionality in the chaos and integrating chaos into care. The data reflects how the need for security and knowledge, and the exhaustion and frustration caused by the initial working conditions, prompted adaptive responses. These responses involved focusing on problem-solving and strengthening group sentiments and solidarity. Subsequently, the data indicates the acceptance of new structural, organisational and communication aspects. The findings of the analysis will contribute towards finding a framework that can help understand community health crisis events.
  

• 
  1.

  Bradfield JP, Kember RL, Ulrich A, Balkiyarova Z, Alyass A, Aris IM, Bell JA, Broadaway KA, Chen Z, Chai JF, Davies NM, Fernandez-Orth D, Bustamante M, Fore R, Ganguli A, Heiskala A, Hottenga JJ, Íñiguez C, Kobes S, Leinonen J, Lowry E, Lyytikainen LP, Mahajan A, Pitkänen N, Schnurr TM, Have CT, Strachan DP, Thiering E, Vogelezang S, Wade KH, Wang CA, Wong A, Holm LA, Chesi A, Choong C, Cruz M, Elliott P, Franks S, Frithioff-Bøjsøe C, Gauderman WJ, Glessner JT, Gilsanz V, Griesman K, Hanson RL, Kaakinen M, Kalkwarf H, Kelly A, Kindler J, Kähönen M, Lanca C, Lappe J, Lee NR, McCormack S, Mentch FD, Mitchell JA, Mononen N, Niinikoski H, Oken E, Pahkala K, Sim X, Teo YY, Baier LJ, van Beijsterveldt T, Adair LS, Boomsma DI, de Geus E, Guxens M, Eriksson JG, Felix JF, Gilliland FD, Biobank PM, Hansen T, Hardy R, Hivert MF, Holm JC, Jaddoe VWV, Järvelin MR, Lehtimäki T, Mackey DA, Meyre D, Mohlke KL, Mykkänen J, Oberfield S, Pennell CE, Perry JRB, Raitakari O, Rivadeneira F, Saw SM, Sebert S, Shepherd JA, Standl M, Sørensen TIA, Timpson NJ, Torrent M, Willemsen G, Hypponen E, Power C, McCarthy MI, Freathy RM, Widén E, others. Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes. Genome Biol. 2024;25(1):22.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~ 56,000 trans-ancestry samples with repeated height measurements from age 5 years to adulthood. We performed genetic analysis on six phenotypes representing the magnitude, timing, and intensity of the pubertal growth spurt. To investigate the lifelong impact of genetic variants associated with pubertal growth trajectories, we performed genetic correlation analyses and phenome-wide association studies in the Penn Medicine BioBank and the UK Biobank. RESULTS: Large-scale growth modeling enables an unprecedented view of adolescent growth across contemporary and 20th-century pediatric cohorts. We identify 26 genome-wide significant loci and leverage trans-ancestry data to perform fine-mapping. Our data reveals genetic relationships between pediatric height growth and health across the life course, with different growth trajectories correlated with different outcomes. For instance, a faster tempo of pubertal growth correlates with higher bone mineral density, HOMA-IR, fasting insulin, type 2 diabetes, and lung cancer, whereas being taller at early puberty, taller across puberty, and having quicker pubertal growth were associated with higher risk for atrial fibrillation. CONCLUSION: We report novel genetic associations with the tempo of pubertal growth and find that genetic determinants of growth are correlated with reproductive, glycemic, respiratory, and cardiac traits in adulthood. These results aid in identifying specific growth trajectories impacting lifelong health and show that there may not be a single "optimal" pubertal growth pattern.

  @article{RN363,
  abstract = {BACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~ 56,000 trans-ancestry samples with repeated height measurements from age 5 years to adulthood. We performed genetic analysis on six phenotypes representing the magnitude, timing, and intensity of the pubertal growth spurt. To investigate the lifelong impact of genetic variants associated with pubertal growth trajectories, we performed genetic correlation analyses and phenome-wide association studies in the Penn Medicine BioBank and the UK Biobank. RESULTS: Large-scale growth modeling enables an unprecedented view of adolescent growth across contemporary and 20th-century pediatric cohorts. We identify 26 genome-wide significant loci and leverage trans-ancestry data to perform fine-mapping. Our data reveals genetic relationships between pediatric height growth and health across the life course, with different growth trajectories correlated with different outcomes. For instance, a faster tempo of pubertal growth correlates with higher bone mineral density, HOMA-IR, fasting insulin, type 2 diabetes, and lung cancer, whereas being taller at early puberty, taller across puberty, and having quicker pubertal growth were associated with higher risk for atrial fibrillation. CONCLUSION: We report novel genetic associations with the tempo of pubertal growth and find that genetic determinants of growth are correlated with reproductive, glycemic, respiratory, and cardiac traits in adulthood. These results aid in identifying specific growth trajectories impacting lifelong health and show that there may not be a single "optimal" pubertal growth pattern.},
  author = {Bradfield, J. P. and Kember, R. L. and Ulrich, A. and Balkiyarova, Z. and Alyass, A. and Aris, I. M. and Bell, J. A. and Broadaway, K. A. and Chen, Z. and Chai, J. F. and Davies, N. M. and Fernandez-Orth, D. and Bustamante, M. and Fore, R. and Ganguli, A. and Heiskala, A. and Hottenga, J. J. and Íñiguez, C. and Kobes, S. and Leinonen, J. and Lowry, E. and Lyytikainen, L. P. and Mahajan, A. and Pitkänen, N. and Schnurr, T. M. and Have, C. T. and Strachan, D. P. and Thiering, E. and Vogelezang, S. and Wade, K. H. and Wang, C. A. and Wong, A. and Holm, L. A. and Chesi, A. and Choong, C. and Cruz, M. and Elliott, P. and Franks, S. and Frithioff-Bøjsøe, C. and Gauderman, W. J. and Glessner, J. T. and Gilsanz, V. and Griesman, K. and Hanson, R. L. and Kaakinen, M. and Kalkwarf, H. and Kelly, A. and Kindler, J. and Kähönen, M. and Lanca, C. and Lappe, J. and Lee, N. R. and McCormack, S. and Mentch, F. D. and Mitchell, J. A. and Mononen, N. and Niinikoski, H. and Oken, E. and Pahkala, K. and Sim, X. and Teo, Y. Y. and Baier, L. J. and van Beijsterveldt, T. and Adair, L. S. and Boomsma, D. I. and de Geus, E. and Guxens, M. and Eriksson, J. G. and Felix, J. F. and Gilliland, F. D. and Biobank, P. M. and Hansen, T. and Hardy, R. and Hivert, M. F. and Holm, J. C. and Jaddoe, V. W. V. and Järvelin, M. R. and Lehtimäki, T. and Mackey, D. A. and Meyre, D. and Mohlke, K. L. and Mykkänen, J. and Oberfield, S. and Pennell, C. E. and Perry, J. R. B. and Raitakari, O. and Rivadeneira, F. and Saw, S. M. and Sebert, S. and Shepherd, J. A. and Standl, M. and Sørensen, T. I. A. and Timpson, N. J. and Torrent, M. and Willemsen, G. and Hypponen, E. and Power, C. and McCarthy, M. I. and Freathy, R. M. and Widén, E. and others},
  journal = {Genome Biol},
  keywords = {grapp-caib},
  number = 1,
  pages = 22,
  title = {Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes},
  type = {Journal Article},
  volume = 25,
  year = 2024
  }
  

  %0 Journal Article
  %1 RN363
  %A Bradfield, J. P.
  %A Kember, R. L.
  %A Ulrich, A.
  %A Balkiyarova, Z.
  %A Alyass, A.
  %A Aris, I. M.
  %A Bell, J. A.
  %A Broadaway, K. A.
  %A Chen, Z.
  %A Chai, J. F.
  %A Davies, N. M.
  %A Fernandez-Orth, D.
  %A Bustamante, M.
  %A Fore, R.
  %A Ganguli, A.
  %A Heiskala, A.
  %A Hottenga, J. J.
  %A Íñiguez, C.
  %A Kobes, S.
  %A Leinonen, J.
  %A Lowry, E.
  %A Lyytikainen, L. P.
  %A Mahajan, A.
  %A Pitkänen, N.
  %A Schnurr, T. M.
  %A Have, C. T.
  %A Strachan, D. P.
  %A Thiering, E.
  %A Vogelezang, S.
  %A Wade, K. H.
  %A Wang, C. A.
  %A Wong, A.
  %A Holm, L. A.
  %A Chesi, A.
  %A Choong, C.
  %A Cruz, M.
  %A Elliott, P.
  %A Franks, S.
  %A Frithioff-Bøjsøe, C.
  %A Gauderman, W. J.
  %A Glessner, J. T.
  %A Gilsanz, V.
  %A Griesman, K.
  %A Hanson, R. L.
  %A Kaakinen, M.
  %A Kalkwarf, H.
  %A Kelly, A.
  %A Kindler, J.
  %A Kähönen, M.
  %A Lanca, C.
  %A Lappe, J.
  %A Lee, N. R.
  %A McCormack, S.
  %A Mentch, F. D.
  %A Mitchell, J. A.
  %A Mononen, N.
  %A Niinikoski, H.
  %A Oken, E.
  %A Pahkala, K.
  %A Sim, X.
  %A Teo, Y. Y.
  %A Baier, L. J.
  %A van Beijsterveldt, T.
  %A Adair, L. S.
  %A Boomsma, D. I.
  %A de Geus, E.
  %A Guxens, M.
  %A Eriksson, J. G.
  %A Felix, J. F.
  %A Gilliland, F. D.
  %A Biobank, P. M.
  %A Hansen, T.
  %A Hardy, R.
  %A Hivert, M. F.
  %A Holm, J. C.
  %A Jaddoe, V. W. V.
  %A Järvelin, M. R.
  %A Lehtimäki, T.
  %A Mackey, D. A.
  %A Meyre, D.
  %A Mohlke, K. L.
  %A Mykkänen, J.
  %A Oberfield, S.
  %A Pennell, C. E.
  %A Perry, J. R. B.
  %A Raitakari, O.
  %A Rivadeneira, F.
  %A Saw, S. M.
  %A Sebert, S.
  %A Shepherd, J. A.
  %A Standl, M.
  %A Sørensen, T. I. A.
  %A Timpson, N. J.
  %A Torrent, M.
  %A Willemsen, G.
  %A Hypponen, E.
  %A Power, C.
  %A McCarthy, M. I.
  %A Freathy, R. M.
  %A Widén, E.
  %A others,
  %D 2024
  %J Genome Biol
  %N 1
  %P 22
  %R 10.1186/s13059-023-03136-z
  %T Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
  %V 25
  %X BACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~ 56,000 trans-ancestry samples with repeated height measurements from age 5 years to adulthood. We performed genetic analysis on six phenotypes representing the magnitude, timing, and intensity of the pubertal growth spurt. To investigate the lifelong impact of genetic variants associated with pubertal growth trajectories, we performed genetic correlation analyses and phenome-wide association studies in the Penn Medicine BioBank and the UK Biobank. RESULTS: Large-scale growth modeling enables an unprecedented view of adolescent growth across contemporary and 20th-century pediatric cohorts. We identify 26 genome-wide significant loci and leverage trans-ancestry data to perform fine-mapping. Our data reveals genetic relationships between pediatric height growth and health across the life course, with different growth trajectories correlated with different outcomes. For instance, a faster tempo of pubertal growth correlates with higher bone mineral density, HOMA-IR, fasting insulin, type 2 diabetes, and lung cancer, whereas being taller at early puberty, taller across puberty, and having quicker pubertal growth were associated with higher risk for atrial fibrillation. CONCLUSION: We report novel genetic associations with the tempo of pubertal growth and find that genetic determinants of growth are correlated with reproductive, glycemic, respiratory, and cardiac traits in adulthood. These results aid in identifying specific growth trajectories impacting lifelong health and show that there may not be a single "optimal" pubertal growth pattern.
  

• 
  1.

  Zamanillo-Campos R, Fiol-DeRoque MA, Serrano-Ripoll MJ, Llobera J, Taltavull-Aparicio JM, Leiva A, Ripoll-Amengual J, Angullo-Martínez E, Socias I, Masmiquel L, Konieczna J, Zaforteza-Dezcallar M, Boronat-Moreiro MA, Mira-Martínez S, Gervilla-García E, Ricci-Cabello I. Impact of an SMS intervention to support type 2 diabetes self-management: DiabeText clinical trial. The British journal of general practice : the journal of the Royal College of General Practitioners [Internet]. England; 2024 Oct.;:BJGP.2024.0206-. https://pubmed.ncbi.nlm.nih.gov/39362693

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUND: Complications arising from uncontrolled Type 2 Diabetes Mellitus (T2DM) pose a significant burden on individuals' well-being and healthcare resources. Digital interventions may play a key role in mitigating such complications by supporting patients to adequately self-manage their condition. AIM: To assess the impact of DiabeText, a new theory-based, patient-centered, mobile health intervention integrated with electronic health records to send tailored short text messages to support T2DM self-management. DESIGN AND SETTING: Pragmatic, Phase III, 12-month, two-arm randomized clinical trial with T2DM primary care patients in Spain. METHOD: 742 participants with suboptimal glycemic control (HbA1c>7.5) were randomly allocated to a control (usual care) or intervention (DiabeText) group. The DiabeText group received, in addition to usual care, 165 messages focused on healthy lifestyle and medication adherence. PRIMARY OUTCOME: glycated hemoglobin (HbA1c). SECONDARY OUTCOMES: medication possession ratio, quality of life (EQ-5D-5L), diabetes self-efficacy (DSES); and self-reported adherence to medication, Mediterranean diet (MEDAS-14), and physical activity (IPAQ). RESULTS: Over the 12-month period, we observed no significant differences in HbA1c between the intervention and the control groups (Beta=-0.025 (-0.198 to 0.147; p=0.772)). In comparison with the control group, the DiabeText group showed significant (p<0.05) improvements in self-reported medication adherence (OR=1.4; 95%CI: 1.0 to 1.9), DSES (Cohen's d=0.35), and EQ5D-5L (Cohen's d=0.18) scores; but not in the rest of secondary outcomes. CONCLUSION: DiabeText successfully improved quality of life, diabetes self-management, and self-reported medication adherence in primary care patients with T2DM. Further research is needed to enhance its effects on physiological outcomes.

  @article{zamanillocampos2024impact,
  abstract = {BACKGROUND: Complications arising from uncontrolled Type 2 Diabetes Mellitus (T2DM) pose a significant burden on individuals' well-being and healthcare resources. Digital interventions may play a key role in mitigating such complications by supporting patients to adequately self-manage their condition. AIM: To assess the impact of DiabeText, a new theory-based, patient-centered, mobile health intervention integrated with electronic health records to send tailored short text messages to support T2DM self-management. DESIGN AND SETTING: Pragmatic, Phase III, 12-month, two-arm randomized clinical trial with T2DM primary care patients in Spain. METHOD: 742 participants with suboptimal glycemic control (HbA1c>7.5) were randomly allocated to a control (usual care) or intervention (DiabeText) group. The DiabeText group received, in addition to usual care, 165 messages focused on healthy lifestyle and medication adherence. PRIMARY OUTCOME: glycated hemoglobin (HbA1c). SECONDARY OUTCOMES: medication possession ratio, quality of life (EQ-5D-5L), diabetes self-efficacy (DSES); and self-reported adherence to medication, Mediterranean diet (MEDAS-14), and physical activity (IPAQ). RESULTS: Over the 12-month period, we observed no significant differences in HbA1c between the intervention and the control groups (Beta=-0.025 (-0.198 to 0.147; p=0.772)). In comparison with the control group, the DiabeText group showed significant (p<0.05) improvements in self-reported medication adherence (OR=1.4; 95%CI: 1.0 to 1.9), DSES (Cohen's d=0.35), and EQ5D-5L (Cohen's d=0.18) scores; but not in the rest of secondary outcomes. CONCLUSION: DiabeText successfully improved quality of life, diabetes self-management, and self-reported medication adherence in primary care patients with T2DM. Further research is needed to enhance its effects on physiological outcomes.},
  address = {England},
  author = {Zamanillo-Campos, Rocío and Fiol-DeRoque, Maria Antonia and Serrano-Ripoll, Maria Jesús and Llobera, Joan and Taltavull-Aparicio, Joana María and Leiva, Alfonso and Ripoll-Amengual, Joana and Angullo-Martínez, Escarlata and Socias, Isabel and Masmiquel, Luis and Konieczna, Jadwiga and Zaforteza-Dezcallar, María and Boronat-Moreiro, Maria Asunción and Mira-Martínez, Sofía and Gervilla-García, Elena and Ricci-Cabello, Ignacio},
  journal = {The British journal of general practice : the journal of the Royal College of General Practitioners},
  keywords = {evisap grapp-caib},
  month = {oct},
  pages = {BJGP.2024.0206--},
  title = {Impact of an SMS intervention to support type 2 diabetes self-management: DiabeText clinical trial},
  year = 2024
  }
  

  %0 Journal Article
  %1 zamanillocampos2024impact
  %A Zamanillo-Campos, Rocío
  %A Fiol-DeRoque, Maria Antonia
  %A Serrano-Ripoll, Maria Jesús
  %A Llobera, Joan
  %A Taltavull-Aparicio, Joana María
  %A Leiva, Alfonso
  %A Ripoll-Amengual, Joana
  %A Angullo-Martínez, Escarlata
  %A Socias, Isabel
  %A Masmiquel, Luis
  %A Konieczna, Jadwiga
  %A Zaforteza-Dezcallar, María
  %A Boronat-Moreiro, Maria Asunción
  %A Mira-Martínez, Sofía
  %A Gervilla-García, Elena
  %A Ricci-Cabello, Ignacio
  %C England
  %D 2024
  %J The British journal of general practice : the journal of the Royal College of General Practitioners
  %P BJGP.2024.0206--
  %R 10.3399/BJGP.2024.0206
  %T Impact of an SMS intervention to support type 2 diabetes self-management: DiabeText clinical trial
  %U https://pubmed.ncbi.nlm.nih.gov/39362693
  %X BACKGROUND: Complications arising from uncontrolled Type 2 Diabetes Mellitus (T2DM) pose a significant burden on individuals' well-being and healthcare resources. Digital interventions may play a key role in mitigating such complications by supporting patients to adequately self-manage their condition. AIM: To assess the impact of DiabeText, a new theory-based, patient-centered, mobile health intervention integrated with electronic health records to send tailored short text messages to support T2DM self-management. DESIGN AND SETTING: Pragmatic, Phase III, 12-month, two-arm randomized clinical trial with T2DM primary care patients in Spain. METHOD: 742 participants with suboptimal glycemic control (HbA1c>7.5) were randomly allocated to a control (usual care) or intervention (DiabeText) group. The DiabeText group received, in addition to usual care, 165 messages focused on healthy lifestyle and medication adherence. PRIMARY OUTCOME: glycated hemoglobin (HbA1c). SECONDARY OUTCOMES: medication possession ratio, quality of life (EQ-5D-5L), diabetes self-efficacy (DSES); and self-reported adherence to medication, Mediterranean diet (MEDAS-14), and physical activity (IPAQ). RESULTS: Over the 12-month period, we observed no significant differences in HbA1c between the intervention and the control groups (Beta=-0.025 (-0.198 to 0.147; p=0.772)). In comparison with the control group, the DiabeText group showed significant (p<0.05) improvements in self-reported medication adherence (OR=1.4; 95%CI: 1.0 to 1.9), DSES (Cohen's d=0.35), and EQ5D-5L (Cohen's d=0.18) scores; but not in the rest of secondary outcomes. CONCLUSION: DiabeText successfully improved quality of life, diabetes self-management, and self-reported medication adherence in primary care patients with T2DM. Further research is needed to enhance its effects on physiological outcomes.
  

• 
  1.

  Abad-Corpa E, Rich-Ruiz M, Sánchez-López D, Solano Ruiz C, Casado-Ramírez E, Arregui-Gallego B, Moreno-Casbas MT, Muñoz-Jiménez D, Vidal-Thomàs MC, Company-Sancho MC, Orts-Cortés MI. Learning, internalisation and integration of the COVID-19 pandemic in healthcare workers: A qualitative document analysis. Nursing inquiry [Internet]. Australia; 2024 Sep.;:e12673-e12673. https://pubmed.ncbi.nlm.nih.gov/39297396

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  The COVID-19 pandemic triggered an unprecedented health crisis that impacted healthcare systems worldwide. This study explores how Spanish healthcare workers learned, internalised and integrated values and work behaviours during the COVID-19 pandemic and their impact on the personal sphere. This documentary research, using images, narratives and audiovisual content, was framed within the interpretative hermeneutic paradigm. Categories and subcategories emerged after a final theoretical sampling that focused on the analysis. Data triangulation between researchers favoured theoretical saturation. A total of 117 images and 27 texts were selected. The analysis identified three stages: bewilderment, seeking functionality in the chaos and integrating chaos into care. The data reflects how the need for security and knowledge, and the exhaustion and frustration caused by the initial working conditions, prompted adaptive responses. These responses involved focusing on problem-solving and strengthening group sentiments and solidarity. Subsequently, the data indicates the acceptance of new structural, organisational and communication aspects. The findings of the analysis will contribute towards finding a framework that can help understand community health crisis events.

  @article{abadcorpa2024learning,
  abstract = {The COVID-19 pandemic triggered an unprecedented health crisis that impacted healthcare systems worldwide. This study explores how Spanish healthcare workers learned, internalised and integrated values and work behaviours during the COVID-19 pandemic and their impact on the personal sphere. This documentary research, using images, narratives and audiovisual content, was framed within the interpretative hermeneutic paradigm. Categories and subcategories emerged after a final theoretical sampling that focused on the analysis. Data triangulation between researchers favoured theoretical saturation. A total of 117 images and 27 texts were selected. The analysis identified three stages: bewilderment, seeking functionality in the chaos and integrating chaos into care. The data reflects how the need for security and knowledge, and the exhaustion and frustration caused by the initial working conditions, prompted adaptive responses. These responses involved focusing on problem-solving and strengthening group sentiments and solidarity. Subsequently, the data indicates the acceptance of new structural, organisational and communication aspects. The findings of the analysis will contribute towards finding a framework that can help understand community health crisis events.},
  address = {Australia},
  author = {Abad-Corpa, Eva and Rich-Ruiz, Manuel and Sánchez-López, Dolores and Solano Ruiz, Carmen and Casado-Ramírez, Elvira and Arregui-Gallego, Beatriz and Moreno-Casbas, María Teresa and Muñoz-Jiménez, Daniel and Vidal-Thomàs, M Clara and Company-Sancho, M Consuelo and Orts-Cortés, María Isabel},
  journal = {Nursing inquiry},
  keywords = {grapp-caib},
  month = {sep},
  pages = {e12673--e12673},
  title = {Learning, internalisation and integration of the COVID-19 pandemic in healthcare workers: A qualitative document analysis},
  year = 2024
  }
  

  %0 Journal Article
  %1 abadcorpa2024learning
  %A Abad-Corpa, Eva
  %A Rich-Ruiz, Manuel
  %A Sánchez-López, Dolores
  %A Solano Ruiz, Carmen
  %A Casado-Ramírez, Elvira
  %A Arregui-Gallego, Beatriz
  %A Moreno-Casbas, María Teresa
  %A Muñoz-Jiménez, Daniel
  %A Vidal-Thomàs, M Clara
  %A Company-Sancho, M Consuelo
  %A Orts-Cortés, María Isabel
  %C Australia
  %D 2024
  %J Nursing inquiry
  %P e12673--e12673
  %R 10.1111/nin.12673
  %T Learning, internalisation and integration of the COVID-19 pandemic in healthcare workers: A qualitative document analysis
  %U https://pubmed.ncbi.nlm.nih.gov/39297396
  %X The COVID-19 pandemic triggered an unprecedented health crisis that impacted healthcare systems worldwide. This study explores how Spanish healthcare workers learned, internalised and integrated values and work behaviours during the COVID-19 pandemic and their impact on the personal sphere. This documentary research, using images, narratives and audiovisual content, was framed within the interpretative hermeneutic paradigm. Categories and subcategories emerged after a final theoretical sampling that focused on the analysis. Data triangulation between researchers favoured theoretical saturation. A total of 117 images and 27 texts were selected. The analysis identified three stages: bewilderment, seeking functionality in the chaos and integrating chaos into care. The data reflects how the need for security and knowledge, and the exhaustion and frustration caused by the initial working conditions, prompted adaptive responses. These responses involved focusing on problem-solving and strengthening group sentiments and solidarity. Subsequently, the data indicates the acceptance of new structural, organisational and communication aspects. The findings of the analysis will contribute towards finding a framework that can help understand community health crisis events.
  

• 
  1.

  Chela-Alvarez X, Leiva A, Bulilete O, Llobera J. Socioeconomic determinants and self-rated health among hotel housekeepers in the Balearic Islands (Spain). Frontiers in public health [Internet]. Switzerland; 2024 Sep.;12:1390582-. https://pubmed.ncbi.nlm.nih.gov/39286742

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Hotel housekeepers constitute an important occupational group in the Balearic Islands (Spain). Housekeeping is considered low-skilled and precarious and typically involves high physical demands and time pressure. The aim of this study is to analyze the association between the socioeconomic determinants of health and hotel housekeepers' self-rated health. METHODS: This is a cross-sectional study conducted in Primary Health Care in the Balearic Islands (November 2018-February 2019). Hotel housekeepers over 18 years of age with free access to the Balearic Public Health System who had been employed during 2018 were eligible. RESULTS: We enrolled 1,043 hotel housekeepers; the mean score of health perceived status was 72.4/100 (SD 19.0). Those with a lower self-perceived health were statistically significant older, had Spanish nationality, lower level of studies, permanent or recurring seasonal contract, financial difficulties, a higher level of occupational stress, an external locus of control, reported work-life balance difficulties, were former smokers, insufficiently physical active and obese. We found lower scores in self-perceived health status score of -7.159 (CI95% -10.20- -4.12) among hotel housekeepers with osteoarthritis; -6.858 (CI95% -11.89- -1.82) among those with chronic depression; -3.697 (CI95% -6.08- -1.31) among those who reported difficulties in work-life balance; -2.414 (CI95% -4.69- -0.13) among participants who performed insufficient physical activity; -2.107 (CI% -4.44- -0.23) among those who reported financial strain. Lower self-rated health was also associated to a higher perceived stress, -1.440 (CI95% -2.09- -0.79); BMI (kg/m(2)), -0.299 (CI95% -0.53- -0.07); and longer time working as HH -0.177 (CI95% -0.33- -0.03). CONCLUSION: Our results underscore the importance of psychosocial (such as difficulties in work-life balance and occupational stress) and material factors (such as financial difficulties) when explaining differences in self-perceived health. Public health interventions aimed at improving health status must consider inequalities in material and working conditions.

  @article{chelaalvarez2024socioeconomic,
  abstract = {BACKGROUND: Hotel housekeepers constitute an important occupational group in the Balearic Islands (Spain). Housekeeping is considered low-skilled and precarious and typically involves high physical demands and time pressure. The aim of this study is to analyze the association between the socioeconomic determinants of health and hotel housekeepers' self-rated health. METHODS: This is a cross-sectional study conducted in Primary Health Care in the Balearic Islands (November 2018-February 2019). Hotel housekeepers over 18 years of age with free access to the Balearic Public Health System who had been employed during 2018 were eligible. RESULTS: We enrolled 1,043 hotel housekeepers; the mean score of health perceived status was 72.4/100 (SD 19.0). Those with a lower self-perceived health were statistically significant older, had Spanish nationality, lower level of studies, permanent or recurring seasonal contract, financial difficulties, a higher level of occupational stress, an external locus of control, reported work-life balance difficulties, were former smokers, insufficiently physical active and obese. We found lower scores in self-perceived health status score of -7.159 (CI95% -10.20- -4.12) among hotel housekeepers with osteoarthritis; -6.858 (CI95% -11.89- -1.82) among those with chronic depression; -3.697 (CI95% -6.08- -1.31) among those who reported difficulties in work-life balance; -2.414 (CI95% -4.69- -0.13) among participants who performed insufficient physical activity; -2.107 (CI% -4.44- -0.23) among those who reported financial strain. Lower self-rated health was also associated to a higher perceived stress, -1.440 (CI95% -2.09- -0.79); BMI (kg/m(2)), -0.299 (CI95% -0.53- -0.07); and longer time working as HH -0.177 (CI95% -0.33- -0.03). CONCLUSION: Our results underscore the importance of psychosocial (such as difficulties in work-life balance and occupational stress) and material factors (such as financial difficulties) when explaining differences in self-perceived health. Public health interventions aimed at improving health status must consider inequalities in material and working conditions.},
  address = {Switzerland},
  author = {Chela-Alvarez, Xenia and Leiva, Alfonso and Bulilete, Oana and Llobera, Joan},
  journal = {Frontiers in public health},
  keywords = {grapp-caib},
  month = {sep},
  pages = {1390582--1390582},
  title = {Socioeconomic determinants and self-rated health among hotel housekeepers in the Balearic Islands (Spain)},
  volume = 12,
  year = 2024
  }
  

  %0 Journal Article
  %1 chelaalvarez2024socioeconomic
  %A Chela-Alvarez, Xenia
  %A Leiva, Alfonso
  %A Bulilete, Oana
  %A Llobera, Joan
  %C Switzerland
  %D 2024
  %J Frontiers in public health
  %P 1390582--1390582
  %R 10.3389/fpubh.2024.1390582
  %T Socioeconomic determinants and self-rated health among hotel housekeepers in the Balearic Islands (Spain)
  %U https://pubmed.ncbi.nlm.nih.gov/39286742
  %V 12
  %X BACKGROUND: Hotel housekeepers constitute an important occupational group in the Balearic Islands (Spain). Housekeeping is considered low-skilled and precarious and typically involves high physical demands and time pressure. The aim of this study is to analyze the association between the socioeconomic determinants of health and hotel housekeepers' self-rated health. METHODS: This is a cross-sectional study conducted in Primary Health Care in the Balearic Islands (November 2018-February 2019). Hotel housekeepers over 18 years of age with free access to the Balearic Public Health System who had been employed during 2018 were eligible. RESULTS: We enrolled 1,043 hotel housekeepers; the mean score of health perceived status was 72.4/100 (SD 19.0). Those with a lower self-perceived health were statistically significant older, had Spanish nationality, lower level of studies, permanent or recurring seasonal contract, financial difficulties, a higher level of occupational stress, an external locus of control, reported work-life balance difficulties, were former smokers, insufficiently physical active and obese. We found lower scores in self-perceived health status score of -7.159 (CI95% -10.20- -4.12) among hotel housekeepers with osteoarthritis; -6.858 (CI95% -11.89- -1.82) among those with chronic depression; -3.697 (CI95% -6.08- -1.31) among those who reported difficulties in work-life balance; -2.414 (CI95% -4.69- -0.13) among participants who performed insufficient physical activity; -2.107 (CI% -4.44- -0.23) among those who reported financial strain. Lower self-rated health was also associated to a higher perceived stress, -1.440 (CI95% -2.09- -0.79); BMI (kg/m(2)), -0.299 (CI95% -0.53- -0.07); and longer time working as HH -0.177 (CI95% -0.33- -0.03). CONCLUSION: Our results underscore the importance of psychosocial (such as difficulties in work-life balance and occupational stress) and material factors (such as financial difficulties) when explaining differences in self-perceived health. Public health interventions aimed at improving health status must consider inequalities in material and working conditions.
  

• 
  1.

  Fiol deRoque MA, Valderas JM, Arias de la Torre J, Serrano-Ripoll MJ, Gens-Barberà M, Sánchez-Freire E, Martín-Luján FM, Olry de Labry A, Ricci-Cabello I. Evaluation of the psychometric performance of the Spanish and Catalan versions of the patient reported experiences and Outcomes of Safety in Primary Care (PREOS-PC)-Compact questionnaire. The European journal of general practice [Internet]. England; 2024 Dec.;30(1):2296573-. https://pubmed.ncbi.nlm.nih.gov/38197321

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Patients provide a unique, irreplaceable, and essential perspective in evaluating patient safety. The suite of Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) tools are a notable exception to the scarcity of patient-reported patient safety measures. Full evaluation of their performance has only been attempted for the English version, thereby limiting its international applicability. OBJECTIVES: To assess the psychometric performance of the Spanish and Catalan versions of the PREOS-PC-Compact. METHODS: Cross-sectional validation study. We used Classical Test Theory methods to examine scale score distribution, internal consistency, and construct validity; and Item Response Theory (IRT) methods to further explore construct validity. RESULTS: 3287 patients completed the Spanish version, and 1007 the Catalan version. Similar results were obtained for both versions. Confirmatory Factor Analysis supported a single construct for each scale. The correlations between PREOS-PC-Compact scales and known group analysis suggested adequate construct validity (inconclusive for known groups at the provider level). All four multi-item scales demonstrated adequate internal consistency reliability (α > 0.7), which was only confirmed for test-retest reliability for 'Practice activation.' A sample between 60-90 patients per practice was estimated sufficient to produce scores with reliability > 0.7 for all scales except for harm scales. IRT models showed disordered thresholds for 'Practice activation' and 'Harm burden' but showed excellent fit after reducing the response categories. CONCLUSION: The Spanish and Catalan versions of the PREOS-PC-Compact are broadly valid and reliable tools to measure patient safety in Spanish primary care centres; confirmation of lower-than-expected test-rest reliability merits further examination .

  @article{fiolderoque2024evaluation,
  abstract = {BACKGROUND: Patients provide a unique, irreplaceable, and essential perspective in evaluating patient safety. The suite of Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) tools are a notable exception to the scarcity of patient-reported patient safety measures. Full evaluation of their performance has only been attempted for the English version, thereby limiting its international applicability. OBJECTIVES: To assess the psychometric performance of the Spanish and Catalan versions of the PREOS-PC-Compact. METHODS: Cross-sectional validation study. We used Classical Test Theory methods to examine scale score distribution, internal consistency, and construct validity; and Item Response Theory (IRT) methods to further explore construct validity. RESULTS: 3287 patients completed the Spanish version, and 1007 the Catalan version. Similar results were obtained for both versions. Confirmatory Factor Analysis supported a single construct for each scale. The correlations between PREOS-PC-Compact scales and known group analysis suggested adequate construct validity (inconclusive for known groups at the provider level). All four multi-item scales demonstrated adequate internal consistency reliability (α > 0.7), which was only confirmed for test-retest reliability for 'Practice activation.' A sample between 60-90 patients per practice was estimated sufficient to produce scores with reliability > 0.7 for all scales except for harm scales. IRT models showed disordered thresholds for 'Practice activation' and 'Harm burden' but showed excellent fit after reducing the response categories. CONCLUSION: The Spanish and Catalan versions of the PREOS-PC-Compact are broadly valid and reliable tools to measure patient safety in Spanish primary care centres; confirmation of lower-than-expected test-rest reliability merits further examination .},
  address = {England},
  author = {Fiol deRoque, Maria A and Valderas, José M and Arias de la Torre, Jorge and Serrano-Ripoll, Maria J and Gens-Barberà, Montserrat and Sánchez-Freire, Encarna and Martín-Luján, Francisco M and Olry de Labry, Antonio and Ricci-Cabello, Ignacio},
  journal = {The European journal of general practice},
  keywords = {evisap grapp-caib},
  month = {dec},
  number = 1,
  pages = {2296573--2296573},
  title = {Evaluation of the psychometric performance of the Spanish and Catalan versions of the patient reported experiences and Outcomes of Safety in Primary Care (PREOS-PC)-Compact questionnaire},
  volume = 30,
  year = 2024
  }
  

  %0 Journal Article
  %1 fiolderoque2024evaluation
  %A Fiol deRoque, Maria A
  %A Valderas, José M
  %A Arias de la Torre, Jorge
  %A Serrano-Ripoll, Maria J
  %A Gens-Barberà, Montserrat
  %A Sánchez-Freire, Encarna
  %A Martín-Luján, Francisco M
  %A Olry de Labry, Antonio
  %A Ricci-Cabello, Ignacio
  %C England
  %D 2024
  %J The European journal of general practice
  %N 1
  %P 2296573--2296573
  %R 10.1080/13814788.2023.2296573
  %T Evaluation of the psychometric performance of the Spanish and Catalan versions of the patient reported experiences and Outcomes of Safety in Primary Care (PREOS-PC)-Compact questionnaire
  %U https://pubmed.ncbi.nlm.nih.gov/38197321
  %V 30
  %X BACKGROUND: Patients provide a unique, irreplaceable, and essential perspective in evaluating patient safety. The suite of Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) tools are a notable exception to the scarcity of patient-reported patient safety measures. Full evaluation of their performance has only been attempted for the English version, thereby limiting its international applicability. OBJECTIVES: To assess the psychometric performance of the Spanish and Catalan versions of the PREOS-PC-Compact. METHODS: Cross-sectional validation study. We used Classical Test Theory methods to examine scale score distribution, internal consistency, and construct validity; and Item Response Theory (IRT) methods to further explore construct validity. RESULTS: 3287 patients completed the Spanish version, and 1007 the Catalan version. Similar results were obtained for both versions. Confirmatory Factor Analysis supported a single construct for each scale. The correlations between PREOS-PC-Compact scales and known group analysis suggested adequate construct validity (inconclusive for known groups at the provider level). All four multi-item scales demonstrated adequate internal consistency reliability (α > 0.7), which was only confirmed for test-retest reliability for 'Practice activation.' A sample between 60-90 patients per practice was estimated sufficient to produce scores with reliability > 0.7 for all scales except for harm scales. IRT models showed disordered thresholds for 'Practice activation' and 'Harm burden' but showed excellent fit after reducing the response categories. CONCLUSION: The Spanish and Catalan versions of the PREOS-PC-Compact are broadly valid and reliable tools to measure patient safety in Spanish primary care centres; confirmation of lower-than-expected test-rest reliability merits further examination .
  

• 
  1.

  Marina Arroyo M, Ramírez Gallegos I, López-González Ángel A, Vicente-Herrero MT, Vallejos D, Sastre-Alzamora T, Ramírez Manent JI. Usefulness of the ECORE-BF Scale to Determine Atherogenic Risk in 386,924 Spanish Workers. Nutrients [Internet]. Switzerland; 2024 Jul.;16(15):2434-. https://pubmed.ncbi.nlm.nih.gov/39125315

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Cardiovascular diseases are the leading cause of death worldwide. Obesity and atherosclerosis are considered risk factors for this pathology. There are multiple methods to evaluate obesity, in the same way as there are different formulas to determine atherogenic risk. Since both pathologies are closely related, the objective of our work was to evaluate whether the ECORE-BF scale is capable of predicting atherogenic risk. METHODS: Observational, descriptive, and cross-sectional study in which 386,924 workers from several autonomous communities in Spain participated. The association between the ECORE-BF scale and five atherogenic risk indices was evaluated. The relationship between variables was assessed using the chi-square test and Student's t test in independent samples. Multivariate analysis was performed with the multinomial logistic regression test, calculating the odds ratio and 95% confidence intervals, with the Hosmer-Lemeshow goodness-of-fit test. ROC curves established the cut-off points for moderate and high vascular age and determined the Youden index. RESULTS: The mean values of the ECORE-BF scale were higher in individuals with atherogenic dyslipidemia and the lipid triad, as well as in those with elevated values of the three atherogenic indices studied, with p <0.001 in all cases. As atherogenic risk increased across the five evaluated scales, the prevalence of obesity also significantly increased, with p <0.001 in all cases. In the ROC curve analysis, the AUCs for atherogenic dyslipidemia and the lipid triad were above 0.75, indicating a good association between these scales and the ECORE-BF. Although the Youden indices were not exceedingly high, they were around 0.5. CONCLUSIONS: There is a good association between atherogenic risk scales, atherogenic dyslipidemia, and lipid triad, and the ECORE-BF scale. The ECORE-BF scale can be a useful and quick tool to evaluate atherogenic risk in primary care and occupational medicine consultations without the need for blood tests.

  @article{marinaarroyo2024usefulness,
  abstract = {BACKGROUND: Cardiovascular diseases are the leading cause of death worldwide. Obesity and atherosclerosis are considered risk factors for this pathology. There are multiple methods to evaluate obesity, in the same way as there are different formulas to determine atherogenic risk. Since both pathologies are closely related, the objective of our work was to evaluate whether the ECORE-BF scale is capable of predicting atherogenic risk. METHODS: Observational, descriptive, and cross-sectional study in which 386,924 workers from several autonomous communities in Spain participated. The association between the ECORE-BF scale and five atherogenic risk indices was evaluated. The relationship between variables was assessed using the chi-square test and Student's t test in independent samples. Multivariate analysis was performed with the multinomial logistic regression test, calculating the odds ratio and 95% confidence intervals, with the Hosmer-Lemeshow goodness-of-fit test. ROC curves established the cut-off points for moderate and high vascular age and determined the Youden index. RESULTS: The mean values of the ECORE-BF scale were higher in individuals with atherogenic dyslipidemia and the lipid triad, as well as in those with elevated values of the three atherogenic indices studied, with p <0.001 in all cases. As atherogenic risk increased across the five evaluated scales, the prevalence of obesity also significantly increased, with p <0.001 in all cases. In the ROC curve analysis, the AUCs for atherogenic dyslipidemia and the lipid triad were above 0.75, indicating a good association between these scales and the ECORE-BF. Although the Youden indices were not exceedingly high, they were around 0.5. CONCLUSIONS: There is a good association between atherogenic risk scales, atherogenic dyslipidemia, and lipid triad, and the ECORE-BF scale. The ECORE-BF scale can be a useful and quick tool to evaluate atherogenic risk in primary care and occupational medicine consultations without the need for blood tests.},
  address = {Switzerland},
  author = {Marina Arroyo, Marta and Ramírez Gallegos, Ignacio and López-González, Ángel Arturo and Vicente-Herrero, María Teófila and Vallejos, Daniela and Sastre-Alzamora, Tomás and Ramírez Manent, José Ignacio},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {jul},
  number = 15,
  pages = {2434--},
  title = {Usefulness of the ECORE-BF Scale to Determine Atherogenic Risk in 386,924 Spanish Workers},
  volume = 16,
  year = 2024
  }
  

  %0 Journal Article
  %1 marinaarroyo2024usefulness
  %A Marina Arroyo, Marta
  %A Ramírez Gallegos, Ignacio
  %A López-González, Ángel Arturo
  %A Vicente-Herrero, María Teófila
  %A Vallejos, Daniela
  %A Sastre-Alzamora, Tomás
  %A Ramírez Manent, José Ignacio
  %C Switzerland
  %D 2024
  %J Nutrients
  %N 15
  %P 2434--
  %R 10.3390/nu16152434
  %T Usefulness of the ECORE-BF Scale to Determine Atherogenic Risk in 386,924 Spanish Workers
  %U https://pubmed.ncbi.nlm.nih.gov/39125315
  %V 16
  %X BACKGROUND: Cardiovascular diseases are the leading cause of death worldwide. Obesity and atherosclerosis are considered risk factors for this pathology. There are multiple methods to evaluate obesity, in the same way as there are different formulas to determine atherogenic risk. Since both pathologies are closely related, the objective of our work was to evaluate whether the ECORE-BF scale is capable of predicting atherogenic risk. METHODS: Observational, descriptive, and cross-sectional study in which 386,924 workers from several autonomous communities in Spain participated. The association between the ECORE-BF scale and five atherogenic risk indices was evaluated. The relationship between variables was assessed using the chi-square test and Student's t test in independent samples. Multivariate analysis was performed with the multinomial logistic regression test, calculating the odds ratio and 95% confidence intervals, with the Hosmer-Lemeshow goodness-of-fit test. ROC curves established the cut-off points for moderate and high vascular age and determined the Youden index. RESULTS: The mean values of the ECORE-BF scale were higher in individuals with atherogenic dyslipidemia and the lipid triad, as well as in those with elevated values of the three atherogenic indices studied, with p <0.001 in all cases. As atherogenic risk increased across the five evaluated scales, the prevalence of obesity also significantly increased, with p <0.001 in all cases. In the ROC curve analysis, the AUCs for atherogenic dyslipidemia and the lipid triad were above 0.75, indicating a good association between these scales and the ECORE-BF. Although the Youden indices were not exceedingly high, they were around 0.5. CONCLUSIONS: There is a good association between atherogenic risk scales, atherogenic dyslipidemia, and lipid triad, and the ECORE-BF scale. The ECORE-BF scale can be a useful and quick tool to evaluate atherogenic risk in primary care and occupational medicine consultations without the need for blood tests.
  

• 
  1.

  Gordito Soler M, López-González Ángel A, Vallejos D, Martínez-Almoyna Rifá E, Vicente-Herrero MT, Ramírez-Manent JI. Usefulness of Body Fat and Visceral Fat Determined by Bioimpedanciometry versus Body Mass Index and Waist Circumference in Predicting Elevated Values of Different Risk Scales for Non-Alcoholic Fatty Liver Disease. Nutrients [Internet]. Switzerland; 2024 Jul.;16(13):2160-. https://pubmed.ncbi.nlm.nih.gov/38999907

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Obesity constitutes a public health problem worldwide and causes non-alcoholic fatty liver disease (MALFD), the leading cause of liver disease in developed countries, which progresses to liver cirrhosis and liver cancer. MAFLD is associated with obesity and can be evaluated by validated formulas to assess MAFLD risk using different parameters such as the body mass index (BMI) and waist circumference (WC). However, these parameters do not accurately measure body fat. As MAFLD is strongly associated with obesity, we hypothesize that measuring body and visceral fat by electrical bioimpedance is an efficient method to predict the risk of MAFLD. The objective of our work was to demonstrate that electrical bioimpedance is a more efficient method than the BMI or WC to predict an elevated risk of MAFLD. METHODS: A cross-sectional, descriptive study involving 8590 Spanish workers in the Balearic Islands was carried out. The study's sample of employees was drawn from those who underwent occupational medicine examinations between January 2019 and December 2020. Five MAFLD risk scales were determined for evaluating very high levels of body fat and visceral fat. The determination of body and visceral fat was performed using bioimpedanciometry. Student's t-test was employed to ascertain the mean and standard deviation of quantitative data. The chi-square test was used to find prevalences for qualitative variables, while ROC curves were used to define the cut-off points for body and visceral fat. The calculations included the area under the curve (AUC), the cut-off points along with their Youden index, sensitivity, and specificity. Correlation and concordance between the various scales were determined using Pearson's correlation index and Cohen's kappa, respectively. RESULTS: As both total body fat and visceral fat increase, the risk of MAFLD increases with a statistically significant result (p < 0.001), presenting a higher risk in men. The areas under the curve (AUC) of the five scales that assess overweight and obesity to determine the occurrence of high values of the different MAFLD risk scales were very high, most of them exceeding 0.9. These AUC values were higher for visceral and body fat than for the BMI or waist circumference. FLD-high presented the best results in men and women with the AUC at around 0.97, both for visceral fat and total body fat, with a high Youden index in all cases (women body fat = 0.830, visceral fat = 0.892; men body fat = 0.780, visceral fat = 0.881). CONCLUSIONS: In our study, all the overweight and obesity scales show a very good association with the scales assessing the risk of MAFLD. These values are higher for visceral and body fat than for waist circumference and the BMI. Both visceral fat and body fat are better associated than the BMI and waist circumference with MAFLD risk scales.

  @article{gorditosoler2024usefulness,
  abstract = {BACKGROUND: Obesity constitutes a public health problem worldwide and causes non-alcoholic fatty liver disease (MALFD), the leading cause of liver disease in developed countries, which progresses to liver cirrhosis and liver cancer. MAFLD is associated with obesity and can be evaluated by validated formulas to assess MAFLD risk using different parameters such as the body mass index (BMI) and waist circumference (WC). However, these parameters do not accurately measure body fat. As MAFLD is strongly associated with obesity, we hypothesize that measuring body and visceral fat by electrical bioimpedance is an efficient method to predict the risk of MAFLD. The objective of our work was to demonstrate that electrical bioimpedance is a more efficient method than the BMI or WC to predict an elevated risk of MAFLD. METHODS: A cross-sectional, descriptive study involving 8590 Spanish workers in the Balearic Islands was carried out. The study's sample of employees was drawn from those who underwent occupational medicine examinations between January 2019 and December 2020. Five MAFLD risk scales were determined for evaluating very high levels of body fat and visceral fat. The determination of body and visceral fat was performed using bioimpedanciometry. Student's t-test was employed to ascertain the mean and standard deviation of quantitative data. The chi-square test was used to find prevalences for qualitative variables, while ROC curves were used to define the cut-off points for body and visceral fat. The calculations included the area under the curve (AUC), the cut-off points along with their Youden index, sensitivity, and specificity. Correlation and concordance between the various scales were determined using Pearson's correlation index and Cohen's kappa, respectively. RESULTS: As both total body fat and visceral fat increase, the risk of MAFLD increases with a statistically significant result (p < 0.001), presenting a higher risk in men. The areas under the curve (AUC) of the five scales that assess overweight and obesity to determine the occurrence of high values of the different MAFLD risk scales were very high, most of them exceeding 0.9. These AUC values were higher for visceral and body fat than for the BMI or waist circumference. FLD-high presented the best results in men and women with the AUC at around 0.97, both for visceral fat and total body fat, with a high Youden index in all cases (women body fat = 0.830, visceral fat = 0.892; men body fat = 0.780, visceral fat = 0.881). CONCLUSIONS: In our study, all the overweight and obesity scales show a very good association with the scales assessing the risk of MAFLD. These values are higher for visceral and body fat than for waist circumference and the BMI. Both visceral fat and body fat are better associated than the BMI and waist circumference with MAFLD risk scales.},
  address = {Switzerland},
  author = {Gordito Soler, María and López-González, Ángel Arturo and Vallejos, Daniela and Martínez-Almoyna Rifá, Emilio and Vicente-Herrero, María Teófila and Ramírez-Manent, José Ignacio},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {jul},
  number = 13,
  pages = {2160--},
  title = {Usefulness of Body Fat and Visceral Fat Determined by Bioimpedanciometry versus Body Mass Index and Waist Circumference in Predicting Elevated Values of Different Risk Scales for Non-Alcoholic Fatty Liver Disease},
  volume = 16,
  year = 2024
  }
  

  %0 Journal Article
  %1 gorditosoler2024usefulness
  %A Gordito Soler, María
  %A López-González, Ángel Arturo
  %A Vallejos, Daniela
  %A Martínez-Almoyna Rifá, Emilio
  %A Vicente-Herrero, María Teófila
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2024
  %J Nutrients
  %N 13
  %P 2160--
  %R 10.3390/nu16132160
  %T Usefulness of Body Fat and Visceral Fat Determined by Bioimpedanciometry versus Body Mass Index and Waist Circumference in Predicting Elevated Values of Different Risk Scales for Non-Alcoholic Fatty Liver Disease
  %U https://pubmed.ncbi.nlm.nih.gov/38999907
  %V 16
  %X BACKGROUND: Obesity constitutes a public health problem worldwide and causes non-alcoholic fatty liver disease (MALFD), the leading cause of liver disease in developed countries, which progresses to liver cirrhosis and liver cancer. MAFLD is associated with obesity and can be evaluated by validated formulas to assess MAFLD risk using different parameters such as the body mass index (BMI) and waist circumference (WC). However, these parameters do not accurately measure body fat. As MAFLD is strongly associated with obesity, we hypothesize that measuring body and visceral fat by electrical bioimpedance is an efficient method to predict the risk of MAFLD. The objective of our work was to demonstrate that electrical bioimpedance is a more efficient method than the BMI or WC to predict an elevated risk of MAFLD. METHODS: A cross-sectional, descriptive study involving 8590 Spanish workers in the Balearic Islands was carried out. The study's sample of employees was drawn from those who underwent occupational medicine examinations between January 2019 and December 2020. Five MAFLD risk scales were determined for evaluating very high levels of body fat and visceral fat. The determination of body and visceral fat was performed using bioimpedanciometry. Student's t-test was employed to ascertain the mean and standard deviation of quantitative data. The chi-square test was used to find prevalences for qualitative variables, while ROC curves were used to define the cut-off points for body and visceral fat. The calculations included the area under the curve (AUC), the cut-off points along with their Youden index, sensitivity, and specificity. Correlation and concordance between the various scales were determined using Pearson's correlation index and Cohen's kappa, respectively. RESULTS: As both total body fat and visceral fat increase, the risk of MAFLD increases with a statistically significant result (p < 0.001), presenting a higher risk in men. The areas under the curve (AUC) of the five scales that assess overweight and obesity to determine the occurrence of high values of the different MAFLD risk scales were very high, most of them exceeding 0.9. These AUC values were higher for visceral and body fat than for the BMI or waist circumference. FLD-high presented the best results in men and women with the AUC at around 0.97, both for visceral fat and total body fat, with a high Youden index in all cases (women body fat = 0.830, visceral fat = 0.892; men body fat = 0.780, visceral fat = 0.881). CONCLUSIONS: In our study, all the overweight and obesity scales show a very good association with the scales assessing the risk of MAFLD. These values are higher for visceral and body fat than for waist circumference and the BMI. Both visceral fat and body fat are better associated than the BMI and waist circumference with MAFLD risk scales.
  

• 
  1.

  Cortés-Aguilar R, Malih N, Abbate M, Fresneda S, Yañez A, Bennasar-Veny M. Validity of nutrition screening tools for risk of malnutrition among hospitalized adult patients: A systematic review and meta-analysis. Clinical nutrition (Edinburgh, Scotland) [Internet]. England; 2024 Mar.;43(5):1094-116. https://pubmed.ncbi.nlm.nih.gov/38582013

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUNDS & AIMS: Malnutrition is prevalent among hospitalized patients in developed countries, contributing to negative health outcomes and increased healthcare costs. Timely identification and management of malnutrition are crucial. The lack of a universally accepted definition and standardized diagnostic criteria for malnutrition has led to the development of various screening tools, each with varying validity. This complicates early identification of malnutrition, hindering effective intervention strategies. This systematic review and meta-analysis aimed to identify the most valid and reliable nutritional screening tool for assessing the risk of malnutrition in hospitalized adults. METHODS: A systematic literature search was conducted to identify validation studies published from inception to November 2023, in the Pubmed/MEDLINE, Embase, and CINAHL databases. This systematic review was registered in INPLASY (INPLASY202090028). The risk of bias and quality of included studies were assessed using the Quality Assessment of Diagnostic Accuracy Studies version 2 (QUADAS-2). Meta-analyses were performed for screening tools accuracy using the symmetric hierarchical summary receiver operative characteristics models. RESULTS: Of the 1646 articles retrieved, 60 met the inclusion criteria and were included in the systematic review, and 21 were included in the meta-analysis. A total of 51 malnutrition risk screening tools and 9 reference standards were identified. The meta-analyses assessed four common malnutrition risk screening tools against two reference standards (Subjective Global Assessment [SGA] and European Society for Clinical Nutrition and Metabolism [ESPEN] criteria). The Malnutrition Universal Screening Tool (MUST) vs SGA had a sensitivity (95% Confidence Interval) of 0.84 (0.73-0.91), and specificity of 0.85 (0.75-0.91). The MUST vs ESPEN had a sensitivity of 0.97 (0.53-0.99) and specificity of 0.80 (0.50-0.94). The Malnutrition Screening Tool (MST) vs SGA had a sensitivity of 0.81 (0.67-0.90) and specificity of 0.79 (0.72-0.74). The Mini Nutritional Assessment-Short Form (MNA-SF) vs ESPEN had a sensitivity of 0.99 (0.41-0.99) and specificity of 0.60 (0.45-0.73). The Nutrition Universal Screening Tool-2002 (NRS-2002) vs SGA had a sensitivity of 0.76 (0.58-0.87) and specificity of 0.86 (0.76-0.93). CONCLUSIONS: The MUST demonstrated high accuracy in detecting malnutrition risk in hospitalized adults. However, the quality of the studies included varied greatly, possibly introducing bias in the results. Future research should compare tools within a specific patient population using a valid and universal gold standard to ensure improved patient care and outcomes.

  @article{cortesaguilar2024validity,
  abstract = {BACKGROUNDS & AIMS: Malnutrition is prevalent among hospitalized patients in developed countries, contributing to negative health outcomes and increased healthcare costs. Timely identification and management of malnutrition are crucial. The lack of a universally accepted definition and standardized diagnostic criteria for malnutrition has led to the development of various screening tools, each with varying validity. This complicates early identification of malnutrition, hindering effective intervention strategies. This systematic review and meta-analysis aimed to identify the most valid and reliable nutritional screening tool for assessing the risk of malnutrition in hospitalized adults. METHODS: A systematic literature search was conducted to identify validation studies published from inception to November 2023, in the Pubmed/MEDLINE, Embase, and CINAHL databases. This systematic review was registered in INPLASY (INPLASY202090028). The risk of bias and quality of included studies were assessed using the Quality Assessment of Diagnostic Accuracy Studies version 2 (QUADAS-2). Meta-analyses were performed for screening tools accuracy using the symmetric hierarchical summary receiver operative characteristics models. RESULTS: Of the 1646 articles retrieved, 60 met the inclusion criteria and were included in the systematic review, and 21 were included in the meta-analysis. A total of 51 malnutrition risk screening tools and 9 reference standards were identified. The meta-analyses assessed four common malnutrition risk screening tools against two reference standards (Subjective Global Assessment [SGA] and European Society for Clinical Nutrition and Metabolism [ESPEN] criteria). The Malnutrition Universal Screening Tool (MUST) vs SGA had a sensitivity (95% Confidence Interval) of 0.84 (0.73-0.91), and specificity of 0.85 (0.75-0.91). The MUST vs ESPEN had a sensitivity of 0.97 (0.53-0.99) and specificity of 0.80 (0.50-0.94). The Malnutrition Screening Tool (MST) vs SGA had a sensitivity of 0.81 (0.67-0.90) and specificity of 0.79 (0.72-0.74). The Mini Nutritional Assessment-Short Form (MNA-SF) vs ESPEN had a sensitivity of 0.99 (0.41-0.99) and specificity of 0.60 (0.45-0.73). The Nutrition Universal Screening Tool-2002 (NRS-2002) vs SGA had a sensitivity of 0.76 (0.58-0.87) and specificity of 0.86 (0.76-0.93). CONCLUSIONS: The MUST demonstrated high accuracy in detecting malnutrition risk in hospitalized adults. However, the quality of the studies included varied greatly, possibly introducing bias in the results. Future research should compare tools within a specific patient population using a valid and universal gold standard to ensure improved patient care and outcomes.},
  address = {England},
  author = {Cortés-Aguilar, Regina and Malih, Narges and Abbate, Manuela and Fresneda, Sergio and Yañez, Aina and Bennasar-Veny, Miquel},
  journal = {Clinical nutrition (Edinburgh, Scotland)},
  keywords = {evisap grapp-caib},
  month = {mar},
  number = 5,
  pages = {1094--1116},
  title = {Validity of nutrition screening tools for risk of malnutrition among hospitalized adult patients: A systematic review and meta-analysis},
  volume = 43,
  year = 2024
  }
  

  %0 Journal Article
  %1 cortesaguilar2024validity
  %A Cortés-Aguilar, Regina
  %A Malih, Narges
  %A Abbate, Manuela
  %A Fresneda, Sergio
  %A Yañez, Aina
  %A Bennasar-Veny, Miquel
  %C England
  %D 2024
  %J Clinical nutrition (Edinburgh, Scotland)
  %N 5
  %P 1094--1116
  %R 10.1016/j.clnu.2024.03.008
  %T Validity of nutrition screening tools for risk of malnutrition among hospitalized adult patients: A systematic review and meta-analysis
  %U https://pubmed.ncbi.nlm.nih.gov/38582013
  %V 43
  %X BACKGROUNDS & AIMS: Malnutrition is prevalent among hospitalized patients in developed countries, contributing to negative health outcomes and increased healthcare costs. Timely identification and management of malnutrition are crucial. The lack of a universally accepted definition and standardized diagnostic criteria for malnutrition has led to the development of various screening tools, each with varying validity. This complicates early identification of malnutrition, hindering effective intervention strategies. This systematic review and meta-analysis aimed to identify the most valid and reliable nutritional screening tool for assessing the risk of malnutrition in hospitalized adults. METHODS: A systematic literature search was conducted to identify validation studies published from inception to November 2023, in the Pubmed/MEDLINE, Embase, and CINAHL databases. This systematic review was registered in INPLASY (INPLASY202090028). The risk of bias and quality of included studies were assessed using the Quality Assessment of Diagnostic Accuracy Studies version 2 (QUADAS-2). Meta-analyses were performed for screening tools accuracy using the symmetric hierarchical summary receiver operative characteristics models. RESULTS: Of the 1646 articles retrieved, 60 met the inclusion criteria and were included in the systematic review, and 21 were included in the meta-analysis. A total of 51 malnutrition risk screening tools and 9 reference standards were identified. The meta-analyses assessed four common malnutrition risk screening tools against two reference standards (Subjective Global Assessment [SGA] and European Society for Clinical Nutrition and Metabolism [ESPEN] criteria). The Malnutrition Universal Screening Tool (MUST) vs SGA had a sensitivity (95% Confidence Interval) of 0.84 (0.73-0.91), and specificity of 0.85 (0.75-0.91). The MUST vs ESPEN had a sensitivity of 0.97 (0.53-0.99) and specificity of 0.80 (0.50-0.94). The Malnutrition Screening Tool (MST) vs SGA had a sensitivity of 0.81 (0.67-0.90) and specificity of 0.79 (0.72-0.74). The Mini Nutritional Assessment-Short Form (MNA-SF) vs ESPEN had a sensitivity of 0.99 (0.41-0.99) and specificity of 0.60 (0.45-0.73). The Nutrition Universal Screening Tool-2002 (NRS-2002) vs SGA had a sensitivity of 0.76 (0.58-0.87) and specificity of 0.86 (0.76-0.93). CONCLUSIONS: The MUST demonstrated high accuracy in detecting malnutrition risk in hospitalized adults. However, the quality of the studies included varied greatly, possibly introducing bias in the results. Future research should compare tools within a specific patient population using a valid and universal gold standard to ensure improved patient care and outcomes.
  

• 
  1.

  Agache I, Ricci-Cabello I, Canelo-Aybar C, Annesi-Maesano I, Cecchi L, Biagioni B, Chung KF, D’Amato G, Damialis A, Del Giacco S, De Las Vecillas L, Dominguez-Ortega J, Galán C, Gilles S, Giovannini M, Holgate S, Jeebhay M, Nadeau K, Papadopoulos N, Quirce S, Sastre J, Traidl-Hoffmann C, Walusiak-Skorupa J, Salazar J, Sousa-Pinto B, Colom M, Fiol deRoque MA, Gorreto López L, Malih N, Moro L, Pardo MG, Pazo PG, Campos RZ, Saletti-Cuesta L, Akdis M, Alonso-Coello P, Jutel M, Akdis CA. The impact of exposure to tobacco smoke and e-cigarettes on asthma-related outcomes: Systematic review informing the EAACI guidelines on environmental science for allergic diseases and asthma. Allergy [Internet]. Denmark; 2024 May;:10.1111/all.16151-. https://pubmed.ncbi.nlm.nih.gov/38783343

  AbstractURLBibTeXEndNoteDOIBibSonomy

  To inform the clinical practice guidelines' recommendations developed by the European Academy of Allergy and Clinical Immunology systematic reviews (SR) assessed using GRADE on the impact of environmental tobacco smoke (ETS) and active smoking on the risk of new-onset asthma/recurrent wheezing (RW)/low lung function (LF), and on asthma-related outcomes. Only longitudinal studies were included, almost all on combustion cigarettes, only one assessing e-cigarettes and LF. According to the first SR (67 studies), prenatal ETS increases the risk of RW (moderate certainty evidence) and may increase the risk of new-onset asthma and of low LF (low certainty evidence). Postnatal ETS increases the risk of new-onset asthma and of RW (moderate certainty evidence) and may impact LF (low certainty evidence). Combined in utero and postnatal ETS may increase the risk of new-onset asthma (low certainty evidence) and increases the risk of RW (moderate certainty evidence). According to the second SR (24 studies), ETS increases the risk of severe asthma exacerbations and impairs asthma control and LF (moderate certainty evidence). According to the third SR (25 studies), active smoking increases the risk of severe asthma exacerbations and of suboptimal asthma control (moderate certainty evidence) and may impact asthma-related quality-of-life and LF (low certainty evidence).

  @article{agache2024impact,
  abstract = {To inform the clinical practice guidelines' recommendations developed by the European Academy of Allergy and Clinical Immunology systematic reviews (SR) assessed using GRADE on the impact of environmental tobacco smoke (ETS) and active smoking on the risk of new-onset asthma/recurrent wheezing (RW)/low lung function (LF), and on asthma-related outcomes. Only longitudinal studies were included, almost all on combustion cigarettes, only one assessing e-cigarettes and LF. According to the first SR (67 studies), prenatal ETS increases the risk of RW (moderate certainty evidence) and may increase the risk of new-onset asthma and of low LF (low certainty evidence). Postnatal ETS increases the risk of new-onset asthma and of RW (moderate certainty evidence) and may impact LF (low certainty evidence). Combined in utero and postnatal ETS may increase the risk of new-onset asthma (low certainty evidence) and increases the risk of RW (moderate certainty evidence). According to the second SR (24 studies), ETS increases the risk of severe asthma exacerbations and impairs asthma control and LF (moderate certainty evidence). According to the third SR (25 studies), active smoking increases the risk of severe asthma exacerbations and of suboptimal asthma control (moderate certainty evidence) and may impact asthma-related quality-of-life and LF (low certainty evidence).},
  address = {Denmark},
  author = {Agache, Ioana and Ricci-Cabello, Ignacio and Canelo-Aybar, Carlos and Annesi-Maesano, Isabella and Cecchi, Lorenzo and Biagioni, Benedetta and Chung, Kian Fan and D'Amato, Gennaro and Damialis, Athanasios and Del Giacco, Stefano and De Las Vecillas, Leticia and Dominguez-Ortega, Javier and Galán, Carmen and Gilles, Stefanie and Giovannini, Matteo and Holgate, Stephen and Jeebhay, Mohamed and Nadeau, Kari and Papadopoulos, Nikolaos and Quirce, Santiago and Sastre, Joaquin and Traidl-Hoffmann, Claudia and Walusiak-Skorupa, Jolanta and Salazar, Josefina and Sousa-Pinto, Bernardo and Colom, Miquel and Fiol deRoque, Maria A and Gorreto López, Lucía and Malih, Narges and Moro, Laura and Pardo, Marina García and Pazo, Patricia García and Campos, Rocío Zamanillo and Saletti-Cuesta, L and Akdis, Mubeccel and Alonso-Coello, Pablo and Jutel, Marek and Akdis, Cezmi A},
  journal = {Allergy},
  keywords = {evisap grapp-caib},
  month = {may},
  pages = {10.1111/all.16151--},
  title = {The impact of exposure to tobacco smoke and e-cigarettes on asthma-related outcomes: Systematic review informing the EAACI guidelines on environmental science for allergic diseases and asthma},
  year = 2024
  }
  

  %0 Journal Article
  %1 agache2024impact
  %A Agache, Ioana
  %A Ricci-Cabello, Ignacio
  %A Canelo-Aybar, Carlos
  %A Annesi-Maesano, Isabella
  %A Cecchi, Lorenzo
  %A Biagioni, Benedetta
  %A Chung, Kian Fan
  %A D'Amato, Gennaro
  %A Damialis, Athanasios
  %A Del Giacco, Stefano
  %A De Las Vecillas, Leticia
  %A Dominguez-Ortega, Javier
  %A Galán, Carmen
  %A Gilles, Stefanie
  %A Giovannini, Matteo
  %A Holgate, Stephen
  %A Jeebhay, Mohamed
  %A Nadeau, Kari
  %A Papadopoulos, Nikolaos
  %A Quirce, Santiago
  %A Sastre, Joaquin
  %A Traidl-Hoffmann, Claudia
  %A Walusiak-Skorupa, Jolanta
  %A Salazar, Josefina
  %A Sousa-Pinto, Bernardo
  %A Colom, Miquel
  %A Fiol deRoque, Maria A
  %A Gorreto López, Lucía
  %A Malih, Narges
  %A Moro, Laura
  %A Pardo, Marina García
  %A Pazo, Patricia García
  %A Campos, Rocío Zamanillo
  %A Saletti-Cuesta, L
  %A Akdis, Mubeccel
  %A Alonso-Coello, Pablo
  %A Jutel, Marek
  %A Akdis, Cezmi A
  %C Denmark
  %D 2024
  %J Allergy
  %P 10.1111/all.16151--
  %R 10.1111/all.16151
  %T The impact of exposure to tobacco smoke and e-cigarettes on asthma-related outcomes: Systematic review informing the EAACI guidelines on environmental science for allergic diseases and asthma
  %U https://pubmed.ncbi.nlm.nih.gov/38783343
  %X To inform the clinical practice guidelines' recommendations developed by the European Academy of Allergy and Clinical Immunology systematic reviews (SR) assessed using GRADE on the impact of environmental tobacco smoke (ETS) and active smoking on the risk of new-onset asthma/recurrent wheezing (RW)/low lung function (LF), and on asthma-related outcomes. Only longitudinal studies were included, almost all on combustion cigarettes, only one assessing e-cigarettes and LF. According to the first SR (67 studies), prenatal ETS increases the risk of RW (moderate certainty evidence) and may increase the risk of new-onset asthma and of low LF (low certainty evidence). Postnatal ETS increases the risk of new-onset asthma and of RW (moderate certainty evidence) and may impact LF (low certainty evidence). Combined in utero and postnatal ETS may increase the risk of new-onset asthma (low certainty evidence) and increases the risk of RW (moderate certainty evidence). According to the second SR (24 studies), ETS increases the risk of severe asthma exacerbations and impairs asthma control and LF (moderate certainty evidence). According to the third SR (25 studies), active smoking increases the risk of severe asthma exacerbations and of suboptimal asthma control (moderate certainty evidence) and may impact asthma-related quality-of-life and LF (low certainty evidence).
  

• 
  1.

  Babić A, Barcot O, Visković T, Šarić F, Kirkovski A, Barun I, Križanac Z, Ananda RA, Fuentes Barreiro YV, Malih N, Dimcea DA-M, Ordulj J, Weerasekara I, Spezia M, Žuljević MF, Šuto J, Tancredi L, Pijuk A, Sammali S, Iascone V, von Groote T, Poklepović Peričić T, Puljak L. Frequency of use and adequacy of Cochrane risk of bias tool 2 in non-Cochrane systematic reviews published in 2020: Meta-research study. Research synthesis methods [Internet]. England; 2024 Jan.;:10.1002/jrsm.1695-. https://pubmed.ncbi.nlm.nih.gov/38262609

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Risk of bias (RoB) assessment is essential to the systematic review methodology. The new version of the Cochrane RoB tool for randomized trials (RoB 2) was published in 2019 to address limitations identified since the first version of the tool was published in 2008 and to increase the reliability of assessments. This study analyzed the frequency of usage of the RoB 2 and the adequacy of reporting the RoB 2 assessments in non-Cochrane reviews published in 2020. This meta-research study included non-Cochrane systematic reviews of interventions published in 2020. For the reviews that used the RoB 2 tool, we analyzed the reporting of the RoB 2 assessment. Among 3880 included reviews, the Cochrane RoB 1 tool was the most frequently used (N = 2228; 57.4%), followed by the Cochrane RoB 2 tool (N = 267; 6.9%). From 267 reviews that reported using the RoB 2 tool, 213 (79.8%) actually used it. In 26 (12.2%) reviews, erroneous statements were used to indicate the RoB 2 assessment. Only 20 (9.4%) reviews presented a complete RoB 2 assessment with a detailed table of answers to all signaling questions. The judgment of risk of bias by the RoB 2 tool was not justified by a comment in 158 (74.2%) reviews. Only in 33 (14.5%) of reviews the judgment in all domains was justified in the accompanying comment. In most reviews (81.7%), the RoB was inadequately assessed at the study level. In conclusion, the majority of non-Cochrane reviews published in 2020 still used the Cochrane RoB 1 tool. Many reviews used the RoB 2 tool inadequately. Further studies about the uptake and the use of the RoB 2 tool are needed.

  @article{babic2024frequency,
  abstract = {Risk of bias (RoB) assessment is essential to the systematic review methodology. The new version of the Cochrane RoB tool for randomized trials (RoB 2) was published in 2019 to address limitations identified since the first version of the tool was published in 2008 and to increase the reliability of assessments. This study analyzed the frequency of usage of the RoB 2 and the adequacy of reporting the RoB 2 assessments in non-Cochrane reviews published in 2020. This meta-research study included non-Cochrane systematic reviews of interventions published in 2020. For the reviews that used the RoB 2 tool, we analyzed the reporting of the RoB 2 assessment. Among 3880 included reviews, the Cochrane RoB 1 tool was the most frequently used (N = 2228; 57.4%), followed by the Cochrane RoB 2 tool (N = 267; 6.9%). From 267 reviews that reported using the RoB 2 tool, 213 (79.8%) actually used it. In 26 (12.2%) reviews, erroneous statements were used to indicate the RoB 2 assessment. Only 20 (9.4%) reviews presented a complete RoB 2 assessment with a detailed table of answers to all signaling questions. The judgment of risk of bias by the RoB 2 tool was not justified by a comment in 158 (74.2%) reviews. Only in 33 (14.5%) of reviews the judgment in all domains was justified in the accompanying comment. In most reviews (81.7%), the RoB was inadequately assessed at the study level. In conclusion, the majority of non-Cochrane reviews published in 2020 still used the Cochrane RoB 1 tool. Many reviews used the RoB 2 tool inadequately. Further studies about the uptake and the use of the RoB 2 tool are needed.},
  address = {England},
  author = {Babić, Andrija and Barcot, Ognjen and Visković, Tomislav and Šarić, Frano and Kirkovski, Aleksandar and Barun, Ivana and Križanac, Zvonimir and Ananda, Roshan Arjun and Fuentes Barreiro, Yuli Viviana and Malih, Narges and Dimcea, Daiana Anne-Marie and Ordulj, Josipa and Weerasekara, Ishanka and Spezia, Matteo and Žuljević, Marija Franka and Šuto, Jelena and Tancredi, Luca and Pijuk, Anđela and Sammali, Susanna and Iascone, Veronica and von Groote, Thilo and Poklepović Peričić, Tina and Puljak, Livia},
  journal = {Research synthesis methods},
  keywords = {evisap grapp-caib},
  month = {jan},
  pages = {10.1002/jrsm.1695--},
  title = {Frequency of use and adequacy of Cochrane risk of bias tool 2 in non-Cochrane systematic reviews published in 2020: Meta-research study},
  year = 2024
  }
  

  %0 Journal Article
  %1 babic2024frequency
  %A Babić, Andrija
  %A Barcot, Ognjen
  %A Visković, Tomislav
  %A Šarić, Frano
  %A Kirkovski, Aleksandar
  %A Barun, Ivana
  %A Križanac, Zvonimir
  %A Ananda, Roshan Arjun
  %A Fuentes Barreiro, Yuli Viviana
  %A Malih, Narges
  %A Dimcea, Daiana Anne-Marie
  %A Ordulj, Josipa
  %A Weerasekara, Ishanka
  %A Spezia, Matteo
  %A Žuljević, Marija Franka
  %A Šuto, Jelena
  %A Tancredi, Luca
  %A Pijuk, Anđela
  %A Sammali, Susanna
  %A Iascone, Veronica
  %A von Groote, Thilo
  %A Poklepović Peričić, Tina
  %A Puljak, Livia
  %C England
  %D 2024
  %J Research synthesis methods
  %P 10.1002/jrsm.1695--
  %R 10.1002/jrsm.1695
  %T Frequency of use and adequacy of Cochrane risk of bias tool 2 in non-Cochrane systematic reviews published in 2020: Meta-research study
  %U https://pubmed.ncbi.nlm.nih.gov/38262609
  %X Risk of bias (RoB) assessment is essential to the systematic review methodology. The new version of the Cochrane RoB tool for randomized trials (RoB 2) was published in 2019 to address limitations identified since the first version of the tool was published in 2008 and to increase the reliability of assessments. This study analyzed the frequency of usage of the RoB 2 and the adequacy of reporting the RoB 2 assessments in non-Cochrane reviews published in 2020. This meta-research study included non-Cochrane systematic reviews of interventions published in 2020. For the reviews that used the RoB 2 tool, we analyzed the reporting of the RoB 2 assessment. Among 3880 included reviews, the Cochrane RoB 1 tool was the most frequently used (N = 2228; 57.4%), followed by the Cochrane RoB 2 tool (N = 267; 6.9%). From 267 reviews that reported using the RoB 2 tool, 213 (79.8%) actually used it. In 26 (12.2%) reviews, erroneous statements were used to indicate the RoB 2 assessment. Only 20 (9.4%) reviews presented a complete RoB 2 assessment with a detailed table of answers to all signaling questions. The judgment of risk of bias by the RoB 2 tool was not justified by a comment in 158 (74.2%) reviews. Only in 33 (14.5%) of reviews the judgment in all domains was justified in the accompanying comment. In most reviews (81.7%), the RoB was inadequately assessed at the study level. In conclusion, the majority of non-Cochrane reviews published in 2020 still used the Cochrane RoB 1 tool. Many reviews used the RoB 2 tool inadequately. Further studies about the uptake and the use of the RoB 2 tool are needed.
  

• 
  1.

  Young-Silva Y, Berenguera A, Juvinyà-Canal D, Martí-Lluch R, Arroyo-Uriarte P, Tamayo-Morales O, Marcilla-Toribio I, Elizondo-Alzola U, Méndez-López F, Chela-Àlvarez X, Motrico E. Exploring personal aptitudes and personality traits that, together with social determinants, shape health behaviors and conduct: a thematic analysis based on the Capability, Opportunity, Motivation and Behavior (COM-B) change system. Frontiers in public health [Internet]. Switzerland; 2024 Jun.;12:1387528-. https://pubmed.ncbi.nlm.nih.gov/38898892

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: Effective implementation of strategies to promote health and prevent noncommunicable illnesses requires a profound understanding of the interaction between the individual and society. This study brings to health research the consideration of psychosocial factors that influence the maintenance and change of health behaviors and conduct. From a primary care perspective, it is crucial to propose a biopsychosocial approach for the development of health promotion and self-care programs that embrace personal aptitudes as a relevant individual aspect. OBJECTIVES: To explore experiences related to personal aptitudes and personality traits that influence health behaviors and conduct, taking into account the social determinants of health, through a thematic analysis based on the capability-opportunity-motivation and behavior (COM-B) system. METHODS AND ANALYSIS: This qualitative research is carried out from a descriptive phenomenological perspective, based on 17 focus groups in which 156 people participated. Inductive and deductive analysis techniques were used following Lincoln and Guba's criteria of methodological rigor. In addition to 7 different triangulations of analysts, 6 main categories were identified based on the COM-B system: psychological capacity, physical capacity, physical opportunity, social opportunity, reflective motivation, and automatic motivation. The importance of considering these factors to promote healthy behaviors was stressed. DISCUSSION: This study examined how personal experiences related personal aptitudes and personality traits influence health behaviors and conduct in Spain. It was found that personality traits such as health literacy, self-efficacy, activation, and self-determination can influence the adoption of healthy behaviors. Likewise, the need for control, overthinking, and ambivalence made it impossible. Furthermore, social determinants of health and interpersonal relationships also play an important role. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04386135. Registered on April 30, 2020.

  @article{youngsilva2024exploring,
  abstract = {INTRODUCTION: Effective implementation of strategies to promote health and prevent noncommunicable illnesses requires a profound understanding of the interaction between the individual and society. This study brings to health research the consideration of psychosocial factors that influence the maintenance and change of health behaviors and conduct. From a primary care perspective, it is crucial to propose a biopsychosocial approach for the development of health promotion and self-care programs that embrace personal aptitudes as a relevant individual aspect. OBJECTIVES: To explore experiences related to personal aptitudes and personality traits that influence health behaviors and conduct, taking into account the social determinants of health, through a thematic analysis based on the capability-opportunity-motivation and behavior (COM-B) system. METHODS AND ANALYSIS: This qualitative research is carried out from a descriptive phenomenological perspective, based on 17 focus groups in which 156 people participated. Inductive and deductive analysis techniques were used following Lincoln and Guba's criteria of methodological rigor. In addition to 7 different triangulations of analysts, 6 main categories were identified based on the COM-B system: psychological capacity, physical capacity, physical opportunity, social opportunity, reflective motivation, and automatic motivation. The importance of considering these factors to promote healthy behaviors was stressed. DISCUSSION: This study examined how personal experiences related personal aptitudes and personality traits influence health behaviors and conduct in Spain. It was found that personality traits such as health literacy, self-efficacy, activation, and self-determination can influence the adoption of healthy behaviors. Likewise, the need for control, overthinking, and ambivalence made it impossible. Furthermore, social determinants of health and interpersonal relationships also play an important role. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04386135. Registered on April 30, 2020.},
  address = {Switzerland},
  author = {Young-Silva, Yudy and Berenguera, Anna and Juvinyà-Canal, Dolors and Martí-Lluch, Ruth and Arroyo-Uriarte, Paula and Tamayo-Morales, Olaya and Marcilla-Toribio, Irene and Elizondo-Alzola, Usue and Méndez-López, Fátima and Chela-Àlvarez, Xènia and Motrico, Emma},
  journal = {Frontiers in public health},
  keywords = {grapp-caib},
  month = {jun},
  pages = {1387528--1387528},
  title = {Exploring personal aptitudes and personality traits that, together with social determinants, shape health behaviors and conduct: a thematic analysis based on the Capability, Opportunity, Motivation and Behavior (COM-B) change system},
  volume = 12,
  year = 2024
  }
  

  %0 Journal Article
  %1 youngsilva2024exploring
  %A Young-Silva, Yudy
  %A Berenguera, Anna
  %A Juvinyà-Canal, Dolors
  %A Martí-Lluch, Ruth
  %A Arroyo-Uriarte, Paula
  %A Tamayo-Morales, Olaya
  %A Marcilla-Toribio, Irene
  %A Elizondo-Alzola, Usue
  %A Méndez-López, Fátima
  %A Chela-Àlvarez, Xènia
  %A Motrico, Emma
  %C Switzerland
  %D 2024
  %J Frontiers in public health
  %P 1387528--1387528
  %R 10.3389/fpubh.2024.1387528
  %T Exploring personal aptitudes and personality traits that, together with social determinants, shape health behaviors and conduct: a thematic analysis based on the Capability, Opportunity, Motivation and Behavior (COM-B) change system
  %U https://pubmed.ncbi.nlm.nih.gov/38898892
  %V 12
  %X INTRODUCTION: Effective implementation of strategies to promote health and prevent noncommunicable illnesses requires a profound understanding of the interaction between the individual and society. This study brings to health research the consideration of psychosocial factors that influence the maintenance and change of health behaviors and conduct. From a primary care perspective, it is crucial to propose a biopsychosocial approach for the development of health promotion and self-care programs that embrace personal aptitudes as a relevant individual aspect. OBJECTIVES: To explore experiences related to personal aptitudes and personality traits that influence health behaviors and conduct, taking into account the social determinants of health, through a thematic analysis based on the capability-opportunity-motivation and behavior (COM-B) system. METHODS AND ANALYSIS: This qualitative research is carried out from a descriptive phenomenological perspective, based on 17 focus groups in which 156 people participated. Inductive and deductive analysis techniques were used following Lincoln and Guba's criteria of methodological rigor. In addition to 7 different triangulations of analysts, 6 main categories were identified based on the COM-B system: psychological capacity, physical capacity, physical opportunity, social opportunity, reflective motivation, and automatic motivation. The importance of considering these factors to promote healthy behaviors was stressed. DISCUSSION: This study examined how personal experiences related personal aptitudes and personality traits influence health behaviors and conduct in Spain. It was found that personality traits such as health literacy, self-efficacy, activation, and self-determination can influence the adoption of healthy behaviors. Likewise, the need for control, overthinking, and ambivalence made it impossible. Furthermore, social determinants of health and interpersonal relationships also play an important role. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04386135. Registered on April 30, 2020.
  

• 
  1.

  Fiol deRoque MA, Serrano-Ripoll MJ, Mira-Martínez S, Pastor-Moreno G, Sitges C, García-Buades ME, Gervilla E, Garcia-Toro M, Zamanillo-Campos R, Ricci-Cabello I. Process evaluation of PsyCovidApp, a digital tool for mobile devices aimed at protecting the mental health of healthcare professionals during the COVID-19 pandemic: a mixed method study. Frontiers in psychology [Internet]. Switzerland; 2024 Mar.;15:1378372-. https://pubmed.ncbi.nlm.nih.gov/38577118

  AbstractURLBibTeXEndNoteDOIBibSonomy

  INTRODUCTION: PsyCovidApp, a digital intervention aimed at safeguarding the mental health of healthcare workers during the COVID-19 pandemic, demonstrated in a randomized clinical trial to yield significant improvements solely among healthcare workers undergoing psychotherapy or receiving psychotropic medication. OBJECTIVES: (1) To identify contextual factors and mechanisms of action that influenced the impact of PsyCovidApp during the aforementioned trial; (2) To pinpoint enhancements for optimizing its efficacy. MATERIALS AND METHODS: For the first objective, a process evaluation was conducted, amalgamating quantitative techniques (surveying 216 healthcare professionals who had utilized PsyCovidApp during the trial) and qualitative methods (in-depth interviews with 16 healthcare workers). The second objective involved a panel of seven experts, utilizing the RAND-UCLA methodology. RESULTS: The quantitative study (response rate = 40%) revealed that 22% of respondents had not fully accessed the content of PsyCovidApp. The average usage time was 22.7 min/day, being higher (p < 0.05) among consumers of psychotropic medications. Contents related to relaxation and mindfulness were most highly rated. Acceptability and usefulness scores ranged between 7.3-7.5/10 points, with higher ratings (p < 0.05) among women and older healthcare workers. The qualitative study uncovered that the primary barriers to using PsyCovidApp were workload, lack of time, and exhaustion. Its primary mechanisms of action included emotion identification, mental health regulation (e.g., insomnia, intense emotions), and learning of techniques and skills. The expert panel reached a consensus on 29 proposals to optimize PsyCovidApp. CONCLUSION: The knowledge derived from this study could inform the design and implementation of future similar digital tools.

  @article{fiolderoque2024process,
  abstract = {INTRODUCTION: PsyCovidApp, a digital intervention aimed at safeguarding the mental health of healthcare workers during the COVID-19 pandemic, demonstrated in a randomized clinical trial to yield significant improvements solely among healthcare workers undergoing psychotherapy or receiving psychotropic medication. OBJECTIVES: (1) To identify contextual factors and mechanisms of action that influenced the impact of PsyCovidApp during the aforementioned trial; (2) To pinpoint enhancements for optimizing its efficacy. MATERIALS AND METHODS: For the first objective, a process evaluation was conducted, amalgamating quantitative techniques (surveying 216 healthcare professionals who had utilized PsyCovidApp during the trial) and qualitative methods (in-depth interviews with 16 healthcare workers). The second objective involved a panel of seven experts, utilizing the RAND-UCLA methodology. RESULTS: The quantitative study (response rate = 40%) revealed that 22% of respondents had not fully accessed the content of PsyCovidApp. The average usage time was 22.7 min/day, being higher (p < 0.05) among consumers of psychotropic medications. Contents related to relaxation and mindfulness were most highly rated. Acceptability and usefulness scores ranged between 7.3-7.5/10 points, with higher ratings (p < 0.05) among women and older healthcare workers. The qualitative study uncovered that the primary barriers to using PsyCovidApp were workload, lack of time, and exhaustion. Its primary mechanisms of action included emotion identification, mental health regulation (e.g., insomnia, intense emotions), and learning of techniques and skills. The expert panel reached a consensus on 29 proposals to optimize PsyCovidApp. CONCLUSION: The knowledge derived from this study could inform the design and implementation of future similar digital tools.},
  address = {Switzerland},
  author = {Fiol deRoque, Maria A and Serrano-Ripoll, Maria J and Mira-Martínez, Sofia and Pastor-Moreno, Guadalupe and Sitges, Carolina and García-Buades, M Esther and Gervilla, Elena and Garcia-Toro, Mauro and Zamanillo-Campos, Rocío and Ricci-Cabello, Ignacio},
  journal = {Frontiers in psychology},
  keywords = {evisap grapp-caib},
  month = {mar},
  pages = {1378372--1378372},
  title = {Process evaluation of PsyCovidApp, a digital tool for mobile devices aimed at protecting the mental health of healthcare professionals during the COVID-19 pandemic: a mixed method study},
  volume = 15,
  year = 2024
  }
  

  %0 Journal Article
  %1 fiolderoque2024process
  %A Fiol deRoque, Maria A
  %A Serrano-Ripoll, Maria J
  %A Mira-Martínez, Sofia
  %A Pastor-Moreno, Guadalupe
  %A Sitges, Carolina
  %A García-Buades, M Esther
  %A Gervilla, Elena
  %A Garcia-Toro, Mauro
  %A Zamanillo-Campos, Rocío
  %A Ricci-Cabello, Ignacio
  %C Switzerland
  %D 2024
  %J Frontiers in psychology
  %P 1378372--1378372
  %R 10.3389/fpsyg.2024.1378372
  %T Process evaluation of PsyCovidApp, a digital tool for mobile devices aimed at protecting the mental health of healthcare professionals during the COVID-19 pandemic: a mixed method study
  %U https://pubmed.ncbi.nlm.nih.gov/38577118
  %V 15
  %X INTRODUCTION: PsyCovidApp, a digital intervention aimed at safeguarding the mental health of healthcare workers during the COVID-19 pandemic, demonstrated in a randomized clinical trial to yield significant improvements solely among healthcare workers undergoing psychotherapy or receiving psychotropic medication. OBJECTIVES: (1) To identify contextual factors and mechanisms of action that influenced the impact of PsyCovidApp during the aforementioned trial; (2) To pinpoint enhancements for optimizing its efficacy. MATERIALS AND METHODS: For the first objective, a process evaluation was conducted, amalgamating quantitative techniques (surveying 216 healthcare professionals who had utilized PsyCovidApp during the trial) and qualitative methods (in-depth interviews with 16 healthcare workers). The second objective involved a panel of seven experts, utilizing the RAND-UCLA methodology. RESULTS: The quantitative study (response rate = 40%) revealed that 22% of respondents had not fully accessed the content of PsyCovidApp. The average usage time was 22.7 min/day, being higher (p < 0.05) among consumers of psychotropic medications. Contents related to relaxation and mindfulness were most highly rated. Acceptability and usefulness scores ranged between 7.3-7.5/10 points, with higher ratings (p < 0.05) among women and older healthcare workers. The qualitative study uncovered that the primary barriers to using PsyCovidApp were workload, lack of time, and exhaustion. Its primary mechanisms of action included emotion identification, mental health regulation (e.g., insomnia, intense emotions), and learning of techniques and skills. The expert panel reached a consensus on 29 proposals to optimize PsyCovidApp. CONCLUSION: The knowledge derived from this study could inform the design and implementation of future similar digital tools.
  

• 
  1.

  León-Salas B, Bilbao-González A, de Pascual Y Medina AM, Esteva M, Toledo-Chávarri A, Fuentes-Sánchez C, Bohn-Sarmiento U, Padrón-Peña P, González-Sánchez S, Valcárcel-López R, Trujillo-Martín MDM. Cross-cultural adaptation, reliability and validity of the Spanish version of the long-term quality of life questionnaire. Frontiers in oncology [Internet]. Switzerland; 2024 Mar.;14:1375125-. https://pubmed.ncbi.nlm.nih.gov/38567161

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  PURPOSE: The aim of this study was to translate, culturally adapt, and evaluate the psychometric properties of the Spanish Long-Term Quality of Life (LTQL) questionnaire. METHODS: The LTQL was initially translated into Spanish and cross-culturally adapted based on established guidelines. The Spanish LTQL was administered to patients with breast cancer who had completed their initial treatment 5 years earlier, along with other self-report measures: Quality of Life in Adult Cancer Survivors (QLACS), Hospital Anxiety and Depression Scale (HADS) and EORT-QLQ-BR23. Reliability was evaluated using internal consistency and test-retest. Convergent and known-groups validity were examined. Structural validity as determined by confirmatory factor analysis (CFA) and Rasch analyses was used to assess the unidimensionality and item-functioning of the LTQL domains. RESULTS: Cronbach's alpha were above 0.7 in all domains. Test-retest coefficients were between 0.72 to 0.96 for LTQL domains. LTQL total score was correlated with others total scores of other measures: QLACS (r=-0.39), HADS depression (r=-0.57), HADS anxiety (-0.45) and EORTC-QLQ-BR23 (r=-0.50). CFA provided satisfactory fit indices, with RMSEA value of 0.077 and TLI and CFI values of 0.901 and 0.909, respectively. All factor loadings were higher than 0.40 and statistically significant (P<0.001). Rasch analysis showed that Somatic Concerns domain had 4 misfitting items, and Philosophical/Spiritual View of Life and social Support domains only 1 misfit item. However, unidimensionality was supported for the four domains. CONCLUSION: The findings support the validity and reliability of the Spanish version of LTQL questionnaire to be used in long-term cancer female survivors.

  @article{leonsalas2024crosscultural,
  abstract = {PURPOSE: The aim of this study was to translate, culturally adapt, and evaluate the psychometric properties of the Spanish Long-Term Quality of Life (LTQL) questionnaire. METHODS: The LTQL was initially translated into Spanish and cross-culturally adapted based on established guidelines. The Spanish LTQL was administered to patients with breast cancer who had completed their initial treatment 5 years earlier, along with other self-report measures: Quality of Life in Adult Cancer Survivors (QLACS), Hospital Anxiety and Depression Scale (HADS) and EORT-QLQ-BR23. Reliability was evaluated using internal consistency and test-retest. Convergent and known-groups validity were examined. Structural validity as determined by confirmatory factor analysis (CFA) and Rasch analyses was used to assess the unidimensionality and item-functioning of the LTQL domains. RESULTS: Cronbach's alpha were above 0.7 in all domains. Test-retest coefficients were between 0.72 to 0.96 for LTQL domains. LTQL total score was correlated with others total scores of other measures: QLACS (r=-0.39), HADS depression (r=-0.57), HADS anxiety (-0.45) and EORTC-QLQ-BR23 (r=-0.50). CFA provided satisfactory fit indices, with RMSEA value of 0.077 and TLI and CFI values of 0.901 and 0.909, respectively. All factor loadings were higher than 0.40 and statistically significant (P<0.001). Rasch analysis showed that Somatic Concerns domain had 4 misfitting items, and Philosophical/Spiritual View of Life and social Support domains only 1 misfit item. However, unidimensionality was supported for the four domains. CONCLUSION: The findings support the validity and reliability of the Spanish version of LTQL questionnaire to be used in long-term cancer female survivors.},
  address = {Switzerland},
  author = {León-Salas, Beatriz and Bilbao-González, Amaia and de Pascual Y Medina, Ana María and Esteva, Magdalena and Toledo-Chávarri, Ana and Fuentes-Sánchez, Claudio and Bohn-Sarmiento, Uriel and Padrón-Peña, Pilar and González-Sánchez, Sonia and Valcárcel-López, Rafael and Trujillo-Martín, María Del Mar},
  journal = {Frontiers in oncology},
  keywords = {grapp-caib},
  month = {mar},
  pages = {1375125--1375125},
  title = {Cross-cultural adaptation, reliability and validity of the Spanish version of the long-term quality of life questionnaire},
  volume = 14,
  year = 2024
  }
  

  %0 Journal Article
  %1 leonsalas2024crosscultural
  %A León-Salas, Beatriz
  %A Bilbao-González, Amaia
  %A de Pascual Y Medina, Ana María
  %A Esteva, Magdalena
  %A Toledo-Chávarri, Ana
  %A Fuentes-Sánchez, Claudio
  %A Bohn-Sarmiento, Uriel
  %A Padrón-Peña, Pilar
  %A González-Sánchez, Sonia
  %A Valcárcel-López, Rafael
  %A Trujillo-Martín, María Del Mar
  %C Switzerland
  %D 2024
  %J Frontiers in oncology
  %P 1375125--1375125
  %R 10.3389/fonc.2024.1375125
  %T Cross-cultural adaptation, reliability and validity of the Spanish version of the long-term quality of life questionnaire
  %U https://pubmed.ncbi.nlm.nih.gov/38567161
  %V 14
  %X PURPOSE: The aim of this study was to translate, culturally adapt, and evaluate the psychometric properties of the Spanish Long-Term Quality of Life (LTQL) questionnaire. METHODS: The LTQL was initially translated into Spanish and cross-culturally adapted based on established guidelines. The Spanish LTQL was administered to patients with breast cancer who had completed their initial treatment 5 years earlier, along with other self-report measures: Quality of Life in Adult Cancer Survivors (QLACS), Hospital Anxiety and Depression Scale (HADS) and EORT-QLQ-BR23. Reliability was evaluated using internal consistency and test-retest. Convergent and known-groups validity were examined. Structural validity as determined by confirmatory factor analysis (CFA) and Rasch analyses was used to assess the unidimensionality and item-functioning of the LTQL domains. RESULTS: Cronbach's alpha were above 0.7 in all domains. Test-retest coefficients were between 0.72 to 0.96 for LTQL domains. LTQL total score was correlated with others total scores of other measures: QLACS (r=-0.39), HADS depression (r=-0.57), HADS anxiety (-0.45) and EORTC-QLQ-BR23 (r=-0.50). CFA provided satisfactory fit indices, with RMSEA value of 0.077 and TLI and CFI values of 0.901 and 0.909, respectively. All factor loadings were higher than 0.40 and statistically significant (P<0.001). Rasch analysis showed that Somatic Concerns domain had 4 misfitting items, and Philosophical/Spiritual View of Life and social Support domains only 1 misfit item. However, unidimensionality was supported for the four domains. CONCLUSION: The findings support the validity and reliability of the Spanish version of LTQL questionnaire to be used in long-term cancer female survivors.
  

• 
  1.

  Ramírez Gallegos I, Marina Arroyo M, López-González Ángel A, Vicente-Herrero MT, Vallejos D, Sastre-Alzamora T, Ramírez-Manent JI. The Effect of a Program to Improve Adherence to the Mediterranean Diet on Cardiometabolic Parameters in 7034 Spanish Workers. Nutrients [Internet]. Switzerland; 2024 Apr.;16(7):1082-. https://pubmed.ncbi.nlm.nih.gov/38613115

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Cardiovascular and metabolic diseases include a large group of pathologies and constitute one of the most serious chronic health problems facing the 21st century, with high rates of morbidity and mortality worldwide. Unhealthy diets influence the development of these pathologies. The Mediterranean diet can be an important part in the treatment of these diseases. The objective of this study was to assess the effect of a program that aims to increase adherence to the Mediterranean diet on the improvement of different cardiometabolic risk parameters. METHODS: A prospective intervention study was carried out on 7034 Spanish workers. Prior to the intervention, 22 cardiometabolic risk scales were evaluated. Participants in this study were informed both orally and in writing of the characteristics and benefits of the Mediterranean diet and were given the website of the Ministry of Health, Consumption and Social Welfare of Spain, which provides advice on nutrition. Adherence to the Mediterranean diet was reinforced by sending a monthly SMS to their mobile phones. After six months of follow-up, the 22 risk scales were re-evaluated to assess changes. Means and standard deviations were calculated using Student's t test to analyse quantitative variables. Prevalence was calculated using the Chi-square test when the variables were qualitative. RESULTS: All the cardiometabolic risk scales studied decreased after implementing a program to improve and enhance adherence to the Mediterranean diet. The number of losses in the sample was very low, standing at 4.31%. CONCLUSIONS: The Mediterranean diet is effective in reducing all cardiovascular risk scales evaluated. The mean values and prevalence of high values of the different cardiometabolic risk scales analysed led to lower values after the implementation of the program to increase adherence to the Mediterranean diet. We observed a significant positive difference in metabolic age in both sexes. We have obtained a significant improvement in the insulin resistance index, especially in the SPISE-IR index, data that we have not found in previous publications. Easy access to the Internet and new information and communication technologies facilitate adherence to a diet and can reduce the number of losses.

  @article{ramirezgallegos2024effect,
  abstract = {BACKGROUND: Cardiovascular and metabolic diseases include a large group of pathologies and constitute one of the most serious chronic health problems facing the 21st century, with high rates of morbidity and mortality worldwide. Unhealthy diets influence the development of these pathologies. The Mediterranean diet can be an important part in the treatment of these diseases. The objective of this study was to assess the effect of a program that aims to increase adherence to the Mediterranean diet on the improvement of different cardiometabolic risk parameters. METHODS: A prospective intervention study was carried out on 7034 Spanish workers. Prior to the intervention, 22 cardiometabolic risk scales were evaluated. Participants in this study were informed both orally and in writing of the characteristics and benefits of the Mediterranean diet and were given the website of the Ministry of Health, Consumption and Social Welfare of Spain, which provides advice on nutrition. Adherence to the Mediterranean diet was reinforced by sending a monthly SMS to their mobile phones. After six months of follow-up, the 22 risk scales were re-evaluated to assess changes. Means and standard deviations were calculated using Student's t test to analyse quantitative variables. Prevalence was calculated using the Chi-square test when the variables were qualitative. RESULTS: All the cardiometabolic risk scales studied decreased after implementing a program to improve and enhance adherence to the Mediterranean diet. The number of losses in the sample was very low, standing at 4.31%. CONCLUSIONS: The Mediterranean diet is effective in reducing all cardiovascular risk scales evaluated. The mean values and prevalence of high values of the different cardiometabolic risk scales analysed led to lower values after the implementation of the program to increase adherence to the Mediterranean diet. We observed a significant positive difference in metabolic age in both sexes. We have obtained a significant improvement in the insulin resistance index, especially in the SPISE-IR index, data that we have not found in previous publications. Easy access to the Internet and new information and communication technologies facilitate adherence to a diet and can reduce the number of losses.},
  address = {Switzerland},
  author = {Ramírez Gallegos, Ignacio and Marina Arroyo, Marta and López-González, Ángel Arturo and Vicente-Herrero, Maria Teófila and Vallejos, Daniela and Sastre-Alzamora, Tomás and Ramírez-Manent, José Ignacio},
  journal = {Nutrients},
  keywords = {grapp-caib},
  month = {apr},
  number = 7,
  pages = {1082--},
  title = {The Effect of a Program to Improve Adherence to the Mediterranean Diet on Cardiometabolic Parameters in 7034 Spanish Workers},
  volume = 16,
  year = 2024
  }
  

  %0 Journal Article
  %1 ramirezgallegos2024effect
  %A Ramírez Gallegos, Ignacio
  %A Marina Arroyo, Marta
  %A López-González, Ángel Arturo
  %A Vicente-Herrero, Maria Teófila
  %A Vallejos, Daniela
  %A Sastre-Alzamora, Tomás
  %A Ramírez-Manent, José Ignacio
  %C Switzerland
  %D 2024
  %J Nutrients
  %N 7
  %P 1082--
  %R 10.3390/nu16071082
  %T The Effect of a Program to Improve Adherence to the Mediterranean Diet on Cardiometabolic Parameters in 7034 Spanish Workers
  %U https://pubmed.ncbi.nlm.nih.gov/38613115
  %V 16
  %X BACKGROUND: Cardiovascular and metabolic diseases include a large group of pathologies and constitute one of the most serious chronic health problems facing the 21st century, with high rates of morbidity and mortality worldwide. Unhealthy diets influence the development of these pathologies. The Mediterranean diet can be an important part in the treatment of these diseases. The objective of this study was to assess the effect of a program that aims to increase adherence to the Mediterranean diet on the improvement of different cardiometabolic risk parameters. METHODS: A prospective intervention study was carried out on 7034 Spanish workers. Prior to the intervention, 22 cardiometabolic risk scales were evaluated. Participants in this study were informed both orally and in writing of the characteristics and benefits of the Mediterranean diet and were given the website of the Ministry of Health, Consumption and Social Welfare of Spain, which provides advice on nutrition. Adherence to the Mediterranean diet was reinforced by sending a monthly SMS to their mobile phones. After six months of follow-up, the 22 risk scales were re-evaluated to assess changes. Means and standard deviations were calculated using Student's t test to analyse quantitative variables. Prevalence was calculated using the Chi-square test when the variables were qualitative. RESULTS: All the cardiometabolic risk scales studied decreased after implementing a program to improve and enhance adherence to the Mediterranean diet. The number of losses in the sample was very low, standing at 4.31%. CONCLUSIONS: The Mediterranean diet is effective in reducing all cardiovascular risk scales evaluated. The mean values and prevalence of high values of the different cardiometabolic risk scales analysed led to lower values after the implementation of the program to increase adherence to the Mediterranean diet. We observed a significant positive difference in metabolic age in both sexes. We have obtained a significant improvement in the insulin resistance index, especially in the SPISE-IR index, data that we have not found in previous publications. Easy access to the Internet and new information and communication technologies facilitate adherence to a diet and can reduce the number of losses.
  

• 
  1.

  Abbate M, Parvanova A, López-González Ángel A, Yañez AM, Bennasar-Veny M, Ramírez-Manent JI, Reseghetti E, Ruggenenti P. MAFLD and glomerular hyperfiltration in subjects with normoglycemia, prediabetes and type 2 diabetes: A cross-sectional population study. Diabetes/metabolism research and reviews [Internet]. England; 2024 May;40(4):e3810-e3810. https://pubmed.ncbi.nlm.nih.gov/38757431

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD, 2020 diagnostic criteria) and glomerular hyperfiltration share common risk factors, including obesity, insulin resistance, impaired glucose tolerance, diabetes, dyslipidemia, and hypertension. AIMS: To assess the prevalence of MAFLD and its association with glomerular hyperfiltration and age-related worsening of kidney function in subjects with normoglycemia, prediabetes and type 2 diabetes mellitus (T2DM). METHODS: We analysed data recorded during occupational health visits of 125,070 Spanish civil servants aged 18-65 years with a de-indexed glomerular filtration rate (GFR) estimated with the chronic-kidney-disease-epidemiological (CKD-EPI) equation (estimated glomerular filtration rate [eGFR]) ≥60 mL/min. Subjects were categorised according to fasting plasma glucose levels <100 mg/dL (normoglycemia), ≥100 and ≤ 125 mg/dL (prediabetes), or ≥126 mg/dL and/or antidiabetic treatment (T2DM). The association between MAFLD and glomerular hyperfiltration, defined as a de-indexed eGFR above the age- and gender-specific 95th percentile, was assessed by multivariable logistic regression. RESULTS: In the whole study group, MAFLD prevalence averaged 19.3%. The prevalence progressively increased from 14.7% to 33.2% and to 48.9% in subjects with normoglycemia, prediabetes and T2DM, respectively (p < 0.001 for trend). Adjusted odds ratio (95% CI) for the association between MAFLD and hyperfiltration was 9.06 (8.53-9.62) in the study group considered as a whole, and 8.60 (8.03-9.21), 9.52 (8.11-11.18) and 8.31 (6.70-10.30) in subjects with normoglycemia, prediabetes and T2DM considered separately. In stratified analyses, MAFLD amplified age-dependent eGFR decline in all groups (p < 0.001). CONCLUSIONS: MAFLD prevalence increases across the glycaemic spectrum. MAFLD is significantly associated with hyperfiltration and amplifies the age-related eGFR decline.

  @article{abbate2024mafld,
  abstract = {BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD, 2020 diagnostic criteria) and glomerular hyperfiltration share common risk factors, including obesity, insulin resistance, impaired glucose tolerance, diabetes, dyslipidemia, and hypertension. AIMS: To assess the prevalence of MAFLD and its association with glomerular hyperfiltration and age-related worsening of kidney function in subjects with normoglycemia, prediabetes and type 2 diabetes mellitus (T2DM). METHODS: We analysed data recorded during occupational health visits of 125,070 Spanish civil servants aged 18-65 years with a de-indexed glomerular filtration rate (GFR) estimated with the chronic-kidney-disease-epidemiological (CKD-EPI) equation (estimated glomerular filtration rate [eGFR]) ≥60 mL/min. Subjects were categorised according to fasting plasma glucose levels <100 mg/dL (normoglycemia), ≥100 and ≤ 125 mg/dL (prediabetes), or ≥126 mg/dL and/or antidiabetic treatment (T2DM). The association between MAFLD and glomerular hyperfiltration, defined as a de-indexed eGFR above the age- and gender-specific 95th percentile, was assessed by multivariable logistic regression. RESULTS: In the whole study group, MAFLD prevalence averaged 19.3%. The prevalence progressively increased from 14.7% to 33.2% and to 48.9% in subjects with normoglycemia, prediabetes and T2DM, respectively (p < 0.001 for trend). Adjusted odds ratio (95% CI) for the association between MAFLD and hyperfiltration was 9.06 (8.53-9.62) in the study group considered as a whole, and 8.60 (8.03-9.21), 9.52 (8.11-11.18) and 8.31 (6.70-10.30) in subjects with normoglycemia, prediabetes and T2DM considered separately. In stratified analyses, MAFLD amplified age-dependent eGFR decline in all groups (p < 0.001). CONCLUSIONS: MAFLD prevalence increases across the glycaemic spectrum. MAFLD is significantly associated with hyperfiltration and amplifies the age-related eGFR decline.},
  address = {England},
  author = {Abbate, Manuela and Parvanova, Aneliya and López-González, Ángel Arturo and Yañez, Aina M and Bennasar-Veny, Miquel and Ramírez-Manent, José Ignacio and Reseghetti, Elia and Ruggenenti, Piero},
  journal = {Diabetes/metabolism research and reviews},
  keywords = {grapp-caib},
  month = {may},
  number = 4,
  pages = {e3810--e3810},
  title = {MAFLD and glomerular hyperfiltration in subjects with normoglycemia, prediabetes and type 2 diabetes: A cross-sectional population study},
  volume = 40,
  year = 2024
  }
  

  %0 Journal Article
  %1 abbate2024mafld
  %A Abbate, Manuela
  %A Parvanova, Aneliya
  %A López-González, Ángel Arturo
  %A Yañez, Aina M
  %A Bennasar-Veny, Miquel
  %A Ramírez-Manent, José Ignacio
  %A Reseghetti, Elia
  %A Ruggenenti, Piero
  %C England
  %D 2024
  %J Diabetes/metabolism research and reviews
  %N 4
  %P e3810--e3810
  %R 10.1002/dmrr.3810
  %T MAFLD and glomerular hyperfiltration in subjects with normoglycemia, prediabetes and type 2 diabetes: A cross-sectional population study
  %U https://pubmed.ncbi.nlm.nih.gov/38757431
  %V 40
  %X BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD, 2020 diagnostic criteria) and glomerular hyperfiltration share common risk factors, including obesity, insulin resistance, impaired glucose tolerance, diabetes, dyslipidemia, and hypertension. AIMS: To assess the prevalence of MAFLD and its association with glomerular hyperfiltration and age-related worsening of kidney function in subjects with normoglycemia, prediabetes and type 2 diabetes mellitus (T2DM). METHODS: We analysed data recorded during occupational health visits of 125,070 Spanish civil servants aged 18-65 years with a de-indexed glomerular filtration rate (GFR) estimated with the chronic-kidney-disease-epidemiological (CKD-EPI) equation (estimated glomerular filtration rate [eGFR]) ≥60 mL/min. Subjects were categorised according to fasting plasma glucose levels <100 mg/dL (normoglycemia), ≥100 and ≤ 125 mg/dL (prediabetes), or ≥126 mg/dL and/or antidiabetic treatment (T2DM). The association between MAFLD and glomerular hyperfiltration, defined as a de-indexed eGFR above the age- and gender-specific 95th percentile, was assessed by multivariable logistic regression. RESULTS: In the whole study group, MAFLD prevalence averaged 19.3%. The prevalence progressively increased from 14.7% to 33.2% and to 48.9% in subjects with normoglycemia, prediabetes and T2DM, respectively (p < 0.001 for trend). Adjusted odds ratio (95% CI) for the association between MAFLD and hyperfiltration was 9.06 (8.53-9.62) in the study group considered as a whole, and 8.60 (8.03-9.21), 9.52 (8.11-11.18) and 8.31 (6.70-10.30) in subjects with normoglycemia, prediabetes and T2DM considered separately. In stratified analyses, MAFLD amplified age-dependent eGFR decline in all groups (p < 0.001). CONCLUSIONS: MAFLD prevalence increases across the glycaemic spectrum. MAFLD is significantly associated with hyperfiltration and amplifies the age-related eGFR decline.
  

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  1.

  Malih N, Konieczna J, Fernandez MN, Fiol deRoque MA, Zamanillo-Campos R, Ricci-Cabello I. Preparatory work for the safety evaluation by EFSA of Human-identical Milk Oligosaccharides as Novel Foods. EFSA Supporting Publications [Internet]. 2024;21:8955E. https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/sp.efsa.2024.EN-8955

  AbstractURLBibTeXEndNoteBibSonomy

  Abstract Background and aims This report describes a scoping literature review as preparatory work for the safety evaluation by EFSA of Human-identical Milk Oligosaccharides (HiMOs) as Novel Foods (NFs). The main objective was to gather information on the concentrations of Human Milk Oligosaccharides (HMOs) in human milk, both individual and total, and the combinations/mixtures of HiMOs/HMOs in commercially available products or those reported in the literature. Methods A scoping literature review was conducted, including a search strategy implemented in biomedical (PubMed) and multidisciplinary (Web of Science) databases from 2013 to March 2024, supplemented by an ad hoc search for primary studies included in two key recent systematic reviews and grey literature searches on relevant food business operators' websites. Both primary and secondary studies were selected to determine the individual concentrations of target HMOs, the total concentration of HMOs and relevant HMO fractions, and the combinations/mixtures of HiMOs/HMOs. Only studies with full text published in English or Spanish were eligible, excluding patents, editorials, conference abstracts, books, and dissertations. Results The structured searches yielded 2,851 unique references, with 218 selected for full-text evaluation and 36 additional unique references from the key systematic reviews. Ultimately, 171 publications were included in the review. Fourteen companies related to HiMOs were identified through grey literature. In most publications, concentration data for multiple groups of donors (e.g., based on factors like secretor status or lactation period) were reported. By groups of donors, the mean total concentration of HMOs in milk (excluding colostrum) was 6,740 mg/L, whereas the mean by publication was 5,341 mg/L. By publication, the mean concentrations of individual HMOs (mg/L, excluding colostrum) were: LNnT 288, LNT 971, 2'-FL 1,468, 3-FL 800, DFL 232, 3'-SL 212, 6'-SL 365, LNFP I 738, and LNT/LNnT 611. By groups of donors, the mean concentrations (mg/L, excluding colostrum) were: LNnT 382, LNT 1064.1, 2'-FL 1685, 3-FL 907, DFL 303, 3'-SL 225, 6'-SL 435, LNFP I 773, and LNT/LNnT 882. By publication, the mean concentration (mg/L) of groups of HMOs mean concentrations (excluding colostrum) was: 4,577 for total neutral; 851 for total acidic; 4,635 for total acidic fucosylated; 1,631 for α-1-3/4-fucosylated; 3,304 for α-1-2-fucosylated; 1,601 for non-fucosylated; 1,505 for total sialyllated; 2,293 for acidic sialyllated. By group of donors, the mean concentration (mg/L) of groups of HMOs mean concentrations (excluding colostrum) was: 3,942 for total neutral; 1,032 for total acidic; 6,477 for total acidic fucosylated; 1,650 for α-1-3/4-fucosylated; 3,748 for α-1-2-fucosylated; 2,026 for non-fucosylated; 1,957 for total sialyllated; 2,293 for acidic sialyllated. The most frequent combinations of HMOs/HiMOs were LNnT + 2'-FL (24 products, 32%) and 2'-FL + 3'-SL (12 products, 16%). Conclusions The findings of this review will support EFSA in the safety evaluation of HiMOs as NFs, in accordance with the EC mandate (M-2023-00157).

  @article{malih2024preparatory,
  abstract = {Abstract Background and aims This report describes a scoping literature review as preparatory work for the safety evaluation by EFSA of Human-identical Milk Oligosaccharides (HiMOs) as Novel Foods (NFs). The main objective was to gather information on the concentrations of Human Milk Oligosaccharides (HMOs) in human milk, both individual and total, and the combinations/mixtures of HiMOs/HMOs in commercially available products or those reported in the literature. Methods A scoping literature review was conducted, including a search strategy implemented in biomedical (PubMed) and multidisciplinary (Web of Science) databases from 2013 to March 2024, supplemented by an ad hoc search for primary studies included in two key recent systematic reviews and grey literature searches on relevant food business operators' websites. Both primary and secondary studies were selected to determine the individual concentrations of target HMOs, the total concentration of HMOs and relevant HMO fractions, and the combinations/mixtures of HiMOs/HMOs. Only studies with full text published in English or Spanish were eligible, excluding patents, editorials, conference abstracts, books, and dissertations. Results The structured searches yielded 2,851 unique references, with 218 selected for full-text evaluation and 36 additional unique references from the key systematic reviews. Ultimately, 171 publications were included in the review. Fourteen companies related to HiMOs were identified through grey literature. In most publications, concentration data for multiple groups of donors (e.g., based on factors like secretor status or lactation period) were reported. By groups of donors, the mean total concentration of HMOs in milk (excluding colostrum) was 6,740 mg/L, whereas the mean by publication was 5,341 mg/L. By publication, the mean concentrations of individual HMOs (mg/L, excluding colostrum) were: LNnT 288, LNT 971, 2'-FL 1,468, 3-FL 800, DFL 232, 3'-SL 212, 6'-SL 365, LNFP I 738, and LNT/LNnT 611. By groups of donors, the mean concentrations (mg/L, excluding colostrum) were: LNnT 382, LNT 1064.1, 2'-FL 1685, 3-FL 907, DFL 303, 3'-SL 225, 6'-SL 435, LNFP I 773, and LNT/LNnT 882. By publication, the mean concentration (mg/L) of groups of HMOs mean concentrations (excluding colostrum) was: 4,577 for total neutral; 851 for total acidic; 4,635 for total acidic fucosylated; 1,631 for α-1-3/4-fucosylated; 3,304 for α-1-2-fucosylated; 1,601 for non-fucosylated; 1,505 for total sialyllated; 2,293 for acidic sialyllated. By group of donors, the mean concentration (mg/L) of groups of HMOs mean concentrations (excluding colostrum) was: 3,942 for total neutral; 1,032 for total acidic; 6,477 for total acidic fucosylated; 1,650 for α-1-3/4-fucosylated; 3,748 for α-1-2-fucosylated; 2,026 for non-fucosylated; 1,957 for total sialyllated; 2,293 for acidic sialyllated. The most frequent combinations of HMOs/HiMOs were LNnT + 2'-FL (24 products, 32%) and 2'-FL + 3'-SL (12 products, 16%). Conclusions The findings of this review will support EFSA in the safety evaluation of HiMOs as NFs, in accordance with the EC mandate (M-2023-00157).},
  author = {Malih, Narges and Konieczna, Jadwiga and Fernandez, Mar Nafria and Fiol deRoque, Maria Antonia and Zamanillo-Campos, Rocío and Ricci-Cabello, Ignacio},
  booktitle = {EFSA Supporting Publications},
  keywords = {evisap},
  pages = {8955E},
  series = 7,
  title = {Preparatory work for the safety evaluation by EFSA of Human-identical Milk Oligosaccharides as Novel Foods},
  volume = 21,
  year = 2024
  }
  

  %0 Journal Article
  %1 malih2024preparatory
  %A Malih, Narges
  %A Konieczna, Jadwiga
  %A Fernandez, Mar Nafria
  %A Fiol deRoque, Maria Antonia
  %A Zamanillo-Campos, Rocío
  %A Ricci-Cabello, Ignacio
  %B EFSA Supporting Publications
  %D 2024
  %P 8955E
  %T Preparatory work for the safety evaluation by EFSA of Human-identical Milk Oligosaccharides as Novel Foods
  %U https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/sp.efsa.2024.EN-8955
  %V 21
  %X Abstract Background and aims This report describes a scoping literature review as preparatory work for the safety evaluation by EFSA of Human-identical Milk Oligosaccharides (HiMOs) as Novel Foods (NFs). The main objective was to gather information on the concentrations of Human Milk Oligosaccharides (HMOs) in human milk, both individual and total, and the combinations/mixtures of HiMOs/HMOs in commercially available products or those reported in the literature. Methods A scoping literature review was conducted, including a search strategy implemented in biomedical (PubMed) and multidisciplinary (Web of Science) databases from 2013 to March 2024, supplemented by an ad hoc search for primary studies included in two key recent systematic reviews and grey literature searches on relevant food business operators' websites. Both primary and secondary studies were selected to determine the individual concentrations of target HMOs, the total concentration of HMOs and relevant HMO fractions, and the combinations/mixtures of HiMOs/HMOs. Only studies with full text published in English or Spanish were eligible, excluding patents, editorials, conference abstracts, books, and dissertations. Results The structured searches yielded 2,851 unique references, with 218 selected for full-text evaluation and 36 additional unique references from the key systematic reviews. Ultimately, 171 publications were included in the review. Fourteen companies related to HiMOs were identified through grey literature. In most publications, concentration data for multiple groups of donors (e.g., based on factors like secretor status or lactation period) were reported. By groups of donors, the mean total concentration of HMOs in milk (excluding colostrum) was 6,740 mg/L, whereas the mean by publication was 5,341 mg/L. By publication, the mean concentrations of individual HMOs (mg/L, excluding colostrum) were: LNnT 288, LNT 971, 2'-FL 1,468, 3-FL 800, DFL 232, 3'-SL 212, 6'-SL 365, LNFP I 738, and LNT/LNnT 611. By groups of donors, the mean concentrations (mg/L, excluding colostrum) were: LNnT 382, LNT 1064.1, 2'-FL 1685, 3-FL 907, DFL 303, 3'-SL 225, 6'-SL 435, LNFP I 773, and LNT/LNnT 882. By publication, the mean concentration (mg/L) of groups of HMOs mean concentrations (excluding colostrum) was: 4,577 for total neutral; 851 for total acidic; 4,635 for total acidic fucosylated; 1,631 for α-1-3/4-fucosylated; 3,304 for α-1-2-fucosylated; 1,601 for non-fucosylated; 1,505 for total sialyllated; 2,293 for acidic sialyllated. By group of donors, the mean concentration (mg/L) of groups of HMOs mean concentrations (excluding colostrum) was: 3,942 for total neutral; 1,032 for total acidic; 6,477 for total acidic fucosylated; 1,650 for α-1-3/4-fucosylated; 3,748 for α-1-2-fucosylated; 2,026 for non-fucosylated; 1,957 for total sialyllated; 2,293 for acidic sialyllated. The most frequent combinations of HMOs/HiMOs were LNnT + 2'-FL (24 products, 32%) and 2'-FL + 3'-SL (12 products, 16%). Conclusions The findings of this review will support EFSA in the safety evaluation of HiMOs as NFs, in accordance with the EC mandate (M-2023-00157).
  

2023

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  1.

  Hajdarevic S, Högberg C, Marzo-Castillejo M, Siliņa V, Sawicka-Powierza J, Esteva M, Koskela T, Petek D, Contreras-Martos S, Mangione M, Ožvačić Adžić Z, Asenova R, Gašparović Babić S, Brekke M, Buczkowski K, Buono N, Çifçili SS, Dinant GJ, Doorn B, Hoffman RD, Kuodza G, Murchie P, Pilv L, Puia A, Rapalavicius A, Smyrnakis E, Weltermann B, Harris M. Exploring why European primary care physicians sometimes do not think of, or act on, a possible cancer diagnosis. A qualitative study. BJGP Open. 2023;7(4).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: While primary care physicians (PCPs) play a key role in cancer detection, they can find cancer diagnosis challenging, and some patients have considerable delays between presentation and onward referral. AIM: To explore European PCPs' experiences and views on cases where they considered that they had been slow to think of, or act on, a possible cancer diagnosis. DESIGN & SETTING: A multicentre European qualitative study, based on an online survey with open-ended questions, asking PCPs for their narratives about cases when they had missed a diagnosis of cancer. METHOD: Using maximum variation sampling, PCPs in 23 European countries were asked to describe what happened in a case where they were slow to think of a cancer diagnosis, and for their views on why it happened. Thematic analysis was used to analyse the data. RESULTS: A total of 158 PCPs completed the questionnaire. The main themes were as follows: patients' descriptions did not suggest cancer; distracting factors reduced PCPs' cancer suspicions; patients' hesitancy delayed the diagnosis; system factors not facilitating timely diagnosis; PCPs felt that they had acted wrongly; and problems with communicating adequately. CONCLUSION: The study identified six overarching themes that need to be addressed. Doing so should reduce morbidity and mortality in the small proportion of patients who have a significant, avoidable delay in their cancer diagnosis. The 'Swiss cheese' model of accident causation showed how the themes related to each other.

  @article{RN76,
  abstract = {BACKGROUND: While primary care physicians (PCPs) play a key role in cancer detection, they can find cancer diagnosis challenging, and some patients have considerable delays between presentation and onward referral. AIM: To explore European PCPs' experiences and views on cases where they considered that they had been slow to think of, or act on, a possible cancer diagnosis. DESIGN & SETTING: A multicentre European qualitative study, based on an online survey with open-ended questions, asking PCPs for their narratives about cases when they had missed a diagnosis of cancer. METHOD: Using maximum variation sampling, PCPs in 23 European countries were asked to describe what happened in a case where they were slow to think of a cancer diagnosis, and for their views on why it happened. Thematic analysis was used to analyse the data. RESULTS: A total of 158 PCPs completed the questionnaire. The main themes were as follows: patients' descriptions did not suggest cancer; distracting factors reduced PCPs' cancer suspicions; patients' hesitancy delayed the diagnosis; system factors not facilitating timely diagnosis; PCPs felt that they had acted wrongly; and problems with communicating adequately. CONCLUSION: The study identified six overarching themes that need to be addressed. Doing so should reduce morbidity and mortality in the small proportion of patients who have a significant, avoidable delay in their cancer diagnosis. The 'Swiss cheese' model of accident causation showed how the themes related to each other.},
  author = {Hajdarevic, S. and Högberg, C. and Marzo-Castillejo, M. and Siliņa, V. and Sawicka-Powierza, J. and Esteva, M. and Koskela, T. and Petek, D. and Contreras-Martos, S. and Mangione, M. and Ožvačić Adžić, Z. and Asenova, R. and Gašparović Babić, S. and Brekke, M. and Buczkowski, K. and Buono, N. and Çifçili, S. S. and Dinant, G. J. and Doorn, B. and Hoffman, R. D. and Kuodza, G. and Murchie, P. and Pilv, L. and Puia, A. and Rapalavicius, A. and Smyrnakis, E. and Weltermann, B. and Harris, M.},
  journal = {BJGP Open},
  keywords = {grapp-caib},
  number = 4,
  title = {Exploring why European primary care physicians sometimes do not think of, or act on, a possible cancer diagnosis. A qualitative study},
  type = {Journal Article},
  volume = 7,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN76
  %A Hajdarevic, S.
  %A Högberg, C.
  %A Marzo-Castillejo, M.
  %A Siliņa, V.
  %A Sawicka-Powierza, J.
  %A Esteva, M.
  %A Koskela, T.
  %A Petek, D.
  %A Contreras-Martos, S.
  %A Mangione, M.
  %A Ožvačić Adžić, Z.
  %A Asenova, R.
  %A Gašparović Babić, S.
  %A Brekke, M.
  %A Buczkowski, K.
  %A Buono, N.
  %A Çifçili, S. S.
  %A Dinant, G. J.
  %A Doorn, B.
  %A Hoffman, R. D.
  %A Kuodza, G.
  %A Murchie, P.
  %A Pilv, L.
  %A Puia, A.
  %A Rapalavicius, A.
  %A Smyrnakis, E.
  %A Weltermann, B.
  %A Harris, M.
  %D 2023
  %J BJGP Open
  %N 4
  %R 10.3399/bjgpo.2023.0029
  %T Exploring why European primary care physicians sometimes do not think of, or act on, a possible cancer diagnosis. A qualitative study
  %V 7
  %X BACKGROUND: While primary care physicians (PCPs) play a key role in cancer detection, they can find cancer diagnosis challenging, and some patients have considerable delays between presentation and onward referral. AIM: To explore European PCPs' experiences and views on cases where they considered that they had been slow to think of, or act on, a possible cancer diagnosis. DESIGN & SETTING: A multicentre European qualitative study, based on an online survey with open-ended questions, asking PCPs for their narratives about cases when they had missed a diagnosis of cancer. METHOD: Using maximum variation sampling, PCPs in 23 European countries were asked to describe what happened in a case where they were slow to think of a cancer diagnosis, and for their views on why it happened. Thematic analysis was used to analyse the data. RESULTS: A total of 158 PCPs completed the questionnaire. The main themes were as follows: patients' descriptions did not suggest cancer; distracting factors reduced PCPs' cancer suspicions; patients' hesitancy delayed the diagnosis; system factors not facilitating timely diagnosis; PCPs felt that they had acted wrongly; and problems with communicating adequately. CONCLUSION: The study identified six overarching themes that need to be addressed. Doing so should reduce morbidity and mortality in the small proportion of patients who have a significant, avoidable delay in their cancer diagnosis. The 'Swiss cheese' model of accident causation showed how the themes related to each other.
  

• 
  1.

  Gallardo-Alfaro L, Lorente-Montalvo P, Cañellas M, Carandell E, Oliver A, Rojo E, Riera B, Llobera J, Bulilete O. Diagnostic accuracy of Panbio™ rapid antigen test for SARS-CoV-2 in paediatric population. BMC Pediatr. 2023;23(1):433.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Rapid antigen-detection tests (Ag-RDTs) are used to diagnose SARS-CoV-2 infection. Real-world studies of Ag-RDTs are necessary to evaluate their diagnostic yield in paediatric patients. Our aim was to evaluate the accuracy of the Panbio™ Rapid Antigen Test for SARS-CoV-2 in the setting of a primary health care centre (PHC), with use of the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) as gold standard. METHODS: This prospective diagnostic study was conducted at PHCs in Mallorca, Spain. Patients were ≤ 18 years-old that attended sites for RT-PCR testing due to symptoms suggestive of infection (fever, headache, nasal congestion and dry cough, among others) or epidemiological exposure (close contacts). Two samples were collected: a nasal mid-turbinate sample for Ag-RDTs and a nasopharyngeal swab for RT-PCR testing. The sensitivity, specificity, and predictive values of the AgRDT were calculated using the RT-PCR results as the reference. RESULTS: We examined 1142 participants from 0 to 18 years (47.5% female, mean age 8.9 ± 4.8 years, median 9.0 [5.0-13.0]). There were 84 positive RT-PCR results (pre-test probability of 7.3%) and 52 positive Ag-RDT results. The sensitivity of the Ag-RDT was 59.5% (95% Confidence Interval (CI): 48.2-69.9%), the specificity was 99.8% (95%CI: 99.2-99.9%), the positive predictive value was 96.1% (95%CI: 85.6-99.4%), and the negative predictive value was 96.8% (95%CI: 95.6-97.7%). The sensitivity for individuals referred by a general practitioner (GP) or paediatrician due to symptoms was 71.4% (95%CI: 51.5-86.0%) and for asymptomatic individuals was 50.0% (95%CI: 9.1-90.8%). The specificity was greater than 98.9% overall and in all subgroups. The sensitivity was 73.0% (95%CI: 52.0-87.5%) for referred patients due to symptoms and who were tested within 5 days since symptom onset. No significant statistical differences between any groups were found. There were 34 false-negative Ag-RDT results (40.5%) and 2 false-positive Ag-RDT results (0.2%). CONCLUSION: The sensitivity of the Panbio™ Test in paediatric individuals is below the minimum of 80% recommended by the World Health Organization for Ag-RDTs. This test had better accuracy in individuals referred by a GP or paediatrician due to symptoms, rather than those who were asymptomatic or referred due to epidemiological exposure. The RT-PCR test using a nasopharyngeal swab is accurate, but a less invasive alternative that has better sensitivity than the Panbio™ Test is needed for paediatric populations.

  @article{RN50,
  abstract = {BACKGROUND: Rapid antigen-detection tests (Ag-RDTs) are used to diagnose SARS-CoV-2 infection. Real-world studies of Ag-RDTs are necessary to evaluate their diagnostic yield in paediatric patients. Our aim was to evaluate the accuracy of the Panbio™ Rapid Antigen Test for SARS-CoV-2 in the setting of a primary health care centre (PHC), with use of the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) as gold standard. METHODS: This prospective diagnostic study was conducted at PHCs in Mallorca, Spain. Patients were ≤ 18 years-old that attended sites for RT-PCR testing due to symptoms suggestive of infection (fever, headache, nasal congestion and dry cough, among others) or epidemiological exposure (close contacts). Two samples were collected: a nasal mid-turbinate sample for Ag-RDTs and a nasopharyngeal swab for RT-PCR testing. The sensitivity, specificity, and predictive values of the AgRDT were calculated using the RT-PCR results as the reference. RESULTS: We examined 1142 participants from 0 to 18 years (47.5% female, mean age 8.9 ± 4.8 years, median 9.0 [5.0-13.0]). There were 84 positive RT-PCR results (pre-test probability of 7.3%) and 52 positive Ag-RDT results. The sensitivity of the Ag-RDT was 59.5% (95% Confidence Interval (CI): 48.2-69.9%), the specificity was 99.8% (95%CI: 99.2-99.9%), the positive predictive value was 96.1% (95%CI: 85.6-99.4%), and the negative predictive value was 96.8% (95%CI: 95.6-97.7%). The sensitivity for individuals referred by a general practitioner (GP) or paediatrician due to symptoms was 71.4% (95%CI: 51.5-86.0%) and for asymptomatic individuals was 50.0% (95%CI: 9.1-90.8%). The specificity was greater than 98.9% overall and in all subgroups. The sensitivity was 73.0% (95%CI: 52.0-87.5%) for referred patients due to symptoms and who were tested within 5 days since symptom onset. No significant statistical differences between any groups were found. There were 34 false-negative Ag-RDT results (40.5%) and 2 false-positive Ag-RDT results (0.2%). CONCLUSION: The sensitivity of the Panbio™ Test in paediatric individuals is below the minimum of 80% recommended by the World Health Organization for Ag-RDTs. This test had better accuracy in individuals referred by a GP or paediatrician due to symptoms, rather than those who were asymptomatic or referred due to epidemiological exposure. The RT-PCR test using a nasopharyngeal swab is accurate, but a less invasive alternative that has better sensitivity than the Panbio™ Test is needed for paediatric populations.},
  author = {Gallardo-Alfaro, L. and Lorente-Montalvo, P. and Cañellas, M. and Carandell, E. and Oliver, A. and Rojo, E. and Riera, B. and Llobera, J. and Bulilete, O.},
  journal = {BMC Pediatr},
  keywords = {grapp-caib},
  number = 1,
  pages = 433,
  title = {Diagnostic accuracy of Panbio™ rapid antigen test for SARS-CoV-2 in paediatric population},
  type = {Journal Article},
  volume = 23,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN50
  %A Gallardo-Alfaro, L.
  %A Lorente-Montalvo, P.
  %A Cañellas, M.
  %A Carandell, E.
  %A Oliver, A.
  %A Rojo, E.
  %A Riera, B.
  %A Llobera, J.
  %A Bulilete, O.
  %D 2023
  %J BMC Pediatr
  %N 1
  %P 433
  %R 10.1186/s12887-023-04201-z
  %T Diagnostic accuracy of Panbio™ rapid antigen test for SARS-CoV-2 in paediatric population
  %V 23
  %X BACKGROUND: Rapid antigen-detection tests (Ag-RDTs) are used to diagnose SARS-CoV-2 infection. Real-world studies of Ag-RDTs are necessary to evaluate their diagnostic yield in paediatric patients. Our aim was to evaluate the accuracy of the Panbio™ Rapid Antigen Test for SARS-CoV-2 in the setting of a primary health care centre (PHC), with use of the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) as gold standard. METHODS: This prospective diagnostic study was conducted at PHCs in Mallorca, Spain. Patients were ≤ 18 years-old that attended sites for RT-PCR testing due to symptoms suggestive of infection (fever, headache, nasal congestion and dry cough, among others) or epidemiological exposure (close contacts). Two samples were collected: a nasal mid-turbinate sample for Ag-RDTs and a nasopharyngeal swab for RT-PCR testing. The sensitivity, specificity, and predictive values of the AgRDT were calculated using the RT-PCR results as the reference. RESULTS: We examined 1142 participants from 0 to 18 years (47.5% female, mean age 8.9 ± 4.8 years, median 9.0 [5.0-13.0]). There were 84 positive RT-PCR results (pre-test probability of 7.3%) and 52 positive Ag-RDT results. The sensitivity of the Ag-RDT was 59.5% (95% Confidence Interval (CI): 48.2-69.9%), the specificity was 99.8% (95%CI: 99.2-99.9%), the positive predictive value was 96.1% (95%CI: 85.6-99.4%), and the negative predictive value was 96.8% (95%CI: 95.6-97.7%). The sensitivity for individuals referred by a general practitioner (GP) or paediatrician due to symptoms was 71.4% (95%CI: 51.5-86.0%) and for asymptomatic individuals was 50.0% (95%CI: 9.1-90.8%). The specificity was greater than 98.9% overall and in all subgroups. The sensitivity was 73.0% (95%CI: 52.0-87.5%) for referred patients due to symptoms and who were tested within 5 days since symptom onset. No significant statistical differences between any groups were found. There were 34 false-negative Ag-RDT results (40.5%) and 2 false-positive Ag-RDT results (0.2%). CONCLUSION: The sensitivity of the Panbio™ Test in paediatric individuals is below the minimum of 80% recommended by the World Health Organization for Ag-RDTs. This test had better accuracy in individuals referred by a GP or paediatrician due to symptoms, rather than those who were asymptomatic or referred due to epidemiological exposure. The RT-PCR test using a nasopharyngeal swab is accurate, but a less invasive alternative that has better sensitivity than the Panbio™ Test is needed for paediatric populations.
  

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  1.

  Alonso-Bernáldez M, Palou-March A, Zamanillo-Campos R, Palou A, Palou M, Serra F. A Diet Profiling Algorithm (DPA) to Rank Diet Quality Suitable to Implement in Digital Tools-A Test Study in a Cohort of Lactating Women. Nutrients [Internet]. Switzerland; 2023 Mar.;15(6):1337-. https://pubmed.ncbi.nlm.nih.gov/36986066

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Although nutrient profiling systems can empower consumers towards healthier food choices, there is still a need to assess diet quality to obtain an overall perspective. The purpose of this study was to develop a diet profiling algorithm (DPA) to evaluate nutritional diet quality, which gives a final score from 1 to 3 with an associated color (green-yellow-orange). It ranks the total carbohydrate/total fiber ratio, and energy from saturated fats and sodium as potentially negative inputs, while fiber and protein are assumed as positive items. Then, the total fat/total carbohydrate ratio is calculated to evaluate the macronutrient distribution, as well as a food group analysis. To test the DPA performance, diets of a lactating women cohort were analyzed, and a correlation analysis between DPA and breast milk leptin levels was performed. Diets classified as low quality showed a higher intake of negative inputs, along with higher energy and fat intakes. This was reflected in body mass index (BMI) and food groups, indicating that women with the worst scores tended to choose tastier and less satiating foods. In conclusion, the DPA was developed and tested in a sample population. This tool can be easily implemented in digital nutrition platforms, contributing to real-time dietary follow-up of patients and progress monitoring, leading to further dietary adjustment.

  @article{alonsobernaldez2023profiling,
  abstract = {Although nutrient profiling systems can empower consumers towards healthier food choices, there is still a need to assess diet quality to obtain an overall perspective. The purpose of this study was to develop a diet profiling algorithm (DPA) to evaluate nutritional diet quality, which gives a final score from 1 to 3 with an associated color (green-yellow-orange). It ranks the total carbohydrate/total fiber ratio, and energy from saturated fats and sodium as potentially negative inputs, while fiber and protein are assumed as positive items. Then, the total fat/total carbohydrate ratio is calculated to evaluate the macronutrient distribution, as well as a food group analysis. To test the DPA performance, diets of a lactating women cohort were analyzed, and a correlation analysis between DPA and breast milk leptin levels was performed. Diets classified as low quality showed a higher intake of negative inputs, along with higher energy and fat intakes. This was reflected in body mass index (BMI) and food groups, indicating that women with the worst scores tended to choose tastier and less satiating foods. In conclusion, the DPA was developed and tested in a sample population. This tool can be easily implemented in digital nutrition platforms, contributing to real-time dietary follow-up of patients and progress monitoring, leading to further dietary adjustment.},
  address = {Switzerland},
  author = {Alonso-Bernáldez, Marta and Palou-March, Andreu and Zamanillo-Campos, Rocío and Palou, Andreu and Palou, Mariona and Serra, Francisca},
  journal = {Nutrients},
  keywords = {evisap},
  month = {mar},
  number = 6,
  pages = {1337--},
  title = {A Diet Profiling Algorithm (DPA) to Rank Diet Quality Suitable to Implement in Digital Tools-A Test Study in a Cohort of Lactating Women},
  volume = 15,
  year = 2023
  }
  

  %0 Journal Article
  %1 alonsobernaldez2023profiling
  %A Alonso-Bernáldez, Marta
  %A Palou-March, Andreu
  %A Zamanillo-Campos, Rocío
  %A Palou, Andreu
  %A Palou, Mariona
  %A Serra, Francisca
  %C Switzerland
  %D 2023
  %J Nutrients
  %N 6
  %P 1337--
  %R 10.3390/nu15061337
  %T A Diet Profiling Algorithm (DPA) to Rank Diet Quality Suitable to Implement in Digital Tools-A Test Study in a Cohort of Lactating Women
  %U https://pubmed.ncbi.nlm.nih.gov/36986066
  %V 15
  %X Although nutrient profiling systems can empower consumers towards healthier food choices, there is still a need to assess diet quality to obtain an overall perspective. The purpose of this study was to develop a diet profiling algorithm (DPA) to evaluate nutritional diet quality, which gives a final score from 1 to 3 with an associated color (green-yellow-orange). It ranks the total carbohydrate/total fiber ratio, and energy from saturated fats and sodium as potentially negative inputs, while fiber and protein are assumed as positive items. Then, the total fat/total carbohydrate ratio is calculated to evaluate the macronutrient distribution, as well as a food group analysis. To test the DPA performance, diets of a lactating women cohort were analyzed, and a correlation analysis between DPA and breast milk leptin levels was performed. Diets classified as low quality showed a higher intake of negative inputs, along with higher energy and fat intakes. This was reflected in body mass index (BMI) and food groups, indicating that women with the worst scores tended to choose tastier and less satiating foods. In conclusion, the DPA was developed and tested in a sample population. This tool can be easily implemented in digital nutrition platforms, contributing to real-time dietary follow-up of patients and progress monitoring, leading to further dietary adjustment.
  

• 
  1.

  Chela-Alvarez X, Bulilete O, García-Buades ME, Ferrer-Perez VA, Llobera J. Workplace bullying and sexual harassment at work among hotel housekeepers in the Balearic Islands (Spain). Front Psychol. 2023;14:1241255.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  INTRODUCTION: Hotel housekeepers are close to being a 100% feminized occupational group in Spain. This fact, coupled with some features of the job, places them at high risk of sexual harassment at work and bullying in the workplace. This study aims to explore experiences of sexual harassment at work and workplace bullying among hotel housekeepers in the Balearic Islands. Second, it aims to describe and estimate the prevalence of both phenomena. METHODS: This is a mixed-methods study. Ten semi-structured interviews were conducted with key informants, and six focus groups were held with hotel housekeepers. Additionally, a quantitative cross-sectional study (n = 1,043) was undertaken. RESULTS: Most participants in focus groups had been sexually harassed at work. However, they had normalized this kind of situations, not labeling themselves as victims of sexual harassment; and harassment events were seen as unimportant, normal, and unquestioned, as well as being part of their daily work. Hotel housekeepers who were sexually harassed indicated high levels of stress at work and low social support. The prevalence of different workplace bullying behaviors was quite high among hotel housekeepers working in the Balearic Islands. Some were associated with poorer self-rated health, less satisfaction with the job and the salary, lower social support, and higher levels of stress. Despite this, qualitative methods informed us that less severe behaviors were normalized and perceived by hotel housekeepers as intrinsic to their job. DISCUSSION: The results show the high tolerance to less severe expressions of sexual harassment at work and workplace bullying, as well as difficulties in or reluctance to labeling this kind of experiences as such.

  @article{RN364,
  abstract = {INTRODUCTION: Hotel housekeepers are close to being a 100% feminized occupational group in Spain. This fact, coupled with some features of the job, places them at high risk of sexual harassment at work and bullying in the workplace. This study aims to explore experiences of sexual harassment at work and workplace bullying among hotel housekeepers in the Balearic Islands. Second, it aims to describe and estimate the prevalence of both phenomena. METHODS: This is a mixed-methods study. Ten semi-structured interviews were conducted with key informants, and six focus groups were held with hotel housekeepers. Additionally, a quantitative cross-sectional study (n = 1,043) was undertaken. RESULTS: Most participants in focus groups had been sexually harassed at work. However, they had normalized this kind of situations, not labeling themselves as victims of sexual harassment; and harassment events were seen as unimportant, normal, and unquestioned, as well as being part of their daily work. Hotel housekeepers who were sexually harassed indicated high levels of stress at work and low social support. The prevalence of different workplace bullying behaviors was quite high among hotel housekeepers working in the Balearic Islands. Some were associated with poorer self-rated health, less satisfaction with the job and the salary, lower social support, and higher levels of stress. Despite this, qualitative methods informed us that less severe behaviors were normalized and perceived by hotel housekeepers as intrinsic to their job. DISCUSSION: The results show the high tolerance to less severe expressions of sexual harassment at work and workplace bullying, as well as difficulties in or reluctance to labeling this kind of experiences as such.},
  author = {Chela-Alvarez, X. and Bulilete, O. and García-Buades, M. E. and Ferrer-Perez, V. A. and Llobera, J.},
  journal = {Front Psychol},
  keywords = {grapp-caib},
  pages = 1241255,
  title = {Workplace bullying and sexual harassment at work among hotel housekeepers in the Balearic Islands (Spain)},
  type = {Journal Article},
  volume = 14,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN364
  %A Chela-Alvarez, X.
  %A Bulilete, O.
  %A García-Buades, M. E.
  %A Ferrer-Perez, V. A.
  %A Llobera, J.
  %D 2023
  %J Front Psychol
  %P 1241255
  %R 10.3389/fpsyg.2023.1241255
  %T Workplace bullying and sexual harassment at work among hotel housekeepers in the Balearic Islands (Spain)
  %V 14
  %X INTRODUCTION: Hotel housekeepers are close to being a 100% feminized occupational group in Spain. This fact, coupled with some features of the job, places them at high risk of sexual harassment at work and bullying in the workplace. This study aims to explore experiences of sexual harassment at work and workplace bullying among hotel housekeepers in the Balearic Islands. Second, it aims to describe and estimate the prevalence of both phenomena. METHODS: This is a mixed-methods study. Ten semi-structured interviews were conducted with key informants, and six focus groups were held with hotel housekeepers. Additionally, a quantitative cross-sectional study (n = 1,043) was undertaken. RESULTS: Most participants in focus groups had been sexually harassed at work. However, they had normalized this kind of situations, not labeling themselves as victims of sexual harassment; and harassment events were seen as unimportant, normal, and unquestioned, as well as being part of their daily work. Hotel housekeepers who were sexually harassed indicated high levels of stress at work and low social support. The prevalence of different workplace bullying behaviors was quite high among hotel housekeepers working in the Balearic Islands. Some were associated with poorer self-rated health, less satisfaction with the job and the salary, lower social support, and higher levels of stress. Despite this, qualitative methods informed us that less severe behaviors were normalized and perceived by hotel housekeepers as intrinsic to their job. DISCUSSION: The results show the high tolerance to less severe expressions of sexual harassment at work and workplace bullying, as well as difficulties in or reluctance to labeling this kind of experiences as such.
  

• 
  1.

  Ramírez-Manent JI, López-González Á A, Tomás-Gil P, Riutord-Sbert P, Garrido-Sepulveda L, Vicente-Herrero MT. Relationship between Abdominal Volume Index and Body Adiposity Index and Scales of Insulin Resistance and Metabolic Syndrome. Diagnostics (Basel). 2023;13(21).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  Introduction, objectives: Obesity is a global health problem with a great negative impact on health. Among the pathologies caused by obesity are insulin resistance and metabolic syndrome, which constitute an increasingly common health problem in both developed and developing countries. The aim of this study was to examine the relationship between two scales that assess obesity-based on hip circumference-and metabolic syndrome (MetS) and insulin resistance risk scales as predictors of these alterations. MATERIALS, METHODS: A descriptive, cross-sectional study was carried out on 193,462 workers from different Spanish regions and work groups between January 2019 and September 2021. Abdominal volume index (AVI) and body adiposity index (BAI) were evaluated to assess obesity and its association with insulin resistance using three risk scales (TyG index, Triglycerides/HDL, and METS-IR), while their association with metabolic syndrome was determined using the NCEP ATP III, IDF, and JIS models. RESULTS: The results of the ROC curves to determine the predictive value of BAI and AVI in relation to the three criteria evaluated to calculate MetS in all instances presented a higher area under the curve (AUC) for AVI. The high values of AVI stand out for predicting MetS when applying the IDF criteria. The cut-off point in women was 13.70 with a Youden index of 0.802, whereas in men, the cut-off point was set at 17.59 with a Youden index of 0.672. Regarding the relationship of BAI and AVI with insulin resistance risk scales for both sexes, the AUC only revealed high values when using the METS-IR formula for both AVI and BAI. The AVI cut-off points to predict high values of insulin resistance risk scales in women were established at 13.12 with a Youden index of 0.722. In men, the cut-off point was 17.59, with a Youden index of 0.626. The BAI cut-off points in women were set at 33.88 with a Youden index of 0.748. In men, the cut-off point was 27.91, with a Youden index of 0.598. CONCLUSIONS: AVI demonstrated its value as a predictor of metabolic syndrome while exclusively applying the IDF criteria. AVI and BAI demonstrated their value as predictors of high values of insulin resistance risk scales only in the case of METS-IR. This predictive value is also higher in women.

  @article{RN44,
  abstract = {Introduction, objectives: Obesity is a global health problem with a great negative impact on health. Among the pathologies caused by obesity are insulin resistance and metabolic syndrome, which constitute an increasingly common health problem in both developed and developing countries. The aim of this study was to examine the relationship between two scales that assess obesity-based on hip circumference-and metabolic syndrome (MetS) and insulin resistance risk scales as predictors of these alterations. MATERIALS, METHODS: A descriptive, cross-sectional study was carried out on 193,462 workers from different Spanish regions and work groups between January 2019 and September 2021. Abdominal volume index (AVI) and body adiposity index (BAI) were evaluated to assess obesity and its association with insulin resistance using three risk scales (TyG index, Triglycerides/HDL, and METS-IR), while their association with metabolic syndrome was determined using the NCEP ATP III, IDF, and JIS models. RESULTS: The results of the ROC curves to determine the predictive value of BAI and AVI in relation to the three criteria evaluated to calculate MetS in all instances presented a higher area under the curve (AUC) for AVI. The high values of AVI stand out for predicting MetS when applying the IDF criteria. The cut-off point in women was 13.70 with a Youden index of 0.802, whereas in men, the cut-off point was set at 17.59 with a Youden index of 0.672. Regarding the relationship of BAI and AVI with insulin resistance risk scales for both sexes, the AUC only revealed high values when using the METS-IR formula for both AVI and BAI. The AVI cut-off points to predict high values of insulin resistance risk scales in women were established at 13.12 with a Youden index of 0.722. In men, the cut-off point was 17.59, with a Youden index of 0.626. The BAI cut-off points in women were set at 33.88 with a Youden index of 0.748. In men, the cut-off point was 27.91, with a Youden index of 0.598. CONCLUSIONS: AVI demonstrated its value as a predictor of metabolic syndrome while exclusively applying the IDF criteria. AVI and BAI demonstrated their value as predictors of high values of insulin resistance risk scales only in the case of METS-IR. This predictive value is also higher in women.},
  author = {Ramírez-Manent, J. I. and López-González Á, A. and Tomás-Gil, P. and Riutord-Sbert, P. and Garrido-Sepulveda, L. and Vicente-Herrero, M. T.},
  journal = {Diagnostics (Basel)},
  keywords = {grapp-caib},
  number = 21,
  title = {Relationship between Abdominal Volume Index and Body Adiposity Index and Scales of Insulin Resistance and Metabolic Syndrome},
  type = {Journal Article},
  volume = 13,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN44
  %A Ramírez-Manent, J. I.
  %A López-González Á, A.
  %A Tomás-Gil, P.
  %A Riutord-Sbert, P.
  %A Garrido-Sepulveda, L.
  %A Vicente-Herrero, M. T.
  %D 2023
  %J Diagnostics (Basel)
  %N 21
  %R 10.3390/diagnostics13213356
  %T Relationship between Abdominal Volume Index and Body Adiposity Index and Scales of Insulin Resistance and Metabolic Syndrome
  %V 13
  %X Introduction, objectives: Obesity is a global health problem with a great negative impact on health. Among the pathologies caused by obesity are insulin resistance and metabolic syndrome, which constitute an increasingly common health problem in both developed and developing countries. The aim of this study was to examine the relationship between two scales that assess obesity-based on hip circumference-and metabolic syndrome (MetS) and insulin resistance risk scales as predictors of these alterations. MATERIALS, METHODS: A descriptive, cross-sectional study was carried out on 193,462 workers from different Spanish regions and work groups between January 2019 and September 2021. Abdominal volume index (AVI) and body adiposity index (BAI) were evaluated to assess obesity and its association with insulin resistance using three risk scales (TyG index, Triglycerides/HDL, and METS-IR), while their association with metabolic syndrome was determined using the NCEP ATP III, IDF, and JIS models. RESULTS: The results of the ROC curves to determine the predictive value of BAI and AVI in relation to the three criteria evaluated to calculate MetS in all instances presented a higher area under the curve (AUC) for AVI. The high values of AVI stand out for predicting MetS when applying the IDF criteria. The cut-off point in women was 13.70 with a Youden index of 0.802, whereas in men, the cut-off point was set at 17.59 with a Youden index of 0.672. Regarding the relationship of BAI and AVI with insulin resistance risk scales for both sexes, the AUC only revealed high values when using the METS-IR formula for both AVI and BAI. The AVI cut-off points to predict high values of insulin resistance risk scales in women were established at 13.12 with a Youden index of 0.722. In men, the cut-off point was 17.59, with a Youden index of 0.626. The BAI cut-off points in women were set at 33.88 with a Youden index of 0.748. In men, the cut-off point was 27.91, with a Youden index of 0.598. CONCLUSIONS: AVI demonstrated its value as a predictor of metabolic syndrome while exclusively applying the IDF criteria. AVI and BAI demonstrated their value as predictors of high values of insulin resistance risk scales only in the case of METS-IR. This predictive value is also higher in women.
  

• 
  1.

  Ballester A-R, Roqué M, Ricci-Cabello I, Rotger A, Malih N. Horizon scanning on microorganisms and their products obtained by new developments in biotechnology. EFSA Supporting Publications [Internet]. 2023;20(12):8503E. https://doi.org/10.2903/sp.efsa.2023.EN-8503

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  Abstract Background The aim of this horizon scanning is to map applications of new genomic techniques (NGTs) developed after Directive 2001/18/EC to obtain genetically modified microorganisms (GMMs) of categories 3 and 4, with an application to the agri-food and feed sectors; as well as understanding their relevant safety and risk assessment aspects. Methods The review comprised systematic comprehensive searches for the identification of relevant applications: i) structured electronic searches in Medline, EMBASE, and Web of Science, and ii) searches in on-line resources, including websites of companies, regulatory agencies, patents, and registries. Results we identified 35 GMMs meeting the eligibility criteria. An evidence table (available in a separate file) offers a detailed description of their characteristics. Most of the GMMs were developed or commercialised by institutions in China or USA (14 and 10 cases, respectively). Of the 35 GMMs identified, 11 were bacteria, 22 yeasts, one fungal endophyte, and one microalga. As for use, 30 GMMs were used as (or as a source of) food or food additives, three as (or as a source of) feed or feed additives, and two for agricultural purposes. Eight GMMs are already commercialized, 9 are published in patent applications, and 18 are under development. When considering the purpose of the new traits introduced, 10 GMMs modify flavours in food; 10 increase the bioproduction of compounds; seven improve food profile/composition; two boost immunity/reduce toxicity in feed additives; five optimize food production processes, and one increases nitrogen-fixation as fertiliser. Only three identified GMMs have been subjected to an authorisation process by national or international authorities, and risk assessment studies are scarcely available. The findings of this horizon scan illustrate the growing worldwide adoption of NGTs in producing GMMs for application in the food and feed sectors.

  @article{RN24,
  abstract = {Abstract Background The aim of this horizon scanning is to map applications of new genomic techniques (NGTs) developed after Directive 2001/18/EC to obtain genetically modified microorganisms (GMMs) of categories 3 and 4, with an application to the agri-food and feed sectors; as well as understanding their relevant safety and risk assessment aspects. Methods The review comprised systematic comprehensive searches for the identification of relevant applications: i) structured electronic searches in Medline, EMBASE, and Web of Science, and ii) searches in on-line resources, including websites of companies, regulatory agencies, patents, and registries. Results we identified 35 GMMs meeting the eligibility criteria. An evidence table (available in a separate file) offers a detailed description of their characteristics. Most of the GMMs were developed or commercialised by institutions in China or USA (14 and 10 cases, respectively). Of the 35 GMMs identified, 11 were bacteria, 22 yeasts, one fungal endophyte, and one microalga. As for use, 30 GMMs were used as (or as a source of) food or food additives, three as (or as a source of) feed or feed additives, and two for agricultural purposes. Eight GMMs are already commercialized, 9 are published in patent applications, and 18 are under development. When considering the purpose of the new traits introduced, 10 GMMs modify flavours in food; 10 increase the bioproduction of compounds; seven improve food profile/composition; two boost immunity/reduce toxicity in feed additives; five optimize food production processes, and one increases nitrogen-fixation as fertiliser. Only three identified GMMs have been subjected to an authorisation process by national or international authorities, and risk assessment studies are scarcely available. The findings of this horizon scan illustrate the growing worldwide adoption of NGTs in producing GMMs for application in the food and feed sectors.},
  author = {Ballester, Ana-Rosa and Roqué, Marta and Ricci-Cabello, Ignacio and Rotger, Andreu and Malih, Narges},
  journal = {EFSA Supporting Publications},
  keywords = {evisap grapp-caib},
  number = 12,
  pages = {8503E},
  title = {Horizon scanning on microorganisms and their products obtained by new developments in biotechnology},
  type = {Journal Article},
  volume = 20,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN24
  %A Ballester, Ana-Rosa
  %A Roqué, Marta
  %A Ricci-Cabello, Ignacio
  %A Rotger, Andreu
  %A Malih, Narges
  %D 2023
  %J EFSA Supporting Publications
  %N 12
  %P 8503E
  %R https://doi.org/10.2903/sp.efsa.2023.EN-8503
  %T Horizon scanning on microorganisms and their products obtained by new developments in biotechnology
  %U https://doi.org/10.2903/sp.efsa.2023.EN-8503
  %V 20
  %X Abstract Background The aim of this horizon scanning is to map applications of new genomic techniques (NGTs) developed after Directive 2001/18/EC to obtain genetically modified microorganisms (GMMs) of categories 3 and 4, with an application to the agri-food and feed sectors; as well as understanding their relevant safety and risk assessment aspects. Methods The review comprised systematic comprehensive searches for the identification of relevant applications: i) structured electronic searches in Medline, EMBASE, and Web of Science, and ii) searches in on-line resources, including websites of companies, regulatory agencies, patents, and registries. Results we identified 35 GMMs meeting the eligibility criteria. An evidence table (available in a separate file) offers a detailed description of their characteristics. Most of the GMMs were developed or commercialised by institutions in China or USA (14 and 10 cases, respectively). Of the 35 GMMs identified, 11 were bacteria, 22 yeasts, one fungal endophyte, and one microalga. As for use, 30 GMMs were used as (or as a source of) food or food additives, three as (or as a source of) feed or feed additives, and two for agricultural purposes. Eight GMMs are already commercialized, 9 are published in patent applications, and 18 are under development. When considering the purpose of the new traits introduced, 10 GMMs modify flavours in food; 10 increase the bioproduction of compounds; seven improve food profile/composition; two boost immunity/reduce toxicity in feed additives; five optimize food production processes, and one increases nitrogen-fixation as fertiliser. Only three identified GMMs have been subjected to an authorisation process by national or international authorities, and risk assessment studies are scarcely available. The findings of this horizon scan illustrate the growing worldwide adoption of NGTs in producing GMMs for application in the food and feed sectors.
  

• 
  1.

  Sánchez-Rodríguez C, Capitán-Moyano L, Malih N, Yáñez AM, Bennasar-Veny M, Velasco-Roldán O, Bulilete O, Llobera-Canaves J. Prevalence of musculoskeletal disorders among hotel housekeepers and cleaners: A systematic review with meta-analysis. Musculoskelet Sci Pract. 2023;69:102890.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Musculoskeletal disorders (MSD) are among the most frequent and costly occupational health problems with a rising prevalence globally. OBJECTIVE: This systematic review with meta-analysis was conducted to know and evaluate the prevalence of MSD by anatomic location among hotel housekeepers (HHs) and cleaners. METHODS: Electronic searches were conducted in PubMed, Web of Science, Scopus, Dialnet Plus, PEDro and Cochrane Database for Systematic Reviews using a search strategy to identify cross-sectional studies reporting on the prevalence of MSD in HHs or cleaners. The risk of bias was assessed with Joanna Briggs Institute tool for systematic reviews. A random-effects model was used in the meta-analysis. RESULTS: Nineteen studies were included in the systematic review, nine of them in the meta-analysis (n = 2299). The study sample sizes ranged from 24 to 1043 participants. The Standardized Nordic Musculoskeletal Questionnaire was the most common tool used to assess MSD among both HHs and cleaners (9/19 of the included studies). The three most affected anatomic locations were the low back 53.9% (95% CI: 43.3-64.6), shoulders 41.4% (95% CI: 27.1-55.8), and wrists/hands 40.1% (95% CI: 24.5-55.7). CONCLUSIONS: HHs and cleaners have a high prevalence of MSD. Low back pain is the most prevalent MSD among both HHs and cleaners affecting up to one of two people.

  @article{RN23,
  abstract = {BACKGROUND: Musculoskeletal disorders (MSD) are among the most frequent and costly occupational health problems with a rising prevalence globally. OBJECTIVE: This systematic review with meta-analysis was conducted to know and evaluate the prevalence of MSD by anatomic location among hotel housekeepers (HHs) and cleaners. METHODS: Electronic searches were conducted in PubMed, Web of Science, Scopus, Dialnet Plus, PEDro and Cochrane Database for Systematic Reviews using a search strategy to identify cross-sectional studies reporting on the prevalence of MSD in HHs or cleaners. The risk of bias was assessed with Joanna Briggs Institute tool for systematic reviews. A random-effects model was used in the meta-analysis. RESULTS: Nineteen studies were included in the systematic review, nine of them in the meta-analysis (n = 2299). The study sample sizes ranged from 24 to 1043 participants. The Standardized Nordic Musculoskeletal Questionnaire was the most common tool used to assess MSD among both HHs and cleaners (9/19 of the included studies). The three most affected anatomic locations were the low back 53.9% (95% CI: 43.3-64.6), shoulders 41.4% (95% CI: 27.1-55.8), and wrists/hands 40.1% (95% CI: 24.5-55.7). CONCLUSIONS: HHs and cleaners have a high prevalence of MSD. Low back pain is the most prevalent MSD among both HHs and cleaners affecting up to one of two people.},
  author = {Sánchez-Rodríguez, C. and Capitán-Moyano, L. and Malih, N. and Yáñez, A. M. and Bennasar-Veny, M. and Velasco-Roldán, O. and Bulilete, O. and Llobera-Canaves, J.},
  journal = {Musculoskelet Sci Pract},
  keywords = {grapp-caib},
  pages = 102890,
  title = {Prevalence of musculoskeletal disorders among hotel housekeepers and cleaners: A systematic review with meta-analysis},
  type = {Journal Article},
  volume = 69,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN23
  %A Sánchez-Rodríguez, C.
  %A Capitán-Moyano, L.
  %A Malih, N.
  %A Yáñez, A. M.
  %A Bennasar-Veny, M.
  %A Velasco-Roldán, O.
  %A Bulilete, O.
  %A Llobera-Canaves, J.
  %D 2023
  %J Musculoskelet Sci Pract
  %P 102890
  %R 10.1016/j.msksp.2023.102890
  %T Prevalence of musculoskeletal disorders among hotel housekeepers and cleaners: A systematic review with meta-analysis
  %V 69
  %X BACKGROUND: Musculoskeletal disorders (MSD) are among the most frequent and costly occupational health problems with a rising prevalence globally. OBJECTIVE: This systematic review with meta-analysis was conducted to know and evaluate the prevalence of MSD by anatomic location among hotel housekeepers (HHs) and cleaners. METHODS: Electronic searches were conducted in PubMed, Web of Science, Scopus, Dialnet Plus, PEDro and Cochrane Database for Systematic Reviews using a search strategy to identify cross-sectional studies reporting on the prevalence of MSD in HHs or cleaners. The risk of bias was assessed with Joanna Briggs Institute tool for systematic reviews. A random-effects model was used in the meta-analysis. RESULTS: Nineteen studies were included in the systematic review, nine of them in the meta-analysis (n = 2299). The study sample sizes ranged from 24 to 1043 participants. The Standardized Nordic Musculoskeletal Questionnaire was the most common tool used to assess MSD among both HHs and cleaners (9/19 of the included studies). The three most affected anatomic locations were the low back 53.9% (95% CI: 43.3-64.6), shoulders 41.4% (95% CI: 27.1-55.8), and wrists/hands 40.1% (95% CI: 24.5-55.7). CONCLUSIONS: HHs and cleaners have a high prevalence of MSD. Low back pain is the most prevalent MSD among both HHs and cleaners affecting up to one of two people.
  

• 
  1.

  Bennasar-Veny M, Malih N, Galmes-Panades AM, Hernandez-Bermudez IC, Garcia-Coll N, Ricci-Cabello I, Yañez AM. Effect of physical activity and different exercise modalities on glycemic control in people with prediabetes: a systematic review and meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne). 2023;14:1233312.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Numerous studies have shown the beneficial effects of exercise on glycemic control in people with prediabetes. However, the most effective exercise modality for improving glycemic control remains unclear. We aimed to assess which exercise training modality is most effective in improving glycemic control in a population with prediabetes. METHODS: We conducted searches in Pubmed/MEDLINE, EMBASE, SPORTDiscus, Web of Science, PEDro, BVS, and the Cochrane Library from inception to June 2022. Included studies reported fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and 2-hour postprandial (2hPP) levels and implemented an exercise program lasting at least 12 weeks in adults with prediabetes. We performed a direct meta-analysis using a random-effects model and a network meta-analysis. Cochran's Q statistic and the inconsistency I(2) test were used to assess the heterogenicity between studies. RESULTS: Twenty trials were included, with 15 trials (comprising 775 participants with prediabetes) combined in the meta-analysis, and 13 in the network meta-analysis. The meta-analysis results did not show a statistically significant reduction in fasting plasma glucose (FPG) after aerobic training (AT) intervention compared to a control group (mean (95%CI) difference = -5.18 (-13.48; 3.12) mg/dL, Z=1.22, p=0.22). However, a difference of -7.25 (-13.79; -0.71) mg/dL, p=0.03, in FPG after interval training (IT) intervention was detected compared to a control group. After resistance training (RT) intervention, FPG was significantly lower -6.71 (-12.65,-0.77) mg/dL, Z=2.21, p=0.03, and HbA1c by -0.13 (-0.55, 0.29), p=0.54, compared to the control group. The impact of RT compared to no intervention on 2hPP was not statistically significant (p=0.26). The network meta-analysis did not show statistical significance. Most of the studies presented an unclear risk of bias, and a low and very low-quality of evidence. According to the GRADE criteria, the strength of the body of evidence was low. CONCLUSION: Resistance training and IT had demonstrated benefits on glycemic indices, especially on FPG, in a population with prediabetes. Further studies with larger sample sizes and a more robust methodology that compare different types of exercise modalities, frequencies, and durations, are needed to establish a beneficial exercise intervention. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=370688, identifier CRD42022370688.

  @article{RN125,
  abstract = {BACKGROUND: Numerous studies have shown the beneficial effects of exercise on glycemic control in people with prediabetes. However, the most effective exercise modality for improving glycemic control remains unclear. We aimed to assess which exercise training modality is most effective in improving glycemic control in a population with prediabetes. METHODS: We conducted searches in Pubmed/MEDLINE, EMBASE, SPORTDiscus, Web of Science, PEDro, BVS, and the Cochrane Library from inception to June 2022. Included studies reported fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and 2-hour postprandial (2hPP) levels and implemented an exercise program lasting at least 12 weeks in adults with prediabetes. We performed a direct meta-analysis using a random-effects model and a network meta-analysis. Cochran's Q statistic and the inconsistency I(2) test were used to assess the heterogenicity between studies. RESULTS: Twenty trials were included, with 15 trials (comprising 775 participants with prediabetes) combined in the meta-analysis, and 13 in the network meta-analysis. The meta-analysis results did not show a statistically significant reduction in fasting plasma glucose (FPG) after aerobic training (AT) intervention compared to a control group (mean (95%CI) difference = -5.18 (-13.48; 3.12) mg/dL, Z=1.22, p=0.22). However, a difference of -7.25 (-13.79; -0.71) mg/dL, p=0.03, in FPG after interval training (IT) intervention was detected compared to a control group. After resistance training (RT) intervention, FPG was significantly lower -6.71 (-12.65,-0.77) mg/dL, Z=2.21, p=0.03, and HbA1c by -0.13 (-0.55, 0.29), p=0.54, compared to the control group. The impact of RT compared to no intervention on 2hPP was not statistically significant (p=0.26). The network meta-analysis did not show statistical significance. Most of the studies presented an unclear risk of bias, and a low and very low-quality of evidence. According to the GRADE criteria, the strength of the body of evidence was low. CONCLUSION: Resistance training and IT had demonstrated benefits on glycemic indices, especially on FPG, in a population with prediabetes. Further studies with larger sample sizes and a more robust methodology that compare different types of exercise modalities, frequencies, and durations, are needed to establish a beneficial exercise intervention. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=370688, identifier CRD42022370688.},
  author = {Bennasar-Veny, M. and Malih, N. and Galmes-Panades, A. M. and Hernandez-Bermudez, I. C. and Garcia-Coll, N. and Ricci-Cabello, I. and Yañez, A. M.},
  journal = {Front Endocrinol (Lausanne)},
  keywords = {evisap grapp-caib},
  pages = 1233312,
  title = {Effect of physical activity and different exercise modalities on glycemic control in people with prediabetes: a systematic review and meta-analysis of randomized controlled trials},
  type = {Journal Article},
  volume = 14,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN125
  %A Bennasar-Veny, M.
  %A Malih, N.
  %A Galmes-Panades, A. M.
  %A Hernandez-Bermudez, I. C.
  %A Garcia-Coll, N.
  %A Ricci-Cabello, I.
  %A Yañez, A. M.
  %D 2023
  %J Front Endocrinol (Lausanne)
  %P 1233312
  %R 10.3389/fendo.2023.1233312
  %T Effect of physical activity and different exercise modalities on glycemic control in people with prediabetes: a systematic review and meta-analysis of randomized controlled trials
  %V 14
  %X BACKGROUND: Numerous studies have shown the beneficial effects of exercise on glycemic control in people with prediabetes. However, the most effective exercise modality for improving glycemic control remains unclear. We aimed to assess which exercise training modality is most effective in improving glycemic control in a population with prediabetes. METHODS: We conducted searches in Pubmed/MEDLINE, EMBASE, SPORTDiscus, Web of Science, PEDro, BVS, and the Cochrane Library from inception to June 2022. Included studies reported fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and 2-hour postprandial (2hPP) levels and implemented an exercise program lasting at least 12 weeks in adults with prediabetes. We performed a direct meta-analysis using a random-effects model and a network meta-analysis. Cochran's Q statistic and the inconsistency I(2) test were used to assess the heterogenicity between studies. RESULTS: Twenty trials were included, with 15 trials (comprising 775 participants with prediabetes) combined in the meta-analysis, and 13 in the network meta-analysis. The meta-analysis results did not show a statistically significant reduction in fasting plasma glucose (FPG) after aerobic training (AT) intervention compared to a control group (mean (95%CI) difference = -5.18 (-13.48; 3.12) mg/dL, Z=1.22, p=0.22). However, a difference of -7.25 (-13.79; -0.71) mg/dL, p=0.03, in FPG after interval training (IT) intervention was detected compared to a control group. After resistance training (RT) intervention, FPG was significantly lower -6.71 (-12.65,-0.77) mg/dL, Z=2.21, p=0.03, and HbA1c by -0.13 (-0.55, 0.29), p=0.54, compared to the control group. The impact of RT compared to no intervention on 2hPP was not statistically significant (p=0.26). The network meta-analysis did not show statistical significance. Most of the studies presented an unclear risk of bias, and a low and very low-quality of evidence. According to the GRADE criteria, the strength of the body of evidence was low. CONCLUSION: Resistance training and IT had demonstrated benefits on glycemic indices, especially on FPG, in a population with prediabetes. Further studies with larger sample sizes and a more robust methodology that compare different types of exercise modalities, frequencies, and durations, are needed to establish a beneficial exercise intervention. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=370688, identifier CRD42022370688.
  

• 
  1.

  Zamanillo-Campos R, Fiol-DeRoque MA, Serrano-Ripoll MJ, Mira-Martínez S, Llobera-Canaves J, Taltavull-Aparicio JM, Leiva-Rus A, Ripoll-Amengual J, Angullo-Martínez E, Socias-Buades IM, Masmiquel-Comas L, Konieczna J, Zaforteza-Dezcallar M, Boronat-Moreiro MA, Gervilla-García E, Ricci-Cabello I. DiabeText, a mobile health intervention to support medication taking and healthy lifestyle in adults with type 2 diabetes: Study protocol for a randomized controlled trial. Contemp Clin Trials. 2023;136:107399.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  AIM: To evaluate the effectiveness of DiabeText, a low-intensity, multifaceted, mobile health (mHealth) intervention to support medication taking and lifestyle change targeted to people with type 2 diabetes (T2D). DESIGN: Phase III, 12-months, two-arm (1:1 allocation ratio), randomized parallel-group trial. METHODS: We will recruit 740 adults with glycated hemoglobin (A1c) >8% (>64 mmol/mol) and with at least one prescription of a non-insulin antidiabetic drug. They will be allocated to a control (usual care) group or an intervention (DiabeText messaging intervention) group. The primary outcome measure will be A1c at 12 months follow-up. Secondary outcomes will include medication possession ratio and behavioral and psychological outcomes. DISCUSSION: Recent trials suggest that digital health interventions can effectively support diabetes self-management improving T2D control and reducing important T2D complications. In Spain this type of interventions is understudied. IMPACT: This trial will strengthen the evidence base of the impact of mHealth interventions to support diabetes self-management. If effective, DiabeText may offer a low-cost and highly scalable strategy to improve health at the population level in a sustainable way. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT05006872; Official Title: Supporting People with Type 2 Diabetes in Effective Use of their Medicine Through a System Comprising Mobile Health Technology Integrated with Clinical Care.

  @article{RN43,
  abstract = {AIM: To evaluate the effectiveness of DiabeText, a low-intensity, multifaceted, mobile health (mHealth) intervention to support medication taking and lifestyle change targeted to people with type 2 diabetes (T2D). DESIGN: Phase III, 12-months, two-arm (1:1 allocation ratio), randomized parallel-group trial. METHODS: We will recruit 740 adults with glycated hemoglobin (A1c) >8% (>64 mmol/mol) and with at least one prescription of a non-insulin antidiabetic drug. They will be allocated to a control (usual care) group or an intervention (DiabeText messaging intervention) group. The primary outcome measure will be A1c at 12 months follow-up. Secondary outcomes will include medication possession ratio and behavioral and psychological outcomes. DISCUSSION: Recent trials suggest that digital health interventions can effectively support diabetes self-management improving T2D control and reducing important T2D complications. In Spain this type of interventions is understudied. IMPACT: This trial will strengthen the evidence base of the impact of mHealth interventions to support diabetes self-management. If effective, DiabeText may offer a low-cost and highly scalable strategy to improve health at the population level in a sustainable way. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT05006872; Official Title: Supporting People with Type 2 Diabetes in Effective Use of their Medicine Through a System Comprising Mobile Health Technology Integrated with Clinical Care.},
  author = {Zamanillo-Campos, R. and Fiol-DeRoque, M. A. and Serrano-Ripoll, M. J. and Mira-Martínez, S. and Llobera-Canaves, J. and Taltavull-Aparicio, J. M. and Leiva-Rus, A. and Ripoll-Amengual, J. and Angullo-Martínez, E. and Socias-Buades, I. M. and Masmiquel-Comas, L. and Konieczna, J. and Zaforteza-Dezcallar, M. and Boronat-Moreiro, M. A. and Gervilla-García, E. and Ricci-Cabello, I.},
  journal = {Contemp Clin Trials},
  keywords = {evisap grapp-caib},
  pages = 107399,
  title = {DiabeText, a mobile health intervention to support medication taking and healthy lifestyle in adults with type 2 diabetes: Study protocol for a randomized controlled trial},
  type = {Journal Article},
  volume = 136,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN43
  %A Zamanillo-Campos, R.
  %A Fiol-DeRoque, M. A.
  %A Serrano-Ripoll, M. J.
  %A Mira-Martínez, S.
  %A Llobera-Canaves, J.
  %A Taltavull-Aparicio, J. M.
  %A Leiva-Rus, A.
  %A Ripoll-Amengual, J.
  %A Angullo-Martínez, E.
  %A Socias-Buades, I. M.
  %A Masmiquel-Comas, L.
  %A Konieczna, J.
  %A Zaforteza-Dezcallar, M.
  %A Boronat-Moreiro, M. A.
  %A Gervilla-García, E.
  %A Ricci-Cabello, I.
  %D 2023
  %J Contemp Clin Trials
  %P 107399
  %R 10.1016/j.cct.2023.107399
  %T DiabeText, a mobile health intervention to support medication taking and healthy lifestyle in adults with type 2 diabetes: Study protocol for a randomized controlled trial
  %V 136
  %X AIM: To evaluate the effectiveness of DiabeText, a low-intensity, multifaceted, mobile health (mHealth) intervention to support medication taking and lifestyle change targeted to people with type 2 diabetes (T2D). DESIGN: Phase III, 12-months, two-arm (1:1 allocation ratio), randomized parallel-group trial. METHODS: We will recruit 740 adults with glycated hemoglobin (A1c) >8% (>64 mmol/mol) and with at least one prescription of a non-insulin antidiabetic drug. They will be allocated to a control (usual care) group or an intervention (DiabeText messaging intervention) group. The primary outcome measure will be A1c at 12 months follow-up. Secondary outcomes will include medication possession ratio and behavioral and psychological outcomes. DISCUSSION: Recent trials suggest that digital health interventions can effectively support diabetes self-management improving T2D control and reducing important T2D complications. In Spain this type of interventions is understudied. IMPACT: This trial will strengthen the evidence base of the impact of mHealth interventions to support diabetes self-management. If effective, DiabeText may offer a low-cost and highly scalable strategy to improve health at the population level in a sustainable way. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT05006872; Official Title: Supporting People with Type 2 Diabetes in Effective Use of their Medicine Through a System Comprising Mobile Health Technology Integrated with Clinical Care.
  

• 
  1.

  Riera-Serra P, Navarra-Ventura G, Castro A, Gili M, Salazar-Cedillo A, Ricci-Cabello I, Roldán-Espínola L, Coronado-Simsic V, García-Toro M, Gómez-Juanes R, Roca M. Clinical predictors of suicidal ideation, suicide attempts and suicide death in depressive disorder: a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci. 2023;.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  AIM: To evaluate the effectiveness of DiabeText, a low-intensity, multifaceted, mobile health (mHealth) intervention to support medication taking and lifestyle change targeted to people with type 2 diabetes (T2D). DESIGN: Phase III, 12-months, two-arm (1:1 allocation ratio), randomized parallel-group trial. METHODS: We will recruit 740 adults with glycated hemoglobin (A1c) >8% (>64 mmol/mol) and with at least one prescription of a non-insulin antidiabetic drug. They will be allocated to a control (usual care) group or an intervention (DiabeText messaging intervention) group. The primary outcome measure will be A1c at 12 months follow-up. Secondary outcomes will include medication possession ratio and behavioral and psychological outcomes. DISCUSSION: Recent trials suggest that digital health interventions can effectively support diabetes self-management improving T2D control and reducing important T2D complications. In Spain this type of interventions is understudied. IMPACT: This trial will strengthen the evidence base of the impact of mHealth interventions to support diabetes self-management. If effective, DiabeText may offer a low-cost and highly scalable strategy to improve health at the population level in a sustainable way. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT05006872; Official Title: Supporting People with Type 2 Diabetes in Effective Use of their Medicine Through a System Comprising Mobile Health Technology Integrated with Clinical Care.

  @article{RN42,
  abstract = {AIM: To evaluate the effectiveness of DiabeText, a low-intensity, multifaceted, mobile health (mHealth) intervention to support medication taking and lifestyle change targeted to people with type 2 diabetes (T2D). DESIGN: Phase III, 12-months, two-arm (1:1 allocation ratio), randomized parallel-group trial. METHODS: We will recruit 740 adults with glycated hemoglobin (A1c) >8% (>64 mmol/mol) and with at least one prescription of a non-insulin antidiabetic drug. They will be allocated to a control (usual care) group or an intervention (DiabeText messaging intervention) group. The primary outcome measure will be A1c at 12 months follow-up. Secondary outcomes will include medication possession ratio and behavioral and psychological outcomes. DISCUSSION: Recent trials suggest that digital health interventions can effectively support diabetes self-management improving T2D control and reducing important T2D complications. In Spain this type of interventions is understudied. IMPACT: This trial will strengthen the evidence base of the impact of mHealth interventions to support diabetes self-management. If effective, DiabeText may offer a low-cost and highly scalable strategy to improve health at the population level in a sustainable way. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT05006872; Official Title: Supporting People with Type 2 Diabetes in Effective Use of their Medicine Through a System Comprising Mobile Health Technology Integrated with Clinical Care.},
  author = {Riera-Serra, P. and Navarra-Ventura, G. and Castro, A. and Gili, M. and Salazar-Cedillo, A. and Ricci-Cabello, I. and Roldán-Espínola, L. and Coronado-Simsic, V. and García-Toro, M. and Gómez-Juanes, R. and Roca, M.},
  journal = {Eur Arch Psychiatry Clin Neurosci},
  keywords = {evisap grapp-caib},
  title = {Clinical predictors of suicidal ideation, suicide attempts and suicide death in depressive disorder: a systematic review and meta-analysis},
  type = {Journal Article},
  year = 2023
  }
  

  %0 Journal Article
  %1 RN42
  %A Riera-Serra, P.
  %A Navarra-Ventura, G.
  %A Castro, A.
  %A Gili, M.
  %A Salazar-Cedillo, A.
  %A Ricci-Cabello, I.
  %A Roldán-Espínola, L.
  %A Coronado-Simsic, V.
  %A García-Toro, M.
  %A Gómez-Juanes, R.
  %A Roca, M.
  %D 2023
  %J Eur Arch Psychiatry Clin Neurosci
  %R 10.1007/s00406-023-01716-5
  %T Clinical predictors of suicidal ideation, suicide attempts and suicide death in depressive disorder: a systematic review and meta-analysis
  %X AIM: To evaluate the effectiveness of DiabeText, a low-intensity, multifaceted, mobile health (mHealth) intervention to support medication taking and lifestyle change targeted to people with type 2 diabetes (T2D). DESIGN: Phase III, 12-months, two-arm (1:1 allocation ratio), randomized parallel-group trial. METHODS: We will recruit 740 adults with glycated hemoglobin (A1c) >8% (>64 mmol/mol) and with at least one prescription of a non-insulin antidiabetic drug. They will be allocated to a control (usual care) group or an intervention (DiabeText messaging intervention) group. The primary outcome measure will be A1c at 12 months follow-up. Secondary outcomes will include medication possession ratio and behavioral and psychological outcomes. DISCUSSION: Recent trials suggest that digital health interventions can effectively support diabetes self-management improving T2D control and reducing important T2D complications. In Spain this type of interventions is understudied. IMPACT: This trial will strengthen the evidence base of the impact of mHealth interventions to support diabetes self-management. If effective, DiabeText may offer a low-cost and highly scalable strategy to improve health at the population level in a sustainable way. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT05006872; Official Title: Supporting People with Type 2 Diabetes in Effective Use of their Medicine Through a System Comprising Mobile Health Technology Integrated with Clinical Care.
  

• 
  1.

  Zamanillo-Campos R, Zaforteza Dezcallar M, Boronat Moreiro MA, Leiva Rus A, Ripoll Amengual J, Konieczna J, Fiol deRoque MA, Ricci-Cabello I. Non-adherence to non-insulin glucose-lowering drugs: Prevalence, predictors and impact on glycemic control and insulin initiation. A longitudinal cohort study in a large primary care database in Spain. Eur J Gen Pract. 2023;29(1):2268838.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: A better understanding of patient non-adherence to type 2 diabetes medication is needed to design effective interventions to address this issue. OBJECTIVES: (1) To estimate the prevalence of non-adherence to diabetes medication; (2) to examine its impact on glycemic control and insulin initiation; (3) to develop and validate a prediction model of non-adherence. METHODS: We conducted a longitudinal cohort study based on data from electronic health records. We included adult patients registered within the Health Service of the Balearic Islands (Spain) starting a new prescription of a non-insulin glucose-lowering drug between January 2016 and December 2018. We calculated non-adherence at 12 months follow-up, defined as medication possession ratio (MPR) ≤ 80%. We fitted multivariable regression models to examine the association between non-adherence and glycemic control and insulin initiation and identified predictors of non-adherence. RESULTS: Of 18,119 patients identified, after 12 months follow-up, 5,740 (31.68%) were non-adherent. Compared with non-adherent, adherent patients presented lower HbA1c levels (mean difference = -0.32%; 95%CI = -0.38%; -0.27%) and were less likely to initiate insulin (aOR = 0.77; 95%CI = 0.63; 0.94). A predictive model explained 22.3% of the variation and presented a satisfactory performance (AUC = 0.721; Brier score = 0.177). The most important predictors of non-adherence were: non-Spanish nationality, currently working, low adherence to previous drugs, taking biguanides, smoker and absence of hypertension. CONCLUSION: Around one-third of the patients do not adhere to their non-insulin glucose-lowering drugs. More research is needed to optimise the performance of the predicting model before considering its implementation in routine clinical practice.

  @article{RN138,
  abstract = {BACKGROUND: A better understanding of patient non-adherence to type 2 diabetes medication is needed to design effective interventions to address this issue. OBJECTIVES: (1) To estimate the prevalence of non-adherence to diabetes medication; (2) to examine its impact on glycemic control and insulin initiation; (3) to develop and validate a prediction model of non-adherence. METHODS: We conducted a longitudinal cohort study based on data from electronic health records. We included adult patients registered within the Health Service of the Balearic Islands (Spain) starting a new prescription of a non-insulin glucose-lowering drug between January 2016 and December 2018. We calculated non-adherence at 12 months follow-up, defined as medication possession ratio (MPR) ≤ 80%. We fitted multivariable regression models to examine the association between non-adherence and glycemic control and insulin initiation and identified predictors of non-adherence. RESULTS: Of 18,119 patients identified, after 12 months follow-up, 5,740 (31.68%) were non-adherent. Compared with non-adherent, adherent patients presented lower HbA1c levels (mean difference = -0.32%; 95%CI = -0.38%; -0.27%) and were less likely to initiate insulin (aOR = 0.77; 95%CI = 0.63; 0.94). A predictive model explained 22.3% of the variation and presented a satisfactory performance (AUC = 0.721; Brier score = 0.177). The most important predictors of non-adherence were: non-Spanish nationality, currently working, low adherence to previous drugs, taking biguanides, smoker and absence of hypertension. CONCLUSION: Around one-third of the patients do not adhere to their non-insulin glucose-lowering drugs. More research is needed to optimise the performance of the predicting model before considering its implementation in routine clinical practice.},
  author = {Zamanillo-Campos, R. and Zaforteza Dezcallar, M. and Boronat Moreiro, M. A. and Leiva Rus, A. and Ripoll Amengual, J. and Konieczna, J. and Fiol deRoque, M. A. and Ricci-Cabello, I.},
  journal = {Eur J Gen Pract},
  keywords = {evisap grapp-caib},
  number = 1,
  pages = 2268838,
  title = {Non-adherence to non-insulin glucose-lowering drugs: Prevalence, predictors and impact on glycemic control and insulin initiation. A longitudinal cohort study in a large primary care database in Spain},
  type = {Journal Article},
  volume = 29,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN138
  %A Zamanillo-Campos, R.
  %A Zaforteza Dezcallar, M.
  %A Boronat Moreiro, M. A.
  %A Leiva Rus, A.
  %A Ripoll Amengual, J.
  %A Konieczna, J.
  %A Fiol deRoque, M. A.
  %A Ricci-Cabello, I.
  %D 2023
  %J Eur J Gen Pract
  %N 1
  %P 2268838
  %R 10.1080/13814788.2023.2268838
  %T Non-adherence to non-insulin glucose-lowering drugs: Prevalence, predictors and impact on glycemic control and insulin initiation. A longitudinal cohort study in a large primary care database in Spain
  %V 29
  %X BACKGROUND: A better understanding of patient non-adherence to type 2 diabetes medication is needed to design effective interventions to address this issue. OBJECTIVES: (1) To estimate the prevalence of non-adherence to diabetes medication; (2) to examine its impact on glycemic control and insulin initiation; (3) to develop and validate a prediction model of non-adherence. METHODS: We conducted a longitudinal cohort study based on data from electronic health records. We included adult patients registered within the Health Service of the Balearic Islands (Spain) starting a new prescription of a non-insulin glucose-lowering drug between January 2016 and December 2018. We calculated non-adherence at 12 months follow-up, defined as medication possession ratio (MPR) ≤ 80%. We fitted multivariable regression models to examine the association between non-adherence and glycemic control and insulin initiation and identified predictors of non-adherence. RESULTS: Of 18,119 patients identified, after 12 months follow-up, 5,740 (31.68%) were non-adherent. Compared with non-adherent, adherent patients presented lower HbA1c levels (mean difference = -0.32%; 95%CI = -0.38%; -0.27%) and were less likely to initiate insulin (aOR = 0.77; 95%CI = 0.63; 0.94). A predictive model explained 22.3% of the variation and presented a satisfactory performance (AUC = 0.721; Brier score = 0.177). The most important predictors of non-adherence were: non-Spanish nationality, currently working, low adherence to previous drugs, taking biguanides, smoker and absence of hypertension. CONCLUSION: Around one-third of the patients do not adhere to their non-insulin glucose-lowering drugs. More research is needed to optimise the performance of the predicting model before considering its implementation in routine clinical practice.
  

• 
  1.

  Koskela TH, Esteva M, Mangione M, Contreras Martos S, Hajdarevic S, Högberg C, Marzo-Castillejo M, Sawicka-Powierza J, Siliņa V, Harris M, Petek D. What would primary care practitioners do differently after a delayed cancer diagnosis? Learning lessons from their experiences. Scand J Prim Health Care. 2023;:1-9.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  OBJECTIVE: Diagnosis of cancer is challenging in primary care due to the low incidence of cancer cases in primary care practice. A prolonged diagnostic interval may be due to doctor, patient or system factors, or may be due to the characteristics of the cancer itself. The objective of this study was to learn from Primary Care Physicians' (PCP) experiences of incidents when they had failed to think of, or act on, a cancer diagnosis. DESIGN: A qualitative, online survey eliciting PCP narratives. Thematic analysis was used to analyse the data. SETTING AND SUBJECTS: A primary care study, with narratives from 159 PCPs in 23 European countries. MAIN OUTCOME MEASURES: PCPs' narratives on the question 'If you saw this patient with cancer presenting in the same way today, what would you do differently? RESULTS: The main themes identified were: thinking broadly; improvement in communication and clinical management; use of other available resources and 'I wouldn't do anything differently'. CONCLUSION (IMPLICATIONS): To achieve more timely cancer diagnosis, PCPs need to provide a long-term, holistic and active approach with effective communication, and to ensure shared decision-making, follow-up and continuing re-assessment of the patients' clinical conditions. Diagnosing cancer in primary care is challenging due to the low incidence of cancer in practice and the multiple confounding factors that are involved in the diagnostic process.The need to think broadly, make improvements in communication and clinical management, and use other available resources were the main themes from Primary Care Physicians’ (PCPs’) narratives about their learning experiences from missed or late cancer diagnoses.A long-term, holistic and active approach with effective communication, follow-up and continuing re-assessment of the patients’ clinical conditions was another theme for making improvements.Some PCPs, on reflection, would not have done anything differently.

  @article{RN26,
  abstract = {OBJECTIVE: Diagnosis of cancer is challenging in primary care due to the low incidence of cancer cases in primary care practice. A prolonged diagnostic interval may be due to doctor, patient or system factors, or may be due to the characteristics of the cancer itself. The objective of this study was to learn from Primary Care Physicians' (PCP) experiences of incidents when they had failed to think of, or act on, a cancer diagnosis. DESIGN: A qualitative, online survey eliciting PCP narratives. Thematic analysis was used to analyse the data. SETTING AND SUBJECTS: A primary care study, with narratives from 159 PCPs in 23 European countries. MAIN OUTCOME MEASURES: PCPs' narratives on the question 'If you saw this patient with cancer presenting in the same way today, what would you do differently? RESULTS: The main themes identified were: thinking broadly; improvement in communication and clinical management; use of other available resources and 'I wouldn't do anything differently'. CONCLUSION (IMPLICATIONS): To achieve more timely cancer diagnosis, PCPs need to provide a long-term, holistic and active approach with effective communication, and to ensure shared decision-making, follow-up and continuing re-assessment of the patients' clinical conditions. Diagnosing cancer in primary care is challenging due to the low incidence of cancer in practice and the multiple confounding factors that are involved in the diagnostic process.The need to think broadly, make improvements in communication and clinical management, and use other available resources were the main themes from Primary Care Physicians’ (PCPs’) narratives about their learning experiences from missed or late cancer diagnoses.A long-term, holistic and active approach with effective communication, follow-up and continuing re-assessment of the patients’ clinical conditions was another theme for making improvements.Some PCPs, on reflection, would not have done anything differently.},
  author = {Koskela, T. H. and Esteva, M. and Mangione, M. and Contreras Martos, S. and Hajdarevic, S. and Högberg, C. and Marzo-Castillejo, M. and Sawicka-Powierza, J. and Siliņa, V. and Harris, M. and Petek, D.},
  journal = {Scand J Prim Health Care},
  keywords = {grapp-caib},
  pages = {1-9},
  title = {What would primary care practitioners do differently after a delayed cancer diagnosis? Learning lessons from their experiences},
  type = {Journal Article},
  year = 2023
  }
  

  %0 Journal Article
  %1 RN26
  %A Koskela, T. H.
  %A Esteva, M.
  %A Mangione, M.
  %A Contreras Martos, S.
  %A Hajdarevic, S.
  %A Högberg, C.
  %A Marzo-Castillejo, M.
  %A Sawicka-Powierza, J.
  %A Siliņa, V.
  %A Harris, M.
  %A Petek, D.
  %D 2023
  %J Scand J Prim Health Care
  %P 1-9
  %R 10.1080/02813432.2023.2296117
  %T What would primary care practitioners do differently after a delayed cancer diagnosis? Learning lessons from their experiences
  %X OBJECTIVE: Diagnosis of cancer is challenging in primary care due to the low incidence of cancer cases in primary care practice. A prolonged diagnostic interval may be due to doctor, patient or system factors, or may be due to the characteristics of the cancer itself. The objective of this study was to learn from Primary Care Physicians' (PCP) experiences of incidents when they had failed to think of, or act on, a cancer diagnosis. DESIGN: A qualitative, online survey eliciting PCP narratives. Thematic analysis was used to analyse the data. SETTING AND SUBJECTS: A primary care study, with narratives from 159 PCPs in 23 European countries. MAIN OUTCOME MEASURES: PCPs' narratives on the question 'If you saw this patient with cancer presenting in the same way today, what would you do differently? RESULTS: The main themes identified were: thinking broadly; improvement in communication and clinical management; use of other available resources and 'I wouldn't do anything differently'. CONCLUSION (IMPLICATIONS): To achieve more timely cancer diagnosis, PCPs need to provide a long-term, holistic and active approach with effective communication, and to ensure shared decision-making, follow-up and continuing re-assessment of the patients' clinical conditions. Diagnosing cancer in primary care is challenging due to the low incidence of cancer in practice and the multiple confounding factors that are involved in the diagnostic process.The need to think broadly, make improvements in communication and clinical management, and use other available resources were the main themes from Primary Care Physicians’ (PCPs’) narratives about their learning experiences from missed or late cancer diagnoses.A long-term, holistic and active approach with effective communication, follow-up and continuing re-assessment of the patients’ clinical conditions was another theme for making improvements.Some PCPs, on reflection, would not have done anything differently.
  

• 
  1.

  Neves AL, Esteva M, Hoffman R, Harris M. Primary care practitioners’ priorities for improving the timeliness of cancer diagnosis in primary care: a European cluster-based analysis. BMC Health Serv Res. 2023;23(1):997.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Diagnosing cancer at an early stage increases the likelihood of survival, and more advanced cancers are more difficult to treat successfully. Primary care practitioners (PCPs) play a key role in timely diagnosis of cancer. PCPs' knowledge of their own patient populations and health systems could help improve the planning of more effective approaches to earlier cancer recognition and referral. How PCPs act when faced with patients who may have cancer is likely to depend on how their health systems are organised, and this may be one explanation for the wide variation on cancer survival rates across Europe. OBJECTIVES: To identify and characterise clusters of countries whose PCPs perceive the same factors as being important in improving the timeliness of cancer diagnosis. METHODS: A cluster analysis of qualitative data from an online survey was carried out. PCPs answered an open-ended survey question on how the speed of diagnosis of cancer in primary care could be improved. Following coding and thematic analysis, we identified the number of times per country that an item in a theme was mentioned. k-means clustering identified clusters of countries whose PCPs perceived the same themes as most important. Post-hoc testing explored differences between these clusters. SETTING: Twenty-five primary care centres in 20 European countries. Each centre was asked to recruit at least 50 participants. PARTICIPANTS: Primary care practitioners of each country. RESULTS: In all, 1,351 PCPs gave free-text answers. We identified eighteen themes organising the content of the responses. Based on the frequency of the themes, k-means clustering identified three groups of countries. There were significant differences between clusters regarding the importance of: access to tests (p = 0.010); access to specialists (p = 0.014), screening (p < 0.001); and finances, quotas & limits (p < 0.001). CONCLUSIONS: Our study identified three distinct clusters of European countries within which PCPs had similar views on the factors that would improve the timeliness of cancer diagnosis. Further work is needed to understand what it is about the clusters that have produced these patterns, allowing healthcare systems to share best practice and to reduce disparities.

  @article{RN51,
  abstract = {BACKGROUND: Diagnosing cancer at an early stage increases the likelihood of survival, and more advanced cancers are more difficult to treat successfully. Primary care practitioners (PCPs) play a key role in timely diagnosis of cancer. PCPs' knowledge of their own patient populations and health systems could help improve the planning of more effective approaches to earlier cancer recognition and referral. How PCPs act when faced with patients who may have cancer is likely to depend on how their health systems are organised, and this may be one explanation for the wide variation on cancer survival rates across Europe. OBJECTIVES: To identify and characterise clusters of countries whose PCPs perceive the same factors as being important in improving the timeliness of cancer diagnosis. METHODS: A cluster analysis of qualitative data from an online survey was carried out. PCPs answered an open-ended survey question on how the speed of diagnosis of cancer in primary care could be improved. Following coding and thematic analysis, we identified the number of times per country that an item in a theme was mentioned. k-means clustering identified clusters of countries whose PCPs perceived the same themes as most important. Post-hoc testing explored differences between these clusters. SETTING: Twenty-five primary care centres in 20 European countries. Each centre was asked to recruit at least 50 participants. PARTICIPANTS: Primary care practitioners of each country. RESULTS: In all, 1,351 PCPs gave free-text answers. We identified eighteen themes organising the content of the responses. Based on the frequency of the themes, k-means clustering identified three groups of countries. There were significant differences between clusters regarding the importance of: access to tests (p = 0.010); access to specialists (p = 0.014), screening (p < 0.001); and finances, quotas & limits (p < 0.001). CONCLUSIONS: Our study identified three distinct clusters of European countries within which PCPs had similar views on the factors that would improve the timeliness of cancer diagnosis. Further work is needed to understand what it is about the clusters that have produced these patterns, allowing healthcare systems to share best practice and to reduce disparities.},
  author = {Neves, A. L. and Esteva, M. and Hoffman, R. and Harris, M.},
  journal = {BMC Health Serv Res},
  keywords = {grapp-caib},
  number = 1,
  pages = 997,
  title = {Primary care practitioners' priorities for improving the timeliness of cancer diagnosis in primary care: a European cluster-based analysis},
  type = {Journal Article},
  volume = 23,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN51
  %A Neves, A. L.
  %A Esteva, M.
  %A Hoffman, R.
  %A Harris, M.
  %D 2023
  %J BMC Health Serv Res
  %N 1
  %P 997
  %R 10.1186/s12913-023-09891-w
  %T Primary care practitioners' priorities for improving the timeliness of cancer diagnosis in primary care: a European cluster-based analysis
  %V 23
  %X BACKGROUND: Diagnosing cancer at an early stage increases the likelihood of survival, and more advanced cancers are more difficult to treat successfully. Primary care practitioners (PCPs) play a key role in timely diagnosis of cancer. PCPs' knowledge of their own patient populations and health systems could help improve the planning of more effective approaches to earlier cancer recognition and referral. How PCPs act when faced with patients who may have cancer is likely to depend on how their health systems are organised, and this may be one explanation for the wide variation on cancer survival rates across Europe. OBJECTIVES: To identify and characterise clusters of countries whose PCPs perceive the same factors as being important in improving the timeliness of cancer diagnosis. METHODS: A cluster analysis of qualitative data from an online survey was carried out. PCPs answered an open-ended survey question on how the speed of diagnosis of cancer in primary care could be improved. Following coding and thematic analysis, we identified the number of times per country that an item in a theme was mentioned. k-means clustering identified clusters of countries whose PCPs perceived the same themes as most important. Post-hoc testing explored differences between these clusters. SETTING: Twenty-five primary care centres in 20 European countries. Each centre was asked to recruit at least 50 participants. PARTICIPANTS: Primary care practitioners of each country. RESULTS: In all, 1,351 PCPs gave free-text answers. We identified eighteen themes organising the content of the responses. Based on the frequency of the themes, k-means clustering identified three groups of countries. There were significant differences between clusters regarding the importance of: access to tests (p = 0.010); access to specialists (p = 0.014), screening (p < 0.001); and finances, quotas & limits (p < 0.001). CONCLUSIONS: Our study identified three distinct clusters of European countries within which PCPs had similar views on the factors that would improve the timeliness of cancer diagnosis. Further work is needed to understand what it is about the clusters that have produced these patterns, allowing healthcare systems to share best practice and to reduce disparities.
  

• 
  1.

  López-González Á A, Albaladejo Blanco M, Vidal Ribas C, Tomás-Gil P, Riutord Sbert P, Ramírez-Manent JI. Determination of the Level of Cardiovascular Risk in 172,282 Spanish Working Women. Diagnostics (Basel). 2023;13(17).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  Introduction, objectives: Although cardiovascular events have been traditionally associated mainly with men, some data reflect an increase in women, which may even exceed their male counterparts, constituting the leading cause of death in working women in Spain. The objective of this present study was to analyze the level of cardiovascular risk in Spanish working women by assessing the influence of age, type of work, and tobacco consumption. MATERIAL, METHODS: A descriptive cross-sectional study was carried out in 172,282 working women from different Spanish geographical areas and from different companies between January 2018 and June 2020. A range of variables and risk factors were assessed and various cardiovascular risk scales were used to analyze the data. RESULTS: An increase in cardiovascular risk was observed in the least qualified work groups, mainly corresponding to blue-collar workers, when using the SCORE or REGICOR risk equation. The prevalence of altered values for all the parameters analyzed (overweight and obesity, hypertension, dyslipidemia, diabetes, fatty liver, hepatic fibrosis, atherogenic indexes, and cardiovascular risk scales) was higher among blue-collar women. Age was the only factor that influenced all the cardiovascular risk scales studied, increasing risk when comparing the group of women aged 50 years and older with the others. CONCLUSIONS: Aging and belonging to the blue-collar job category meant worse results in the cardiovascular risk scales and in all the parameters analyzed. This is in line with numerous studies that argue that age and zip code are more influential than genetic code.

  @article{RN2,
  abstract = {Introduction, objectives: Although cardiovascular events have been traditionally associated mainly with men, some data reflect an increase in women, which may even exceed their male counterparts, constituting the leading cause of death in working women in Spain. The objective of this present study was to analyze the level of cardiovascular risk in Spanish working women by assessing the influence of age, type of work, and tobacco consumption. MATERIAL, METHODS: A descriptive cross-sectional study was carried out in 172,282 working women from different Spanish geographical areas and from different companies between January 2018 and June 2020. A range of variables and risk factors were assessed and various cardiovascular risk scales were used to analyze the data. RESULTS: An increase in cardiovascular risk was observed in the least qualified work groups, mainly corresponding to blue-collar workers, when using the SCORE or REGICOR risk equation. The prevalence of altered values for all the parameters analyzed (overweight and obesity, hypertension, dyslipidemia, diabetes, fatty liver, hepatic fibrosis, atherogenic indexes, and cardiovascular risk scales) was higher among blue-collar women. Age was the only factor that influenced all the cardiovascular risk scales studied, increasing risk when comparing the group of women aged 50 years and older with the others. CONCLUSIONS: Aging and belonging to the blue-collar job category meant worse results in the cardiovascular risk scales and in all the parameters analyzed. This is in line with numerous studies that argue that age and zip code are more influential than genetic code.},
  author = {López-González Á, A. and Albaladejo Blanco, M. and Vidal Ribas, C. and Tomás-Gil, P. and Riutord Sbert, P. and Ramírez-Manent, J. I.},
  journal = {Diagnostics (Basel)},
  keywords = {grapp-caib},
  number = 17,
  title = {Determination of the Level of Cardiovascular Risk in 172,282 Spanish Working Women},
  type = {Journal Article},
  volume = 13,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN2
  %A López-González Á, A.
  %A Albaladejo Blanco, M.
  %A Vidal Ribas, C.
  %A Tomás-Gil, P.
  %A Riutord Sbert, P.
  %A Ramírez-Manent, J. I.
  %D 2023
  %J Diagnostics (Basel)
  %N 17
  %R 10.3390/diagnostics13172734
  %T Determination of the Level of Cardiovascular Risk in 172,282 Spanish Working Women
  %V 13
  %X Introduction, objectives: Although cardiovascular events have been traditionally associated mainly with men, some data reflect an increase in women, which may even exceed their male counterparts, constituting the leading cause of death in working women in Spain. The objective of this present study was to analyze the level of cardiovascular risk in Spanish working women by assessing the influence of age, type of work, and tobacco consumption. MATERIAL, METHODS: A descriptive cross-sectional study was carried out in 172,282 working women from different Spanish geographical areas and from different companies between January 2018 and June 2020. A range of variables and risk factors were assessed and various cardiovascular risk scales were used to analyze the data. RESULTS: An increase in cardiovascular risk was observed in the least qualified work groups, mainly corresponding to blue-collar workers, when using the SCORE or REGICOR risk equation. The prevalence of altered values for all the parameters analyzed (overweight and obesity, hypertension, dyslipidemia, diabetes, fatty liver, hepatic fibrosis, atherogenic indexes, and cardiovascular risk scales) was higher among blue-collar women. Age was the only factor that influenced all the cardiovascular risk scales studied, increasing risk when comparing the group of women aged 50 years and older with the others. CONCLUSIONS: Aging and belonging to the blue-collar job category meant worse results in the cardiovascular risk scales and in all the parameters analyzed. This is in line with numerous studies that argue that age and zip code are more influential than genetic code.
  

• 
  1.

  Mestre Font M, Busquets-Cortés C, Ramírez-Manent JI, Tomás-Gil P, Paublini H, López-González Á A. Influence of Sociodemographic Variables and Healthy Habits on the Values of Insulin Resistance Indicators in 386,924 Spanish Workers. Nutrients. 2023;15(24).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Insulin resistance (IR) is an alteration of the action of insulin in cells, which do not respond adequately to this action, leading to an increase in blood glucose levels. IR produces a very diverse clinical picture and increases the cardiometabolic risk of the population that suffers from it. Among the factors that influence IR are genetics, unhealthy lifestyle habits, overweight, and obesity. The objective of this work was to determine how different sociodemographic variables and healthy habits influence the values of different scales that assess the risk of presenting IR in a group of Spanish workers. METHODS: An observational, cross-sectional, descriptive study was carried out in 386,924 workers from different Spanish regions. Different sociodemographic variables and lifestyle habits were studied (age, social class, educational level, smoking, Mediterranean diet, physical exercise) along with their association with four scales to evaluate the risk of insulin resistance (TyG index, TyG-BMI, METS-IR, TG/HDL-c). To analyse the quantitative variables, Student's t test was used, while the Chi-squared test was used for the qualitative variables. A multinomial logistic regression analysis was performed, calculating the odds ratio with its 95% confidence intervals. The accepted level of statistical significance was set at p < 0.05. RESULTS: In the multivariate analysis, all variables, except educational level, increased the risk of presenting high values on the IR risk scales, especially a sedentary lifestyle and low adherence to the Mediterranean diet. CONCLUSIONS: Our results demonstrate an association between the practice of regular physical exercise and a reduction in the risk of IR; a strong role of the Mediterranean diet as a protective factor for IR; an association between aging and increased IR, which has also been suggested in other studies; and, finally, a relationship between a low socioeconomic level and an increase in IR.

  @article{RN25,
  abstract = {BACKGROUND: Insulin resistance (IR) is an alteration of the action of insulin in cells, which do not respond adequately to this action, leading to an increase in blood glucose levels. IR produces a very diverse clinical picture and increases the cardiometabolic risk of the population that suffers from it. Among the factors that influence IR are genetics, unhealthy lifestyle habits, overweight, and obesity. The objective of this work was to determine how different sociodemographic variables and healthy habits influence the values of different scales that assess the risk of presenting IR in a group of Spanish workers. METHODS: An observational, cross-sectional, descriptive study was carried out in 386,924 workers from different Spanish regions. Different sociodemographic variables and lifestyle habits were studied (age, social class, educational level, smoking, Mediterranean diet, physical exercise) along with their association with four scales to evaluate the risk of insulin resistance (TyG index, TyG-BMI, METS-IR, TG/HDL-c). To analyse the quantitative variables, Student's t test was used, while the Chi-squared test was used for the qualitative variables. A multinomial logistic regression analysis was performed, calculating the odds ratio with its 95% confidence intervals. The accepted level of statistical significance was set at p < 0.05. RESULTS: In the multivariate analysis, all variables, except educational level, increased the risk of presenting high values on the IR risk scales, especially a sedentary lifestyle and low adherence to the Mediterranean diet. CONCLUSIONS: Our results demonstrate an association between the practice of regular physical exercise and a reduction in the risk of IR; a strong role of the Mediterranean diet as a protective factor for IR; an association between aging and increased IR, which has also been suggested in other studies; and, finally, a relationship between a low socioeconomic level and an increase in IR.},
  author = {Mestre Font, M. and Busquets-Cortés, C. and Ramírez-Manent, J. I. and Tomás-Gil, P. and Paublini, H. and López-González Á, A.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  number = 24,
  title = {Influence of Sociodemographic Variables and Healthy Habits on the Values of Insulin Resistance Indicators in 386,924 Spanish Workers},
  type = {Journal Article},
  volume = 15,
  year = 2023
  }
  

  %0 Journal Article
  %1 RN25
  %A Mestre Font, M.
  %A Busquets-Cortés, C.
  %A Ramírez-Manent, J. I.
  %A Tomás-Gil, P.
  %A Paublini, H.
  %A López-González Á, A.
  %D 2023
  %J Nutrients
  %N 24
  %R 10.3390/nu15245122
  %T Influence of Sociodemographic Variables and Healthy Habits on the Values of Insulin Resistance Indicators in 386,924 Spanish Workers
  %V 15
  %X BACKGROUND: Insulin resistance (IR) is an alteration of the action of insulin in cells, which do not respond adequately to this action, leading to an increase in blood glucose levels. IR produces a very diverse clinical picture and increases the cardiometabolic risk of the population that suffers from it. Among the factors that influence IR are genetics, unhealthy lifestyle habits, overweight, and obesity. The objective of this work was to determine how different sociodemographic variables and healthy habits influence the values of different scales that assess the risk of presenting IR in a group of Spanish workers. METHODS: An observational, cross-sectional, descriptive study was carried out in 386,924 workers from different Spanish regions. Different sociodemographic variables and lifestyle habits were studied (age, social class, educational level, smoking, Mediterranean diet, physical exercise) along with their association with four scales to evaluate the risk of insulin resistance (TyG index, TyG-BMI, METS-IR, TG/HDL-c). To analyse the quantitative variables, Student's t test was used, while the Chi-squared test was used for the qualitative variables. A multinomial logistic regression analysis was performed, calculating the odds ratio with its 95% confidence intervals. The accepted level of statistical significance was set at p < 0.05. RESULTS: In the multivariate analysis, all variables, except educational level, increased the risk of presenting high values on the IR risk scales, especially a sedentary lifestyle and low adherence to the Mediterranean diet. CONCLUSIONS: Our results demonstrate an association between the practice of regular physical exercise and a reduction in the risk of IR; a strong role of the Mediterranean diet as a protective factor for IR; an association between aging and increased IR, which has also been suggested in other studies; and, finally, a relationship between a low socioeconomic level and an increase in IR.
  

2022

• 
  1.

  Bibiloni MDM, Gallardo-Alfaro L, Gómez SF, Wärnberg J, Osés-Recalde M, González-Gross M, Gusi N, Aznar S, Marín-Cascales E, González-Valeiro M, Serra-Majem L, Terrados N, Segu M, Lassale C, Homs C, Benavente-Marín JC, Labayen I, Zapico AG, Sánchez-Gómez J, Jiménez-Zazo F, Alcaraz PE, Sevilla-Sánchez M, Herrera-Ramos E, Pulgar S, Sistac C, Schröder H, Bouzas C, Tur JA. Combined Body Mass Index and Waist-to-Height Ratio and Its Association with Lifestyle and Health Factors among Spanish Children: The PASOS Study. Nutrients. 2022;14(2).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND AND AIMS: The World Health Organization recommended simultaneous measurement of body mass index (BMI) and waist circumference (WC) and suggested joint use to predict disease risks. The aim of this study was to assess the prevalence of BMI and waist-to-height ratio (WHtR) categories among Spanish children and adolescents, as well as their associations with several lifestyle factors. METHODS: Cross-sectional analysis of 8-16-year-old children and adolescents (n = 3772) were included in the PASOS nationwide representative study. Children/adolescents and their mothers/female caregivers answered a questionnaire on lifestyle and health factors. Child/adolescent anthropometrics were measured. Four combined BMI-WHtR disease risk categories were built. RESULTS: A third of participants showed combined BMI-WHtR categories with high disease risk (12.3% 'increased risk', 9.7% 'high risk', 14.3% 'very high risk'). Participants in the 'very high risk' group were less likely to be females (odds ratio 0.63; 95% CI: 0.52-0.76) and adolescents (0.60; 95% CI: 0.49-0.72), to practice ≥60 min/day of moderate-vigorous physical activity (MVPA) (0.73; 95% CI: 0.57-0.93), and to watch <120 min/day of total screen time on weekdays (0.61; 95% CI: 0.49-0.76). Mothers of participants in the 'very high risk' group were less likely to have a high educational level, be in the overweight or normal range, have never smoked or were former smokers, and watch <120 min/day of total screen time on weekends. Participants in the 'increased' and 'high risk' categories had mothers with normal weight and ≥60 min/day of MVPA. Participants in the 'high risk' group did not achieve ≥60 min/day of MVPA and showed lower adherence to the Mediterranean diet. CONCLUSIONS: Adherence to a healthy lifestyle in children and adolescents, but also in their mothers/female caregivers during offspring's childhood and adolescence, is associated with low BMI-WHtR disease risk.

  @article{RN78,
  abstract = {BACKGROUND AND AIMS: The World Health Organization recommended simultaneous measurement of body mass index (BMI) and waist circumference (WC) and suggested joint use to predict disease risks. The aim of this study was to assess the prevalence of BMI and waist-to-height ratio (WHtR) categories among Spanish children and adolescents, as well as their associations with several lifestyle factors. METHODS: Cross-sectional analysis of 8-16-year-old children and adolescents (n = 3772) were included in the PASOS nationwide representative study. Children/adolescents and their mothers/female caregivers answered a questionnaire on lifestyle and health factors. Child/adolescent anthropometrics were measured. Four combined BMI-WHtR disease risk categories were built. RESULTS: A third of participants showed combined BMI-WHtR categories with high disease risk (12.3% 'increased risk', 9.7% 'high risk', 14.3% 'very high risk'). Participants in the 'very high risk' group were less likely to be females (odds ratio 0.63; 95% CI: 0.52-0.76) and adolescents (0.60; 95% CI: 0.49-0.72), to practice ≥60 min/day of moderate-vigorous physical activity (MVPA) (0.73; 95% CI: 0.57-0.93), and to watch <120 min/day of total screen time on weekdays (0.61; 95% CI: 0.49-0.76). Mothers of participants in the 'very high risk' group were less likely to have a high educational level, be in the overweight or normal range, have never smoked or were former smokers, and watch <120 min/day of total screen time on weekends. Participants in the 'increased' and 'high risk' categories had mothers with normal weight and ≥60 min/day of MVPA. Participants in the 'high risk' group did not achieve ≥60 min/day of MVPA and showed lower adherence to the Mediterranean diet. CONCLUSIONS: Adherence to a healthy lifestyle in children and adolescents, but also in their mothers/female caregivers during offspring's childhood and adolescence, is associated with low BMI-WHtR disease risk.},
  author = {Bibiloni, M. D. M. and Gallardo-Alfaro, L. and Gómez, S. F. and Wärnberg, J. and Osés-Recalde, M. and González-Gross, M. and Gusi, N. and Aznar, S. and Marín-Cascales, E. and González-Valeiro, M. and Serra-Majem, L. and Terrados, N. and Segu, M. and Lassale, C. and Homs, C. and Benavente-Marín, J. C. and Labayen, I. and Zapico, A. G. and Sánchez-Gómez, J. and Jiménez-Zazo, F. and Alcaraz, P. E. and Sevilla-Sánchez, M. and Herrera-Ramos, E. and Pulgar, S. and Sistac, C. and Schröder, H. and Bouzas, C. and Tur, J. A.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  number = 2,
  title = {Combined Body Mass Index and Waist-to-Height Ratio and Its Association with Lifestyle and Health Factors among Spanish Children: The PASOS Study},
  type = {Journal Article},
  volume = 14,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN78
  %A Bibiloni, M. D. M.
  %A Gallardo-Alfaro, L.
  %A Gómez, S. F.
  %A Wärnberg, J.
  %A Osés-Recalde, M.
  %A González-Gross, M.
  %A Gusi, N.
  %A Aznar, S.
  %A Marín-Cascales, E.
  %A González-Valeiro, M.
  %A Serra-Majem, L.
  %A Terrados, N.
  %A Segu, M.
  %A Lassale, C.
  %A Homs, C.
  %A Benavente-Marín, J. C.
  %A Labayen, I.
  %A Zapico, A. G.
  %A Sánchez-Gómez, J.
  %A Jiménez-Zazo, F.
  %A Alcaraz, P. E.
  %A Sevilla-Sánchez, M.
  %A Herrera-Ramos, E.
  %A Pulgar, S.
  %A Sistac, C.
  %A Schröder, H.
  %A Bouzas, C.
  %A Tur, J. A.
  %D 2022
  %J Nutrients
  %N 2
  %R 10.3390/nu14020234
  %T Combined Body Mass Index and Waist-to-Height Ratio and Its Association with Lifestyle and Health Factors among Spanish Children: The PASOS Study
  %V 14
  %X BACKGROUND AND AIMS: The World Health Organization recommended simultaneous measurement of body mass index (BMI) and waist circumference (WC) and suggested joint use to predict disease risks. The aim of this study was to assess the prevalence of BMI and waist-to-height ratio (WHtR) categories among Spanish children and adolescents, as well as their associations with several lifestyle factors. METHODS: Cross-sectional analysis of 8-16-year-old children and adolescents (n = 3772) were included in the PASOS nationwide representative study. Children/adolescents and their mothers/female caregivers answered a questionnaire on lifestyle and health factors. Child/adolescent anthropometrics were measured. Four combined BMI-WHtR disease risk categories were built. RESULTS: A third of participants showed combined BMI-WHtR categories with high disease risk (12.3% 'increased risk', 9.7% 'high risk', 14.3% 'very high risk'). Participants in the 'very high risk' group were less likely to be females (odds ratio 0.63; 95% CI: 0.52-0.76) and adolescents (0.60; 95% CI: 0.49-0.72), to practice ≥60 min/day of moderate-vigorous physical activity (MVPA) (0.73; 95% CI: 0.57-0.93), and to watch <120 min/day of total screen time on weekdays (0.61; 95% CI: 0.49-0.76). Mothers of participants in the 'very high risk' group were less likely to have a high educational level, be in the overweight or normal range, have never smoked or were former smokers, and watch <120 min/day of total screen time on weekends. Participants in the 'increased' and 'high risk' categories had mothers with normal weight and ≥60 min/day of MVPA. Participants in the 'high risk' group did not achieve ≥60 min/day of MVPA and showed lower adherence to the Mediterranean diet. CONCLUSIONS: Adherence to a healthy lifestyle in children and adolescents, but also in their mothers/female caregivers during offspring's childhood and adolescence, is associated with low BMI-WHtR disease risk.
  

• 
  1.

  Zamanillo-Campos R, Chaplin A, Romaguera D, Abete I, Salas-Salvadó J, Martín V, Estruch R, Vidal J, Ruiz-Canela M, Babio N, Fiol F, de Paz JA, Casas R, Olbeyra R, Martínez-González MA, García-Gavilán JF, Goday A, Fernandez-Lazaro CI, Martínez JA, Hu FB, Konieczna J. Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators. Clinical nutrition (Edinburgh, Scotland) [Internet]. England; 2022 Oct.;41(10):2264-7. https://pubmed.ncbi.nlm.nih.gov/36084360

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUND & AIMS: The quality of dietary carbohydrates rather than total carbohydrate intake may determine the accumulation of visceral fat; however, to date, few studies have examined the impact of diet on adiposity using specific imaging techniques. Thus, the aim of this prospective study was to investigate the association between concurrent changes in carbohydrate quality index (CQI) and objectively-quantified adiposity distribution over a year. METHODS: We analyzed a cohort of 1476 participants aged 55-75 years with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus randomized controlled trial. Dietary intake information was obtained at baseline, 6- and 12-months from a validated 143-item semi-quantitative food-frequency questionnaire, and CQI (range: 4 to 20) was calculated based on four dietary criteria: total dietary fibre, glycemic index, wholegrain/total grain carbohydrate ratio, and solid/total carbohydrate ratio. Overall and regional adiposity (total body fat, visceral fat and android-to-gynoid fat ratio) was quantified using dual-energy X-ray absorptiometry at all three time points. Multiple adjusted linear mixed-effects models were used to assess associations between concurrent changes in repeatedly measured CQI and adiposity over time. RESULTS: After controlling for potential confounding factors, a 3-point increment in CQI over 12-month follow-up was associated with a decrease in visceral fat (β -0.067 z-score, 95% CI -0.088; -0.046, p < 0.001), android-to-gynoid fat ratio (-0.038, -0.059; -0.017, p < 0.001), and total fat (-0.064, -0.080; -0.047, p < 0.001). Fibre intake and the ratio of wholegrain/total grain showed the strongest inverse associations with all adiposity indicators. CONCLUSIONS: In this prospective cohort of older adults with overweight/obesity and MetS, we found that improvements in dietary carbohydrate quality over a year were associated with concurrent favorable changes in visceral and overall fat deposition. These associations were mostly driven by dietary fibre and the wholegrain/total grain ratio. TRIAL REGISTRATION: The trial was registered at the International Standard Randomized. CONTROLLED TRIAL: (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

  @article{zamanillocampos2022longitudinal,
  abstract = {BACKGROUND & AIMS: The quality of dietary carbohydrates rather than total carbohydrate intake may determine the accumulation of visceral fat; however, to date, few studies have examined the impact of diet on adiposity using specific imaging techniques. Thus, the aim of this prospective study was to investigate the association between concurrent changes in carbohydrate quality index (CQI) and objectively-quantified adiposity distribution over a year. METHODS: We analyzed a cohort of 1476 participants aged 55-75 years with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus randomized controlled trial. Dietary intake information was obtained at baseline, 6- and 12-months from a validated 143-item semi-quantitative food-frequency questionnaire, and CQI (range: 4 to 20) was calculated based on four dietary criteria: total dietary fibre, glycemic index, wholegrain/total grain carbohydrate ratio, and solid/total carbohydrate ratio. Overall and regional adiposity (total body fat, visceral fat and android-to-gynoid fat ratio) was quantified using dual-energy X-ray absorptiometry at all three time points. Multiple adjusted linear mixed-effects models were used to assess associations between concurrent changes in repeatedly measured CQI and adiposity over time. RESULTS: After controlling for potential confounding factors, a 3-point increment in CQI over 12-month follow-up was associated with a decrease in visceral fat (β -0.067 z-score, 95% CI -0.088; -0.046, p < 0.001), android-to-gynoid fat ratio (-0.038, -0.059; -0.017, p < 0.001), and total fat (-0.064, -0.080; -0.047, p < 0.001). Fibre intake and the ratio of wholegrain/total grain showed the strongest inverse associations with all adiposity indicators. CONCLUSIONS: In this prospective cohort of older adults with overweight/obesity and MetS, we found that improvements in dietary carbohydrate quality over a year were associated with concurrent favorable changes in visceral and overall fat deposition. These associations were mostly driven by dietary fibre and the wholegrain/total grain ratio. TRIAL REGISTRATION: The trial was registered at the International Standard Randomized. CONTROLLED TRIAL: (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.},
  address = {England},
  author = {Zamanillo-Campos, Rocío and Chaplin, Alice and Romaguera, Dora and Abete, Itziar and Salas-Salvadó, Jordi and Martín, Vicente and Estruch, Ramón and Vidal, Josep and Ruiz-Canela, Miguel and Babio, Nancy and Fiol, Francisca and de Paz, José Antonio and Casas, Rosa and Olbeyra, Romina and Martínez-González, Miguel A and García-Gavilán, Jesús F and Goday, Albert and Fernandez-Lazaro, Cesar I and Martínez, J Alfredo and Hu, Frank B and Konieczna, Jadwiga},
  journal = {Clinical nutrition (Edinburgh, Scotland)},
  keywords = {evisap},
  month = {oct},
  number = 10,
  pages = {2264--2274},
  title = {Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators},
  volume = 41,
  year = 2022
  }
  

  %0 Journal Article
  %1 zamanillocampos2022longitudinal
  %A Zamanillo-Campos, Rocío
  %A Chaplin, Alice
  %A Romaguera, Dora
  %A Abete, Itziar
  %A Salas-Salvadó, Jordi
  %A Martín, Vicente
  %A Estruch, Ramón
  %A Vidal, Josep
  %A Ruiz-Canela, Miguel
  %A Babio, Nancy
  %A Fiol, Francisca
  %A de Paz, José Antonio
  %A Casas, Rosa
  %A Olbeyra, Romina
  %A Martínez-González, Miguel A
  %A García-Gavilán, Jesús F
  %A Goday, Albert
  %A Fernandez-Lazaro, Cesar I
  %A Martínez, J Alfredo
  %A Hu, Frank B
  %A Konieczna, Jadwiga
  %C England
  %D 2022
  %J Clinical nutrition (Edinburgh, Scotland)
  %N 10
  %P 2264--2274
  %R 10.1016/j.clnu.2022.08.008
  %T Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators
  %U https://pubmed.ncbi.nlm.nih.gov/36084360
  %V 41
  %X BACKGROUND & AIMS: The quality of dietary carbohydrates rather than total carbohydrate intake may determine the accumulation of visceral fat; however, to date, few studies have examined the impact of diet on adiposity using specific imaging techniques. Thus, the aim of this prospective study was to investigate the association between concurrent changes in carbohydrate quality index (CQI) and objectively-quantified adiposity distribution over a year. METHODS: We analyzed a cohort of 1476 participants aged 55-75 years with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus randomized controlled trial. Dietary intake information was obtained at baseline, 6- and 12-months from a validated 143-item semi-quantitative food-frequency questionnaire, and CQI (range: 4 to 20) was calculated based on four dietary criteria: total dietary fibre, glycemic index, wholegrain/total grain carbohydrate ratio, and solid/total carbohydrate ratio. Overall and regional adiposity (total body fat, visceral fat and android-to-gynoid fat ratio) was quantified using dual-energy X-ray absorptiometry at all three time points. Multiple adjusted linear mixed-effects models were used to assess associations between concurrent changes in repeatedly measured CQI and adiposity over time. RESULTS: After controlling for potential confounding factors, a 3-point increment in CQI over 12-month follow-up was associated with a decrease in visceral fat (β -0.067 z-score, 95% CI -0.088; -0.046, p < 0.001), android-to-gynoid fat ratio (-0.038, -0.059; -0.017, p < 0.001), and total fat (-0.064, -0.080; -0.047, p < 0.001). Fibre intake and the ratio of wholegrain/total grain showed the strongest inverse associations with all adiposity indicators. CONCLUSIONS: In this prospective cohort of older adults with overweight/obesity and MetS, we found that improvements in dietary carbohydrate quality over a year were associated with concurrent favorable changes in visceral and overall fat deposition. These associations were mostly driven by dietary fibre and the wholegrain/total grain ratio. TRIAL REGISTRATION: The trial was registered at the International Standard Randomized. CONTROLLED TRIAL: (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.
  

• 
  1.

  Bibiloni MDM, Gallardo-Alfaro L, Gómez SF, Wärnberg J, Osés-Recalde M, González-Gross M, Gusi N, Aznar S, Marín-Cascales E, González-Valeiro MA, Serra-Majem L, Terrados N, Segu M, Lassale C, Homs C, Benavente-Marín JC, Labayen I, Zapico AG, Sánchez-Gómez J, Jiménez-Zazo F, Alcaraz PE, Sevilla-Sánchez M, Herrera-Ramos E, Pulgar S, Sistac C, Schröder H, Bouzas C, Tur JA. Determinants of Adherence to the Mediterranean Diet in Spanish Children and Adolescents: The PASOS Study. Nutrients. 2022;14(4).

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  A progressive shift away from traditional healthy dietary patterns, such as the Mediterranean diet (MedDiet), has been observed in recent decades. The aim of this study was to assess determinants of optimal adherence to the MedDiet in Spanish children and adolescents. A cross-sectional analysis was included in the PASOS nationwide representative study in Spain. Participants were 3607 children and adolescents; 8-16 years old. Primary and secondary outcome measures of weight and height were measured. Adherence to the MedDiet, physical activity, and sedentary behavior in children and adolescents, as well as parental physical activity and dietary habits, were assessed. Optimal adherence to the MedDiet was observed in 45.5% of primary school students and 34.8% of secondary school students (OR: 0.65; 95%CI: 0.56-0.75). Optimal adherence to the MedDiet was higher in children/adolescents meeting daily recommended moderate and vigorous physical activity (OR: 2.39, 95%CI: 1.97-2.89) and in those meeting daily recommended screen time on weekdays (OR: 2.05, 95%CI: 1.77-2.38) and weekends (OR: 1.76, 95%CI: 1.48-2.10). Participants with optimal adherence to the MedDiet were more likely to have mothers with a high-level education and high-tercile of SDQS, mothers who never smoked or were former smokers, and mothers who met the recommended physical activity and screen time. It can be concluded that a low prevalence of optimal adherence to the MedDiet was found among current Spanish children and adolescents. Optimal adherence to the MedDiet was associated with reaching the recommendations on physical activity and screen time, with the highest maternal educational level, and healthier maternal lifestyles.

  @article{RN77,
  abstract = {A progressive shift away from traditional healthy dietary patterns, such as the Mediterranean diet (MedDiet), has been observed in recent decades. The aim of this study was to assess determinants of optimal adherence to the MedDiet in Spanish children and adolescents. A cross-sectional analysis was included in the PASOS nationwide representative study in Spain. Participants were 3607 children and adolescents; 8-16 years old. Primary and secondary outcome measures of weight and height were measured. Adherence to the MedDiet, physical activity, and sedentary behavior in children and adolescents, as well as parental physical activity and dietary habits, were assessed. Optimal adherence to the MedDiet was observed in 45.5% of primary school students and 34.8% of secondary school students (OR: 0.65; 95%CI: 0.56-0.75). Optimal adherence to the MedDiet was higher in children/adolescents meeting daily recommended moderate and vigorous physical activity (OR: 2.39, 95%CI: 1.97-2.89) and in those meeting daily recommended screen time on weekdays (OR: 2.05, 95%CI: 1.77-2.38) and weekends (OR: 1.76, 95%CI: 1.48-2.10). Participants with optimal adherence to the MedDiet were more likely to have mothers with a high-level education and high-tercile of SDQS, mothers who never smoked or were former smokers, and mothers who met the recommended physical activity and screen time. It can be concluded that a low prevalence of optimal adherence to the MedDiet was found among current Spanish children and adolescents. Optimal adherence to the MedDiet was associated with reaching the recommendations on physical activity and screen time, with the highest maternal educational level, and healthier maternal lifestyles.},
  author = {Bibiloni, M. D. M. and Gallardo-Alfaro, L. and Gómez, S. F. and Wärnberg, J. and Osés-Recalde, M. and González-Gross, M. and Gusi, N. and Aznar, S. and Marín-Cascales, E. and González-Valeiro, M. A. and Serra-Majem, L. and Terrados, N. and Segu, M. and Lassale, C. and Homs, C. and Benavente-Marín, J. C. and Labayen, I. and Zapico, A. G. and Sánchez-Gómez, J. and Jiménez-Zazo, F. and Alcaraz, P. E. and Sevilla-Sánchez, M. and Herrera-Ramos, E. and Pulgar, S. and Sistac, C. and Schröder, H. and Bouzas, C. and Tur, J. A.},
  journal = {Nutrients},
  keywords = {grapp-caib},
  number = 4,
  title = {Determinants of Adherence to the Mediterranean Diet in Spanish Children and Adolescents: The PASOS Study},
  type = {Journal Article},
  volume = 14,
  year = 2022
  }
  

  %0 Journal Article
  %1 RN77
  %A Bibiloni, M. D. M.
  %A Gallardo-Alfaro, L.
  %A Gómez, S. F.
  %A Wärnberg, J.
  %A Osés-Recalde, M.
  %A González-Gross, M.
  %A Gusi, N.
  %A Aznar, S.
  %A Marín-Cascales, E.
  %A González-Valeiro, M. A.
  %A Serra-Majem, L.
  %A Terrados, N.
  %A Segu, M.
  %A Lassale, C.
  %A Homs, C.
  %A Benavente-Marín, J. C.
  %A Labayen, I.
  %A Zapico, A. G.
  %A Sánchez-Gómez, J.
  %A Jiménez-Zazo, F.
  %A Alcaraz, P. E.
  %A Sevilla-Sánchez, M.
  %A Herrera-Ramos, E.
  %A Pulgar, S.
  %A Sistac, C.
  %A Schröder, H.
  %A Bouzas, C.
  %A Tur, J. A.
  %D 2022
  %J Nutrients
  %N 4
  %R 10.3390/nu14040738
  %T Determinants of Adherence to the Mediterranean Diet in Spanish Children and Adolescents: The PASOS Study
  %V 14
  %X A progressive shift away from traditional healthy dietary patterns, such as the Mediterranean diet (MedDiet), has been observed in recent decades. The aim of this study was to assess determinants of optimal adherence to the MedDiet in Spanish children and adolescents. A cross-sectional analysis was included in the PASOS nationwide representative study in Spain. Participants were 3607 children and adolescents; 8-16 years old. Primary and secondary outcome measures of weight and height were measured. Adherence to the MedDiet, physical activity, and sedentary behavior in children and adolescents, as well as parental physical activity and dietary habits, were assessed. Optimal adherence to the MedDiet was observed in 45.5% of primary school students and 34.8% of secondary school students (OR: 0.65; 95%CI: 0.56-0.75). Optimal adherence to the MedDiet was higher in children/adolescents meeting daily recommended moderate and vigorous physical activity (OR: 2.39, 95%CI: 1.97-2.89) and in those meeting daily recommended screen time on weekdays (OR: 2.05, 95%CI: 1.77-2.38) and weekends (OR: 1.76, 95%CI: 1.48-2.10). Participants with optimal adherence to the MedDiet were more likely to have mothers with a high-level education and high-tercile of SDQS, mothers who never smoked or were former smokers, and mothers who met the recommended physical activity and screen time. It can be concluded that a low prevalence of optimal adherence to the MedDiet was found among current Spanish children and adolescents. Optimal adherence to the MedDiet was associated with reaching the recommendations on physical activity and screen time, with the highest maternal educational level, and healthier maternal lifestyles.
  

• 
  1.

  Serrano-Ripoll MJ, Llobera J, Valderas JM, de Labry Lima AO, Fiol deRoque MA, Ripoll J, Ricci-Cabello I. Cross-Cultural Adaptation, Validation, and Piloting of the Patient Reported Experiences and Outcomes of Safety in Primary Care Questionnaire for Its Use in Spain. Journal of patient safety [Internet]. United States; 2022 Mar.;18(2):102-10. https://pubmed.ncbi.nlm.nih.gov/35188925

  AbstractURLBibTeXEndNoteDOIBibSonomy

  OBJECTIVE: This study aimed to cross-culturally adapt, validate, and pilot the Patient Reported Experiences and Outcomes of Safety in Primary Care questionnaire for its use in Spain. METHODS: After setting up an expert panel to determine its content validity, the questionnaire was translated and back-translated, and subjected to cognitive testing. The questionnaire was piloted in a cross-sectional study in 10 primary health care centers in Spain. Fifty patients per center completed the questionnaire while waiting for an appointment. We estimated (i) the acceptability of the questionnaire (response rate), (ii) scores distribution (floor and ceiling effects), (iii) internal consistency (Cronbach α), and (iv) construct validity (exploratory factor analyses and correlation between scales). To examine patients' evaluations of patient safety, we followed a mixed-methods approach: (i) statistical analyses at the scale and item levels based on responses to standardized items and (ii) qualitative content analysis based on responses to open-ended questions. RESULTS: Complete data were collected from 493 patients (participation rate, 77%). A ceiling effect was observed for 3 scales ("safety problems," "harm severity," "harm needs"). The internal consistency was adequate (α > 0.7) for the majority of scales. Exploratory factor analysis and correlation between scales suggested an appropriate construct validity. Two hundred twenty-six (45.8%) respondents experienced at least 1 safety problem, and 109 (23.2%) reported harm in the previous 12 months. CONCLUSIONS: The multidimensional primary health care patient safety instrument Patient Reported Experiences and Outcomes of Safety in Primary Care is now available for its use in Spain. Initial testing demonstrates its potential for use in primary care. Future developments will further address its use in actual clinical practice.

  @article{serranoripoll2022crosscultural,
  abstract = {OBJECTIVE: This study aimed to cross-culturally adapt, validate, and pilot the Patient Reported Experiences and Outcomes of Safety in Primary Care questionnaire for its use in Spain. METHODS: After setting up an expert panel to determine its content validity, the questionnaire was translated and back-translated, and subjected to cognitive testing. The questionnaire was piloted in a cross-sectional study in 10 primary health care centers in Spain. Fifty patients per center completed the questionnaire while waiting for an appointment. We estimated (i) the acceptability of the questionnaire (response rate), (ii) scores distribution (floor and ceiling effects), (iii) internal consistency (Cronbach α), and (iv) construct validity (exploratory factor analyses and correlation between scales). To examine patients' evaluations of patient safety, we followed a mixed-methods approach: (i) statistical analyses at the scale and item levels based on responses to standardized items and (ii) qualitative content analysis based on responses to open-ended questions. RESULTS: Complete data were collected from 493 patients (participation rate, 77%). A ceiling effect was observed for 3 scales ("safety problems," "harm severity," "harm needs"). The internal consistency was adequate (α > 0.7) for the majority of scales. Exploratory factor analysis and correlation between scales suggested an appropriate construct validity. Two hundred twenty-six (45.8%) respondents experienced at least 1 safety problem, and 109 (23.2%) reported harm in the previous 12 months. CONCLUSIONS: The multidimensional primary health care patient safety instrument Patient Reported Experiences and Outcomes of Safety in Primary Care is now available for its use in Spain. Initial testing demonstrates its potential for use in primary care. Future developments will further address its use in actual clinical practice.},
  address = {United States},
  author = {Serrano-Ripoll, María J and Llobera, Joan and Valderas, José M and de Labry Lima, Antonio Olry and Fiol deRoque, María A and Ripoll, Joana and Ricci-Cabello, Ignacio},
  journal = {Journal of patient safety},
  keywords = {evisap},
  month = {mar},
  number = 2,
  pages = {102--110},
  title = {Cross-Cultural Adaptation, Validation, and Piloting of the Patient Reported Experiences and Outcomes of Safety in Primary Care Questionnaire for Its Use in Spain},
  volume = 18,
  year = 2022
  }
  

  %0 Journal Article
  %1 serranoripoll2022crosscultural
  %A Serrano-Ripoll, María J
  %A Llobera, Joan
  %A Valderas, José M
  %A de Labry Lima, Antonio Olry
  %A Fiol deRoque, María A
  %A Ripoll, Joana
  %A Ricci-Cabello, Ignacio
  %C United States
  %D 2022
  %J Journal of patient safety
  %N 2
  %P 102--110
  %R 10.1097/PTS.0000000000000819
  %T Cross-Cultural Adaptation, Validation, and Piloting of the Patient Reported Experiences and Outcomes of Safety in Primary Care Questionnaire for Its Use in Spain
  %U https://pubmed.ncbi.nlm.nih.gov/35188925
  %V 18
  %X OBJECTIVE: This study aimed to cross-culturally adapt, validate, and pilot the Patient Reported Experiences and Outcomes of Safety in Primary Care questionnaire for its use in Spain. METHODS: After setting up an expert panel to determine its content validity, the questionnaire was translated and back-translated, and subjected to cognitive testing. The questionnaire was piloted in a cross-sectional study in 10 primary health care centers in Spain. Fifty patients per center completed the questionnaire while waiting for an appointment. We estimated (i) the acceptability of the questionnaire (response rate), (ii) scores distribution (floor and ceiling effects), (iii) internal consistency (Cronbach α), and (iv) construct validity (exploratory factor analyses and correlation between scales). To examine patients' evaluations of patient safety, we followed a mixed-methods approach: (i) statistical analyses at the scale and item levels based on responses to standardized items and (ii) qualitative content analysis based on responses to open-ended questions. RESULTS: Complete data were collected from 493 patients (participation rate, 77%). A ceiling effect was observed for 3 scales ("safety problems," "harm severity," "harm needs"). The internal consistency was adequate (α > 0.7) for the majority of scales. Exploratory factor analysis and correlation between scales suggested an appropriate construct validity. Two hundred twenty-six (45.8%) respondents experienced at least 1 safety problem, and 109 (23.2%) reported harm in the previous 12 months. CONCLUSIONS: The multidimensional primary health care patient safety instrument Patient Reported Experiences and Outcomes of Safety in Primary Care is now available for its use in Spain. Initial testing demonstrates its potential for use in primary care. Future developments will further address its use in actual clinical practice.
  

• 
  1.

  Mounce LTA, Salema N-E, Gangannagaripalli J, Ricci-Cabello I, Avery AJ, Kadam UT, Valderas JM. Development of 2 Short Patient-Report Questionnaires of Patient Safety in Primary Care. Journal of patient safety [Internet]. United States; 2022 Apr.;18(3):161-70. https://pubmed.ncbi.nlm.nih.gov/35344976

  AbstractURLBibTeXEndNoteDOIBibSonomy

  OBJECTIVES: The Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) is a valid and reliable instrument (61 items across 5 domains) of patients' perceptions of safety. Stakeholder feedback has supported shorter versions for improving choice and facilitating uptake of routine patient-centered evaluation. We sought to develop 2 shorter versions of PREOS-PC: one including the shortest possible scales that met established measurement performance standards and a screening version including a single item per domain. METHODS: A total of 1244 patients from 45 general practices across England completed PREOS-PC questionnaires. All scale items in PREOS-PC underwent Item Response Theory analysis, applying standard criteria for the item reduction. Cognitive debriefing from 10 patient interviews allowed for the assessment of the instruments' readability. The instruments' psychometrics properties were reassessed in a validation sample of 1557 patients in 21 English general practices. RESULTS: "PREOS-PC Compact" includes 25 items and 2 open-ended questions across the 5 domains, 44% of the length of the original instrument. "PREOS-PC Screen" consists of 6 items: the best-performing single items for 2 domains, 1 item modified from original items for each of the remaining 3 domains, and 1 open-ended question. The evaluation of the instruments confirmed they were acceptable to patients and met standards for readability; construct, convergent, and divergent validity; and reliability. CONCLUSIONS: PREOS-PC Compact meets high-performance standards while reducing patient burden for routine monitoring of patient safety in primary care. PREOS-PC Screen is a concise tool apt for incorporation into audits and to target more in-depth review as needed.

  @article{mounce2022development,
  abstract = {OBJECTIVES: The Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) is a valid and reliable instrument (61 items across 5 domains) of patients' perceptions of safety. Stakeholder feedback has supported shorter versions for improving choice and facilitating uptake of routine patient-centered evaluation. We sought to develop 2 shorter versions of PREOS-PC: one including the shortest possible scales that met established measurement performance standards and a screening version including a single item per domain. METHODS: A total of 1244 patients from 45 general practices across England completed PREOS-PC questionnaires. All scale items in PREOS-PC underwent Item Response Theory analysis, applying standard criteria for the item reduction. Cognitive debriefing from 10 patient interviews allowed for the assessment of the instruments' readability. The instruments' psychometrics properties were reassessed in a validation sample of 1557 patients in 21 English general practices. RESULTS: "PREOS-PC Compact" includes 25 items and 2 open-ended questions across the 5 domains, 44% of the length of the original instrument. "PREOS-PC Screen" consists of 6 items: the best-performing single items for 2 domains, 1 item modified from original items for each of the remaining 3 domains, and 1 open-ended question. The evaluation of the instruments confirmed they were acceptable to patients and met standards for readability; construct, convergent, and divergent validity; and reliability. CONCLUSIONS: PREOS-PC Compact meets high-performance standards while reducing patient burden for routine monitoring of patient safety in primary care. PREOS-PC Screen is a concise tool apt for incorporation into audits and to target more in-depth review as needed.},
  address = {United States},
  author = {Mounce, Luke T A and Salema, Nde-Eshimuni and Gangannagaripalli, Jaheeda and Ricci-Cabello, Ignacio and Avery, Anthony J and Kadam, Umesh T and Valderas, José M},
  journal = {Journal of patient safety},
  keywords = {evisap},
  month = {apr},
  number = 3,
  pages = {161--170},
  title = {Development of 2 Short Patient-Report Questionnaires of Patient Safety in Primary Care},
  volume = 18,
  year = 2022
  }
  

  %0 Journal Article
  %1 mounce2022development
  %A Mounce, Luke T A
  %A Salema, Nde-Eshimuni
  %A Gangannagaripalli, Jaheeda
  %A Ricci-Cabello, Ignacio
  %A Avery, Anthony J
  %A Kadam, Umesh T
  %A Valderas, José M
  %C United States
  %D 2022
  %J Journal of patient safety
  %N 3
  %P 161--170
  %R 10.1097/PTS.0000000000000880
  %T Development of 2 Short Patient-Report Questionnaires of Patient Safety in Primary Care
  %U https://pubmed.ncbi.nlm.nih.gov/35344976
  %V 18
  %X OBJECTIVES: The Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) is a valid and reliable instrument (61 items across 5 domains) of patients' perceptions of safety. Stakeholder feedback has supported shorter versions for improving choice and facilitating uptake of routine patient-centered evaluation. We sought to develop 2 shorter versions of PREOS-PC: one including the shortest possible scales that met established measurement performance standards and a screening version including a single item per domain. METHODS: A total of 1244 patients from 45 general practices across England completed PREOS-PC questionnaires. All scale items in PREOS-PC underwent Item Response Theory analysis, applying standard criteria for the item reduction. Cognitive debriefing from 10 patient interviews allowed for the assessment of the instruments' readability. The instruments' psychometrics properties were reassessed in a validation sample of 1557 patients in 21 English general practices. RESULTS: "PREOS-PC Compact" includes 25 items and 2 open-ended questions across the 5 domains, 44% of the length of the original instrument. "PREOS-PC Screen" consists of 6 items: the best-performing single items for 2 domains, 1 item modified from original items for each of the remaining 3 domains, and 1 open-ended question. The evaluation of the instruments confirmed they were acceptable to patients and met standards for readability; construct, convergent, and divergent validity; and reliability. CONCLUSIONS: PREOS-PC Compact meets high-performance standards while reducing patient burden for routine monitoring of patient safety in primary care. PREOS-PC Screen is a concise tool apt for incorporation into audits and to target more in-depth review as needed.
  

• 
  1.

  Galmes-Panades AM, Angullo E, Mira-Martínez S, Bennasar-Veny M, Zamanillo-Campos R, Gómez-Juanes R, Konieczna J, Jiménez R, Serrano-Ripoll MJ, Fiol deRoque MA, Miralles J, Yañez AM, Romaguera D, Vidal-Thomas MC, Llobera-Canaves J, García-Toro M, Vicens C, Gervilla-García E, Oña JI, Malih N, Leiva A, Bulilete O, Montaño JJ, Gili M, Roca M, Ricci-Cabello I. Development and Evaluation of a Digital Health Intervention to Prevent Type 2 Diabetes in Primary Care: The PREDIABETEXT Study Protocol for a Randomised Clinical Trial. International journal of environmental research and public health [Internet]. Switzerland; 2022 Nov.;19(22):14706-. https://pubmed.ncbi.nlm.nih.gov/36429423

  AbstractURLBibTeXEndNoteDOIBibSonomyDownload

  BACKGROUND: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease associated with an increased risk of comorbidities, premature death, and health costs. Prediabetes is a stage of glucose alteration previous to T2DM, that can be reversed. The aim of the study is to develop and evaluate a low-intensity, multifaceted, digital intervention to prevent T2DM. The intervention comprises: (1) the use of mobile health technology to send tailored text messages promoting lifestyle changes to people at risk of T2DM and (2) the provision of online education to primary healthcare physicians and nurses about management of prediabetes. METHODS: In stages 1-4 we will design, develop and pilot-test the intervention. In Stage 5 we will conduct a phase II, six-month, three-arm, cluster randomized, clinical trial with 42 primary care professionals and 420 patients at risk of T2DM. Patients will be allocated to a control group (usual care), intervention A (patient messaging intervention), or intervention B (patient messaging intervention plus online education to their primary healthcare professionals). The primary outcome will be glycated haemoglobin. All the procedures obtained ethical approval in June 2021 (CEI-IB Ref No: IB4495/21PI). DISCUSSION: Digital health interventions can effectively prevent T2DM and reduce important T2DM risk factors such as overweight or hypertension. In Spain, this type of intervention is understudied. Moreover, there is controversy regarding the type of digital health interventions that are more effective. Findings from this study may contribute to address T2DM prevention, through a low-cost and easily implementable intervention.

  @article{galmespanades2022development,
  abstract = {BACKGROUND: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease associated with an increased risk of comorbidities, premature death, and health costs. Prediabetes is a stage of glucose alteration previous to T2DM, that can be reversed. The aim of the study is to develop and evaluate a low-intensity, multifaceted, digital intervention to prevent T2DM. The intervention comprises: (1) the use of mobile health technology to send tailored text messages promoting lifestyle changes to people at risk of T2DM and (2) the provision of online education to primary healthcare physicians and nurses about management of prediabetes. METHODS: In stages 1-4 we will design, develop and pilot-test the intervention. In Stage 5 we will conduct a phase II, six-month, three-arm, cluster randomized, clinical trial with 42 primary care professionals and 420 patients at risk of T2DM. Patients will be allocated to a control group (usual care), intervention A (patient messaging intervention), or intervention B (patient messaging intervention plus online education to their primary healthcare professionals). The primary outcome will be glycated haemoglobin. All the procedures obtained ethical approval in June 2021 (CEI-IB Ref No: IB4495/21PI). DISCUSSION: Digital health interventions can effectively prevent T2DM and reduce important T2DM risk factors such as overweight or hypertension. In Spain, this type of intervention is understudied. Moreover, there is controversy regarding the type of digital health interventions that are more effective. Findings from this study may contribute to address T2DM prevention, through a low-cost and easily implementable intervention.},
  address = {Switzerland},
  author = {Galmes-Panades, Aina M and Angullo, Escarlata and Mira-Martínez, Sofía and Bennasar-Veny, Miquel and Zamanillo-Campos, Rocío and Gómez-Juanes, Rocío and Konieczna, Jadwiga and Jiménez, Rafael and Serrano-Ripoll, Maria Jesús and Fiol deRoque, Maria Antonia and Miralles, Jerónima and Yañez, Aina M and Romaguera, Dora and Vidal-Thomas, Maria Clara and Llobera-Canaves, Joan and García-Toro, Mauro and Vicens, Catalina and Gervilla-García, Elena and Oña, José Iván and Malih, Narges and Leiva, Alfonso and Bulilete, Oana and Montaño, Juan José and Gili, Margalida and Roca, Miquel and Ricci-Cabello, Ignacio},
  journal = {International journal of environmental research and public health},
  keywords = {evisap},
  month = {nov},
  number = 22,
  pages = {14706--},
  title = {Development and Evaluation of a Digital Health Intervention to Prevent Type 2 Diabetes in Primary Care: The PREDIABETEXT Study Protocol for a Randomised Clinical Trial},
  volume = 19,
  year = 2022
  }
  

  %0 Journal Article
  %1 galmespanades2022development
  %A Galmes-Panades, Aina M
  %A Angullo, Escarlata
  %A Mira-Martínez, Sofía
  %A Bennasar-Veny, Miquel
  %A Zamanillo-Campos, Rocío
  %A Gómez-Juanes, Rocío
  %A Konieczna, Jadwiga
  %A Jiménez, Rafael
  %A Serrano-Ripoll, Maria Jesús
  %A Fiol deRoque, Maria Antonia
  %A Miralles, Jerónima
  %A Yañez, Aina M
  %A Romaguera, Dora
  %A Vidal-Thomas, Maria Clara
  %A Llobera-Canaves, Joan
  %A García-Toro, Mauro
  %A Vicens, Catalina
  %A Gervilla-García, Elena
  %A Oña, José Iván
  %A Malih, Narges
  %A Leiva, Alfonso
  %A Bulilete, Oana
  %A Montaño, Juan José
  %A Gili, Margalida
  %A Roca, Miquel
  %A Ricci-Cabello, Ignacio
  %C Switzerland
  %D 2022
  %J International journal of environmental research and public health
  %N 22
  %P 14706--
  %R 10.3390/ijerph192214706
  %T Development and Evaluation of a Digital Health Intervention to Prevent Type 2 Diabetes in Primary Care: The PREDIABETEXT Study Protocol for a Randomised Clinical Trial
  %U https://pubmed.ncbi.nlm.nih.gov/36429423
  %V 19
  %X BACKGROUND: Type 2 diabetes mellitus (T2DM) is a highly prevalent disease associated with an increased risk of comorbidities, premature death, and health costs. Prediabetes is a stage of glucose alteration previous to T2DM, that can be reversed. The aim of the study is to develop and evaluate a low-intensity, multifaceted, digital intervention to prevent T2DM. The intervention comprises: (1) the use of mobile health technology to send tailored text messages promoting lifestyle changes to people at risk of T2DM and (2) the provision of online education to primary healthcare physicians and nurses about management of prediabetes. METHODS: In stages 1-4 we will design, develop and pilot-test the intervention. In Stage 5 we will conduct a phase II, six-month, three-arm, cluster randomized, clinical trial with 42 primary care professionals and 420 patients at risk of T2DM. Patients will be allocated to a control group (usual care), intervention A (patient messaging intervention), or intervention B (patient messaging intervention plus online education to their primary healthcare professionals). The primary outcome will be glycated haemoglobin. All the procedures obtained ethical approval in June 2021 (CEI-IB Ref No: IB4495/21PI). DISCUSSION: Digital health interventions can effectively prevent T2DM and reduce important T2DM risk factors such as overweight or hypertension. In Spain, this type of intervention is understudied. Moreover, there is controversy regarding the type of digital health interventions that are more effective. Findings from this study may contribute to address T2DM prevention, through a low-cost and easily implementable intervention.
  

2021

• 
  1.

  Zamanillo Campos R, Rovira Boixadera L, Rendo Urteaga T. Common practices and beliefs in the preparation of complementary infant feeding in a Spanish sample: a cross-sectional study. Nutricion hospitalaria [Internet]. Spain; 2021 Oct.;38(5):919-34. https://pubmed.ncbi.nlm.nih.gov/34176276

  AbstractURLBibTeXEndNoteDOIBibSonomy

  Introduction: complementary feeding together with breast milk should cover the nutritional needs of children from 6 months onwards. Thus, inadequate dietary practices can lead to poor nutritional intake. The objective of this study was to examine infant food handling and cooking in Spanish households. Methodology: a cross-sectional study was carried out using an online survey in non-institutionalized adults living in Spain who usually prepare infant food for children under 2 years of age. Results: a total of 1,944 people (37.4 ± 6 years; 65.5 % women) answered the survey. Of these, 72 % prepared mainly mashed foods and 21 % used store-bought baby cereals frequently. Zucchini (39 %), chicken (62 %), hake (64 %) and banana (44 %) were the most commonly used foods. Boiling (63 %) and freezing (59 %) were the most widely used culinary and preservation practices. An inappropriate use of salt and some unsafe foods (large fish and chard) was identified, whereas olive oil and eggs were offered below the current nutritional recommendations. Conclusion: the population surveyed preferred to use mashed foods to feed children under 2 years of age. Even though they were aware that homemade food is nutritionally better, on certain occasions they offer store-bought baby cereal. Furthermore, some inappropriate feeding practices were detected, highlighting the need to implement nutritional education policies regarding infant food preparation.

  @article{zamanillocampos2021common,
  abstract = {Introduction: complementary feeding together with breast milk should cover the nutritional needs of children from 6 months onwards. Thus, inadequate dietary practices can lead to poor nutritional intake. The objective of this study was to examine infant food handling and cooking in Spanish households. Methodology: a cross-sectional study was carried out using an online survey in non-institutionalized adults living in Spain who usually prepare infant food for children under 2 years of age. Results: a total of 1,944 people (37.4 ± 6 years; 65.5 % women) answered the survey. Of these, 72 % prepared mainly mashed foods and 21 % used store-bought baby cereals frequently. Zucchini (39 %), chicken (62 %), hake (64 %) and banana (44 %) were the most commonly used foods. Boiling (63 %) and freezing (59 %) were the most widely used culinary and preservation practices. An inappropriate use of salt and some unsafe foods (large fish and chard) was identified, whereas olive oil and eggs were offered below the current nutritional recommendations. Conclusion: the population surveyed preferred to use mashed foods to feed children under 2 years of age. Even though they were aware that homemade food is nutritionally better, on certain occasions they offer store-bought baby cereal. Furthermore, some inappropriate feeding practices were detected, highlighting the need to implement nutritional education policies regarding infant food preparation.},
  address = {Spain},
  author = {Zamanillo Campos, Rocío and Rovira Boixadera, Laia and Rendo Urteaga, Tara},
  journal = {Nutricion hospitalaria},
  keywords = {evisap},
  month = {oct},
  number = 5,
  pages = {919--934},
  title = {Common practices and beliefs in the preparation of complementary infant feeding in a Spanish sample: a cross-sectional study},
  volume = 38,
  year = 2021
  }
  

  %0 Journal Article
  %1 zamanillocampos2021common
  %A Zamanillo Campos, Rocío
  %A Rovira Boixadera, Laia
  %A Rendo Urteaga, Tara
  %C Spain
  %D 2021
  %J Nutricion hospitalaria
  %N 5
  %P 919--934
  %R 10.20960/nh.03527
  %T Common practices and beliefs in the preparation of complementary infant feeding in a Spanish sample: a cross-sectional study
  %U https://pubmed.ncbi.nlm.nih.gov/34176276
  %V 38
  %X Introduction: complementary feeding together with breast milk should cover the nutritional needs of children from 6 months onwards. Thus, inadequate dietary practices can lead to poor nutritional intake. The objective of this study was to examine infant food handling and cooking in Spanish households. Methodology: a cross-sectional study was carried out using an online survey in non-institutionalized adults living in Spain who usually prepare infant food for children under 2 years of age. Results: a total of 1,944 people (37.4 ± 6 years; 65.5 % women) answered the survey. Of these, 72 % prepared mainly mashed foods and 21 % used store-bought baby cereals frequently. Zucchini (39 %), chicken (62 %), hake (64 %) and banana (44 %) were the most commonly used foods. Boiling (63 %) and freezing (59 %) were the most widely used culinary and preservation practices. An inappropriate use of salt and some unsafe foods (large fish and chard) was identified, whereas olive oil and eggs were offered below the current nutritional recommendations. Conclusion: the population surveyed preferred to use mashed foods to feed children under 2 years of age. Even though they were aware that homemade food is nutritionally better, on certain occasions they offer store-bought baby cereal. Furthermore, some inappropriate feeding practices were detected, highlighting the need to implement nutritional education policies regarding infant food preparation.
  

• 
  1.

  Thulesius H, Sandén U, Petek D, Hoffman R, Koskela T, Oliva-Fanlo B, Neves AL, Hajdarevic S, Harrysson L, Toftegaard BS, Vedsted P, Harris M. Pluralistic task shifting for a more timely cancer diagnosis. A grounded theory study from a primary care perspective. Scand J Prim Health Care. 2021;39(4):486-97.

  AbstractBibTeXEndNoteDOIBibSonomyDownload

  OBJECTIVE: To explore how cancer could be diagnosed in a more timely way. DESIGN: Grounded theory analysis of primary care physicians' free text survey responses to: 'How do you think the speed of diagnosis of cancer in primary care could be improved?'. Secondary analysis of primary care physician interviews, survey responses, literature. SETTING: Primary care in 20 European Örenäs Research Group countries. SUBJECTS: Primary care physicians: 1352 survey respondents (2013-2016), 20 Spanish and 7 Swedish interviewees (2015-2019). MAIN OUTCOME MEASURES: Conceptual explanation of how to improve timeliness of cancer diagnosis. RESULTS: Pluralistic task shifting is a grounded theory of a composite strategy. It includes task sharing - among nurses, physicians, nurse assistants, secretaries, and patients - and changing tasks with cancer screening when appropriate or cancer fast-tracks to accelerate cancer case finding. A pluralistic dialogue culture of comprehensive collaboration and task redistribution is required for effective pluralistic task shifting. Pluralistic task shifting relies on cognitive task shifting, which includes learning more about slow analytic reasoning and fast automatic thinking initiated by pattern recognition; and digital task shifting, which by use of eHealth and telemedicine bridges time and place and improves power symmetry between patients, caregivers, and clinicians. Financial task shifting that involves cost tracking followed by reallocation of funds is necessary for the restructuring and retraining required for successful pluralistic task shifting. A timely diagnosis reduces expensive investigations and waiting times. Also, late-stage cancers are costlier to treat than early-stage cancers. Timing is central to cancer diagnosis: not too early to avoid overdiagnosis, and never too late. CONCLUSIONS: We present pluralistic task shifting as a conceptual summary of strategies needed to optimise the timeliness of cancer diagnosis.Key pointsCancer diagnosis is under-researched in primary care, especially theoretically. Thus, inspired by classic grounded theory, we analysed and conceptualised the field:Pluralistic task shifting is a conceptual explanation of how the timeliness of cancer diagnosis could be improved, with data derived mostly from primary care physicians.This includes task sharing and changing tasks including screening and cancer fast-tracks to accelerate cancer case finding, and requires cognitive task shifting emphasising learning, and digital task shifting involving the use of eHealth and telemedicine.Financial task shifting with cost tracking and reallocation of funds is eventually necessary for successful pluralistic task shifting to happen.

  @article{RN75,
  abstract = {OBJECTIVE: To explore how cancer could be diagnosed in a more timely way. DESIGN: Grounded theory analysis of primary care physicians' free text survey responses to: 'How do you think the speed of diagnosis of cancer in primary care could be improved?'. Secondary analysis of primary care physician interviews, survey responses, literature. SETTING: Primary care in 20 European Örenäs Research Group countries. SUBJECTS: Primary care physicians: 1352 survey respondents (2013-2016), 20 Spanish and 7 Swedish interviewees (2015-2019). MAIN OUTCOME MEASURES: Conceptual explanation of how to improve timeliness of cancer diagnosis. RESULTS: Pluralistic task shifting is a grounded theory of a composite strategy. It includes task sharing - among nurses, physicians, nurse assistants, secretaries, and patients - and changing tasks with cancer screening when appropriate or cancer fast-tracks to accelerate cancer case finding. A pluralistic dialogue culture of comprehensive collaboration and task redistribution is required for effective pluralistic task shifting. Pluralistic task shifting relies on cognitive task shifting, which includes learning more about slow analytic reasoning and fast automatic thinking initiated by pattern recognition; and digital task shifting, which by use of eHealth and telemedicine bridges time and place and improves power symmetry between patients, caregivers, and clinicians. Financial task shifting that involves cost tracking followed by reallocation of funds is necessary for the restructuring and retraining required for successful pluralistic task shifting. A timely diagnosis reduces expensive investigations and waiting times. Also, late-stage cancers are costlier to treat than early-stage cancers. Timing is central to cancer diagnosis: not too early to avoid overdiagnosis, and never too late. CONCLUSIONS: We present pluralistic task shifting as a conceptual summary of strategies needed to optimise the timeliness of cancer diagnosis.Key pointsCancer diagnosis is under-researched in primary care, especially theoretically. Thus, inspired by classic grounded theory, we analysed and conceptualised the field:Pluralistic task shifting is a conceptual explanation of how the timeliness of cancer diagnosis could be improved, with data derived mostly from primary care physicians.This includes task sharing and changing tasks including screening and cancer fast-tracks to accelerate cancer case finding, and requires cognitive task shifting emphasising learning, and digital task shifting involving the use of eHealth and telemedicine.Financial task shifting with cost tracking and reallocation of funds is eventually necessary for successful pluralistic task shifting to happen.},
  author = {Thulesius, H. and Sandén, U. and Petek, D. and Hoffman, R. and Koskela, T. and Oliva-Fanlo, B. and Neves, A. L. and Hajdarevic, S. and Harrysson, L. and Toftegaard, B. S. and Vedsted, P. and Harris, M.},
  journal = {Scand J Prim Health Care},
  keywords = {grapp-caib},
  number = 4,
  pages = {486-497},
  title = {Pluralistic task shifting for a more timely cancer diagnosis. A grounded theory study from a primary care perspective},
  type = {Journal Article},
  volume = 39,
  year = 2021
  }
  

  %0 Journal Article
  %1 RN75
  %A Thulesius, H.
  %A Sandén, U.
  %A Petek, D.
  %A Hoffman, R.
  %A Koskela, T.
  %A Oliva-Fanlo, B.
  %A Neves, A. L.
  %A Hajdarevic, S.
  %A Harrysson, L.
  %A Toftegaard, B. S.
  %A Vedsted, P.
  %A Harris, M.
  %D 2021
  %J Scand J Prim Health Care
  %N 4
  %P 486-497
  %R 10.1080/02813432.2021.2004751
  %T Pluralistic task shifting for a more timely cancer diagnosis. A grounded theory study from a primary care perspective
  %V 39
  %X OBJECTIVE: To explore how cancer could be diagnosed in a more timely way. DESIGN: Grounded theory analysis of primary care physicians' free text survey responses to: 'How do you think the speed of diagnosis of cancer in primary care could be improved?'. Secondary analysis of primary care physician interviews, survey responses, literature. SETTING: Primary care in 20 European Örenäs Research Group countries. SUBJECTS: Primary care physicians: 1352 survey respondents (2013-2016), 20 Spanish and 7 Swedish interviewees (2015-2019). MAIN OUTCOME MEASURES: Conceptual explanation of how to improve timeliness of cancer diagnosis. RESULTS: Pluralistic task shifting is a grounded theory of a composite strategy. It includes task sharing - among nurses, physicians, nurse assistants, secretaries, and patients - and changing tasks with cancer screening when appropriate or cancer fast-tracks to accelerate cancer case finding. A pluralistic dialogue culture of comprehensive collaboration and task redistribution is required for effective pluralistic task shifting. Pluralistic task shifting relies on cognitive task shifting, which includes learning more about slow analytic reasoning and fast automatic thinking initiated by pattern recognition; and digital task shifting, which by use of eHealth and telemedicine bridges time and place and improves power symmetry between patients, caregivers, and clinicians. Financial task shifting that involves cost tracking followed by reallocation of funds is necessary for the restructuring and retraining required for successful pluralistic task shifting. A timely diagnosis reduces expensive investigations and waiting times. Also, late-stage cancers are costlier to treat than early-stage cancers. Timing is central to cancer diagnosis: not too early to avoid overdiagnosis, and never too late. CONCLUSIONS: We present pluralistic task shifting as a conceptual summary of strategies needed to optimise the timeliness of cancer diagnosis.Key pointsCancer diagnosis is under-researched in primary care, especially theoretically. Thus, inspired by classic grounded theory, we analysed and conceptualised the field:Pluralistic task shifting is a conceptual explanation of how the timeliness of cancer diagnosis could be improved, with data derived mostly from primary care physicians.This includes task sharing and changing tasks including screening and cancer fast-tracks to accelerate cancer case finding, and requires cognitive task shifting emphasising learning, and digital task shifting involving the use of eHealth and telemedicine.Financial task shifting with cost tracking and reallocation of funds is eventually necessary for successful pluralistic task shifting to happen.
  

• 
  1.

  Gangannagaripalli J, Porter I, Davey A, Ricci Cabello I, Greenhalgh J, Anderson R, Briscoe S, Hughes C, Payne R, Cockcroft E, Harris J, Bramwell C, Valderas JM. STOPP/START interventions to improve medicines management for people aged 65 years and over: a realist synthesis [Internet]. Southampton (UK): NIHR Journals Library; 2021. https://pubmed.ncbi.nlm.nih.gov/34846830

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUND: Drug-related problems and potentially inappropriate prescribing impose a huge burden on patients and the health-care system. The most widely used tools for appropriate prescription in older adults in England and in other European countries are the Screening Tool of Older People’s Prescriptions (STOPP)/Screening Tool to Alert to the Right Treatment (START) tools. STOPP/START tools support medicines optimisation for older adults. OBJECTIVES: To identify, test and refine the programme theories underlying how interventions based on the STOPP/START tools are intended to work, for whom, in what circumstances and why, as well as the resource use and cost requirements or impacts. DESIGN: A realist synthesis. SETTING: Primary care, hospital care and nursing homes. PATIENTS: Patients aged ≥ 65 years. INTERVENTIONS: Any intervention based on the use of the STOPP/START tools. REVIEW METHODS: Database and web-searching was carried out to retrieve relevant evidence to identify and test programme theories about how interventions based on the use of the STOPP/START tools work. A project reference group made up of health-care professionals, NHS decision-makers, older people, carers and members of the public was set up. In phase 1 we identified programme theories about STOPP/START interventions on how, for whom, in what contexts and why they are intended to work. We searched the peer-reviewed and grey literature to identify documents relevant to the research questions. We interviewed experts in the field in our reference group to gain input on our list of candidate context–mechanism–outcome configurations, to identify additional context–mechanism–outcome configurations and to identify additional literature and/or relevant concepts. In phase 2 we reviewed and synthesised relevant published and unpublished empirical evidence and tested the programme theories using evidence from a larger set of empirical studies. RESULTS: We developed a single logic model structured around three key mechanisms: (1) personalisation, (2) systematisation and (3) evidence implementation. Personalisation: STOPP/START-based interventions are based on shared decision-making, taking into account patient preferences, experiences and expectations (mechanisms), leading to increased patient awareness, adherence, satisfaction, empowerment and quality of life (outcomes). Systematisation: STOPP/START tools provide a standardised/systematic approach for medication reviews (mechanisms), leading to changes in professional and organisational culture and burden/costs (outcomes). Evidence implementation: delivery of STOPP/START-based interventions is based on the implementation of best evidence (mechanisms), reducing adverse outcomes through appropriate prescribing/deprescribing (outcomes). For theory testing, we identified 40 studies of the impact of STOPP/START-based interventions in hospital settings, nursing homes, primary care and community pharmacies. Most of the interventions used multiple mechanisms. We found support for the impact of the personalisation and evidence implementation mechanisms on selected outcome variables, but similar impact was achieved by interventions not relying on these mechanisms. We also observed that the impact of interventions was linked to the proximity of the selected outcomes to the intervention in the logic model, resulting in a clearer benefit for appropriateness of prescribing, adverse drug events and prescription costs. LIMITATIONS: None of the available studies had been explicitly designed for evaluating underlying causal mechanisms, and qualitative information was sparse. CONCLUSIONS: No particular configuration of the interventions is associated with a greater likelihood of improved outcomes in given settings. STUDY REGISTRATION: This study is registered as PROSPERO CRD42018110795. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Services and Delivery Research programme and will be published in full in Health Services and Delivery Research; Vol. 9, No. 23. See the NIHR Journals Library website for further project information.

  @book{gangannagaripalli2021stoppstart,
  abstract = {BACKGROUND: Drug-related problems and potentially inappropriate prescribing impose a huge burden on patients and the health-care system. The most widely used tools for appropriate prescription in older adults in England and in other European countries are the Screening Tool of Older People’s Prescriptions (STOPP)/Screening Tool to Alert to the Right Treatment (START) tools. STOPP/START tools support medicines optimisation for older adults. OBJECTIVES: To identify, test and refine the programme theories underlying how interventions based on the STOPP/START tools are intended to work, for whom, in what circumstances and why, as well as the resource use and cost requirements or impacts. DESIGN: A realist synthesis. SETTING: Primary care, hospital care and nursing homes. PATIENTS: Patients aged ≥ 65 years. INTERVENTIONS: Any intervention based on the use of the STOPP/START tools. REVIEW METHODS: Database and web-searching was carried out to retrieve relevant evidence to identify and test programme theories about how interventions based on the use of the STOPP/START tools work. A project reference group made up of health-care professionals, NHS decision-makers, older people, carers and members of the public was set up. In phase 1 we identified programme theories about STOPP/START interventions on how, for whom, in what contexts and why they are intended to work. We searched the peer-reviewed and grey literature to identify documents relevant to the research questions. We interviewed experts in the field in our reference group to gain input on our list of candidate context–mechanism–outcome configurations, to identify additional context–mechanism–outcome configurations and to identify additional literature and/or relevant concepts. In phase 2 we reviewed and synthesised relevant published and unpublished empirical evidence and tested the programme theories using evidence from a larger set of empirical studies. RESULTS: We developed a single logic model structured around three key mechanisms: (1) personalisation, (2) systematisation and (3) evidence implementation. Personalisation: STOPP/START-based interventions are based on shared decision-making, taking into account patient preferences, experiences and expectations (mechanisms), leading to increased patient awareness, adherence, satisfaction, empowerment and quality of life (outcomes). Systematisation: STOPP/START tools provide a standardised/systematic approach for medication reviews (mechanisms), leading to changes in professional and organisational culture and burden/costs (outcomes). Evidence implementation: delivery of STOPP/START-based interventions is based on the implementation of best evidence (mechanisms), reducing adverse outcomes through appropriate prescribing/deprescribing (outcomes). For theory testing, we identified 40 studies of the impact of STOPP/START-based interventions in hospital settings, nursing homes, primary care and community pharmacies. Most of the interventions used multiple mechanisms. We found support for the impact of the personalisation and evidence implementation mechanisms on selected outcome variables, but similar impact was achieved by interventions not relying on these mechanisms. We also observed that the impact of interventions was linked to the proximity of the selected outcomes to the intervention in the logic model, resulting in a clearer benefit for appropriateness of prescribing, adverse drug events and prescription costs. LIMITATIONS: None of the available studies had been explicitly designed for evaluating underlying causal mechanisms, and qualitative information was sparse. CONCLUSIONS: No particular configuration of the interventions is associated with a greater likelihood of improved outcomes in given settings. STUDY REGISTRATION: This study is registered as PROSPERO CRD42018110795. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Services and Delivery Research programme and will be published in full in Health Services and Delivery Research; Vol. 9, No. 23. See the NIHR Journals Library website for further project information.},
  address = {Southampton (UK)},
  author = {Gangannagaripalli, Jaheeda and Porter, Ian and Davey, Antoinette and Ricci Cabello, Ignacio and Greenhalgh, Joanne and Anderson, Rob and Briscoe, Simon and Hughes, Carmel and Payne, Rupert and Cockcroft, Emma and Harris, Jim and Bramwell, Charlotte and Valderas, Jose M},
  keywords = {evisap},
  month = {nov},
  publisher = {NIHR Journals Library},
  title = {STOPP/START interventions to improve medicines management for people aged 65 years and over: a realist synthesis},
  year = 2021
  }
  

  %0 Book
  %1 gangannagaripalli2021stoppstart
  %A Gangannagaripalli, Jaheeda
  %A Porter, Ian
  %A Davey, Antoinette
  %A Ricci Cabello, Ignacio
  %A Greenhalgh, Joanne
  %A Anderson, Rob
  %A Briscoe, Simon
  %A Hughes, Carmel
  %A Payne, Rupert
  %A Cockcroft, Emma
  %A Harris, Jim
  %A Bramwell, Charlotte
  %A Valderas, Jose M
  %C Southampton (UK)
  %D 2021
  %I NIHR Journals Library
  %R 10.3310/hsdr09230
  %T STOPP/START interventions to improve medicines management for people aged 65 years and over: a realist synthesis
  %U https://pubmed.ncbi.nlm.nih.gov/34846830
  %X BACKGROUND: Drug-related problems and potentially inappropriate prescribing impose a huge burden on patients and the health-care system. The most widely used tools for appropriate prescription in older adults in England and in other European countries are the Screening Tool of Older People’s Prescriptions (STOPP)/Screening Tool to Alert to the Right Treatment (START) tools. STOPP/START tools support medicines optimisation for older adults. OBJECTIVES: To identify, test and refine the programme theories underlying how interventions based on the STOPP/START tools are intended to work, for whom, in what circumstances and why, as well as the resource use and cost requirements or impacts. DESIGN: A realist synthesis. SETTING: Primary care, hospital care and nursing homes. PATIENTS: Patients aged ≥ 65 years. INTERVENTIONS: Any intervention based on the use of the STOPP/START tools. REVIEW METHODS: Database and web-searching was carried out to retrieve relevant evidence to identify and test programme theories about how interventions based on the use of the STOPP/START tools work. A project reference group made up of health-care professionals, NHS decision-makers, older people, carers and members of the public was set up. In phase 1 we identified programme theories about STOPP/START interventions on how, for whom, in what contexts and why they are intended to work. We searched the peer-reviewed and grey literature to identify documents relevant to the research questions. We interviewed experts in the field in our reference group to gain input on our list of candidate context–mechanism–outcome configurations, to identify additional context–mechanism–outcome configurations and to identify additional literature and/or relevant concepts. In phase 2 we reviewed and synthesised relevant published and unpublished empirical evidence and tested the programme theories using evidence from a larger set of empirical studies. RESULTS: We developed a single logic model structured around three key mechanisms: (1) personalisation, (2) systematisation and (3) evidence implementation. Personalisation: STOPP/START-based interventions are based on shared decision-making, taking into account patient preferences, experiences and expectations (mechanisms), leading to increased patient awareness, adherence, satisfaction, empowerment and quality of life (outcomes). Systematisation: STOPP/START tools provide a standardised/systematic approach for medication reviews (mechanisms), leading to changes in professional and organisational culture and burden/costs (outcomes). Evidence implementation: delivery of STOPP/START-based interventions is based on the implementation of best evidence (mechanisms), reducing adverse outcomes through appropriate prescribing/deprescribing (outcomes). For theory testing, we identified 40 studies of the impact of STOPP/START-based interventions in hospital settings, nursing homes, primary care and community pharmacies. Most of the interventions used multiple mechanisms. We found support for the impact of the personalisation and evidence implementation mechanisms on selected outcome variables, but similar impact was achieved by interventions not relying on these mechanisms. We also observed that the impact of interventions was linked to the proximity of the selected outcomes to the intervention in the logic model, resulting in a clearer benefit for appropriateness of prescribing, adverse drug events and prescription costs. LIMITATIONS: None of the available studies had been explicitly designed for evaluating underlying causal mechanisms, and qualitative information was sparse. CONCLUSIONS: No particular configuration of the interventions is associated with a greater likelihood of improved outcomes in given settings. STUDY REGISTRATION: This study is registered as PROSPERO CRD42018110795. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Services and Delivery Research programme and will be published in full in Health Services and Delivery Research; Vol. 9, No. 23. See the NIHR Journals Library website for further project information.
  

• 
  1.

  Zamanillo Campos R, Colomar Ferrer MT, Ruiz López RM, Sanchís Cortés MP, Urgelés Planella JR. Specific Quality of Life Assessment by the NutriQoL® Questionnaire Among Patients Receiving Home Enteral Nutrition. JPEN. Journal of parenteral and enteral nutrition [Internet]. United States; 2021 Mar.;45(3):490-8. https://pubmed.ncbi.nlm.nih.gov/32459026

  AbstractURLBibTeXEndNoteDOIBibSonomy

  BACKGROUND: Home enteral nutrition (HEN), including tube feeding and oral supplementation, can improve or worsen quality of life (QoL). The specific assessment of factors affecting QoL may identify the inherent problems associated with HEN. The aim of this study was to evaluate whether the validated NutriQoL® questionnaire is useful for assessing the QoL and the factors influencing it in patients receiving HEN. METHODS: A total of 78 patients receiving HEN completed both the NutriQoL and the SF-12 questionnaires during their routine visits to nutrition service at the hospital. RESULTS: Ninety percent of patients receiving HEN had cancer, 58% received oral supplements, and 42% received tube feeding. At recruitment, the mean score ± SD of the NutriQoL was 66 ± 14, whereas that of the SF-12 was 40 ± 9. A positive correlation between NutriQoL and SF-12 scores (ρ = 0.5; P < .001) was found. Multivariate analysis showed that HEN type (oral vs tube) (odds ratio [OR], 5.6; 95% CI 2.0-15.3; P = .001) and the absence of secondary effects (OR, 3.0; 95% CI, 1.2-7.9; P = .024) were both variables explaining NutriQoL results adjusted by sex and age. The SF-12 results did not show associations with nutrition factors. On visit 2, we observed significant improvements in NutriQoL results. CONCLUSION: The NutriQoL questionnaire identifies specific problems that affect the QoL of patients receiving HEN, whereas SF-12 does not. The route of entry and the occurrence of complications influence specific QoL. NutriQoL is a useful tool to identify the factors that worsen the QoL in patients receiving HEN.

  @article{zamanillocampos2021specific,
  abstract = {BACKGROUND: Home enteral nutrition (HEN), including tube feeding and oral supplementation, can improve or worsen quality of life (QoL). The specific assessment of factors affecting QoL may identify the inherent problems associated with HEN. The aim of this study was to evaluate whether the validated NutriQoL® questionnaire is useful for assessing the QoL and the factors influencing it in patients receiving HEN. METHODS: A total of 78 patients receiving HEN completed both the NutriQoL and the SF-12 questionnaires during their routine visits to nutrition service at the hospital. RESULTS: Ninety percent of patients receiving HEN had cancer, 58% received oral supplements, and 42% received tube feeding. At recruitment, the mean score ± SD of the NutriQoL was 66 ± 14, whereas that of the SF-12 was 40 ± 9. A positive correlation between NutriQoL and SF-12 scores (ρ = 0.5; P < .001) was found. Multivariate analysis showed that HEN type (oral vs tube) (odds ratio [OR], 5.6; 95% CI 2.0-15.3; P = .001) and the absence of secondary effects (OR, 3.0; 95% CI, 1.2-7.9; P = .024) were both variables explaining NutriQoL results adjusted by sex and age. The SF-12 results did not show associations with nutrition factors. On visit 2, we observed significant improvements in NutriQoL results. CONCLUSION: The NutriQoL questionnaire identifies specific problems that affect the QoL of patients receiving HEN, whereas SF-12 does not. The route of entry and the occurrence of complications influence specific QoL. NutriQoL is a useful tool to identify the factors that worsen the QoL in patients receiving HEN.},
  address = {United States},
  author = {Zamanillo Campos, Rocío and Colomar Ferrer, María Teresa and Ruiz López, Rosa María and Sanchís Cortés, María Pilar and Urgelés Planella, Joan Ramón},
  journal = {JPEN. Journal of parenteral and enteral nutrition},
  keywords = {evisap},
  month = {mar},
  number = 3,
  pages = {490--498},
  title = {Specific Quality of Life Assessment by the NutriQoL® Questionnaire Among Patients Receiving Home Enteral Nutrition},
  volume = 45,
  year = 2021
  }
  

  %0 Journal Article
  %1 zamanillocampos2021specific
  %A Zamanillo Campos, Rocío
  %A Colomar Ferrer, María Teresa
  %A Ruiz López, Rosa María
  %A Sanchís Cortés, María Pilar
  %A Urgelés Planella, Joan Ramón
  %C United States
  %D 2021
  %J JPEN. Journal of parenteral and enteral nutrition
  %N 3
  %P 490--498
  %R 10.1002/jpen.1852
  %T Specific Quality of Life Assessment by the NutriQoL® Questionnaire Among Patients Receiving Home Enteral Nutrition
  %U https://pubmed.ncbi.nlm.nih.gov/32459026
  %V 45
  %X BACKGROUND: Home enteral nutrition (HEN), including tube feeding and oral supplementation, can improve or worsen quality of life (QoL). The specific assessment of factors affecting QoL may identify the inherent problems associated with HEN. The aim of this study was to evaluate whether the validated NutriQoL® questionnaire is useful for assessing the QoL and the factors influencing it in patients receiving HEN. METHODS: A total of 78 patients receiving HEN completed both the NutriQoL and the SF-12 questionnaires during their routine visits to nutrition service at the hospital. RESULTS: Ninety percent of patients receiving HEN had cancer, 58% received oral supplements, and 42% received tube feeding. At recruitment, the mean score ± SD of the NutriQoL was 66 ± 14, whereas that of the SF-12 was 40 ± 9. A positive correlation between NutriQoL and SF-12 scores (ρ = 0.5; P < .001) was found. Multivariate analysis showed that HEN type (oral vs tube) (odds ratio [OR], 5.6; 95% CI 2.0-15.3; P = .001) and the absence of secondary effects (OR, 3.0; 95% CI, 1.2-7.9; P = .024) were both variables explaining NutriQoL results adjusted by sex and age. The SF-12 results did not show associations with nutrition factors. On visit 2, we observed significant improvements in NutriQoL results. CONCLUSION: The NutriQoL questionnaire identifies specific problems that affect the QoL of patients receiving HEN, whereas SF-12 does not. The route of entry and the occurrence of complications influence specific QoL. NutriQoL is a useful tool to identify the factors that worsen the QoL in patients receiving HEN.
  

2020

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  1.

  Schünemann HJ, Lerda D, Quinn C, Follmann M, Alonso-Coello P, Rossi PG, Lebeau A, Nyström L, Broeders M, Ioannidou-Mouzaka L, Duffy SW, Borisch B, Fitzpatrick P, Hofvind S, Castells X, Giordano L, Canelo-Aybar C, Warman S, Mansel R, Sardanelli F, Parmelli E, Gräwingholt A, Saz-Parkinson Z, on Breast Cancer (ECIBC) Contributor Group ECI. Breast Cancer Screening and Diagnosis: A Synopsis of the European Breast Guidelines. Annals of internal medicine [Internet]. United States; 2020 Jan.;172(1):46-5. https://pubmed.ncbi.nlm.nih.gov/31766052

  AbstractURLBibTeXEndNoteDOIBibSonomy

  DESCRIPTION: The European Commission Initiative for Breast Cancer Screening and Diagnosis guidelines (European Breast Guidelines) are coordinated by the European Commission's Joint Research Centre. The target audience for the guidelines includes women, health professionals, and policymakers. METHODS: An international guideline panel of 28 multidisciplinary members, including patients, developed questions and corresponding recommendations that were informed by systematic reviews of the evidence conducted between March 2016 and December 2018. GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision frameworks were used to structure the process and minimize the influence of competing interests by enhancing transparency. Questions and recommendations, expressed as strong or conditional, focused on outcomes that matter to women and provided a rating of the certainty of evidence. RECOMMENDATIONS: This synopsis of the European Breast Guidelines provides recommendations regarding organized screening programs for women aged 40 to 75 years who are at average risk. The recommendations address digital mammography screening and the addition of hand-held ultrasonography, automated breast ultrasonography, or magnetic resonance imaging compared with mammography alone. The recommendations also discuss the frequency of screening and inform decision making for women at average risk who are recalled for suspicious lesions or who have high breast density.

  @article{schunemann2020breast,
  abstract = {DESCRIPTION: The European Commission Initiative for Breast Cancer Screening and Diagnosis guidelines (European Breast Guidelines) are coordinated by the European Commission's Joint Research Centre. The target audience for the guidelines includes women, health professionals, and policymakers. METHODS: An international guideline panel of 28 multidisciplinary members, including patients, developed questions and corresponding recommendations that were informed by systematic reviews of the evidence conducted between March 2016 and December 2018. GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision frameworks were used to structure the process and minimize the influence of competing interests by enhancing transparency. Questions and recommendations, expressed as strong or conditional, focused on outcomes that matter to women and provided a rating of the certainty of evidence. RECOMMENDATIONS: This synopsis of the European Breast Guidelines provides recommendations regarding organized screening programs for women aged 40 to 75 years who are at average risk. The recommendations address digital mammography screening and the addition of hand-held ultrasonography, automated breast ultrasonography, or magnetic resonance imaging compared with mammography alone. The recommendations also discuss the frequency of screening and inform decision making for women at average risk who are recalled for suspicious lesions or who have high breast density.},
  address = {United States},
  author = {Schünemann, Holger J and Lerda, Donata and Quinn, Cecily and Follmann, Markus and Alonso-Coello, Pablo and Rossi, Paolo Giorgi and Lebeau, Annette and Nyström, Lennarth and Broeders, Mireille and Ioannidou-Mouzaka, Lydia and Duffy, Stephen W and Borisch, Bettina and Fitzpatrick, Patricia and Hofvind, Solveig and Castells, Xavier and Giordano, Livia and Canelo-Aybar, Carlos and Warman, Sue and Mansel, Robert and Sardanelli, Francesco and Parmelli, Elena and Gräwingholt, Axel and Saz-Parkinson, Zuleika and on Breast Cancer (ECIBC) Contributor Group, European Commission Initiative},
  journal = {Annals of internal medicine},
  keywords = {evisap},
  month = {jan},
  number = 1,
  pages = {46--56},
  title = {Breast Cancer Screening and Diagnosis: A Synopsis of the European Breast Guidelines},
  volume = 172,
  year = 2020
  }
  

  %0 Journal Article
  %1 schunemann2020breast
  %A Schünemann, Holger J
  %A Lerda, Donata
  %A Quinn, Cecily
  %A Follmann, Markus
  %A Alonso-Coello, Pablo
  %A Rossi, Paolo Giorgi
  %A Lebeau, Annette
  %A Nyström, Lennarth
  %A Broeders, Mireille
  %A Ioannidou-Mouzaka, Lydia
  %A Duffy, Stephen W
  %A Borisch, Bettina
  %A Fitzpatrick, Patricia
  %A Hofvind, Solveig
  %A Castells, Xavier
  %A Giordano, Livia
  %A Canelo-Aybar, Carlos
  %A Warman, Sue
  %A Mansel, Robert
  %A Sardanelli, Francesco
  %A Parmelli, Elena
  %A Gräwingholt, Axel
  %A Saz-Parkinson, Zuleika
  %A on Breast Cancer (ECIBC) Contributor Group, European Commission Initiative
  %C United States
  %D 2020
  %J Annals of internal medicine
  %N 1
  %P 46--56
  %R 10.7326/M19-2125
  %T Breast Cancer Screening and Diagnosis: A Synopsis of the European Breast Guidelines
  %U https://pubmed.ncbi.nlm.nih.gov/31766052
  %V 172
  %X DESCRIPTION: The European Commission Initiative for Breast Cancer Screening and Diagnosis guidelines (European Breast Guidelines) are coordinated by the European Commission's Joint Research Centre. The target audience for the guidelines includes women, health professionals, and policymakers. METHODS: An international guideline panel of 28 multidisciplinary members, including patients, developed questions and corresponding recommendations that were informed by systematic reviews of the evidence conducted between March 2016 and December 2018. GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision frameworks were used to structure the process and minimize the influence of competing interests by enhancing transparency. Questions and recommendations, expressed as strong or conditional, focused on outcomes that matter to women and provided a rating of the certainty of evidence. RECOMMENDATIONS: This synopsis of the European Breast Guidelines provides recommendations regarding organized screening programs for women aged 40 to 75 years who are at average risk. The recommendations address digital mammography screening and the addition of hand-held ultrasonography, automated breast ultrasonography, or magnetic resonance imaging compared with mammography alone. The recommendations also discuss the frequency of screening and inform decision making for women at average risk who are recalled for suspicious lesions or who have high breast density.